Abstract: A method of coating a medical device, such as a stent is provided. The method can include forming a polymer layer containing a drug on the device, applying a polymer melt free from any solvents to the polymer layer to form a topcoat layer, wherein the during the application of the polymer melt the migration of the drug from the polymer layer is prevented or significantly minimized.
Abstract: A nanocomposite of a repeat sequence protein polymer, such as a copolymer of silk and elastin, is produced by Supercritical Antisolvent Precipitation with Enhanced Mass Transfer (SAS-EM). The nanocomposite may include an active agent, such as a protein or hormone, that is releasably bound to the repeat sequence protein polymer.
Abstract: A main object of the invention is to provide a particle for medical use which has an excellent capability of fixing a target biologically active substance and has such chemical and physical stability that the particle is less dissolved or deteriorated in a washing step. The present invention has solved the above problem with a particle for medical use having a layer containing a polymer compound formed on a surface of a core particle, wherein the polymer compound is a polymer comprising at least repeating units derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for fixing a biologically active substance, wherein the polymer has a reactive functional group on at least one terminal side thereof.
Abstract: Methods for making a balloon catheter device comprising a solvent-swellable polymer are provided. The method includes providing a balloon, wherein a wall of the balloon or a coating over the balloon comprises a polymer, wherein the polymer is swellable in an organic solvent. In certain embodiments of the invention, the polymer on the balloon is exposed to a mixture of said solvent and a therapeutic agent; and the solvent is thereafter removing, leaving the therapeutic agent in the polymer.
Abstract: A pharmaceutical formulation comprising: a core particle comprising duloxetine or its salts; a separating layer; and an enteric layer disposed over the separating layer; wherein the formulation comprises at least one amino acid, a plasticizer, or both, in at least one of the core, the separating layer, and the enteric layer.
Abstract: The invention relates to a quasi-continuously operating coating device for the coating of moulded bodies, in particular for pharmaceutical products, such as tablets, drops, pressed moldings and granulates. The coating device comprises a rotating coating drum, divided into several drum longitudinal sections by a transport element, whereby the introduction of the process medium for all segments occurs individually and depending on the appropriate stage of the coating process. The moulded bodies are conveyed through the drum in an axial direction by means of said transport element. In an ideal embodiment the transport element is in the form of a cylindrical screw.
Abstract: The present invention describes a process for the manufacture of a solid composition comprising a microorganism, which process comprises a first step of blending and/or compacting the microorganism with a salt of a medium or long-chain fatty acid to prepare a powderous mixture or compacted granulate, and a second step of providing said powderous mixture or compacted granulate with a coating. The microorganisms are preferably probiotics. The invention also relates to the solid composition obtained by said process and to its use in food.
Type:
Application
Filed:
May 18, 2006
Publication date:
August 27, 2009
Applicant:
DSM IP ASSETS B.V.
Inventors:
Chyi-Cheng Chen, Bruno H. Leuenberger, Loni Schweikert, Ernst Zedi
Abstract: The invention concerns a block copolymer of polyethylene oxide and polycaprolactone, the polyethylene oxide having a number average molecular weight from about 2.0 to about 3.8 kD, the block copolymer having a fraction of polyethylene oxide of from about 11.8 to 18.8 percent by weight. The invention also concerns polymersomes made from such copolymers and to methods of making the polymersomes.
Type:
Application
Filed:
September 28, 2006
Publication date:
August 27, 2009
Applicant:
The Trustees of the University of Pennsylvania
Inventors:
Michael J. Therien, Daniel A. Hammer, Paiman Peter Ghoroghchian, Guizhi Li
Abstract: The present invention features a method of making a coated tablet by dipping a core comprising an active agent into a coating liquid and drying said dipped core to form a outer-coating on the core, wherein the coating liquid contains at least one a starch having an amylose content of at least about 50 percent by weight of said starch.
Abstract: The invention relates to a process for manufacturing a seamless breakable capsule, comprising—co-extruding an external and hydrophilic liquid phase, and an internal and lipophilic liquid phase, in order to form a capsule constituted of a core comprising the internal and lipophilic phase, and a shell comprising the external and hydrophilic phase,—immersing into an aqueous solution containing a curing agent, wherein the external liquid phase includes a gelling agent comprising gellan gum alone or in combination with another gelling agent, a filler, and a divalent metal sequestering agent, and to breakable capsules comprising a core and a shell, wherein the shell includes a gelling agent comprising gellan gum alone or in combination with another gelling agent, a filler, and a divalent metal sequestering agent.
