Organic (e.g., Chemical Warfare Agents, Insecticides, Etc.) Patents (Class 436/104)
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Patent number: 8173431Abstract: A multi-tier approach for use in a mailroom for detecting bio-threats conveyed by mail. In a first tier procedure, mail entering the mailroom is continuously automatically screened at a mail screening station to detect a potential bio-threat contamination. If a potential bio-threat is detected, an alarm signal is generated, a sample of the potential bio-threat is collected, and a second tier procedure is initiated. The second tier procedure uses a manual test, such as a nucleic acid amplification and detection assay to detect any of a plurality of different specific bio-threats in the sample. If a specific bio-threat is found, appropriate steps are taken to limit spread of the bio-threat and exposure of personnel. A third tier procedure uses a manual assay to check for a specific toxin in background samples collected over a predefined time interval at each mail screening station and in the air handling system for the mailroom.Type: GrantFiled: November 9, 2006Date of Patent: May 8, 2012Assignee: FLIR Systems, Inc.Inventor: Charles J. Call
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Patent number: 8148161Abstract: Disclosed herein is a composition having: a polymer having a carbosilane or siloxane backbone and pendant hydrogen-bond acidic groups; and a filler material having polar groups. The polymer is not covalently bound to the filler material.Type: GrantFiled: May 1, 2009Date of Patent: April 3, 2012Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Bernadette A. Higgins, Duane L. Simonson, Viet Nguyen, Jennifer L. Stepnowski, R Andrew McGill
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Patent number: 8143063Abstract: A paint that warns of radiological or chemical substances comprising a paint operatively connected to the surface, an indicator material carried by the paint that provides an indication of the radiological or chemical substances, and a thermo-activation material carried by the paint. In one embodiment, a method of warning of radiological or chemical substances comprising the steps of painting a surface with an indicator material, and monitoring the surface for indications of the radiological or chemical substances. In another embodiment, a paint is operatively connected to a vehicle and an indicator material is carried by the paint that provides an indication of the radiological or chemical substances.Type: GrantFiled: July 16, 2010Date of Patent: March 27, 2012Assignee: Lawrence Livermore National Security, LLCInventors: Joseph C. Farmer, James L. Brunk, S. Daniel Day
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Patent number: 8133735Abstract: A system for warning of corrosion, chemical, or radiological substances. The system comprises painting a surface with a paint or coating that includes an indicator material and monitoring the surface for indications of the corrosion, chemical, or radiological substances.Type: GrantFiled: July 16, 2010Date of Patent: March 13, 2012Assignee: Lawrence Livermore National Security, LLCInventor: Joseph C. Farmer
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Publication number: 20120058565Abstract: Conjugates of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes with a variety of conjugating members are used in the formation of dinuclear metal complexes which bind to phosphate esters. By virtue of their conjugated forms, the complexes are incorporated into chromatographic media, affinity binding reagents, and dyes, which make the complexes useful in a wide range of assays, separations, and purifications. In addition, dinuclear metal complexes of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes that are not so conjugated are used in the detection of phosphate esters of biological species by either MALDI-TOF mass spectrometry or by dye displacement.Type: ApplicationFiled: March 9, 2011Publication date: March 8, 2012Applicant: BIO-RAD LABORATORIES, INC.Inventors: Thomas R. Berkelman, Lisandra Martin, Rhiannon Jones, John Walker, II
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Patent number: 8124420Abstract: A reagent for detecting and identifying a chemical substance. The reagent is an emulsion including a cobalt salt dissolved in water which also includes at least one organic solvent that is at least partly water-miscible and also including an organic compound which serves as an ion pair color changing indicator or a pH sensitive color changing indicator, the organic compound dissolved in an organic solvent only partly miscible with water. A two product kit for detecting and identifying a chemical substance is also taught. The kit includes the aforementioned reagent and a diazonium salt, typically a diazonium salt having electron withdrawing groups on its phenyl rings. A method for detecting and identifying a chemical substance using the two product kit is also discussed. The reagent, testing kit and method may be used for detecting and identifying controlled substances.Type: GrantFiled: August 21, 2008Date of Patent: February 28, 2012Assignee: Mistral Detection LtdInventor: Shai Amisar
