Abstract: A fluid dispensing system and method includes a pump to aspirate and expel sample fluid, a fluid dispensing tip, and a metering station. The fluid dispensing tip includes a working fluid and an air gap where the air gap separates the working fluid from the sample fluid. The metering station receives a drop of sample fluid that is at least twice as large as the predetermined volume to ultimately be dispensed. The fluid dispensing tip then withdraws the predetermined volume of fluid from the sample fluid. Precise volumes are ascertained by prior knowledge of the geometry of the fluid dispensing tip and by using an imaging device to monitor an interface of either the sample fluid or working fluid with the air gap within the fluid dispensing tip. The system and method are capable of accurately dispensing very small volumes of sample fluid on the order of 10 picoliters. In addition, the system and method do not require large volumes of sample fluid to prime a pump mechanism.

Abstract: The present invention provides a liquid handling system capable of automated dispensing and reformatting operations by virtue of a quick-release cannula array mounting system that permits cannula arrays to be changed automatically by the system or manually by a user. Automated changing of the cannula array is carried out by relative movement of the dispensing head and the sample support surface to deliver the attached cannula array to a storage location, releasing the array from the dispensing head, and attaching a new cannula array. Relative movement between the dispensing head and sample support surface in at least two dimensions increases flexibility of the system and makes self-loading of the cannula array practical. The system provides advantages in time and accuracy of cannula array changeover procedures. The automated cannula array changeover capability permits automated wellplate reformatting procedures, which can be performed quickly and accurately.

Abstract: An automated workstation capable of continuous, non-stop processing of specimens includes an environmentally controlled storage area that holds multiple cassettes containing specimen plates. A robotic arm for processing the specimens, e.g., by grasping the plates, moving them from the cassettes to other apparatus contained within the workstation, and placing the plates back in the cassettes. An interlock mechanism prevents the operator and robotic arm from simultaneously accessing a cassette. Novel robotic arms, robotic arm positioning mechanisms, plate handling mechanisms, effector tip/plate washing mechanisms, thin-walled pipetters, back-flushing mechanisms and fluid level detection mechanisms, as well as methods for operating the same, facilitate continuous operation of the workstation along with compactness, high throughput and high accuracy of operation. Narrow, thin-walled capillary-like pipetters serve as both means for acquiring and processing small quantity specimens with high precision.

Abstract: A sample handler includes a plurality of sealable metering tips, each of the tips, when sealed, containing a fluid volume of a test fluid and in which each of the sealed metering tips acts as an auxiliary sample supply container for use with at least one chemistry system of a clinical analyzer.

Abstract: A clinical analyzer for determining the presence or amount of an analyte in a sample includes at least one reagent supply and at least one reaction containment device for containing a volume of sample and a volume of said at least one reagent from said at least one reagent supply. A wash-free delivery system introduces reagent into at least one reaction containment device without requiring washing of delivery components.

Abstract: A self-adjusting, free-flowing pneumatic nebulizer interface is described for coupling fluid phase separation apparatus such as capillary electrophoresis apparatus or fluid-phase analyte delivery apparatus such as flow-injection analysis apparatus to gas phase, post-separation detection apparatus such as mass spectrometers, chemiluminescence detectors, or other similar gas phase detection apparatus. The interface combines the analytes with only the needed amount of sheath fluid to produce a combined flow whose magnitude automatically matches the self-aspiration rate of the pneumatic nebulizer interface, and which is combined with a gas flow to produce an aerosol. The resulting aerosol can then be either deposited directly on a surface, forwarded directly to a detection system or forwarded first to a conversion apparatus such as an oxidizer and the oxidized sample components are then forwarded to a detector.

Abstract: The present invention provides an improved apparatus and method for loading tips onto a pipettor. A means for applying removal force on the pipette tip box is provided so as to ensure that the box is dislodged from the pipette tips after the pipette tips have been forced onto the dispense head mandrels. In the preferred embodiment, the shuck arms are modified to incorporate springs such that when the engagement force is removed from the pipette tip box, the shuck arms are forced by the springs against the pipette tip box thereby displacing the pipette tip box from the pipette tips.

Abstract: The present invention relates to a method and apparatus for controlling magnetic particles by a sample distributor and is intended to process a sample liquid with high precision, sensitivity and reliability by arresting magnetic particles to separate them from the liquid and by suspending the magnetic particles in a liquid to mix the magnetic particles with the liquid again. The pipette portion of this invention has a front end portion, a reservoir portion, a liquid passage connecting the front end portion and the reservoir portion, and a separation region in the liquid passage that is subjected to a magnetic field. The pipette portion of this construction draws in or discharges a liquid for processing.

