Skin Burn Or Open Wound Treatment Patents (Class 424/78.06)
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Patent number: 6468553Abstract: The invention discloses an extract containing puccoon and Chinese angelica, and a formula and preparation method of an ointment containing the extract. The extract is used for treating burns and scalds and is characterized by superior shelf-life. The puccoon and Chinese angelica are extracted with an organic solvent having a polarity of between 0.35 and 0.95, which are then filtrated, concentrated and mixed with a physiologically acceptable carrier or excipient.Type: GrantFiled: August 3, 2000Date of Patent: October 22, 2002Assignee: Pharmaceutical Industry Technology and Development CenterInventors: Ce-Shing Sheu, Yi-Ching Wu, Jun-Hung Kuo
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Patent number: 6468508Abstract: In a system for coating human skin, a chemical composition, such as a cosmetic or medical formulation, is uniformly coated over the entire body or selected parts of the body of the person being coated. The system includes atomization of the coating composition, containment of the atomized spray, and residual recovery which together yield a novel method for applying chemical compositions. An improved self-tanning composition is useful in conjunction with system is also disclosed. Also disclosed is a method of preconditioning the skin prior to applying the self-tanning composition.Type: GrantFiled: October 2, 2000Date of Patent: October 22, 2002Assignee: Laughlin Products, Inc.Inventor: Thomas J. Laughlin
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Patent number: 6461600Abstract: A cream carrier is provided which has use as a cream-type carrier for topical delivery of medicaments including analgesics. The carrier comprises a mixture of: squalane NF, an emulsifier such as Tween 80, glycerin, cetyl alcohol NF, glyceryl monostearate, lecithin organogel preserved, BHT, urea USP, EDTA, water, stearic acid, simethicone USP, and ethoxy diglycol reagent. The invention also comprises a combination of the carrier, with either or both of ketamine hydrochloride and amitriptyline hydrochloride, which has use as a topically applied analgesic.Type: GrantFiled: July 12, 2001Date of Patent: October 8, 2002Inventor: Peter R. Ford
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Patent number: 6455064Abstract: A composition comprising a polymerizable adhesive monomer is applied over a biologically active initiator or accelerator for polymerization of the monomer. The biologically active initiator or accelerator is a medicament that provides a desired medical or therapeutic activity as well as enhancing polymerization of the adhesive.Type: GrantFiled: October 29, 1999Date of Patent: September 24, 2002Assignee: Closure Medical CorporationInventors: Upvan Narang, Daniel L. Hedgpeth, Gabriel N. Szabo, Ibraheem T. Badejo, Joe B. Barefoot
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Patent number: 6451301Abstract: The present invention provides a method of attenuating the response of nociceptors to noxious stimuli by applying a composition comprising a hydrophilic foam substrate, a polymeric hydrophilic agent capable of absorbing water to the surface of the skin. In other aspects, the present invention provides a method of preventing the formation of a bruise in traumatized tissue, a method of attenuating swelling, a method of attenuating neurogenic inflammatory response, and a method of reducing the sensation of pain by applying like compositions to the surface of the skin of patients.Type: GrantFiled: June 7, 1999Date of Patent: September 17, 2002Assignee: Ferris CorporationInventors: Robert W. Sessions, Alan R. Kahn
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Patent number: 6447802Abstract: The present invention provides a method of attenuating the formation of a bruise and a method of attenuating swelling or inflammation in the tissue of a patient via applying a composition comprising a hydrophilic foam substrate and a polymeric hydrophilic agent capable of absorbing water to the surface of the skin.Type: GrantFiled: February 20, 2001Date of Patent: September 10, 2002Assignee: Ferris CorporationInventors: Robert W. Sessions, Alan R. Kahn
