Nitrogen Or Sulfur Containing Monomer Patents (Class 424/78.35)
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Patent number: 8449871Abstract: The present disclosure relates to novel polyurethanes comprising cationic units, of diisocyanates and of nonionic units derived from polyolefins comprising at least 10 mol % of units comprising at least one residual carbon-carbon double bond. The present disclosure also relates to cosmetic or pharmaceutical compositions comprising the polyurethanes, and also to a cosmetic treatment process, for example for shaping and/or holding the hair, comprising the application of such a composition.Type: GrantFiled: March 20, 2007Date of Patent: May 28, 2013Assignee: L'OrealInventors: Nathalie Mougin, Xavier Schultze
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Publication number: 20130129665Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: ApplicationFiled: January 11, 2013Publication date: May 23, 2013Applicant: CERULEAN PHARMA INC.Inventor: Cerulean Pharma Inc.
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Publication number: 20130115169Abstract: The present technology provides synthesized particles that mimic key structural and functional features of red blood cells. Such RBC-mimicking particles possess the ability to carry oxygen (and carbon dioxide) and flow through capillaries smaller than their own diameter. Further, such particles can also deliver drugs and imaging agents. These particles provide a new paradigm for the design of drug delivery and imaging carriers since they combine the functionality of natural RBCs with the broad applicability and versatility of synthetic drug delivery particles. Further, such particles can be used for detoxification and other biomedical applications.Type: ApplicationFiled: December 3, 2010Publication date: May 9, 2013Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Joerg Lahann, Samir Mitragotri, Srijanani Bhaskar, Nishit Doshi, Alisar A. Zahr
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Publication number: 20130101547Abstract: The present specification generally relates to compositions comprising a thermoresponsive polymer and methods of treating a soft tissue condition using such compositions.Type: ApplicationFiled: October 16, 2012Publication date: April 25, 2013Applicant: ALLERGAN, INC.Inventor: Allergan, Inc.
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Patent number: 8420067Abstract: The present invention relates generally to branched macromolecules bearing functional moieties. In particular, the invention relates to dendrimers, derived from lysine or lysine analogues, bearing a plurality of functional moieties. The invention further relates to the use of such macromolecules, particularly in therapeutic applications, and compositions comprising them.Type: GrantFiled: August 10, 2007Date of Patent: April 16, 2013Assignee: Starpharma Pty LtdInventors: Guy Yeoman Krippner, Charlotte Claire Williams, Brian Devlin Kelly, Scott Andrew Henderson, Zemin Wu, Pasquale Razzino
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Patent number: 8404224Abstract: Cationic polymers hydrolyzable to zwitterionic polymers, monomers for making the cationic polymers, surfaces that include the polymers, therapeutic agent delivery systems that include the cationic polymers, methods for administering a therapeutic agent using the delivery systems, and methods for making and using the cationic polymers, monomers, surfaces, and therapeutic agent delivery systems.Type: GrantFiled: September 14, 2012Date of Patent: March 26, 2013Assignee: University of WashingtonInventors: Shaoyi Jiang, Shengfu Chen, Zheng Zhang, Gang Cheng, Hong Xue, Louisa R. Carr
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Patent number: 8404784Abstract: A novel process of manufacturing sevelamer carbonate from a polyallylamine carbonate or bicarbonate chloride salt. Process for manufacture of carbonate and/or bicarbonate salts of water insoluble polymers containing amino groups that are useful as anion binders in the gastrointestinal (GI) system. The process arranges the polyallylamine chain in a solution in such a way that the cross-linking reaction with epichlorohydrin can be controlled at a desired reaction rate.Type: GrantFiled: December 2, 2009Date of Patent: March 26, 2013Assignee: Navinta LLCInventors: Christopher N. Jobdevairakkam, Hero Velladurai
