Aluminum Oxide Patents (Class 424/691)
  • Patent number: 9017733
    Abstract: The present invention relates to bioactive hetero-coagulated mixed materials that have high strength and durability, that are prepared using an aqueous process, and that have a high transparency when placed into a monomer, polymer, or resin of approximately the same refractive index.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: April 28, 2015
    Inventors: Joseph F. Bringley, Patrick M. Lambert
  • Patent number: 8980330
    Abstract: Provided is a method that enables a calcium silicate-based material to be produced more efficiently. The method of producing a calcium silicate-based material comprises: (1) a step of obtaining a reaction product by reacting raw materials containing a calcium component, a silicon component and an aluminum component in an aqueous medium; and (2) a step of forming calcium silicate by subjecting the reaction product to hydrothermal treatment.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: March 17, 2015
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Koh Konishi, Yuta Tsumura, Seiki Shinomiya, Masashi Konishi, Yukinori Konishi
  • Patent number: 8932569
    Abstract: Compositions and methods are disclosed for preventing or reducing frizzy appearance of keratin fibers, including hair, and reducing the amount of fly-away strands of hair, particularly in humid conditions, by forming a coating on hair that is resistant to water vapors from the air or surrounding environment. The compositions comprise a combination of a hydrophobic particulate material comprising a hydrophobically surface-modified aluminum oxide and one or more hydrophobic film formers in a cosmetically acceptable vehicle.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: January 13, 2015
    Assignee: Avon Products, Inc.
    Inventors: Mark S. Garrison, Freda E. Robinson, Giovana A. Sandstrom, Kenneth A. Buckridge, Sen Yang, Xiaochun Luo
  • Publication number: 20140255458
    Abstract: According to an aspect of the invention, injectable bulking compositions are provided which contain the following: (a) fibers that are configured to prevent migration to locations in the body remote from the injection site, for example, because they have a minimum length that is sufficiently large to prevent migration of the fibers and/or because they have surface features that stimulate host tissue response to lock the fibers in position and (b) a carrier in an amount effective to render the composition injectable.
    Type: Application
    Filed: May 20, 2014
    Publication date: September 11, 2014
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Jianmin Li, Michael Madden
  • Patent number: 8771661
    Abstract: This invention relates to high surface area materials, such as nanoparticles, that are coated with metal ions. These modified nanoparticles have active sites that bind various gases and/or odorous compounds, thereby removing these compounds from a medium such as air or water. Metal ions are adsorbed onto the surface of the nanoparticle and bound strongly to the surface. By selection of the metal ion, specific gaseous compounds and/or odorous compounds can be targeted and removed efficiently and effectively from both aqueous phase and from the air. The modified nanoparticles are useful in numerous article of manufacture for industrial and consumer use.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: July 8, 2014
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventor: John Gavin MacDonald
  • Publication number: 20140178502
    Abstract: When a rock powder which contains silicic acid and aluminum oxide as active ingredients is given to livestock animals, nitrogen compounds including ammonia nitrogen and nitrate nitrogen generated in the body of the livestock animals can be chemically adsorbed by aluminum oxide and silicic acid, whereby the over-absorption of the nitrogen compounds through the digestive tract can be suppressed. At the same time, minor elements contained in the rock powder act to fully elicit the activity of a nutritional component capable of suppressing mastitis, e.g., vitamin A, vitamin E, copper, zinc and manganese obtained from the feed. In this manner, the onset of mastitis can be suppressed in a nutritional manner, and a therapeutic effect can be achieved on mastitis that has already been developed.
    Type: Application
    Filed: January 30, 2014
    Publication date: June 26, 2014
    Applicant: FLORAL MINERAL CORPORATION RESEARCH LABORATORY
    Inventor: Shintaro INOUE
  • Publication number: 20140170106
    Abstract: The methods and compositions disclosed herein are effective in the promoting the reattachment of delaminated cartilage to bone. The methods (and related compositions) comprise the removal of the acellular layer of the delaminated cartilage thereby exposing the underlying chondrocyte cells thereby allowing the promotion of the reattachment of the delaminated cartilage.
