Lactobacillus Brevis Patents (Class 435/855)
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Patent number: 8889119Abstract: This disclosure relates to enhancing growth and/or activity of lactobacilli using a prebiotic formulation which includes iso-malto oligosaccharides and ?-galactosidase; and to enhancing growth and/or activity of bifidobacteria using a prebiotic formulation which includes iso-malto oligosaccharides and ?-glucanase. Other combinations of fibers and enzymes are described below which also stimulate growth and activity of lactobacilli or bifidobacteria. These combinations of enzymes and prebiotics can be taken separately or added to foods, including desserts.Type: GrantFiled: September 7, 2013Date of Patent: November 18, 2014Assignee: Master Supplements, Inc.Inventors: Randolph S. Porubcan, Sonja L. Yonak
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Patent number: 8722035Abstract: Disclosed are formulations for enhancing the in vivo colonization of probiotic microorganisms that include digestive enzymes and probiotic microorganisms, and polysorbate surfactants. The enzymes include lactogenic enzyme formulations that promote growth of Lactobacillus probiotics, bifidogenic enzyme formulations that promote growth of Bifidobacterium probiotics and combination formulations that benefit both types of probiotics. It has been discovered that certain polysorbate surfactants, including polysorbate-60 and polysorbate-80, further promote probiotic microorganism growth, when used with the enzyme formulations. The formulations are preferably compounded as dry powders, to avoid water reaction with the enzymes in blended formulations. Such formulations can be contained in capsules, tablets, packets or bottles and administered orally, either sequentially or in one combined formulation.Type: GrantFiled: October 6, 2011Date of Patent: May 13, 2014Assignee: Master Supplements, Inc.Inventor: Randolph S. Porubcan
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Patent number: 8066986Abstract: Disclosed are formulations for enhancing the in vivo colonization of probiotic microorganisms that include digestive enzymes and probiotic microorganisms, and polysorbate surfactants. The enzymes include lactogenic enzyme formulations that promote growth of Lactobacillus probiotics, bifidogenic enzyme formulations that promote growth of Bifidobacterium probiotics and combination formulations that benefit both types of probiotics. It has been discovered that certain polysorbate surfactants, including polysorbate-60 and polysorbate-80, further promote probiotic microorganism growth, when used with the enzyme formulations. The formulations are preferably compounded as dry powders, to avoid water reaction with the enzymes in blended formulations. Such formulations can be contained in capsules, tablets, packets or bottles and administered orally, either sequentially or in one combined formulation.Type: GrantFiled: January 30, 2008Date of Patent: November 29, 2011Assignee: Master Supplements, Inc.Inventor: Randolph S. Porubcan
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Patent number: 7384628Abstract: A composition comprising lactic acid bacteria that are selected from at least one of Lactococcus lactis, Lactobacillus lactis, and Lactobacillus brevis. The composition is suitable for administration to animals. Upon administration to an animal, the composition provides at least one of the following (a) improves performance in the animal and (b) reduces scours in animals. Also provided is a method of treating an animal in which the composition is administered to the animal. A method of forming a direct-fed microbial is also provided. A culture including the lactic acid bacteria is grown in a liquid nutrient broth. The lactic acid bacteria are separated from the liquid nutrient broth. The lactic acid bacteria can be freeze dried.Type: GrantFiled: June 23, 2004Date of Patent: June 10, 2008Assignees: Agtech Products, Inc., Merrick's, Inc.Inventors: Thomas G. Rehberger, Elizabeth A. Galbraith
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Patent number: 7052688Abstract: The disclosure is of a combination of lactic acid bacteria comprising: (a) a first component consisting of at least one strain of H2O2-producing lactic acid bacteria; and (b) a second component consisting of at least one strain of arginine-utilizing lactic acid bacteria. The disclosure is also of the use of this combination for making a food supplement, a hygiene product or a pharmaceutical preparation for the prevention and/or treatment of infections and inflammatory conditions caused by bacteria, viruses or fungi, especially in the mouth, vagina, urethra, nose, eyes and ears.Type: GrantFiled: December 21, 2001Date of Patent: May 30, 2006Assignee: VSL Pharmaceuticals, Inc.Inventor: Claudio De Simone
