Antimony Patents (Class 424/651)
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Patent number: 10766922Abstract: A compound and pharmaceutically acceptable salts thereof for treating cancer, having a structure represented by the following formula (I) or formula (II): in which X and Y each individually represent: R1, R2, R3, R4, and R5 individually represents hydrogen atom, acyl having 20 or less carbon atoms, alkyl having 20 or less carbon atoms, alkanoyl having 20 or less carbon atoms, aroyl having 20 or less carbon atoms, aryl having 20 or less carbon atoms, aralkyl having 20 or less carbon atoms, sulfonyl having 20 or less carbon atoms, phosphonyl having 20 or less carbon atoms, or haloacyl having 20 or less carbon atoms.Type: GrantFiled: May 28, 2019Date of Patent: September 8, 2020Assignee: AQUAVAN TECHNOLOGY CO., LTD.Inventors: Kuo-Tang Tseng, Hsin Ju Wang, Wen-Hung Chen
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Patent number: 9585894Abstract: In addition to its potent mechanism-dependent inhibition of estrogen biosynthesis, in accordance with the embodiments of the present invention, it has now been found that exemestane has novel chemoprotective properties which have hitherto not been explicitly recognized. The present invention provides methods for the use of compositions comprising exemestane for chemoprotection against a wide variety of non-mammary tumors (and possibly other chronic diseases) that are not estrogen-dependent, but have oxidative stress, inflammation and electrophile-damaging etiologies. The present invention also shows that exemestane shows powerful synergism with other classes of Nrf2-activators and phase 2 enzyme gene activators, including, for example sulforaphane (an isothiocyanate), shikonin (a naphthoquinone), zerumbone (a cyclic sesquiterpene) and resveratrol (a stilbene derivative), which increases the attractiveness of exemestane's novel uses.Type: GrantFiled: July 17, 2014Date of Patent: March 7, 2017Assignee: The Johns Hopkins UniversityInventors: Paul Talalay, Hua Liu
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Patent number: 9028878Abstract: Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural surfaces that contain bacterial biofilm, including unexpected synergy or enhancing effects between bismuth-thiol (BT) compounds and certain antibiotics, to provide formulations including antiseptic formulations. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating certain gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating certain gram-negative bacterial infections.Type: GrantFiled: August 3, 2012Date of Patent: May 12, 2015Assignee: Microbion CorporationInventor: Brett Hugh James Baker
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Publication number: 20140271923Abstract: Patients inflicted with various clustering chronic diseases require treatment with multiple drugs having distinct mechanisms of action. Accordingly, patients with multiple conditions suffer from cumulative side effects of multiple drugs as well as drug-drug interactions. Embodiments, agents, compounds or drugs of the present invention, such as sesquiterpenes, e.g., Zerumbone, replace an equal or larger number of approved drugs during patient treatment. Examples of disorders prevented or ameliorated by administration of the formulations of this invention include but are not limited to inflammatory diseases that may be, oncological, genetic, ischemic, infectious, neurological, hematological, ophthalmological, rheumatoid, orthopedic, neurological, hematological, kidney, vascular, dermatological, gynecological, or obstetric.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Inventor: Christopher Brian Reid
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Publication number: 20140037577Abstract: The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.Type: ApplicationFiled: October 10, 2013Publication date: February 6, 2014Inventor: Michael A. Zeligs
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Publication number: 20130216574Abstract: The present invention discloses a unique kit for providing a combinational therapeutic product comprising a medical device and a pharmaceutical composition to treat mammal diseases. The medical device is to meet these unmet needs of cleansing out these harmful substances, such as viruses, multiple drug resistant bacteria, fungi, pollen, dusts, or excessive mucus. The pharmaceutical composition adds the required functions of anti-inflammatory, anti-allergy, anti-cancer, promoting membrane healing or immunomodulating, to have the added effect of the medical device. The method of using the combinational product is also disclosed. The new product can be used to prevent and treat a variety of diseases, such as common cold, drug resistant influenza, sinusitis, post nasal drip, virus-triggered asthma, or chronic obstructive pulmonary disease. In addition, the new kit and the process of use are safe and cost effective.Type: ApplicationFiled: February 20, 2012Publication date: August 22, 2013Inventor: James Liu