    Type: Application
    Filed: November 8, 2013
    Publication date: June 19, 2014
    Inventors: Kelsey Jean Carvell, Ruth Cheng, Graham Smith, Drew Burdon
  • Publication number: 20130302424
    Abstract: The purpose of the present invention is to reduce the amounts of nitrate nitrogen and ammonia, which can be absorbed through the digestive tract and are factors for causing mastitis in livestock animals, thereby reducing the incidence rate of mastitis. A composition for preventing and treating mastitis for livestock animals comprises a rock powder containing silicic acid and aluminum oxide as active ingredients. When the composition is mixed with feed and the feed is given to livestock animals, nitrogen compounds including ammonia nitrogen and nitrate nitrogen generated in the body of the livestock animals can be chemically adsorbed by aluminum oxide and silicic acid, whereby the over-absorption of the nitrogen compounds through the digestive tract can be suppressed. At the same time, minor elements contained in the rock powder act to fully elicit the activity of a nutritional component capable of suppressing mastitis, e.g., vitamin A, vitamin E, copper, zinc and manganese obtained from the feed.
    Type: Application
    Filed: June 21, 2012
    Publication date: November 14, 2013
    Applicant: FLORAL MINERAL CORPORATION RESEARCH LABORATORY
    Inventor: Shintaro Inoue
  • Publication number: 20130302439
    Abstract: The subject matter of the invention relates to the use of a composition comprising at least one oxide and/or hydroxide insoluble in an aqueous environment, preferably selected from silicon dioxide (SlO2), titanium dioxide (TlO2), aluminium oxide (AI2O3) and aluminium hydroxide (Al(OH)3), magnesium oxide (MgO), to reduce absorption of the ethanol ingested through the consumption of alcoholic beverages. The invention also comprises the use of food products comprising these mixtures for the aforesaid use.
    Type: Application
    Filed: December 1, 2011
    Publication date: November 14, 2013
    Inventors: Alessandro Farinato, Dario Brunello, Luca Tombolan, Alfredo Guerrato
  • Patent number: 8551533
    Abstract: An adjuvant composition is provided which comprises: (a) at least one water-soluble electrolyte; (b) at least one electrolyte-tolerant surfactant; (c) antifoam component which is at least one mixture selected from the group consisting of (1) at least one branched silicone resin (i), at least one silicone fluid (ii), at least one particulate metal oxide (iii) and, optionally, at least one catalyst (iv) for catalyzing the condensation of siloxy groups, (2) the equilibration reaction product of mixture (1), and (3) mixture (1) in which at least a portion of particulate metal oxide (iii) is pre-hydrophobized; (d) optionally, at least one additional bioinert material; and, (e) water.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: October 8, 2013
    Assignee: Momentive Performance Materials Inc.
    Inventors: William L Brown, Kalman Koczo, George A Policello
  • Publication number: 20130238065
    Abstract: A phase change formulation includes a reversible phase change material and a thermal conductivity additive formulated for application to a user's epidermis.
    Type: Application
    Filed: March 6, 2012
    Publication date: September 12, 2013
    Applicant: EXERT CO.
    Inventor: Arvind M. Rao
  • Publication number: 20130103120
    Abstract: There is disclosed therapeutic devices or sanitary articles intended for the treatment of diseases and/or disorders of the tonic/postural system, containing a composition which emits and/or reflects light energy in the far infrared spectrum and which includes a ceramic material. Also disclosed is the use of a composition which emits and/or reflects light energy in the far infrared spectrum and which includes a ceramic material in the preparation of therapeutic devices or sanitary articles intended for the treatment of diseases and/or disorders of the tonic/postural system, in particular, orthodontic devices, glasses and plasters.
