Pancreatin Patents (Class 424/94.21)
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Publication number: 20110008291Abstract: The present invention provides a novel method for treating oral conditions and upper gastrointestinal conditions in a subject by providing an inventive oral dosage form of a pharmaceutical composition comprising an effective amount of at least one antifungal and optionally a flavor modifier and/or salivation component such as an herbal component. In the present invention, the subjects have either not been diagnosed or do not have active or recurrent fungal infections. Specifically, the present invention is directed to chewable dosage forms.Type: ApplicationFiled: August 16, 2010Publication date: January 13, 2011Inventor: Stuart L. Weg
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Publication number: 20100270183Abstract: Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.Type: ApplicationFiled: July 8, 2010Publication date: October 28, 2010Applicant: EURAND PHARMACEUTICALS LTDInventors: Giovanni Ortenzi, Marco Marconi, Luigi Mapelli
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Publication number: 20100196344Abstract: The present invention relates to compositions for the treatment of conditions, including pancreatic insufficiency. The compositions of the present invention comprise lipase, protease and amylase in a particular ratio that provides beneficial results in patients, such as those afflicted with pancreatic insufficiency. This invention also relates to methods using such compositions for the treatment of pancreatic insufficiency.Type: ApplicationFiled: April 5, 2010Publication date: August 5, 2010Applicant: Cystic Fibrosis Foundation Therapeutics, Inc.Inventors: Alexey L. Margolin, Bhami C. Shenoy, Frederick T. Murray, Anthony Christopher Lee Stevens
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Publication number: 20100151010Abstract: The invention relates to a medicament in a multilayer form, containing a) a core with a pharmaceutical agent, b) an inner coating, 50 to 95 percent by weight of which arc composed of a (co)polymer comprising 95 to 100 percent by weight of radically polymerized vinylic monomers with neutral side groups and 0 to 5 percent by weight of monomers with anionic side groups, c) an outer coaling made of a copolymer comprising 75 to 95 percent by weight of radically polymerized C1 to C4 alkyl esters of acrylic acid or methacrylic acid and 5 to 25 percent by weight of (meth)acrylate monomers with an anionic group in the alkyl radical. Said medicament further contains 5 to 30 percent by weight of common pharmaceutical auxiliaries, particularly emollients. The inventive medicament is characterized in that the inner coaling contains 5 to 50 percent by weight of common pharmaceutical auxiliaries which are no expanding agents while the amount of expanding agents provided is less than 5 percent by weight.Type: ApplicationFiled: May 18, 2005Publication date: June 17, 2010Applicant: ROEHM GMBHInventors: Hans-Ulrich Petereit, Christian Meier
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Patent number: 7658918Abstract: Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.Type: GrantFiled: October 9, 2009Date of Patent: February 9, 2010Assignee: Eurand Pharmaceuticals Ltd.Inventors: Giovanni Ortenzi, Marco Marconi, Luigi Mapelli
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Publication number: 20100021537Abstract: Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.Type: ApplicationFiled: October 9, 2009Publication date: January 28, 2010Inventors: Giovanni Ortenzi, Marco Marconi, Luigi Mapelli
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Publication number: 20090324572Abstract: A therapeutic composition for the treatment of the symptoms of Williams Syndrome and the method for preparing the therapeutic agents is disclosed. The therapeutic composition is a stable pharmaceutical composition comprising one or more digestive and/or pancreatic enzymes. The therapeutic composition may be manufactured by a variety of encapsulation technologies. Delivery of the therapeutic composition may be made orally, through injection, by adherence of a medicated patch or other method. Further, a method of using fecal chymotrypsin level as a biomarker for the presence of Williams Syndrome, or the likelihood of an individual to develop Williams Syndrome is disclosed.Type: ApplicationFiled: June 26, 2009Publication date: December 31, 2009Inventor: Joan M. Fallon
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Publication number: 20090311235Abstract: Methods of enabling or improving the ability of a hydrogel to swell in the stomach of an animal and/or increasing the amount of time said hydrogel remains swollen in the stomach are described herein. In one embodiment, a polymer is administered in combination with one or more pH modifying agents which raise and maintain the pH of the micro environment of the polymer and/or the stomach in order inducing swelling in the polymer. The polymer can be a homopolymer, a copolymer, or a polymer blend or composite. In one embodiment, the polymer is a superabsorbent polymer (“SAP”). The polymers can also be administered with one or more active agents, such as appetite suppressants. The pH modifying agent and/or the active agent can be administered simultaneously with the polymer in the same dosage form, simultaneously with the polymer in separate dosage forms, or sequentially. The compositions are formulated for oral administration.Type: ApplicationFiled: March 13, 2009Publication date: December 17, 2009Inventors: Eric Elenko, Eyal S. Ron, Yishai Zohar
