Stable Gas Bubbles Containing Or Intentional Solubilized Gas Containing Patents (Class 424/9.52)
  • Stable microbubble suspensions as enhancement agents for ultrasonic echography
    Patent number: 6187288
    Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: February 13, 2001
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Jean Brochot, Jérôme Puginier, Feng Yan
  • Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
    Patent number: 6183725
    Abstract: The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and stabilisers provides useful ultrasound contrast agents. At least one of the components (B) in the mixture is a gas whose molecular weight is greater than 80 daltons and whose solubility in water is below 0.0283 ml per ml of water at standard conditions. The presence of the first component (B) in the contrast medium may vary between 0.5 and 41 volume percent. The other component (A) of the ultrasound contrast media is a gas or a mixture of gases whose molecular weight is below 80 daltons. The second component is present in a proportion of between 59-99.5% by vol., and is preferably chosen from oxygen, air, nitrogen, carbon dioxide or mixtures thereof.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: February 6, 2001
    Assignee: Bracco Research S.A.
    Inventors: Feng Yan, Michel Schneider
  • Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes
    Patent number: 6180113
    Abstract: Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes are useful in tumor therapy and interventional radiology.
    Type: Grant
    Filed: February 19, 1997
    Date of Patent: January 30, 2001
    Assignee: Schering AG
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Rad{umlaut over (u)}chel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel
  • Contrast agents comprising an azeotropic mixture of two gases for ultrasound investigations
    Patent number: 6177061
    Abstract: A contrast agent for use in diagnostic studies, particularly ultrasound imaging, comprising a dispersion in an injectable aqueous medium of a biocompatible azeotropic mixture which is in gaseous form at 37° C., at least one component of said mixture being a halocarbon having a molecular weight of at least 100.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: January 23, 2001
    Assignee: Nycomed Imaging AS
    Inventors: Jo Klaveness, Roald Skurtveit, Pål Rongved, Lars Hoff
  • Agents and methods for enhancing contrast in ultrasound imaging
    Patent number: 6177062
    Abstract: The invention relates to ultrasonic contrast agents comprising microparticles which comprise synthetic biodegradable polymers and a gas and/or a fluid with a boiling point below 60° C., processes for the preparation thereof and their use as diagnostic and therapeutic agents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 23, 2001
    Assignee: Schering Aktiengesellschaft
    Inventors: Michael Stein, Dieter Heldmann, Thomas Fritzsch, Joachim Siegert, Georg Roessling