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Patent number: 8389021Abstract: Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating acute wounds, chronic wounds and/or a wound or epithelial tissue surface that contains bacterial biofilm, including unexpected synergy between bismuth-thiol (BT) compounds and certain antibiotics, to provide topical formulations including antiseptic formulations, for management and promotion of wound healing and in particular infected wounds. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating gram-negative bacterial infections.Type: GrantFiled: February 3, 2010Date of Patent: March 5, 2013Assignee: Microbion CorporationInventor: Brett Hugh James Baker
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Publication number: 20110195108Abstract: An antiviral agent is provided which can inactivate a wide range of viruses. Products that include such an antiviral agent are also provided. The present invention provides an antiviral agent that contains as an active ingredient a particle of at least one kind of iodide composed of iodine and an element shown in Period 4 to Period 6 and Group 8 to Group 15 of a periodic table or at least one kind of monovalent copper compound. The antiviral agent of the present invention can be designed at a higher degree of freedom in terms of its constituents as compared to conventional antiviral agents. In addition, the antiviral agent can readily exhibit and maintain its antiviral activity because it doesn't require any pretreatments or special washing processes.Type: ApplicationFiled: August 31, 2009Publication date: August 11, 2011Inventors: Yoshie Fujimori, Tsuruo Nakayama, Tetsuya Sato
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Publication number: 20110135735Abstract: The invention relates to a process for production of a composite material having antimicrobial activity, having the following steps: provision of a metal powder produced from a metal having antimicrobial activity, wherein the metal powder is formed from discrete agglomerates having a porosity of 30 to 98%, wherein the agglomerates have a spongy structure formed by solid material bridges; melting a thermoplastic and setting a predetermined viscosity; mixing the metal powder with the molten thermoplastic in a predetermined quantitative ratio; and cooling the mixture, wherein the metal powder is firmly bound to a matrix formed by the plastic.Type: ApplicationFiled: June 25, 2009Publication date: June 9, 2011Applicant: BIO-GATE AGInventor: Peter Steinruecke
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Publication number: 20100189806Abstract: Methods of growing and harvesting multiple species of phytoplankton are disclosed herein. The method generally includes four steps, namely: (1) collecting phytoplankton seawater containing multiple species of naturally-occurring phytoplankton directly from a source of seawater; (2) adding nutrients to the phytoplankton seawater to proliferate the multiple species of naturally-occurring phytoplankton to a predetermined density; (3) separating the multiple species of naturally-occurring phytoplankton from the phytoplankton seawater to form a phytoplankton concentrate; and (4) collecting the phytoplankton concentrate such that the collected phytoplankton of the phytoplankton concentrate remain in a substantially intact cellular state.Type: ApplicationFiled: October 21, 2009Publication date: July 29, 2010Inventors: Margaret Harper, Arturo Ramirez
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Patent number: 7744867Abstract: The various embodiments of the present invention are directed to pentavalent antimonials, purified pentavalent antimonials, and pentavalent antimonials that are comprised of an antimonial portion and an organic moeity portion. Alternatively the present invention is directed to agents and methods of screening agents which mimic the activity of pentavalent antimonials, particularly sodium stibogluconate and glucatime. An appropriate organic moeity may be selected based upon a desired interaction (e.g. steric action) with active site of a cellular component (e.g. a PTPase). In a preferred embodiment of the present invention the active site includes a cysteine residue which may be impacted by the compositions of the present invention.Type: GrantFiled: May 31, 2002Date of Patent: June 29, 2010Assignee: The Cleveland Clinic FoundationInventor: Taolin Yi
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Publication number: 20100055201Abstract: The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.Type: ApplicationFiled: October 26, 2007Publication date: March 4, 2010Inventor: Michael A. Zeligs
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Publication number: 20090214658Abstract: A medicinal preparation useful for treating viral diseases and for prophylaxis of various diseases—including zoonotic diseases—along with methods of using the same, is described. The preparation comprises a fine crystalline antimony silicate-based sorbent of the compositional formula xA2O.ySb2O5.zSiO2, wherein x is between 0.5 and 3, y is between 0.5 and 1.5, z is between 0.5 and 4; and A is H, Na, K, Rb, Cs. The sorbent particles are between 0.1 and 100 ?m in diameter. Between 100 and 120 mg/kg of sorbent may be administered intravenously, intramuscularly, or orally (e.g., via capsules).Type: ApplicationFiled: April 10, 2008Publication date: August 27, 2009Inventors: Gritsenko Anatoly Grigor'evich, Bratislav Jovanovic
