Ion Exchange Resin Patents (Class 424/78.1)
-
Publication number: 20100272668Abstract: The present invention is to provide an antiviral substance effective for inactivating viruses, a fiber product carrying the antiviral substance, and a fiber structure. The antiviral substance comprises a polymer containing a maleic acid component as a monomer unit in its polymer chain, and is effective against an avian influenza virus. An antiviral fiber can be produced by mixing the copolymer with cellulose and spinning the resulting mixture.Type: ApplicationFiled: February 20, 2009Publication date: October 28, 2010Applicant: Daiwabo Holdings Co., Ltd.Inventors: Miki Matsushita, Koichi Otsuki, Hiroki Takakuwa, Ryota Tsunekuni
-
Patent number: 7815898Abstract: The present invention provides medicaments useful for reducing phosphorus serum level, especially in those subjects affected from hyperphosphatemia. More specifically, the present invention relates to pharmaceutical compositions to be administered by oral route in fasting periods, in order to absorb phosphorus compounds from fluids of the enteric tract, especially from saliva.Type: GrantFiled: November 29, 2005Date of Patent: October 19, 2010Assignee: CM&D Pharma LimitedInventor: Vincenzo Savica
-
Patent number: 7811555Abstract: The present invention discloses a tri-branched copolymer comprising a hydrophobic domain, a hydrophilic domain, a biologically active moiety, and an alkyl core of 2 to 10 carbon atoms. The hydrophobic domain, the hydrophilic domain, and the biologically active moiety are separately linked to the alkyl core of 2 to 10 carbon atoms through three functional groups, wherein said three functional groups are independently the same or different. Preferably, the tri-branched copolymer is prepared through reversible addition fragmentation transfer (RAFT) polymerization and conjugation reactions. The present invention also discloses a coating composition for applying on at least a portion of one surface of an article. The coating composition comprises the inventive tri-branched copolymer. In another aspect, the present invention discloses an article having the inventive coating composition thereon. Preferably, the article is a medical device or a component of a medical device.Type: GrantFiled: December 30, 2005Date of Patent: October 12, 2010Assignee: Cordis CorporationInventor: Jonathon Z. Zhao
-
Publication number: 20100247612Abstract: A nonaqueous, extrudable composition includes at least one thermoplastic polymer in an amount of more than 20 wt % of the whole composition and tobacco. An extruded bioactive product in the form of a sheet can be made by extruding or hot melt shaping a nonaqueous composition comprising at least one thermoplastic polymer and a bioactive agent, the sheet being soluble in a user's mouth and resulting in sustained release of bioactive to the user. The sheet can be in a form that may be placed in contact with the mucosa of the user, and have an average dissolution time of 5 to 50 minutes for delivering the bioactive to the user.Type: ApplicationFiled: April 9, 2010Publication date: September 30, 2010Inventor: Richard C. Fuisz
-
Patent number: 7794698Abstract: A method of generating a change in a cellular process of a target cell is disclosed. The method comprises contacting the target cell with a solid buffer, so as to alter an intracellular pH value in at least a portion of the cell, thereby generating the change in a cellular process of a target cell of a multicellular organism. The method may be used to kill either eukaryotic or prokaryotic cells. Pharmaceutical compositions and devices are also enclosed.Type: GrantFiled: November 1, 2006Date of Patent: September 14, 2010Assignee: Oplon B.V.Inventors: Shmuel Bukshpan, Gleb Zilberstein
-
Patent number: 7776319Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.Type: GrantFiled: March 30, 2005Date of Patent: August 17, 2010Assignee: Relypsa, Inc.Inventors: Robert Alpern, Jerry Buysse, Han Ting Chang, Dominique Charmot, Michael James Cope, John Fordtran, Gerrit Klaerner, Eric Connor, Mingjun Liu, Futian Liu, Jun Shao
-
