Oxidoreductases (1. ) (e.g., Catalase, Dehydrogenases, Reductases, Etc.) Patents (Class 424/94.4)
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Publication number: 20140377332Abstract: Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.Type: ApplicationFiled: November 21, 2013Publication date: December 25, 2014Inventors: Florian N. Ludwig, Stephen D. Pacetti, Syed F.A. Hossainy, Dariush Davalian
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Publication number: 20140370072Abstract: Provided herein is a prohealing piezoelectric coating and the method of making and using the same.Type: ApplicationFiled: September 3, 2014Publication date: December 18, 2014Inventors: Syed Faiyaz Ahmed Hossainy, Mikael Trollsas, Lothar Walter Kleiner
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Publication number: 20140363414Abstract: A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.Type: ApplicationFiled: August 18, 2014Publication date: December 11, 2014Applicants: Mountain View Pharmaceuticals, Inc., Duke UniversityInventors: Merry R. SHERMAN, Mark G.P. Saifer, L. David Williams, Michael S. Hershfield, Susan J. Kelly
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Patent number: 8900575Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing enzymes embedded in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions including, but not limited to, hyperoxaluria, absorptive hyperoxaluria, enteric hyperoxaluria, primary hyperoxaluria, idiopathic calcium oxalate kidney stone disease (urolithiasis), vulvodynia, oxalosis associated with end-stage renal disease, cardiac conductance disorders, inflammatory bowel disease, Crohn's disease, ulcerative colitis, and patients who have undergone gastrointestinal surgery and bariatric surgery (surgery for obesity), and/or who have undergone antibiotic treatment.Type: GrantFiled: December 15, 2006Date of Patent: December 2, 2014Assignee: Oxthera Intellectual Property ABInventors: Qingshan Li, Harmeet Sidhu
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Publication number: 20140348812Abstract: The present invention relates generally to the field of obesity and complications arising therefrom and in particular to the control of obesity by inhibiting adipogenesis and related processes.Type: ApplicationFiled: August 6, 2014Publication date: November 27, 2014Inventors: Antonio RAJIC, Dominic J. AUTELITANO, Ana K. VRKIC, Christopher G. HOSKING, Leodevico L. ILAG
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Patent number: 8889188Abstract: This invention involves two fields of photoelectron information materials and pharmaceuticals, especially refers to the self-assembly of conducting photoluminescence nanomedicine crystals and thin films and their preparation processes. In the invention, self-assembling unitary, binary, ternary and quaternary complexes of an antioxidase antioxidant, an agonist of the ?-adrenergic receptors, an agonist of the P2-purinergic receptors and an antagonist of benzalkonium-typed calcium channels is to employ an interaction of inelastic electron tunneling, which possesses photoelectron properties of inelastic electron tunneling and photoluminescence with the central wavelength ˜500 nm and the wavelength wide ˜200 nm in the size-controlled square or cubic geometrical complexes. The invention is not only beneficial for drug discovery targeted disease mechanisms, but also profitable for inventions of photoelectron sensing new materials.Type: GrantFiled: December 29, 2005Date of Patent: November 18, 2014Assignee: Zhongshan Hospital, Fudan UniversityInventor: Yan Fang
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Publication number: 20140335067Abstract: A method for treating a disease, particularly asthma and anaphylactic shock, comprises administering to a subject in need thereof an effective amount of an EC-SOD protein or a vector having a polynucleotide encoding thereof.Type: ApplicationFiled: July 7, 2014Publication date: November 13, 2014Inventors: Dong Heon SHIN, Tae Yoon Kim
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Publication number: 20140335155Abstract: The present invention provides a composition for improving skin conditions, containing the extracellular domain of human bone morphogenetic protein receptor 1a as an active ingredient. The present invention contains the extracellular domain of human bone morphogenetic protein receptor 1a as an active ingredient inside a nanoliposome comprising hydrogenated lecithin as a constituent component, and the particle size is 50-250 nm. The composition of the present invention reduces wrinkles and alleviates atopic dermatitis. In addition, the present invention provides a method for improving skin conditions, comprising the step of administering a composition containing the extracellular domain of human bone morphogenetic protein receptor 1a as an active ingredient to a subject.Type: ApplicationFiled: August 30, 2012Publication date: November 13, 2014Applicant: JOINT CENTER FOR BIOSCEINCESInventors: Zung Yoon Yang, Byung Hak Yoon, Seung-Hyon Choi