    Type: Application
    Filed: June 29, 2011
    Publication date: April 25, 2013
    Inventor: Sergio Ettore Salteri
  • Patent number: 8383532
    Abstract: The glass flake of the present invention has a composition that includes, in terms of mass %, 60<SiO2?65, 8?Al2O3?15, 47?(SiO2—Al2O3)?57, 1?MgO?5, 18?CaO?30, 0<Li2O?4, 0<(Li2O+Na2O+K2O)?4, and 0?TiO2?5, and that is substantially free from B2O3, F, ZnO, BaO, SrO, and ZrO2.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: February 26, 2013
    Assignee: Nippon Sheet Glass Company, Limited
    Inventors: Kosuke Fujiwara, Akihiro Koyama, Koichi Sakaguchi
  • Patent number: 8328917
    Abstract: The present invention relates to an air filtration system and a method for making a photocatalytic oxidation substrate by powder coating a photocatalyst onto a metal substrate.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: December 11, 2012
    Assignee: Garfield Industries, Inc.
    Inventors: Kirk Garfield, John Potter
  • Publication number: 20120301529
    Abstract: The present invention refers to the use of a powder of vitreous composition, characterised in that it has a minimum CaO content of 10% by weight, as biocide
    Type: Application
    Filed: December 7, 2010
    Publication date: November 29, 2012
    Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    Inventors: Jose Moya Corral, Leticia Esteban, Carlos Pecharroman, Francisco Malpartida
  • Patent number: 8298582
    Abstract: A polysaccharide-based solid material including, in its mass, at least one active agent having bactericidal, fungal, insecticidal and/or flame-retardant properties, and at least one complexing agent and/or at least one polymeric matrix having a complexing agent. The active agent includes at least one compound selected from the group including boron, silica, aluminum, phosphorus, iodine, derivatives thereof, aluminosilicate derivatives, and mixtures thereof. The solid material is characterized by an improved stability and by reduced environmental impact, and makes it possible to prepare materials based on wood particles and woods having a particular resistance against environmental attacks such as moisture.
    Type: Grant
    Filed: March 28, 2007
    Date of Patent: October 30, 2012
    Assignee: Hydro-Quebec
    Inventors: Louis Gastonguay, Michel Perrier, Paul-Étienne Harvey, Jean-François Labrecque, Michel Robitaille, André Besner
  • Patent number: 8293257
    Abstract: An oily dispersion of an inorganic microparticle oxide powder that exhibits excellent texture has superior compatibility with other cosmetic material components. The oily dispersion contains only two components of a dispersion medium and a surface-treated inorganic microparticle oxide powder, wherein the dispersion medium is an oil, the surface-treated inorganic microparticle oxide powder is a powder surface-treated with branched fatty acid containing isostearic acid as a primary constituent component or a metal salt containing isostearic acid as a primary constituent component at an amount of 1 to 30% by weight with respect to the powder as a base material, and the surface-treated inorganic microparticle oxide powder has a solid concentration of 25% by weight or more and a viscosity of 2,000 mPa·s or less at 25° C. in the preparation of the oily dispersion.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: October 23, 2012
    Assignee: Tayca Corporation
    Inventors: Kazunori Yagi, Naoki Kanda
  • Publication number: 20120251450
    Abstract: Of the many compositions and methods provided herein, one composition includes a nanoparticle having a first oxide of a first metal and a dopant that includes an ion or an atom of a second metal. A method includes a method comprising providing a plurality of nanoparticles comprising a first oxide of a first metal and a dopant that comprises an ion or an atom of a second metal; providing a diseased cell and a healthy cell; contacting the diseased cell and the healthy cell with the nanoparticle; and allowing the nanoparticle to preferentially associate with the diseased cell.
    Type: Application
    Filed: April 4, 2011
    Publication date: October 4, 2012
    Inventors: Alex Punnoose, Denise Wingett
  • Publication number: 20120244224
    Abstract: A method of inducing mineralization in a bone cell is described. The method comprises contacting a bone cell with a composition comprising nanoparticles. The nanoparticles can be single-walled carbon nanotubes, hydroxyapatite nanoparticles, TiO2 nanoparticles or silver nanoparticles. The bone cell can be an osteoblast cell. A method for increasing bone mass, bone healing or bone formation is also described which comprises administering to a subject in need thereof an effective amount of a composition comprising nanoparticles. The subject can suffer from a bone disease such as osteoporosis. The subject can suffer from a bone fracture and the method can comprise contacting bone cells near the bone fracture site with the composition. The composition can further comprise a pharmaceutically acceptable carrier.
