X-ray Contrast Imaging Agent (e.g., Computed Tomography, Angiography, Etc.) Patents (Class 424/9.4)
  • Publication number: 20030206860
    Abstract: Disclosed is a medical device (5) and more particularly, an implantable biomaterial. The biomaterial comprises a radiopaque (22) collagenous biomaterial (10).
    Type: Application
    Filed: December 19, 2001
    Publication date: November 6, 2003
    Inventors: Mark W. Bleyer, Michael C. Hiles, Umesh H. Patel
  • Publication number: 20030206856
    Abstract: A method of evaluating the effects of administering an external stimuli or treatment such as a psychoactive compound, a drug, or an environmental influence like temperature, noise, vibration, light and similar sensory-perceived influences, on a subject's brain using imaging techniques with position emission tomography (PET). The method measures cerebral metabolism before and after administering the external stimuli or treatment, and employs a behavioral clamp to control behavioral influences on the subject's brain after administration of the external stimuli or treatment.
    Type: Application
    Filed: April 11, 2003
    Publication date: November 6, 2003
    Inventors: John T. Metz, Malcolm D. Cooper
  • Patent number: 6641797
    Abstract: Perfluoroalkyl-containing complexes with sugar radicals of general formula I in which R represents a monosaccharide or oligosaccharide radical that is bonded via the 1-OH position or 1-SH position, Rf means a perfluorinated carbon chain, K is a metal complex, and Y and Z represent linker groups, are suitable for intravenous lymphography, for tumor diagnosis and for infarction and necrosis imaging.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: November 4, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Publication number: 20030180220
    Abstract: A liposome containing a hydrophobic iodine compound such as a 1,3,5-triiodobenzene derivative having at least one substituent containing 18 or more carbon atoms as a membrane component, and an X-ray contrast medium containing the liposome for use in radiography of a vascular disease and the like.
    Type: Application
    Filed: May 15, 2003
    Publication date: September 25, 2003
    Inventors: Kazuhiro Aikawa, Hiroshi Kitaguchi
  • Patent number: 6623761
    Abstract: This invention relates to a novel process of manufacture of nanoparticles of substantially water insoluble materials from emulsions. The emulsions have the ability to form a single liquid phase upon dilution of the external phase, instantly producing dispersible solid nanoparticles. The formed nanoparticles have average diameter of about 10 to 200 nm and are suitable for drug delivery and targeting of water insoluble therapeutic or diagnostic agents. Examples of such agents are methotrexate, progesterone, testosterone, prednisolone, and ibuprofen. Such agents can be used in a wide range of therapeutic and diagnostic treatments including treatment for cancer, hormonal therapy, and pain management.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: September 23, 2003
    Inventor: EmadEldin M. Hassan
  • Publication number: 20030170173
    Abstract: This invention relates to contrast agents and the use of these contrast agents for diagnosis of diseases in humans and animals based on mapping of metabolic activity. The contrast agents can be used to identify tissue or cells with metabolic activity or enzymatic activity deviating from the normal. A contrast agent substrate changes pharmacodynamic and/or pharmacokinetic properties upon a chemical modification from a contrast agent substrate to a contrast agent product in a specific enzymatic transformation, thereby detecting areas of disease upon a deviation in the enzyme activity from the normal.
    Type: Application
    Filed: November 22, 2002
    Publication date: September 11, 2003
    Inventors: Jo Klaveness, Helge Tolleshaug, Alan Cuthbertson, Mari Ann Kulseth
  • Patent number: 6610547
    Abstract: The invention provides a method of contrast agent drug candidate selection which involves: (i) obtaining a combinatorial library comprising an admixture of potential contrast agent drug candidates each incorporating a reporter moiety which is detectable in the animate human or non-human animal body (e.g. mammalian, avian or reptilian body), said library comprising a plurality of said reporter moieties which are interdistinguishably detectable in said body; (ii) administering said library to an animate human or non-human animal body; (iii) identifying in vivo one or more of said reporter moieties which has a desired distribution and/or elimination pattern in said body and thereby identifying a member of said library which has said pattern site or a sub-set of said library which contains a member of said library which has said pattern.
