Abstract: An oral gel composition suitable for the treatment of oral leukoplakia comprising a combination of diclofenac with hyaluronic acid and methods of administering the oral gel that may include a device that prolongs contact time of the oral gel with the areas of the mucosa that are affected by oral leukoplakia.

Abstract: An oral care composition comprising zinc phosphate, stannous fluoride and a salicylamide, as well as methods of using the same.

Abstract: A dental adhesive composition, having a solvent which is an azeotrope of methyl ethyl ketone with water. Optionally, the azeotropic solvent may comprise in addition, ethanol or isopropanol. The boiling point of the solvent is less than 75° C.

Abstract: There is provided herein a dental Caries Status Disclosing Solution comprising a water-based silver fluoride solution for use in the initial application of the silver fluoride solution to a carious lesion followed by the subsequent application of a reducing agent solution for the visual analysis of the status of the carious lesion wherein the water-based silver fluoride solution comprises nitric acid to stabilise the water-based silver fluoride solution.

Abstract: A method for 3-D cephalometric analysis of a patient, executed at least in part on a computer processor, displays reconstructed volume image data from a computed tomographic scan of a patient's head from at least a first 2-D view and accepts an operator instruction that positions and displays at least one reference mark on the at least the first displayed 2-D view. One or more dentition elements within the mouth of the patient are segmented and cephalometric parameters for the patient computed and displayed according to data from the at least one reference mark and the one or more segmented dentition elements. Using the computed cephalometric parameters, one or more results indicative of maxillofacial asymmetry are computed and a graphical or text display energized to show the computed results indicative of asymmetry.

Abstract: A mouthguard (200) comprising: a base portion (210); an inner wall (212) extending from an inner edge (214) of the base portion; and an outer wall (216) extending from an outer edge (218) of the base portion, wherein an internal angle (234a-e) between the base portion and at least a portion of the outer wall is less than 90 degrees and an internal angle (232a-e) between the base portion and at least a portion of the inner wall is less than 90 degrees for gripping teeth of a wearer.

Abstract: The present invention relates to a cyanoacrylate composition having a heterogeneous curing initiator which is a hydrated calcium silicate. The composition is suitable for repairing and filling depressions, cracks, or holes in a substrate or between substrates to be bonded. It also relates to an adhesive comprising said composition, to a syringe containing it, to a method for bonding substrates, to the use of said composition, and to the use of said hydrated calcium silicate as curing agent for cyanoacrylate compositions.

Abstract: A dental composition comprising a polymerizable monomer (1), initiator, filler component(s) in an amount of more than about 20 wt.-%, wt.-% with respect to the whole weight of the composition, the polymerizable monomer (1) being characterized as follows: having exactly two (meth)acrylate reactive moieties, having an unsymmetrical backbone as linkage between the (meth)acrylate reactive moieties, the two (meth)acrylate reactive moieties being attached onto the unsymmetrical monomer backbone as alkyl esters, the unsymmetrical backbone comprising one aromatic moiety of the phenolic type, the polymerizable monomer (1) not containing an acidic moiety, other atoms than carbon, hydrogen, nitrogen, and oxygen, a bisphenol moiety. The invention is also directed to the use of the dental composition as or for producing a dental filling material, dental cement, crown and bridge material, inlay, onlay, veneer, orthodontic device or dental mill blank.

Abstract: A drug delivery device 10 has a support structure 20 and a medicine-laden member 100 affixed or otherwise attached to the support structure 20. The device 10 is sized to fit into the mouth and upon exposing the medicine-laden member 100 to saliva, medicaments 101 are released into the mouth. The drug delivery device 10 permits a new method of medication delivery. The method of oral transmucosal drug delivery has the steps of providing a drug delivery device 10 that fits into the mouth, the device 10 having a medicine-laden member 100; wearing the drug delivery device 10; activating release of medicine 101 by contact with saliva; and transmitting the released medicine 101 transmucosally to the bloodstream.

