Six-membered Ring Patents (Class 424/78.23)
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Patent number: 9504746Abstract: A pharmaceutical composition comprising: an active ingredient consisting of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide, salt thereof, or solvate of the foregoing; and (i) a compound, a 5% (w/w) aqueous solution or suspension of which has a pH of 8 or more, and/or (ii) silicic acid, salt thereof, or solvate of the foregoing is a highly stable pharmaceutical composition, wherein under humidified and heated storage conditions, the decomposition of said compound is sufficiently reduced, or the gelation on the surface of the pharmaceutical composition is sufficiently inhibited.Type: GrantFiled: April 25, 2013Date of Patent: November 29, 2016Assignee: Eisai R&D Management Co., Ltd.Inventors: Hisao Furitsu, Yasuyuki Suzuki
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Patent number: 8916142Abstract: The invention relates to a supramolecular polymer obtained from the reaction of (i) an amine bearing a nitrogen-containing heterocyclic group: imidazolidone, trimethyleneurea or triazine, which is capable of associating by means of hydrogen bonds and (ii) at least one fatty acid monomer comprising at least one reactive function, a dimer of identical or different fatty acids and/or a trimer of identical or different fatty acids, or a derivative of said fatty acid(s) which is selected from a fatty acid ester, and a fatty acid chloride.Type: GrantFiled: September 7, 2007Date of Patent: December 23, 2014Assignees: Arkema France, Centre National de la Recherche Scientifique (CNRS)Inventors: Sandra Grimaldi, Jean-Philippe Gillet, Manuel Hidalgo, Francois-Genes Tournilhac, Philippe Cordier, Ludwik Leibler
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Patent number: 8852640Abstract: Embodiments include a vehicle for delivery of nitric oxide comprising: a collection of micelles having an internal micelle core that comprises a polymer with N-diazeniumdiolate comprising NO complexed with secondary amines of the polymer. Embodiments include a method of making a nitric oxide vehicle comprising dissolving a polymer that comprises secondary amines in an aqueous solution and combining the polymer with nitric oxide in the solution to form a N-diazeniumdiolate comprising the nitric oxide complexed with the secondary amines, with the formation of the N-diazeniumdiolate causing the polymer to be at least partially insoluble in the solution and to form a collection of micelles that have an internal core that comprises N-diazeniumdiolate.Type: GrantFiled: July 3, 2008Date of Patent: October 7, 2014Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)Inventors: Jeffrey A. Hubbell, Yun Suk Jo, André van der Vlies
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Patent number: 8715635Abstract: A rotaxane consisting of a cucurbituril and an uncharged guest molecule, having low or null affinity therebetween is provided as well as processes for providing the same. Various uses as energy converters (“frictionless” molecular motors), biochips and biosensors using the same are also provided.Type: GrantFiled: February 6, 2008Date of Patent: May 6, 2014Assignee: Technion Research & Development Foundation LimitedInventor: Ehud Keinan
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Publication number: 20140072513Abstract: The present invention relates to degradable polyacetal polymers having a C(O)—(CH2CH2O)n—R5 or a saccharide attached to amine radical of the backbone of the polymer, their polymer-active agent conjugates and their preparation processes, to compositions, and hydrogels containing them, as well as their use in therapy, diagnostic imaging and cosmetics.Type: ApplicationFiled: April 3, 2012Publication date: March 13, 2014Inventor: Oscar Peña Gulin
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Publication number: 20130136783Abstract: A bactericidal or antimicrobial polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal or antimicrobial in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal or antimicrobial polymers, methods for rendering materials bactericidal or antimicrobial, and methods for using bactericidal or antimicrobial compositions to kill or reduce bacterial or microbial growth are also described. Applications for the inventive compositions include their use in catheters, stents, medical devices, contact lenses; root canal fillers; fibers; paper; and/or wound dressing.Type: ApplicationFiled: January 23, 2013Publication date: May 30, 2013Applicant: PURDUE RESEARCH FOUNDATIONInventor: Purdue Research Foundation