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Publication number: 20120045840Abstract: Applicants have produced a chromophore and a polymer that are highly sensitive to the presence of various agents, including organophosphates, pesticides, neurotoxins, metal ions, some explosives, and biological toxins. The detection is accomplished by detecting a change in the fluorescence characteristics of the chromophore or polymer when in the presence of the agent to be detected. The chromophore and polymer may be incorporated into sensors of various types, and they are adaptable for potential field use in areas where detection of these types of agents is desired.Type: ApplicationFiled: February 7, 2011Publication date: February 23, 2012Applicant: NDSU-RESEARCH FOUNDATIONInventors: Johnson Thomas, Philip Boudjouk
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Patent number: 8093060Abstract: A compound which captures a multisite phosphorylated peptide or protein specifically to a phosphorylation site and a method for detecting the peptide or protein using the compound. Particularly, a compound which specifically detects an excessively phosphorylated tau protein observed in the brain affected by Alzheimer's disease and a method for diagnosing Alzheimer's disease in vitro or in vivo using the compound are provided. By bringing a metal complex compound having two dipicolylamine (Dpa) moieties and a spacer including a chromogenic or luminescent functional or atom group into contact with a multisite phosphorylated peptide or protein, the compound recognizes the distance between phosphate groups and specifically binds to the peptide or protein, and a multisite phosphorylated peptide or protein or kinase activity is optically detected by measuring the change, or a multisite phosphorylated peptide or protein or kinase activity is imaged by an optical imaging method applying the change in luminescence.Type: GrantFiled: February 25, 2009Date of Patent: January 10, 2012Assignee: Canon Kabushiki KaishaInventors: Itaru Hamachi, Fumio Yamauchi, Tetsuya Yano, Kimihiro Yoshimura, Akio Ojida, Takashi Sakamoto, Masaaki Inoue
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Patent number: 8076150Abstract: Methods and apparatus for chemical warfare agent detection training are provided. More particularly, methods and apparatus are provided to simulate the detection of low volatility chemical warfare agents by simulating the use of currently fielded U.S. Army detection kits without exposure to hazardous agents. A simulant is disposed in a sample heating assembly. The sample heating assembly is placed over a detection window of a detector, and the simulant is heated in order to make a simulated detection.Type: GrantFiled: June 30, 2010Date of Patent: December 13, 2011Assignee: The United States of America as represented by the Secretary of the ArmyInventor: James A. Genovese
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Patent number: 8057761Abstract: An embodiment of a chemical detector has at least one detection window and at least first and second ampoules selectively communicatively coupled to the at least one detection window. The first ampoule contains a first substance that can hydrolyze a nerve agent. The second ampoule contains a second substance that can react with a hydrolyzed nerve agent to produce a color change.Type: GrantFiled: December 13, 2006Date of Patent: November 15, 2011Assignee: The United States of America as represented by the Secretary of the ArmyInventors: James A. Genovese, Robin L. Matthews, Kwok Y. Ong
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Publication number: 20110275161Abstract: The teachings provided herein are directed to compounds and methods for detecting nerve agents using rhodamine-derived detection compounds. A rhodamine-derived detection compound for nerve agents can include any rhodamine derivative that can bind to a nerve agent and produce a detectable signal for detection of the nerve agent. In some embodiments, the rhodamine-derived detection compound comprises rhodamine B-hydroxamate and the nerve agent can be detected in amounts as low as about 10 ppm.Type: ApplicationFiled: May 5, 2010Publication date: November 10, 2011Applicant: MCLABInventors: SHOUFA HAN, Changping Shi
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Publication number: 20110244585Abstract: A device is disclosed for detecting at least one chemical compound comprising at least one carbon nanotube with several graphene layers, on which is grafted at least one molecule bearing group G1 capable of reacting with the chemical compound or a precursor of such a group G1. The uses and the method of making such a device is also disclosed.Type: ApplicationFiled: September 28, 2009Publication date: October 6, 2011Applicant: Commissariat a l'energie atomique et aux energies alternativesInventors: Martine Mayne-L'Hermite, Serge Palacin, Pascale Chenevier, Jérôme Chancolon, Aurélien Gohier
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Publication number: 20110207114Abstract: The present disclosure is related to amplified fluorescence polymers (AFPs) with pendant functional groups, their derivatives and their synthesis. The amplified fluorescence polymers can be used in various biological and chemical sensors.Type: ApplicationFiled: October 29, 2009Publication date: August 25, 2011Applicants: INDIAN INSTITUTE OF TECHNOLOGY MUMBAI, BIGTEC PRIVATE LIMITEDInventors: Anil Kumar, Jasmine Sinha, Phani Kumar Pullela