Type:
Application
Filed:
June 21, 2006
Publication date:
August 20, 2009
Applicant:
V MANE FILS
Inventors:
Jean-Michel Hannetel, Didier Hartmann, Nathalie Coursieres, Jean Mane
Abstract: An enteric sustained-release coated core includes a drug-containing core and a coating film. The coating film includes 20%˜80% by weight of a hydrophobic polymer and 10%˜70% by weight of an enterosoluble material. The dissolution rate of the medical component in the drug-containing core is approximately less than 10% in hydrochloric acid solution of pH 1˜3 after 2 hours. The dissolution of the medical component in the drug-containing core sustains more than 5 hours in phosphate buffer solution of pH 5˜8.
Type:
Application
Filed:
January 21, 2009
Publication date:
July 23, 2009
Applicant:
TAIWAN BIOTECH CO., LTD.
Inventors:
Min-Chuan HSU, Yu-Kao CHENG, Li-Chin LIN
Abstract: A method of manufacturing a drug delivery device includes forming a undercoat on an outer surface of a dipping mandrel, forming a tack coat on an outer surface of the undercoat, depositing granular particles on at least a portion of the tack coat, forming an overcoat on the formed tack coat, trapping the granular particles between the tack coat and the overcoat and removing an outermost portion of the overcoat to expose a portion of the granular particles. A system for treating a vascular condition includes a catheter having an inflation lumen, an elastomeric drug delivery device disposed on the catheter and in fluid communication with the inflation lumen, a plurality of expandable pores disposed within an outer layer of the elastomeric drug delivery device and at least one therapeutic agent disposed within at least a portion of the plurality of expandable pores.
Abstract: Disclosed herein is an extended release pharmaceutical formulation suitable for once daily administration, comprising a highly water soluble core consisting essentially of about 30 to about 40% by weight of venlafaxine hydrochloride, about 50 to about 80% by weight of water soluble diluent and about 2 to about 10% of water soluble binder and a coating layer having an effective combination of rate controlling polymers comprising water-soluble polymer and water insoluble, water permeable polymer.
Abstract: Multifunctional “smart” nanostructures are disclosed that include fluorescein isothiocyanate (FITC)-encapsulated SiO2 core-shell particles with a nanoscale ZnO finishing layer, wherein an outer ZnO layer is formed on the SiO2-FITC core. These ˜200 nm sized particles showed promise toward cell imaging and cellular uptake studies using the bacterium Escherichia coli and Jurkat cancer cells, respectively. The FITC encapsulated ZnO particles demonstrated excellent selectivity in preferentially killing Jurkat cancer cells with minimal toxicity to normal primary immune cells (18% and 75% viability remaining, respectively, after exposure to 60 ?g/mL) and inhibited the growth of both gram-positive and gram-negative bacteria at concentrations ?250-500 ?g/mL (for Staphylococcus aureus and Escherichia coli, respectively).
Type:
Application
Filed:
September 22, 2008
Publication date:
May 28, 2009
Applicant:
BOISE STATE UNIVERSITY
Inventors:
Hua Wang, Denise Wingett, Kevin Feris, Madhusudan R. Kongara, Alex Punnoose
Abstract: A dry suspendible enteric coating composition for suspension in water and then encasing orally ingestible articles. The dry suspendible enteric coating composition comprises a pH-dependent polymer selected from a group containing alginates and alginic acids, a pH-independent water insoluble polymer selected from the group comprising ethylcellulose and ethylcellulose-containing compositions, and a plasticizer selected from the group containing triethyl citrate, glycerin, propylene glycol, triacetin, acetylated monoglycerides, dibutyl sebacate, polyethylene glycols, sorbitals, middle chain triglycerides and combinations thereof.
Type:
Application
Filed:
November 24, 2008
Publication date:
May 28, 2009
Applicant:
VIVA PHARMACEUTICALS INC.
Inventors:
Xueju XIE, Yu-Lung (Edward) KO, Chien-Kuang (David) KO, Jason Jiang-Chung KO
Abstract: Lipoic acid pellets are described, obtained from inert cores externally coated with lipoic acid. The so obtained active cores are coated with a first layer of insulating polymeric material and then with a polymeric coat that is insoluble at the gastric pH. Pellet are then formulated pharmaceutically, for instance in jelly capsules or controlled release capsules or as oral suspensions, dispersible powders, sachets, etc.