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Patent number: 6432444Abstract: A bandage for treating a bacterial infection of skin is disclosed wherein the bandage contains a composition produced by the method of obtaining an effective amount of at least one lytic enzyme genetically coded for by a specific bacteriophage specific for a bacteria infecting the skin, wherein the bacteria to be treated is selected from the group consisting of Staphylococcus, Pseudomonas, Streptococcus, and combinations thereof. This lytic enzyme is specific for and has the ability to digest a cell wall of one of the bacteria and is coded for by the same bacteriophage capable of infecting the bacteria being digested. The enzyme produced is mixed with a topical carrier.Type: GrantFiled: September 28, 2000Date of Patent: August 13, 2002Assignee: New Horizons Diagnostics CorpInventors: Vincent Fischetti, Lawrence Loomis
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Patent number: 6432430Abstract: An exfoliating scrub contains in a mild cream or gel base a therapeutically effective concentration of niacinamide and an abrasive exfoliating agent, preferably powdered walnut shells. The scrub is applied topically to areas of the skin that are to be treated and is massaged into the skin. The scrub is thereafter removed. The scrub contains niacinamide in an amount between about 1 and 20% by weight.Type: GrantFiled: November 17, 2000Date of Patent: August 13, 2002Inventor: Edwin Fitzjarrell
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Patent number: 6426066Abstract: A physiologically-balanced, ionized, acidic solution. The solution may be prepared by the electrolysis of a solution comprising a mixture of inorganic salts in physiologically balanced proportions. A mixture of inorganic salts and, optionally, minerals (such as metallic elements, for example, and not by way of limitation) is used in order to mimic the electrolyte concentration and mixture of body fluid in an isotonic state. The solution typically comprises halide salts of sodium, potassium, calcium, and other cations. Typically the halide is fluoride, chloride, bromide, or iodide; and most typically chloride. The halide-comprising acidic solution is physiologically balanced by the inclusion of elements such as sodium, potassium, magnesium, zinc, lithium, and beryllium in the solution. The composition of the invention is nontoxic and has antibacterial properties.Type: GrantFiled: January 12, 2000Date of Patent: July 30, 2002Assignee: California Pacific Labs, Inc.Inventors: Ramin Najafi, Suzanne M. Bernard
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Patent number: 6419936Abstract: A topical skin ointment for application onto the skin of individuals suffering from minor skin irritations such as dry chapped skin, minor cuts, and scrapes and abrasions. The topical skin ointment includes ingredients to reduce the discomfort associated with these types of skin irritations as well ingredients to promote the natural healing process.Type: GrantFiled: June 21, 2000Date of Patent: July 16, 2002Inventor: Adell J. Schmoyer
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Patent number: 6419939Abstract: A compound for reducing the incidence of pseudofolliculitis combines a mild skin astringent, an oil based epidermal softener, and a hair stiffener. One embodiment of the compound combines refined powdered oatmeal and emollient of the compound combines refined powdered oatmeal and emollient oil, such as mink oil and liquid vitamin A in a petroleum jelly base. The mixture is applied by being massaged into the skin prior to lathering and then again immediately after the rinsing of the face after shaving. Continual usage significantly reduces the eruption of pseudofolliculitis.Type: GrantFiled: May 8, 2001Date of Patent: July 16, 2002Inventor: John Campbell
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Patent number: 6419913Abstract: This invention relates to a method for enhancing the transmembrane penetration of benefit agents using a certain non-ionic lipid/surfactant-containing formulation as an enhancing agent, and the compositions used therein. Various active agents, such as anti-dandruff agents, hair growth agents, hair inhibitor agents, anti-acne agents, anti-aging agents, depilatory agents, and depigmentation agents, may be effectively delivered into the skin, hair follicles and sebaceous glands using the compositions of the present invention.Type: GrantFiled: July 26, 2001Date of Patent: July 16, 2002Assignee: Johnson & Johnson Consumer Companies, Inc.Inventors: Susan M. Niemiec, Jonas C. T. Wang, Stephen J. Wisniewski, Kurt S. Stenn, Gwang Wei Lu