    Type: Application
    Filed: March 21, 2012
    Publication date: September 27, 2012
    Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Alexandru S. BIRIS, Daniel CASCIANO, Meena Waleed MAHMOOD
  • Publication number: 20120237566
    Abstract: The present invention relates to improved methods of preventing or inhibiting the release of acid in the stomach, which are uniquely reversible at the cellular level, through the use of organic isothiocyanates and thiocyanates with divalent cations such as barium, zinc and calcium for human and veterinary applications. The present invention also relates to methods of preventing or treating persistent chronic gastritis, GERDs, ulcer and or stomach cancer by inhibiting the release of stomach acid and by reducing inflammation with fewer and milder side-effects expected than current treatments. A method of screening therapeutics is described.
    Type: Application
    Filed: March 15, 2012
    Publication date: September 20, 2012
    Applicant: Venture Isles, LLC
    Inventors: Tushar K. Ray, Clyde G. Hanson, Paul Burgio
  • Patent number: 8216614
    Abstract: A composition comprising a powder mixture of potassium citrate and calcium citrate as mixtures of pure chemical salts and methods of making and using the composition are disclosed. The composition is useful for the treatment and prevention of kidney stones and osteoporosis and better delivers potassium and calcium than commonly used potassium and calcium supplements.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: July 10, 2012
    Assignee: The Board of Regents of the University of Texas Systems
    Inventors: Charles Y. C. Pak, Khashayar Sakhaee, Neill B. Walsdorf, Sr.
  • Publication number: 20120128748
    Abstract: Organic-inorganic composite particles includes inorganic oxide particles each of which has a cationic charge on the particle surface and polymer gel molecules which are derived from a natural substance, have an anionic functional group and one or more hydroxyl groups in a molecule and have both a shrinking and a swelling property, the polymer gel molecules are electrostatically bonded to surfaces of the inorganic oxide particles; a process for producing the particles; a dispersion containing the particles; and a cosmetic containing the particles. These organic-inorganic composite particles have good dispersibility not only in aqueous solvents such as water but also in non-aqueous solvents and further have characteristics that aggregation of the particles scarcely occurs.
    Type: Application
    Filed: July 30, 2010
    Publication date: May 24, 2012
    Applicant: JGC CATALYSTS AND CHEMICALS LTD.
    Inventors: Kensuke Nagata, Michio Komatsu
  • Patent number: 8182800
    Abstract: This invention relates to high surface area materials, such as nanoparticles, that are coated with metal ions. These modified nanoparticles have active sites that bind various gases and/or odorous compounds, thereby removing these compounds from a medium such as air or water. Metal ions are adsorbed onto the surface of the nanoparticle and bound strongly to the surface. By selection of the metal ion, specific gaseous compounds and/or odorous compounds can be targeted and removed efficiently and effectively from both aqueous phase and from the air. The modified nanoparticles are useful in numerous article of manufacture for industrial and consumer use.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: May 22, 2012
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventor: John Gavin MacDonald
  • Publication number: 20120087877
    Abstract: The invention relates to a composition based on mineral concentrates and a method of preparing this composition. The composition comprises a powder or a mixture of powders containing at least one silicon derivative and at least one trace element other than silicon, as a mixture with a carrier and physiologically acceptable excipients. Application in cosmetology and dermatology for protecting the skin.
    Type: Application
    Filed: October 14, 2011
    Publication date: April 12, 2012
    Applicant: BULGARI PARFUMS
    Inventors: Jean-Claude ALLART, Jean-Marie Lefevre, Jacques Peyrot, Jean-Paul Marty
  • Publication number: 20110262560
    Abstract: A pigmented emulsion composition comprising a water phase, an oil phase, and a plurality of gemstones in particulate form, and a method for providing a glow to the skin and ameliorating the appearance of wrinkles, lines, and skin discoloration by applying a pigmented emulsion composition comprising a plurality of gemstones.