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Patent number: 8003398Abstract: The present invention provides various methods and compositions which allow for determining the presence or amount of glyphosate, N-acetylglyphosate, N-acetyl AMPA or aminomethyl phosphoric acid (AMPA) and its various metabolites in a variety of test matrices. In one method, determining the presence or amount of N-acetylglyphosate and/or N-acetyl AMPA in a test sample comprises providing the test sample suspected of containing N-acetylglyphosate and/or N-acetyl AMPA; extracting the N-acetylglyphosate and/or N-acetyl AMPA from the test sample; and, detecting the N-acetylglyphosate and/or N-acetyl AMPA in the extract. In other methods, the presence or amount of at least one of glyphosate, N-acetylglyphosate, N-acetyl AMPA or aminomethyl phosphonic acid (AMPA) or a metabolite thereof in a test sample is determined.Type: GrantFiled: March 19, 2008Date of Patent: August 23, 2011Assignee: E.I. de Pont de Nemours and CompanyInventors: Frederick Q. Bramble, Jr., Anne M. Pentz
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Publication number: 20110144064Abstract: Provided herein are methods of decreasing a level of kynurenic acid in a cell and of treating a pathophysiological condition in a subject associated with an increase in kynurenic acid in a subject. In these methods the inhibitory action of dicarboxylic acids or derivatives or analogs thereof are effective to inhibit activity of kynurenine aminotransferase II. Also provided is a method of screening for potential inhibitory compounds for kynurenine aminotransferase II. The dicarboxylic acids or derivatives or analogs thereof may have the structural formula, where R1 is H, NH2 or NHCH3, R2 is H or CH3, n is 0 to 14, and X is —COOH, CH2OH, —PO3H2, —SO3H, or —SO3H; or a pharmacologically acceptable salt.Type: ApplicationFiled: November 30, 2006Publication date: June 16, 2011Inventors: Robert Schwarcz, Roberto Pellicciari, Timothy Gately
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Patent number: 7951607Abstract: The present invention provides methods and compositions for detecting, identifying and measuring the abundance of chemical nerve agents. Methods and compositions of the present invention are capable of providing selective detection of phosphorous based nerve agents, such as nerve agents that are esters of methyl phosphonic acid derivatives incorporating a moderately good leaving group at the phosphorus. Selectivity in the present invention is provided by a sensor composition having an alpha (?) effect nucleophile group that undergoes specific nucleophilic substitution and rearrangement reactions with phosphorus based nerve agents having a tetrahederal phosphorous bound to oxygen. The present invention includes embodiments employing a sensor composition further comprising a reporter group covalently linked to the alpha effect nucleophile group allowing rapid optical readout of nerve agent detection events, including direct visual readout and optical readout via spectroscopic analysis.Type: GrantFiled: January 21, 2010Date of Patent: May 31, 2011Assignee: University of WyomingInventors: Robert C. Corcoran, Aaron D. Strickland
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Patent number: 7943394Abstract: The present invention provides a method for capacitive detection of the presence of target sample on a substrate, which comprises the steps of: binding a target sample to selective binding sites on the substrate, the target sample being directly or indirectly labeled with conductive labels, and sensing the presence of the bound conductive labels to a binding site to thereby determine the presence of the target sample. The sensing step is carried out by a capacitive detection of the presence of the conductive labels. The present invention also provides a capacitive sensor device for determining the presence of a target sample. Conductive labels are directly or indirectly couplable to the target sample.Type: GrantFiled: June 24, 2003Date of Patent: May 17, 2011Assignee: Université Catholique de LouvainInventors: Denis Flandre, Luis Moreno Hagelsieb, Rémi Pampin, David Bourgeois, José Remacle, Pierre-Emmannuel Lobert
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Patent number: 7939337Abstract: This invention relates generally to a new class of chemoselective polymer materials primarily designed to sorb hydrogen bond basic analytes such as organophosphonate esters (nerve agents and precursors) and nitro-substituted compounds (explosives). In particular, the invention relates to linear polycarbosilane compounds for use in various analytical applications involving sorbent polymer materials, including chromatography, chemical trapping, analyte collection, and chemical sensor applications.Type: GrantFiled: October 31, 2006Date of Patent: May 10, 2011Assignee: The United States of America as represented by the Secretary of the NavyInventors: Robert A. McGill, Eric J. Houser