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Patent number: 6416747Abstract: In a system for coating human skin, a chemical composition, such as a cosmetic or medical formulation, is uniformly coated over the entire body or selected parts of the body of the person being coated. The system includes atomization of the coating composition, containment of the atomized spray, and residual recovery which together yield a novel method for applying chemical compositions. An improved self-tanning composition is useful in conjunction with system is also disclosed. Also disclosed is a plural component self-tanning system.Type: GrantFiled: October 2, 2000Date of Patent: July 9, 2002Assignee: Laughlin Products, Inc.Inventor: Thomas J. Laughlin
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Patent number: 6413539Abstract: The present invention provides novel hydrogel-forming, self-solvating, absorbable polyester copolymers capable of selective, segmental association into compliant hydrogels upon contacting an aqueous environment. Methods of using the novel polyester copolymers of the invention in humans are also disclosed for providing a protective barrier to prevent post-surgical adhesion, treatment of defects in conduits such as blood vessels, and controlled release of a biologically active agent for modulating cellular events such as wound healing and tissue regeneration or therapeutic treatment of diseases such as infection of the periodontium, dry socket, bone, skin, vaginal, and nail infections.Type: GrantFiled: January 29, 1998Date of Patent: July 2, 2002Assignee: Poly-Med, Inc.Inventor: Shalaby W. Shalaby
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Patent number: 6410645Abstract: Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.Type: GrantFiled: November 9, 2000Date of Patent: June 25, 2002Assignee: Focal, Inc.Inventors: Chandrashekhar P. Pathak, Shikha P. Barman, C. Michael Philbrook, Amarpreet S. Sawhney, Arthur J. Coury, Luis Z. Avila, Mark T. Kieras
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Patent number: 6406721Abstract: A salve for treating burns for reducing pain and scarring to burned skin. The salve for treating burns includes combining 3 parts of pork fat with 2 parts of chopped Hydrangea plant by weight to form a mixture. Heating the mixture at a temperature of 175 degrees Celsius until the Hydrangea plant has turned brown. Straining the mixture to define a strained mixture. Cooling the strained mixture to a temperature less than 35 degrees Celsius such that the strained mixture solidifies.Type: GrantFiled: June 22, 2001Date of Patent: June 18, 2002Inventors: Wentzel W. Owens, Ansil White, Charles Farley
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Patent number: 6395289Abstract: The invention discloses a mammalian teat dip for controlling mastitis, a method for preparing the composition and a method of treatment of mammals. The composition contains a film-forming polymer blend, at least one antimicrobial and a sodium bicarbonate buffering agent. The polymer blend contains a solvent-soluble, thermoplastic polyurethane and a hydrophilic poly(N-vinyl lactam). Upon application to mammalian skin, this composition leaves a long-lasting, water-resistant, residual, elastic film that treats and protects mammalian skin from infection.Type: GrantFiled: April 25, 2000Date of Patent: May 28, 2002Assignee: Hydromer, Inc.Inventors: Joseph Ehrhard, Michael Eknoian, Alfredo Vinci
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Patent number: 6391343Abstract: The invention provides a particle comprising fibrinogen bound on the surface of an albumin matrix, wherein said particle is capable of coaggregation with platelet, and of aggregation in a solution containing soluble fibrinogen at a concentration of soluble fibrinogen not capable by it self of formation of a clot upon activation by thrombin.Type: GrantFiled: April 10, 1998Date of Patent: May 21, 2002Assignee: Hemosphere, Inc.Inventor: Richard C. K. Yen
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Patent number: 6391323Abstract: A composition having analgesic, antiseptic and skin healing promoting activity, suitable for the treatment of burns, sunburns, scalds, irritation, sores and abrasions which includes, as active ingredients, chlorophyll, cod liver oil, and camphor, preferably together with a natural antiseptic agent chosen from niaouli oil, thyme oil, and mixtures thereof, in a pharmaceutically acceptable vehicle for topical application.Type: GrantFiled: May 23, 2000Date of Patent: May 21, 2002Inventor: Andrea Carnevali
