Liquid Conveying (e.g., Vascular, Arterial, Bile Duct, Urethra) Patents (Class 427/2.25)
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Publication number: 20120009325Abstract: A stent including hollow struts is formed on a cylindrical substrate. The struts of the stent are formed by electroforming metal layers of the strut in openings formed in a patterned photoresist material. A first metal layer forming the inner strut material is formed in openings in a first photoresist material. A sacrificial material to form the cavity to make the struts hollow is formed in openings in a second photoresist material. A second metal layer forming the side walls and outer wall of the struts is formed in openings in a third photoresist material and around the sacrificial material. The photoresist materials are removed. The substrate and cavity sacrificial material are removed, leaving hollow struts formed into a stent pattern. The hollow struts may be filled with a therapeutic substance for elution. Openings through the struts to the cavity may be formed during the forming process.Type: ApplicationFiled: July 12, 2010Publication date: January 12, 2012Applicant: Medtronic Vascular, Inc.Inventor: Christopher Storment
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Patent number: 8088060Abstract: A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is provided with a coating with a pharmaceutical composition containing a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises one or more barrier layers, and a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.Type: GrantFiled: November 15, 2006Date of Patent: January 3, 2012Assignee: OrbusNeich Medical, Inc.Inventors: Robert John Cottone, Jr., Margaret Yoklavich, Sherry Parker
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Patent number: 8084076Abstract: A process for depositing an active substance on selected regions of the surface of a stent, comprising: (i) providing the active substance in at least one form selected from the group consisting of a powder and a paste; and (ii) depositing the active substance on the selected regions of the surface of the stent. Preferably, the active substance comprises or consists essentially of FK506, such as FK506 in the form of a powder with a grain size smaller than 15 micron or a paste with a base of FK506 with a viscosity not lower than 100,000 to 120,000 cps.Type: GrantFiled: February 7, 2008Date of Patent: December 27, 2011Assignee: Sorin Biomedica Cardio S.R.L.Inventors: Andrea Grignani, Maria Curcio, Vincenzo Cassolaro
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Patent number: 8084077Abstract: A one step method for drug coating an interventional device is disclosed by mixing a drug with a phosphorylcholine-linked methacrylate polymer in a liquid and applying the mixture to an interventional device, such as a stent, in a single step.Type: GrantFiled: May 25, 2007Date of Patent: December 27, 2011Assignee: Abbott LaboratoriesInventors: Peter J. Tarcha, David Pecosky
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Publication number: 20110311713Abstract: A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to an ultrasonic material delivery apparatus. The implantable device is rotated at a relative speed. The relative speed may be more than 120 revolutions per minute. An application material is applied to the implantable device using the ultrasonic material delivery apparatus. The relative speed may be sufficient to reduce the size of at least a portion of droplets of the application material. A system for rotating an implantable device is disclosed. The system includes an implantable device and a rotation system configured to rotate the implantable device. A longitudinal axis of the implantable device and a longitudinal axis of a rotation member of the rotation system may be offset a desired dimension. An inside diameter of the implantable device may be larger than an outside diameter of a rotation member.Type: ApplicationFiled: June 17, 2010Publication date: December 22, 2011Applicant: ABBOTT CARDIOVASCULAR SYSTEMS, INC.Inventors: David O'Neill, Matthew Coates
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Publication number: 20110311605Abstract: Provided herein are coating designs for the tailored release of two therapeutic agents from polymer coatings and methods of making and using the same.Type: ApplicationFiled: June 27, 2011Publication date: December 22, 2011Applicant: Abbott Cardiovascular Systems Inc.Inventor: Stephen D. Pacetti
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Publication number: 20110311714Abstract: Arrangements are provided for assembling multiple substrates for coating within a fluidized bed coater so as to deposit a coating of uniform thickness across the entire exterior surface thereof. One embodiment includes a method for coating orthopedic implants having convex and concave surfaces with pyrocarbon by pyrolytic decomposition of a hydrocarbon.Type: ApplicationFiled: February 22, 2011Publication date: December 22, 2011Inventors: Mark E. Seeley, Fletcher Derek Southard, Mike James Mewhort, Joseph Earl Robinson, Roger William Leikam, Jeff Wayne Stark, Brett A. Bickerton, Jonathan C. Stupka, David Wilde, Cephas M. Wozencraft
