Monomer Contains Oxygen Patents (Class 424/78.37)
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Patent number: 8568753Abstract: A microbicidal delivery system including: a microbicidal composition including a microbicidal compound including a dendrimer including one or more surface groups of formula (IV); a microbicidally active derivative thereof, or pharmaceutically acceptable salt or solvate thereof; and a carrier, excipient or diluent therefor; and a prophylactic device; the microbicidal composition being carried on a surface of the prophylactic device and being compatible therewith.Type: GrantFiled: February 1, 2006Date of Patent: October 29, 2013Assignee: Starpharma Pty LimitedInventors: Owen Timothy Grogan, Thomas David McCarthy
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Patent number: 8562966Abstract: Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.Type: GrantFiled: December 6, 2011Date of Patent: October 22, 2013Assignee: Massachusetts Institute of TechnologyInventors: Gregory T. Zugates, Andreas Zumbuehl, Robert S. Langer, Daniel Griffith Anderson
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Patent number: 8562965Abstract: The invention provides a polymer comprising (i) a first water-soluble polymer segment that is covalently attached, either directly or through one or more atoms, to a first oxygen atom that is covalently attached to a linking carbon atom; (ii) a second water-soluble polymer segment is covalently attached, either directly or through one or more atoms, to a second oxygen atom that is covalently attached to the linking carbon atom; and (iii) a reactive group that is covalently attached, either directly or through one or more atoms, to the linking carbon atom. The invention also provides, among other things, methods for preparing polymers, conjugates, pharmaceutical compositions and the like.Type: GrantFiled: May 3, 2005Date of Patent: October 22, 2013Assignee: Nektar TherapeuticsInventors: Samuel P. McManus, Antoni Kozlowski
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Publication number: 20130272996Abstract: The subject invention provides for methods of reducing the relapse rate and/or reducing the accumulation of physical disability in a relapsing-remitting multiple sclerosis human patient, the method comprising orally administering to the patient a daily dose of 0.6 mg laquinimod. The subject invention also provides for pharmaceutical oral unit dosage forms of 0.6 mg laquinimod for use in reducing the relapse rate and/or for use in reducing the accumulation of physical disability in a relapsing-remitting multiple sclerosis human patient.Type: ApplicationFiled: December 12, 2012Publication date: October 17, 2013Applicant: Teva Pharmaceutical Industries, Ltd.Inventor: Teva Pharmaceutical Industries, Ltd.
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Patent number: 8557231Abstract: Poly(?-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.Type: GrantFiled: April 6, 2005Date of Patent: October 15, 2013Assignee: Massachusetts Institute of TechnologyInventors: Robert S. Langer, David M. Lynn, David Putnam, Mansoor M. Amiji, Daniel G. Anderson
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Publication number: 20130266620Abstract: The present invention aims to provide a medical material which is safe for the live body, has high biocompatibility and is useful for promotion of cell differentiation. The present invention produces a medical material for promoting cell differentiation, which contains polyamino acid as a main component, wherein the polyamino acid contains at least one kind of amino acid residue selected from the group consisting of an alanine residue, a valine residue, a leucine residue, an isoleucine residue, a phenylalanine residue, a glycine residue, a glutamine residue, an aspartic acid residue optionally containing a protecting group in the side chain, a tyrosine residue optionally containing a protecting group in the side chain, a tryptophan residue optionally containing a protecting group in the side chain, a lysine residue optionally containing a protecting group in the side chain, and a glutamic acid residue optionally containing a protecting group in the side chain.Type: ApplicationFiled: June 6, 2013Publication date: October 10, 2013Inventors: Manabu Kitazawa, Satoru Ohashi, Yoko Masuzawa, Kousaku Ohkawa, Yasuhiko Tabata