Abstract: A photo-chemically activated micro-bubble based root canal disinfection method for disinfecting a shaped root canal comprises (a) introducing a photoactive solution into the root canal, the photoactive solution containing a photoactive compound (such as methylene blue) dissolved in an alcohol carrier solution (such as polyethylene glycol and/or ethanol); (b) removing excess photoactive solution from the root canal; (c) introducing a micro-bubble solution comprised of an oxygen carrier (such as perfluorocarbon), an oxidizing agent (such as hydrogen peroxide) and a surfactant (such as a nonionic polyoxyethylene surfactant); (d) sonically or ultrasonically activating the micro-bubble solution in the canal; and (e) introducing light into the canal.

Abstract: An appliance fabricated to improve the appearance of a patient's smile includes a plurality of simulated teeth. The interior surfaces of each of the teeth closely fits and conforms to the surface of a patient's real teeth while the outer surfaces of each of the simulated teeth has an ideal surface configuration. The dental appliance provides the patient with the appearance of a perfect set of teeth and an ideal smile without a need to alter the dental structure of the patient's teeth.

Abstract: A non-invasive method for making a tooth veneer from composite resin material for a patient's tooth without tooth reduction, enamel removal or any invasive tooth preparation, comprising the steps of transferring an amount composite resin material on the patient's tooth without prior invasive tooth preparation; forming a preview veneer from the composite resin material directly on the tooth; requesting the patient to approve or disapprove the preview veneer; if approved, requesting the patient whether to have a first method veneer or a second method veneer. A kit for a non-invasive method of making a tooth veneer for a patient's tooth without tooth reduction, enamel removal or any invasive tooth preparation.

Abstract: An adhesive dental composition comprising a polymerizable monomer (1), a polymerizable monomer (2) comprising an acidic moiety, initiator component(s), filler component(s) in an amount of less than about 15 wt.-%, wt.-% with respect to the whole weight of the composition, the polymerizable monomer (1) being characterized as follows: having exactly two (meth)acrylate reactive moieties, having an unsymmetrical backbone as linkage between the (meth)acrylate reactive moieties, the two (meth)acrylate reactive moieties being attached onto the unsymmetrical monomer backbone as alkyl esters, the unsymmetrical backbone comprising one aromatic moiety of the phenolic type, the polymerizable monomer (1) not containing an acidic moiety, other atoms than carbon, hydrogen, and oxygen, bisphenol moieties. The invention also relates to the use of the adhesive dental composition as dental adhesive, sealant, cement or for bonding or cementing a material to the surface of hard dental tissue.

Abstract: Addition-fragmentation oligomers of the general formula Z—By-A-(B-A)x-B-A-By—Z, where the A monomers units are derived from a diester or diacid, the B monomer units are derived from a difunctional monomer having functional groups co-reactive with the acid or ester groups of the A monomer, x+y is zero to 60, Z comprises an ethylenically unsaturated, polymerizable group, A monomers comprise a 1-methylene-3,3-dimethylpropyl group, and at least one B monomer unit comprises a high refractive index group.

Abstract: An oral appliance is provided for delivering a medicament to at least a portion of teeth and/or soft tissue areas inside a mouth, the oral appliance comprising an interior surface having a porous material disposed on at least a portion of the interior surface of the oral appliance, the porous material containing a medicament and the interior surface being formed to fit contours of at least the portion of the teeth and/or soft tissue areas inside the mouth and being capable of supporting and holding the porous material in contact with at least the portion of the teeth and/or soft tissue areas inside the mouth to deliver the medicament.

Abstract: Methods, compositions, and products maintain white teeth or prolong the effects of teeth whitening by preventing staining of teeth via a temporary stain repellent. The temporary stain repellent can include a food-grade silicone compound configured to temporarily form a protective layer over teeth or fill the pores of the teeth before and during the consumption of pigmented foods and/or drinks post-teeth whitening.