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Patent number: 8394393Abstract: A composite material containing polymeric nanofibers, themselves containing NO-donor molecules, imbibed with an elastomer matrix is permeable to both water and gas so that dissociation reactions in the presence of water releases NO gas in a sustained manner. The NO-donor nanofibers may be formed by synthesizing acceptable NO-donor molecules, blending such molecules in solution with PVP, PCL or PVAc, electrospinning the blend at relatively high voltage for form fiber mats, applying PDMS rubber to the fiber mat and crosslinking it. The resulting NO-releasing electrospun fiber composite may be used in medical devices such as catheters, stents, or vascular grafts, with the purpose of releasing nitric oxide within a controlled rate and for a sustained period of time, as well as other known medical applications for NO.Type: GrantFiled: April 6, 2011Date of Patent: March 12, 2013Assignee: Syracuse UniversityInventors: Patrick Mather, Ifeanyi Onyejewke, Kazuki Ishida
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Publication number: 20130052156Abstract: This invention provides a method of inactivating non-enveloped virus particles. The method includes the step of contacting the virus with a virucidally-enhanced alcoholic composition that includes an alcohol, and enhancers selected from cationic oligomers and polymers, proton donors, chaotropic agents, and mixtures thereof.Type: ApplicationFiled: October 8, 2012Publication date: February 28, 2013Applicant: GOJO INDUSTRIES, INC.Inventor: GOJO Industries, Inc.
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Publication number: 20130022570Abstract: The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.Type: ApplicationFiled: February 24, 2011Publication date: January 24, 2013Applicant: RELYPSA, INC.Inventors: Jordan Kopping, Kalpesh Biyani, Eric Connor, Scott Hecker, Inez Lees, Grace Quaker, Faleh Salaymeh, Hongmin Zhang, David Bergbreiter, Paul Mansky, YongQi Mu, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao
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Publication number: 20130011364Abstract: The present invention relates to polymers imprinted by retention solutes, use of same as well as compositions containing same.Type: ApplicationFiled: March 18, 2011Publication date: January 10, 2013Inventors: Thomas Fichert, Ingo Bichlmaier
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Patent number: 8349309Abstract: A pharmaceutically-active polymeric compound of the general formula (I), Y-[Yn-LINK B-X]m-LINK B??(I) wherein (i) X is a coupled biological coupling agent of the general formula (II) Bio-LINK A-Bio??(II) wherein Bio is a biologically active agent fragment or precursor thereof linked to LINK A through a hydrolysable covalent bond; and LINK A is a coupled central flexible linear first segment of <2000 theoretical molecular weight linked to each of said Bio fragments; (ii) Y is LINK B-OLIGO; wherein (a) LINK B is a coupled second segment linking one OLIGO to another OLIGO and an OLIGO to X or precursor thereof; and (b) OLIGO is a short length of polymer segment having a molecular weight of less than 5,000 and comprising less than 100 monomeric repeating units; (iii) m is 1-40; and (iv) n is selected from 2-50. The compounds are useful as biomaterials, particularly, providing antibacterial activity in vivo.Type: GrantFiled: June 3, 2010Date of Patent: January 8, 2013Assignee: Interface Biologics Inc.Inventors: J. Paul Santerre, Mei Li
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Publication number: 20130004785Abstract: A method of preserving a cellulosic material are provided. The method includes contacting the cellulosic material with a paraben-containing monomer and polymerizing the paraben-containing monomer. Articles including a cellulosic material and at least one polymer which includes paraben moieties are also provided.Type: ApplicationFiled: May 1, 2012Publication date: January 3, 2013Inventors: William B. CARLSON, Gregory D. PHELAN
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Patent number: 8337881Abstract: A polymerizable antimicrobial formulation for forming a wound closure adhesive comprising cyanoacrylate monomer and diiodomethyl-p-tolylsulfone; and a method for closing the approximated edges of a wound with a polymeric film that substantially inhibits the growth of microorganisms, where the polymeric film is formed by use of the polymerizable antimicrobial formulation.Type: GrantFiled: August 16, 2004Date of Patent: December 25, 2012Assignee: Ethicon, Inc.Inventors: Binoy K. Bordoloi, Shubhangi R. Bhende
