Of Crystal Or Crystalline Material Patents (Class 436/4)
-
Patent number: 7816114Abstract: Methods of using monoclinic crystals of human beta-secretase (BACE) having unit cell dimensions of a, b, and c, wherein a is about 81±20 ? to about 101 ?, b is 103±20 ?, c is 100±20 ?, and ?=?=90°, and ? is 105°±10° for crystals of symmetry P21 and a=73.1, b=105.1, c=50.5 ? and ? is 94.8° for crystals of C2 symmetry in drug screening assays comprising selecting a potential modifier by adding the potential modifiers to an aqueous mixture of the crystal and detecting a measure of binding, such that the potential modifier that binds is selected as a potential drug.Type: GrantFiled: December 6, 2008Date of Patent: October 19, 2010Assignee: Elan Pharmaceuticals, Inc.Inventors: Timothy Benson, D. Danielle Woods, Donald Prince
-
Patent number: 7799547Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.Type: GrantFiled: January 11, 2006Date of Patent: September 21, 2010Assignee: Affinium Pharmaceuticals, Inc.Inventors: Donald E. Awrey, Teresa Clarke McGrath, Vladimir Romanov
-
Patent number: 7776573Abstract: The present invention concerns determination of the crystal structure of the macrophage specific receptor, CRIg (earlier referred to as STIgMA), and its complex with the C3b and C3c subunits of complement C3 (C3b:CRIg and C3c:CRIg complexes). The invention further concerns the use of the crystal structure of CRIg or the C3b:CRIg complex to screen for and identify molecules structurally and/or functionally related to CRIg, including CRIg agonists and antagonists.Type: GrantFiled: May 30, 2007Date of Patent: August 17, 2010Assignee: Genentech, Inc.Inventors: Philip Hass, Jianping Yin, Kenneth Katschke, Micah Steffek, Menno Van Lookeren Campagne, Christian Wiesmann
-
Patent number: 7769575Abstract: The crystal structures of catalytic domain of HPTPbeta, both ligand-bound and ligand-free are described. These structures are useful in computer aided drug design for identifying compounds that bind or activate HPTPbeta and thereby modulate angiogenesis mediated disorders or diseases.Type: GrantFiled: March 23, 2009Date of Patent: August 3, 2010Assignee: Warner Chilcott, LLCInventors: Artem Gennady Evdokimov, Matthew Eugene Pokross
-
Patent number: 7754458Abstract: The disclosure provides a crystal structure of a complex of the HGF ?-chain with am extracellular fragment of the Met receptor, as well as use of the crystal structure in the design, identification, and selection of ligands that modulate the Met Receptor and the interaction of HGF with the Met receptor.Type: GrantFiled: January 17, 2008Date of Patent: July 13, 2010Assignee: Genentech, Inc.Inventors: Christian Wiesmann, Jennifer Stamos
-
Patent number: 7745220Abstract: The present invention provides devices and methods for detection of analytes based on measuring the anchoring strength of liquid crystals having distorted geometries. Methods for detecting an analyte in a sample include the steps of: (a) capturing an analyte on a substrate surface wherein the substrate surface defines an easy axis when in contact with a liquid crystal. Substrate surface and liquid crystal are brought into contact and an analyte-dependent departure in the orientation of the liquid crystal from the easy axis of the substrate surface is measured. This departure indicates the presence of the analyte in the sample.Type: GrantFiled: October 3, 2006Date of Patent: June 29, 2010Assignee: Wisconsin Alumni Research FoundationInventors: Nicholas L. Abbott, Brian H. Clare
-
Patent number: 7727953Abstract: Ac-Sar-Gly-Val-D-allo-Ile-Thr-Nva-Ile-Arg-ProNHCH2CH3 Crystalline Form 1, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.Type: GrantFiled: December 22, 2006Date of Patent: June 1, 2010Assignee: Abbott Laboratories Inc.Inventors: John C. Tolle, Ahmad Y. Sheikh
-