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Publication number: 20110305819Abstract: A method of coating a stent involves modifying a spray coating parameter until a target mass per coating layer is achieved. A method for coating involves spraying a batch of stents according to spraying parameters that were previously determined to provide a target mass per coating layer.Type: ApplicationFiled: August 22, 2011Publication date: December 15, 2011Applicant: Abbott Cardiovascular Systems Inc.Inventors: Kevin Jow, Daniel A. Castro
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Patent number: 8075940Abstract: A method for coating bioactive material and a structured coated with a bioactive material are disclosed. The bioactive material coating method includes: flowing a coating solution, produced as a bioactive material is dissolved in a mixed solvent, inside a structure having a lumen; and coating the bioactive material on at least one of inner and outer surfaces of the structure, with different concentrations. The mixed solvent is mixed with two or more solvents having different features. The occurrence of the strangulation of blood vessels and inflammation can be reduced. An increase in the size of the myofibroblast is not suppressed. The coating solution is produced as a medication is dissolved in a mixed solvent, where the mixed solvent is produced as a polar solvent and a nonpolar solvent are mixed with each other at a certain ratio.Type: GrantFiled: January 19, 2009Date of Patent: December 13, 2011Assignees: Sungkyunkwan University Foundation for Corporate Collaboration, Samsung Life Welfare FoundationInventors: Dae-Joong Kim, In-Su Baek, Jong-Sang Park, Hye-Yeong Nam, Chengzhe Bai
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Publication number: 20110301696Abstract: This application is directed to a device comprising a covering attached to the device. A process of making a device with a specific covering attached is also disclosed. The application further discloses a method for the treatment of perforations, fistulas, ruptures, dehiscence and aneurisms in luminal vessels and organs of a subject.Type: ApplicationFiled: May 31, 2011Publication date: December 8, 2011Inventor: Eric K. Mangiardi
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Patent number: 8071155Abstract: Medical devices, such as stents, and methods of making the devices are disclosed. In some embodiments, a method includes diffusing a first element into a first portion of the medical device. The first element includes carbon, hydrogen, nitrogen, oxygen, or combinations thereof. The first portion includes a refractory material.Type: GrantFiled: May 5, 2005Date of Patent: December 6, 2011Assignee: Boston Scientific SciMed, Inc.Inventor: Torsten Scheuermann
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Patent number: 8067054Abstract: A method of making a drug eluting stent comprises forming a porous stent body surface layer by ion implantation, applying a layer of ceramic particles on the porous layer and compressing the layer of ceramic particles. The layer of ceramic particles can be compressed to successively higher densities. Drugs can be loaded into the layer of ceramic materials at a relatively low density before the layer of ceramic materials is compressed to a higher density to achieve a desired low drug release rate.Type: GrantFiled: April 5, 2007Date of Patent: November 29, 2011Assignee: Boston Scientific Scimed, Inc.Inventor: Jan Weber
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Patent number: 8067055Abstract: A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.Type: GrantFiled: March 23, 2007Date of Patent: November 29, 2011Assignee: Biosensors International Group, Ltd.Inventors: Douglas R. Savage, John E. Shulze, Ronald E. Betts, Sepehr Fariabi, Shih-Horng Su
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Publication number: 20110282436Abstract: A stent includes a MOF which adjusts pore size upon desorption or adsorption of organic molecules.Type: ApplicationFiled: May 12, 2011Publication date: November 17, 2011Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Mourad Rahi, Liliana Atanasoska, Rajesh Radhakrishnan, Robert W. Warner, Barry Cool
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Patent number: 8057844Abstract: Methods for coating an implantable medical device, such as a stent, are provided.Type: GrantFiled: May 27, 2009Date of Patent: November 15, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Yung-Ming Chen, Henjen Ho
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Patent number: 8057535Abstract: The invention provides an implantable medical device comprising a fibrous polymer body comprising a plurality of electrospun poly(urethane) fibers, a support filament wrapped around the body, an outer layer around the filament for adhering the filament to the body, the outer layer comprising a plurality of electrospun poly(urethane) fibers, and a polymer primer coating at least the fibers of the body. The polymer primer comprises poly(lactide) and is attached to a heparin residue through a link.Type: GrantFiled: March 22, 2011Date of Patent: November 15, 2011Assignee: Nano Vasc, Inc.Inventors: Craig Hashi, Daniel Francis Davidson