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Publication number: 20120321585Abstract: The present invention provides a method of manufacturing a hydrogel comprising the step of crosslinking a biopolymer using a carbodiimide crosslinker of Formula I wherein at least one of R1 and R2 is a functional group that is a bulky organic functional group. R1 and R2 can each independently be an optionally substituted saturated or unsaturated functional group selected from the group consisting of an alkyl, a cycloalkyl, a heterocyclic, and an aryl. The bulky organic functional group will slow down the crosslinking reaction of carbodiimide due to the steric effects and/or electronic effects, in comparison to a crosslinking reaction using EDC. Also provided are the hydrogels and ophthalmic devices prepared using the method of the invention and uses thereof.Type: ApplicationFiled: September 29, 2010Publication date: December 20, 2012Applicants: UNIVERSITY OF OTTAWA, OTTAWA HOSPITAL RESEARCH INSTITUTEInventors: May Griffith, Fengfu Li, Jae-Il Ahn
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Patent number: 8323633Abstract: This invention provides a method of inactivating non-enveloped virus particles. The method includes the step of contacting the virus with a virucidally-enhanced alcoholic composition that includes an alcohol, and an enhancer selected from the group consisting of cationic oligomers and polymers, proton donors, chaotropic agents, and mixtures thereof.Type: GrantFiled: February 6, 2012Date of Patent: December 4, 2012Assignee: GOJO Industries, Inc.Inventors: Marcia Snyder, David R. Macinga, James W. Arbogast
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Patent number: 8323632Abstract: The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.Type: GrantFiled: June 2, 2011Date of Patent: December 4, 2012Assignee: Nektar TherapeuticsInventors: Xuan Zhao, Zhongxu Ren, Kazunori Emoto
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Publication number: 20120288469Abstract: A solid material adapted to kill bacteria in planktonic, spore and biofilm states is lethal toward a wide spectrum of gram positive and gram negative bacteria as well as other microbes. The solid material includes a significant amount of one or more surfactants entrained in a crosslinked polymeric network.Type: ApplicationFiled: May 10, 2012Publication date: November 15, 2012Inventor: Matthew F. MYNTTI
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Publication number: 20120288470Abstract: Disclosed herein are ophthalmic cleaning systems and methods for their use, which comprise an ophthalmic solution and lens case, wherein the solution includes dual disinfectants and the lens case includes silver. When the lens case is combined with the solution according to the system of the present invention, it surprisingly exhibits synergistic activity which results in a faster antimicrobial activity.Type: ApplicationFiled: September 22, 2011Publication date: November 15, 2012Applicant: Abbott Medical Optics Inc.Inventors: Stanley W. Huth, Simon Kilvington, Simon Cheung
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Publication number: 20120251483Abstract: Provided are methods of treating cardiac infarction by using an injectable material to influence cardiac structure and remodeling after infarction. Also provided are kits that comprise an injectable material to influence cardiac structure.Type: ApplicationFiled: March 27, 2012Publication date: October 4, 2012Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Jason A. Burdick, Robert C. Gorman, Joseph H. Gorman, III, Jamie L. Ifkovits
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Publication number: 20120244105Abstract: A pharmaceutical composition comprising a polymeric binder including a high molecular weight synthetic polymer having a backbone constituted of non hydrolysable covalent bonds, said polymer being able to form electrostatic bonds at a pH lower than the isoelectric point of gluten and peptides derived from the degradation of gluten, and being able to bind to gluten or peptides derived from the degradation of gluten in the gastrointestinal tract, and a pharmaceutically acceptable carrier. Methods of using the polymeric binder for binding gluten or a peptide derived from the degradation of gluten, for decreasing the degradation of gluten into toxic peptides or for decreasing interaction of gluten or peptides derived from the degradation of gluten with the gastrointestinal mucosa.Type: ApplicationFiled: May 1, 2012Publication date: September 27, 2012Applicant: VALORISATION-RECHERCHE LIMITED PARTNERSHIPInventors: Jean-Christophe Leroux, Mohamad Nasser Eddine