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Patent number: 6375977Abstract: The present invention relates to a novel hydrocolloid adhesive mass useful for medical purposes, characterized in that said hydrocolloid adhesive mass comprises: a) 0.2 to 5 parts by weight of an ethoxylated sorbitan fatty acid ester; b) 20 to 50 parts by weight of a hydrocolloid; c) 32 to 120 to parts by weight of an adhesive matrix made up of one or more polymers selected from poly(styrene/olefin/styrene) block copolymers, low-molecular polyisobutylenes and high-molecular polyisobutylenes, and one or more compounds selected from sticky resins, or tackifying resins, plasticizers, polybutenes, antioxidants, ethylene/vinyl acetate copolymers, butyl rubbers and ethylene/propylene block copolymers; and d) 0 to 15 parts by weight of an acrylate copolymer with a glass transition temperature below −20° C.Type: GrantFiled: September 5, 2000Date of Patent: April 23, 2002Assignee: Laboratories d'Hygiene et de DietetiqueInventors: Stephane Auguste, Laurent Apert, Luc Garima
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Patent number: 6375942Abstract: A skin healing ointment comprises wax, petrolatum, antibiotic, zinc oxide and an anti-itch ingredient in the following proportions: Wax—0.5-5.0 parts Petrolatum—4.0-10.0 parts Antibiotic—0.25-5.0 parts Zinc oxide—up to 8.0 parts Anti-itch—up to 0.28 parts. In its preferred form, the ointment comprises, approximately: Wax—2.0 parts Petrolatum—7.0 parts Antibiotic—0.817 parts Zinc oxide—0.4 parts Anti-itch—0.05 parts. Effective treatment of psoriasis, Fifth disease, chafing, burns, chapped skin and rashes comprises application of the ointment three times daily until symptoms disappear, then once daily to keep the skin supple and prevent reoccurrence.Type: GrantFiled: August 31, 2000Date of Patent: April 23, 2002Inventor: Michael C. Rico
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Publication number: 20020042378Abstract: Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a hydrogel when exposed to blood. The non-cross-linked polymer is chosen to solubilize relatively rapidly when exposed to blood. The non-cross-linked polymer serves as a binder for holding the materials in desired geometries, such as sheets, pellets, plugs, or the like. Usually, the cross-linked polymer will be present in a particulate or fragmented form. The materials are particularly suitable for hemostasis and drug delivery.Type: ApplicationFiled: June 10, 1999Publication date: April 11, 2002Inventors: CARY J. REICH, A. EDWARD OSAWA, HELEN TRAN
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Patent number: 6365167Abstract: What is described herein is the reaction product of arginine and p-aminobenzoic acid (PABA), cosmetic and human and animal health compositions thereof, useful for treating wounds (small or large animals and humans), burns (small or large animals and humans), sunburn (in humans, dogs and sheep), non-specific vaginitis (large animals), dermatitis (small or large animals and humans), pyoderma (small and large animals), rhabditis dermatitis (dogs and cattle), eczema nasi (dogs), exudative epidermitis (swine), saddle sores (horses), proudflesh (horses), hutchburn (rabbits), dermal lesions (small or large animals and humans), udder edema (cattle, goats and sheep), abscesses (small or large animals and humans) and bovine mastitis.Type: GrantFiled: February 6, 1998Date of Patent: April 2, 2002Assignee: Epicare Ltd.Inventor: Steven R. Schutt
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Patent number: 6348212Abstract: Blisters of the skin are treated by applying to the skin over the blister a flexible moisture-containing hydrophilic hydrogel patch that includes a backing support such as paper, cloth or plastic and a water-based hydrogel layer applied to the backing. The hydrogel layer comprises a hydrophilic natural or synthetic polymer to provide body dispersed in water and can be a tacky adhesive. The polymer can comprise any high molecular weight hydrophilic carbohydrate such as karaya, cornstarch, or a kelp gel and/or a synthetic hydrophilic polymer such as polyacrylamide or polyacrylic acid. A humectant such as a polyhydric alcohol, keeps the gel layer moist. A solute such as salt, protein, sugar or an alcohol is dissolved in the water in a quantity sufficient to raise the osmotic pressure enough to maintain the hydrogel layer in a hypertonic state with respect to the blister.Type: GrantFiled: May 18, 1999Date of Patent: February 19, 2002Assignee: LecTec CorporationInventors: Alan C. Hymes, Jane Nichols