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Publication number: 20080299160Abstract: A simple and cost effective method of producing a polymer composite comprising a polymer matrix having metal nanoparticles incorporated therein comprises the steps of (i) mixing metal nanoparticles with a polymer dope; and (ii) solidifying the polymer composite from the dope. Antimicrobial fibres are produced by extruding a dope solution (1) held in a container (2) provided with an inert atmosphere (3) into a coagulating bath (4) containing a coagulant (5), by means of a pump (6) and a spinneret head (7) completely immersed in the coagulant. The dope is filtered via a filter (8) positioned behind the spinneret.Type: ApplicationFiled: January 27, 2005Publication date: December 4, 2008Inventors: Ochayi C. Agboh, Michael J. Pitkethly
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Patent number: 7416723Abstract: In one embodiment, a therapeutic composition containing a pentavalent antimonial is provided. The pentavalent antimonial can be sodium stibogluconate, levamisole, ketoconazole, and pentamidine and biological equivalents of said compounds. Additionally, pentavalent antimonials that can be used in accordance with the present invention may be any such compounds which are anti-leishmaniasis agents. The therapeutic composition of this embodiment contains an effective amount of pentavalent antimonial that can be used in treating infectious diseases. The types of diseases that can be treated with the present invention include, but are not limited to, the following: diseases associated with PTPase activity, immune deficiency, cancer, infections (such as viral infections), hepatitis B, and hepatitis C. The types of cancers that the present embodiment can be used to treat include those such as lymphoma, multiple myeloma, leukemia, melanoma, prostate cancer, breast cancer, renal cancer, bladder cancer.Type: GrantFiled: September 9, 2002Date of Patent: August 26, 2008Assignee: The Cleveland Clinic FoundationInventor: Taolin Yi
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Patent number: 7357949Abstract: The invention relates to a microcapsule comprising an inorganic antimicrobial agent coated with a hydrophilic polymer. The hydrophilic polymer is able to absorb sufficient water as to enable the action of the encapsulated antimicrobial agent. These microcapsules are useful to impart antimicrobial activity and can be used in polymer compositions, sprays and coatings. A method of preparing the microcapsule by treatment of the antimicrobial agent with a solution of the hydrophilic polymer is provided. Another embodiment of the invention is a method of preparing the microcapsule by coating of the antimicrobial agent with a polymer precursor followed by treatment with a reactive ingredient. Another embodiment of the invention is a method of preparing the microcapsule by melt compounding the antimicrobial agent with the hydrophilic polymer followed by grinding to the desired particle size. Polymer compositions comprising the microcapsules and a matrix polymer are also provided.Type: GrantFiled: December 21, 2001Date of Patent: April 15, 2008Assignee: Agion Technologies Inc.Inventors: Jeffrey A. Trogolo, Frank C. Rossitto, Edward K. Welch, II
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Patent number: 7354605Abstract: According to the present invention there are provided antimicrobial catheters and other medical devices having controlled release of an antimicrobial metal or metal ion. Specifically, antimicrobial catheters and other medical devices manifest antimicrobial properties as a result of the incorporation therein of antimicrobial microcapsules comprising an inorganic antimicrobial agent and a hydrophilic polymer.Type: GrantFiled: January 20, 2006Date of Patent: April 8, 2008Assignee: Aglon Technologies Inc.Inventors: Jeffrey A. Trogolo, Frank C. Rossitto, Edward K. Welch, II
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Patent number: 7008647Abstract: The invention relates to the use of one or more antimicrobial metals selected from silver, gold, platinum, and palladium but most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of a acne. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.Type: GrantFiled: April 23, 2001Date of Patent: March 7, 2006Assignee: Nucryst Pharmaceuticals Corp.Inventors: Robert Edward Burrell, Hua Qing Yin
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Patent number: 6989156Abstract: Therapeutic treatments using the direct application of selected structures of antimicrobial metals in free-standing powder form, solution form and/or suspension form in therapeutically effective amounts. The selected structures of antimicrobial metals serve as an antimicrobial agent, an anti-inflammatory agent, an immuno modulator agent, an enzyme modulator agent, and/or an anti-tumor agent, for human and/or animal use.Type: GrantFiled: April 23, 2002Date of Patent: January 24, 2006Assignee: Nucryst Pharmaceuticals Corp.Inventor: Scott H. Gillis
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Patent number: 6939568Abstract: The invention relates to the use of one or more antimicrobial metals, most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of inflammatory skin conditions. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.Type: GrantFiled: April 23, 2002Date of Patent: September 6, 2005Assignee: Nucryst Pharmaceuticals Corp.Inventors: Robert Edward Burrell, Hua Qing Yin