Patent number: 7749536Abstract: The present invention provides pharmaceutical compositions comprising aliphatic amine polymers such as for example Sevelamer HCl as the active pharmaceutical ingredient, wherein the aliphatica amine polymers are spray granulated. The present invention further provides methods of preparing stable pharmaceutical compositions of aliphatic amine polymers such as for example Sevelamer HCl, preferably in tablets dosage forms.Type: GrantFiled: February 14, 2006Date of Patent: July 6, 2010Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Julia Hrakovsky, Ruth Tenengauzer, Alla Ioffe, Eleonora Moin-Kotliar
-
Publication number: 20100166858Abstract: A coated drug-ion exchange resin complex comprising a core composed of a drug complexed with a pharmaceutically acceptable ion-exchange resin is provided. The drug-ion exchange resin complex is in admixture with a release retardant. The coating is a polyvinyl acetate polymer and a plasticizer. Methods of making and products containing this coated complex are described.Type: ApplicationFiled: March 12, 2010Publication date: July 1, 2010Applicant: Tris Pharma, Inc.Inventors: KETAN MEHTA, Yu-Hsing Tu
-
Publication number: 20100129308Abstract: Polymeric compounds containing polymer backbones functionalized with ion-specific recognition elements and methods for the use of these compounds are described herein. The polymeric compounds may contain multiple types of ion-specific recognition elements depending on a specific application. The polymeric compounds can be used to remove ionic species from a solution, for example, in separations applications in which a single or multiple types of ionic species are desired to be removed from the solution.Type: ApplicationFiled: November 23, 2009Publication date: May 27, 2010Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Jonathan L. Sessler, Christopher W. Bielawski, Abdullah Aydogan, Daniel J. Coady
-
Publication number: 20100111892Abstract: The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group and being a polymerization product of at least three monomers. Pharmaceutical compositions of these polymers are useful to bind potassium in the gastrointestinal tract.Type: ApplicationFiled: August 22, 2009Publication date: May 6, 2010Applicant: RELYPSA, INC.Inventors: Han-Ting Chang, Dominique Charmot, Mingjun Liu, Werner Strüver
-
Publication number: 20100111891Abstract: The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.Type: ApplicationFiled: August 22, 2009Publication date: May 6, 2010Applicant: RELYPSA, INC.Inventors: Detlef Albrecht, Michael Burdick, Han-Ting Chang, Dominique Charmot, Ramakrishnan Chidambaram, Eric Connor, Sherin Halfon, I-Zu Huang, Mingjun Liu, Jonathan Mills, Werner Strüver
-
Publication number: 20100104527Abstract: The present invention is directed to methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio.Type: ApplicationFiled: August 22, 2009Publication date: April 29, 2010Applicant: RELYPSA, INC.Inventors: Paul Mansky, Detlef Albrecht, Michael Burdick, Han-Ting Chang, Dominique Charmot, Eric Connor, Sherin Halfon, I-Zu Huang, Mingjun Liu, Werner Strüver
-
Publication number: 20100092545Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.Type: ApplicationFiled: November 9, 2009Publication date: April 15, 2010Applicant: MonoSol RX, LLCInventors: Robert K. Yang, Richard C. Fuisz, Garry L. Myers, Joseph M. Fuisz
-
Publication number: 20100074858Abstract: The invention provides a novel method for manufacturing iodinated resin particulates that have widespread utility as disinfectants. The invention also provides novel iodinated demand disinfectant iodinated resins that have superior properties than resins known in the art. The novel manufacturing process of the current invention is highly efficient and environmentally friendly and is conducted without the presence of water. Additionally, the manufacturing process produces iodinated resins that have better overall biological performance than resins produced by prior art methods owing to higher degrees of iodine in the manufactured resin particulates and higher degrees of uniformity of iodine content when comparing particulate to particulate.Type: ApplicationFiled: September 22, 2009Publication date: March 25, 2010Applicant: Triosyn Holding Inc.Inventors: Pierre J. Messier, Jean-Pierre S. Louis, David OHayon