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Patent number: 6664100Abstract: A method for converting organic solid waste into humic products and the corresponding apparatus, in which a preliminary aerobic fermentation of the organic solid waste is performed, followed by a second aerobic fermentation of the organic waste in the presence of specific microorganisms in order to provide a basic precursor on which the selective metabolization occurs of specific bacterial strains to provide the humic product.Type: GrantFiled: February 25, 1999Date of Patent: December 16, 2003Inventor: Riccardo Reverso
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Patent number: 6582695Abstract: The use of sphingomyelinase to increase the levels of skin and mucosal ceramides, as well as dermatological and cosmetic compositions containing same which are suitable for topical application are disclosed.Type: GrantFiled: May 22, 2001Date of Patent: June 24, 2003Assignee: VSL Pharmaceuticals Inc.Inventors: Renata Maria Anna Cavaliere Vesely, Claudio De Simone
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Publication number: 20020012980Abstract: Disclosed are methods for bioconversion of cellulose in spent sausage casings to a useful end-product. The methods involve treating the cellulose with a cellulase to yield glucose, which in turn is converted to lactic acid, ethanol, enzymes or feed grade protein by a microorganism.Type: ApplicationFiled: July 25, 2001Publication date: January 31, 2002Applicant: Wisconsin Alumni Research FoundationInventor: Hassan K. Sreenath
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Patent number: 6340585Abstract: The present invention relates to a novel defined medium suitable to cultivate lactic acid bacteria, such as Lactobaccilus or Bifidobacteria. In particular the present invention pertains to the use of said medium for the isolation of bioactive molecules or functional metabolites.Type: GrantFiled: March 22, 2000Date of Patent: January 22, 2002Assignee: Nestec S.A.Inventors: Marina Elli, Ralf Zink, Barbara Marchesini-Huber, Roberto Reniero
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Patent number: 6051552Abstract: The present invention is directed towards isolated lactobacillus biosurfactants and the process for producing same. The present invention is also directed to methods for preventing urogenital infection in mammals using the isolated lactobacillus biosurfactant. The present invention is further directed to methods of inhibiting microbial biofilm formation using the isolated lactobacillus biosurfactant to prevent the formation of bacterial biofilms, and to displace adherent biofilm-forming bacteria from surfaces.Type: GrantFiled: May 30, 1997Date of Patent: April 18, 2000Assignee: Urex Biotech, Inc.Inventors: Gregor Reid, Andrew W. Bruce, Henk J. Busscher, Henny C. Van der Mei
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Patent number: 6022537Abstract: Bacterial strains of genus Bacillus closely phenotypically related to genus Lactobacillus. The strains are moderately thermophilic, have amylolytic properties and/or are capable of producing L(+) lactate, and are useful for producing metabolites such as L(+) lactate.Type: GrantFiled: January 10, 1996Date of Patent: February 8, 2000Assignee: Institut Francais de Recherche Scientifique pour le Developpement en Cooperation (Orstom)Inventors: Yannick Combet-Blanc, Bernard Ollivier, Jean-Louis Garcia
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Patent number: 5849565Abstract: A biomass constituted of yeast and of lactic acid bacteria, which can be used directly as panification ferment without previous separation of the culture medium and the biomass, is prepared by cocultivating at least one strain of yeast and at least one strain of lactic acid bacteria in a mixed and/or sequential culture, in a culture medium specified in the description. Preferably, the said ferment comprises as yeast the strain Saccharomyces cerevisiae steineri DSM 9211 and as lactic acid bacteria one or several strains of Lactobacillus brevis DSM 9209, Lactobacillus plantarum DSM 9208, Leuconostoc mesenteroides DSM 9207 and/or Pediococcus pentosaceus DSM 9210.Type: GrantFiled: October 10, 1997Date of Patent: December 15, 1998Assignee: Agrano AGInventor: Aloyse Ehret
