Amide (e.g., Chloramphenicol, Etc.) Patents (Class 435/129)
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Patent number: 8748661Abstract: The present invention relates to novel polyamino polyketide antibiotics, methods of their production as well as methods of using these antibiotics, for example, for inhibition or removal of biofilm formation or for treating bacterial infection with these antibiotics.Type: GrantFiled: November 9, 2009Date of Patent: June 10, 2014Assignee: Agency for Science, Technology and ResearchInventors: Jien Wu, Haibao Zhang, Lianhui Zhang
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Publication number: 20140134682Abstract: Recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine or N-acetylcadaverine, as well as recombinant DNA molecules and polypeptides used to produce the microorganisms are provided. Said microorganisms comprise an intracellular lysine decarboxylase activity and a deregulated cadaverine export activity, or comprise a decreased cadaverine export activity and an enhanced N-acetylcadaverine forming activity. Processes for the production of cadaverine N-acetylcadaverine using the recombinant microorganisms are also provided.Type: ApplicationFiled: February 20, 2012Publication date: May 15, 2014Applicant: BASF SEInventors: Christoph Wittmann, Stefanie Kind
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Publication number: 20140134683Abstract: The present invention relates to a method for producing acrylamide comprising: supplying a raw material water to a reactor, supplying acrylonitrile to the reactor, and hydrating acrylonitrile using a biocatalyst, wherein a temperature of the raw material water in the supplying step of the raw material water to the reactor is equal to or more than freezing point of the raw material water and lower than the reaction temperature by 5° C. or more. The present invention can be provided to the method of producing acrylamide which can be removed the reaction heat produced at the hydration reaction of acrylonitrile effectively with a low cost.Type: ApplicationFiled: May 29, 2012Publication date: May 15, 2014Applicant: Mitsubishi Rayon Co., Ltd.Inventors: Makoto Kanou, Kiyonobu Niwa
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Publication number: 20140120588Abstract: Improving wild nitrile hydratase enables the provision of a protein which has nitrile hydratase activity and which has further improved heat resistance, amide compound resistance and high temperature accumulation properties. Use protein (A) or (B), (A) being a protein characterised by having nitrile hydratase activity and by including an amino acid sequence in which a specific amino acid residue in an amino acid sequence in wild nitrile hydratase has been substituted by another amino acid residue, and (B) being a protein characterised by having nitrile hydratase activity and by including an amino acid sequence in which one or several amino acid residues in the amino acid sequence of protein (A), other than the abovementioned specific amino acid residue, is deleted, substituted and/or added.Type: ApplicationFiled: May 30, 2012Publication date: May 1, 2014Applicant: Mitsubishi Rayon Co., Ltd.Inventors: Fumiaki Watanabe, Takanori Ambo, Ai Hara
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Publication number: 20140106415Abstract: There is provided a method for producing an aqueous acrylamide solution by producing acrylamide by reacting a composition including acrylonitrile with water, in which the composition including acrylonitrile includes 20 to 80 mg of methacrylonitrile per 1 kg of the total weight of the composition including acrylonitrile. According to the present invention, a production method allowing stable obtainment of an aqueous acrylamide solution can be provided as polymerization of the acrylamide can be suppressed without causing a decreas+455e in quality.Type: ApplicationFiled: May 21, 2012Publication date: April 17, 2014Applicant: Mitsubishi Rayon Co., Ltd.Inventors: Makoto Kanou, Norifumi Hagiya
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Publication number: 20140087434Abstract: There is provided a method for producing an aqueous acrylamide solution by reacting a composition including acrylonitrile with water to produce acrylamide, in which the composition including acrylonitrile includes 3 to 15 mg of propionitrile per 1 kg of the total weight of the composition including acrylonitrile. According to the present invention, a production method with which it is possible to suppress acrylamide polymerization without lowering quality and thereby obtain a stable aqueous acrylamide solution can be provided.Type: ApplicationFiled: May 21, 2012Publication date: March 27, 2014Applicant: Mitsubishi Rayon Co., Ltd.Inventors: Makoto Kanou, Norifumi Hagiya