    Type: Grant
    Filed: November 6, 2000
    Date of Patent: August 26, 2003
    Assignee: Amersham Health AS
    Inventors: Jo Klaveness, Harald Dugstad, Julian Cockbain
  • Patent number: 6599448
    Abstract: The present invention provides a radio-opaque composition including a polymer or monomer, wherein the polymer or monomer has a non-leachable radio-opaque moiety. The non-leachable radio-opaque moiety is covalently attached to the polymer or monomer.
    Type: Grant
    Filed: May 10, 2000
    Date of Patent: July 29, 2003
    Assignee: Hydromer, Inc.
    Inventors: Joseph A. Ehrhard, Jr., Patrick Hennessey
  • Patent number: 6596259
    Abstract: The present invention is directed to a complex comprising a redox-active metal cluster in a chemically inert shell. The inventive complex has the formula M8(&mgr;4-E)4(&mgr;-L)12X, where M is chosen from a transition metal, a lanthanide, an actinide and mixtures thereof; E is a chalcogenide; L is a bridging ligand; and X is a terminal ligand. The chemically inert shell enables the complex to exhibit structural stability over several oxidation states, and to exhibit reversible electrochemical reduction properties. A single reactor method of making this complex from simple starting materials is also disclosed. The active center further allows the octanuclear complex to be used in making supercluster assemblies that have electron transfer properties or in making contrasting agents for MRI applications, for example.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: July 22, 2003
    Assignee: University of Puerto Rico
    Inventor: Raphael G. Raptis
  • Publication number: 20030108611
    Abstract: Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the invention relates to methods of preparing and using such bioadhesive nanoparticulate compositions.
    Type: Application
    Filed: December 7, 2001
    Publication date: June 12, 2003
    Applicant: ELAN PHARMA INTERNATIONAL LTD.
    Inventors: H. William Bosch, Eugene R. Cooper, Simon L. McGurk
  • Publication number: 20030099596
    Abstract: The invention relates to the use of photodynamic therapy (PDT) to treat macular edemas, including DME, CRVO and BRVO. It provides an alternative to photocoagulation and the disadvantages associated therewith.
    Type: Application
    Filed: July 19, 2002
    Publication date: May 29, 2003
    Inventors: Janice North, Peter Hnik, H. Andrew Strong
  • Patent number: 6569403
    Abstract: A method of evaluating the effects of administering an external stimuli or treatment such as a psychoactive compound, a drug, or an environmental influence like temperature, noise, vibration, light and similar sensory-perceived influences, on a subject's brain using imaging techniques with positron emission tomography (PET). The method measures cerebral metabolism before and after administering the external stimuli or treatment, and employs a behavioral clamp to control behavioral influences on the subject's brain after administration of the external stimuli or treatment.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: May 27, 2003
    Assignee: Miicro, Incorporated
    Inventors: John T. Metz, Malcolm D. Cooper
  • Publication number: 20030091508
    Abstract: System and method for radiographic imaging of tissue using a non-radioactive, radio-opaque imaging agent that accumulates intracellularly in tissue in proportion to its functional, or physiological, activity. In one embodiment, the imaging agent is a cell-membrane permeable, radio-opaque, high affinity ligand for the intracellular enzyme hexokinase. The imaging agent is administered to a patient, and after an accumulation interval, radiographic images are acquired. The imaging agent preferentially accumulates in malignant tissue and increases its radio-opacity because of its elevated glucose metabolic rate relative to benign and normal tissue. The tissue being examined is transilluminated by X-ray beams with preselected different mean energy spectra, and a separate radiographic image is acquired during transillumination by each beam. An image processing system performs a weighted combination of the acquired images to produce a single displayed image.
    Type: Application
    Filed: June 14, 2002
    Publication date: May 15, 2003
    Applicant: Veritas Pharmaceuticals, Inc.
    Inventor: Jesse Salb
  • Publication number: 20030082104
    Abstract: An imaging method and apparatus, for small animal imaging, in which the object to be examined is treated with an activatable optical contrast medium, which preferably has a metabolically activatable mark, and irradiated by a first optical excitation source. The first radiation reflected from the object is detected by a first optical detector, and simultaneously irradiated by a second tomographic excitation source, while the second radiation transferred from the object is detected by a second tomographic detector. In this case, the second tomographic excitation source advantageously generates an X-ray radiation, so that the resulting CT image can be superposed with the optical image in order to evaluate morphological and functional information.