    Type: Application
    Filed: February 17, 2009
    Publication date: October 27, 2011
    Inventors: Michelle L. Dabe, Weilin Mu, George J. Stepniewski
  • Publication number: 20110256194
    Abstract: The present invention relates to a pearl pigment obtained by coating the surface of a flaky powder with a colored metal or a colored metal oxide and further coating the surface of the above colored metal- or colored metal oxide-coated flaky powder with a colorless metal or a colorless metal oxide, wherein when the pearl pigment is applied onto the surface of black artificial leather in an average amount of 0.05 mg/cm2 and the intensity of light reflected from the pearl pigment is measured using illuminant C at a 2° viewing angle with a spectrophotometric colorimeter which is provided with a sheet polarizer S on the light incident side and a sheet polarizer P on the light receiving side, the powder reflection light which is incident to the pearl pigment as a measurement sample at an angle of 45° to the direction normal to the surface of the sample and is received in the direction normal to the surface of the sample has absolute values a* and b* of 10 or less, and make-up cosmetics containing the pearl pigment.
    Type: Application
    Filed: June 28, 2011
    Publication date: October 20, 2011
    Applicants: Nihon Koken Kogyo KK, Kao Corporation
    Inventors: Eiichiro MISAKI, Hiroyuki SHIOMI, Maoya ADACHI, Takahiro KAIDA
  • Publication number: 20110195130
    Abstract: Disclosed are various embodiments of edible food compositions effective for neutralizing stomach acid. Further, the present invention is directed toward methods of preparing the edible composition and the methods for reducing stomach acidity by ingesting the edible composition. In one embodiment, the edible composition comprises sweetener, flour, fat, leavening agent, water, and an effective amount of acid neutralizing material. In one embodiment, the above ingredients are combined to form a heavy dough which is then rolled out, divided into sections, and baked, resulting in a cookie with effective antacid properties. Further disclosed are edible compositions for delivering calcium as a dietary supplement.
    Type: Application
    Filed: February 9, 2010
    Publication date: August 11, 2011
    Inventor: Sanford Siegal
  • Publication number: 20100297039
    Abstract: The present invention provides an oil-in-water emulsion composition having excellent emulsion stability, low sticky feeling, and low skin irritation. The oil-in-water emulsion composition according to the present invention comprises (a) 1 to 20 mass % of a powder component, (b) 0.001 to 0.5 mass % of a cationic surfactant having two alkyl chains with 12 or more and 22 or less carbon atoms, (c) an oil phase component, and (d) a water phase component, having a structure that (a) powder particles are adsorbed on the oil droplets dispersed in the water phase, and containing substantively no surfactant other than the (b) cationic surfactant.
    Type: Application
    Filed: April 25, 2008
    Publication date: November 25, 2010
    Applicant: SHISEIDO COMPANY LTD.
    Inventors: Akira Ishikubo, Yuji Matsushita, Yosuke Ikebe, Taizo Fujiyama, Tomonori Toyoda, Kazuho Koiwa
  • Publication number: 20100266649
    Abstract: A gel system comprising a fractal network of nanoparticles and macroscopic particles is disclosed. The gel system is capable of forming an “optical gel” effective to blurrfine lines and wrinkles as a consequence of the size domain differences between the fractal particles and the macroscopic particles. Cosmetic compositions comprising such gels and methods for their use are also disclosed.
    Type: Application
    Filed: November 19, 2008
    Publication date: October 21, 2010
    Applicant: AVON PRODUCTS, INC.
    Inventors: Prithwiraj Maitra, Steven E. Brown, John R. Glynn, JR., Jason Rothouse, John C. Brahms, Michael J. Fair
  • Publication number: 20100183737
    Abstract: The glass flake of the present invention has a composition that includes, in terms of mass %, 60<SiO2?65, 8?Al2O3?15, 47?(SiO2—Al2O3)?57, 1?MgO?5, 18?CaO?30, 0<Li2O?4, 0<(Li2O+Na2O+K2O)?4, and 0?TiO2?5, and that is substantially free from B2O3, F, ZnO, BaO, SrO, and ZrO2.