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Patent number: 5804179Abstract: This invention relates to lactobacillus compositions and methods of employing said compositions for treating or preventing urinary tract infections. More particularly, this invention relates to the ability of certain strains of lactobacilli to adhere to uroepithelial or vaginal epithelial cells and to exhibit inhibitory activity against the growth of pathogenic bacteria.Type: GrantFiled: September 30, 1994Date of Patent: September 8, 1998Assignee: Research Corporation Technologies, Inc.Inventors: Andrew W. Bruce, Gregor Reid
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Patent number: 5753471Abstract: A process for the biotechnological preparation of alcohols, aldehydes and carboxylic acids by oxidation of compounds of the formula R.sup.1 --C(CH.sub.3).dbd.CR.sup.2 R.sup.3, where R.sup.1, R.sup.2 and R.sup.3 have the meanings indicated in the description, with the aid of microorganisms is described.Type: GrantFiled: December 28, 1995Date of Patent: May 19, 1998Assignee: BASF AktiengesellschaftInventors: Uwe Pressler, Friedhelm Balkenhohl, Bernhard Hauer, Wolfgang Ladner, Ursula Schnell, Horst Ralf Staudenmaier
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Patent number: 5662900Abstract: A composition containing powdered Lactobacillus brevis subsp. coagulans is used to enhance the immunological functions of a patient, particularly with respect to increasing interferon production, 2-5A synthetase activity and Natural Killer activity.Type: GrantFiled: June 19, 1996Date of Patent: September 2, 1997Assignees: Institut Pasteur De Kyoto, Shinwa Pharmaceutical Co., Ltd., Nitto Pharmaceutical Industries, Ltd.Inventor: Tsunataro Kishida
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Patent number: 5645830Abstract: This invention relates to Lactobacillus, skim milk, Lactobacillus Growth Factor (LGF) and Lactobacillus compositions and methods of employing the compositions for preventing urogenital infections. More particularly, this invention relates to the ability of strains of hydrophobic or hydrophilic Lactobacillus to adhere to biomaterials, and intestinal, vaginal and uroepithelial cells, to resist the action of certain antimicrobial agents and to dominate the urogenital flora.Type: GrantFiled: September 19, 1994Date of Patent: July 8, 1997Assignee: Research Corporation Technologies, Inc.Inventors: Gregor Reid, Andrew W. Bruce
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Patent number: 5556785Abstract: A composition containing powdered Lactobacillus brevis subsp. coagulans is used to enhance the immunological functions of a patient, particularly with respect to increasing interferon production, 2-5A synthetase activity and Natural Killer activity.Type: GrantFiled: October 27, 1993Date of Patent: September 17, 1996Assignees: Institut Pasteur de Kyoto, Shinwa Pharmaceutical Co., Ltd., Nitto Pharmaceutical Industries Ltd.Inventor: Tsunataro Kishida
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Patent number: 5283069Abstract: Aroma and/or flavor materials for use in baking such as in making sourdough bread are produced by culturing lactic acid bacteria in an aqueous dispersion of an expanded, pregelatinized, starch-containing cereal adsorbent. The cereal adsorbent is obtained by extrusion of a cereal product under a pressure of less than 50 bar at a temperature of at least 150.degree. C. A 10 wt% dispersion of the cereal adsorbent has a viscosity at 25.degree. C. of about 30 to about 60 mPas. After culturing, a concentrate substantially free from insoluble matter is separated. The concentrate is separated by centrifugation into a cell concentrate and a clarified broth containing the aroma and/or flavor materials. The lactic acid bacteria are adsorbed in situ onto the cereal adsorbent during culturing. Insoluble residue separated after culturing contains supported lactic acid bacteria that can be used in making sourdough bread. If necessary, the supported bacteria can be dried for storage before use.Type: GrantFiled: August 19, 1992Date of Patent: February 1, 1994Assignee: Unilever Patent Holdings B.V.Inventors: Wietse Van Dijk, Bartholomeus J. Van Schie, Nigel K. H. Slater