-
Patent number: 7678369Abstract: The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.Type: GrantFiled: April 7, 2005Date of Patent: March 16, 2010Assignee: Genzyme CorporationInventors: Caroline Isabelle Bacon Kurtz, Richard Fitzpatrick
-
Patent number: 7662364Abstract: This invention reports a drug for hyperphospheremia and its preparative method. The preparation includes active constituents, lanthanum polystyrene sulfonate, and excipients. The preparative method in the invention can be summarized as follows: Polystyrene sulfonic acid is obtained by treating polystyrene sulfosalt with hydrochloric acid, soaked or eluted with water soluble lanthanum-contained solution, and washed with water till its PH is neutral. Then, the lanthanum polystyrene sulfonate solution is washed till the superfluous La? unexchanged is washed out. Lanthanum polystyrene sulfonate is taken out and crushed to powder after being dried. The lanthanum polystyrene sulfonate, whose weight percentage of lanthanum is 14-22%, is used as active constituents to prepare gastrointestinal tract preparations together with general amount of excipients with routine preparative method.Type: GrantFiled: June 26, 2006Date of Patent: February 16, 2010Inventors: Shi Biao Li, Min Qiao, Wei Sheng Zhang
-
Publication number: 20100028290Abstract: A disinfectant, especially a skin disinfectant, an antiseptic agent for open wounds and a preparation for biocidal impregnation of plants, objects or materials, especially porous objects or materials containing cellulose, plastic or textile fibres, distinguishing itself by containing 10 to 99.9 mass percent of trichloroiodic(III) resin and 0.1 to 90 mass percent of an inorganic or organic active-chlorine-containing compound.Type: ApplicationFiled: March 5, 2008Publication date: February 4, 2010Inventor: Drahomir Sokol
-
Publication number: 20090252794Abstract: The present invention provides a novel tablet with improved tablet appearance and improved swallowability. The tablet contains a pharmaceutically acceptable anion exchange resin represented by colestimide as an active ingredient, and has a visibility-resolved tablet edge.Type: ApplicationFiled: August 9, 2007Publication date: October 8, 2009Inventors: Tetsuya Suzuki, Koji Tokutomi, Tatsuo Nomura, Chika Ohno, Tetsuro Yoshinari
-
Publication number: 20090175818Abstract: Antibiotic-associated diarrhea, such as that caused by Clostridium difficile, represents a serious medical complication that can result from administering a broad-spectrum antibiotic to a subject. Such diarrhea leads to significant potassium loss from the subject. The present invention discloses a polymeric therapeutic agent that treats antibiotic-associated diarrhea and is physiologically potassium neutral. This polymer contains polystyrene sodium sulfonate and polystyrene potassium sulfonate repeat units.Type: ApplicationFiled: August 6, 2008Publication date: July 9, 2009Inventors: Caroline Bacon-Kurtz, David Davidson
-
Patent number: 7553482Abstract: The invention relates to the use of an adsorption material which has been modified with polynuclear metal oxide hydroxides for influencing the calcium level and, in particular, for treating or/and preventing atherosclerotic vascular diseases or/and disturbances of bone metabolism.Type: GrantFiled: June 12, 2002Date of Patent: June 30, 2009Assignee: Novartis International Pharmaceutical LtdInventors: Dietrich Seidel, Karl-Siegfried Boos
-
Publication number: 20090162311Abstract: Provided is a novel prophylactic and/or therapeutic agent for glomerular disease wherein a pharmaceutically acceptable anion exchange resin, typified by colestimide, is an active ingredient thereof.Type: ApplicationFiled: June 15, 2007Publication date: June 25, 2009Inventor: Masahiko Yamamori
-
Publication number: 20090148533Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.Type: ApplicationFiled: September 26, 2008Publication date: June 11, 2009Applicant: Relypsa, Inc.Inventors: Dominique Charmot, Han-Ting Chang, Eric Connor, Mingjun Liu, Gerrit Klaerner
-