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Publication number: 20140051133Abstract: Provided herein are polypeptides having ketol-aid reductoisomerase activity as well as microbial host cells comprising such polypeptides. Polypeptides provided herein may be used in biosynthetic pathways, including, but not limited to, isobutanol biosynthetic pathways.Type: ApplicationFiled: May 10, 2013Publication date: February 20, 2014Applicant: BUTAMAX ADVANCED BIOFUELS, LLCInventors: Sridhar Govindarajan, Yougen Li, Der-Ing Liao, Daniel P. O'Keefe, Jeremy Stephen Minshull, Steven Cary Rothman, Alexander Vincent Tobias
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Patent number: 8647848Abstract: The invention relates to the enzymatic synthesis of sphingolipids and compositions that contain sphingolipids from lysosphingolipids and carbonic esters, and to cosmetic, dermatological or pharmaceutical formulations containing said sphingolipids or compositions.Type: GrantFiled: May 22, 2009Date of Patent: February 11, 2014Assignee: Evonik Goldschmidt GmbHInventors: Frank Hollmann, Oliver Thum, Christoph Toelle, Angelo Provinzano, Cornelis Gerrit Nijs Korevaar
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Publication number: 20140024088Abstract: Process for the enzymatic synthesis of the compound of formula (I), (7S)-1-(3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)N-methyl methanamine: and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.Type: ApplicationFiled: July 15, 2013Publication date: January 23, 2014Inventors: Sandrine PEDRAGOSA-MOREAU, François LEFOULON, Francisco MORIS VARAS, Javier GONZALEZ SABIN
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Publication number: 20130317109Abstract: There is provided a process for the preparation of Lacosamide (which is a useful medicament) of formula I, which comprises an enantioselective enzymatic acylation.Type: ApplicationFiled: November 25, 2011Publication date: November 28, 2013Applicant: CAMBREX KARLSKOGA ABInventors: Cecilia Kvarnström Branneby, Margus Eek
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Patent number: 8569012Abstract: The present invention provides a method for conveniently stabilizing an aqueous acrylamide solution using a stabilizer which can be separated and removed easily. In the method for stabilizing an aqueous acrylamide solution according to the present invention, a microbial cell is added to the aqueous acrylamide solution at a dried cell weight concentration of 1 to 14000 mg/L.Type: GrantFiled: March 12, 2009Date of Patent: October 29, 2013Assignee: Mitsubishi Rayon Co., Ltd.Inventors: Masahito Oda, Katsuo Ishii
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Publication number: 20130260426Abstract: The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (?)-2-[(R)-(diphenyl-methyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.Type: ApplicationFiled: December 7, 2011Publication date: October 3, 2013Inventors: Ee Lui Ang, Oscar Alvizo, Behnaz Behrouzian, Michael Clay, Steven Collier, Ellen Eberhard, Fan Jaslyn Fu, Shiwei Song, Derek Smith, Magnus Widegren, Robert Wilson, Junye Xu, Jun Zhu
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Publication number: 20130236935Abstract: In an alcohol fermentation process, oil derived from biomass is hydrolyzed into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation broth. The glycerides in the oil can be catalytically (e.g., enzymatically) hydrolyzed into free fatty acids, which form a fermentation product extractant having a partition coefficient for a product alcohol greater than a partition coefficient of the oil of the biomass for the product alcohol. Oil derived from a feedstock of an alcohol fermentation process can be hydrolyzed by contacting the feedstock including the oil with one or more enzymes whereby at least a portion of the oil is hydrolyzed into free fatty acids forming a fermentation product extractant, or the oil can be separated from the feedstock prior to the feedstock being fed to a fermentation vessel, and the separated oil can be contacted with the enzymes to form the fermentation product extractant.Type: ApplicationFiled: May 15, 2013Publication date: September 12, 2013Applicant: Butamax(TM) Advanced Biofuels LLCInventors: Keith H. Burlew, Robert Dicosimo, Michael Charles Grady