Abstract: The present invention relates to a process for manufacturing a porous coating with structures in the micro or nano-size domain characterized by the following steps: -providing a support having a surface, -depositing on said surface one mono-layer of temporary particles, -depositing a coating on said temporary particles in such a way that the thickness of said coating is less than the particle diameter, -eliminating said temporary particles and thereby obtaining a porous coating, the pores of said coating corresponding to the spaces previously occupied by the temporary particles and at least a pail of the pores communicating with the external environment, -applying a coating fixation step, characterized by the fact that it furthermore comprise a filling step where said pores are at least partially filled with a liquid or solid substance. The invention also concerns a coating and an object which can be obtained with this process.
Type:
Application
Filed:
September 15, 2006
Publication date:
April 16, 2009
Inventors:
Heinrich Hofmann, Frederic Neftel, Laurent-Dominique Piveteau
Abstract: This invention provides a device for the controlled release of a substance and a method of controllably releasing a substance from a compartment.
Type:
Application
Filed:
April 17, 2007
Publication date:
April 16, 2009
Applicant:
KONINKLIJDE PHILIPS ELECTRONICS N.V.
Inventors:
Geert Langereis, Ventzeslav Petrov Iordanov, Michel Paul Barbara Van Bruggen, Hendrika Cecilia Krijnsen
Abstract: Water soluble, gelatin-free dip coatings for tablets and capsules comprising sucrose, glycerin and pre-gelatinized starch and/or tapioca dextrin or comprising hydroxypropyl starch, thickener, and plasticizer.
Type:
Application
Filed:
December 15, 2008
Publication date:
April 9, 2009
Inventors:
Cynthia GULIAN, Walter G. Gowan, JR., Christopher Szymczak, Michelle Papalini, Jen-Chi Chen, Frank J. Bunick
Abstract: Sheet-like dosage forms dissolving or disintegrating in an aqueous medium for releasing at least one active substance in a body orifice or body cavity. The sheet-like dosage forms comprise a polymer matrix in the form of a solidified foam containing spaces or cavities, as well as at least one pharmaceutical or cosmetic active substance. The polymer of the polymer matrix is a polyvinyl alcohol-polyethylene glycol graft copolymer. Methods for producing such dosage forms are also provided.
Abstract: A suspendible enteric coating composition for encasing orally ingestible articles wherein the enteric coating composition comprises a pH-dependent polymer selected from a group containing alginates and alginic acids, a pH-independent water insoluble polymer selected from the group comprising ethylcellulose and ethylcellulose-containing compositions, and a plasticizer selected from the group containing triethyl citrate, glycerin, propylene glycol, triacetin, acetylated monoglycerides, dibutyl sebacate, polyethylene glycols, sorbitals, middle chain triglycerides and combinations thereof.
Type:
Application
Filed:
January 24, 2008
Publication date:
March 19, 2009
Applicant:
VIVA PHARMACEUTICALS INC.
Inventors:
Xueju XIE, Edward Ko, David Ko, Jason Jiang-Chung Ho
Abstract: In one aspect, the present invention features a method of making a coated tablet, by dipping a core including an active agent into a coating liquid and drying the dipped core to form a outer-coating on said core, wherein the coating liquid includes (i) at least one copolymer of polyvinyl alcohol and polyethylene glycol, (ii) at least one gum, and (iii) a solvent for the at least one copolymer of polyvinyl alcohol and polyethylene glycol and the at least one gum and coated tablets manufactured by such method.
Abstract: According to an aspect of the present invention a method is provided which a porous medical article is contacted with a solution that contains a therapeutic agent and a solvent in order to load the pores of the medical article, after which the solvent is sublimated.
Type:
Application
Filed:
August 31, 2007
Publication date:
March 5, 2009
Applicant:
Boston Scientific Scimed, Inc.
Inventors:
David McMorrow, Anthony Malone, Tim O'Connor, Barry J. O'Brien
Abstract: This invention relates to processes for coating a substrate with a drug-containing layer in which the microstructure of the resulting dry drug reservoir layer is not a function of solvent removal.