Patent number: 7724319Abstract: A method of forming a liquid crystal device, includes: contacting an aqueous solution comprising a surfactant and a receptor molecule with a top surface of a liquid crystal. The liquid crystal is in a holding compartment of a substrate, and the receptor molecule is adsorbed on the top surface of the liquid crystal forming an interface between the liquid crystal and the aqueous solution. The receptor molecule is different than the surfactant. A method of detecting a compound in a flowing stream includes passing an aqueous solution over a top surface of a liquid crystal in a holding compartment of a substrate. The method also includes determining whether a change in the orientation of the liquid crystal occurs as the aqueous solution is passed over the top surface of the liquid crystal. A change in the orientation of the liquid crystal indicates the presence of the compound in the flowing stream.Type: GrantFiled: November 26, 2008Date of Patent: May 25, 2010Assignee: Wisconsin Alumni Research FoundationInventors: Nicholas L. Abbott, Jeffrey M. Brake
-
Publication number: 20100093096Abstract: The present invention relates to the field of detection of components in gas phase, and in particular to detection of nitric oxide exhaled as a component of breath, using a liquid crystal assay format and a device utilizing liquid crystals as part of a reporting system.Type: ApplicationFiled: September 15, 2009Publication date: April 15, 2010Applicant: PLATYPUS TECHNOLOGIES, LLCInventors: Bharat Acharya, Avijit Sen, Nicholas Abbott, Kurt Kupcho
-
Patent number: 7691969Abstract: An isolated GRP94 ligand binding domain polypeptide, a three-dimensional crystal structure of the same, and methods of using the same to design modulators of Hsp90 proteins.Type: GrantFiled: September 30, 2002Date of Patent: April 6, 2010Assignee: Duke UniversityInventors: Daniel T. Gewirth, Christopher V. Nicchitta
-
Patent number: 7693698Abstract: This disclosure relates to LINGO-1 polypeptides, LINGO-1 polypeptide/ligand complexes, crystals of LINGO-1 polypeptides, crystals of LINGO-1 polypeptide/ligand complexes, and related methods and software systems.Type: GrantFiled: February 1, 2007Date of Patent: April 6, 2010Assignee: Wyeth LLCInventors: Lidia Mosyak, Brian Dwyer, Mark Johnson, Xiaotian Zhong, Eleonora Presman, James M. Wilhelm, Mark Stahl, William Stuart Somers
-
Publication number: 20100081123Abstract: The present invention provides devices and methods for detection of analytes based on measuring the anchoring strength of liquid crystals having distorted geometries. Methods for detecting an analyte in a sample include the steps of: (a) capturing an analyte on a substrate surface wherein the substrate surface defines an easy axis when in contact with a liquid crystal. Substrate surface and liquid crystal are brought into contact and an analyte-dependent departure in the orientation of the liquid crystal from the easy axis of the substrate surface is measured. This departure indicates the presence of the analyte in the sample.Type: ApplicationFiled: October 3, 2006Publication date: April 1, 2010Applicant: Wisconsin Alumi Research FoundationInventors: Nicholas L. Abbott, Brian H. Clare
-
Patent number: 7655446Abstract: The present invention relates to human Rho-kinase I (ROCK I), ROCK I binding pockets, ROCK I-like binding pockets. More particularly, the present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ROCK I protein or ROCK I protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising ROCK I kinase domain and ROCK I kinase domain complexed with an inhibitor of that domain. The invention also relates to methods of identifying inhibitors of the ROCK I kinase domain.Type: GrantFiled: June 28, 2006Date of Patent: February 2, 2010Assignee: Vertex Pharmaceuticals IncorporatedInventors: Marc Jacobs, Koto Hayakawa, Mark Fleming, John Doran, Craig Marhefka
-
Patent number: 7615363Abstract: This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.Type: GrantFiled: August 24, 2006Date of Patent: November 10, 2009Assignee: WyethInventors: Lidia Mosyak, Thomas Saltmarsh Rush, III, Xiaotian Zhong, Thomas E. McDonagh, Katy E. Georgiadis, Phaik-Eng Sum, Edward R. LaVallie, Lisa A. Collins-Racie, Christopher John Corcoran, Ravindra Kumar, Tracy Hebert, Stephane Hubert Olland, Stewart Andrews Mackie
-
Patent number: 7601528Abstract: An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three dimensional x-ray crystal structure has been solved to 3.2 ? resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of human beta secretase activity.Type: GrantFiled: January 25, 2005Date of Patent: October 13, 2009Assignee: Elan Pharmaceuticals, Inc.Inventors: Timothy E. Benson, Jim D. Durbin, D. Bryan Prince