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Publication number: 20130224795Abstract: A method is provided for immobilizing a bioactive molecule onto a surface using polyphenol oxidase. In the presence of polyphenol oxidase, a bioactive molecule containing a phenol or catechol group can be simply in situ oxidized within a short time to dopa or dopaquinone which forms a coordinate bond with a metal or polymer substrate, thus immobilizing the bioactive molecule onto the surface with stability. Based on the surface immobilization of bioactive molecules using polyphenol oxidase, various bioactive molecules such as osteogenetic peptides and growth factors can be simply immobilized to medical metal or polymer substrate surfaces such as orthopedic or dental implants which can be then effectively used to induce rapid osteogenesis after being transplanted. Also, antithrombotic agents and/or entothelialization inducing agents may be immobilized to medical substrates for vascular systems, such as stents and artificial blood vessels, thus guaranteeing hemocompatibility to the medical substrates.Type: ApplicationFiled: August 19, 2011Publication date: August 29, 2013Applicant: Ajou University Industry-Academic Cooperation FoundationInventors: Ki-Dong Park, Kyung-Min Park, Yoon-Ki Joung, Yun-Ki Lee, Ji-Hye Oh, Seung-Mi Hyun
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Publication number: 20130217081Abstract: The invention relates to methods for enriching monomer content in a cycloalkane oxidation process mixed organic waste stream. In particular, the methods involve combining a biocatalyst with a mixed organic waste stream from a cycloalkane oxidation process, and enzymatically converting dimeric and/or oligomeric components of said waste stream into monomeric components. The methods may enrich the content of diacids, adipic acid, and/or other ?,?-difunctional C6 alkanes in the mixed organic waste stream. Additionally, the treated mixed organic waste streams may have improved burning efficiency.Type: ApplicationFiled: December 14, 2012Publication date: August 22, 2013Applicant: INVISTA NORTH AMERICA S.A. R.L.Inventor: Invista North America S.A. R.L.
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Publication number: 20130196013Abstract: Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and/or carboxylic acid containing compounds as active ingredients and/or compounds derived from Pseudomonas and/or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.Type: ApplicationFiled: March 15, 2013Publication date: August 1, 2013Applicant: MARRONE BIO INNOVATIONS, INC.Inventor: MARRONE BIO INNOVATIONS, INC.
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Publication number: 20130121978Abstract: Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and/or carboxylic acid containing compounds as active ingredients and/or compounds derived from Pseudomonas and/or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.Type: ApplicationFiled: December 17, 2012Publication date: May 16, 2013Applicant: MARRONE BIO INNOVATIONS, INC.Inventor: Marrone Bio Innovations, Inc.
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Publication number: 20130095535Abstract: The present invention is concerned with a process of preparing (R)-lacosamide. The process comprises providing an (R,S)-lacosamide precursor and contacting the same with at least an enzyme in the presence of a solvent. The enzyme either stereoselectively hydrolyzes or acetylates an (R)- or (S)-enantiomer of the (R,S)-lacosamide precursor. The process further comprises where appropriate also concurrently, or successively, employing one or more reagents capable of converting the hydrolysed or acetylated (R)- or (S)-enantiomer to (R)-lacosamide.Type: ApplicationFiled: June 15, 2011Publication date: April 18, 2013Applicant: MEDICHEM, S.A.Inventors: Jordi Bosch i Lladó, Ernesto Durán López
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Publication number: 20130078683Abstract: The present invention provides for a method of producing a cinnamoyl anthranilate, or analog thereof, in a genetically modified host cell.Type: ApplicationFiled: October 14, 2011Publication date: March 28, 2013Applicant: The Regents of the University of CaliforniaInventors: Dominique Loque, Aymerick Guillaume Eudes
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Publication number: 20130071886Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.Type: ApplicationFiled: August 3, 2012Publication date: March 21, 2013Applicant: GENOMATICA, INC.Inventors: Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Jun Sun