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Publication number: 20140335069Abstract: Aspects of embodiments may include methods for automated enzymatic detection of glucose-6-phosphate dehydrogenase (G6PD) activity. Aspects of embodiments may include methods for enzymatic detection of G6PD activity in droplets in oil. Aspects of embodiments may include a system including a droplet actuator. Aspects of embodiments may include a treatment method.Type: ApplicationFiled: November 20, 2012Publication date: November 13, 2014Applicant: ADVANCED LIQUID LOGIC, INC.Inventors: Carrie A. Graham, Allen E. Eckhardt
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Publication number: 20140335068Abstract: A method for treating an angiogenesis-mediated eye disease, includes administering to a subject in need thereof an effective amount of EC-SOD protein, or a vector having a polynucleotide encoding the EC-SOD protein, to treat angiogenesis-mediated eye diseases.Type: ApplicationFiled: July 7, 2014Publication date: November 13, 2014Inventors: Dong Heon SHIN, Tae Yoon Kim
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Patent number: 8883142Abstract: A reagent measuring a glycated protein, comprising a protease and a protein of any one of [1] to [4] below: [1] a protein comprising the amino acid sequence represented by SEQ ID NO:1; [2] a protein comprising an amino acid sequence with one to ten amino acid deletions, substitutions, or additions in the amino acid sequence represented by SEQ ID NO:1, and having fructosyl peptide oxidase activity; [3] a protein comprising an amino acid sequence having 99% or higher homology to the amino acid sequence represented by SEQ ID NO:1, and having fructosyl peptide oxidase activity; and [4] a protein having fructosyl peptide oxidase activity, which is encoded by an expression plasmid harbored by the Escherichia coli XL1-Blue MRF? strain deposited under Accession No. FERM BP-11026.Type: GrantFiled: May 1, 2014Date of Patent: November 11, 2014Assignee: Kyowa Medex Co., Ltd.Inventors: Kazuo Aisaka, Keiko Suzuki
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Patent number: 8883137Abstract: A nutritional composition comprising by weight: between 0.05 and 30% selenium-enriched yeast; between 1 and 90% yeast beta-glucan; between 0.5 and 60% Vitamin C; and between 0.5 and 40% Vitamin E. The composition features anti-oxidative, anti-aging, cancer-preventing, and immune-stimulating properties.Type: GrantFiled: November 4, 2008Date of Patent: November 11, 2014Assignee: Angel Yeast Co., Ltd.Inventors: Xuefeng Yu, Zhihong Li, Minghua Yu, Juan Yao, Yan Zhang, Yamin Zhu
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Publication number: 20140328821Abstract: The present invention relates to nucleic acids coding for and capable of expressing a rod-derived cone viability factor (RdCVF) and viral vectors containing these nucleic acids. The invention also relates to compositions and pharmaceutical preparations comprising these nucleic acids or vectors, methods of producing or secreting an RdCVF, and methods of treatment.Type: ApplicationFiled: October 26, 2012Publication date: November 6, 2014Applicant: Wellstat Ophthalmics CorporationInventor: Tianci Luo
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Publication number: 20140322308Abstract: The invention discloses a pharmaceutical composition comprising recombinant human superoxide dismutase (rhS-OD) for preventing or treating one or more adverse reactions caused by treatment with an EGFR inhibitor in a subject.Type: ApplicationFiled: December 6, 2012Publication date: October 30, 2014Inventors: Hans Loibner, Harald Schnidar
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Publication number: 20140314733Abstract: Composition for the removal of biofilms present on a substrate, comprising at least one detergent component comprising at least one sequestering agent and at least one agent that is simultaneously a wetting and a dispersing agent, and at least one enzymatic component containing at least one protease, at least one laccase and at least one polysaccharidaseType: ApplicationFiled: April 19, 2013Publication date: October 23, 2014Applicant: S.A. RealcoInventors: Gauthier Boels, Gordon Blackman, Sébastien Fastrez
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Publication number: 20140308262Abstract: The invention provides fusion protein constructs comprising a functional mitochondrial protein and methods of treating mitochondrial disorders by the fusion proteins and compositions thereof.Type: ApplicationFiled: September 23, 2013Publication date: October 16, 2014Inventor: Haya Lorberboum-Galski