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Publication number: 20110274823Abstract: Methods and devices for the provision of a coating on an implantable medical device. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The methods and devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.Type: ApplicationFiled: July 18, 2011Publication date: November 10, 2011Inventors: Roger Labrecque, Geoffrey Moodie, Joseph Ferraro, Lisa Rogers, Paul Martakos, Theodore Karwoski, Steve A. Herweck, Suzanne Conroy, Brian Sunter, Georgette Henrich
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Publication number: 20110274821Abstract: The invention includes a medical hydrogel made from polymerized polysaccharide macromers. The macromers are preferably polysaccharides decorated with polymerizable groups, for example, methacrylates. The macromers may also be made into polymers of at least two macromers polymerized together. These polymers are preferably multi-armed or high-molecular weight and used for medical uses, for example, making coatings on medical devices. Macromers of N-vinylpyrrolidone are also disclosed herein.Type: ApplicationFiled: July 15, 2011Publication date: November 10, 2011Inventors: Ajay K. Luthra, Shivpal S. Sandhu, John O. Hudson
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Publication number: 20110274822Abstract: Various embodiments of methods and devices for coating stents are described herein.Type: ApplicationFiled: July 18, 2011Publication date: November 10, 2011Inventor: Jason Van Sciver
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Patent number: 8053030Abstract: This invention relates to methods of applying to a substrate a hydrophilic coating that becomes lubricious when activated with water or water vapor, and to substrates having such a hydrophilic coating.Type: GrantFiled: January 30, 2007Date of Patent: November 8, 2011Assignee: Hollister IncorporatedInventor: Thomas H. Gilman
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Patent number: 8053020Abstract: Methods are provided for coating a first surface of a device while also preventing coating of a second surface of the device by forming a covering of solid carbon dioxide on the second surface. In one embodiment of the invention, a method is provided for coating a luminal surface of a device while masking the abluminal surface with a covering of solid carbon dioxide. In another embodiment, a method is provided for coating the abluminal surface of the device while covering the luminal surface of the device with solid carbon dioxide.Type: GrantFiled: February 26, 2009Date of Patent: November 8, 2011Assignee: Cook Medical Technologies LLCInventor: William F. Moore
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Patent number: 8053019Abstract: A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The method includes subjecting the coating to a thermal condition such as a temperature above the glass transition temperature of a polymer included in the coating.Type: GrantFiled: February 3, 2010Date of Patent: November 8, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Fuh-Wei Tang, Stephen D. Pacetti, Jeff Royal, Dorie M. Happ, Kurt Scheinpflug, Ty Hu
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Patent number: 8052912Abstract: This disclosure describes a method for crimping a polymeric stent onto a catheter for percutaneous transluminal coronary angioplasty or other intraluminal interventions. The method comprises crimping the stent onto a catheter when the polymer is at a target temperature other than ambient temperature. The polymer can optionally comprise drug(s).Type: GrantFiled: October 1, 2004Date of Patent: November 8, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventors: David C. Gale, Bin Huang, Anthony Abbate, Stephen D. Pacetti
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Publication number: 20110264190Abstract: Provided herein are devices comprising a stent; and a coating on said stent comprising a polymer and an active agent, wherein the active agent comprises at least one of: extracellular matrix and an extracellular matrix component. Provided herein are methods of preparing a device comprising a stent and a coating on said stent; said method comprising: providing a stent; and forming a plurality of layers on said stent; wherein the coating comprises a polymer and at least one of said layers comprises one or more active agents; wherein at least a portion of the active agent comprises at least one of extracellular matrix and an extracellular matrix component.Type: ApplicationFiled: April 20, 2011Publication date: October 27, 2011Applicant: MICELL TECHNOLOGIES, INC.Inventors: James B. McClain, Arthur J. Benvenuto