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Patent number: 7935535Abstract: The invention provides a nanostructure material with metallic oxide including a product fabricated by the following steps: condensing silicon oxide or titanium oxide with a surfactant, obtaining a mesoporous silicon oxide or titanium oxide; mixing the mesoporous silicon oxide or titanium oxide with a metal or metallic compound and subjecting the mixture to a heterogeneous nucleation. According to another embodiment of the invention, the nanostructure material can also be fabricated by the following steps: subjecting silicon oxide or titanium oxide and a carbon black template to a calcination; mixing the results with a metal or metallic compound; and subjecting the mixture to a second calcinations. Further, in the invention, a method for detecting phosphorus-containing compounds employing the aforementioned nanostructure material is also provided.Type: GrantFiled: May 10, 2010Date of Patent: May 3, 2011Assignee: Industrial Technology Research InstituteInventors: Shaw-Yi Yen, Shou-Nan Li, Bo-Jui Chen, Hong-Ping Lin
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Publication number: 20110097810Abstract: This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.Type: ApplicationFiled: September 17, 2010Publication date: April 28, 2011Applicant: MONSANTO TECHNOLOGY LLCInventors: Donald D. Soleta, David R. Eaton, Peter E. Rogers, Eduardo A. Casanova, John Wagenknecht, Leonard Aynardi, David Z. Becher, Robert E. Byrd, James P. Coleman, Walter K. Gavlick, Eric A. Haupfear, Oliver Lerch, Carl Mumford, Alfredo Oba, Stephen D. Prosch, Bart Roose, Mark D. Scaia, Lowell R. Smith
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Publication number: 20110076735Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.Type: ApplicationFiled: June 15, 2010Publication date: March 31, 2011Inventors: Stevan B. Jovanovich, Iuliu I. Blaga
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Publication number: 20110065201Abstract: The invention provides a nanostructure material with metallic oxide including a product fabricated by the following steps: condensing silicon oxide or titanium oxide with a surfactant, obtaining a mesoporous silicon oxide or titanium oxide; mixing the mesoporous silicon oxide or titanium oxide with a metal or metallic compound and subjecting the mixture to a heterogeneous nucleation. According to another embodiment of the invention, the nanostructure material can also be fabricated by the following steps: subjecting silicon oxide or titanium oxide and a carbon black template to a calcination; mixing the results with a metal or metallic compound; and subjecting the mixture to a second calcinations. Further, in the invention, a method for detecting phosphorus-containing compounds employing the aforementioned nanostructure material is also provided.Type: ApplicationFiled: May 10, 2010Publication date: March 17, 2011Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Shaw-Yi Yen, Shou-Nan Li, Bo-Jui Chen, Hong-Ping Lin
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Patent number: 7906450Abstract: The invention provides an electrode comprising an electrically conductive material having a surface capable of producing surface enhanced Raman scattering of incident light from a complex adsorbed at the surface of the electrode, the complex including the electrically conductive material combined with a second material that is substantially reducible and not substantially oxidizable. The surface of the electrode can be microroughened. The invention also includes a method for making various embodiments of the electrode, and a method of generating electricity using the electrode. In accordance with a further aspect of the invention, a fuel cell is provided including the electrode of the invention.Type: GrantFiled: March 8, 2010Date of Patent: March 15, 2011Assignee: Fordham UniversityInventor: John J. McMahon
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Publication number: 20110059543Abstract: A method of detecting a cancer, such as ovarian cancer, in a test subject including (a) determining the amount of a lysophosphatidyl ethanolamine in a sample of a bodily fluid taken from the test subject, and (b) comparing the amount of the lysophosphatidyl ethanolamine in the sample of the bodily fluid taken from the test subject to a range of amounts of the lysophosphatidyl ethanolamine found in samples of the bodily fluid taken from a group of normal subjects of the same species as the test subject and lacking the cancer, such as ovarian cancer, whereby a change in the amount of the lysophosphatidyl ethanolamine in the sample of the bodily fluid from the test subject indicates the presence of the cancer, such as ovarian cancer.Type: ApplicationFiled: May 7, 2010Publication date: March 10, 2011Inventors: Lian Shan, Lorelei D. Davis, Rebecca Sutphen
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Publication number: 20110053283Abstract: Methods and systems described herein include beverage immersates and methods of their use. Systems include: at least one beverage immersate, wherein the at least one beverage immersate includes at least one sensor configured to detect at least one analyte in a fluid within a personal use beverage container; and at least one signal transmitter configured to transmit a signal responsive to the at least one beverage immersate. Methods include: detecting one or more analyte in fluid within a personal use beverage container with at least one sensor integral to at least one beverage immersate; and communicating data from the at least one beverage immersate to at least one device external to the beverage immersate.Type: ApplicationFiled: August 28, 2009Publication date: March 3, 2011Inventors: Leroy E. Hood, Edward K.Y. Jung, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, JR.