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Patent number: 6905711Abstract: An antimicrobial agent includes an oligodynamic metal ion in a hydrophilic polymer binder or carrier. According to a presently preferred embodiment, the metal ion is silver and the hydrophilic polymer is polyurethane. According to a method of the invention, the antimicrobial agent is dissolved in dimethyl acetamide DMA, applied to paper by squeegee or the like and dried in an oven to flash off the solvent. The antimicrobial agent can be applied to other products by spraying and/or dipping and then drying to flash off solvent. A method of rendering a polymeric medical device antimicrobial is also disclosed.Type: GrantFiled: May 2, 2002Date of Patent: June 14, 2005Assignee: Smart Anti-Microbial Solutions, LLCInventors: Louis J. Tullo, Leonard Pinchuk
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Publication number: 20040161428Abstract: Conjugates of transferrin or transcobalamin with anti-protozoan drugs are useful in the treatment of protozoan infections. Suitable anti-protozoan drugs include apoptosis inducing compounds, a cytotoxic antibiotic, an alkalating agent, a plant toxin, and a bacteria mutant toxin. Transferrin or transcobalamin is preferably coupled to the anti-protozoan drug by means of glutaraldehyde.Type: ApplicationFiled: November 17, 2003Publication date: August 19, 2004Inventor: W. Page Faulk
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Patent number: 6764692Abstract: A method of treating laminitis in a horse is disclosed, comprising administering to the horse a naturally chelated trace mineral composition; promoting healthy skin, hair and hoof tissue. A method of reducing dietary intake is also disclosed, comprising administering to a horse in need thereof, effective amounts of a naturally chelated trace mineral composition. A method of preparing the chelated trace mineral composition from ocean seabed rock is further disclosed, as well as the chelated trace mineral composition.Type: GrantFiled: August 27, 2002Date of Patent: July 20, 2004Inventor: Carlos Cortelezzi
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Patent number: 6723350Abstract: The invention provides methods and kits to form water swellable gel coatings, preferably lubricious coatings, on substrates, and coated substrates thus formed. The coatings contain one or more antimicrobial metals formed with atomic disorder, together with one or more antimicrobial metals formed with atomic disorder such that the coatings provide an antimicrobial and anti-inflammatory effect when wet. The invention also provides a method to produce metal powders by sputtering a coating onto a moving surface, and then scraping the coating with one or more scrapers to produce the metal powder. The method is particularly useful for producing large amounts of nanocrystalline antimicrobial metal powders formed with atomic disorder, useful in the water swellable gel coatings of this invention.Type: GrantFiled: April 23, 2002Date of Patent: April 20, 2004Assignee: Nucryst Pharmaceuticals Corp.Inventors: Robert Edward Burrell, Hua Qing Yin, Antony George Naylor, Peter Howard Moxham, Walter Carlton Theodore Cholowski, Leonard Salvin Bowlby, David James Field
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Patent number: 6630172Abstract: Disinfectant formulations are described which are preferably ecologically friendly and non-toxic to mammals and plants, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having at least one metal ion which is microbicidal to at least one microorganism and potassium sodium tartrate in some form. When potassium sodium tartrate is used with these metal ions, it enhances the complex-forming properties of such metal complexes while concurrently increases their efficacy and potency at the same level of metal ion concentrations. These microbicidal formulations can be diluted in suitable proportions into aqueous systems to produce the desired dosages for each individual case, depending on the level and the severity of the contamination. The microbicidal formulations can be applied by conventional methods, e.g., spraying, soaking, fogging, impregnation, and the like.Type: GrantFiled: January 22, 2001Date of Patent: October 7, 2003Inventor: Kareem I. Batarseh
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Publication number: 20030161893Abstract: The present invention relates to protein tyrosine phosphatase (“PTPase”) inhibitors, and the use of PTPase inhibitors and PTPase inhibitors in combination with cytokines to treat diseases. Leishmaniasis agents have surprisingly and unexpectedly been found to be potent PTPase inhibitors. Examples of leishmaniasis agents that are also PTPase inhibitors include, but are not limited to, pentavalent antimonial compounds, imidazole compounds, and diamidine compounds. Therapeutic compositions and methods are provided that make use of these compounds to treat diseases.Type: ApplicationFiled: January 30, 2003Publication date: August 28, 2003Inventor: Taolin Yi
