Containing Six-membered Hetero Ring (e.g., Fluorescein, Etc.) Patents (Class 435/125)
-
Patent number: 4783402Abstract: A process for producing a primary or secondary alcohol derivative of a phosopholipid which comprises reacting the phospholipid with a primary or secondary alcohol in the presence of phospholipase DM.Type: GrantFiled: April 10, 1984Date of Patent: November 8, 1988Assignee: Meito Sangyo Kabushiki KaishaInventors: Yoshitaka Kokusho, Shigeaki Kato, Haruo Machida
-
Patent number: 4782019Abstract: A process for producing a sphingophospholipid derivative comprising reacting a sphingophospholipid with a specified compound having an alcoholic hydroxyl group selected from the group consisting of specified primary alcohol compounds, specified secondary alcohol compounds and specified saccharides or their phenol glycosides in the presence of phospholipase DM.Type: GrantFiled: April 10, 1984Date of Patent: November 1, 1988Assignee: Meito Sangyo Kabushiki KaishaInventors: Yoshitaka Kokusho, Shigeaki Kato, Haruo Machida
-
Patent number: 4755467Abstract: A method for the simultaneous production of sorbitol and either gluconolactone or gluconate from glucose and fructose. To this end to produce sorbitol and gluconolactone, glucose and fructose are reacted in the presence of a cell or cell-free extract of a bacteria, which contains the enzyme complex glucose/fructose transhydrogenase including the tightly bound co-factor(s), under condition whereby the further metabolism of gluconolactone is substantially prevented. In order to produce sorbitol and gluconate glucose and fructose are reacted in the presence of a cell or cell-free extract of a bacteria which contains an enzyme system comprising the enzyme complex glucose/fructose transhydrogenase including the tightly bound co-factor(s) and the enzyme gluconolactonase. This reaction is carried out under conditions whereby the metabolism of gluconate is substantially prevented. Preferably the bacteria used in this process is of the genus Zymomonas and most preferably of the species Zymomonas mobilis.Type: GrantFiled: November 26, 1985Date of Patent: July 5, 1988Assignee: Unisearch LimitedInventors: Robert K. Scopes, Peter L. Rogers, Donald A. Leigh
-
Patent number: 4716113Abstract: An improved process for preparing (4S)-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione (sorbinil) or its (2R)-methyl derivative (2-methylsorbinil) is disclosed herein, starting from p-fluorophenol in each instance. The final products obtained have known pharmaceutical value as agents for the control of certain chronic diabetic complications. Key steps concerned with the process involve converting p-fluorophenol into the appropriate .beta.-(4-fluorophenoxy)alkane halide, followed by amidoalkylation with N-benzoyl or N-(lower alkanoyl)-.alpha.-hydroxyglycine to form an intermediate 2-amidoalkylated derivative thereof, and then dehydration and spiroalkylation of said intermediate by treatment with a dehydrating agent and a base to yield a spiroalkylated azlactone compound.Type: GrantFiled: March 31, 1986Date of Patent: December 29, 1987Assignee: Pfizer Inc.Inventor: Frank J. Urban
-
Patent number: 4588822Abstract: Disclosed are novel physiologically active substance SS 12538, process for its preparation and a novel microorganism producing the same.The novel physiologically active substance SS 12538 is represented by the following formula (I): ##STR1## in which R represents a hydrogen atom, a methyl group or an ethyl group. SS 12538 is obtained by inoculating a novel strain S 12538 in a nutrient-containing medium and cultivating aerobically.SS 12538 has excellent vasodilating action and antibiotic action against a certain gram positive bacteria and dermatophytes.Type: GrantFiled: April 6, 1983Date of Patent: May 13, 1986Assignee: SS Pharmaceutical Co., Ltd.Inventors: Junji Oono, Kenichi Yano, Junichi Sato, Tadayuki Kouda, Yoichiro Ogawa, Kouichi Yokoi, Toshiaki Nakashima
-
Patent number: 4536474Abstract: An undifferentiated symbiotic combination of alga and fungus cells, obtained directly from a lichen explant, are cultured in a media under appropriate conditions to produce aromatic lichenous substances and these substances are recovered.Type: GrantFiled: September 30, 1982Date of Patent: August 20, 1985Assignee: Nippon Paint Co., Ltd.Inventors: Yoshikazu Yamamoto, Ryuzo Mizuguchi, Yasuyuki Yamada