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Publication number: 20110027896Abstract: Applicants have produced a chromophore and a polymer that are highly sensitive to the presence of various agents, including organophosphates, pesticides, neurotoxins, metal ions, some explosives, and biological toxins. The detection is accomplished by detecting a change in the fluorescence characteristics of the chromophore or polymer when in the presence of the agent to be detected. The chromophore and polymer may be incorporated into sensors of various types, and they are adaptable for potential field use in areas where detection of these types of agents is desired.Type: ApplicationFiled: April 6, 2010Publication date: February 3, 2011Applicant: NDSU-Research FoundationInventors: Johnson Thomas, Philip Boudjouk
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Publication number: 20110008897Abstract: A system for warning of corrosion, chemical, or radiological substances. The system comprises painting a surface with a paint or coating that includes an indicator material and monitoring the surface for indications of the corrosion, chemical, or radiological substances.Type: ApplicationFiled: July 16, 2010Publication date: January 13, 2011Inventor: Joseph C. Farmer
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Publication number: 20100285602Abstract: The present invention relates to detectors for detecting fluorine-containing compounds and/or cyanide containing compounds, including hydrogen fluoride (HF) or HCN gas, hydrofluoric acid in solution, selected chemical warfare agents, selected industrial chemicals which may be hydrolysed to release HF or HCN gas, compounds containing a cyanide group, and compounds that can release HF or HCN. The detectors comprise i) an organometallic component containing at least one bis-substituted boryl group of the formula —B(RB)(RB+) wherein each RB and each RB? is independently selected from H, halogen, C1-6 alkyl, OR6, N(R6)(R7), SR6, C3-20 aryl or heteroaryl, and C3-20 cycloalkyl or heterocycloalkyl groups, each of which may be optionally substituted, ii) a Lewis base component, and iii) a solid matrix component.Type: ApplicationFiled: December 21, 2007Publication date: November 11, 2010Applicant: UNIVERSITY COLLEGE CARDIFF CONSULTANTS LTD.Inventors: Simon Aldridge, Ian A. Fallis
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Publication number: 20100279956Abstract: The present invention provides various biomarkers of fatty liver disease, including steatosis and steatohepatitis. The present invention also provides various methods of using the biomarkers, including methods for diagnosis of fatty liver disease, methods of determining predisposition to fatty liver disease, methods of monitoring progression/regression of fatty liver disease, methods of assessing efficacy of compositions for treating fatty liver disease, methods of screening compositions for activity in modulating biomarkers of fatty liver disease, methods of treating fatty liver disease, as well as other methods based on biomarkers of fatty liver disease.Type: ApplicationFiled: April 30, 2010Publication date: November 4, 2010Inventors: Bruce J. MC CREEDY, JR., Alvin Berger, YunFu Hu, Satish C. Kalhan
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Patent number: 7799571Abstract: This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.Type: GrantFiled: April 3, 2006Date of Patent: September 21, 2010Assignee: Monsanto Technology LLCInventors: Donald D. Soleta, David R. Eaton, Peter E. Rogers, Eduardo A. Casanova, John Wagenknecht, Leonard Aynardi, David Z. Becher, Robert E. Byrd, James P. Coleman, Walter K. Gavlick, Eric A. Haupfear, Oliver Lerch, Carl Mumford, Alfredo Oba, Stephen D. Prosch, Bart Roose, Mark D. Scaia, Lowell R. Smith
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Patent number: 7799568Abstract: A method for identifying a product includes providing a solid body (10) fabricated from at least a molecularly imprinted polymer having molecular sized cavities (12) adapted to selectively receive and bind molecules (50) having a specific taggant molecular structure (51), the molecular sized cavities (12) disposed on a portion of an exterior surface (11) of the body (10), and applying to the surface of the body a composition containing indicator molecules (50) having a taggant moiety (51) at one end and a marking function group (53) tethered to the taggant moiety (51) by a molecular chain the taggant moieties (51) engaging and binding to the molecular sized cavities (12) so as to mark the portion of the surface (11) of the body (10) with the indicator molecules (50) bound thereto, the marking functional groups (53) rendering the marked portion of the surface (11) perceptible with or without detection instrumentation.Type: GrantFiled: October 4, 2004Date of Patent: September 21, 2010Assignee: The Johns Hopkins UniversityInventors: Harry K. Charles, Jr., George M. Murray
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Publication number: 20100216118Abstract: A method that uses an L-?-dipalmitoleoyl-phosphatidylcholine (DPPC) surfactant based device that reacts with a substance in a known manner, to detect a substance of interest or to extract a substance of interest from a material is provided. The principles of the present invention are particularly useful in detecting/measuring a substance that is harmful to a human, and also to extracting NACL from saltwater.Type: ApplicationFiled: October 1, 2007Publication date: August 26, 2010Inventor: Mark L. Witten