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Publication number: 20110262621Abstract: A beneficial agent can be loaded as discrete droplets on a prosthesis, such as a stent. Relative movement between the prosthesis and a dispensing element can be controlled to define a dispensing path in a raster format. The discrete droplets can be dispensed from a dispensing element when the dispensing element is detected to be in alignment with a cavity formed in the prosthesis such that the discrete droplets are deposited in the cavity. The discrete droplets can be dispensed from a dispensing element when the dispensing element is detected to be in alignment with a structural element of the prosthesis such that the discrete droplets are deposited on the structural element.Type: ApplicationFiled: July 5, 2011Publication date: October 27, 2011Inventors: Donald VERLEE, Peter Tarcha, Keith Cromack, Richard Quint
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Patent number: 8043651Abstract: A method and device for coating a medical device, such as a stent, including rolling the stent against a ribbon or gravure roll impregnated with coating material. The ribbon and gravure roll may include a recessed pattern matching a strut pattern of the stent. The stent may also be rolled against a plate or cylinder while coating material is forced onto the stent through a pattern of holes or openings in the plate or cylinder matching a strut pattern of the stent.Type: GrantFiled: October 22, 2007Date of Patent: October 25, 2011Assignee: Boston Scientific Scimed, Inc.Inventors: Tim O'Connor, LiJuan He, Aiden Flanagan, Anthony Malone, Barry Heaney, Dave McMorrow
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Patent number: 8043367Abstract: Implantable medical devices fabricated at least in part of a polymer-bioceramic composite having bioceramic particles with radiopaque functional groups grafted to a surface of the bioceramic particles are disclosed. Implantable medical devices fabricated at least in part of a radiopaque material having bioceramic particles with polymer chains grafted onto a surface of the bioceramic particles, the radiopaque functional groups being chemically bonded to the grafted polymer chains, are disclosed.Type: GrantFiled: March 24, 2011Date of Patent: October 25, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventor: Yunbing Wang
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Publication number: 20110245908Abstract: An apparatus and method for applying a coating composition to a stent. A mandrel for supporting the stent has one or more drive pins and other supporting structure that loosely supports the stent, in an unstable position. The support permits freedom of movement of the stent relative to the mandrel to cause the stent to frequently re-position itself over the mandrel during a spraying process. When a coating composition is applied, the stent randomly or periodically moves about relative to the mandrel due to intermittent contact between the stent and the rotating mandrel and fluidic forces applied through the sprayed coating composition.Type: ApplicationFiled: April 1, 2010Publication date: October 6, 2011Applicant: Abbott Cardiovascular Systems Inc.Inventor: John E. Papp
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Publication number: 20110244017Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.Type: ApplicationFiled: March 31, 2010Publication date: October 6, 2011Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: Lothar W. Kleiner, Syed F.A. Hossainy, Mikael Trollsas, Stephen D. Pacetti
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Publication number: 20110244112Abstract: A stent is coated by ejecting droplets of a coating substance from a reservoir containing a coating substance. A reservoir housing can have a plurality of reservoir compartments. A transducer is used to eject the coating substance from the reservoir. Energy from the transducer is focused at a meniscus or an interface between the coating substance and another coating substance in the reservoir.Type: ApplicationFiled: June 17, 2011Publication date: October 6, 2011Applicant: Abbott Cardiovascular Systems Inc.Inventors: Jason Van Sciver, Yung-Ming Chen, Lothar Kleiner
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Publication number: 20110238161Abstract: This disclosure describes the application of a supplemental corona source to provide surface charge on submicrometer particles to enhance collection efficiency and micro-structural density during electrostatic collection.Type: ApplicationFiled: March 26, 2010Publication date: September 29, 2011Applicants: BATTELLE MEMORIAL INSTITUTE, MICELL TECHNOLOGIESInventors: John L. Fulton, George S. Deverman, Dean W. Matson, Clement R. Yonker, C. Douglas Taylor, James B. McClain, Joseph M. Crowley
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Publication number: 20110238163Abstract: There is provided a device comprising a body structure having one or more surfaces wherein at least one of the surfaces comprises a pH sensitive layer comprising a linear polymer, wherein the water solubility of the linear polymer increases from a first water solubility to a second water solubility at a pH trigger. A method of forming a device, and a method of preventing or mitigating infection is also described.Type: ApplicationFiled: March 8, 2011Publication date: September 29, 2011Applicant: LABORATORIOS FARMACEUTICOS ROVI S.A.Inventors: GAVIN Paul ANDREWS, DAVID Simon JONES, SEAN Patrick GORMAN