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Publication number: 20130059349Abstract: The present invention provides a more efficient method for producing acrylamide from acrylonitrile by the action of a microbially-derived enzyme, nitrile hydratase. More specifically, the present invention provides a method for producing acrylamide from acrylonitrile using a biocatalyst having nitrile hydratase, which comprises the step of keeping acrylonitrile while cooling to less than 30° C. Moreover, the present invention also provides an apparatus for producing acrylamide from acrylonitrile using a biocatalyst having nitrile hydratase.Type: ApplicationFiled: May 6, 2011Publication date: March 7, 2013Applicant: DIA-NITRIX CO., LTD.Inventors: Kozo Murao, Makoto Kano, Yuji Hirata
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Publication number: 20130059348Abstract: The present invention has its object to provide a novel polypeptide having amidase activity to selectively hydrolyze S-enantiomer in racemic nipecotamide, a DNA encoding the polypeptide, a vector containing the DNA, a transformant transformed with the vector, and a method for producing an optically active carboxylic acid amide and an optically active carboxylic acid in which a racemic carboxylic acid amide is hydrolyzed with the polypeptide or the transformant.Type: ApplicationFiled: March 14, 2008Publication date: March 7, 2013Applicant: Kaneka CorporationInventors: Masutoshi Nojiri, Daisuke Moriyama, Tozo Nishiyama, Naoaki Taoka
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Publication number: 20130048136Abstract: Disclosed is a copolyamide including at least two repeat units selected from the group consisting of structures (I) to (IV), —C(O)(CH2)10C(O)NH(CH2)nNH—??(I); —C(O)(CH2)12C(O)NH(CH2)nNH—??(II); —C(O)(CH2)14C(O)NH(CH2)nNH—??(II); and —C(O)(CH2)16C(O)NH(CH2)nNH—??(IV); and n is an integer selected from 4, 6, 10 or 12; wherein at least one repeat unit is selected from structures (I) and (II); and any one the repeat units may be present up to about 92 mole percent. Also disclosed is a process for providing the copolyamide; and thermoplastic compositions and tubing including the copolyamides.Type: ApplicationFiled: August 28, 2012Publication date: February 28, 2013Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: EKATERINI KOROVESSI, Anna Kutty Mathew, Marvin M. Martens, Joachim C. Ritter
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Patent number: 8372601Abstract: The disclosure of the present application provides polypeptide sequences and nucleotide sequences coding for the polypeptide sequences of proteins used in the production of APPA-containing peptides. In at least one embodiment of the present disclosure, an isolated nucleic acid is disclosed which comprises a nucleotide sequence encoding a polypeptide having a sequence identity of 60 percent or greater to an amino acid sequence selected from the group consisting of SEQ ID NOS: 2-13, and 15-23.Type: GrantFiled: January 21, 2011Date of Patent: February 12, 2013Assignee: University of Illinois at Urbana-ChampaignInventors: William W. Metcalf, Wilfred A. van der Donk, Junkal Zhang, Benjamin T. Circello, Svetlana A. Borisova
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Publication number: 20130022553Abstract: The present invention relates to novel polyamino polyketide antibiotics, methods of their production as well as methods of using these antibiotics, for example, for inhibition or removal of biofilm formation or for treating bacterial infection with these antibiotics.Type: ApplicationFiled: November 9, 2009Publication date: January 24, 2013Applicant: Agency for Science, Technology and ResearchInventors: Jien Wu, Haibao Zhang, Lianhui Zhang
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Publication number: 20130018124Abstract: A process for making biodegradable a synthetic polymeric material thanks to the addition of one or more yeasts to the synthetic material is disclosed.Type: ApplicationFiled: January 25, 2011Publication date: January 17, 2013Applicant: QUEENSBROOK LIMITEDInventor: Madrisano Catinari
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Patent number: 8349593Abstract: Disclosed is a novel process for producing a compound represented by the general formula (1) by using a microorganism, wherein the compound is useful as a plant growth stimulant. Specifically disclosed is a process for producing a succinic acid amide compound represented by the general formula (1) [wherein Ar represents a phenyl, naphthyl or indolyl group which may have a substituent; and n represents a numeral value ranging from 1 to 4] or a salt thereof, which is characterized by culturing a microorganism of the genus Pseudomonas that is capable of synthesizing a succinic acid amide in a culture medium containing an arylalkylamine represented by the general formula (2).Type: GrantFiled: October 24, 2008Date of Patent: January 8, 2013Assignee: Sumitomo Chemical Company, LimitedInventors: Toru Kitamura, Hiroshi Soejima, Tamizi Sugiyama
