Three Or More Amide Groups Are Attached Directly To The Same Benzene Ring By Nonionic Bonding Patents (Class 424/9.452)
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Publication number: 20090010853Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.Type: ApplicationFiled: February 14, 2007Publication date: January 8, 2009Inventors: Hanno Priebe, Duncan Wynn, Robert James Domett Nairne
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Publication number: 20080317675Abstract: The present invention generally relates to nonionic x-ray contrast media formulations, radiological compositions containing such agents and methods for x-ray visualization utilizing such compositions. The invention especially relates to injectable radiological compositions for x-ray visualization comprising a pharmaceutically acceptable vehicle and a mixture of a monomer, being a triiodo-substituted benzene nucleus, and a dimer, being two linked triiodo-substituted benzene nuclei, such that the mixture demonstrates favorable properties.Type: ApplicationFiled: March 11, 2005Publication date: December 25, 2008Inventors: Muthunadar P. Periasamy, Brian D. Doty
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Patent number: 7282607Abstract: The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.Type: GrantFiled: August 16, 2006Date of Patent: October 16, 2007Assignee: Bracco Imaging, S.p.A.Inventors: Richard A. Lorenzini, Ashok V. Bhatia, Steven A. Chamberlin, Keith A. Drengler, John J. Hufnagel, Xiu C. Wang
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Patent number: 7250153Abstract: This invention comprises new formulations of radiographic contrast media including dimeric non-ionic media, with an organic amine and a carboxylic acid. Formulations of this invention increase the biological tolerance of such media, thereby increasing their safety.Type: GrantFiled: November 5, 2003Date of Patent: July 31, 2007Assignee: Biophysica Research, Inc.Inventors: Milos Sovak, Allen L. Seligson, Ronald C. Terry
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Publication number: 20070148096Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a benzene scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.Type: ApplicationFiled: December 14, 2006Publication date: June 28, 2007Inventors: Lars-Goran Wistrand, Mikkel Thaning, Oskar Axelsson, Sven Andersson
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Patent number: 7115778Abstract: The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.Type: GrantFiled: February 24, 2005Date of Patent: October 3, 2006Assignee: Bracco imaging, S.p.A.Inventors: Richard A. Lorenzini, Ashok V. Bhatia, Steven A. Chamberlin, Keith A. Drengler, John J. Hufnagel, Xiu C. Wang
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Patent number: 6974882Abstract: A process for the preparation of iodixanol by dimerization of 5-acetamido-N,N?-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (“Compound A”) in which, after the dimerization step, unreacted Compound A is precipitated from the reaction mixture and recovered for re-use. The process substantially increases the net yield of iodixanol and simplifies its purification.Type: GrantFiled: August 6, 2001Date of Patent: December 13, 2005Assignee: Amersham Health ASInventor: Ole Magne Homestad
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Patent number: 6943269Abstract: The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also disclosed.Type: GrantFiled: June 20, 2003Date of Patent: September 13, 2005Assignee: University of North Carolina - Chapel HillInventors: Don A. Gabriel, Laura J. Melton
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Patent number: 6897339Abstract: Purification process of iohexol comprising the treatment of said product with 1-methoxy-2-propanol either alone or mixed with other solvents.Type: GrantFiled: April 9, 2002Date of Patent: May 24, 2005Assignee: Chemi, S.p.A.Inventors: Stefano Turchetta, Pietro Massardo, Valentina Aromatario
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Patent number: 6875887Abstract: A compound and salts and enantiomers thereof, having the formula: wherein R7 is an acyl group.Type: GrantFiled: June 16, 2004Date of Patent: April 5, 2005Assignee: Bracco Imaging S.p.A.Inventors: Richard A. Lorenzini, Ashok V. Bhatia, Steven A. Chamberlin, Keith A. Drengler, John J. Hufnagel, Xiu C. Wang
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Publication number: 20050025711Abstract: This invention comprises new formulations of radiographic contrast media including dimeric non-ionic media, with an organic amine and a carboxylic acid. Formulations of this invention increase the biological tolerance of such media, thereby increasing their safety.Type: ApplicationFiled: November 5, 2003Publication date: February 3, 2005Inventors: Milos Sovak, Allen Seligson, Ronald Terry
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Patent number: 6803485Abstract: The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.Type: GrantFiled: February 26, 1999Date of Patent: October 12, 2004Assignee: Bracco Imaging S.p.A.Inventors: Richard A. Lorenzini, Ashok V. Bhatia, Steven A. Chamberlin, Keith A. Drengler, John J. Hufnagel, Xiu C. Wang