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Patent number: 6344189Abstract: The healing of chronic wounds, such as leg ulcers, is accelerated via topical administration of a serine protease inhibitor, such as PAI-2. Wound healing also is promoted using combinations of protease inhibitors, such as PAI-2 with other serine protease inhibitors and/or with protease inhibitors such inhibitors of metalloproteinases, acid proteases, and thiol proteases, respectively.Type: GrantFiled: November 13, 1998Date of Patent: February 5, 2002Assignee: Biotech Australia Pty., Ltd.Inventors: Clive Leighton Bunn, John Lewis Andrews, Phillip John Sharp
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Patent number: 6342213Abstract: A cyanoacrylate adhesive is applied to non-suturable, non-sterile wound surfaces to protect and/or treat such surfaces, to promote wound healing and to retard infection of the wound.Type: GrantFiled: April 22, 1994Date of Patent: January 29, 2002Assignee: MedLogic Global CorporationInventors: Leonard V. Barley, Linda M. Barley, J. Royce Renfrow, Patrick J. Tighe
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Patent number: 6335088Abstract: The present invention provides a moisture-retentive cooling gel, a laminate thereof, and a moisture-retentive cooling plaster, which offer moisture-retaining and cooling effects for a controlled duration and have superior functionality, e.g., capability of delivering and transporting an effective ingredient such as a pharmacological active ingredient, a perfume or a deodorant. The moisture-retentive cooling gel comprises: a water-retentive matrix (a1) of a water-soluble polymer having a water content of not lower than 40 wt %; and fibers (f) dispersed in the water-retentive matrix, the fibers (f) having a hydrophilic property at least at surfaces thereof, some of the fibers (f) being exposed on a surface of the water-retentive matrix (a1). The gel has a higher water content and a higher water vaporization rate. An endothermally water-dissolvable compound may be retained in the water-retentive matrix and/or the fibers for enhancement of the cooling capacity of the gel.Type: GrantFiled: April 29, 1999Date of Patent: January 1, 2002Assignee: Daiya Pharmaceutical Co., Ltd.Inventors: Shinji Morikane, Daizo Morikane
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Patent number: 6335388Abstract: Prolamine-plant polar lipid compositions are provided, said compositions including a mixture of a prolamine, a plant polar lipid, at least one polyalcohol in a hydro-alcoholic solution, and an active agent, wherein the composition forms a substantially homogeneous dispersion with skin adhesive properties; wherein the dispersion forms a film and wherein the film contains a gradient of concentrations of the active agent.Type: GrantFiled: October 2, 1998Date of Patent: January 1, 2002Assignee: Lavipharm Laboratories Inc.Inventor: Spiros Fotinos
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Publication number: 20010055608Abstract: Blisters of the skin are treated by applying to the skin over the blister a flexible moisture-containing hydrophilic hydrogel patch that includes a backing support such as paper, cloth or plastic and a water-based hydrogel layer applied to the backing. The hydrogel layer comprises a hydrophilic natural or synthetic polymer to provide body dispersed in water and can be a tacky adhesive. The polymer can comprise any high molecular weight hydrophilic carbohydrate such as karaya, cornstarch, or a kelp gel and/or a synthetic hydrophilic polymer such as polyacrylamide or polyacrylic acid. A humectant such as a polyhydric alcohol, keeps the gel layer moist. A solute such as salt, protein, sugar or an alcohol is dissolved in the water in a quantity sufficient to raise the osmotic pressure enough to maintain the hydrogel layer in a hypertonic state with respect to the blister.Type: ApplicationFiled: May 18, 1999Publication date: December 27, 2001Inventors: ALAN C. HYMES, JANE NICHOLS