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Publication number: 20090010913Abstract: A liniment composition for reversing or retarding the growth of cancerous skin tumors comprising primarily, pancreatin, pepsin, betaine HCL, emulsified vitamin A, and zinc, pancrelipase, fenugreek, papain, amylase and ox bile extract, with optional trace amounts of other ingredients.Type: ApplicationFiled: July 3, 2007Publication date: January 8, 2009Inventor: James R. Privitera
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Publication number: 20080145355Abstract: Disclosed are alginate formulations that help protect digestive enzymes in the formulations from denaturation during passage through the acidic stomach environment, and from other sources, following ingestion. The formulation changes consistency to permit release of the enzymes in the less-acidic gut. They contain monovalent alginate salts (sodium, potassium and ammonium alginate) but are designed to not include significant quantities of compounds which would generate divalent ions and thereby convert the monovalent alginate to a divalent alginate when exposed to aqueous solution. A buffering agent that does not react with the digestive enzymes or the monovalent alginate, and which does not generate divalent ions on exposure to aqueous solution, can be included. A chelating agent which binds divalent ions may be administered with the formulation. Additionally, the formulation may be admixed with inert excipients suitable for oral delivery. It is preferable that the ingredients are dried before formulation.Type: ApplicationFiled: December 14, 2007Publication date: June 19, 2008Inventor: Randolph S. Porubcan
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Publication number: 20080107639Abstract: The present invention discloses novel uses for energy homeostasis regulating proteins and polynucleotides encoding this in the diagnosis, study, prevention, and treatment of metabolic diseases and disorders.Type: ApplicationFiled: January 19, 2005Publication date: May 8, 2008Applicant: DEVELOGEN AKTIENGESELLSCHAFTInventor: Daria Onichtchouk
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Patent number: 7211278Abstract: treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.Type: GrantFiled: February 13, 2004Date of Patent: May 1, 2007Assignee: Kao CorporationInventors: Naoko Tsuji, Shigeru Moriwaki, Atsushi Ohuchi, Yasuto Suzuki
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Patent number: 7166281Abstract: A pharmaceutical composition for relieving the itch, pain, and swelling resulting from insect bites and stings, and methods for producing and using the composition. The method preferably comprises topically applying to the affected area the composition which contains an abrasive ingredient and an anti-itch enzyme, both of which are dispersed in a carrier containing effective amounts of emulsifiers, and/or dispersants and may take the form of a powder, liquid, or paste. The final pharmaceutical composition is preferably made in the form of a cream or lotion so that it can be rubbed directly on the skin at the affected site. The pharmaceutical composition for relieving the itch, pain, and swelling resulting from insect bites and stings disclosed herein may also contain an anesthetic and/or antibiotic.Type: GrantFiled: April 30, 2001Date of Patent: January 23, 2007Assignee: American Natural Technology Sciences, Inc.Inventor: Patrick Kennedy
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Patent number: 7153504Abstract: The present invention provides stabilized pancreas products useful, for example, as an animal feed additives. The invention also provides for feed additives and feed rations comprising a stabilized pancreas product. Further, the invention provides for methods of making stabilized pancreas products. The present invention also provides for methods of supplementing an animal feed utilizing stabilized pancreas products.Type: GrantFiled: July 30, 2004Date of Patent: December 26, 2006Assignee: CAN Technologies, Inc.Inventors: Andrew J. La Follette, Jennifer L.G. van de Ligt, Christiaan P.A. van de Ligt, Mark D. Newcomb, W. Michael Craig, Kevin Touchette
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Patent number: 7056499Abstract: The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.Type: GrantFiled: February 8, 2002Date of Patent: June 6, 2006Assignee: Kao CorporationInventors: Naoko Tsuji, Shigeru Moriwaki, Atsushi Ohuchi, Yasuto Suzuki