Abstract: A dental adhesive composition has an adhesive component and an activator component. The adhesive composition has a volatile organic solvent component, one or more polymerizable (meth)acrylate compounds optionally containing fillers, and a polymerization photoinitiator. The adhesive component may also be a substantially homogeneous mixture of one or more polymerizable (meth)acrylate compounds and an effective amount of a photoinitiator, without a solvent. The activator component includes an aromatic sulfinate salt and an activator component solvent. A method for adhering a restorative to a dental surface includes preparing the surface for restoration; applying a mixture of an adhesive component and an activator component to the prepared cavity, thereby forming a coated cavity surface; and, applying a direct or indirect dental restorative to the coated cavity surface.

Abstract: The present invention provides a phosphopeptide or phosphoprotein (PP) stabilised amorphous calcium phosphate or amorphous calcium fluoride phosphate complex having a calcium ion greater than about 30 moles of calcium per mole of PP.

Abstract: This invention relates to a composition useful as a dentifrice comprising a surfactant agent consisting essentially of monoalkyl and dialkyl phosphate esters, wherein the ratio of monoesters to diesters is greater than 1, and optionally an abrasive agent consisting essentially of siliceous materials.

Abstract: The invention discloses a partially elastic shaped body in the form of a negative image of a dental arch containing a matrix based on a gel containing an active substance or a system with a mineralizing effect as well as an application system for the treatment of teeth. The application system comprises an application dental splint that is well-suited for use on the upper and/or lower jaw, whereby the dental splint can accommodate at least one first three-dimensional shaped body that is adapted to the splint and contains a matrix, preferably the dental splint can be deformed by heat. The matrix of the at least one first and optionally further shaped body contains at least one active substance or a system with a mineralizing effect containing phosphates, calcium, and fluorides. The method for producing the application system and a kit comprising the application system are also a subject matter of the invention.

Abstract: An oral care kit is provided. The oral care kit is designed to be used to treat a painful area of a patient's mouth, such as a tooth, an area of a lip, or an area along a gum line. The oral care kit generally includes a topical anesthetic, a plurality of disposable swabs, and an applicator. The applicator has a proximal end defining a handle, and a distal end comprising a pair of prongs. A channel is formed along an inner surface of the prongs. The proximal end of each swab is dimensioned to be slidably received within the channel, while the distal end comprises flocking. Each of the disposable swabs is dimensioned to be received within a user's mouth for application of the topical anesthetic. A method of numbing a dental area is also provided herein.

Abstract: The invention proposes a kit and formulations for biomimetic deposition of apatite on teeth from a partially elastic shaped body comprising an envelope, whereby the shaped body a) comprises at least one mineralization matrix containing a gel that comprises water-soluble phosphates or phosphates that can be hydrolysed to form water-soluble phosphate ions and has a pH value of 2 to 8, optionally fluorides, and b) the at least one or a second mineralization matrix comprises a second gel having a pH value of 3.5 to 14 comprising calcium ions or compounds releasing calcium ions. Moreover, the method for producing the formulation and the use thereof for the deposition of apatite, in particular of needle-shaped fluorapatite crystallites, is claimed. Using the formulations according to the invention, it is feasible to deposit more than or equal to 1 ?m apatite, in particular fluorapatite, on tooth surfaces in order to seal or brighten porous tooth surfaces.

Abstract: Mouth rinses, dentifrices, lozenges, confections, chewing gums, and similar delivery vehicles containing non-toxic soluble calcium are used prior to administration of a fluoride-containing composition to increase the effectiveness of the fluoride therapy. An effective amount of calcium is released into the oral cavity and allowed to penetrate into the oral tissue. Calcium-bound fluoride deposits form in the oral tissue upon subsequent administration of the fluoride-containing composition to provide increased salivary, plaque and oral tissue fluoride concentrations.

Abstract: Stable tooth bleaching gels with a high concentration of peroxide are disclosed. The present invention also provides a method for treating one or more teeth. The method includes steps of applying a therapeutically effective amount of a tooth bleaching gel with a high concentration of peroxide to one or more teeth, leaving the gel in contact with the one or more teeth such that the gel may whiten the tooth or teeth.