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Publication number: 20130017167Abstract: Provided herein are polymers having a therapeutic agent covalently coupled to a hydrophobic block thereof, as well as micelles and therapeutic compositions thereof.Type: ApplicationFiled: November 12, 2010Publication date: January 17, 2013Applicant: University of Washington through its Center for CommercializationInventors: Sean D. Monahan, Paul H. Johnson, Charbel Diab, Priyadarsi De, Patrick S. Stayton, Allan S. Hoffman
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Publication number: 20130011362Abstract: Provided herein are monomers incorporating folate or other targeting agent, polymers prepared therefrom, polymers prepared therefrom having a therapeutic agent covalently coupled thereto, as well as micelles and therapeutic compositions thereof.Type: ApplicationFiled: November 17, 2010Publication date: January 10, 2013Applicants: PhaseRx, Inc., University of Washington through its Center for CommercializationInventors: Sean D. Monahan, Paul H. Johnson, Michael S. DeClue, Priyadarsi De, Anna S. Gall, Patrick S. Stayton, Allan S. Hoffman, Charbel Diab
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Publication number: 20120276040Abstract: This invention relates to a process of making a group of silylated poly(N-alkyl-4-vinylpyridinium) quaternized salts suitable for use as coating materials for the treatment of substrate surfaces to impart an antimicrobial effect.Type: ApplicationFiled: July 3, 2012Publication date: November 1, 2012Inventor: Vincent T. Chuang
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Publication number: 20120195847Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.Type: ApplicationFiled: September 17, 2009Publication date: August 2, 2012Applicant: Nektar TherapeuticsInventors: Yujun Wang, Ping Zhang, Mary J. Bossard, Steven O. Roczniak
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Patent number: 8173765Abstract: A polymer having a number average molecular weight (Mn) of about 10 000 g/mol comprising a monomeric rigid moiety R and a monomeric flexible moiety F, wherein R comprises a main-chain polycyclic core and F has a main chain comprising a number of atoms sufficient for the transition temperature of the polymer to be lower than the degradation temperature of the polymer is provided. A method of manufacturing of same is also provided. Biomedical devices, scaffolds and supports for tissue engineering, delivery devices, textiles, moulds, vehicle parts, tubes, active disassembly devices, microactuators, toys and inflatable membranes comprising same are also described.Type: GrantFiled: July 30, 2008Date of Patent: May 8, 2012Assignee: Valorisation-Recherche, Limited PartnershipInventors: Xiao-Xia Zhu, Julien Gautrot, Jie Zhang, Yu Shao
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Publication number: 20110286957Abstract: Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.Type: ApplicationFiled: November 6, 2009Publication date: November 24, 2011Applicants: PHASERX, INC., UNIVERSITY OF WASHINGTONInventors: Mary G. Prieve, Paul H. Johnson, Patrick S. Stayton, Allan S. Hoffman, Robert W. Overell, Anna S. Gall, Amber E.E. Paschal, Charbel Diab, Priyadarsi De, Michael S. DeClue, Sean D. Monahan
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Publication number: 20110177020Abstract: Described is a water-borne polyurethane dispersion comprising: a. a neutralized polyurethane polymer which is the reaction product of a poly-isocyanate, a polyol, a C1-C5 diol with an organic carboxylic acid group (COOH), and a diamine, the polymer being neutralized with a component which contains at least one tertiary amine; and b. an anti-microbial compound of the formula nR—X+Y?, wherein n is 4 or 5, R-groups are C1-C100 hydrocarbyl groups which may be the same or different, X? is a positively charged ion with valency n, Y? is a negatively charged ion. Also disclosed is the method of preparing such a dispersion, a method of application of such a dispersion as a coating on surfaces of articles and articles thus coated.Type: ApplicationFiled: May 13, 2009Publication date: July 21, 2011Inventor: Hossein Mahmoud
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Publication number: 20110126767Abstract: The invention relates to a method for hatching of hatchery eggs comprising: (a) treating the egg shell surface with a coating composition comprising a coating agent, to form a coating on the surface of the egg's shell; and (b) incubating the egg under conditions to cause hatching to occur; wherein the yield of hatching of said hatchery eggs is improved as compared to control eggs not treated as defined in (a). The invention additionally relates to a composition for treating of hatchery eggs prior to incubation, wherein said composition comprising a coating agent, and wherein said composition improves the hatching yield of said hatchery eggs.Type: ApplicationFiled: January 10, 2008Publication date: June 2, 2011Applicant: NATRATEC INTERNATIONAL LTD.Inventors: Jacob Lahav, Emil Polyansky, Shaul Naschitz