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Patent number: 8025916Abstract: A composite stent and a method for making the same are provided.Type: GrantFiled: December 18, 2006Date of Patent: September 27, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventors: Syed F. A. Hossainy, Orlando Padilla, Daryush Mirzaee, Fuh-Wei Tang
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Publication number: 20110229627Abstract: Electrospray methods and systems for coating of objects (e.g., medical devices such as a stent structure) with selected types of coatings (e.g.Type: ApplicationFiled: May 27, 2011Publication date: September 22, 2011Applicants: NANOCOPOEIA, INC., Regents of the University of MinnesotaInventors: ROBERT A. HOERR, JOHN V. CARLSON, DA-REN CHEN, DAVID Y.H. PUI
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Publication number: 20110217450Abstract: A method for coating a stent can involve a device having a drying zone, a spray zone, and movable member for positioning a stent in the drying zone and another stent in the spray zone. Each stent can be on a support. A force can be applied to the outside surface of a stent to prevent rotation of the stent with respect to the support.Type: ApplicationFiled: February 28, 2011Publication date: September 8, 2011Inventors: Bryan Russell Hemphill, Andrew James McKay, Sang joon Park, Aaron Meyer Waese, Anthony S. Andreacchi, Yung-Ming Chen, Arnoldo M. Currlin, Antonio Garcia, Jason Van Sciver
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Publication number: 20110212152Abstract: Methods for making modified surfaces and in particular, surfaces that may be lubricious and may be further treated to be anti-microbial are disclosed. Devices comprising modified surfaces prepared by the methods are also disclosed. An exemplary method comprises incubating a photo-initiator-coated substrate in an aqueous monomer solution that is capable of free radical polymerization, exposing the incubating substrate to ultraviolet (UV) light creating a modified surface on the substrate. An anti-microbial agent may be added to the modified surface.Type: ApplicationFiled: December 30, 2010Publication date: September 1, 2011Inventors: Valerio Ditizio, Frank DiCosmo
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Patent number: 8007854Abstract: A ceramic coating with gradient density/porosity and/or incorporated biologically active agents can be fabricated on the surface of substrates, including the surface of implantable medical devices.Type: GrantFiled: January 4, 2007Date of Patent: August 30, 2011Assignee: The University of ConnecticutInventors: Mei Wei, Haibo Qu, Xiaohua Yu
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Patent number: 8007858Abstract: A method and system of coating an implantable device, such as a stent, are provided.Type: GrantFiled: January 30, 2009Date of Patent: August 30, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Stephen D. Pacetti, Wouter E. Roorda, Ni Ding
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Patent number: 8007857Abstract: Methods for controlling the release rate and improving the mechanical properties of a stent coating are disclosed.Type: GrantFiled: September 7, 2007Date of Patent: August 30, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventor: Syed Faiyaz Ahmed Hossainy
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Patent number: 8007855Abstract: A method of coating an implantable medical device is disclosed, the method includes applying a composition onto the device and drying the composition at elevated temperature in an environment having increased relative humidity.Type: GrantFiled: July 5, 2007Date of Patent: August 30, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Stephen Pacetti
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Patent number: 8007856Abstract: A mounting assembly for a stent and a method of coating a stent using the assembly are provided.Type: GrantFiled: October 26, 2009Date of Patent: August 30, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Charles Snyder, Anh Tran, Arthur J. Wen
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Publication number: 20110206754Abstract: The present description relates to an implant device, having an improved integration in the tissue of the animal or human body into which it is inserted, when compared to the prior art devices. Particularly, the present description relates to an implant device for the implant in animal or human body, comprising a hyaluronic acid coating, characterized in that said hyaluronic acid is low molecular weight hyaluronic acid or is composed of a mixture of low molecular weight hyaluronic acid and high molecular weight hyaluronic acid, wherein said low molecular weight hyaluronic acid has a molecular weight lower than 80,000 Dalton and said high molecular weight hyaluronic acid has a molecular weight higher than 700,000 Dalton.Type: ApplicationFiled: October 12, 2009Publication date: August 25, 2011Inventors: Marco Morra, Clara Cassinelli, Giovanna Cascardo, Daniele Bollati