Abstract: The invention proposes formulations for biomimetic deposition of apatite from a partially elastic shaped body on teeth, whereby the shaped body a) contains at least one mineralization matrix containing a gel that comprises water-soluble phosphates or phosphates that can be hydrolyzed to form water-soluble phosphate ions and has a pH value of 2 to 8, optionally fluorides, and b) the at least one or a second mineralization matrix comprises a second gel having a pH value of 3.5 to 14 comprising calcium ions or compounds releasing calcium ions. Moreover, the method for producing the formulation for the deposition of apatite, in particular of needle-shaped fluorapatite crystals, is claimed. Using the formulations according to the invention, it is feasible to deposit more than or equal to 1 ?m apatite, in particular fluorapatite, on tooth surfaces in order to seal or brighten porous tooth surfaces.

Abstract: Provided herein is a strip, shaped for the application to the labile surface of the front teeth and/or gums of a subject, which strip is provided with at least one oral care composition for delivery to a pre-determined area of the teeth and/or gums of the subject. Also provided herein are uses for delivery of compositions. Further provided are uses of the strip in combination with a dental device.

Abstract: An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an anchor layer overtop the backing layer, and an oral care layer overtop the anchor layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. The oral care layer is in contact with the anchor layer and forms an adhesive bond with the anchor layer; however, the oral care layer is minimally invested in the anchoring layer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.

Abstract: Disclosed are systems, methods, compositions and kits for mineralizing tissue, particularly dental tissue. The methods, compositions and kits may be used to strengthen and prevent weakening of the tissue. For example, the methods, compositions and kits may be used for treating and filling cavities in teeth caused by tooth decay.

Abstract: An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.

Abstract: The present invention relates to a handheld dental device that provides photodynamic therapy. The device of the present invention may have an elongated housing; an applicator tip extending from the distal end of the housing; wherein the applicator tip has a lumen defined by a wall; an optic fiber extending through the lumen of the applicator tip; at least one power source attached to or residing within the housing; at least one light source that provides light to the optic fiber and emits a wavelength that ranges from about 650 nm to about 1400 nm; and at least one oxygen source that provides oxygen to a passage that communicates with the oxygen source and the applicator tip. Oxygen and light may be provided at the applicator tip simultaneously. The device may be used to eliminate or reduce bacteria which cause oral disease or conditions, such as endodontic treatment failures.

Abstract: Composition and methods include a dental bleaching agent, potassium nitrate a fluoride salt for enhanced whitening and reduced tooth sensitivity. The potassium nitrate and fluoride salt both reduce or eliminate tooth sensitivity that may otherwise be caused by the bleaching agent. For prolonged treatment of teeth, lower quantities of potassium nitrate (e.g., 0.5%) have actually been found to work better than larger quantities (e.g., 3%). The dental compositions may be applied directly to the person's teeth, or they may be loaded into a comfortable fitting, flexible, thin-walled dental tray and placed over the person's teeth. In that case, the dental compositions will include a tackifying agent, such as carboxypolymethylene, which assists the composition in retaining the dental tray over the person's teeth as a result of the adhesive properties of the dental composition rather than due to mechanical interlocking of the tray over the person's teeth.

Abstract: The object of the present invention is to provide an oral composition, which can remove tooth stain effectively. The object of the present invention is also to provide an oral composition, which scarcely damages teeth and gums and can be easily applied. An oral composition for removing tooth stain, which comprises 3.5 to 30% by weight of peroxide and 5 to 20% by weight of phosphate polymer (in particular, ultraphosphate having an average chain length of phosphoric acid polymerization of 10 to 30).

Abstract: The present disclosure provides methods and compositions comprising ascorbyl esters for the treatment or reduction of dental conditions in an animal. A pet food composition of the disclosure can be a dry food composition comprising (i) a matrix of ingredients nutritionally or organoleptically adapted for the animal and (ii) an outer coating layer, wherein the outer coating layer is applied to the matrix as a solution comprising an effective amount of an ascorbic acid fatty acid ester dissolved in a plant oil. One disclosed method of treatment or reduction involves feeding an animal in need of such treatment a dry pet food composition of the disclosure. A second disclosed method comprises applying to one or more surfaces of one or more teeth of an animal in need of such treatment, an effective amount of a solution comprising an ascorbic acid fatty acid ester dissolved in a plant oil.