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Publication number: 20130266533Abstract: Sulfone-containing copolymers and copolymer networks and compositions including sulfone-containing copolymers and copolymer networks may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, sulfone-containing copolymers and copolymer networks may be derived from a multi-amine-monomer and a multifunctional sulfonyl-containing monomer comprising two or more amine-reactive groups.Type: ApplicationFiled: January 28, 2013Publication date: October 10, 2013Inventors: Pradeep DHAL, Stephen Randall HOLMES-FARLEY, Chad HUVAL, Steven C. POLOMOSCANIK
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Publication number: 20130251667Abstract: Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.Type: ApplicationFiled: March 22, 2013Publication date: September 26, 2013Applicant: SANOFIInventors: Pradeep K. DHAL, David J. HARRIS, Stephen Randall HOLMES-FARLEY, Chad C. HUVAL, Vitaly NIVOROZHKIN, Bruce SHUTTS
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Patent number: 8535655Abstract: The invention relates to a biodegradable polymer comprising a plurality of releasable bioactive moieties, the releasable bioactive moieties being pendant from and covalently bonded to the biodegradable polymer backbone, wherein the biodegradable polymer backbone is formed from monomeric units that are each coupled via a biodegradable moiety, and wherein the bioactive moieties are capable of being released at a rate equal to or faster than the rate of biodegradation of the polymer backbone.Type: GrantFiled: April 8, 2011Date of Patent: September 17, 2013Assignee: Polyactiva Pty Ltd.Inventors: Michael Shane O'Shea, Florian Hans Maximilian Graichen, Russell John Tait, Heng Chy Taing, Justine Leigh Jeffery
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Patent number: 8535656Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.Type: GrantFiled: March 9, 2012Date of Patent: September 17, 2013Assignee: Board of Regents of the University of NebraskaInventors: Alexander V. Kabanov, Xiang Yi, Sarguel V. Vinogradov, William A. Banks
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Patent number: 8524216Abstract: The present invention provided a polymer and a method for preparing the polymer, wherein the polymer was a terpolymer having a molecular weight of more than 1000, and copolymerized by acrolein, acrylic acid, and low alkene-alkyl dibasic acid or low-alkene-alkyl polybasic acid.Type: GrantFiled: June 22, 2009Date of Patent: September 3, 2013Assignee: Qingdao Continent Pharmaceutical Co., Ltd.Inventors: Shengzhang Yin, Qiaoleng Wang, Zhiyong Zhang
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Patent number: 8512757Abstract: The invention provides a block copolymer comprising at least a first block and a second block. The first block comprises a plurality of temperature-sensitive monomeric units, a plurality of hydrophilic monomeric units and a plurality of targeting monomeric units, and the second block comprises a plurality of hydrophobic monomeric units. The second block comprises at least one pH-sensitive moiety.Type: GrantFiled: July 5, 2006Date of Patent: August 20, 2013Assignee: Agency for Science, Techology and ResearchInventors: Yi-Yan Yang, Shao-Qiong Liu
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Patent number: 8512722Abstract: The disclosure provides methods and materials suitable for preparing coating layers on substrates. The coatings comprise quaternary amine groups and therefore impart anti-bacterial properties to the substrate. In one embodiment, for example, there is provided a quaternary amine-containing polymeric coating comprising propylene and ethylene repeat units.Type: GrantFiled: July 23, 2010Date of Patent: August 20, 2013Assignees: California Institute of Technology, University of Southern CaliforniaInventors: Choon Woo Lee, Robert H. Grubbs, Mark Humayun
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Publication number: 20130209391Abstract: The invention relates to functionalized polymers including homopolymers and copolymers and their uses in industrial applications and in agricultural applications. In particular, the homopolymers and copolymers may be, for example, used in polymer blends, used as nutritives and in feed compositions, and used in combination with a pharmaceutical or nutritive.Type: ApplicationFiled: February 8, 2013Publication date: August 15, 2013Applicant: NOVUS INTERNATIONAL INC.Inventor: Novus International Inc.