    Type: Application
    Filed: October 21, 2002
    Publication date: May 1, 2003
    Inventor: Thomas Mertelmeier
  • Patent number: 6548047
    Abstract: The present invention describes, among other things, the surprising discovery that gaseous precursor filled compositions are profoundly more effective as acoustically active contrast agents when they are thermally preactivated to temperatures at or above the boiling point of the instilled gaseous precursor prior to their in vivo administration to a patient. Further optimization of contrast enhancement is achieved by administering the gaseous precursor filled compositions to a patient as an infusion. Enhanced effectiveness is also achieved for ultrasound mediated targeting and drug delivery.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: April 15, 2003
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventor: Evan C. Unger
  • Patent number: 6540979
    Abstract: Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a period of time sufficient to reduce the density of breast tissue prior to generating an image of the breast tissue, for example by mammography, to detect a lesion in the breast tissue. Packaged formulations for reducing breast density in a subject prior to generating an image of the subject's breast tissue, comprising an LHRH antagonist packaged with instructions for using the LHRH antagonist to reduce breast density in a subject prior to imaging the breast tissue, are also disclosed.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: April 1, 2003
    Assignee: Praecis Pharmaceuticals, Inc.
    Inventor: Marc B. Garnick
  • Publication number: 20030059372
    Abstract: Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.
    Type: Application
    Filed: October 28, 2002
    Publication date: March 27, 2003
    Inventors: Thomas J. Whalen, Chinh N. Tran, Noah M. Roth, Richard J. Greff
  • Patent number: 6538026
    Abstract: A composition comprising of a monomer component comprised of at least one alkyl cyanoacrylate and at least one inhibitor, and a second component comprised of a resultant aggregate structure formed from an alkyl cyanoacrylate monomer, an alkyl esterified fatty acid and an opacificant agent where said composition forms a resultant aggregate structure when said composition contacts an anionic environment. The compositions are useful for filling, occluding, partially filling or partially occluding an unfilled volume or space in a mass in an anionic environment. The composition are also useful for ablating diseased or undesired tissue by cutting off the blood supply to the tissue.
    Type: Grant
    Filed: May 23, 2000
    Date of Patent: March 25, 2003
    Assignee: Provasis Therapeutics, Inc.
    Inventors: Robert E. Krall, Charles W. Kerber, Kimberly Knox
  • Patent number: 6531111
    Abstract: Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: March 11, 2003
    Assignee: Micro Therapeutics, Inc.
    Inventors: Thomas J. Whalen, II, Chinh N. Tran, Noah M. Roth, Richard J. Greff
  • Patent number: 6528039
    Abstract: Substantially homogeneous aqueous suspensions of low density microspheres are presented as contrast media for imaging the gastrointestinal tract and other body cavities using computed tomography. In one embodiment, the low density microspheres are gas-filled. With computed tomography, the contrast media serve to change the relative density of certain areas within the gastrointestinal tract and other body cavities, and improve the overall diagnostic efficacy of this imaging method.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: March 4, 2003
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventor: Evan C. Unger
  • Patent number: 6524553
    Abstract: The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.
    Type: Grant
    Filed: March 30, 1999
    Date of Patent: February 25, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventor: Thomas David Harris
  • Patent number: 6524554
    Abstract: The present invention provides novel radiopharmaceuticals comprising one to three pentapeptides, X1X2X3X4X5, independently attached to a metal chelator or bonding moiety, Ch, to which is attached a Tc-99m, Re-186, or Re-188, optionally further comprising a linking group, Ln, between-the peptides and the chelator or bonding moiety. The pentapeptide sequence binds to the tuftsin receptor and is attached at the N-terminus to Ln or Ch. These radiopharmaceuticals are useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation in a patient, and methods of diagnosing diseases associated with infection or inflammation in patients in need of such diagnosis.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: February 25, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: David Scott Edwards, Milind Rajopadhye
  • Patent number: 6517814
    Abstract: Macrocyclic chelant are disclosed, as well as chelates of the chelants with metal ions to form radiopharmaceutical and radioactive, MRI and X-ray or CT imaging compounds and compositions. Therapeutic and imaging methods of use are also disclosed.