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Patent number: 6676933Abstract: A pharmaceutical composition contains mosapride, pancreatin and optionally simethicone and is used for treating, preventing or alleviating the symptoms of a gastrointestinal disorder. The pharmaceutical composition is provided in an oral dosage form for administration to a subject.Type: GrantFiled: May 23, 2001Date of Patent: January 13, 2004Assignee: Osmotica Corp.Inventors: Juan A. Vergez, Marcelo A. Ricci, Joaquina Faour
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Patent number: 6548556Abstract: This invention relates to an enzymatic anhydrous hydrophilic wound debrider that uses in combination a proteolytic enzyme and an anhydrous hydrophilic poloxamer carrier.Type: GrantFiled: December 27, 2000Date of Patent: April 15, 2003Assignee: Healthpoint, Ltd.Inventors: David W. Hobson, David P. Jones, Katarzyna Koster, Pilar P. Duque
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Publication number: 20030007962Abstract: A pharmaceutical composition contains mosapride, pancreatin and optionally simethicone and is used for treating, preventing or alleviating the symptoms of a gastrointestinal disorder. The pharmaceutical composition is provided in an oral dosage form for administration to a subject.Type: ApplicationFiled: May 23, 2001Publication date: January 9, 2003Inventors: Juan A. Vergez, Marcelo A. Ricci, Joaquina Faour
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Publication number: 20020146404Abstract: The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.Type: ApplicationFiled: February 8, 2002Publication date: October 10, 2002Applicant: Kao CorporationInventors: Naoko Tsuji, Shigeru Moriwaki, Atsushi Ohuchi, Yasuto Suzuki
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Patent number: 6426099Abstract: An herbal formulation comprises betaine HCl, plant enzymes, papain, probiotic micro flora, fruitooligosaccharides, l-glutamine, quercitin, butyric acid, borage seed, flax seed, lecithin, gamma oryzanol, bromelain, pepsin, and N-acetylglucosamine.Type: GrantFiled: December 1, 1998Date of Patent: July 30, 2002Assignee: Renew Life, Inc.Inventors: Travis L. Terry, Tommy Stanley Watson, Brenda F. Watson
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Publication number: 20020098175Abstract: Food composition in the form of a flour comprising at least 50% of protein, less than 15% of carbohydrates and 35 to 50% of plant fibers; preferably the carbohydrate content is less than 10%, advantageously less than 5%; this composition may be used as a substitute for wheat flour in the preparation of foods such as pasta, bread, bread sticks, bakery products and pastries and constitutes the basis of a method for improving the appearance of a person by achieving a loss of weight which is beneficial from the aesthetic point of view.Type: ApplicationFiled: October 18, 2001Publication date: July 25, 2002Inventor: Mathias C. Zohoungbogbo
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Publication number: 20020076438Abstract: A high drug load spheronized beadlet is provided wherein said beadlet comprises about 80% to 100% by weight of an acid labile medicament, preferably didanosine, about 0% to about 10% by weight of a disintegrant, and about 0% to about 10% by weight of a binder selected from the group consisting of sodium carboxymethylcellulose, hydroxypropylmethylcellulose, potassium alginate, and partially pregelatinized corn starch. A high drug load pharmaceutical composition, comprising the beadlet, with an enteric coating disposed thereon, is also provided.Type: ApplicationFiled: November 16, 2001Publication date: June 20, 2002Inventors: Ismat Ullah, Gary J. Wiley
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Publication number: 20020061302Abstract: The use of physiologically acceptable enzyme mixtures having lipolytic, proteolytica and amylolytic activity, of microbial or animal origin, preferably digestive enzyme mixtures such as pancreatin or digestive enzyme mixtures containing pancreatin, for the treatment of diabetes. The invention also relates to the production of pharmaceutical compositions suitable for such treatment. A preferred variant of the invention relates to use of this enzyme mixture having lipolytic, proteolytic and amylolytic activity, especially digestive enzyme mixtures such as pancreatin or digestive enzyme mixtures containing pancreatin, for the adjuvant treatment of type I or type II diabetes mellitus.Type: ApplicationFiled: September 17, 2001Publication date: May 23, 2002Inventors: Suntje Sander-Struckmeier, Claus Rudolf Steinborn, Martin A. Rudmann, Diethard Schwanitz, Friederike Henniges
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Patent number: 6375948Abstract: The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.Type: GrantFiled: July 11, 2000Date of Patent: April 23, 2002Assignee: Kao CorporationInventors: Naoko Tsuji, Shigeru Moriwaki, Atsushi Ohuchi, Yasuto Suzuki
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Patent number: 6177072Abstract: Soy hydrolysate compositions are produced by a process utilizing multiple enzymes. The soy hydrolysate compositions provide insect attractant and repellent properties. Methods of using the soy hydrolysate compositions for insect control are also disclosed.Type: GrantFiled: June 10, 1998Date of Patent: January 23, 2001Inventors: Sadik Tuzun, Ismail Alp