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Publication number: 20120329108Abstract: The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.Type: ApplicationFiled: September 5, 2012Publication date: December 27, 2012Applicant: CODEXIS, INC.Inventors: Christopher Savile, Emily Mundorff, Jeffrey C. Moore, Paul N. Devine, Jacob M. Janey
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Publication number: 20120329095Abstract: Provided is a method of producing succinic acid in which a microorganism having a succinic acid-producing ability is allowed to react with a sugar, the method being characterized in that the ratio of the oxygen transfer rate to the succinic acid production rate (mmol-O2/mol-SA) is 0.1 to 240 and that the doubling time of the microorganism during the reaction is not shorter than 40 hours.Type: ApplicationFiled: September 7, 2012Publication date: December 27, 2012Applicant: MITSUBISHI CHEMICAL CORPORATIONInventors: Katsunori YOSHIKAWA, Daisuke KIDO, Makoto MURASE
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Patent number: 8334119Abstract: The invention relates to the development of appropriate cultivation conditions for a bacteria to grow anaerobically (fermentatively) on a glycerol substrate. The method requires culturing bacteria having a functional 1,2-propanediol pathway and a functional type II glycerol dehydrogenase-dihydroxyacetone kinase pathway in a culture medium containing high concentrations of glycerol, a neutral to mildly acidic pII, low levels of potassium and phosphate, and high levels of CO2, such that glycerol is thus converted into a desirable product, such as ethanol, hydrogen, formate, succinate, or 1,2-propanediol.Type: GrantFiled: January 11, 2012Date of Patent: December 18, 2012Assignee: William Marsh Rice UniversityInventor: Ramon Gonzalez
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Patent number: 8329435Abstract: A “one-step” process for production of peptides and other organic molecules which are both esters and also acetylated forms of the desired molecule. The ester may be a mono-ester, di-ester, or another poly-ester, complexed with a molecule for protecting the organic molecules in the digestive tract. The method allows simple adjustment of the delivery properties of the peptides produced, in particular adjustment or addition of lipiphilic tendencies. A therapeutic or nutrient made by this method comprises acetylated organic molecule esters, in particular an acetylated peptide ester or even an acetylated amino acid ester and demonstrates improved metabolic properties leading to increased efficiency for therapeutic and cosmetic purposes including oral, transdermal, sublingual, buccal, and topical administration.Type: GrantFiled: September 24, 2010Date of Patent: December 11, 2012Assignee: American Symbolic, LLCInventor: Keith K. Skinner
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Patent number: 8329843Abstract: A method for producing an amide compound from a nitrile compound in an aqueous medium in the presence of a catalyst having a nitrile hydratase activity wherein the concentration of benzene in the aqueous medium is 4.0 ppm or less and a method for producing an amide-based polymer excellent in quality from the amide compound. Also provided are a method for more efficiently producing an acrylamide with higher quality by a microbial catalyst containing a nitrile hydratase and the like and a method for producing an acrylamide-based polymer, which is excellent in hue, has a good balance between water solubility and high molecular weight and is excellent in quality.Type: GrantFiled: August 3, 2011Date of Patent: December 11, 2012Assignee: Mitsui Chemicals, Inc.Inventors: Hiroko Shibamoto, Toshikazu Aikawa, Teruo Arii, Masanori Muramoto, Takeshi Fukuda, Kiyoshi Ito, Takeya Abe, Souichi Hazama
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Publication number: 20120276601Abstract: A method for producing acrylamide from acrylonitrile by a biocatalyst method, wherein both evaporation of acrylonitrile into a gas phase and damaging of a catalyst by stirring are prevented, is provided. In the present invention, the production of acrylamide from acrylonitrile by the biocatalyst method comprises feeding acrylonitrile into an aqueous medium comprising a microbial catalyst.Type: ApplicationFiled: December 21, 2010Publication date: November 1, 2012Applicant: Dia-Nitrix Co., Ltd.Inventors: Takamitsu Kariya, Hiroyasu Banba, Makoto Kano