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Publication number: 20140308237Abstract: The present invention relates to the use of inclusion bodies as vehicles for therapeutic protein delivery. This method is applicable to the delivery of therapeutic proteins to intracellular locations. In addition, the invention also relates to the administration of a cell or a pharmaceutical composition comprising inclusion bodies formed by therapeutic proteins. These inclusion bodies formed by therapeutic proteins could be used for the treatment of different diseases.Type: ApplicationFiled: November 15, 2013Publication date: October 16, 2014Applicants: Centro de Investigacion Biomedica en Red en Bioin- genieria, Biomateriales, y Nanomedicina (Ciber BB, Universitat Autonoma de Barcelona et al.Inventors: Elena GARCIA-FRUITOS, Esther VAZQUEZ GOMEZ, Jose Luis CORCHERO NIETO, Antonio Pedro VILLAVERDE CORRALES
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Publication number: 20140302142Abstract: According to this invention, compositions and methods for increasing the extent of penetration of a biologically active substance into the tissues and organs are proposed, the methods comprising administration of the biologically active substance in combination with one or more chaotropic agents, e.g., ammonium sulfate.Type: ApplicationFiled: April 5, 2013Publication date: October 9, 2014Inventor: Olga Klimova
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Patent number: 8852582Abstract: Compositions comprising Glutathione Reductase (GSSG-r) and Oxidized Glutathione (GSSG) or pharmaceutically acceptable salts thereof for pharmaceutical use as antiviral and antibacterial agents and for the protection against the toxicity of free radicals and in particular radicals produced by the radiolysis of cellular water are provided. Methods of making and using such compositions are also provided.Type: GrantFiled: July 29, 2011Date of Patent: October 7, 2014Inventor: Raffaele Ansovini
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Publication number: 20140286926Abstract: The present invention provides a method for reducing an allergic response and treating or preventing an allergic disease, comprising administering a subject in need thereof a therapeutically effective amount of the active ingredient for the treatment or the prevention of allergic diseases, wherein the active ingredient is glyceraldehyde-3-phosphate Dehydrogenase (G3PDH) or the functional variant or fragment thereof. The G3PDH can be isolated from Lactobacillus gasseri PM-A0005 (deposited under Budapest Treaty in the China Center for Type Culture Collection (CCTCC) with Deposit No: M 207039), as well as extract, fraction, and sub-fraction thereof.Type: ApplicationFiled: March 24, 2014Publication date: September 25, 2014Applicant: ProMD Biotech, Co., Ltd.Inventors: Wei-Chih Su, Hsiang-Ling Chen, Chun-Hsien Huang, Hsiao-Li Wu, Kuang-Chih Lee, Pei-Yu Tsai, Chun-Fu Tseng
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Patent number: 8840883Abstract: Metallo-proteins including but not limited to lactoferrin (LF), transferrin (TF) and ovotransferrin (OTF) (all members of transferrin family), ceruloplasmin (CP) and metallo-thionein (MT) were found to stabilize and enhance the bio-functional activity of tocotrienol (T3), T3 mixtures or derivates. The synergism between MP and T3 also promote the intestinal transfer and the ultimate bio-availability of T3 and T3-derivatives for physiological functions. Such functional synergism includes hypocholesterolemic, anti-thrombotic, antioxidant, anti-athermogenic, anti-inflammatory and immuno-regulatory activities of T3 agents. Addition of a non-protein-type metal chelator provided further improvement in the action of the bio-functional activity of T3. These T3 compositions are useful as pharmaceuticals, in cosmetics, in foods and as nutritional supplements.Type: GrantFiled: November 9, 2012Date of Patent: September 23, 2014Assignee: Naidu LPInventors: A. Satyanarayan Naidu, A. G. Sreus Naidu, A. G. Tezus Naidu
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Patent number: 8840877Abstract: Method for preparing an oxidized polysaccharide-protein composition, by (a) oxidizing a polysaccharide with an oxidizing agent to form an oxidized polysaccharide where less than 20% of the oxidized units are comprised of alpha-hydroxy aldehyde units, (b) reacting the oxidized polysaccharide with a protein to form a composition comprising an oxidized polysaccharide-protein conjugate, and (c) maintaining the oxidized polysaccharide-protein conjugate composition by placing it in an environment where the temperature is less than 8° C. The oxidized polysaccharide and the protein are conjugated via one or more imine bonds, the oxidized polysaccharide-protein composition is soluble in aqueous solvent, and the composition is capable of releasing the protein.Type: GrantFiled: June 26, 2009Date of Patent: September 23, 2014Assignee: Therapure Biopharma Inc.Inventors: Gord Adamson, David Bell, Steven Brookes