    Type: Grant
    Filed: December 27, 2001
    Date of Patent: February 11, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventor: Shuang Liu
  • Patent number: 6514480
    Abstract: To lessen the allergic or pseudoallergic side effects of radiological contrast agents, the contrast agent is preincubated in vitro with a reactive medium such as human or animal blood protein, whereupon the resultant reaction products are separated off from the contrast agent by ultrafiltration.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: February 4, 2003
    Assignee: Amersham Health AS
    Inventor: Bernhard Sixt
  • Patent number: 6511649
    Abstract: The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The present invention further provides novel compounds useful for imaging atherosclerosis, restenosis, cardiac ischemia, and myocardial reperfusion injury. The present invention still further provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety.
    Type: Grant
    Filed: June 21, 2000
    Date of Patent: January 28, 2003
    Inventors: Thomas D. Harris, John A. Barrett, Alan P. Carpenter, Jr., Milind Rajopadhye
  • Patent number: 6511648
    Abstract: The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The present invention further provides novel compounds useful for imaging atherosclerosis, restenosis, cardiac ischemia, and myocardial reperfusion injury. The present invention still further provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: January 28, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Thomas D. Harris, Milind Rajopadhye
  • Patent number: 6506365
    Abstract: The invention relates to fibrin/fibrinogen binding conjugate comprising a fibrin/fibrinogen binding moiety, a substance capturing moiety capable of reversibly binding to a pharmaceutically active substance, and a pharmaceutically active substance, wherein the fibrin/fibrinogen binding moiety is bound to the substance capturing moiety, a kit for forming a depot for a pharmaceutically active substance and a method for producing a depot for a pharmaceutically active substance.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: January 14, 2003
    Assignee: Baxter Aktiengesellschaft
    Inventors: Heinz Redl, Walter Fuerst, Rudolf Kneidinger
  • Publication number: 20020192162
    Abstract: The present invention provides methods and compositions for imaging cell death in vivo, as well as methods and compositions for tumor radiotherapy.
    Type: Application
    Filed: April 3, 2002
    Publication date: December 19, 2002
    Applicant: Thesus Imaging Corporation
    Inventor: Allan M. Green
  • Patent number: 6493570
    Abstract: The present invention is directed to an apparatus and method of imaging and treatment using at least one photodynamic therapy (“PDT”) agent. In particular, the apparatus and method is for imaging and treating diseased tissue.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: December 10, 2002
    Assignee: Photogen, Inc.
    Inventors: H. Craig Dees, Timothy Scott
  • Patent number: 6479033
    Abstract: The invention concerns a composition for the treatment of tumors, of (i) at least one cytostatic drug component which is unencapsulated or is encapsulated in a PEG-, immuno-, or immuno/PEG liposome, (ii) at least one of lyophilized starch particles, degradable starch particles, and gelatine, in combination with (iii) a contrasting agent containing at least one of iodine, gadolinium, and magnetite.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: November 12, 2002
    Assignee: Max Delbrück Zentrum für Molekulare Medizin
    Inventors: Regina Reszka, Uwe Pohlen, Detlef Stiller, Gerd Berger, Matthias Lippmann
  • Patent number: 6475466
    Abstract: Disclosed are methods for treating endoleaks arising from endovascular repair of abdominal aortic aneurysms. The disclosed methods involve the in situ sealing of endoleaks after placement of an endovascular prostheses in the abdominal aorta. Sealing of endoleaks is achieved by injection of either a biocompatible polymer or prepolymer fluid composition into the endoleak which composition in situ solidifies to seal the leak. Preferably, the biocompatible fluid composition comprises a contrast agent to allow the clinician to visualize the sealing process.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: November 5, 2002
    Assignee: Micro Therapeutics, Inc.
    Inventors: Charlie Ricci, Bart Dolmatch, Andrew H. Cragg, Richard J. Greff
  • Patent number: 6476069
    Abstract: A composition useful as an embolic agent that selectively creates an embolic blockage in the lumen of a blood vessel, duct, fistula or other like body passageways by combining a monomer component and a second component wherein, said monomer component comprises of a alkyl cyanoacrylate monomer and at least one inhibitor agent; and said second component that functions as an opacificant agent and a polymerization retardant.
    Type: Grant
    Filed: January 29, 1999
    Date of Patent: November 5, 2002
    Assignee: Provasis Therapeutics Inc.