    Type: Application
    Filed: June 21, 2007
    Publication date: July 22, 2010
    Applicant: NIPPON SHEET GLASS COMPANY, LIMITED
    Inventors: Kosuke Fujiwara, Akihiro Koyama, Koichi Sakaguchi
  • Patent number: 7709027
    Abstract: The invention relates to an anti-inflammatory, wound-healing glass powder, whereby the glass of the glass powder comprises the following components: 20-80 wt. % SiO2, 0-40 wt. % Na2O, 0-40 wt. % K2O, 0-40 wt. % Li2O, 0-40 wt. % CaO, 0-40 wt. % MgO, 0-40 wt. % Al2O3, 0-1 wt. % P2O5, 0-40 wt. % B2O3 and 0-10 wt. % ZnO.
    Type: Grant
    Filed: August 17, 2002
    Date of Patent: May 4, 2010
    Assignee: Schott AG
    Inventors: Jörg Hinrich Fechner, José Zimmer
  • Publication number: 20100098780
    Abstract: The present invention has an object to provide a flaky particulate material giving skin an excellent smoothness, which is free from whitening problem upon use thereof owing to its high transparency. The present invention also has another object to provide a cosmetic composition containing the flaky particulate material. The present invention relates to flaky particulate material, which has an average coefficient of friction is not more than 0.50, and a total light transmittance is not less than 85%. A particle in the flaky particulate material comprises a substrate particle made of one material selected from the group consisting of mica, a synthetic mica, sericite, talc, barium sulfate and aluminum oxide. The present invention provides a flaky particulate material that gives skin excellent smoothness, a natural tone, and a matt appearance. The flaky particulate material of the present invention gives a cosmetic composition which provides great comfort of use, and an excellent appearance.
    Type: Application
    Filed: February 13, 2007
    Publication date: April 22, 2010
    Applicant: SAKAI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Keiji Ono, Takuro Ashida, Hiroyuki Izumikawa, Hirobumi Yoshida
  • Patent number: 7666506
    Abstract: The present invention relates to surface-modified nanoparticulate metal oxides where the metal is chosen from the group consisting of aluminum, cerium, iron, titanium, zinc and zirconium, wherein the surface modification comprises a coating with a copolymer P comprising, as monomers, A) 1 to 99 mol % of a N-vinylamide N-vinylpyrrolidone and B) 99 to 1 mol % of a monomer comprising, per molecule, a free-radically polymerizable ?,?-ethylenically unsaturated double bond and an anionogenic and/or anionic group, with the proviso that the copolymer P must comprise no further monomers chosen from the group consisting of C8-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids, N-alkyl- or N,N-dialkyl-substituted amides of acrylic acid or of methacrylic acid with C8-C18-alkyl radicals, or vinyl esters of aliphatic C8-C30-carboxylic acids.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: February 23, 2010
    Assignee: BASF SE
    Inventors: Jens Rieger, Jutta Kissel, Valerie Andre, Nathalie Bouillo
  • Publication number: 20100040701
    Abstract: A novel exfoliating compound and method for treating acne without an irritating cleanser. The compound includes a first subcompound formed from a clay based substance and a second subcompound formed an exfoliating substance selected from the group consisting of crystals, beads, polyethylene, nuts, natural rough products, corundum crystals, crushed almond shells and crushed apricot kernels.
    Type: Application
    Filed: August 10, 2009
    Publication date: February 18, 2010
    Inventor: Neal Schwartz
  • Patent number: 7638144
    Abstract: A composition including a base and a plurality of abrasive particles. An apparatus including a head, and an applicator coupled to the head, the applicator having dimensions suitable for contacting localized areas of human skin. A method including applying a composition to an area of human skin, the composition comprising a base and a plurality of abrasive particles, and manipulating the composition over the area of human skin with a handle-operated instrument.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: December 29, 2009
    Assignee: DermaNew, Inc.