-
Patent number: 7569391Abstract: The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of ?-secretase (BACE) polypeptide. The present application also relates to crystalline forms of uncomplexed BACE and the three-dimensional structure of BACE, as determined from the crystals. In addition, the present application relates to the use of crystalline forms of BACE to identify ligands, preferably inhibitors (antagonists), which bind to, and preferably inhibit the enzymatic activity of, BACE. Furthermore, the present application relates to nucleic acid sequences encoding human BACE polypeptide, and methods for making BACE in greater quantity than prior methods, resulting in more effective crystallization.Type: GrantFiled: December 6, 2006Date of Patent: August 4, 2009Assignee: Schering CorporationInventors: Brian M. Beyer, Bruce A. Malcolm, Corey O. Strickland, Wenyan Wang, Eileen Wilson
-
Patent number: 7563610Abstract: Provided are crystals relating to Farsenyl Pvrophosphate Synthase (IspA) from E. coli and its various uses.Type: GrantFiled: August 28, 2003Date of Patent: July 21, 2009Assignee: Takeda San Diego, Inc.Inventors: Alexei Brooun, Douglas R. Dougan, David Hosfield, Yanming Zhang
-
Patent number: 7556950Abstract: Provided are crystals relating to human phosphodiesterase 4-D3 (PDE4-D3), methods for forming crystals comprising PDE4-D3 and crystals comprising PDE4-D3 co-crystallized with a ligand molecule, and methods of using crystals comprising PDE4-D3.Type: GrantFiled: April 29, 2004Date of Patent: July 7, 2009Assignee: Takeda San Diego, Inc.Inventors: Alexei Brooun, Ellen Chien, Douglas R. Dougan, Michelle L. Kraus, Clifford D. Mol, Gyorgy Snell
-
Patent number: 7524668Abstract: The present invention provides a crystal of human beta-secretase (BACE) having monoclinic space group symmetry C2, in a representative example, comprising a unit cell having dimensions of a, b, and c, wherein a is about 53 ? to about 103 ?, b is about 85 ? to about 125 ?, c is about 40 ? to about 60 ?, and ?=?=90°, and ? is about 85° to about 105°, and in a preferred example, comprising unit cell dimensions as follows: a is 73.1 ?, b is 105.1 ?, c is 50.5 ?, and ?=?=90°, and ? is 94.8, wherein the Matthews coefficient of said crystal is 2.1 ?/Da with 42% solvent, and wherein said crystal diffracts to 1.7 ? resolution.Type: GrantFiled: May 10, 2002Date of Patent: April 28, 2009Assignee: Elan Pharmaceuticals, Inc.Inventors: Timothy E. Benson, D. Danielle Woods, Donald Bryan Prince
-
Patent number: 7521254Abstract: The present invention provides methods which allows for the determination of concentration or solubility in a multi-component system using Raman spectroscopy. The present invention circumvents the necessity of constructing a calibration curve in order to analytically determine the concentration/solubility of a solute in a homogeneous liquid or a homogeneous solid. Methods of determining the saturation concentration of a solute in a polymer matrix or a polymer matrix film are also provided.Type: GrantFiled: April 11, 2005Date of Patent: April 21, 2009Assignee: Transform Pharmaceuticals, Inc.Inventors: Wendy Pryce-Lewis, Evie Sun, Kentaro Shimizu
-
Patent number: 7521538Abstract: The present invention relates to a crystal of a ternary complex composed of the protein 14-3-3, a ligand thereof and a fragment of Plasma Membrane ATPase (PMA) comprising the coordinates of table 4 or coordinates which differ from the coordinates of table 4 by a root mean square deviation of the C-alpha atoms of less than 3 Angstrom, wherein (a) protein 14-3-3 consists of the amino acid sequence of SEQ ID NO: 1 or of the sequence of a species homolog; (b) the ligand is Fusicocdin; (c) PMA is a C-terminal peptide of up to 15 amino acid residues in length; comprising the amino acid sequence of SEQ ID NO: 2 or comprising the sequence of a species homolog. Moreover, the invention also relates to methods for obtaining crystals of 14-3-3 in ternary complex and to methods relating to the determination of said 14-3-3 crystal coordinates.Type: GrantFiled: February 26, 2004Date of Patent: April 21, 2009Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Alfred Wittinghofer, Martin Würtele, Claudia Oecking, Christian Jelich-Ottmann