    Inventors: Robert E. Krall, Charles W. Kerber, Kimberly Knox
  • Patent number: 6476070
    Abstract: A composition comprising of a monomer component comprised of at least one alkyl cyanoacrylate and at least one inhibitor, and a second component comprised of a resultant aggregate structure formed from an alkyl cyanoacrylate monomer, an alkyl esterified fatty acid and an opacificant agent where said composition forms a resultant aggregate structure when said composition contacts an anionic environment. The compositions are useful for filling, occluding, partially filling or partially occluding an unfilled volume or space in a mass in an anionic environment. The composition are also useful for ablating diseased or undesired tissue by cutting off the blood supply to the tissue.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: November 5, 2002
    Assignee: Provasis Therapeutics Inc.
    Inventors: Robert E. Krall, Charles W. Kerber, Kimberly Knox
  • Patent number: 6468502
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: October 22, 2002
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Radüchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Patent number: 6461587
    Abstract: The invention relates to macrocyclic perfluoroalkylamides, their production and their use in diagnosis.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: October 8, 2002
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Detlev Suelzle, Wolfgang Schlecker, Bernd Raduechel, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Patent number: 6461589
    Abstract: Disclosed are a viscosity-standardized combination of solutions and a method of using the solutions for the diagnosis of dysphagia and for radiographic imaging of the oropharynx.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: October 8, 2002
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Jo Anne Robbins
  • Patent number: 6451980
    Abstract: An immunoassay method including reacting a sample from a patient with a bispecific antibody, wherein the bispecific antibody includes one antibody specific for a compound to be detected and a second antibody specific for a compound foreign to said patient sample, and subsequently reacting the patient sample with a polymer probe, wherein the polymer probe includes a compound recognized by the second antibody in the bispecific antibody complex and further includes at least two detectable signals; the bispecific antibody; and the polymer probe of the immunoassay method are disclosed.
    Type: Grant
    Filed: October 6, 1999
    Date of Patent: September 17, 2002
    Assignee: Ban-An Khaw
    Inventors: Ban-an Khaw, Jagat Narula
  • Publication number: 20020127632
    Abstract: Methods for enhancing contrast during imaging to assess cell and nuclear morphology of a sample. A contrast agent such as acetic acid, toluidine blue, hypertonic saline, hypotonic saline, Lugol's iodine, an absorbing dye, a liposome, or a contrast agent linked to a marker are applied to a sample. The sample is analyzed with an imaging device to create image data, and the sample is diagnosed using the image data.
    Type: Application
    Filed: March 28, 2001
    Publication date: September 12, 2002
    Inventors: Rebecca R. Richards-Kortum, Andres F. Zuluaga, Rebekah Drezek, Colin Smithpeter, Tom Collier
  • Patent number: 6432381
    Abstract: Particulate crystalline therapeutic substances are formulated with stabilizers to enhance contact between the crystalline therapeutic substances and the mucosal membranes to provide extended therapeutic effect.
    Type: Grant
    Filed: March 11, 1997
    Date of Patent: August 13, 2002
    Assignee: Elan Pharma International Limited
    Inventors: Gary G. Liversidge, W. Mark Eickhoff, Kathleen J. Illig, Pramod Sarpotdar, Stephen B. Ruddy
  • Patent number: 6426145
    Abstract: A radiopaque polymeric composition useful as a polymer coating on a substrate. The compositions are designed to be bioabsorbable and are particularly useful on implantable medical devices, such as vascular prostheses and the like.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: July 30, 2002
    Assignee: SciMed Life Systems, Inc.
    Inventor: Antonio Moroni
  • Publication number: 20020098150
    Abstract: A composition useful as an embolic agent that selectively creates an embolic blockage in the lumen of a blood vessel, duct, fistula or other like body passageways by combining a monomer component and a second component wherein, said monomer component comprises of a alkyl cyanoacrylate monomer and at least one inhibitor agent; and said second component that functions as an opacificant agent and a polymerization retardant.
    Type: Application
    Filed: January 29, 1999
    Publication date: July 25, 2002
    Inventors: ROBERT E. KRALL, CHARLES W. KERBER, KIMBERLY KNOX
  • Patent number: 6420436
    Abstract: This invention relates to a non-aqueous fluorocarbon composition for use in magnetic resonance imaging (MRI) or radiographic imaging (X-ray or computed tomography), particularly imaging of the gastrointestinal (GI) tract; an improved fluorocarbon composition with enhanced contrast effects in the GI tract; a fluorocarbon composition having improved palatability; a fluorocarbon composition for delivering drugs or bioactive agents; improved preparations for radiographic imaging or MRI; methods for producing and using such preparations; methods for improving the palatability of non-aqueous liquids; and methods for improving imaging.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: July 16, 2002
    Assignee: Alliance Pharmaceutical Corp.