    Inventor: Dean Rhaodes
  • Publication number: 20090304629
    Abstract: The present invention relates to compounds of Formula I, II or III, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: January 9, 2009
    Publication date: December 10, 2009
    Inventors: Zhenwei Miao, Ying Sun, Suanne Nakajima, Datong Tang, Frank Wu, Guoyou Xu, Yat S. Or, Zhe Wang
  • Publication number: 20090299237
    Abstract: A composition including a base and a plurality of abrasive particles. An apparatus including a head, and an applicator coupled to the head, the applicator having dimensions suitable for contacting localized areas of human skin. A method including applying a composition to an area of human skin, the composition comprising a base and a plurality of abrasive particles, and manipulating the composition over the area of human skin with a handle-operated instrument.
    Type: Application
    Filed: August 11, 2009
    Publication date: December 3, 2009
    Applicant: DermaNew, Inc.
    Inventor: Dean L. Rhoades
  • Publication number: 20090291148
    Abstract: A depilatory kit may comprise a depilatory composition comprising a sulfur-containing depilatory agent and a finishing composition comprising a metal oxide selected from the group consisting of zinc oxide, aluminum oxide, and magnesium oxide. The depilatory composition may further comprise a lactone such as 1,15-cyclopentadecanolide. Methods for using the depilatory kits are also disclosed herein.
    Type: Application
    Filed: December 18, 2008
    Publication date: November 26, 2009
    Inventors: Laurie Ellen Breyfogle, Joseph Michael Zukowski, Robert John Elsbrock
  • Patent number: 7578997
    Abstract: This invention relates to high surface area materials, such as nanoparticles, that are coated with metal ions. These modified nanoparticles have active sites that bind various gases and/or odorous compounds, thereby removing these compounds from a medium such as air or water. Metal ions are adsorbed onto the surface of the nanoparticle and bound strongly to the surface. By selection of the metal ion, specific gaseous compounds and/or odorous compounds can be targeted and removed efficiently and effectively from both aqueous phase and from the air. The modified nanoparticles are useful in numerous article of manufacture for industrial and consumer use.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: August 25, 2009
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventor: John Gavin MacDonald
  • Publication number: 20090110752
    Abstract: A composition for controlling a blood glucose and a method thereof are provided. The composition comprises a far-infrared ray releasing substance, wherein the composition reduces the blood glucose of a subject via an irradiation of the far-infrared ray releasing substance. In another aspect, the method comprises the steps of providing a far-infrared ray releasing substance having an oxide mineral as a main component, and disposing the far-infrared ray releasing substance in a place close to a subject in an appropriate distance, wherein the subject has an insulin resistance and the appropriate distance is within an irradiation range of the far infrared ray.
    Type: Application
    Filed: February 8, 2008
    Publication date: April 30, 2009
    Applicants: TAIPEI MEDICAL UNIVERSITY, NATIONAL APPLIED RESEARCH LABORATORIES
    Inventors: Huey-Fang Shang, Ting-Kai Leung, Yung-Sheng Lin, Chung-Huei Hsu
  • Publication number: 20090004280
    Abstract: A kit for skin care intended to soften cutaneous signs of ageing, contains in separate packagings, a microdermabrasion composition, a peeling composition, a soothing composition and an anti-ageing composition.
    Type: Application
    Filed: September 11, 2008
    Publication date: January 1, 2009
    Applicant: L'OREAL
    Inventor: Catherine Marion
  • Publication number: 20080226574
    Abstract: The present invention relates to a line of cosmetic compositions comprising at least two compositions each comprising a cosmetically-acceptable medium and at least one multilayer interference pigment, each composition providing coverage that is greater than or equal to 25, the respective multilayer interference pigments of the various compositions being selected in such a manner that the colors of the compositions in the mass, taken two by two, differ by a color difference ?Ebeforeapplication that is less than or equal to 3, and in such a manner that, after application, the compositions, taken two by two, present a color difference ?Eafterapplication that is greater than or equal to 5.
    Type: Application
    Filed: November 14, 2007
    Publication date: September 18, 2008
    Applicant: L'OREAL
    Inventor: Ludovic Thevenet
  • Patent number: 7311766
    Abstract: This invention relates to the use of a combination of selected substances in paint to prevent the settlement and growth of different biofouling organisms with a reduced negative effect on the ecosystems compared to present methods.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: December 25, 2007
    Assignee: I-Tech AB
    Inventors: Magnus Nydén, Camilla Fant
  • Patent number: 7294349
    Abstract: An emulsion comprising: water; hydrophilic particles; and hydrophobic particles; wherein the hydrophilic and hydrophobic particles form shells encapsulating a gas that are suspended in the water, said shells comprising an external layer of hydrophilic particles and an internal layer of hydrophobic particles adjacent to the layer of hydrophilic particles.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: November 13, 2007
    Assignee: Or Le Or Ltd.