-
Patent number: 4478935Abstract: Manganese complexes of various monovalent and divalent polyether antibiotics are provided which act as coccidiostats and growth promoting agents when administered to food-producing animals such as cattle, sheep, swine and poultry. Soluble manganese salt is added to a fermentation beer containing the polyether antibiotics to form an insoluble, recoverable biomass containing the desired manganese antibiotic complex. This biomass, in a dried form, can be given orally to animals such as cattle, sheep, swine and poultry.The subject manganese complexes include: linear monovalent and divalent polyethers (monensin, nigericin, lasalocid, lysocellin, etc.); non-glycolic monovalent monoglycoside polyethers (septamycin, dianemycin, lenoremycin, carriomycin and antibiotic A-204); mononitrogen-containing divalent pyrrole ethers (calcimycin, X-14547, etc.); polynitrogen-containing divalent pyrrole ethers (A-23187, etc.); glycolic monovalent monoglycoside polyethers (etheromycin, etc.Type: GrantFiled: September 20, 1982Date of Patent: October 23, 1984Assignee: International Minerals & Chemical Corp.Inventors: Robert D. Williams, David R. Bright, Vernon V. Young, Jerome L. Martin
-
Patent number: 4415669Abstract: There is disclosed a macrolide isolated from the fermentation broth of a microorganism identified as MA-5285 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compound's structure is presented based upon analytical studies. The compound has insecticidal and antiparasitic activity.Type: GrantFiled: December 7, 1981Date of Patent: November 15, 1983Assignee: Merck & Co., Inc.Inventor: Sebastian Hernandez
-
Patent number: 4414226Abstract: 1,4-naphthoquinone derivatives represented by the following general formula: ##STR1## (wherein R.sup.1 represents a hydrogen atom, a hydroxy group, a lower alkoxy group or an arylthio group, R.sup.2 represents a carboxy group, an esterified carboxy group or an amidated carboxy group or, when taken together, R.sup.1 and R.sup.2 form a group of ##STR2## R.sup.3 represents a hydrogen atom or a lower alkyl group, R.sup.4 represents a lower alkyl group, R.sup.5 represents a hydrogen atom or a halogen atom, and R.sup.6 represents a hydrogen atom, a lower alkyl group or a lower alkanoyl group), and the salts of the carboxy group thereof, which are novel compounds having an anticoccidium activity, and which can be obtained by synthesis or, partly, by cultivation of Streptomyces auranticolor.Type: GrantFiled: October 30, 1981Date of Patent: November 8, 1983Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Koichi Ikushima, Hirokazu Tanaka, Ohe Osamu, Eiko Kino, Masanobu Kohsaka, Hatsuo Aoki, Akira Arakawa, Hiroshi Imanaka
-
Patent number: 4397950Abstract: Novel antibiotic U-64,767 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces macronensis Dietz sp.n., NRRL 12566. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus and Streptococcus pyogenes. It is also active against the Gram-negative bacterium Streptococcus pneumoniae. Thus, antibiotic U-64,767 can be used in various environments to eradicate or control such bacteria.Type: GrantFiled: November 23, 1981Date of Patent: August 9, 1983Assignee: The Upjohn CompanyInventors: Lester A. Dolak, Fritz Reusser, Thomas M. Castle, Betty R. Hannon, Alice L. Laborde, Charles K. Marschke
-
Patent number: 4366248Abstract: The present invention concerns isoflavones and related compounds useful as antioxidants and in antioxidant compositions including edible fats and oils. Many of these compounds can be recovered from tempeh, a fermented soybean product. Others can be prepared by chemical modification of those recovered from tempeh. Additionally, all of the compounds can be chemically synthesized. The compounds of the present invention may be used to provide enhanced stability for a wide range of substances subject to oxidative deterioration including edible food products, oils and fats.Type: GrantFiled: January 19, 1981Date of Patent: December 28, 1982Assignee: Z-L Limited PartnershipInventor: Fritz W. Zilliken