-
Patent number: 7507552Abstract: Provided are crystals relating to histone deacetylase 2 (HDAC-2) and its various uses.Type: GrantFiled: April 16, 2004Date of Patent: March 24, 2009Assignee: Takeda San Diego, Inc.Inventors: Ciaran N. Cronin, Mark T. Hilgers, Mark W. Knuth, Marc E. Navre, Bi Ching Sang, Robert J. Skene, Leslie W. Tari, Keith P. Wilson, Darbi Witmer, Hua Zou
-
Patent number: 7507568Abstract: The crystal structures of catalytic domain of HPTPbeta, both ligand-bound and ligan-free are described. These structures are useful in computer aided drug design for identifying compounds that bind or activate HPTPbeta and thereby modulate angiogenesis mediated disorders or diseases.Type: GrantFiled: August 4, 2003Date of Patent: March 24, 2009Assignee: The Proctor & Gamble CompanyInventors: Artem Gennady Evdokimov, Matthew Eugene Pokross
-
Patent number: 7504486Abstract: The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution for determining the three-dimensional structure of ribosomes and ribosomal subunits, for identifying ligand binding sites on ribosomes and ribosomal subunits, and for molecular modeling of ligands which interact with ribosomes and ribosomal subunits. The present invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties. Thus, the methods of the present invention may be used to produce ligands which are designed to kill or inhibit any specific target organism(s).Type: GrantFiled: March 17, 2003Date of Patent: March 17, 2009Assignee: Yale UniversityInventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen
-
Patent number: 7498419Abstract: The present invention provides crystalline forms of domain III of the West Nile Virus (“WNV”) envelope protein in complex with a Fab fragment of a neutralizing antibody, methods of obtaining such crystals and high-resolution structures and atomic structure coordinates. The crystals of the invention and the atomic structural information are useful for solving crystal and solution structures of related and unrelated proteins, and for screening for, identifying or designing compounds or antibodies that bind to, modulate a biological activity of, or neutralize infection mediated by flaviviral envelope proteins.Type: GrantFiled: October 14, 2005Date of Patent: March 3, 2009Assignee: Washington UniversityInventors: Daved H. Fremont, Grant Nybakken, Michael Diamond
-
Patent number: 7498157Abstract: A crystal of a dipeptidyl peptidase IV; a three-dimensional structural coordinate of the dipeptidyl peptidase IV; a method for obtaining a three-dimensional coordinate of a homolog protein of the dipeptidyl peptidase IV; a method for obtaining a three-dimensional structural coordinate of a crystal of a complex of the dipeptidyl peptidase IV and an effector of the dipeptidyl peptidase IV; a method for identifying pharmacophore of the effector of the dipeptidyl peptidase IV; a method for designing, identifying, evaluating or searching; the effector; and a program and a medium therefor for use of the three-dimensional structural coordinate.Type: GrantFiled: July 28, 2003Date of Patent: March 3, 2009Assignee: Mitsubishi Tanabe Pharma CorporationInventors: Hajime Hiramatsu, Kiyoshi Kyono, Hideaki Shima, Shigeru Sugiyama
-
Patent number: 7499847Abstract: The present invention relates to crystalline vascular adhesion protein-1 (VAP-1) and in particular to methods for the use of structural information of crystalline human VAP-1 for ligand and/or inhibitor identification, design and production, as well as screening assays for detection of same. The invention further relates to inhibitors identified by the assays according to the present invention.Type: GrantFiled: May 25, 2004Date of Patent: March 3, 2009Assignee: Biotie Therapies CorporationInventors: Tiina Salminen, Tomi Airenne, Mark Johnson, Heidi Kidron, Yvonne Nymalm-Rejström, Annu Söderholm, David Smith, Marjo Pihlavisto, Lenita Viitanen, Olli Pentikäinen, Tommi Nyrönen
-