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Patent number: 8003156Abstract: Various embodiments of methods and devices for coating stents are described herein.Type: GrantFiled: May 4, 2006Date of Patent: August 23, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Jason Van Sciver
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Patent number: 8003158Abstract: Various embodiments of methods for coating stents are described herein. One method is directed to a stent spraying apparatus calibration procedure. Another method is directed to obtaining a batch of stents where each stent has the same number of layers of coatings, and the same total amount of coating material.Type: GrantFiled: September 28, 2007Date of Patent: August 23, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventors: Kevin Jow, Daniel A. Castro
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Patent number: 8003157Abstract: A system for coating a stent includes a device for weighing a stent, a device for aligning the stent with a stent support, a device for coating the stent, a device for drying the stent, and a device for inspecting the stent.Type: GrantFiled: June 15, 2007Date of Patent: August 23, 2011Assignees: Abbott Cardiovascular Systems Inc., ATS Automation Tooling Systems Inc.Inventors: Anthony S. Andreacchi, Yung-Ming Chen, Arnoldo M. Currlin, Antonio Garcia, Jason Van Sciver, Bryan D. Glenn
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Publication number: 20110200660Abstract: A method of forming a coating on a medical device having a controlled morphology is described. A medical device having a controlled morphology is described.Type: ApplicationFiled: February 28, 2011Publication date: August 18, 2011Applicant: Advanced Cardiovascular Systems, Inc.Inventors: Lothar Walter Kleiner, Jessica ReneƩ DesNoyer, Stephen Dirk Pacetti, Syed Faiyaz Ahmed Hossainy
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Publication number: 20110202125Abstract: An artificial stent and its preparation method. The artificial stent comprises a stent body and a coating on it. The artificial stent is characterized in that the coating comprises a drug-loaded layer containing silk fibroin and a drug. The drug-loaded layer has a microporous structure substantially consists of silk fibroin and loaded with the drug. The microporous structure is obtained by a method comprising: uniformly coating the surface of the stent body with a solution of silk fibroin, denaturing by heat or chemical reagents; soaking the stent with purified water; then freeze drying and warming-drying, so as to from a microporous structure of the coating; loading the drug into the micropores in the coating; and removing the stent and drying. Silk fibroin used to coat the stent is a natural bio-material with great bio-compatibility; an can be absorbed and metabolized slowly by human body without adverse side effects, overcoming certain adverse effects of conventional drug-coated stents.Type: ApplicationFiled: October 10, 2008Publication date: August 18, 2011Applicant: MicroPort Medical (Shanghai)Co., Ltd.Inventors: Qiyi Luo, Zhirong Tang, Buzhong Zheng
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Patent number: 7998524Abstract: Methods are disclosed to improved adhesion of polymer coatings over polymer surfaces of stents which include plasma treatment, applying an adhesion promoting layer, surface treatments with solvents, and mechanical roughening techniques.Type: GrantFiled: December 10, 2007Date of Patent: August 16, 2011Assignee: Abbott Cardiovascular Systems Inc.Inventors: Yunbing Wang, Daniel A. Castro, Stephen D. Pacetti
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Patent number: 7993738Abstract: Modified porous materials are disclosed having interconnected, complexly shaped three-dimensional surfaces. The modification is accomplished by crosslinking the three-dimensional surfaces or by incorporating, in situ, an inorganic material onto or into three-dimensional surfaces. The porous materials are macro structures including at least one of nano-features, micro-features, and combinations thereof. The modifying accomplishes changing surface properties of the porous materials, changing the three-dimensional surfaces, and/or rendering the porous materials substantially stable in a predetermined environment.Type: GrantFiled: January 25, 2008Date of Patent: August 9, 2011Assignee: The Regents of the University of MichiganInventors: Peter X. Ma, Xiaohua Liu
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Publication number: 20110190866Abstract: Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.Type: ApplicationFiled: July 17, 2009Publication date: August 4, 2011Inventors: Klaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Niels Grabow, David P. Martin, Simon F. Williams