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Publication number: 20010055615Abstract: This invention relates generally to two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired. In particular, they are useful as tissue sealants, in promoting hemostasis, for drug delivery, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.Type: ApplicationFiled: April 16, 1999Publication date: December 27, 2001Inventors: DONALD G. WALLACE, GREGORY CRUISE, WOONZA RHEE, JACQUELINE SCHROEDER, GEORGE COKER
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Patent number: 6329413Abstract: An allantoin-containing skin cream composition can comprise allantoin and at least one anionic or nonionic emulsifier that is substantially hydrophilic and is soluble in water. The pH of the composition is in a range of from about 5.0 to about 6.5. The composition can further comprise an acidic anionic polymer. A preferred acidic anionic polymer is a carboxypolymethylene polymer. The composition can further comprise a carbohydrate polymer such as galactoarabinan, polygalactose or polyarabinose. The composition can additionally comprise other ingredients such as herbal extracts, an antioxidant component, an emollient component, a chelator, a solvent component, or a preservative component. The composition is useful as a skin protectant.Type: GrantFiled: May 12, 2000Date of Patent: December 11, 2001Assignee: Alwyn Company, Inc.Inventor: Elliott Farber
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Patent number: 6322814Abstract: A process is claimed whereby an aqueous solution of agar, in which most (ideally all) 4-linked residues consist of 3,6-anhydro-L-galactose, is subjected to partial acid hydolysis and upon neutralization following the time appropriate for the chosen conditions, a low strength gel is obtained, from which, contrary to expectations, a polyagarobiose can be obtained by freeze-thawing and straining, thereby eliminating undesirable agaroid materials without the appropriate 3,6-anhydrogalactosyl content. The appropriate time of hydrolysis depends on initial gel strength, pH, counterion concentration and temperature. As an example, agar (gel strength 700 g/cm2, made to 1.86% solution) pH 3.25, counterion citrate (360 mg/L) at 96° C. requires 25 minutes to yield a material with an eventual gel stregth (1.5% solution) of 40 g/cm2. A stabilized product can be prepared by reducing terminal anhydrogalactosyl residues with sodium borohydride.Type: GrantFiled: November 29, 1999Date of Patent: November 27, 2001Inventor: Ian James Miller
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Publication number: 20010043935Abstract: Processes for treatment of at least one condition chosen from seborrhoea of the skin and scalp, disorders associated with seborrhoea, and disorders associated with microorganisms of the genus Propionibacterium comprising applying to an area in need of said treatment at least one compound chosen from certain polyamino acid derivatives. Processes for the manufacture of a composition for treatment of at least one condition chosen from seborrhoea of the skin and scalp, disorders associated with seborrhoea, and disorders associated with microorganisms of the genus Propionibacterium, said process comprising including in said composition at least one certain polyamino acid derivative. Anti-seborrhoeic and anti-acne compositions comprising at least one certain polyamino acid derivative.Type: ApplicationFiled: January 29, 2001Publication date: November 22, 2001Inventors: Michel Philippe, Sylvie Cupferman
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Patent number: 6312725Abstract: This invention relates generally to two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired. In particular, they are useful as tissue sealants, in promoting hemostasis, for drug delivery, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.Type: GrantFiled: April 16, 1999Date of Patent: November 6, 2001Assignee: Cohesion Technologies, Inc.Inventors: Donald G. Wallace, Gregory M. Cruise, Woonza M. Rhee, Jacqueline Anne Schroeder, George T. Coker, III, Marcee M. Maroney
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Patent number: 6309631Abstract: Barrier creams are described which are useful in protecting a user from burns during exposure to heat. The creams comprise a base cream with at least one of a melt additive and a reflective additive, or ideally both a melt additive and a reflective additive. The cream preferably is waterproof and has an acceptable longevity of application.Type: GrantFiled: July 20, 2000Date of Patent: October 30, 2001Assignee: Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern IrelandInventors: Graham J Cooper, Paul M Dearden