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Publication number: 20140271599Abstract: Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The composition contains a protein or peptide containing a thioredoxin monocysteinic active site in a reduced state and optionally further contains a reducing system.Type: ApplicationFiled: March 17, 2014Publication date: September 18, 2014Applicant: OrPro Therapeutics, Inc.Inventor: Peter B. Heifetz
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Publication number: 20140255379Abstract: This invention relates to improvements to medical devices such as biosensors containing proteins such as oxidoreductases, for example oxidase and/or peroxidase enzymes. More generally it relates to novel compositions containing proteins which are stabilised to ionising radiation.Type: ApplicationFiled: August 10, 2012Publication date: September 11, 2014Applicant: Microarray LimitedInventors: Paul Davis, Jan Jezek, Andrew Austin
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Publication number: 20140255485Abstract: The present invention relates to collagen hydrolysate and the use thereof for treating and/or preventing cellulite.Type: ApplicationFiled: May 20, 2014Publication date: September 11, 2014Applicant: GELITA AGInventors: Hans-Ulrich FRECH, Steffen OESSER, Stephan HAUSMANNS
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Publication number: 20140255362Abstract: Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.Type: ApplicationFiled: September 14, 2012Publication date: September 11, 2014Inventors: Michael Green, Guangping Gao, Manas Kumar Santra, Sanchita Bhatnagar
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Publication number: 20140248252Abstract: The present invention is directed to 4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide or a pharmaceutically acceptable salt thereof for the treatment of a disease associated with elevated blood uric acid levels, such as hyperuricemia or gout. The invention is also directed to the tosylate salt of 4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide.Type: ApplicationFiled: October 19, 2012Publication date: September 4, 2014Applicant: PFIZER LIMITEDInventors: Zahid Ali, Kenneth John Butcher, Richard Philip Butt, Stephen John Felstead, Sophie Glatt, Ruth Mitchell McKernan, Maninder Panesar
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Publication number: 20140242036Abstract: The instant invention refers to a novel process for potentiating the production of substances with antifungal activity obtained from Ganoderma lucidum, using a technological device for the differential, qualitative and quantitative expression of proteins and other bioactive molecules, selected from the group consisting of polysaccharides, triterpenoids, fatty acids and ganoderic acids. The compositions containing said substances showed antifungal activity and mycelium growth and fungi ascospore germination inhibiting activity, amongst them Mycosphaerella fijiensis, primary pathogenic agent causing black Sigatoka disease in banana and plantain crop fields.Type: ApplicationFiled: June 18, 2013Publication date: August 28, 2014Inventors: JOHN JAIRO MIRA CASTILLO, PAOLA ANDREA ZAPATA OCAMPO, LUCíA ATEHORTÚA GARCÉS, LIUDA JOHANA SEPÚLVEDA ARANGO, DIEGO FERNANDO ROJAS VAHOS
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Patent number: 8815234Abstract: A method of treatment of a human or animal body surface infection, particularly a fungal infection, comprises applying an aqueous liquid to the infected body surface, e.g. nail region, followed by applying a dressing comprising a source of hydrogen peroxide. Also provided is a combination of the liquid and dressing for use in the method.Type: GrantFiled: April 30, 2010Date of Patent: August 26, 2014Assignee: Insense LimitedInventors: Paul Davis, Andrew Austin
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Publication number: 20140234398Abstract: Some embodiments of the present invention provide pharmaceutical formulations, for treating atherosclerosis in a mammal, including a bile acid and/or a terpene atherosclerotic plaque emulsifier. Some embodiments provide methods for administering such pharmaceutical formulations. In some embodiments, pharmaceutical formulations include a combination of a bile acid and a terpene in amounts effective to result in plaque regression, and the amount of each individual emulsifier in the combination can be lower than an amount that is effective to result in plaque regression when the emulsifier is administered alone. In some embodiments, a statin can be administered simultaneously or sequentially with the pharmaceutical formulation.Type: ApplicationFiled: April 26, 2013Publication date: August 21, 2014Applicant: AtheroNova Operations, Inc.Inventor: Giorgio Zadini
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Patent number: 8802086Abstract: The present invention relates to specially selected catalase enzymes and their use in reducing hydrogen peroxide in applications, and particularly in aseptic packaging applications.Type: GrantFiled: July 1, 2013Date of Patent: August 12, 2014Assignee: Ecolab USA Inc.Inventors: Brandon L. Herdt, Joshua P. Magnuson, David D. McSherry, Junzhong Li, Krista L. Owens