Abstract: A method for producing an agent depot for mechanical connection to a surface of an endovascular implantable body, comprising a) providing one or more polymers; b) providing one or more agents; and c) producing an agent depot from said polymers and said agents, the agent depot being mechanically connectable to the surface of the body using force action or adhesive.
Abstract: A coating on an implant, said implant being intended for implantation in/on an implantation area, is provided. The coating comprises nitric oxide (NO) for obtaining an anti-viral, anti-fungal, and anti-bacterial effect, and for promotion of osteo-integration of the implant, bone healing, bone growth, and wound healing at said implantation area. A nitric oxide (NO) eluting polymer is integrated with a carrier material, such that said carrier material, in use, regulates and controls the elution of a therapeutic dosage of nitric oxide (NO). An implant and a kit of implants, comprising said coating are also provided. Furthermore, a manufacturing method for the implant is disclosed.
Abstract: The present invention especially relates to the use of a combination comprising (1) an ACEI selected from the group consisting of benazepril, benazeprilat, and pharmaceutically acceptable salts thereof, and (2) amlodipine or pharmaceutically acceptable salt thereof, for the manufacture a medicament for the treatment or prevention or delay of progression of a condition selected from the group consisting of hypertension, congestive heart failure, angina, myocardial infarction, artherosclerosis, diabetic nephropathy, diabetic cardiac myopathy, renal insufficiency, peripheral vascular disease, left ventricular hypertrophy, cognitive dysfunction, blood pressure-related cerebrovasular disease, stroke, pulmonary disease or pulmonary hypertension and headache; wherein (i) the amount of amlodipine or a pharmaceutically acceptable salt thereof corresponds to 6 about mg to 40 about mg of the free base and (ii) the amount of the ACE inhibitor or a pharmaceutically thereof corresponds to 20 about mg to 160 about mg o
Type:
Application
Filed:
July 28, 2008
Publication date:
November 20, 2008
Inventors:
Ann R. Comfort, William L. Daley, Santo J. Fleres, Alan E. Royce, Randy L. Webb, William S. Wei
Abstract: The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-containing fluid in a reservoir and applying focused radiation to the pathogen-containing fluid in the reservoir in a manner effective to eject a droplet of the fluid therefrom. Often, a pathogen-impermeable enclosure is used.
Abstract: Systems and methods for using the same to select one or more comparative genome hybridization (CGH) probes specific for a sub-genomic region of interest are provided. Also provided are computer program products for executing the subject methods.
Type:
Application
Filed:
March 28, 2007
Publication date:
October 2, 2008
Inventors:
Peter G. Webb, Jing Gao, B. Shane Giles, Sandra Tang
Abstract: A method of fabricating a medical implant component. The method may comprise producing a substrate from a first material in which the substrate has a bearing portion, and spraying particles of a second material by use of a thermal type spraying process onto at least the bearing portion of the substrate. The second material may be formed from a biocompatible material and a carbide source, in which the carbide source is 6.17% or more of the second material by weight. The biocompatible material may be cobalt chrome and the carbide source may be graphite. The thermal type spraying process may be a plasma spraying process or a high velocity oxygen fuel spraying process.
Type:
Application
Filed:
March 26, 2007
Publication date:
October 2, 2008
Applicant:
Howmedica Osteonics Corp.
Inventors:
Daniel E. Lawrynowicz, Aiguo Wang, Zongtao Zhang
Abstract: The present invention relates to a sublingual coated tablet and to a method for the preparation thereof. The tablet includes a core devoid of a pharmaceutically active substance, and a coating including at least one active substance. The preferred active substance is an opioid analgesic.
Type:
Application
Filed:
March 20, 2006
Publication date:
September 18, 2008
Applicant:
ETHYPHARM
Inventors:
Pascal Oury, Guillaume Benoist, Catherine Herry, Joseph Duvochel
Abstract: A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer in the solution. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.
Type:
Grant
Filed:
November 30, 2005
Date of Patent:
September 2, 2008
Assignee:
Medtronic, Inc.
Inventors:
Eric P. Berg, Ronald J. Tuch, Michael Dror, Rodney G. Wolff
Abstract: The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-containing fluid in a reservoir and applying focused radiation to the pathogen-containing fluid in the reservoir in a manner effective to eject a droplet of the fluid therefrom. Often, a pathogen-impermeable enclosure is used.