Patent number: 7541024Abstract: Disclosed is a pharmaceutical composition comprising a stable polyallylamine hydrochloride polymer in which between about 4% to about 12% by weight of the polymer is a chloride anion and a pharmaceutically acceptable carrier or diluent.Type: GrantFiled: April 17, 2002Date of Patent: June 2, 2009Assignee: Genzyme CorporationInventors: John S. Petersen, Steven K. Burke, Stephen Randall Holmes-Farley
-
Publication number: 20090092573Abstract: A method of manufacturing a nicotine delivery product comprising nicotine and a cation exchange resin. More precisely, to a method for preparing a nicotine delivery product said method comprising (a) mixing nicotine, a cation exchange resin, an organic polyol and water to form a mixture wherein the total amount of water is from 26 to 45% by weight of the total mixture, and (b) removing water from the mixture to produce said nicotine delivery product.Type: ApplicationFiled: June 1, 2006Publication date: April 9, 2009Inventor: Carsten Andersen
-
Publication number: 20090016984Abstract: This invention reports a drug for hyperphospheremia and its preparative method. The preparation includes active constituents, lanthanum polystyrene sulfonate, and excipients. The preparative method in the invention can be summarized as follows: Polystyrene sulfonic acid is obtained by treating polystyrene sulfosalt with hydrochloric acid, soaked or eluted with water soluble lanthanum-contained solution, and washed with water till its PH is neutral. Then, the lanthanum polystyrene sulfonate solution is washed till the superfluous La? unexchanged is washed out. Lanthanum polystyrene sulfonate is taken out and crushed to powder after being dried. The lanthanum polystyrene sulfonate, whose weight percentage of lanthanum is 14-22%, is used as active constituents to prepare gastrointestinal tract preparations together with general amount of excipients with routine preparative method.Type: ApplicationFiled: June 26, 2006Publication date: January 15, 2009Inventors: Shi Biao Li, Min Qiao, Wei Sheng Zhang
-
Patent number: 7459151Abstract: Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.Type: GrantFiled: December 6, 2005Date of Patent: December 2, 2008Assignee: Genzyme CorporationInventors: Stephen Randall Holmes-Farley, W. Harry Mandeville, III, George M. Whitesides
-
Publication number: 20080241093Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.Type: ApplicationFiled: March 26, 2008Publication date: October 2, 2008Applicant: RELYPSA, INC.Inventors: Dominique Charmot, Han-Ting Chang, Mingjun Liu, Gerrit Klaerner
-
Publication number: 20080241092Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.Type: ApplicationFiled: March 26, 2008Publication date: October 2, 2008Applicant: RELYPSA, INC.Inventors: Dominique Charmot, Han-Ting Chang, John Fordtran, Gerrit Klaerner, Jerry M. Buysse, Robert Alpern, Mingjun Liu
-
Publication number: 20080233073Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.Type: ApplicationFiled: March 26, 2008Publication date: September 25, 2008Applicant: RELYPSA, INC.Inventors: Dominique Charmot, Han-Ting Chang, Mingjun Liu, Gerrit Klaerner
-
Publication number: 20080226579Abstract: The present invention is a novel resinate complex of (+)-clopidogrel optical isomer, wherein the (+)-clopidogrel isomer is bounded to a water-soluble cation exchange resin having sulfonic acid groups. The novel resinate complex has recognized some advantages in that (1) its chemical structure is stable, and (2) it can be formulated into a solid form that may provide taste-masking capabilities associated with bitter drugs (e.g., strong irritation, bitterness and sour taste), thus requiring no drink of water.Type: ApplicationFiled: August 24, 2006Publication date: September 18, 2008Applicant: Chong Kun Dang Pharmaceutical Corp.Inventors: Hee Jong Shin, Min Hyo Ki, Mee Hwa Choi
-
Patent number: 7399821Abstract: The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of a salt of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer salt comprises the reaction product of crosslinked polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent.Type: GrantFiled: July 24, 2006Date of Patent: July 15, 2008Assignee: Genzyme CorporationInventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley
-