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Patent number: 7759123Abstract: A method and apparatus for removing concentrated spots of collected particulates from an impact collection surface, and transferring those particulates into a container suitable for preparing a liquid sample. A jet of fluid can be utilized to remove and transfer the particulates. If a liquid jet is employed, care is taken to minimize the quantity of liquid to avoid unnecessarily diluting the sample. A mechanical scraper can alternatively be employed to remove and transfer the particulates into the container. The scraper can be rinsed with liquid or vibrated to remove the particulates. Alternatively, the portion of the surface containing a specific spot of particulates can be removed and placed into a container.Type: GrantFiled: March 21, 2006Date of Patent: July 20, 2010Assignee: MesoSystems Technology, Inc.Inventors: Charles J. Call, Patrick T. Call, Vanessa M. Kenning, Eric Hanczyc, Andrew Kamholz
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Patent number: 7749440Abstract: Methods and apparatus for chemical warfare agent detection training are provided. More particularly, methods and apparatus are provided to simulate the detection of low volatility chemical warfare agents by simulating the use of currently fielded U.S. Army detection kits without exposure to hazardous agents. A simulant is disposed in a sample heating assembly. The sample heating assembly is placed over a detection window of a detector, and the simulant is heated in order to make a simulated detection.Type: GrantFiled: January 12, 2006Date of Patent: July 6, 2010Assignee: The United States of America as represented by the Secretary of the ArmyInventor: James A. Genovese
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Publication number: 20100112545Abstract: Novel trans-1,2-diphenylethylene derivatives are synthesized which can be used to form nanoparticles-monomer-nanomolecule-receptor nanosensors. These trans-1,2-diphenyl-ethylene derivatives are soluble in both water and organic solvents, highly fluorescent and can be synthesized in high yields. The trans-1,2-diphenylethylene derivatives are bonded to a nanoparticle, a nanomolecule bonded to the derivative and a receptor bonded to the nanomolecule to form a nanosensor that can be used to detect chemical and biological agents.Type: ApplicationFiled: July 13, 2007Publication date: May 6, 2010Inventors: Subra Muralidharan, Chun Wang
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Patent number: 7696121Abstract: The invention provides an electrode comprising an electrically conductive material having a surface capable of producing surface enhanced Raman scattering of incident light from an adsorbate material adsorbed on the surface of the electrode. The adsorbate is substantially reducible and not substantially oxidizable. The surface of the electrode can be microroughened and include, for example, a plurality of adatoms or clusters of adatoms of a metallic material. The adatoms or clusters of adatoms form sites for photocatalysis of electroreduction when the electrode is irradiated with a light source. The invention also includes a method for making the electrode, and a method of generating electricity using the electrode. In accordance with a further aspect of the invention, a fuel cell is provided including the electrode of the invention.Type: GrantFiled: March 30, 2006Date of Patent: April 13, 2010Assignee: Fordham UniversityInventor: John J. McMahon
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Patent number: 7687424Abstract: The invention provides an electrode comprising an electrically conductive material having a surface capable of producing surface enhanced Raman scattering of incident light from a complex adsorbed at the surface of the electrode, the complex including the electrically conductive material combined with a second material that is substantially reducible and not substantially oxidizable. The surface of the electrode can be microroughened. The invention also includes a method for making various embodiments of the electrode, and a method of generating electricity using the electrode. In accordance with a further aspect of the invention, a fuel cell is provided including the electrode of the invention.Type: GrantFiled: June 28, 2007Date of Patent: March 30, 2010Assignee: Fordham UniversityInventor: John J. McMahon
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Publication number: 20100062536Abstract: In a method and apparatus for detecting toxic chemical hazardous materials and warfare agents in a gas, the gas is exposed to a substrate with a hydrogen terminated surface. The substrate may be made from a nonconductor material with available surface conductivity, or from a semiconductor material. The electrical resistance at the hydrogen terminated surface is measured to detect the presence of the hazardous materials and warfare agents. A method of producing such a substrate detector is also disclosed.Type: ApplicationFiled: November 12, 2007Publication date: March 11, 2010Inventors: Martin Eickhoff, Andreas Helwig, José Antonio Garrido, Gerhard Mueller