Abstract: The liquid sample take-up device comprises two layers of concentric tubing. An outer tube has a fluid take-up end for selective immersion in a liquid to be sampled, and a liquid connection spaced from the fluid take-up end adapted to receive a chemical reagent under pressure, creating a reagent flow toward the take-up end. An inner tube is disposed within the outer tube and has an open end adjacent to the outer tube take-up end. The inner tube is adapted to fluid connect to a negative pressure source, higher than the reagent pressure, to create a fluid flow within the inner tube in a direction away from the open end, whereby sampled liquid and reagent are mixed adjacent the inner tube open end and within the outer tube take-up end. When the outer tube take-up end is not immersed in a liquid to be sampled, air is drawn into the outer tube take-up end and into the inner tube open end, creating a series of air bubbles, each bubble separated by a volume of reagent.

Abstract: In one embodiment, a particle-retrieval device in accordance with the present teachings includes a receiver tube, vacuum-flow providing means and particle-disengaging means. The receiver tube is in fluid communication with the vacuum-flow providing means such that when flow is introduced into the vacuum-flow providing means, a suction or vacuum flow is developed at an end of the receiver tube. The suction causes a particle to adhere to the end of the receiver. A particle is disengaged by discontinuing the suction and, advantageously, by wetting the engaged particle.

Abstract: Disclosed is an automated staining apparatus including an arm (30) moveable in three dimensions, and a hollow tip head (70) located on the arm including integral reagent tip head (40), wash tip (41) and blow tip (42) for selectively dispensing gas and liquid onto microscope slides. Also disclosed are various sub-components of the apparatus that are specifically adapted to the processing of specimens on slides.

Abstract: A classification apparatus, notably for uses in recognition or characterisation of odors, comprises a plurality of sensors for generating raw data representing a plurality of instances of a plurality of different classes; and a processing unit for processing said raw data so as to determine an identification model. The identification model comprises definitions of the classes and a particular allocation rule selected dependent upon the application. The class definitions are established by analysing data obtained during a learning phase, the analysis being performed according to a particular information extraction method. During a later identification phase, the identification model enables an instance of unknown class to be allocated to an appropriate class amongst those defined during the learning phase. The information extraction method can be selected dependent upon the application.

Abstract: The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multi-well microtiter plates or other array structures. The multi-well plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multi-well plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip.

Abstract: A highly automated, high volume multichannel pipetting system which transfers liquid from mother plates to daughter plates, or from a fill station to daughter plates. The mother plates are stacked in one set of stacker assemblies, while the empty daughter plates are stacked in another stacker assembly. A plate handling assembly which is capable of moving the plates in three orthogonal directions retrieves the plates from the stacker assemblies, carries them to the pipetting head, and returns them to other stacker assemblies. The pipetting head is removable for replacement or repair thereof, or for insertion of another head assembly having a different number of pipetting channels. The head slides into the housing on slideways, and is retained in place by manually operable, threaded knobs mounted on shafts. The stacker assemblies include a chimney which is removable from a base. The plates may be stacked in the chimney and then inserted on the base.

Abstract: A method and apparatus for controlling a stream of liquid and air segments wherein the liquid and air segments are selectively aspirated into a first fluid conduit in a plurality of cycles, each cycle beginning with the aspiration of a first air segment and ending with the aspiration of a final air segment. The liquid and air segments are then transferred from the first fluid conduit to a second fluid conduit. The volume of the final air segment of each cycle is then adjusted after the final air segment has moved into the second fluid conduit. Next, the liquid segments and the air segments of each cycle are transferred from the second fluid conduit to a third fluid conduit. The volume of the first air segment of each cycle is then adjusted after the first air segment has moved into the third fluid conduit.

Abstract: The accurate determination of the presence of a fluid in a container is determined by assessing the difference in various pressure readings relative to a threshold value. The method distinguishes between actual aspiration of a fluid and aspiration of a film that can otherwise lead one to believe that fluid has been aspirated when it has not. The method is particularly useful in clinical analyzers such as automated enzyme immunoassay devices.

Abstract: Disclosed herein is a diagnostic vessel known as a pipette. The pipette includes a main pipette housing having a hollow interior defining a first chamber and a proximal end and an open distal end. The pipette includes a pipette tip assembly connectable to the main pipette housing having a hollow interior defining a second chamber, the pipette tip hollow interior having open proximal and distal ends and the first and second chambers in fluid communication. The pipette tip includes a plunger within the second chamber. Additionally, the pipette tip assembly includes structure for normally urging the plunger to a first position such that the plunger closes the distal end of the pipette tip. The structure for normally urging the plunger to a first position also allows the plunger to be urged to a second position, wherein the plunger opens the distal end and allows fluid communication from the distal end of the pipette tip through the second chamber and into the first chamber.