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Publication number: 20130202551Abstract: An ionic compound capable of providing a cured material having superior antibacterial property and oxygen permeability, and a composition containing the ionic compound, and a cured material, a hydro gel and an ophthalmic lens which have long-term sustainable antibacterial property and superior oxygen permeability. The ionic compound is represented by the following formula (1): In formula (1), P represents a polymerizable functional group. Q+ represents a cationic group: Z represents an n-valent siloxanyl group in which the total atomic weight of a group of constituent atoms is no less than 70 and no greater than 1,000; Xm? represents an m-valent anion; and n is an integer of 1 to 10, where provided that n is no less than 2, a plurality of P3 and Q+3 are each independently as defined above.Type: ApplicationFiled: June 14, 2010Publication date: August 8, 2013Inventors: Kohsuke Satake, Susumu Ogawa
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Publication number: 20130195793Abstract: The present invention relates to radiation-curable antimicrobial coatings, to a process for preparation thereof, and to the use thereof.Type: ApplicationFiled: January 25, 2013Publication date: August 1, 2013Inventors: Reinhold SCHWALM, Rupert Konradi, Christina Haaf, Herbert Platsch, Catharina Hippius
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Publication number: 20130195753Abstract: One aspect of the present invention relates to methods of embolizing a vascular site in a mammal comprising introducing into the vasculature of a mammal a composition comprising an inverse thermosensitive polymer, wherein said inverse thermosensitive polymer gels in said vasculature, which composition may be injected through a small catheter, and which compositions gel at or below body temperature. In certain embodiments of the methods of embolization, said composition further comprises a marker molecule, such as a dye, radiopaque, or an MRI-visible compound.Type: ApplicationFiled: March 11, 2013Publication date: August 1, 2013Applicant: GENZYME CORPORATIONInventor: GENZYME CORPORATION
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Patent number: 8496920Abstract: Novel acrylamide and methacrylamide hydantoin monomers which can be reacted with other acrylamide, methacrylamide, acrylate, and methacrylate monomers to form copolymers, which upon halogenation, provide oxidative coatings which are biocidal for use with various materials including, but not limited to, textiles, filters, and latex paints.Type: GrantFiled: October 11, 2011Date of Patent: July 30, 2013Assignee: Auburn UniversityInventors: Shelby D. Worley, Royall M. Broughton, Hasan B. Kocer, Idris Cerkez
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Publication number: 20130189221Abstract: Method of forming tissue adhesives by reacting an oxidized polysaccharide with a water-dispersible multi-arm polyether amine, wherein at least three of the arms are terminated by primary amine groups, are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described.Type: ApplicationFiled: March 8, 2013Publication date: July 25, 2013Applicant: Actamax Surgical Materials, LLCInventor: Actamax Surgical Materials, LLC
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Publication number: 20130171093Abstract: A wound healing powder, comprising a sugar selected from the group consisting of one or more pharmaceutically acceptable monosaccharides and disaccharides, in an amount of at least 25% by weight of the powder mixture; and an absorbent agent which forms a bioabsorbable biocompatible matrix with wound secretions, comprising a polymer formed of one or more of saccharide or saccharide derivative monomers and lactic acid monomers, in an amount of at least 25% by weight of the powder mixture.Type: ApplicationFiled: August 28, 2012Publication date: July 4, 2013Inventor: Philip A. Marraccini
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Patent number: 8475779Abstract: The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.Type: GrantFiled: December 14, 2009Date of Patent: July 2, 2013Assignee: Ares Trading SAInventors: James Rasmussen, Jianxin Zhang, Sam Baldwin, Eric Zanelli, Bei Yu, Dustan Bonnin, Keith Johnson
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Publication number: 20130164250Abstract: Nonlamellar bioresorbable microparticles to which protein substances are bonded, and a method for preparing the microparticles, comprising: (i) preparing the microparticles from at least one bioresorbable polymer without stabilizer and without surfactant; and (ii) bonding the protein substances to the microparticles obtained in step (i) without surfactant.Type: ApplicationFiled: January 11, 2013Publication date: June 27, 2013Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)Inventor: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
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Publication number: 20130156725Abstract: The present invention relates to a synthetic polypeptide which is a random linear pentapolymer comprising alanine, glutamic acid, lysine, tyrosine and phenylalanine and use thereof in treating autoimmune diseases, in particular multiple sclerosis.Type: ApplicationFiled: February 11, 2013Publication date: June 20, 2013Applicant: MAPI PHARMA LTD.Inventor: MAPI PHARMA LTD.