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Patent number: 8263371Abstract: The claimed invention relates to a process for preparing (meth)acrylates of N-hydroxyalkylated amides, in which open-chain N-hydroxyalkylated amides are esterified with (meth)acrylic acid or transesterified with at least one (meth)acrylic ester in the presence of at least one heterogeneous catalyst selected from the group consisting of an inorganic salt and an enzyme.Type: GrantFiled: March 25, 2011Date of Patent: September 11, 2012Assignee: BASF AktiengesellschaftInventors: Frank Hoefer, Dietmar Haering
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Patent number: 8252564Abstract: The present invention relates to a novel Burkholderia multivorans, an amidase produced from the same, and a method for optical resolution of a racemic mixture using the same, and more particularly to a strain Burkholderia multivorans LG 31-3, an amidase having stereoselective substrate specificity, and a method for optical resolution of a racemic mixture using the same. The amidase produced from the novel Burkholderia multivorans LG 31-3 (KCTC 10920BP) according to the present invention can be useful to produce single enantiomer at a high optical purity since the racemic mixture may be easily optically resolved under enzyme reaction conditions of room temperature and normal pressure.Type: GrantFiled: April 5, 2007Date of Patent: August 28, 2012Assignee: LG Chem, Ltd.Inventors: Oh-Jin Park, Sang-Hyun Lee
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Patent number: 8247198Abstract: It has surprisingly been discovered that it is possible to use enzymes in deep eutectic solvents (DES). DES's are mixtures of a nitrogen salt or a metal salt and a strong hydrogen bond donor that can be mixed in proportions that form a eutectic point.Type: GrantFiled: September 22, 2008Date of Patent: August 21, 2012Assignee: Friedrich SriencInventors: Johnathan T. Gorke, Romas J. Kazlauskas, Friedrich Srienc
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Patent number: 8232081Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzymeA biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ?-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX, as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured.Type: GrantFiled: November 8, 2004Date of Patent: July 31, 2012Assignee: BASF SEInventors: R. Rogers Yocum, Thomas A. Patterson, Theron Hermann, Janice G. Pero
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Publication number: 20120190086Abstract: The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of ? chloroalcohols from ? chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.Type: ApplicationFiled: June 22, 2010Publication date: July 26, 2012Applicant: CODEXIS, INC.Inventors: Yong Koy Bong, Michael Vogel, Steven J. Collier, Vesna Mitchell, Jagadeesh Mavinahalli
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Publication number: 20120190746Abstract: The present invention relates to provide an aflatoxin production inhibitor that inhibits aflatoxin production specifically and efficiently, is highly safe, and is practical, and an efficient production method thereof; and a method for controlling aflatoxin contamination that uses the aflatoxin production inhibitor, specifically relating to an aflatoxin production inhibitor that includes at least one of a dioctatin represented by the following formula (I) and a derivative thereof, as an active ingredient: where, in the formula (I), R represents one of hydrogen and a methyl group.Type: ApplicationFiled: December 19, 2011Publication date: July 26, 2012Applicants: The University of Tokyo, Microbial Chemistry Research FoundationInventors: Shohei Sakuda, Keita Nakamura, Tetsuo Akiyama, Yoshikazu Takahashi, Yasuhiko Muraoka, Ikuko Kurata
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Publication number: 20120107885Abstract: The invention relates to the development of appropriate cultivation conditions for a bacteria to grow anaerobically (fermentatively) on a glycerol substrate. The method requires culturing bacteria having a functional 1,2-propanediol pathway and a functional type II glycerol dehydrogenase-dihydroxyacetone kinase pathway in a culture medium containing high concentrations of glycerol, a neutral to mildly acidic pH, low levels of potassium and phosphate, and high levels of CO2, such that glycerol is thus converted into a desirable product, such as ethanol, hydrogen, formate, succinate, or 1,2-propanediol.Type: ApplicationFiled: January 11, 2012Publication date: May 3, 2012Applicant: William Marsh Rice UniversityInventor: Ramon GONZALEZ