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Patent number: 5252473Abstract: Processes are disclosed for producing lactic acid, esters of lactic acid, acrylic acid, and esters of acrylic acid, primarily from fermentable carbohydrate materials. An overall process for producing esters of acrylic acid comprises: a) fermenting carbohydrate material with a lactic-acid-forming organism in the presence of NH.sub.3 to produce ammonium lactate; b) combining the ammonium lactate with an alcohol; c) combining the ammonium lactate and alcohol with an effective catalyzing amount of gaseous CO.sub.2 to catalytically esterify the ammonium lactate and alcohol into a lactic acid ester containing solution; d) recovering purified lactic acid ester; and e) vaporizing the lactic acid ester and passing it through a solid catalyst bed comprised of an effective catalyzing amount of crystalline hydrated and partially calcined calcium sulfate to catalytically convert lactic acid ester into an acrylic acid ester. Step "d" would be useful in a process for making low-cost, purified lactic acid.Type: GrantFiled: September 23, 1991Date of Patent: October 12, 1993Assignee: Battelle Memorial InstituteInventors: Paul C. Walkup, Charles A. Rohrmann, Richard T. Hallen, David E. Eakin
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Lactic acid bacteria cultures supported on an expanded cereal for preparing flavor or aroma material
Patent number: 5211971Abstract: Supported lactic acid bacteria are produced by culturing lactic acid bacteria in a medium containing an aqueous dispersion of an expanded, pre-gelatinized, starch containing cereal adsorbent obtained by extrusion of a cereal product under a pressure of less than 50 bar at a temperature of at least 150.degree. C. The dispersion has a viscosity at 25.degree. C. of from 30 to 60 mPas when measured as a 10% aqueous dispersion. After culturing, the supported bacteria are separated from the medium and the medium may be recovered as flavor or aroma material for use in baking. In another embodiment, the supported lactic acid bacteria are cultured in a medium to produce a flavor or aroma material.Type: GrantFiled: August 19, 1992Date of Patent: May 18, 1993Assignee: Unilever Patent Holdings B.V.Inventors: Wietse Van Dijk, Bartholomeus Van Schie, Nigel K. H. Slater -
Patent number: 5204247Abstract: A new strain Lactobacillus sp. KPB-176, which does not possess strict selectivity for specific media and which involves no reduction in the productivity of polysaccharides even during subculture, was isolated from kefir grains. When this new strain is cultured on a medium containing milk whey and casamino acid or when on a medium containing carbohydrate and yeast extract, capsular polysaccharides are produced in high yields.Type: GrantFiled: October 30, 1991Date of Patent: April 20, 1993Assignee: Sumitomo Heavy Industries, Ltd.Inventors: Susumu Adachi, Takahiro Toba, Takao Mukai, Takashi Watanabe, Haruhiko Yokoi
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Patent number: 5164314Abstract: A process for the enzymatic preparation of acetoin, particularly (+)-acetoin, employs a diacetyl reductase which can be obtained from a yeast or Lactobacillus strain.Type: GrantFiled: June 18, 1991Date of Patent: November 17, 1992Assignee: Forschungszentrum Juelich GmbHInventors: Werner Hummel, Maria R. Kula, Frank Boermann
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Patent number: 4226940Abstract: A concentrated bacterial culture, capable of being cooled to temperatures as low as about -40.degree. C. for storage without rapid freezing and with minimum damage to the bacterial cells, is prepared by diluting a conventionally prepared concentrated cell paste with a liquid anti-freeze agent containing one or more water freezing point depressants which are water-soluble, are non-injurious to the bacteria, and do not form crystals when cooled to a predetermined temperature within the range of about 5 to about -40.degree. C. The amount of the freezing point depressant(s) is sufficient to prevent formation of ice crystals from the water present in the diluted product when cooled to the predetermined temperature. The culture, which does not become hard or crystalline upon being cooled to temperatures as low as -40.degree. C., can be warmed to a temperature convenient for sampling, assaying and blending and then re-cooled to a cold storage temperature without an appreciable reduction in viability.Type: GrantFiled: June 21, 1979Date of Patent: October 7, 1980Assignee: Great Lakes Biochemical Co., Inc.Inventor: Arnold B. Storrs