Abstract: Binding molecules, such as human monoclonal antibodies, that bind to influenza virus comprising HA of the H3 subtype, such as H3N2, and have a broad neutralizing activity against such influenza virus. Provided are nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H3N2 infection. The antibodies may provide cross-subtype protection, such that infections with H3, H7, and/or H10-based influenza subtypes can be prevented and/or treated.
Type:
Grant
Filed:
May 6, 2010
Date of Patent:
June 25, 2013
Assignee:
Crucell Holland B.V.
Inventors:
Mark Throsby, Robert Heinz Edward Friesen, Theodorus Hendrikus Jacobus Kwaks, Mandy Antonia Catharina Jongeneelen
Abstract: A cereal bran fortified with an effective amount of select additives such as vitamins, minerals, and essential dietary fats to promote digestive health. The fortified cereal bran can be used as a dietary supplement or as an added ingredient to fortify various food products. The additive used herein is an effective amount of vitamin D, selenium, calcium, magnesium, folic acid and omega 3 fatty acids.
Abstract: A dual action antifungal nail coat composition and method of use for ameliorating or preventing fungal infection of the nails, and onychomycosis, in particular, is disclosed. Composition embodiments in the form of one-coat type and two-coat type suitable for daily fungicidal regimens are disclosed. A preferred antifungal nail coat composition comprises an effective fungicidal amount of antifungal agent, a permeation enhancing amount of a substantially non-volatile, permeation enhancer, a film-forming amount of a hydrophilic polymer, and a pharmaceutically acceptable, volatile carrier. The composition provides a substantially water-soluble fungicidal coating on contacting a fungally susceptible or infected nail.
Type:
Grant
Filed:
March 22, 2004
Date of Patent:
December 9, 2008
Assignee:
NexMed Holdings, Inc.
Inventors:
Stanley W. Kepka, Y. Joseph Mo, Hang-Yong Wang, Mingqi Lu, William R. Pfister
Abstract: A molecule capable of potentiating immune responses is described, as well as methods for using the molecule to enhance immune responses and enhance dendritic cell function. Also described are compositions containing the molecule and methods for using the compositions to treat or immunize individuals.
Type:
Grant
Filed:
July 8, 2005
Date of Patent:
June 24, 2008
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Larry R. Pease, Moses Rodriguez, Daren Ure, Loc T. Nguyen, Suresh Radhakrishnan
Abstract: PGF.sub..alpha. compounds are disclosed having as the lower side chain ##STR1## in which one of R.sub.4 and R.sub.5 hydroxyl and the other is alkoxy R.sub.6 is hydrogen or alkyl, m is 0-3, E represents oxygen or sulphur and R is hydrogen, halogen, alkyl, alkoxy or trihaloalkyl.
Type:
Grant
Filed:
May 2, 1978
Date of Patent:
March 25, 1980
Assignee:
Farmitalia Certo Erba S.p.A.
Inventors:
Carmelo Gandolfi, Franco Faustini, Walter Moretti, Mario M. Usardi, Roberto Ceserani