Abstract: The invention provides novel dental film-forming compositions, comprising i. an acrylate/octylacrylamide copolymer, ii. one or more alkyl cellulose ethers, and iii. a solvent, and optionally further comprising whitening materials and/or active agents, together with method for using the same.

Abstract: A method is provided for enhancing the results of an optical scan of the surface of an object such as human dentition in which the surface may be dry or wet. The method includes the step of applying a composition to the surface, wherein the composition includes a volatile component that rapidly evaporates resulting in the transformation of the residual composition to a durable, water insoluble, non sticky film on the surface, whether applied in a dry-field or in a wet-field environment. The composition generally includes an agent that improves the quality of the optical return signal to a 3D optical scanner. The method further includes the steps of scanning the surface having the film with an optical scanner and then, once scanning has been completed, using an organic solvent, such as a mouthwash containing alcohol, to remove the film from the object's surface.

Abstract: The present invention is directed to implantable compositions comprising substantially spherical bioactive glass particles.

Abstract: A hand-held, ergonomic instrument with an LED that emits actinic light in visible wavelengths mounts a replaceable applicator cup with a reservoir for a tooth whitening composition held in place against a user's tooth during a whitening procedure. Actinic light is directed onto the tooth surface through a window in the cup and the tooth whitening composition substantially without attenuation, delivering at least about 100 milliwatts per square centimeter of light energy to the tooth surface. The cup includes a rigid body for mounting the cup to the instrument and an opaque flexible sleeve molded in place over the outside of the body to form a seal with the tooth surface and prevent exposure of soft mouth surfaces to the actinic radiation during a whitening procedure. A safety switch disables the LED when the applicator cup is not in contact with a tooth surface.

Abstract: A delivery device (12) includes a source (16) of pressurized fluid, a nozzle (24, 16) which defines an outlet (22), a pathway (20) which fluidly connects the source of pressurized fluid with the nozzle outlet (22) for delivery of a spray of fluid from the nozzle outlet, and a receptacle (32), which receives a dose of particles (28). The receptacle is positioned in the pathway such that the dose of the particles is carried by the pressurized fluid and through the nozzle outlet, the particles including a tooth whitening agent.

Abstract: Presently described are curable dental compositions comprising a polymerizable ionic liquid. The polymerizable ionic liquid comprises one or more ethylenically unsaturated (e.g. free-radically polymerizable) groups. Various embodiments of curable dental compositions are described. In some embodiments, the polymerizable ionic liquid is a monofunctional polymerizable ionic liquid comprising an ethylenically unsaturated group. In other embodiments, the polymerizable ionic liquid is a multifunctional polymerizable ionic liquid comprising at least two ethylenically unsaturated groups. The curable dental compositions describe herein can be utilized as dental primers, dental adhesives, dental sealants, and dental composites. In many embodiments, the curable dental compositions further comprise an initiator such as a photoinitiator.

Abstract: Fluoride varnish compositions for temporary application and adhesion to a person's teeth. The composition includes a carrier comprising a resin and an adhesion promoting agent comprising an alkyl phosphoric acid. A fluoride ion source (e.g., a fluoride salt such as sodium fluoride) is dispersed within the carrier so as to provide biologically available fluoride ions to the tooth tissue being treated. The composition adheres only temporarily to tooth tissue (e.g., for a period of at least about 4 minutes, but not more than about 1 year), after which the composition spontaneously wears away as a natural result of the action of the tongue, saliva and/or other factors.

Abstract: A dental bleaching composition comprises a dental bleaching agent and a polyvinylpyrrolidone thickening agent. The bleaching composition may include water, flavoring agents, a basic substance and desensitizing agents, as desired. Polyvinylpyrrolidone avoids acid etching and chelation of teeth that were problematic in bleaches using carbomer as a thickener. A delivery system for delivering the bleaching composition comprises the aforementioned dental bleaching composition in combination with a moisture-resistant barrier layer such as a dental tray or a flexible strip of material.