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Patent number: 8450448Abstract: A biopolyester which is poly(3-hydroxyalkanoate) or poly(3-hydroxyalkanoate) copolymer and has a reduced calcium content. It has improved thermal stability due to the reduced calcium content.Type: GrantFiled: January 27, 2012Date of Patent: May 28, 2013Assignee: RikenInventors: Hideki Abe, Yoshiharu Doi
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Publication number: 20130129666Abstract: The invention provides a polymer based material comprising a water binding agent present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. The invention also provides a polymer based material comprising a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. The invention further provides a pharmaceutical composition comprising the aforesaid polymer based material, which can be used for treatment of bone, cartilage and/or periodontal defects.Type: ApplicationFiled: January 11, 2013Publication date: May 23, 2013Applicant: SCIL TECHNOLOGY GMBHInventor: Scil Technology GmbH
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Publication number: 20130122063Abstract: A method of uncoupling mitochondria in a subject including administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A method of decreasing reactive oxygen species and decreasing detrimental loading of Ca2+ into mitochondria is provided, including administering a pharmaceutically effective amount of nanotubes into the subject. A method of reducing weight, treating cancer, reducing the effects of traumatic brain injury, or reducing the effects of ageing, in a subject including administering a pharmaceutically effective amount of nanotubes into the subject is also provided.Type: ApplicationFiled: December 18, 2012Publication date: May 16, 2013Applicant: University of Kentucky Research FoundationInventor: University of Kentucky Research Foundation
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Patent number: 8440209Abstract: The invention relates to adhesives for medical applications and methods of their preparation and use.Type: GrantFiled: March 1, 2011Date of Patent: May 14, 2013Assignee: Stryker Trauma GmbHInventors: Andreas Speitling, Philip Procter, Joachim Schomburg, Christian Schultz, Wolf-Dieter Jülich, Ulrike Lindequist, Frieder Schauer, Annett Mikolasch, Katrin Manda
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Publication number: 20130115187Abstract: The present invention relates to a silicon-containing, biodegradable material for preventing and/or treating diseases that are associated with reduced and/or disturbed angiogenesis and/or diseases for which an increased rate of angiogenesis is beneficial to the healing process.Type: ApplicationFiled: February 22, 2011Publication date: May 9, 2013Applicant: BAYER INNOVATION GMBHInventors: Iwer Baecker, Christoph Suschek, Magda Ulrich, Bouke Boekema
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Publication number: 20130115186Abstract: The present invention relates to a silicon-containing, biodegradable material for preventing and/or treating diseases that are associated with increased interleukin-1? and/or interleukin-6 and/or interleukin-8 activity and/or that can be treated by lowering said cytokine activity.Type: ApplicationFiled: February 22, 2011Publication date: May 9, 2013Applicant: BAYER INNOVATION GMBHInventors: Iwer Baecker, Christoph Suschek
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Patent number: 8431114Abstract: Tissue adhesives formed by reacting an oxidized polysaccharide with a water-dispersible multi-arm polyether amine, wherein at least three of the arms are terminated by primary amine groups, are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described.Type: GrantFiled: October 6, 2005Date of Patent: April 30, 2013Assignee: Actamax Surgical Materials, LLCInventors: George K. Kodokian, Samuel David Arthur
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Publication number: 20130101547Abstract: The present specification generally relates to compositions comprising a thermoresponsive polymer and methods of treating a soft tissue condition using such compositions.Type: ApplicationFiled: October 16, 2012Publication date: April 25, 2013Applicant: ALLERGAN, INC.Inventor: Allergan, Inc.