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Patent number: 6579541Abstract: The invention relates to a method and composition for destroying or inhibiting proliferation of microbes using oxidative fluorinator compounds. Fluoride salts that do not dissociate completely in aqueous solutions, such as tri- or tetravalent transition metal fluorides, inert gas fluorides, or tri- or tetravalent rare earth fluorides, are effective antimicrobial agents even at levels up to about 20 ppm, when used alone or in conjunction with a strong oxidizer.Type: GrantFiled: March 16, 2001Date of Patent: June 17, 2003Assignee: Marantech Holding, LLCInventor: Marvin S. Antelman
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Patent number: 6541038Abstract: A method for treating wood, characterized by impregnating wood with a metal-containing treating agent containing lignin and/or lignin derivatives and a metal, a metal compound, and/or a metal ion and oxidizing and/or macromolecularizing of the lignin and/or lignin derivatives in the wood to fix the metal component in the wood, and wood and woody materials obtained by the treating method. According to the method of the present invention, while effectively utilizing lignins, lignosulfonic acids, or lignosulfonic acid salts, leaching of the metal component can be suppressed to a low level to thereby retain the effects due to the incorporation of the metal components for a prolonged period.Type: GrantFiled: May 25, 2000Date of Patent: April 1, 2003Assignee: SDS Biotech K.K.Inventors: Keijitsu Tanaka, Hirobumi Aoki, Takashi Echigo
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Patent number: 6129924Abstract: The invention relates to an organometallic complex obtainable by reaction:of a cation of a metal (M) in an oxidation state at least equal to 2 useful as a biocatalyst in living metabolism,of a mixture of sitosterol and sitostanol, or of pure sitostanol or of a plant extract containing same,of the diglyceride of formula (I): ##STR1## in which: R.sub.1 is an acyl residue of oleic acid (C.sub.18 :1),R2 in an acyl residue of a linear or branched, saturated or unsaturated fatty acid having between 2 and 18 carbon atoms. More particularly, the invention relates to complexes in which R.sub.2 is an oleoyl or acetyl group. The invention also relates to pharmaceutical compositions containing this complex, particularly those wherein the metal is vanadium, and to their use in the treatment and/or the prevention of hypercholesterolaemia and/or of hypertriglyceridaemia, of insulin-dependent or non insulin-dependent diabetes, of insulin resistance and associated pathologies.Type: GrantFiled: July 13, 1998Date of Patent: October 10, 2000Assignee: Maurel SanteInventors: Jean-Claude Maurel, Jean-Marc Chapuis, Jean-Jacques Mongold, Nicolas Jouy
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Patent number: 5997911Abstract: A composition and method for reducing the incidence of Poult Enteritis Mortality Syndrome in young turkeys, flushing in mature turkeys, and scours in swine. The composition of the present invention comprises, in combination, a simple copper (II) salt, a hydroxycarboxylic acid, and a buffering agent solubilized within the drinking water of turkeys and/or swine in an antidiarrheal effective dosage as preventative maintenance in avoiding the diarrheal conditions associated with PEMS, flushing, and scours. In a preferred embodiment, the simple copper (II) salt comprises copper sulfate pentahydrate, the hydroxycarboxylic acid comprises anhydrous citric acid, and the buffering, agent comprises ammonium carbonate.Type: GrantFiled: August 27, 1996Date of Patent: December 7, 1999Assignee: Brinton Veterinary Supply, Inc.Inventors: Gene Brinton, Jackie Brinton Mourning
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Patent number: 5916356Abstract: This invention relates to preservative compositions which comprise a biocidal metal compound and an fungicidal compound containing a triazole group. Methods of treating wood with the composition are also described.Type: GrantFiled: June 2, 1997Date of Patent: June 29, 1999Assignee: Hickson International PLCInventors: Gareth Williams, Judith Ann Cornfield, Janet Brown, Neil Patrick Ryan
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Patent number: 5814309Abstract: Transparent aerosol antiperspirant compositions comprising an active antiperspirant salt, a carrier capable of solubilizing the active antiperspirant salt and having an effective solubility parameter of about 11 to about 13, and a liquified hydrocarbon gas propellant are disclosed.Type: GrantFiled: September 27, 1996Date of Patent: September 29, 1998Assignee: Helene Curtis, Inc.Inventor: Maximo M. Panitch
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Patent number: 5102670Abstract: The invention relates to a method for treating or preventing ocular swelling and corneal-conjunctival inflammation. This is accomplished by administering to the eye of a subject, either before or after exposure to an ocular swelling stimulus, an amount of a heme oxygenase inducing agent sufficient to increase levels of heme oxygenase in the eye and thereby to reduce or to regulate the amount of 12(R) hydroxyeicosatetraenoic and 12(R) DiHETE acids present. Particularly preferred agents include stannous compounds, such as SnCl.sub.2, other metals, heme derivatives and Vitamin B12. These compounds may be administered in various forms.Type: GrantFiled: September 14, 1990Date of Patent: April 7, 1992Inventors: Nader G. Abraham, Michal L. Schwartzman, Michael W. Dunn, Richard D. Levere