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Publication number: 20140220148Abstract: The present invention relates to pharmaceutical compositions, food supplement compositions and cosmetic compositions comprising diaminooxidase, and to the use thereof.Type: ApplicationFiled: April 4, 2014Publication date: August 7, 2014Applicant: SCIOTEC DIAGNOSTIC TECHNOLOGIES GMBHInventors: Albert MISSBICHLER, Franz GABOR, Herwig REICHL
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Publication number: 20140212492Abstract: The present disclosure describes compositions for intestinal delivery of enzyme formulations and methods of treating health problems with these formulations. More specifically, the enzyme formulations include at least one histaminase and various methods of treatment of physical conditions, such as inflammation, allergy, histamine intolerance, and intestinal cancer.Type: ApplicationFiled: April 5, 2012Publication date: July 31, 2014Applicant: HISTAPHARM INC.Inventors: Mircea-Alexandru Mateescu, Carmen Calinescu, Pompilia Ispas-Szabo, Bruno Mondovi, Rodolfo Federico
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Patent number: 8790640Abstract: The teachings provided herein generally relate to site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites. More particularly, the systems taught here include a phenolic compound bound to a reactive oxygen species, wherein the phenolic compound and the reactive oxygen species react at a target area in the presence of an oxidoreductase enzyme.Type: GrantFiled: March 10, 2014Date of Patent: July 29, 2014Assignee: LiveLeaf, Inc.Inventors: Alexander L Huang, Gin Wu
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Patent number: 8778376Abstract: A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided.Type: GrantFiled: June 9, 2006Date of Patent: July 15, 2014Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Mikael Trollsas, Thierry Glauser, Yiwen Tang
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Patent number: 8778337Abstract: The use of S-adenosylmethionine (SAM) in combination with superoxide dismutase (SOD) for the preparation of medicaments for the treatment of Alzheimer's disease.Type: GrantFiled: February 25, 2009Date of Patent: July 15, 2014Assignee: Gnosis S.p.A.Inventors: Sigfrido Scarpa, Andrea Fuso, Rosellina Damiani, Mauro Rossini
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Publication number: 20140193475Abstract: The present invention provides an implantable article comprising an amorphous terpolymer and a semi-crystalline polymer. The amorphous terpolymer can be admixed with the semi-crystalline polymer or form a block copolymer with the semi-crystalline polymer.Type: ApplicationFiled: March 10, 2014Publication date: July 10, 2014Applicant: Abbott Cardiovascular Systems Inc.Inventors: Mikael Trollsas, Michael Ngo, Florencia Lim
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Patent number: 8772263Abstract: Methods and compositions for protecting muscarinic receptor(s) in a subject from at least one carcinogenic or toxic metal by administration of a pyrophosphate analog. Methods and compositions for preventing at least one disease induced or caused by metals compromising the function of muscarinic receptors in a subject by administration of a pyrophosphate analog. Methods and compositions for reducing toxic action of metal ions and for reducing poisoning by metals by administering a pyrophosphate analog.Type: GrantFiled: September 6, 2005Date of Patent: July 8, 2014Assignee: HealthPartners Research FoundationInventors: William H. Frey, II, John Randall Fawcett
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Patent number: 8771681Abstract: Methods and compositions for protecting and treating a muscarinic receptor in an animal or plant from bacterial, fungal, algo or algae infections through administration of at least one pyrophosphate analog.Type: GrantFiled: September 6, 2005Date of Patent: July 8, 2014Assignee: HealthPartners Research FoundationInventors: William H. Frey, II, John Randall Fawcett
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Publication number: 20140186429Abstract: The present invention provides a method of biosynthesizing a recombinant protein containing the biologically active peptide, the pharmaceutical composition containing the recombinant protein as well as the preparation of the recombinant protein. Simply speaking the consecutively multiple copies of the bioactive peptide are replaced in the amino acid sequence of a recombinant protein (so called peptide-protein). Then, a high concentration and high yield of the peptide-protein containing the consecutively multiple copies of the bioactive peptide is produced by the biosafety and edible strain of yeast without any endotoxin contamination.Type: ApplicationFiled: September 11, 2013Publication date: July 3, 2014Inventor: Hung-Chien CHIEN