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Publication number: 20130101672Abstract: The invention provides a drug-polymer nanoconjugate that includes a drug covalently bonded to a polymer. The nanoconjugate can include a block copolymer coating and/or an albumin coating. The drug of the drug-polymer nanoconjugate can be one or more of a variety of therapeutic agents linked to the polymer through ether or thioether linkages formed from hydroxyl or thiol groups of the drug. The albumin coating can substantially or completely retard or prevent aggregation of the nanoconjugates in solid form or in solution. The invention further provides compositions that include a plurality of drug-polymer nanoconjugates, as well as methods for using the drug-polymer nanoconjugates, such as in therapeutic or diagnostic applications.Type: ApplicationFiled: December 23, 2010Publication date: April 25, 2013Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Jianjun Cheng, Rong Tong
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Patent number: 8426474Abstract: Novel wash and carrier solutions ideally suited for topical administration (e.g., as wash solutions and as carrier solutions). The solutions described herein are non-toxic, non-irritating, isotonic, possess non-specific broad-spectrum antimicrobial properties, and have an alkaline pH. Also disclosed are sterile preparations of the solutions and methods of using the same.Type: GrantFiled: March 15, 2011Date of Patent: April 23, 2013Assignee: Teva Animal Health, Inc.Inventors: Richard Farng, Steven Mrha
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Patent number: 8425894Abstract: Use of the one or more oligomers of lactic acid with the following formula (I) wherein n is an integer from 2 to 25 such as, e.g., from 2 to 20, from 3 to 25, from 3 to 20, from 2 to 15, from 3 to 15, from 2 to 10, from 3 to 10, from 4 to 10, or from 4 to 9 or a lactic acid oligomeric product for the prophylaxis and/or treatment of a disease or condition that benefit of an acidic environment especially a gynaecological infection such as a bacterial infection, such as bacterial vaginosis, unspecific colpitis, senile colpitis, cervicitis, and urethritis, a fungal infection, such as candidosis (Candida albicans), cryptococcosis, actinomycosis, or a viral infection, such as Human Immunodefiency Virus (HIV), Herpes Simplex Virus (HSV), Human Papilloma Virus (HPV).Type: GrantFiled: March 28, 2008Date of Patent: April 23, 2013Assignee: Laccure ABInventors: Greg Batcheller, Thomas Hedner, Joergen Johnsson, Werner Schubert, Christer Sjoegren, Olov Sterner, Malgorzat Sznitowska
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Publication number: 20130089512Abstract: New heteroaryl imidazolone derivatives having the chemical structure of formula (I) are disclosed, as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).Type: ApplicationFiled: June 14, 2011Publication date: April 11, 2013Inventors: Paul Robert Eastwood, Jacob Gonzalez Rodriguez, Elena Gomez Castillo, Jordi Bach Taña
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Publication number: 20130089576Abstract: Implant devices and structures that reduce inflammation and promote healing of the area of implant. Specifically, the use of shape memory open cell biocompatible polymer foams for implants that assist in and promote healing and especially in filling and sealing aneurisms.Type: ApplicationFiled: October 2, 2012Publication date: April 11, 2013Applicants: The Texas A&M University System, Lawrence Livermore National Security, LLCInventors: Lawrence Livermore National Security, LLC, The Texas A&M University System
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Patent number: 8404779Abstract: A tissue adhesives and sealant formed by reacting a polyglycerol aldehyde with a water-dispersible, multi-arm amine is described. The tissue adhesive and sealant may be useful for medical and veterinary applications, including, but not limited to, wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and to prevent post-surgical adhesions.Type: GrantFiled: March 26, 2010Date of Patent: March 26, 2013Assignee: Actamax Surgical Materials LLCInventor: Henry Keith Chenault