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Patent number: 8268301Abstract: Cationic polymers hydrolyzable to zwitterionic polymers, monomers for making the cationic polymers, surfaces that include the polymers, therapeutic agent delivery systems that include the cationic polymers, methods for administering a therapeutic agent using the delivery systems, and methods for making and using the cationic polymers, monomers, surfaces, and therapeutic agent delivery systems.Type: GrantFiled: November 19, 2008Date of Patent: September 18, 2012Assignee: University of WashingtonInventors: Shaoyi Jiang, Shengfu Chen, Zheng Zhang, Gang Cheng, Hong Xue, Louisa R. Carr
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Publication number: 20120201779Abstract: A method of and product for reducing the undesirable effects of allergic rhinitis by applying a formulation to a person's nasal region or nostrils. The formulation creates a barrier that prevents airborne allergens from contacting nasal mucous membranes, and at the same time, electrostatically repels or attracts and captures the particulate allergens, and changes their shapes so as to mitigate the effects of allergic rhinitis. The formulation may be made more effective by the addition of an anti-histamine compound.Type: ApplicationFiled: April 13, 2012Publication date: August 9, 2012Applicant: TRUTEK CORPORATIONInventor: Ashok Wahi
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Patent number: 8216561Abstract: The present invention relates to a bio-stable hydrogel for use in the treatment and prevention of incontinence and vesicouretal reflux. The hydrogel is obtainable by combining acrylamide and methylene bis-acrylamide in amounts to provide about 0.5 to 25% by weight polyacrylamide, based on the total weight of the hydrogel.Type: GrantFiled: August 31, 2006Date of Patent: July 10, 2012Assignee: Contura A/SInventor: Jens Petersen
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Publication number: 20120171155Abstract: The present invention relates to compositions having durable antimicrobial activity. The compositions include a carbonate/bicarbonate salt of a quaternary ammonium cation, an organic acid, hydrogen peroxide and a polymer. The polymer is selected from cationic amine polymer-epichlorohydrin adduct, cationic amine polymer-epichlorohydrin resin, poly(methacrylamidopropyltrimethylammonium)chloride, poly(bis(2-chloroethyl)ether-alt-1,3-bis(dimethylamino)propyl)urea, poly(diallyldimethylammonium)chloride, poly(t-butyl acrylate co-ethyl acrylate co-methacrylic acid), polyethylene oxide, polyquaternium-16, polyquaternium-22, polyquaternium-67 and mixtures thereof.Type: ApplicationFiled: December 30, 2010Publication date: July 5, 2012Inventors: Corey T. Cunningham, Rebecca Ann Vongsa, Stacy A. Mundschau, David W. Koenig, Douglas R. Hoffman
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Publication number: 20120164210Abstract: The present invention relates to a cancer-cell-specific polymer compound containing a photosensitizer for photodynamic therapy and having a surface to which an antibody against a cancer-cell-specific antigen binds. An object of the present invention is to provide a photodynamic therapeutic agent that can reach the cancer tissue at a low concentration via active targeting and makes complications (e.g., sunlight hypersensitivity) associated with photodynamic therapy unlikely to occur.Type: ApplicationFiled: December 17, 2009Publication date: June 28, 2012Inventors: Masakazu Ueda, Kayoko Ueda, Tsunenori Arai, Sachiko Matsuda, Kazuhiko Ishihara
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Patent number: 8202962Abstract: Processes for making polyesters in a polyester production facility are disclosed, that include the steps of: forming a reaction medium comprising at least one monomer that includes terephthalic acid (TPA) and/or an ester derivative of TPA; subjecting at least a portion of the reaction medium to one or more chemical reactions in the polyester production facility to thereby produce the polyester; heating at least a portion of the reaction medium via indirect heat exchange with high-pressure steam, wherein the heating causes at least a portion of the high-pressure steam to condense and thereby provide pressurized condensed water; flashing at least a portion of the pressurized condensed water to thereby produce lower-pressure steam; and heating one or more process fluid streams of the polyester production facility via indirect heat exchange with at least a portion of the lower-pressure steam, wherein the process fluid streams include any stream that is formed predominately of the reaction medium and/or the at leaType: GrantFiled: September 11, 2009Date of Patent: June 19, 2012Assignee: Grupo Petrotemex, S.A. de C.V.Inventors: Alan George Wonders, James Donald Simpson, Bruce Roger DeBruin