Publication number: 20080044371Abstract: The present invention provides a taste-masked composition containing an active compound. The composition is taste-masked by employing a loaded polymeric matrix which is produced by incorporating or complexing the active compound on a polymeric matrix having ionic functional groups and removing unbound active compounds from the polymeric matrix.Type: ApplicationFiled: July 27, 2004Publication date: February 21, 2008Inventors: Robert D. Hargens, Yimin Jia, Greg Slominski, Suresh Vayalakkada
-
Publication number: 20070248564Abstract: This invention relates to a stable, sorbitol free suspension formulation of sodium polystyrene sulfonate.Type: ApplicationFiled: April 25, 2007Publication date: October 25, 2007Applicant: ROXANE LABORATORIES, INC.Inventors: Randall S. Wilson, Andrea M. McPhillips
-
Patent number: 7261879Abstract: The present invention relates to iodinated resins. It relates in particular to a process for preparing a polyiodide-resin wherein an anion exchange resin is contacted with a material capable of donating a member absorbable by the resin so as to convert the resin to the polyiodide-resin. The absorbable member is selected from the group consisting of I2 and polyiodide ion having a valence of ?1. In the process, conversion of the anion exchange resin to the polyiodide-resin is effected at elevated temperature and/or elevated pressure, the elevated temperature being about 100° C. or higher, the elevated pressure being greater than atmospheric pressure. The present invention also relates to a substance comprising an iodine (impregnated) resin as produced by the above process.Type: GrantFiled: September 10, 2002Date of Patent: August 28, 2007Assignee: Triosyn Holding Inc.Inventor: Pierre Jean Messier
-
Patent number: 7220406Abstract: Amine polymers, particularly aliphatic amine polymers, are useful in the treatment and prevention of bone disease and in methods for promoting bone formation. Sevelemer, polyallylamine crosslinked with epichlorohydrin, which is sold under the tradename Renagel®, is the preferred polymer used in the invention.Type: GrantFiled: October 16, 2003Date of Patent: May 22, 2007Assignee: Genzyme CorporationInventor: Steven K. Burke
-
Patent number: 7199160Abstract: Antiobestic agents and health foods containing as the active ingredient substances having an effect of adsorbing bile acid in the digestive tract, an effect of inhibiting intestinal circulation or an effect of inhibiting the absorption of exogenous lipids typified by pharmaceutically acceptable anion exchange resins. In particular, antiobestic agents and health foods characterized by lowering body weight and/or visceral fat content without reducing food intake.Type: GrantFiled: October 9, 2001Date of Patent: April 3, 2007Assignee: Mitsubishi Pharma CorporationInventors: Kazuo Suzuki, Shigekazu Nakajima, Shinji Yano
-
Patent number: 7153497Abstract: A dosage form comprising a resin/resinate combination is described. Said dosage form allows optimization of the release rate profile of active ingredients.Type: GrantFiled: March 26, 2002Date of Patent: December 26, 2006Assignee: Rohm and Haas CompanyInventors: Lyn Hughes, Simon Andrew Bellamy, Christina Hann
-
Patent number: 7147845Abstract: The present invention relates to novel antimicrobial silver ion complex resinates. More particularly, the present invention contemplates silver ion complex resinate compositions comprising a silver-thiosulfate ion complex loaded onto an organic anion exchange resin. These silver thiosulfate ion complex resinate compositions are able to release stable antimicrobial silver ion complexes when placed in a saline environment. These antimicrobial silver-ion complex resinates are useful in the treatment and prevention of infections and diseases.Type: GrantFiled: April 14, 2004Date of Patent: December 12, 2006Assignee: BioInterface Technologies, Inc.Inventor: Christopher C. Capelli
-
Patent number: 7087223Abstract: Provided in a phosphate ion adsorbent containing a weakly basic anion exchange resin as an active ingredient which aims at providing preventives and/or remedies for hyperphosphatemia having a high selectivity for the adsorption of phosphate ion and showing an effect of lowering blood phosphorus level and another effect of suppressing phosphorus excretion into the urine.Type: GrantFiled: November 9, 2004Date of Patent: August 8, 2006Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Takeshi Goto, Kazuhisa Yoshitake, Hiroshi Sorimachi, Kazuteru Moriyama