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Publication number: 20140186324Abstract: This invention provides methods of isolating ferritin from plant and animal material. The isolated ferritin can be administered to humans or animals in need of iron, and can be used to treat or supplement iron deficiency. The isolated ferritin can be used in industrial applications, such as increasing the iron content in heat-processed food or beverages. The methods of the invention also include quantitation of iron derived from plant or animal ferritin.Type: ApplicationFiled: March 4, 2014Publication date: July 3, 2014Applicant: Slo-Iron, LLCInventor: Elizabeth C. Theil
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Publication number: 20140186417Abstract: An aliphatic polyester polymer for stent coating is described.Type: ApplicationFiled: February 20, 2014Publication date: July 3, 2014Applicant: Abbott Cardiovascular Systems Inc.Inventors: O. Mikael Trollsas, Lothar W. Kleiner, Syed F.A. Hossainy
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Patent number: 8765711Abstract: Methods and compositions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors, by administering pyrophosphate analogs or related compounds.Type: GrantFiled: May 17, 2011Date of Patent: July 1, 2014Assignee: HealthPartners Research FoundationInventors: William H. Frey, II, John Randall Fawcett
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Publication number: 20140178316Abstract: The present invention relates to cosmetic or dermatological compositions containing PQQ or its esters, methods of treating or promoting skin changes by topical application of these compositions, and methods of synthesis of PQQ esters. The PQQ ester-containing compositions of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the PQQ esters of the present invention have an antioxidant effect that is useful in treating a skin change.Type: ApplicationFiled: June 5, 2012Publication date: June 26, 2014Applicant: US COSMECEUTECHS, LLCInventors: Joseph Abernathy Lewis, II, Joseph C. DiNardo
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Publication number: 20140161785Abstract: Verticillin A is found to be a potent inhibitor of histone methyltransferases, selective for G9a, GLP, SUV39H1, SUV39H2, MLL1, and NSD2. Methods of using Verticillin A are provided. The Verticillin A can be synthetically produced or it can be isolated from natural sources. Methods if inhibiting one or more histone methyltransferases are provided. In addition, methods are provided for treating diseases or disorders related to overexpression of one or more histone methyltransferases. Exemplary diseases and disorders to be treated include cancer, asthma, HIV, and progeria.Type: ApplicationFiled: December 6, 2013Publication date: June 12, 2014Inventors: Feiyan Liu, Ping Wu, Kebin Liu
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Publication number: 20140154300Abstract: Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device.Type: ApplicationFiled: February 7, 2014Publication date: June 5, 2014Applicant: Abbott Cardiovascular Systems Inc.Inventors: Florian Niklas Ludwig, Stephen Pacetti, Paul Consigny
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Patent number: 8741283Abstract: What is provided is a method of treating a patient having a tumor comprising administering an effective amount of adenosine deaminase, preferably polyalkylene oxide conjugated, to a patient in need thereof.Type: GrantFiled: April 18, 2008Date of Patent: June 3, 2014Assignee: Sigma-Tau Rare Diseases, S.A.Inventors: David R. Filpula, Puja Sapra
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Publication number: 20140147430Abstract: Provided in the present invention is an application for PRDX2 and/or PRDX6 in the preparation of a pharmaceutical composition to treat or prevent damage, aging or diseases resulting from an increase in reactive oxygen species (ROS).Type: ApplicationFiled: May 23, 2012Publication date: May 29, 2014Inventor: Jianyuan Li
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Publication number: 20140141015Abstract: The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.Type: ApplicationFiled: January 31, 2014Publication date: May 22, 2014Inventors: Douglas Lake, Benjamin Katchman
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Publication number: 20140140975Abstract: The present invention generally relates to treatments involving glutaredoxins. In one aspect, systems and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, airway inflammation or asthma. In some embodiments, a glutaredoxin may be used to treat a subject. Also provided in certain aspects of the present invention are kits for therapies involving glutaredoxins, methods for promoting such therapies, and the like.Type: ApplicationFiled: November 12, 2013Publication date: May 22, 2014Applicants: Universiteit Maastricht, The University of Vermont and State Agricultural CollegeInventors: Yvonne M. Janssen-Heininger, Niki Reynaert, Vikas Anathy, Scott Aesif