Patent number: 7494795Abstract: The invention relates to FMS-like tyrosine kinase (FLT3), FLT3 binding pockets or FLT3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to FMS-like tyrosine kinase protein, complexes of FMS-like tyrosine kinase protein, homologues thereof, or FLT-3-like protein or protein complexes. The invention also relates to crystallizable compositions and crystals comprising an FMS-like tyrosine kinase cytoplasmic domain or homologues thereof. The invention also relates to methods of identifying inhibitors of the cytoplasmic domain of FMS-like tyrosine kinase protein.Type: GrantFiled: September 15, 2004Date of Patent: February 24, 2009Inventors: James Paul Griffith, James Roger Black, Carlos H. Faerman, Lovorka Lora Swenson, Michael Andrew Wynn, Fan Lu, Judith A. Lippke, Kumkum Saxena
-
Patent number: 7491523Abstract: The present invention relates to crystallized forms of a voltage dependent calcium channel ? subunit functional core, methods of producing and methods of utilizing the same.Type: GrantFiled: May 11, 2005Date of Patent: February 17, 2009Inventor: Joel A. Hirsch
-
Patent number: 7459124Abstract: A method of forming a liquid crystal device, includes: contacting an aqueous solution comprising a surfactant and a receptor molecule with a top surface of a liquid crystal. The liquid crystal is in a holding compartment of a substrate, and the receptor molecule is adsorbed on the top surface of the liquid crystal forming an interface between the liquid crystal and the aqueous solution. The receptor molecule is different than the surfactant. A method of detecting a compound in a flowing stream includes passing an aqueous solution over a top surface of a liquid crystal in a holding compartment of a substrate. The method also includes determining whether a change in the orientation of the liquid crystal occurs as the aqueous solution is passed over the top surface of the liquid crystal. A change in the orientation of the liquid crystal indicates the presence of the compound in the flowing stream.Type: GrantFiled: September 19, 2006Date of Patent: December 2, 2008Assignee: Wisconsin Alumni Research FoundationInventors: Nicholas L. Abbott, Jeffrey M. Brake
-
Patent number: 7459296Abstract: This invention provides fragments of HCV NS3 helicase, and crystalline compositions thereof, based on subdomains of HCV helicase protein. The protein fragments are stable, soluble, and structurally sound. They can be expressed at high levels in conventional expressions systems, such as E. coli, to permit efficient, large-scale production for NMR-based screening applications and production of [2H,13C,15N]- and [13C,15N]-labeled polypeptides for structural NMR studies. Helicase fragments of the present invention are useful in the most advanced NMR techniques available, e.g., NMR-based drug discovery techniques such as SAR-by-NMR, in biological assays to discover inhibitors of HCV NS3 helicase, and to evaluate the mechanism of action and substrates for HCV NS3 helicase. Crystals of the present invention are useful for structure-based drug design studies using x-ray crystallographic techniques.Type: GrantFiled: April 3, 2001Date of Patent: December 2, 2008Assignee: Schering CorporationInventors: Patricia C. Weber, Paul Reichert, Vincent S. Madison, Daniel F. Wyss, Nanhua Yao, Dingjiang Liu, Jennifer J. Gesell
-
Patent number: 7445923Abstract: This invention relates to the crystal structure of a plant peptide deformylase polypeptide and methods of using the structure to design compounds that modulate the activity of the polypeptide.Type: GrantFiled: October 3, 2006Date of Patent: November 4, 2008Assignee: University of Kentucky Research FoundationInventors: Robert L. Houtz, David W. Rodgers, Lynette M. A. Dirk, Mark A. Williams
-
Patent number: 7442537Abstract: The x-ray crystal structure of BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of BACE activity.Type: GrantFiled: May 9, 2003Date of Patent: October 28, 2008Assignee: Elan Pharmaceuticals, Inc.Inventors: Timothy E. Benson, Daisy Danielle Woods, Donald Bryan Prince
-
Patent number: 7444273Abstract: Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses.Type: GrantFiled: June 20, 2003Date of Patent: October 28, 2008Assignee: Takeda San Diego, Inc.Inventors: Ciaran N. Cronin, Mark W. Knuth, Duncan E. McRee, Jacek Nowakowski, Nikola P. Pavletich, Devon A. Thompson, Robert A. Wijnands
-