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Publication number: 20130071349Abstract: The present invention provides a method of treating glaucoma, the method comprising the step of placing a polymer in an eye of a patient, which biologically degrades over a period of time to release biodegradants, which are effective to lower the intraocular pressure of the patient, thereby treating glaucoma. Said polymer is preferably selected from the group consisting of polymers of lactic acid, glycolic acid and/or mixtures thereof. More preferably the polymer is a copolymer of lactic acid and glycolic acid, e.g. a copolymer comprising from 50 to 100% lactic acid and from 0 to 50% glycolic acid, by weight.Type: ApplicationFiled: March 1, 2011Publication date: March 21, 2013Applicant: ALLERGAN, INC.Inventors: Michael R. Robinson, Susan S. Lee, Scott M. Whitcup
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Patent number: 8394393Abstract: A composite material containing polymeric nanofibers, themselves containing NO-donor molecules, imbibed with an elastomer matrix is permeable to both water and gas so that dissociation reactions in the presence of water releases NO gas in a sustained manner. The NO-donor nanofibers may be formed by synthesizing acceptable NO-donor molecules, blending such molecules in solution with PVP, PCL or PVAc, electrospinning the blend at relatively high voltage for form fiber mats, applying PDMS rubber to the fiber mat and crosslinking it. The resulting NO-releasing electrospun fiber composite may be used in medical devices such as catheters, stents, or vascular grafts, with the purpose of releasing nitric oxide within a controlled rate and for a sustained period of time, as well as other known medical applications for NO.Type: GrantFiled: April 6, 2011Date of Patent: March 12, 2013Assignee: Syracuse UniversityInventors: Patrick Mather, Ifeanyi Onyejewke, Kazuki Ishida
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Patent number: 8389661Abstract: The invention relates to an amphiphilic-BMP polymer complex which is physically and chemically stable and soluble in water, characterized in that: the amphiphilic polymers comprise a hydrophilic polysaccharide skeleton functionalized with hydrophobic substituents and hydrophilic groups the BMP is selected from the group of therapeutically active BMPs (Bone morphogenetic Proteins), the polymer/BMP mass ratio is lower than or equal to 700. The invention also relates to the process for preparing the amphiphilic-BMP polymer complex in an aqueous medium and in the absence of organic solvents likely to denature the protein. The invention also relates to therapeutic compositions of an amphiphilic-BMP polymer complex according to the invention.Type: GrantFiled: July 25, 2008Date of Patent: March 5, 2013Assignee: ADOCIAInventors: Gerard Soula, Olivier Soula, Remi Soula
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Publication number: 20130052142Abstract: Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Barium sulfate may also be provided to the core of the particles as a coating or absorbed within the core of the particles. The particles can be used to minimize blood flow to mammalian tissues by occluding at least a portion of a blood vessel of the mammal, or to deliver an active agent to a localized area within a body of a mammal by contacting a localized area with at least one of the particles. Further, the particles are useful in sustained release formulations including active agent(s) for oral administration, as tracer particles for injection into the bloodstream of a mammal or for use in enhanced ultrasound imaging.Type: ApplicationFiled: September 20, 2012Publication date: February 28, 2013Applicant: CeloNova BioSciences Germany GmbHInventors: Philipp Harder, Olaf Fritz, Ulf Fritz
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Publication number: 20130052156Abstract: This invention provides a method of inactivating non-enveloped virus particles. The method includes the step of contacting the virus with a virucidally-enhanced alcoholic composition that includes an alcohol, and enhancers selected from cationic oligomers and polymers, proton donors, chaotropic agents, and mixtures thereof.Type: ApplicationFiled: October 8, 2012Publication date: February 28, 2013Applicant: GOJO INDUSTRIES, INC.Inventor: GOJO Industries, Inc.