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Patent number: 6306243Abstract: The pH-modified monomer and polymer compositions are useful as biomedical and surgical adhesives, sealants, implants and bioactive agent release carriers or matrices. They comprise a monomer or polymer; and an effective amount of an acidic or basic pH modifier effective to modify the pH of an immediate in vivo environment of the composition to a pH range at which the polymer biodegrades at a different rate than at physiologic pH. The invention also relates to in vivo applications in which surfaces are joined or treated with such pH-modified biocompatible compositions.Type: GrantFiled: June 7, 2000Date of Patent: October 23, 2001Assignee: Closure Medical CorporationInventors: Jeffrey G. Clark, Jeffrey C. Leung
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Patent number: 6306383Abstract: This invention relates to the topical treatment of keloids, hypertrophic scars and burn scars by the use of a selected protein kinase c inhibitor and an effective penetrating agent selected from lecithin organogel or poloxamer 407 lecithin organogel. The protein kinase c inhibitors may be selected from sphingosine, sphinganine, phytosphingosine, N-Acetylsphingosine, N-Hexanoylsphingosine, N-Octanoylsphingosine, curcumin, tetrahydrocurcumin, curcuminoids or apigenin.Type: GrantFiled: August 31, 2001Date of Patent: October 23, 2001Inventor: Wilson T Crandall
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Patent number: 6303112Abstract: A wound healant composition comprising a therapeutically effective amount of activated growth factors and ascorbic acid and/or at least one retinoid and/or at least one antibiotic, that facilitates the growth of new tissue.Type: GrantFiled: November 23, 1999Date of Patent: October 16, 2001Inventor: Charles E. Worden
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Patent number: 6284234Abstract: This invention relates to a method for enhancing the transmembrane penetration of benefit agents using a certain non-ionic lipid/surfactant-containing formulation as an enhancing agent, and the compositions used therein. Various active agents, such as anti-dandruff agents, hair growth agents, hair inhibitor agents, anti-acne agents, anti-aging agents, depilatory agents, and depigmentation agents, may be effectively delivered into the skin, hair follicles and sebaceous glands using the compositions of the present invention.Type: GrantFiled: July 23, 1999Date of Patent: September 4, 2001Assignee: Johnson & Johnson Consumer Companies, Inc.Inventors: Susan M. Niemiec, Jonas C. T. Wang, Stephen J. Wisniewski, Kurt S. Stenn, Gwang Wei Lu
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Patent number: 6280752Abstract: A formulation for topical use in hydrophobic gel form comprising, in weight percentages on the total weight of the formulation: 20 to 70% of vitamin E acetate, 20 to 70% of a volatile silicone chosen from the group comprising pentamer cyclomethicone tetramer cyclomethicone, hexamer cyclomethicone, hexamethyldisiloxane and mixtures thereof to 13% of hydrogenated castor oil.Type: GrantFiled: September 27, 1999Date of Patent: August 28, 2001Inventor: Giorgio Panin
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Patent number: 6270794Abstract: An absorbent wound filler having high capacity for absorbing wound exudate comprising a polymeric matrix having absorbing powders dispersed within the matrix and method of treating an exudating wound by applying the wound filler to the wound. The absorbing powders contain sodium calcium alginates and also may contain cross-linked sodium carboxymethylcellulose, absorbent polyacrylates and water soluble hydrocolloids.Type: GrantFiled: January 10, 1995Date of Patent: August 7, 2001Assignee: Bristol-Myers Squibb CompanyInventors: Rodolfo D. Cilento, Laura Lee Bolton, Louis A. Pirone
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Patent number: 6262020Abstract: There is provided a composition for healing burns and wounds in mammals which contains the combination of hyaluronic acid and a serine protease inhibitor. Advantageously, elements found in amniotic fluid are also included.Type: GrantFiled: February 15, 2000Date of Patent: July 17, 2001Assignee: Alphamed Pharmaceuticals Corp.Inventors: John Lezdey, Darren B. Lezdey