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Publication number: 20100003338Abstract: Embodiments include a vehicle for delivery of nitric oxide comprising: a collection of micelles having an internal micelle core that comprises a polymer with N-diazeniumdiolate comprising NO complexed with secondary amines of the polymer. Embodiments include a method of making a nitric oxide vehicle comprising dissolving a polymer that comprises secondary amines in an aqueous solution and combining the polymer with nitric oxide in the solution to form a N-diazeniumdiolate comprising the nitric oxide complexed with the secondary amines, with the formation of the N-diazeniumdiolate causing the polymer to be at least partially insoluble in the solution and to form a collection of micelles that have an internal core that comprises N-diazeniumdiolate.Type: ApplicationFiled: July 3, 2008Publication date: January 7, 2010Inventors: Jeffrey A. Hubbell, Yun Suk Jo, Andre J. Van der Vlies
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Publication number: 20090324536Abstract: Biocidal compounds have been synthesized and tested. These biocidal compounds have broad-spectrum efficacy and their biocidal properties are easily renewable. Illustrative examples of these biocidal compounds include N-halamine monomers and polymers and silver sulfadiazine polymers. These compounds can be used to add biocidal function to various materials and articles.Type: ApplicationFiled: June 19, 2009Publication date: December 31, 2009Applicant: THE UNIVERSITY OF SOUTH DAKOTAInventors: Yuyu Sun, Zhengbing Cao
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Patent number: 7229973Abstract: Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of making poly(L-histidine), synthetic intermediates, and block copolymers are also described.Type: GrantFiled: May 19, 2003Date of Patent: June 12, 2007Inventors: You Han Bae, Kun Na, Eun Seung Lee
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Publication number: 20040253205Abstract: It was discovered that a compound represented by the general formula (I) shows strong c-Kit kinase inhibitory activity, and it inhibits proliferation of c-Kit kinase activated-cancer cells in vitro and in vivo. A novel anticancer agent showing c-Kit kinase inhibitory activity was discovered.Type: ApplicationFiled: March 10, 2004Publication date: December 16, 2004Inventors: Yuji Yamamoto, Tatsuo Watanabe, Masayuki Okada, Akihiko Tsuruoka
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Publication number: 20040109841Abstract: The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.Type: ApplicationFiled: April 7, 2003Publication date: June 10, 2004Applicant: Nektar Therapeutics AL, CorporationInventor: Xiaoming Shen
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Patent number: 6692734Abstract: The present invention relates to purified platinum complexes in which platinum is coordinated to form a single N,O- or O,O-chelate of an amidomalonate. The chelates, and pharmaceutically acceptable formulations thereof, are useful for the treatment of cancer. The platinum chelates may additionally be linked to one or more functional groups which increases water solubility and/or assists in tumor targeting of the chelate. Examples of tumor targeting moieties include polymers, in which one or more platinum chelates are attached to the polymer backbone via linkers capable of being cleaved in the body, and molecules with a high affinity for receptors which are concentrated or upregulated in tumor tissue and/or the tumor vasculature.Type: GrantFiled: January 4, 2001Date of Patent: February 17, 2004Assignee: Access Pharmaceuticals, Inc.Inventors: Donald R. Stewart, John R. Rice, John V. St. John
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Patent number: 6616941Abstract: A composition capable of forming a micelle in body fluids or in an aqueous medium and that can be injected into the body undiluted or as a diluted solution in an aqueous medium and method of preparation are disclosed. The composition comprises an amphiphilic block copolymer having a hydrophilic poly(alkyleneglycol) component and hydrophobic biodegradable polymer component, suspended in a poly (alkyleneglycol) medium. Such composition is used in the solubilization and administration of a poorly water-soluble drug.Type: GrantFiled: July 13, 2001Date of Patent: September 9, 2003Assignee: Samyang CorporationInventors: Min-Hyo Seo, In-Ja Choi