-
Patent number: 7067116Abstract: Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer, such as pullulan, and a taste masked pharmaceutically active agent, such as dextromethorphan. The taste masking agent is preferably a sulfonated polymer ion exchange resin comprising polystyrene cross-linked with divinylbenzene, such as AMBERLITE. Methods for producing the films are also disclosed.Type: GrantFiled: March 23, 2000Date of Patent: June 27, 2006Assignee: Warner-Lambert Company LLCInventors: William S. Bess, Neema Kulkarni, Suhas H. Ambike, Michael P. Ramsay
-
Patent number: 7033583Abstract: Thiol-linked polymeric prodrugs and methods of making and using the same are disclosed. The use of a sulfhydryl bond as the basic link for linking the polymer to the drug allows a prodrug to be formed which takes advantage of plasma enzymes in vivo. A preferred conjugate is Methods of preparing and treatment are also disclosed.Type: GrantFiled: November 8, 2002Date of Patent: April 25, 2006Assignee: Enzon Pharmaceuticals, Inc.Inventors: Yun H. Choe, Richard B. Greenwald
-
Patent number: 7014845Abstract: The invention relates to cross-linked copolymers based on non cross-linked polycarboxylic copolymers, said non cross-linked copolymers containing at least one polysaccharide. The invention also relates to a process for the preparation of these copolymers and their use in particular as a support in pharmaceutical compositions.Type: GrantFiled: October 3, 2000Date of Patent: March 21, 2006Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S)Inventors: Denis Labarre, Nada Lambert, Cathy Ducos, Françis Diancourt
-
Patent number: 7014846Abstract: Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.Type: GrantFiled: January 28, 2004Date of Patent: March 21, 2006Assignee: Genzyme CorporationInventors: Stephen Randall Holmes-Farley, W. Harry Manderville, III, George M. Whitesides
-
Patent number: 6992061Abstract: The invention relates to a method of removing endotoxin from preparation of alpha-1-acid glycoprotein (orosomucoid) by contact with a finely divided non-toxic resin such as fumed silica. The invention also relates to a purification process for alpha-1-acid glycoprotein which includes this depyrogenation step, and to the depyrogenated product and its clinical uses.Type: GrantFiled: February 26, 2002Date of Patent: January 31, 2006Assignee: National Blood AuthorityInventors: John Edward More, Jacqueline Rott, David Roger Lewin
-
Cosmetic preparation of active substances with a synergistically increased radical protection factor
Patent number: 6989150Abstract: The inventive cosmetic preparation of active substances, as such as well as in combination with other active substances, protects the skin against free radical aggression in a particularly effective manner. The preparation consists of a bark extract of quebracho blanco which contains at least 90 wt. % of proanthocyanidine oligomers, a silkworm extract which contains the peptide cecropine, amino acids and a vitamin mixture, a non-ionic, cationic or anionic hydro-gel, phopholipids, a yeast disintegration product and cyclodextrines. The inventive preparation can contain additional active substances such as plant extracts of acerola, sea weed, citrus, bitter orange, cherry, papaya, tea, coffee beans, skin tree and angelica. The preparations have synergistically increased radical protection factors of up to 10,000. Cosmetic compositions containing said preparations have radical protection factors of between 40 and 400 according to the portion of the preparation.Type: GrantFiled: October 8, 1999Date of Patent: January 24, 2006Assignee: COTY B.V.Inventors: Karin Golz-Berner, Leonhard Zastrow -