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Publication number: 20120148522Abstract: An article comprising a polyelectrolyte complex comprising an interpenetrating network of at least one predominantly positively charged polyelectrolyte polymer and at least one predominantly negatively charged polyelectrolyte polymer, the polyelectrolyte complex further comprising a plurality of closed-shell pores, the plurality of pores having at least one average transverse dimension between about 100 nanometer and about 1000 micrometers.Type: ApplicationFiled: August 19, 2010Publication date: June 14, 2012Applicant: FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventor: Joseph B. Schlenoff
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Patent number: 8198397Abstract: Integrated processes for making polyesters are disclosed, that include the steps of: (a) producing an aromatic polycarboxylic acid in a monomer production facility; (b) producing a polyester in a polyester production facility, wherein the producing of the polyester comprises the substeps of: (i) forming a polyester reaction medium comprising at least a portion of the aromatic polycarboxylic acid from the monomer production facility, (ii) subjecting at least a portion of the polyester reaction medium to one or more chemical reactions to thereby produce the polyester, (iii) heating the polyester reaction medium at one or more locations in the polyester production facility via indirect heat exchange with high-pressure steam, wherein the heating causes at least a portion of the high-pressure steam to condense and thereby provide pressurized condensed water, and (iv) flashing at least a portion of the pressurized condensed water to thereby produce lower-pressure steam; and (c) using at least a portion of the lowerType: GrantFiled: September 11, 2009Date of Patent: June 12, 2012Assignee: Grupo Petrotemex, S.A. de C.V.Inventors: Alan George Wonders, James Donald Simpson, Bruce Roger DeBruin
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Patent number: 8197856Abstract: A kit for promoting hair growth on areas of the scalp that has been affected by fungal infections. The kit reduces the loss of hair, gradually destroys the cause of the loss of hair, and eventually restores the normal hair growth in the areas of the scalp affected by the fungi. The kit is comprised of a first powdered mixture and three liquid compositions. The elements of the kit are applied to the scalp of an individual experiencing hair loss due to fungi.Type: GrantFiled: August 14, 2008Date of Patent: June 12, 2012Inventor: Felix Cruz
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Patent number: 8197847Abstract: The application discloses a process for making a polymer having pendant side groups comprising: (i) polymerising an olefinically unsaturated monomer functionalized with (a) an azide group optionally protected by a protecting group, or (b) an alkyne group optionally protected by a protecting group, by living radical polymerization, most preferably RAFT, transitional metal mediated living radical polymerization (TMM-LRP) and/or atom transfer radical polymerization, to produce a polymer intermediate; (ii) removing, when present, at least a portion of the total number of protecting groups from the polymer intermediate; (iii) reacting the polymer intermediate with at least one pendant side group moiety functionalised with (a) an alkyne group or (b) an azide group respectively so that the alkyne and azide groups react to attach the pendant side group to the polymer. Processes for making supports comprising pendant side groups, and polymers and supports prepared by the method are also disclosed.Type: GrantFiled: September 5, 2008Date of Patent: June 12, 2012Assignee: Warwick Effect Polymers Ltd.Inventors: David M. Haddleton, Guiseppe Mantovani, Vincent Ladmiral
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Patent number: 8192485Abstract: The present invention relates to reversible hydrogel systems for medical applications. Particularly, the hydrogel of the present invention is made up of copolymers that can be a hydrogel when in an oxidized state and can be a solution when in a reduced state. A solution of the copolymer can be oxidized to form a hydrogel; and the hydrogel can be reduced to form a solution of the copolymer. The solution can be dehydrated to produce the dry copolymer for storage. Furthermore, the present invention also relates to methods of making and using the reversible hydrogel systems.Type: GrantFiled: November 13, 2003Date of Patent: June 5, 2012Assignees: The United States of America, as represented by the Department of Veterens Affairs, The Washington University in St. LouisInventor: Nathan Ravi