Patent number: 7433788Abstract: Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising a precipitant to form a mixture; and crystallizing the mixture, optionally also recrystallizing and isolating the crystalline IGF-1. In addition, a method for identifying IGF-1 indirect agonists is provided using a detergent as a standard for the level of inhibition of binding of IGFBP-1 or IGFBP-3 to IGF-1 and/or using the coordinates of the binding pockets of IGF-1 to which a candidate indirect agonist binds for structure-based drug design.Type: GrantFiled: June 20, 2006Date of Patent: October 7, 2008Assignee: Genentech, Inc.Inventors: Michelle Schaffer, Mark Ultsch, Felix Vajdos
-
Patent number: 7422885Abstract: The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human Aurora 2 kinase. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human Aurora 2 kinase in structure assisted drug design to identify compounds that can modulate the enzymatic activity of human Aurora 2 kinase.Type: GrantFiled: September 17, 2004Date of Patent: September 9, 2008Assignee: Schering CorporationInventors: Thierry O. Fischmann, Vincent S. Madison, Alan William Hruza, Paul Reichert, Lata Ramanathan, David Paul Sanden, Wolfgang Seghezzi
-
Patent number: 7384773Abstract: The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of human BACE activity.Type: GrantFiled: May 10, 2002Date of Patent: June 10, 2008Assignee: Pfizer IncInventors: Timothy E. Benson, Jim D. Durbin, Thomas L. Emmons, Alfredo G. Tomasselli
-
Patent number: 7368269Abstract: Provided are crystals relating to human mitogen-activated protein kinase kinase2 (MAPKK2), also known as MAPK/ERK Kinase2 (MEK2) and its various uses.Type: GrantFiled: March 7, 2005Date of Patent: May 6, 2008Assignee: Takeda San Diego, Inc.Inventors: Ciaran N. Cronin, Douglas R. Dougan, Mark W. Knuth, Michelle L. Kraus, Kheng Lim, Clifford D. Mol, Gyorgy Snell, Hua Zou
-
Patent number: 7368288Abstract: The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as “crystallization pattern”) containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. It has been shown that changes in the crystallization patterns of a number of amino-acids can be used as a “signature” of a protein added. It was also found that both the character of changer in the crystallization patter and the fact of such changes can be used as recognition elements in analysis of protein molecules.Type: GrantFiled: April 5, 2006Date of Patent: May 6, 2008Assignee: George Mason Intellectual Properties, Inc.Inventors: Victor Morozov, Charles L. Bailey, Nikolai N. Vsevolodov, Adam Elliott
-
Patent number: 7361492Abstract: The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.Type: GrantFiled: November 1, 2004Date of Patent: April 22, 2008Assignee: Vertex Pharmaceuticals IncorporatedInventors: Graham Cheetham, Ronald Knegtel, Lovorka Swenson, Joyce T. Coll, Suzanne Renwick, Peter Weber
-
Publication number: 20080075138Abstract: Provided is a method of identifying crystal defect regions of monocrystalline silicon using metal contamination and heat treatment. In the method, a sample in the shape of a silicon wafer or a slice of monocrystalline silicon ingot is prepared. At least one side of the sample is contaminated with metal at a contamination concentration of about 1×1014 to 5×1016 atoms/cm2. The contaminated sample is heat-treated. The contaminated side or the opposite side of the heat-treated sample is observed to identify a crystal defect region. The crystal defect region can be analyzed accurately, easily and quickly without the use of an additional check device, without depending on the concentration of oxygen in the monocrystalline silicon.Type: ApplicationFiled: September 20, 2007Publication date: March 27, 2008Inventors: Sang-Wook WEE, Seung-Wook LEE, Ki-Man BAE, Kwang-Salk KIM
-
Patent number: 7326552Abstract: Provided are crystals relating to human Ephrin Receptor A2 and its various uses.Type: GrantFiled: June 20, 2003Date of Patent: February 5, 2008Assignee: Takeda San Diego, Inc.Inventors: Ciaran N. Cronin, Jacek Nowakowski, Nikola P. Pavletich, Devon A. Thompson
-
Patent number: 7312082Abstract: The present invention relates to a crystal structure of G-quadruplexes and its use. The invention provides a crystal of an intramolecular G-quadruplex structure having a hexagonal space group P6, and unit cell dimensions a=b=56.7 and c=42.1; ?=?=90°, ?=120° and a crystal of G-quadruplex having the three dimensional atomic coordinates of Table 1 or Table 2. These structures may be used in a computer-based method for the analysis of the interaction of a molecular structure with a G-quadruplex.Type: GrantFiled: April 2, 2003Date of Patent: December 25, 2007Assignee: Cancer Research Technology LimitedInventors: Stephen Neidle, Gary N. Parkinson