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Patent number: 7674627Abstract: The present invention provides methods and compositions for detecting, identifying and measuring the abundance of chemical nerve agents. Methods and compositions of the present invention are capable of providing selective detection of phosphorous based nerve agents, such as nerve agents that are esters of methyl phosphonic acid derivatives incorporating a moderately good leaving group at the phosphorus. Selectivity in the present invention is provided by a sensor composition having an alpha (?) effect nucleophile group that undergoes specific nucleophilic substitution and rearrangement reactions with phosphorus based nerve agents having a tetrahederal phosphorous bound to oxygen. The present invention includes embodiments employing a sensor composition further comprising a reporter group covalently linked to the alpha effect nucleophile group allowing rapid optical readout of nerve agent detection events, including direct visual readout and optical readout via spectroscopic analysis.Type: GrantFiled: December 15, 2005Date of Patent: March 9, 2010Assignee: University of WyomingInventors: Robert C. Corcoran, Aaron D. Strickland
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Publication number: 20100022008Abstract: The present invention provides methods and compositions for detecting, identifying and measuring the abundance of chemical nerve agents. Methods and compositions of the present invention are capable of providing selective detection of phosphorous based nerve agents, such as nerve agents that are esters of methyl phosphonic acid derivatives incorporating a moderately good leaving group at the phosphorus. Selectivity in the present invention is provided by a sensor composition having an alpha (?) effect nucleophile group that undergoes specific nucleophilic substitution and rearrangement reactions with phosphorus based nerve agents having a tetrahederal phosphorous bound to oxygen. The present invention includes embodiments employing a sensor composition further comprising a reporter group covalently linked to the alpha effect nucleophile group allowing rapid optical readout of nerve agent detection events, including direct visual readout and optical readout via spectroscopic analysis.Type: ApplicationFiled: December 15, 2005Publication date: January 28, 2010Inventors: Robert C. Corcoran, Aaron D. Strickland
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Publication number: 20100015655Abstract: The present disclosure relates to assays and kits for detecting and quantifying damage caused by a parasite in a subject and monitoring the progression of parasitic disease in a subject.Type: ApplicationFiled: July 17, 2008Publication date: January 21, 2010Applicant: Abbott LaboratoriesInventors: Maciej Adamczyk, Roy Jeffrey Brashear, Philip G. Mattingly
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Patent number: 7597855Abstract: The present invention relates to a porous adaptive membrane structure that has movable membranes. The structure can be made to change its gas, liquid or particulate permeability in response to surrounding environmental conditions. The application of this invention is includes protective apparel that is comfortable to wear wherein the level of protection provided is based on conditions in the environment. Hence, the protective apparel is highly breathable and comfortable in a non-hazardous environment but impermeable or only semipermeable in a hazardous environment.Type: GrantFiled: April 29, 2005Date of Patent: October 6, 2009Assignee: E. I. du Pont de Nemours and CompanyInventors: Joseph D. Trentacosta, Vivek Kapur
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Publication number: 20090142849Abstract: The present invention relates to the production and use of phosphate-specific marker ions labeled with one or more stable oxygen isotopes for analysis of phosphopeptides and other phosphorylated biological and synthetic molecules.Type: ApplicationFiled: October 3, 2008Publication date: June 4, 2009Applicant: University of ConnecticutInventor: Xudong Yao
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Publication number: 20090130655Abstract: The invention discloses a detection method using nanoaggregate-embedded beads and system thereof, which are characterized in that the nanoaggregate of Raman dye and metal nanoparticles is coated by an inorganic oxide to form a nanoaggregate-embedded bead, and which is then conjugated with a probe molecule to form a sensor bead. The Raman spectra of the product formed by binding of the sensor bead and an analyte in a sample is detected for determining whether the analyte exists in the sample. In embodiment, the pH of the solution of metal nanoparticles is controlled to keep at 10, and the concentration of the Raman dye is controlled to keep between 1×10?6M and 2×10?6M for reducing the size of the nanoaggregate.Type: ApplicationFiled: November 14, 2008Publication date: May 21, 2009Applicant: NATIONAL CHUNG CHENG UNIVERSITYInventors: Laikwan Chau, Tzyy-Schiuan Yang, Ping-Ji Huang, Tai-Tsung Lin