    Inventor: Dov Ingman
  • Patent number: 7226608
    Abstract: Dispersions containing from about 0.5% to about 30% by weight dispersed microfine calcined alumina, stainless steel, or gold particles typically having particle size of less than about 5?, more narrowly 1? or less, suspended in a cosmetically acceptable carrier are useful as sunblocks for skin and hair while simultaneously providing treatments that render skin and hair smoother, more uniform, lustrous, visually appealing and healthier-looking.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: June 5, 2007
    Assignee: N.V. Perricone LLC
    Inventor: Nicholas V. Perricone
  • Patent number: 7189708
    Abstract: A topical skin composition containing a dipeptide compound represented by formula (1) or a salt of the dipeptide: wherein R1 represents a hydrogen atom, an alkyl group, an alkanoyl group, or —CH(R6)COOR7 (wherein R6 represents a hydrogen atom or a lower alkyl group, and R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group); R2 represents a hydrogen atom or an alkyl group which may have a substituent; R3 represents a lower alkyl group or a phenyl group; R4 represents a hydrogen atom or a lower alkyl group, and may form a heterocyclic ring together with R5 and an adjacent nitrogen atom; R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, and may form the heterocyclic ring together with R4; X represents —COOR8 (wherein R8 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group) or —SO3H; and n is an integer of 0-4; and a pharmaceutically acceptable carrier
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: March 13, 2007
    Assignee: Kao Corporation
    Inventors: Yasuto Suzuki, Mikako Watanabe, Naoko Tsuji, Shigeru Moriwaki, Shinya Amano
  • Patent number: 7172770
    Abstract: The present invention encompasses novel mesoporous compositions comprising vitamin E and alumina, and methods for their synthesis. The mesoporous compositions of the present invention have applications as drug-delivery vehicles.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: February 6, 2007
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ying Ma, Kenneth J. Balkus, Jr.
  • Patent number: 7037512
    Abstract: Dispersions containing from about 0.5% to about 30% by weight dispersed microfine calcined alumina, stainless steel, or gold particles typically having particle size of less than about 5?, more narrowly 1? or less, suspended in a cosmetically acceptable carrier are useful as sunblocks for skin and hair while simultaneously providing treatments that render skin and hair smoother, more uniform, lustrous, visually appealing and healthier-looking.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: May 2, 2006
    Inventor: Nicholas V. Perricone
  • Patent number: 7029705
    Abstract: A method is disclosed of practicing nasal hygiene comprising the steps of applying to a person's nostril a non-irritating hygienic composition consisting essentially of a product of compounding under homogenizing conditions water, 0.01% to 5% by weight, as chlorine dioxide, of a source of chlorine dioxide; 0.01% to 3% by weight of at least one olfactory stimulant, 0 to 5% by weight of at least one fixative compound less volatile than the olfactory stimulant 0.1 to 2.5% by weight of at least one inorganic salt selected from the group consisting of alkali metal chloride, alkali metal bicarbonate, and alkali metal chlorate; and 0.0002 to 0.006% (as aluminum) by weight of at least one water soluble aluminum compound, provided that the total concentration of inorganic salt is in the range from 0.6% by weight to 2.5% by weight, holding the composition within the nostril for a hygienic holding period, and discharging the composition from the treated nostril.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: April 18, 2006
    Inventor: Allan H. Fuhr
  • Patent number: 6958159
    Abstract: The present invention relates to an improved pharmaceutical composition useful for the topical treatment of burns, cuts, wounds, abrasions and the like, and to methods of treatment of injured body surfaces such as skin.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: October 25, 2005
    Assignee: Chiltern Pharmaceuticals, Pty Ltd.
    Inventor: Robert Alan Smith