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Patent number: 8153406Abstract: A microorganism which is Rhodococcus rhodochrous strain NCIMB 41164 or a mutant thereof. A method of culturing the microorganism in a culture medium comprising urea or urea derivative is claimed. A nitrile hydratase obtainable from the microorganism is claimed. Also claimed is a process of preparing an amide from the corresponding nitrile wherein the nitrile is subjected to a hydration reaction in an aqueous medium in the presence of a biocatalyst selected from the group consisting of a microorganism which is a Rhodococcus rhodochrous strain NCIMB 41164, a mutant thereof and a nitrile hydratase obtainable from Rhodococcus rhodochrous strain NCIMB 41164 or a mutant thereof. Also claimed is a method of storing the Rhodococcus rhodochrous NCIMB 41164.Type: GrantFiled: July 8, 2009Date of Patent: April 10, 2012Assignee: Ciba Specialty Chemicals Water Treatments Ltd.Inventors: Jonathan Hughes, Yvonne Armitage, Jatinder Kullar, Stuart Greenhalgh
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Patent number: 8143033Abstract: A process for producing (meth)acrylamide using a microbial catalyst, wherein production steps can be simplified and production cost can be reduced. The process for producing (meth)acrylamide of the present involves (a) a step of allowing (meth)acrylonitrile to undergo hydration reaction by the use of a microbial catalyst containing nitrile hydratase in an aqueous medium to obtain a (meth)acrylamide reaction solution (I) and (b) a step of removing impurities from the reaction solution (I) to obtain a (meth)acrylamide aqueous solution (II), wherein the concentration of (meth)acrylamide in the reaction solution (I) obtained in the step (a) is higher than the concentration of (meth)acrylamide in the aqueous solution (II) obtained in the step (b) by 2 to 20% by weight.Type: GrantFiled: April 3, 2007Date of Patent: March 27, 2012Assignee: Mitsui Chemicals, Inc.Inventors: Takeya Abe, Takeshi Fukuda
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Publication number: 20120021469Abstract: The disclosure relates to engineered amidase polypeptides and processes of using the polypeptides for chiral resolution of amino acid amide compounds. The disclosure further relates to the polynucleotides that encode the engineered amidase polypeptides and related vectors, host cells, and methods for making the engineered amidase polypeptides.Type: ApplicationFiled: March 26, 2010Publication date: January 26, 2012Applicant: CODEXIS, INC.Inventors: Owen Gooding, Robert J. Jones, Gjalt Huisman, Jie Yang, Louis Clark
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Publication number: 20110312044Abstract: In an alcohol fermentation process, oil derived from biomass is chemically converted into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation broth. The glycerides in the oil can be chemically converted into a reaction product, such as fatty acids, fatty alcohols, fatty amides, fatty acid methyl esters, fatty acid glycol esters, and hydroxylated triglycerides, and mixtures thereof, which forms a fermentation product extractant having a partition coefficient for a product alcohol greater than a partition coefficient of the oil of the biomass for the product alcohol. Oil derived from a feedstock of an alcohol fermentation process can be chemically converting into the fermentation product extractant.Type: ApplicationFiled: June 17, 2011Publication date: December 22, 2011Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLCInventors: DOUGLAS ROBERT ANTON, JELENA CIRAKOVIC, BRUCE A. DINER, MICHAEL CHARLES GRADY, FRANCIS J. WOERNER
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Publication number: 20110312043Abstract: In an alcohol fermentation process, oil derived from biomass is hydrolyzed into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation broth. The glycerides in the oil can be catalytically (e.g., enzymatically) hydrolyzed into free fatty acids, which form a fermentation product extractant having a partition coefficient for a product alcohol greater than a partition coefficient of the oil of the biomass for the product alcohol. Oil derived from a feedstock of an alcohol fermentation process can be hydrolyzed by contacting the feedstock including the oil with one or more enzymes whereby at least a portion of the oil is hydrolyzed into free fatty acids forming a fermentation product extractant, or the oil can be separated from the feedstock prior to the feedstock being fed to a fermentation vessel, and the separated oil can be contacted with the enzymes to form the fermentation product extractant.Type: ApplicationFiled: June 17, 2011Publication date: December 22, 2011Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLCInventors: KEITH H. BURLEW, ROBERT DICOSIMO, MICHAEL CHARLES GRADY