-
Patent number: 4353986Abstract: The present invention teaches a new antibiotic nanaomycin E represented by the formula: ##STR1## Nanaomycin E is active against Gram-positive bacteria, Trichophyton and Mycoplasma and may be used as antibacterial and therapeutic agents for humans and animals. Nanaomycin E is also a useful starting material for the preparation of nanaomycin A which latter nanaomycin has the highest activity among the various nanaomycin-type compounds. Nanaomycin E is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing nanaomycin E, especially Streptomyces rosa variant notoensis (FERM-P 2209; ATCC 31135) and recovering the same from the fermented liquor.Type: GrantFiled: June 22, 1981Date of Patent: October 12, 1982Assignees: Kyowa Hakko Kogyo Kabushiki Kaisha, Kitasato KenkyushoInventors: Satoshi Omura, Haruo Tanaka, Itaru Takahashi, Shinzo Ishii, Kazuyuki Mineura, Kunikatsu Shirahata, Masaji Kasai
-
Patent number: 4343814Abstract: Substances isolated after cultivation of a microorganism belonging to the genus Penicillium in a culture medium comprises compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesterolemic and hypolipemic medicaments.Type: GrantFiled: November 17, 1980Date of Patent: August 10, 1982Assignee: Merck & Co., Inc.Inventors: Vincent P. Gullo, Tony Y. K. Lam, Richard L. Monaghan
-
Patent number: 4342767Abstract: Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.Type: GrantFiled: June 16, 1980Date of Patent: August 3, 1982Assignee: Merck & Co., Inc.Inventors: George Albers-Schonberg, Richard L. Monaghan, Alfred W. Alberts, Carl H. Hoffman
-
Patent number: 4323648Abstract: Monacolin K, which is an antihypercholesteraemic agent of molecular formula C.sub.24 H.sub.36 O.sub.5, is prepared by cultivating one or more of the microorganisms Monascus anka SANK 10171 (IFO 6540), Monascus purpureus SANK 10271 (IFO 4513), Monascus ruber SANK 10671 (FERM 4958), Monascus vitreus SANK 10960 (FERM 4960), Monascus paxii SANK 11172 (IFO 8201), Monascus ruber SANK 13778 (FERM 4959), Monascus ruber SANK 15177 (FERM 4956) or Monascus ruber SANK 18174 (FERM 4957) in a suitable culture medium and then isolating the Monacolin K from the resulting culture broth.Type: GrantFiled: April 4, 1980Date of Patent: April 6, 1982Assignee: Sankyo Company LimitedInventors: Kazuhiko Tanzawa, Seigo Iwado, Yoshio Tsujita, Masao Kuroda, Kouhei Furuya
-
Patent number: 4319039Abstract: Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.Type: GrantFiled: August 11, 1980Date of Patent: March 9, 1982Assignee: Merck & Co., Inc.Inventor: George Albers-Schonberg
-
Patent number: 4304855Abstract: The present invention relates to a fermentation process for producing allylic methyl-hydroxylated novobiocin and derivatives thereof.Type: GrantFiled: May 5, 1977Date of Patent: December 8, 1981Assignee: The Upjohn CompanyInventors: Oldrich K. Sebek, Lester A. Dolak
-
Patent number: 4304860Abstract: Novel compounds prepared by microbial transformation using novel mutants to selectively degrade steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive. These compounds can be used as intermediates to make useful steroids.Type: GrantFiled: February 13, 1978Date of Patent: December 8, 1981Assignee: The Upjohn CompanyInventors: John C. Knight, Merle G. Wovcha
-
Patent number: 4296040Abstract: The present invention teaches a new antibiotic nanaomycin E represented by the formula: ##STR1## Nanaomycin E is active against Gram-positive bacteria, Trichophyton and Mycoplasma and may be used as antibacterial and therapeutic agents for humans and animals. Nanaomycin E is also a useful starting maerial for the preparation of nanaomycin A which latter nanaomycin has the highest activity among the various nanaomycin-type compounds. Nanaomycin E is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing nanaomycin E, especially Streptomyces rosa variant notoensis (FERM-P 2209; ATCC 31135) and recovering the same from the fermented liquor.Type: GrantFiled: November 23, 1970Date of Patent: October 20, 1981Assignees: Kyowa Hakko Kogyo Kabushiki Kaisha, Kitasato KenkyushoInventors: Satoshi Omura, Haruo Tanaka, Itaru Takahashi, Shinzo Ishii, Kazuyuki Mineura, Kunikatsu Shirahata, Masaji Kasai