Abstract: An object of the present invention is to provide a method for easily producing coated fine particles in which core fine particles are coated with a coating layer component, etc. There are provided a method of producing coated fine particles comprising core fine particles coated with a coating layer component, comprising the steps of dispersing the core fine particles and the coating layer component(s) in a liquid and the process of coating the core fine particles with the coating layer component, wherein the liquid contains a polar organic solvent in which the coating layer component(s) is soluble, and the concentration of the polar organic solvent is such that the core fine particles is not dissolved and the coating layer component(s) can be in the dispersed state in the liquid, and the like.
Abstract: The present invention relates to stable solid dosage form and a dry process for preparing amorphous cefditoren pivoxil solid dosage forms and coating the solid dosage form with one or more layers of aqueous dispersion of film forming agents.
Abstract: Size-confined nanocomposite powders and methods for their manufacture are provided by coating fine powders with a nanoscale powder of a different composition. The nanocomposite plastics offer performance characteristics approaching those of metals and alloys. The nanocomposite powders are alternatively used for dispersion strengthening of metals, alloys, and ceramics. Materials based nanotechnology for energy devices and programmable drug delivery are included.
Abstract: The present invention relates to a method for coating of a pharmaceutical product. The method comprises the step of producing discrete droplets (7) of controlled size, shape and composition with at least one micro dispenser (1) and distributing droplets (7) with controlled velocity, time of flight. Also, the method comprises the step of controlling the production frequency and modulation of the droplets (7). Further, the method comprises the step of controlling the flow rate, temperature and composition of the carrier gas and directing droplets (7) towards particles (10) subjected to coating. The present invention also relates to a device for coating of a pharmaceutical product. The device comprises a droplet producing unit (1) and a droplet-directing unit (8). The droplet producing unit (1) is a piezo-actuated micro dispenser (1) for producing discrete droplets (7) and controlling the size, shape and composition of said droplets (7).
Type:
Grant
Filed:
July 9, 2002
Date of Patent:
February 12, 2008
Assignee:
AstraZeneca AB
Inventors:
Staffan Folestad, Ingela Niklasson Björn, Daniel Ström
Abstract: The invention relates to methods of making films having active ingredients. A film that is substantially free of active ingredient is introduced into a medium comprising an active ingredient. At least a portion of the active ingredient is transferred from the medium to the film. The films can be used in a variety of applications, including oral care, personal care, cleansing and/or home care compositions.
Type:
Application
Filed:
July 14, 2006
Publication date:
January 17, 2008
Inventors:
Thomas J. Boyd, Rensl Dillon, Jeffrey M. Miller, David B. Viscio, Abdul Gaffar
Abstract: A release coating having improved stability under aging conditions of heat and humidity is described whose release force can be altered by varying the amount of multi-lobe emulsion polymers relative to release agent.
Type:
Application
Filed:
June 6, 2007
Publication date:
December 6, 2007
Inventors:
William B. Griffith, Nader Nassif Kamel, Don Gordon Pierson
Abstract: The present invention relates to a method for preparing a hydrocolloid which may be applied to skin, particularly, wounds. The present invention comprises a first step of preparing a pre-polymer having a viscosity of 200 cps˜10,000 cps by mixing an acryl monomer and an ultraviolet initiator and irradiating on the mixture with ultraviolet rays; a second step of preparing a complex by mixing at least an ultraviolet initiator and a high water absorbing substance with the resulting pre-polymer; and a third step of polymerizing the complex with irradiating ultraviolet rays. The thus prepared hydrocolloid of the present invention has an excellent absorbency as well as self-adhesiveness, is not remained as any residue upon removing it from the skin (wound) and has less skin irritation, without employing any tackifier.
Abstract: In a method for generating polymeric wear particles for use in animal experiments as polymeric medical implant pre-clinical testing, microfabrication technique is used to design different mask patterns and obtain a uniformly sized and oriented microfabricated surface, which is used with a reciprocating wear tester to conduct an experiment on wear, so as to generate wear particles having specific size and morphology. A large quantity of wear particles could be generated within a shortened time. Separating and filtering procedures are included to produce wear particles having more uniform size, so as to meet the standards of pre-clinical test and satisfy requirements in different clinical tests. The method includes three major steps, namely, producing a microfabricated surface, conducting an experiment on wear, and collecting generated wear particles.