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Publication number: 20120134952Abstract: This invention provides a method of inactivating non-enveloped virus particles. The method includes the step of contacting the virus with a virucidally-enhanced alcoholic composition that includes an alcohol, and an enhancer selected from the group consisting of cationic oligomers and polymers, proton donors, chaotropic agents, and mixtures thereof.Type: ApplicationFiled: February 6, 2012Publication date: May 31, 2012Inventors: Marcia Snyder, David R. Macinga, James W. Arbogast
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Patent number: 8187634Abstract: Disclosed herein is an improved process for preparation of Sevelamer hydrochloride having phosphate binding capacity of 4.7 to 6.4 mmol/g. Further, the invention discloses Sevelamer hydrochloride compositions and a novel process for preparation of said compositions comprising high shear non-aqueous granulation.Type: GrantFiled: August 31, 2007Date of Patent: May 29, 2012Assignee: USV, Ltd.Inventors: Deepak Anant Hegde, Varsha Shashank Choudhary, Venkatasubramanian Radhakrishnan Tarur, Dhananjay Govind Sathe, Harish Kashinath Mondkar, Samadhan Daulat Patil, Sasikumar Mohan Thoovara, Yogesh Sharad Bhide
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Publication number: 20120121532Abstract: Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a first component comprising a dry preparation of a coagulation inducing agent, b) providing a second component comprising a dry preparation of a biocompatible polymer suitable for use in hemostasis, c) providing said first component and said second component in a combined form in a final container, c1) either by filling said first component and said second component into said final container so as to obtain a dry mixture in said final container, c2) or by providing said first component or said second component in said final container and adding said second component or said first component so as to obtain a combination of said first component with said second component in said final container, d) finishing the final container to. a storable pharmaceutical device containing said first component and said second component in a combined form as a dry and stable hemostatic composition.Type: ApplicationFiled: June 1, 2011Publication date: May 17, 2012Applicants: Baxter Healthcare S.A., Baxter International Inc.Inventors: Andreas Goessl, Atsushi Edward Osawa, Cary J. Reich
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Patent number: 8178079Abstract: The invention relates to novel ethylene copolymers comprising 10-60% polyethylenglycol (meth)acrylate monomers and 40-90% substantially cationic monomer. Compositions, in particular cosmetic or pharmaceutical compositions, containing the inventive copolymers and a cosmetic treatment method using said copolymers are also disclosed.Type: GrantFiled: July 1, 2005Date of Patent: May 15, 2012Assignee: L'Oreal S.A.Inventors: Nathalie Mougin, Gwenaëlle Jegou
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Publication number: 20120109044Abstract: A method for direct therapeutic treatment of myocardial tissue in a localized region of a heart having a pathological condition. The method includes identifying a target region of the myocardium and applying material directly and substantially only to at least a portion of the myocardial tissue of the target region. The material applied results in a physically modification the mechanical properties, including stiffness, of said tissue. Various devices and modes of practicing the method are disclosed for stiffening, restraining and constraining myocardial tissue for the treatment of conditions including myocardial infarction or mitral valve regurgitation.Type: ApplicationFiled: May 26, 2011Publication date: May 3, 2012Applicant: CORMEND TECHNOLOGIES, LLCInventors: William P. Santamore, Jeanne M. Lesniak
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Patent number: 8142804Abstract: A sheet for pest control, wherein said sheet is of polymeric material and comprises at least two layers; a top layer and a bottom layer, wherein the bottom layer contains a herbicide and one or more pesticides selected from among fungicides and insecticides, and the top layer optionally containing an insecticide and/or fungicide. Other aspects of the invention include a polymeric composition used in the preparation of the sheets and a method for pest control in agriculture, horticulture and gardens.Type: GrantFiled: May 29, 2008Date of Patent: March 27, 2012Assignee: Makhteshim Chemical Works Ltd.Inventor: Avner Barazani