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Patent number: 7531359Abstract: The chemical compound: Each R1 is H or CH3. A device for detecting an analyte having: a substrate; a film on the substrate, a flow cell for delivering air containing the analyte to the film, and an apparatus for measuring the refractive index of the film. Each R2 is an alkyl group. Each X is O or S.Type: GrantFiled: March 1, 2006Date of Patent: May 12, 2009Assignee: The United States of America as Represented by the Secretary of the NavyInventors: Devanand Shenoy, Elias Feresenbet, Enrico Dalcanale, Susan Daly
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Publication number: 20090011515Abstract: This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.Type: ApplicationFiled: April 3, 2006Publication date: January 8, 2009Applicant: MONSANTO TECHNOLOGY LLCInventors: Donald D. Soleta, David R. Eaton, Peter E. Rogers, Eduardo A. Casanova, John Wagenknecht, Leonard Aynardi, David Z. Becher, Robert E. Byrd, James P. Coleman, Walter K. Gavlick, Eric A. Haupfear, Oliver Lerch, Carl Mumford, Alfredo Oba, Stephen D. Prosch, Bart Roose, Mark D. Scaia, Lowell R. Smith
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Patent number: 7470540Abstract: A method for preparing receptor-coated particles is described which comprises the following steps: a) providing a support body, b) conducting a liquid containing particles into or onto the support body, c) immobilizing the particles on at least one surface area of the support body, d) conducting a liquid which contains receptors or receptor building blocks for synthesizing polymeric receptors over the immobilized particles, e) coupling the receptors or receptor building blocks location—or/and time-specifically to the immobilized particles at in each case predetermined positions of the support body, f) repeating, where appropriate, the steps (d) and (e), until the desired receptors have been synthesized on the immobilized particles at the in each case predetermined positions of the support body.Type: GrantFiled: October 17, 2001Date of Patent: December 30, 2008Assignee: Febit AGInventors: Cord F. Stähler, Ramon Güimil, Matthias Scheffler, Peer F. Stähler, Anke Heidbrede
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Publication number: 20080280370Abstract: The present invention provides various methods and compositions which allow for determining the presence or amount of glyphosate, N-acetylglyphosate, N-acetyl AMPA or aminomethyl phosphoric acid (AMPA) and its various metabolites in a variety of test matrices. In one method, determining the presence or amount of N-acetylglyphosate and/or N-acetyl AMPA in a test sample comprises providing the test sample suspected of containing N-acetylglyphosate and/or N-acetyl AMPA; extracting the N-acetylglyphosate and/or N-acetyl AMPA from the test sample; and, detecting the N-acetylglyphosate and/or N-acetyl AMPA in the extract. In other methods, the presence or amount of at least one of glyphosate, N-acetylglyphosate, N-acetyl AMPA or aminomethyl phosphonic acid (AMPA) or a metabolite thereof in a test sample is determined.Type: ApplicationFiled: March 19, 2008Publication date: November 13, 2008Applicant: E.I. du PONT de NEMOURS and COMPANYInventors: Frederick Q. Bramble, JR., Anne M. Pentz
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Patent number: 7442340Abstract: A method and apparatus for sampling for the chemical warfare agent VX, where it is advantageous for the VX to be converted to its G-analog to facilitate aspirator induced movement of the sample through a sample line, to a sampling tube or to sample detection apparatus. A conversion tube assembly has a conversion tube member defining inlet and outlet openings and having a conversion filter therein, which is saturated with an A to G reagent for a chemical warfare agent of interest. The conversion filter assembly includes non-impregnated filter elements and the ends thereof and is retained in position intermediate to the ends of the conversion tube member by retainer elements, which may be tubes or rings. The conversion filter assembly is adapted to be received by a compression fitting or may be directly assembled to a sampling tube or sampling line.Type: GrantFiled: February 18, 2003Date of Patent: October 28, 2008Inventor: Robert Handly
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Publication number: 20080261321Abstract: The invention provides methods for detecting and isolating phosphomolecules using phosphoaffinity materials that comprise a hydrated metal oxide. In an embodiment, a method for detecting a phosphomolecule in a sample involves (a) contacting a sample with a phosphoaffinity material comprising a hydrated metal oxide, under conditions wherein a phosphomolecule is capable of binding to the phosphoaffinity material to form a phosphomolecule-phosphoaffinity material complex, and (b) detecting formation of a phosphomolecule-phosphoaffinity material complex, thereby detecting a phosphomolecule in the sample.Type: ApplicationFiled: July 6, 2005Publication date: October 23, 2008Applicant: PERKINELMER LAS, INC.Inventors: Wayne F. Patton, Alvydas Mikulskis, Eva Golenko