Abstract: An oral delivery method and composition that will facilitate the swallowing of any object such as a pill, tablet, capsule or caplet in a fast, easy, untroubled manner so as to markedly decrease the risk of the pill, caplet, capsule or tablet lodging or sticking in the mouth or the throat. It is a process that involves spraying a specially formulated mixture onto both sides of the pill or other object so that it can be more easily swallowed. The mixture includes an anti-stick and lubricating agent, a natural flavoring and other agents so that the mixture is emulsified and can be easily digested. The mixture is placed in a plastic bottle and rendered into a mist through a high viscosity handheld pump. The mist thoroughly coats the pill, providing optimum lubrication for swallowing when accompanied by drinking water or another liquid.
Abstract: Methods for imparting a dry-to-the-touch, saliva soluble, coating containing high levels of flavors and active ingredients to disposable, one-handed, dental devices comprising imparting tumbling motion to said devices and simultaneously coating said tumbling devices with multiple coatings of the dry-to-the-touch-coatings, wherein said multiple coatings comprise from between about 0.25 and about 6% by weight of said multicoated devices.
Abstract: Method of electrostatically applying powder material to a substrate, wherein the substrate is a pharmaceutical substrate and the powder material is pharmaceutically acceptable. At least some of the particles of the material comprise a core and a shell surrounding the core, and the material of the core and the shell have different physical and/or chemical properties.
Abstract: Milled nanoparticles comprising a biolgically active agent, at least one biopolymer and a coating containing at least one coating which is a polymer or ligand are produced using milling and coating techniques which have not previously been used for these applications
Type:
Application
Filed:
March 20, 2007
Publication date:
September 27, 2007
Inventors:
James W. Lillard, Rajesh Singh, Shailesh Singh
Abstract: A process for the production of animal feed additives from fermentation broth containing L-lysine is disclosed. The process does not require filtering of biomass in order to remove the biomass and produces granulated lysine of controllable lysine content with a high bulk density, low viscosity, and a low hygroscopic property which does not require the addition of an anti-absorptive substance. In this process, a lysine fermentation broth produced after slant culture, flask culture, seed process, and cultivation process is concentrated to a solid content of about 44˜52%. A product with low hygroscopicity, high bulk density, and the intended amount of contents is produced after being mixed with substances for controlling the amount of contents and granulated by coating the surface of the seeds. This process enables a production of animal feed additives having a lysine-HCl content of at least 65%, a water content of at most 3%, and a bulk density of 670±50 kg/m3.
Type:
Application
Filed:
July 31, 2006
Publication date:
July 12, 2007
Inventors:
Youn Jae Lee, Yong Bum Seo, Seung Woo Han, Jae Hun Yu, Soon Won Hong, Gyu Nam Cho, Won Seop Choi
Abstract: The present invention provides a granulation method with increased drying effect while assuring the pressure for spraying the aqueous solution and the necessary number of nozzles equivalent to those of conventional design. Specifically, the granulation method uses a granulator structured by a fluid bed which fluidizes the granulating-particles, an air feed pipe to introduce air, a nozzle for spraying the raw material aqueous solution being located at center part of the air feed pipe, and a perforated plate to feed a fluidization air to the fluid bed, thus granulating the raw material aqueous solution by spraying thereof from the nozzle into a granulation part, wherein a multi-nozzle in a specified shape having a plurality of nozzle ends thereon is used as the nozzle for spraying the raw material aqueous solution.
Abstract: The present invention relates to heterofunctional copolymers of glycerol and polyethylene glycol, conjugates of these heterofunctional copolymers with bioactive agents, nanoparticles, hydrophobic polymers and/or lipids; and to compositions containing these conjugates.
Abstract: A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.
Type:
Grant
Filed:
July 18, 2002
Date of Patent:
February 13, 2007
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Wouter E. Roorda, Syed F. A. Hossainy, Ni Ding, Fuh-Wei Tang, Stephen D. Pacetti
Abstract: The method of the present invention is for coating an implant device. The implant device is coated with a protein film, such as fibrinogen. A first bisphosphonate substance, such as pamidronate, is immobilized to the protein film. A second bisphosphonate substance, such ibandronate, is adsorbed to the first bisphosphonate wherein the first bisphosphonate is different from the second bisphosphonate.
Type:
Grant
Filed:
July 1, 2004
Date of Patent:
January 16, 2007
Assignee:
Optovent AB
Inventors:
Per Vilhelm Aspenberg, Pentti Olavi Tengvall