Patent number: 6955806Abstract: Disclosed are ionene polymers having antimicrobial activity. “Ionene polymers” as used in this invention are cationic polymers in which a substantial proportion of the atoms providing the positive charge are quaternized nitrogens located in the main polymeric chain or backbone of the polymer rather than in pendant groups. Also disclosed are antimicrobial compositions comprising ionene polymers and methods for treating microbial infections in mammals comprising the step of administering to a mammal, a therapeutically effective amount of at least one antimicrobial composition of the invention. Also disclosed are antimicrobial compositions comprising at least one ionene polymer and methods for preventing, inhibiting or eliminating the growth, dissemination, and/or the accumulation of microorganisms on a susceptible surface (including, but not limited to, the formation of biofilms on a susceptible surface) comprising the step of contacting such surface with a composition of the invention.Type: GrantFiled: January 17, 2002Date of Patent: October 18, 2005Assignee: Genzyme CorporationInventors: Richard J. Fitzpatrick, Keith K. Shackett, Jeffrey D. Klinger
-
Patent number: 6916481Abstract: The invention relates to an active substance vector multiparticulate system and to the production and use thereof. The object of the invention is an active-substance vector multiparticulate system comprising one or several active substances included in a hydrophilic organic matrix comprising at least one hydrosoluble and/or hydrodispersable anionic polymer which is insolubilized by a metallic cation. The invention can be specifically used in the food industry, detergents and agrochemistry.Type: GrantFiled: April 12, 2000Date of Patent: July 12, 2005Assignees: Aventis CropScienceInventors: Christian Prud'Homme, Etienne Fleury, Jean-Paul Michalon, Robert Zerrouk
-
Patent number: 6899868Abstract: The present invention relates to iodine demand disinfectants. It relates in particular to a process for preparing a polyiodide-resin for use as an iodine demand disinfectant wherein a porous strong base anion exchange resin in a salt form, is contacted with a material capable of donating a member absorbable by the resin so as to convert the resin to the polyiodide-resin. The adsorbable member is selected from the group comprising I2 and polyiodide ion having a valence of ?1. The process is characterized in that conversion of the anion exchange resin to the polyiodide-resin is effected at elevated temperature and elevated pressure, the elevated temperature being 100 degrees C. or higher, the elevated pressure being greater than atmospheric pressure. The present invention also relates to disinfectant substance comprising an iodine (impregnated) resin as produced by the above process.Type: GrantFiled: May 31, 2002Date of Patent: May 31, 2005Assignee: Triosyn Holding Inc.Inventor: Pierre Jean Messier
-
Patent number: 6844372Abstract: An cross-linked anion exchange resin or a salt thereof obtained by reacting a polymer (A) having amino and/or imino groups in the total number of two or more per molecule with a compound (B) having two or more functional groups capable of reacting with amino and/or imino group contained in the polymer (A). The resin or salt has a water absorption ratio of 4.0 or lower.Type: GrantFiled: March 9, 2001Date of Patent: January 18, 2005Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Takeshi Goto, Kazuhisa Yoshitake, Kazuteru Moriyama, Shuichi Toriya, Tsutomu Yuasa, Hideyuki Nishibayashi
-
Publication number: 20040241134Abstract: The present invention discloses colon cleansing compositions for treating chronic constipation. The colon cleansing compositions comprise mixtures of Calcium Polycarbophil and flaxseed powder and the mixtures are preferably in tablet form. A method for using the colon cleansing compositions for treating chronic constipation is disclosed. The preferred method is to orally masticate and swallow two tablets after each meal and two tablets before bedtime, followed by drinking a sufficient quantity of fluid to activate the colon cleansing compositions in a person's digestive system leading to colon cleansing in a period of less than 72 hours. After the initial colon cleansing, a dosage of the colon cleansing composition is preferably orally masticated and swallowed at least one of: after breakfast, after dinner, and before bedtime; followed by drinking a sufficient quantity of fluid to prevent further constipation.Type: ApplicationFiled: May 28, 2003Publication date: December 2, 2004Inventor: Mary K. Adams