-
Patent number: 7300750Abstract: The present invention provides an assay device for detection of an analyte which is a member of a specific binding partner in a sample, the assay device comprising a sample application zone, a preabsorbing zone and a specific binding zone. The device can provide a HSV-2 specific assay by preabsorbing HSV-1 antibodies in the preabsorbing zone.Type: GrantFiled: December 11, 2000Date of Patent: November 27, 2007Assignee: Oran DX LimitedInventors: David Smart, Patrick Considine, Marie Eagleton
-
Patent number: 7285408Abstract: The present invention discloses purified polypeptides that comprise an active human ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human ADAM33 catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human ADAM33. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human ADAM33 in structure based drug design to identify compounds that can modulate the enzymatic activity of human ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the human ADAMS33 catalytic domain.Type: GrantFiled: December 19, 2003Date of Patent: October 23, 2007Assignee: Schering CorporationInventors: Peter Orth, Paul Reichert, Vincent S. Madison, Wenyan Wang, Jun Zou
-
Patent number: 7276477Abstract: The present invention relates to crystalline etanercept and to methods of making crystalline etanercept; to pharmaceutical compositions comprising crystalline etanercept; and to therapeutic uses of such compositions.Type: GrantFiled: July 29, 2004Date of Patent: October 2, 2007Assignee: Amgen Inc.Inventors: Timothy D. Osslund, Christi L. Clogston, Shon Lee Crampton, Randal B. Bass
-
Patent number: 7270987Abstract: Provided are crystals and structure coordinates relating to FMS-like tyrosine kinase 3 and its various uses.Type: GrantFiled: November 30, 2004Date of Patent: September 18, 2007Assignee: Takeda San Diego, Inc.Inventors: Ellen Chien, Ciaran N. Cronin, Douglas R. Dougan, Kheng Lim, Clifford D. Mol, Bi Ching Sang, Garret Textor
-
Patent number: 7267957Abstract: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.Type: GrantFiled: April 26, 2002Date of Patent: September 11, 2007Assignee: Kent State UniversityInventors: Christopher J Woolverton, Gary D Niehaus, Kathleen J Doane, Oleg D Lavrentovich, Steven P Schmidt, Steven A Signs
-
Patent number: 7148066Abstract: Systems and methods providing for the introduction of a dye, particularly a xanthene dye, and more particularly a rhodamine dye, to liquid anhydrous ammonia to discourage theft of the anhydrous ammonia and provide for leak detection in storage vessels. The dye will stain objects which come into contact with the liquid anhydrous ammonia allowing for the detection of such contact. Generally, the staining will be visible to the naked eye, but may also fluoresce when exposed to a particular light source such as ultra violet (UV) light.Type: GrantFiled: August 2, 2004Date of Patent: December 12, 2006Assignee: GloTell Products, Inc.Inventors: Tim Bickett, Frank Eiter
-
Patent number: 7135143Abstract: A device for detecting a compound in a sample includes a substrate and a self-assembled monolayer. The substrate includes a support with a metallized top surface, and the self-assembled monolayer includes an alkanethiol attached to the metallized top surface of the substrate and having a functional group that reversibly or irreversibly interacts with the compound. A liquid crystal is disposed on the self-assembled monolayer opposite the side of the self-assembled monolayer attached to the metallized top surface of the substrate. The liquid crystal includes a moiety that interacts with the functional group of the alkanethiol. When the compound is present in a sample that that contacts the self-assembled monolayer, the orientation of the liquid crystal is altered.Type: GrantFiled: August 16, 2001Date of Patent: November 14, 2006Assignee: Wisconsin Alumni Research FoundationInventors: Nicholas L. Abbott, Rahul R. Shah