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Publication number: 20110294171Abstract: The invention relates to a compound according to Formula (IX) and salts thereof, wherein R1, R2 and R5 are each independently selected from H and hydrocarbon moieties, which hydrocarbon moieties optionally comprise one or more heteroatoms, and which hydrocarbons optionally comprise substituents, or when the compound according to formula (IX) is a salt, R1 and/or R2 may be a cation, R3, and R4 each independently selected from hydrocarbon moieties, which hydrocarbon moieties optionally comprise one or more heteroatoms, and which hydrocarbons optionally comprise substituents, and wherein any two of R1, R2, R3, R4 and R5 are optionally linked together to form a ring structure. The invention further relates to the preparation of such a compound and to the use of such a compound for preparing a pharmaceutical compound, an agrochemical compound, an intermediate for a pharmaceutical compound or an intermediate for an agrochemical compound.Type: ApplicationFiled: August 8, 2011Publication date: December 1, 2011Applicant: DSM IP Assets B.V.Inventors: Gerardus Karel Maria Verzijl, Henricus Martinus Maria Gerardus Straatman, Andreas Hendrikus Maria De Vries, Lizette Schmieder, Jeroen Antonius Franciscus Boogers
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Publication number: 20110288255Abstract: A method for producing an amide compound from a nitrile compound in an aqueous medium in the presence of a catalyst having a nitrile hydratase activity wherein the concentration of benzene in the aqueous medium is 4.0 ppm or less and a method for producing an amide-based polymer excellent in quality from the amide compound. Also provided are a method for more efficiently producing an acrylamide with higher quality by a microbial catalyst containing a nitrile hydratase and the like and a method for producing an acrylamide-based polymer, which is excellent in hue, has a good balance between water solubility and high molecular weight and is excellent in quality.Type: ApplicationFiled: August 3, 2011Publication date: November 24, 2011Applicant: MITSUI CHEMICALS, INC.Inventors: Hiroko Shibamoto, Toshikazu Aikawa, Teruo Arii, Masanori Muramoto, Takeshi Fukuda, Kiyoshi Ito, Takeya Abe, Souichi Hazama
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Patent number: 8062870Abstract: Methods of enzymatically resolving acyloxyalkyl thiocarbonates useful in the synthesis of acyloxyalkyl carbamate prodrugs are disclosed.Type: GrantFiled: January 23, 2009Date of Patent: November 22, 2011Assignee: XenoPort, Inc.Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Ge Peng, Stephen P. Raillard
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Publication number: 20110245321Abstract: The present invention relates to methods of inhibiting S. aureus comprising inhibiting siderophore-mediated iron uptake, for example, staphyloferrm-mediated iron uptake Such methods of inhibiting S. aureus include the inhibition of staphyloferrm A- and staphyloferrm B-mediated uptake either by inhibiting expression or activity of staphyloferrm A and B or by inhibiting transport of staphyloferrm A and B The methods as provided would be useful for treating S.Type: ApplicationFiled: August 14, 2009Publication date: October 6, 2011Inventors: David E. Heinrichs, Federico Beasley, Enríque Vines, Johnson Cheung
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Publication number: 20110244531Abstract: The invention relates to a process for the preparation of compounds that are important building blocks in convergent synthesis routes to 2(S),4(S),5(S),7(S)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides or pharmaceutically acceptable salts thereof, such as the compound Aliskiren, and to a process for the preparation of these octanoyl amides, comprising reacting said building block.Type: ApplicationFiled: July 23, 2009Publication date: October 6, 2011Inventors: Andreas Hendrikus Maria De Vries, Gerardus Karel Maria Verzijl, Petrus Johannes Hermsen, Anna Maria Cornelia Francisca Castelijns