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Patent number: 6498273Abstract: The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also disclosed.Type: GrantFiled: May 25, 2001Date of Patent: December 24, 2002Assignee: The University of North CarolinaInventors: Don A. Gabriel, Laura J. Melton
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Patent number: 6448442Abstract: The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents of formula I wherein n is 0 or 1, and where n is 1 each C6R5 moiety may be the same or different; X denotes a bond or a group providing a 1 to 7 atom chain linking two C6R5 moieties or, where n is 0, X denotes a group R; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M1, two or three non-adjacent R groups in each C6R5 moiety being iodine and at least one R group in each C6R5 moiety being an M or M1 moiety; each M which may be the same or different, is a non-ionic hydrophilic moiety; and each M1 independently represents a —CHOHCON(R1)2 group wherein each R1, which may be the same or different, is a hydrogen atom, an OH group or a C1-6 alkoxy or optionally hydroxylated C1-5 alkyl group; at least one R group in the molecule being an M1 moiety; and isomers thereof.Type: GrantFiled: April 28, 2000Date of Patent: September 10, 2002Assignee: Amersham Health ASInventors: Torsten Almen, Fredrik Ek
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Publication number: 20020031475Abstract: The invention relates to the use of intravenous contrast agents for projection mammography and novel devices for carrying out projection mammography. The invention therefore relates to the use of intravenous contrast agents for producing a diagnostic medium for projection mammography. With the additional intravenous administration of contrast agent, projection mammography attains a sensitivity comparable to the most modern methods, such as magnetic resonance tomography (MRT) while having a wider range of applications and avoiding the cost of MRT. This novel method is simple and can be carried out without special inconvenience for the patients. It a) considerably improves sensitivity for demonstrating focal lesions in the mammae and b) provides additional information on the character of previously detected lesions.Type: ApplicationFiled: April 17, 2000Publication date: March 14, 2002Inventors: ULRICH SPECK, IRTEL VON BRENNDORFF
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Patent number: 6337422Abstract: The yellow polymorph of 5-amino-2,4,6-triiodo-N,N′-bis(2,3-dihydroxypropyl)-isophthalamide is described.Type: GrantFiled: November 12, 1999Date of Patent: January 8, 2002Assignee: Nycomed Imaging ASInventors: Dick Malthe-Sorenssen, Audun Aukrust
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Publication number: 20010056206Abstract: The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.Type: ApplicationFiled: February 26, 1999Publication date: December 27, 2001Inventors: RICHARD LORENZINI, ASHOK BHATIA, STEVE CHAMBERLIN, KEITH DRENGLER, JOHN HUFNAGEL, XIU WANG
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Patent number: 6310243Abstract: The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula C6R6 wherein three non-adjacent R groups are iodine and the remaining R groups are non-ionic, hydrophilic moieties, said compound being water soluble at 20° C. to a concentration of at least 350 mgl/ml and which in aqueous solution at 20° C. at a concentration of 350 mgl/ml has a viscosity no greater than 13.8 mPas.Type: GrantFiled: December 22, 1998Date of Patent: October 30, 2001Assignee: Nycomed Imaging ASInventors: Torsten Almen, Sven Andersson, Lars-Goran Wistrand, Klaes Golman, Oyvind Antonsen, Rune Fossheim, Unni Nordby Wiggen, Hakan Wikstrom, Tomas Klingstedt, Ib Luenbach, Arne Berg, Harald Dugstad
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Patent number: 6265610Abstract: The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also disclosed.Type: GrantFiled: January 11, 2000Date of Patent: July 24, 2001Assignee: The University of North Carolina at Chapel HillInventors: Don A. Gabriel, Laura J. Melton
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Patent number: 6262303Abstract: A process for the preparation of S-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzenedicarboxamide, comprising the formation of S-N,N′-bis[2-hydro-xy-1-(hydroxymethyl)ethyl]-5-[(2-(acetyloxy)-1-oxopro-pyl)amino]-2,4,6-triiodo-1,3-benzenedicarboxamide star-ting from S-(−)-5-[[2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride and 2-amino-1,3-propanediol in a solvent, characterized in that the solvent is selected from the group consisting of: lower alcohols, monoalkyl ether glycols and straight or branched cyclic alkyl ethers.Type: GrantFiled: April 30, 1999Date of Patent: July 17, 2001Assignee: Dibra S.p.A.Inventors: Nicola De Santis, Salvatore Incandela