    Inventor: W. Dean Kirkland
  • Publication number: 20020090339
    Abstract: Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter deliver.
    Type: Application
    Filed: October 11, 2001
    Publication date: July 11, 2002
    Inventors: Thomas J. Whalen, Chinh N. Tran, Noah M. Roth, Richard J. Greff
  • Patent number: 6409990
    Abstract: New macromolecular carriers for drugs and diagnostic agents are described that make use of the chemical attachment of new leashes to oligomeric backbone structures. The synthesis of these leashes and their facile creation, reaction and conjugation with chelators and ligands makes them ideal candidates for use in medicine, and especially diagnostics.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: June 25, 2002
    Assignee: The Regents of the University of California
    Inventor: David R. Vera
  • Publication number: 20020076378
    Abstract: The invention provides compounds comprising a linear, branched or dendrimeric polymer backbone with linked thereto at least one reporter moiety, said polymer backbone comprising a plurality of amine-containing acids. Such compounds may be linked to one or more targeting agents and are useful as therapeutic and diagnostic agents, in particular in medical imaging techniques.
    Type: Application
    Filed: January 29, 2002
    Publication date: June 20, 2002
    Applicant: NYCOMED IMAGING AS
    Inventors: Henry Wolfe, Kenneth Kellar
  • Patent number: 6406680
    Abstract: This invention describes a new type of X-ray contrast agents. It has been found that iodinated alkenes containing one or several C═C double bonds substituted with electronic neutral substituents and iodine can be used as X-ray contrast agents. Also new iodoalkene compounds are described.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: June 18, 2002
    Assignee: Nycomed Imaging AS
    Inventor: Hanno Priebe
  • Patent number: 6399043
    Abstract: 1,4,7,10-Tetraazacyclodedecane butyltriols of general formula IA in which R1 means hydrogen or a metal ion equivalent independent of one another and R2 means a butyltriol radical as well as their salts with organic or inorganic bases or amino acids are valuable pharmaceutical agents.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: June 4, 2002
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Heinz Gries, Hanns-Joachim Weinmann, Gabriele Schuhmann-Giampieri, Wolf-Rüdiger Press
  • Patent number: 6395254
    Abstract: The present invention relates to conjugates, comprising an active substance, a polypeptide and a polyether, a process for the production of such conjugates as well as their use.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: May 28, 2002
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Hannsjörg Sinn, Wolfgang Maier-Borst, Hans-Hermann Schrenk, Gerd Stehle, Heinz H. Fiebig
  • Publication number: 20020061278
    Abstract: The present invention provides a method for detecting chitin-containing organisms on an area of a person or animal by contacting the particular area with a dye that is capable of binding or conjugating to chitin and emitting fluorescence upon exposure to light. If a chitin-containing organism is present in the treated area, the chitin of the organism will bind or conjugate the dye and, upon exposure to light, the chitin-containing organisms may be visualized and removed. Also provided by the present invention are solutions and suspensions that contain a dye capable of binding or conjugating to a chitin-containing organism and emitting fluorescence upon exposure to light. The solutions and suspensions provided herein may be in the form of a shampoo, cream, lotion or detergent for the detection of chitin-containing organisms present in body hair, on the skin, clothing or the fur of animals.
    Type: Application
    Filed: November 17, 1998
    Publication date: May 23, 2002
    Inventors: EDWARD R. BURNS, MURRAY WITTNER, FAGIE FASKOWITZ
  • Patent number: 6387663
    Abstract: The present invention provides new compositions and methods to induce therapeutic angiogenesis locally utilizing a collagen binding domain to target an angiogenesis modulating agents. Fusion polypeptides containing a collagen binding domain linked to an angiogenesis modulating agent are provided, as are nucleic acid sequences encoding the fusion polypeptides. Also included are methods for locally altering circulation by administering a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or by administering a nucleic acid sequences encoding the fusion polypeptide. Tissue grafts in which isolated tissue is treated with a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or with a nucleic acid sequences encoding the fusion polypeptide are also provided, as are methods of making the grafts.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: May 14, 2002
    Assignee: University of Southern California
    Inventors: Frederick L. Hall, Erlinda M. Gordon, Vaughn A. Starnes, W. French Anderson