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Patent number: 8377477Abstract: The present invention relates to a method for preparing nonlamellar bioresorbable microparticles to which protein substances are bonded, characterized in that it comprises the steps of: (i) preparing said microparticles from at least one bioresorbable polymer without stabilizer and without surfactant, and (ii) bonding said protein substances to the microparticles obtained in step (i) without surfactant. It further relates to the bioresorbable microparticles thus obtained and use thereof in diagnosis and therapy.Type: GrantFiled: April 14, 2008Date of Patent: February 19, 2013Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Yasemin Ataman-Onal, Thierry Delair, Geneviève Inchauspe, Pascale Jeannin, Glaucia Paranhos-Baccala, Bernard Verrier
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Patent number: 8372387Abstract: The invention provides a therapeutic composition comprising an aqueous buffer, and a therapeutic agent that improves the functioning of a diseased heart by decreasing left ventricular end-diastolic pressure and simultaneously increasing left ventricular ejection without affecting the blood pressure or heart rate.Type: GrantFiled: April 4, 2008Date of Patent: February 12, 2013Assignee: Phrixus Pharmaceuticals, Inc.Inventor: Bruce Edward Markham
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Patent number: 8361455Abstract: One aspect of the present invention relates to a method of using peristalsis to force a polymer plug through a mammalian lumen, thereby removing any calculi and/or calculi fragments present in the lumen. In one embodiment, the method is used as an alternative to conventional lithotripsy. In another embodiment, the method is used in conjunction with lithotripsy, thereby removing the small calculi fragments that result from such procedures.Type: GrantFiled: April 27, 2006Date of Patent: January 29, 2013Assignees: Pluromed, Inc., The General Hospital CorporationInventors: W. Scott McDougal, Dianne E. Sacco, Alexander Schwarz, Jean-Marie Vogel
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Patent number: 8349309Abstract: A pharmaceutically-active polymeric compound of the general formula (I), Y-[Yn-LINK B-X]m-LINK B??(I) wherein (i) X is a coupled biological coupling agent of the general formula (II) Bio-LINK A-Bio??(II) wherein Bio is a biologically active agent fragment or precursor thereof linked to LINK A through a hydrolysable covalent bond; and LINK A is a coupled central flexible linear first segment of <2000 theoretical molecular weight linked to each of said Bio fragments; (ii) Y is LINK B-OLIGO; wherein (a) LINK B is a coupled second segment linking one OLIGO to another OLIGO and an OLIGO to X or precursor thereof; and (b) OLIGO is a short length of polymer segment having a molecular weight of less than 5,000 and comprising less than 100 monomeric repeating units; (iii) m is 1-40; and (iv) n is selected from 2-50. The compounds are useful as biomaterials, particularly, providing antibacterial activity in vivo.Type: GrantFiled: June 3, 2010Date of Patent: January 8, 2013Assignee: Interface Biologics Inc.Inventors: J. Paul Santerre, Mei Li
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Patent number: 8349346Abstract: A highly antimicrobial composition having characteristics of a lactic acid polymer such as biodegradability is prepared by combining a lactic acid oligomer with a metal salt thereof.Type: GrantFiled: November 5, 2009Date of Patent: January 8, 2013Assignee: Koken Ltd.Inventors: Hiroshi Imai, Kazushi Kimura
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Patent number: 8343551Abstract: Nanocomposite particles having good solubility and redispersibility in water are provided. The nanocomposite particles include a sugar material and nanoparticles containing a drug to be delivered and a biodegradable polymer, the sugar material being disaccharide, and a mass ratio of the nanoparticles to the disaccharide being within the range of from 40:60 to 60:40.Type: GrantFiled: March 16, 2007Date of Patent: January 1, 2013Assignee: Tokyo University of Science Educational Foundation Administrative OrganizationInventors: Kimiko Makino, Hiroshi Terada, Takehisa Nakajima, Keishiro Tomoda
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Patent number: 8343474Abstract: The invention relates to new compounds of Formula 1: [(O3/2)Si CH2CH2SX]a [Si(O4/2)]b[Si(O3/2V)]c. The compounds are useful as scavengers for the removal of unwanted organic and inorganic compounds, for solid phase extraction, for solid phase synthesis, for acid and metal mediated heterogeneous catalysis, for metal ion abstraction and for the immobilization of bio-molecules.Type: GrantFiled: February 9, 2007Date of Patent: January 1, 2013Assignee: Phosphonics Ltd.Inventors: John Robert Howe Wilson, Alice Caroline Sullivan, Siud Pui Man
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Publication number: 20120328683Abstract: The present application relates to oligomeric antimicrobial compounds and compositions comprising the same. The oligomers are formed by polymerizing aminoalkyl (meth)acrylate or aminoalkyl (meth)acrylamide monomer(s). In addition to imparting materials with broad spectrum antimicrobial activity, the oligomers can impart antimicrobial activity to substrates such as hair and skin.Type: ApplicationFiled: June 20, 2012Publication date: December 27, 2012Inventors: Zhiqiang Song, Ted Deisenroth