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Publication number: 20120034169Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.Type: ApplicationFiled: June 9, 2011Publication date: February 9, 2012Applicant: The University of North Carolina at Chapel HillInventors: Mark H. Schoenfisch, Jae Ho Shin, Nathan Stasko
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Publication number: 20120009242Abstract: The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of inducing blood coagulation and delivering therapeutics for hemostatic or wound care applications, and a method of forming such a primary amine containing polymer hydrogel capable of inducing the blood coagulation process. The primary amine containing polymer hydrogel is able to achieve the same end result as biological-based hemostatics, without the innate risk of disease transmission or immunological response, and at a fraction of the price. Furthermore, due to its inherent hydrogel-based design the material has the capability of arresting blood loss while simultaneously delivering therapeutics in a controlled manner, potentially revolutionizing the way in which wounds are treated.Type: ApplicationFiled: November 3, 2009Publication date: January 12, 2012Applicants: UNIVERSITY OF MARYLAND, COLLEGE PARK, UNIVERSITY OF MARYLAND, BALTIMOREInventors: Brendan J. Casey, Peter Kofinas, Adam Behrens, Trevor A. Snyder, Bartley P. Griffith
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Patent number: 8093343Abstract: The invention described herein provides for novel nitric oxide-releasing polymers that comprise at least two adjacent units derived from acrylonitrile monomer units and containing at least one carbon-bound diazeniumdiolate. The diazeniumdiolated acrylonitrile-derived polymers can be used in medical devices therapeutically. Accordingly, the invention also provides a method of treating a biological disorder and a method of promoting angiogenesis that includes administering a medical device comprising a nitric oxide-releasing polymer comprising at least two adjacent units of acrylonitrile before exposure to nitric oxide and at least one nitric oxide releasing N2O2? group, wherein the N2O2? group is attached directly to the polyacrylonitrile backbone, to a specific location on or within the mammal in an amount effective to treat the biological disorder or promote angiogenesis.Type: GrantFiled: May 19, 2011Date of Patent: January 10, 2012Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Joseph A. Hrabie, Frank DeRosa, Larry K. Keefer
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Publication number: 20110318298Abstract: Methods for administering a polyalkyleneimine to treat or prevent a viral infection, inactivate a virus, inhibit viral adsorption to a cell, and inhibit viral invasion of a cell are presented.Type: ApplicationFiled: October 13, 2009Publication date: December 29, 2011Applicant: Nippon Shokubai Co., Ltd.Inventors: Kyoko Hayashi, Yoshie Maitani, Hiroaki Hasegawa, Takashi Kai
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Publication number: 20110262546Abstract: It is described a gold nanoparticle coated with from two to five layers of a combination of a polyelectrolyte having amino functionality and a polyelectrolyte having sulfonic functionality, or with one single layer of said polyelectrolyte having amino functionality, preferably polyallylamine, or sulfonic functionality, preferably polystyrenesulfonic, characterized in that said nanoparticle comprises an outer layer of albumin. It is also described the process for its preparation, its use as carriers intended to cross blood-brain barrier and its use as medicament, in particular for treatment of neurodegenerative diseases, more in particular of diseases caused by protein aggregates, such as prion diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis. Also described are pharmaceutical compositions comprising said nanoparticle.Type: ApplicationFiled: November 5, 2009Publication date: October 27, 2011Inventors: Giuseppe Antonio Legname, Silke Krol, Maria Fernanda Costa De Sousa