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Patent number: 6562357Abstract: A blackhead removing agent, a blackhead removing sheet and a method for producing the blackhead removing sheet are disclosed. The blackhead removing sheet comprises a base layer which is composed of a nonwoven fabric having the fineness of 0.0001 denier or more but less than 0.1 denier, and a blackhead removing layer consisting of the blackhead removing agent that contains a water-soluble macromolecular compound as a primary component. The blackhead removing agent comprises a water-soluble macromolecular compound, a filler, and a plasticizer that is compatible with the water-soluble macromolecular compound. The amount of the plasticizer in the blackhead removing agent is less than 0.01 parts by weight with respect to 100 parts by weight of the water-soluble macromolecular compound. The water-soluble macromolecular compound preferably includes a copolymer of N-vinyl-2-pyrrolidone and vinyl acetate as a primary component.Type: GrantFiled: June 7, 1999Date of Patent: May 13, 2003Assignee: Lintec CorporationInventors: Masaru Hoshi, Hideaki Okabe
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Patent number: 6534545Abstract: 6-tert-Butyl-1,1-dimethylindane derivatives which are unsaturated in the 4-position of formula: X represents: (i) either a radical of formula: (a) and Y represents a radical of formula: (b) (ii) or a radical of formula: (c) and Y represents either a radical of formula (b) or a radical of formula: Z being —O—, —S— or R1 represents —CH3, —(CH2)p—OR4, —(CH2)p—COR5 or —S(O)t—R6, p being 0, 1, 2 or 3, t being 0, 1 or 2, R2 represents H or lower alkyl, R3 represents H, lower alkyl or —COR7, R4 represents H, lower alkyl, —COR7, aryl, aralkyl, mono- or polyhydroxyalkyl, or a polyether radical, R5 represents H, lower alkyl, —OR8 or —N(r′)(r″), R6 represents H or lower alkyl, R7 represents lower alkyl, R8 represents H, alkyl, alkenyl, alkynyl, aryl, aralkyl, mono- or polyhydroxyalkyl, a sugar residuType: GrantFiled: May 26, 2000Date of Patent: March 18, 2003Assignee: Galderma Research & DevelopmentInventors: Angel De Lera, Beatriz Dominguez
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Publication number: 20030044378Abstract: Method for preparing biocidal halogenated polystyrene hydantoins. The biocidal polymers poly-1,3-dichloro-5-methyl-5-(4′-vinylphenyl)hydantoin, poly-1,3-dibromo-5-methyl-5-(4′-vinylphenyl)hydantoin, and their monohalogenated alkali metal salts and protonated derivatives have been prepared as porous beads by use of highly crosslinked polystyrene beads as starting materials. The porous beads will be useful in water and air disinfection applications when employed in cartridge filters and carafes (for water), as well as for controlling noxious odor when mixed with absorbent materials in items such as disposable diapers, incontinence pads, bandages, sanitary napkins, pantiliners, mattress covers, shoe inserts, sponges, animal litter, carpets, fabrics, and air filters or the like.Type: ApplicationFiled: September 6, 2001Publication date: March 6, 2003Applicant: Auburn UniversityInventors: Shelby D. Worley, Yongjun Chen
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Patent number: 6511949Abstract: An ophthalmic composition having regulated viscosity characterized in that it contains polyoxyethylene polyoxypropylene glycol or polyoxyethylene-polyoxypropylene-substituted ethylenediamine in association with a pharmaceutically acceptable thickener and has a viscosity ranging from 1 cps to 8 cps at 200° C., which is useful as contact lens wetting solution, eye drops, cleaning agent, and preservative for contact lenses.Type: GrantFiled: August 3, 1998Date of Patent: January 28, 2003Assignee: Rohto Pharmaceutical Co., Ltd.Inventors: Hiroo Nitta, Kaori Ogawa
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Patent number: 6491898Abstract: The invention relates to a tooth coating composition comprising (A) a polymer having one or more carboxyl or carbonyloxycarbonyl groups in its molecule, a weight average molecular weight of 10,000 to 5,000,000, a solubility of 1 g or higher in 100 g of absolute ethanol at 20° C. and a solubility of 10 g or lower in 100 g of water at 20° C., and (B) water or an alcohol having 1 to 5 carbon atoms. When coating teeth with the composition, the coating is not easily peeled by eating and drinking, but can be easily removed if necessary.Type: GrantFiled: March 20, 2000Date of Patent: December 10, 2002Assignee: Kao CorporationInventors: Atsushi Yamagishi, Yukihiro Nakano