Binds A Hormone Or Other Secreted Growth Regulatory Factor, Differentiation Factor, Intercellular Mediator, Or Neurotransmitter (e.g., Insulin, Human Chorionic Gonadotropin, Intragonadal Regulatory Protein, Mullerian Inhibiting Substance, Inhibin, Epidermal Growth Factor, Nerve Growth Factor, Dopamine, Norepinephrine, Etc.) Patents (Class 435/336)
  • Hybridomas producing antibodies to cardiac hypertrophy factor
    Patent number: 5627073
    Abstract: Isolated CHF (also referred to cardiac hypertrophy factor or cardiotrophin-1), isolated DNA encoding CHF, hybridomas and cell lines producing antibodies to CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: May 6, 1997
    Assignees: Genentech, Inc., The Regents of the University of California
    Inventors: Joffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
  • Method and monoclonal antibodies for vitamin B12 determination
    Patent number: 5614394
    Abstract: A method for making an monoclonal antibody specific for vitamin B12 by immunizing mice with vitamin B12-b-acid and isolating hybridomas that produce monoclonal antibodies which have an affinity constant for B12 greater than 5.times.10.sup.9 l/mol is disclosed.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: March 25, 1997
    Assignee: Boehringer Mannheim GmbH
    Inventors: Nicholas R. Hoyle, Gunter Pappert, Michael Grol, Christa Hubner-Parajsz
  • Cadherin-specific antibodies and hybridoma cell lines
    Patent number: 5597725
    Abstract: DNA sequences encoding novel cadherins, desginated cadherins-4 through -12, are disclosed along with methods and materials for the recombinant production of the same. Antibody substances specific for the novel cadherins and cadherin peptides are disclosed as useful for modulating the natural binding and/or regulatory activities of the cadherins.
    Type: Grant
    Filed: January 26, 1994
    Date of Patent: January 28, 1997
    Assignee: Doheny Eye Institute
    Inventor: Shintaro Suzuki