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Patent number: 6261544Abstract: A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.Type: GrantFiled: February 15, 1999Date of Patent: July 17, 2001Assignee: Focal, Inc.Inventors: Arthur J. Coury, Luis Z. Avila, Chandrashekhar P. Pathak, Shikha P. Barman
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Patent number: 6254879Abstract: The invention concerns a new pharmaceutical agent for oral or topical administration in the treatment of protozoal diseases, in particular of leishmaniasis, which contains as the active substance one or several compounds having the general formula I in which R1 is a saturated or monounsaturated or polyunsaturated hydrocarbon residue with 12 to 20 C atoms and R2, R3 and R4 denote independently of one another hydrogen, a C1-C5 alkyl group, a C3-C6 cycloalkyl group or a C1-C5 hydroxyalkyl group whereby two of the residues R2, R3 and R4 can together form a C2-C5 alkylene group which, if desired, can be substituted with an —O—, —S— or NR5 group, in which R5 is hydrogen, a C1-C5 alkyl group, a C3-C6 cycloalkyl group or a C1-C5 hydroxyalkyl group as well as, if desired the usual pharmaceutical auxiliary, diluting, carrier or/and filling substances.Type: GrantFiled: July 23, 1999Date of Patent: July 3, 2001Assignees: Max-Planck-Gessellschaft zun Förderung der Wissenschaften e.V., Asta Medica AGInventors: Hansjörg Eibl, Clemens Unger, Jürgen Engel
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Patent number: 6228379Abstract: A compound for reducing the incidence of pseudofolliculitis combines a mild skin astringent, an oil based epidermal softener, and a hair stiffener. One embodiment of the compound combines refined powdered oatmeal and emollient of the compound combines refined powdered oatmeal and emollient oil, such as mink oil and liquid vitamin A in a petroleum jelly base. The mixture is applied by being massaged into the skin prior to lathering and then again immediately after the rinsing of the face after shaving. Continual usage significantly reduces the eruption of pseudofolliculitis.Type: GrantFiled: October 19, 1999Date of Patent: May 8, 2001Inventor: John Campbell
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Patent number: 6214332Abstract: Antimicrobial cyanoacrylate compositions are applied to suturable wound surfaces to close the wound surface.Type: GrantFiled: January 12, 1998Date of Patent: April 10, 2001Assignee: MedLogic Global CorporationInventors: Ian N. Askill, Richard J. Greff, Michael M. Byram
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Patent number: 6200596Abstract: Skin treatments which do not interfere with the ability of pressure-sensitive adhesives to adhere to skin are disclosed. The treatment compositions include an acrylate polymer dissolved in an emollient oil. Use of the treatment provides a method of protecting mammalian skin without interfering with the application of medical adhesive dressings.Type: GrantFiled: January 21, 1994Date of Patent: March 13, 2001Assignee: 3M Innovative Properties CompanyInventors: Donald H. Schwartzmiller, Neil A. Randen
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Patent number: 6197325Abstract: This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, antiproliferatives, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Further provided are methods of using the site-specific supplemented tissue sealants, including preparation of a biomaterial.Type: GrantFiled: June 7, 1995Date of Patent: March 6, 2001Assignee: The American National Red CrossInventors: Martin James MacPhee, William Nash Drohan, Carlos I. Lasa, Jr., Gene Liau, Christian Haudenschild
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Patent number: RE37263Abstract: There is disclosed a method for treating dermatologic diseases caused by microbial overgrowth or inflammation, such as psoriasis, fungal infections, eczema, dandruff, acne, genital herpes lesions, and leg ulcers. There is further disclosed an antiviral lubricating composition that is effective in preventing the transmission of the HIV virus and other sexually transmitted diseases. There is also disclosed systemic and anti-inflammatory compositions and formulations and a method for reducing tissue inflammation in tissues such as the bowel, muscle, bone, tendon and joints (e.g., arthritis).Type: GrantFiled: January 22, 1997Date of Patent: July 3, 2001Assignee: Alcide CorporationInventors: Robert D. Kross, Elliott J. Siff