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Publication number: 20110256187Abstract: The present invention relates to coating compositions for modulating biofilm growth on a surface, the composition comprising the reaction product of: A) an ethylenically unsaturated compound, having at least one group with the following structure: and B) an ethylenically unsaturated compound.Type: ApplicationFiled: November 13, 2009Publication date: October 20, 2011Applicant: BAYER MATERIALSCIENCE LLCInventors: Edwin R. Hortelano, Paul J. Nowatzki
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Publication number: 20110244001Abstract: A composite material containing polymeric nanofibers, themselves containing NO-donor molecules, imbibed with an elastomer matrix is permeable to both water and gas so that dissociation reactions in the presence of water releases NO gas in a sustained manner. The NO-donor nanofibers may be formed by synthesizing acceptable NO-donor molecules, blending such molecules in solution with PVP, PCL or PVAc, electrospinning the blend at relatively high voltage for form fiber mats, applying PDMS rubber to the fiber mat and crosslinking it. The resulting NO-releasing electrospun fiber composite may be used in medical devices such as catheters, stents, or vascular grafts, with the purpose of releasing nitric oxide within a controlled rate and for a sustained period of time, as well as other known medical applications for NO.Type: ApplicationFiled: April 6, 2011Publication date: October 6, 2011Applicant: Syracuse UniversityInventors: Patrick Mather, Ifeanyi Onyejewke, Kazuki Ishida
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Publication number: 20110212178Abstract: Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.Type: ApplicationFiled: September 24, 2010Publication date: September 1, 2011Inventors: Michael J. Constant, Gregory M. Cruise, E. Michael Keeley, Alejandro Berenstein
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Publication number: 20110159087Abstract: Disclosed herein are pharmaceutical compositions comprising wet granulated bile acid sequestrants having the general Formula I shown, and their process of preparation. The present invention also discloses process for preparation of Colesevelam hydrochloride, an antilipemic agent.Type: ApplicationFiled: September 2, 2009Publication date: June 30, 2011Inventors: Dhananjay Govind Sathe, Harish Kashinath Mondkar, Mantripragada Narayan Rao, Samadhan Daulat Patil, Tanaji Shamrao Jadhav, Ashok Omray, Varsha Shashank Choudhary, Yogesh Sharad Bhide
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Patent number: 7968113Abstract: A method is provided to treat skin to restore barrier homeostasis and to promote normal stratum corneum function by applying to the skin a liquid composition which forms a phase inversion membrane. The amount of solids in the liquid composition is varied so as to provide a desired degree of porosity to the resulting membrane.Type: GrantFiled: January 30, 2008Date of Patent: June 28, 2011Assignee: Biomedical Development Corp.Inventor: Gregg Siegel
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Patent number: 7968664Abstract: The invention described herein provides for novel nitric oxide-releasing polymers that comprise at least two adjacent units derived from acrylonitrile monomer units and containing at least one carbon-bound diazeniumdiolate. The diazeniumdiolated acrylonitrile-derived polymers can be used in medical devices therapeutically. Accordingly, the invention also provides a method of treating a biological disorder and a method of promoting angiogenesis that includes administering a medical device comprising a nitric oxide-releasing polymer comprising at least two adjacent units of acrylonitrile before exposure to nitric oxide and at least one nitric oxide releasing N2O2— group, wherein the N2O2— group is attached directly to the polyacrylonitrile backbone, to a specific location on or within the mammal in an amount effective to treat the biological disorder or promote angiogenesis.Type: GrantFiled: September 27, 2005Date of Patent: June 28, 2011Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Joseph A. Hrabie, Michael L. Citro, Frank DeRosa, Larry K. Keefer
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Patent number: 7964182Abstract: The present invention discloses pharmaceutical composition comprising phosphate binding polymers such as Sevelamer carbonate substantially free of monovalent anion other than bicarbonate anion. Particularly, monovalent anion content is less than about 0.05% (w/w). Disclosed are compositions comprising wet granulated Sevelamer carbonate free of added metal ions and/or added monovalent anion source.Type: GrantFiled: December 1, 2010Date of Patent: June 21, 2011Assignee: USV, LtdInventors: Ashok Omray, Varsha Shashank Choudhary, Yogesh Sharad Bhide