Abstract: A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer. The composition also includes a backing member. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening. The composition can be designed to be removed when the degree of whitening has been achieved or left in place and allowed to erode entirely. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

Abstract: A tooth whitening system comprising a dental tray having a surface operable to confront a tooth surface, and a tooth whitening composition comprising a whitening agent and a hydrophobic polymer carrier. The tooth whitening composition is preferably substantially non-water soluble. A tooth whitening kit is also provided using a dental tray and the tooth whitening composition comprising a whitening composition and a hydrophobic polymer carrier.

Abstract: Methods for making a layered dental appliance. Some methods can include providing a solid structure (e.g., a die or a dental core, such as a fully sintered ceramic dental core) having a desired outer shape, and applying a first slurry to the solid structure to form a first free form layer on the solid structure. The method can further include solidifying the first free form layer on the solid structure, and machining the solidified first free form layer to a desired shape to form a first article comprising the solid structure and a first shaped layer. The method can further include applying, solidifying, and machining a second layer in a similar way to form a second article comprising the solid structure, the first shaped layer, and a second shaped layer. In some methods, the free form layers are not exposed to a high temperature prior to being machined.

Abstract: A device that is useful in forming an occupation for an edentulous space, and a method of forming the device. The device is formed by filling a tube with an ultraviolet (UV) light curable composite, and subsequently curing the light curable composite in situ. The tube is transparent, or substantially transparent, to ultraviolet (UV) light. The tube may be open at each end thereof.

Abstract: A device, method, and system are provided for aiding the whitening of teeth. The device includes a mouthpiece suitable for implementing a dental treatment, wherein the mouthpiece includes one or more stock dental cover layers suitable for forming a treatment cavity having a vacuum, wherein the dental cover layers includes a layer over the upper teeth and/or a layer over the lower teeth; and one or more treatment supply layers wherein the treatment supply layer has one or more flow channel in fluid communication with the treatment cavity so that the treatment supply layer can deliver and/or remove one or more treatment fluids from the treatment cavity.

Abstract: Disclosed herein are methods of treating an intraoral surface by applying a solution comprising a proteinaceous material and an aldehyde.

Abstract: This invention pertains to dental care compositions with antimicrobial benefits. In particular, the invention provides for compositions of oral tissue-adherent salts that release biocidal ions on a controlled release basis and thereby provide and maintain an essentially uniform concentration of biocidal ions above the MBC or MIC of the target bacteria at the site of application in the mouth for an extended period of time. The compositions are useful for treating or preventing oral diseases resulting from bacteria, fungal or yeast infections, such as caries, gingivitis, periodontal disease and candidiasis.

Abstract: The invention describes the modification of polyamine-based materials to form polyguanidine compounds that are useful for their antimicrobial, anticaries, and muccoadhesive properties. The present invention also relates to methods for preventing or treating periodontal disease and caries which include delivering a therapeutically effective amount of an oral composition containing a polyguanidine compound into an oral cavity.

Abstract: Adhesive patches for non-invasive pain relief comprising a molded backing layer including first and second well portions. An adhesive composition (e.g., chitosan derived) is disposed within the first well composition, and a skin penetrating anesthetic composition is disposed within the second well portion. The first well portion surrounds the perimeter of the second well portion, creating a barrier to prevent or minimize migration of the anesthetic composition outside the perimeter of the second well portion, targeting delivery to the desired site. The skin penetrating anesthetic composition includes a skin penetrating carrier (e.g., DMSO with small fractions of water and ethanol), a primary adhesive component (e.g., hydroxypropyl cellulose) to render the anesthetic composition sticky to the person's tissue, and at least one anesthetic component (e.g., -caine based components). Where two anesthetic components are included, one may act more rapidly to anesthetize pain than the first anesthetic component.