-
Patent number: 4294926Abstract: Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise a compound designated MSD803 which has the lactone structure: ##STR1## as well as its free hydroxy acid form. Together with salts and esters of the free acid form, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.Type: GrantFiled: January 23, 1980Date of Patent: October 13, 1981Assignee: Merck & Co., Inc.Inventors: Richard L. Monaghan, Alfred W. Alberts, Carl H. Hoffman, George Albers-Schonberg
-
Patent number: 4231938Abstract: Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise a compound designated MSD803 which has the lactone structure: ##STR1## as well as its free hydroxy acid form. Together with salts and esters of the free acid form, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.Type: GrantFiled: June 15, 1979Date of Patent: November 4, 1980Assignee: Merck & Co., Inc.Inventors: Richard L. Monaghan, Alfred W. Alberts, Carl H. Hoffman, George Albers-Schonberg
-
Patent number: 4205002Abstract: A compound of formula (II), named pseudomonic acid C or a salt or ester thereof: ##STR1## has antibacterial and anti-mycoplasma activity, and can be produced either by fermentation of Pseudomonas fluorescens, or by de-oxygenation of pseudomonic acid A, the compound having a epoxide in place of the double bond. The compounds are therefore useful in the treatment of human and veterinary bacterial and mycoplasma-induced infections.Type: GrantFiled: October 27, 1978Date of Patent: May 27, 1980Assignee: Beecham Group LimitedInventors: Norman H. Rogers, Peter J. O'Hanlon
-
Patent number: 4196266Abstract: The present invention relates to new compound nanaomycin A and derivatives thereof represented by general formula: ##STR1## in which (a) R is H and R' is OH (nanaomycin A),(b) R is H and R' is NH.sub.2 (nanaomycin C),(c) R is COCH.sub.3 and R' is CH (acetylnanaomycin A), and(d) R is H and R' is OCH.sub.3 (nanaomycin A methyl ester).Nanaomycin A is a new compound of quinone type and its acute toxicity (LD.sub.50, intra-penetrial injection) in mice is 28.2 mg/Kg. Nanaomycin A and derivatives thereof are active on Gram-positive bacteria, trichophyton and mycoplasma and are useful as a medicament for humans and animals. Nanaomycins A and C are produced by culturing a nanaomycin-producing strain belonging to the genus Streptomyces aerobically in a medium to accumulate nanaomycins A and C in the cultured broths. The derivatives acetylnanaomycin A and nanaomycin A methyl ester have similar properties to those of nanaomycin A.Type: GrantFiled: December 7, 1977Date of Patent: April 1, 1980Assignee: The Kitasato Institute (Kitasato Kenkyuosho)Inventors: Satoshi Omura, Haruo Tanaka, Juichi Awaya, Toju Hata
-
Patent number: 4194064Abstract: The present invention relates to new compound designated as nanaomycin B represented by general formula: ##STR1## Nanaomycin B is a quinone type and is active on mycoplasma, Gram-positive bacteria and trycophyton. This compound is useful as a medicament for infectious diseases of humans and animals caused by a parasite of trichophyton or mycoplasma etc. The acute toxicity (LD.sub.50, intra-penetrial injection) in mice of this compound is 169 mg/kg. Nanaomycin B is produced by fermentation in which a nanaomycin-producing strain belonging to the genus Streptomyces is cultured in a medium under aerobic conditions and the accumulated nanaomycin B in the cultured broths is recovered therefrom.Type: GrantFiled: December 7, 1977Date of Patent: March 18, 1980Assignee: The Kitasato Institute (Kitasato Kenkyusho)Inventors: Satoshi Omura, Haruo Tanaka, Juichi Awaya, Toju Hata
-
Patent number: 4177106Abstract: Novel microbial transformation process to selectively convert steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to 3a.alpha.-H-4.alpha.-[3'-propanol]-7a.beta.-methylhexahydro-1,5-indaned ione hemiketal having the following structure: ##STR1## This compound can be used as an intermediate to make useful 19-nor steroids.Type: GrantFiled: February 21, 1978Date of Patent: December 4, 1979Assignee: The Upjohn CompanyInventors: Thomas R. Pyke, Marion P. Salmond