Abstract: A method and apparatus therefor for depositing a flattened droplet on a partially absorbent surface comprising the steps of providing a narrow bore transfer tube having a proximal end and a distal end and containing a microvolume of liquid, the proximal end connected to a pneumatic system adapted for issuing an outgoing flow of displacement gas into the tube and drawing an incoming flow of displacement gas therefrom; and issuing an outgoing flow of displacement gas for slowly discharging substantially the entire microvolume of liquid as a droplet on the surface and controllably blowing one or more bubbles into the droplet towards the end of its discharge for flattening the droplet on the surface.

Abstract: A system for processing a plurality of solid supports comprises a tubular member having a proximal end, a distal end, and a lumen terminating at the distal end. A stop is positioned within the lumen at a location spaced about the distal end and is sized to permit fluids to pass through the lumen while preventing the passage of solid supports. A fluid transfer device is configured to transfer fluids through the lumen such that when a fluid containing one or more solid supports is aspirated into the lumen, a solid support may be drawn into the lumen to lodge against the stop.

Abstract: An analyzer comprises a conveyor which conveys sample cups and reaction cups intermixedly on a closed track, a reactor which maintains reaction cups at a predetermined temperature, a trashbin which collects used reaction cups, a nozzle unit, a reaction cup lift which carries a reaction cup between the conveyor, the reactor and the trashbin and a drive unit which drives the nozzle unit and the reaction cup lift to reciprocate, wherein the trashbin is placed on the straight track of the reaction cup lift, at least part of the closed track of the conveyor is straight and overlaps the straight track of the nozzle unit and the reaction cup lift, and the straight part of the track of the conveyor accommodates at least two cups.

Abstract: A pipette-loaded bioassay includes a measurement probe and a pipette tip. The measurement probe includes a probe head configured to launch an incident test signal and a connecting end configured to receive the incident test signal from a signal source. The pipette tip includes a sample interrogation region which is electromagnetically coupled to the probe head, the sample interrogation region configured to retain a plug of sample solution and constructed from a material which is substantially transparent to the incident test signal. The incident test signal electromagnetically couples through the sample interrogation region and to the molecular or cellular events occurring within the sample solution. The interaction of the incident test signal with the molecular or cellular events produces a modulated test signal which can be recovered and used to identify the molecular or cellular events occurring in a subsequently tested sample.

Abstract: A slotted pin tool, a delivery system containing the pin tool, a substrate for use in the system and methods using the pin tool and system are provided. The slotted pin tool contains a plurality of pins having slotted ends designed to fit around each loci of material deposited on a surface, such as a microarray, without contacting any of the deposited material. Sample is delivered by contacting the pin tool with the surface; the amount delivered is proportional to the velocity of the pin tool as it contacts the surface or the velocity of the liquid when movement of the pin is halted.

Abstract: An analyzer which comprises a conveyer which conveys sample cups and reaction cups intermixedly on a closed track, a reactor which maintains reaction cups at a predetermined temperature, a trashbin which collects used reaction cups, a nozzle unit, a reaction cup lift which carries a reaction cup between the conveyer, the reactor and the trashbin and a drive unit which drives the nozzle unit and the reaction cup lift to reciprocate, wherein the trashbin is placed on the straight track of the reaction cup lift, at least part of the closed track of the conveyer is straight and overlaps the straight track of the nozzle unit and the reaction cup lift, and the straight part of the track of the conveyer accommodates at least two cups.

Abstract: The present provides a method for analyzing a reaction test sample using test sample chips, by which a number of test sample chips can be prepared with fixing test samples of a very slight amount being disposed on each of the test sample chips of substrates at a high density, and detection of reaction test samples can be efficiently carried out with a single operation by using the corresponding test sample chips.

Abstract: The invention concerns a device for cleaning pipette needles or stirrers, the device comprising a trough which holds cleaning fluid and whose lower region has a fluid duct for filling and/or emptying purposes and whose upper region has at least one feed pipe which leads into at least one nozzle directed into the trough interior. Advantageously, the device has a cylindrical trough and an insert with nozzles which is screwed into the trough. The invention further concerns a method of cleaning pipette needles or stirrers, the material to be washed being introduced into the trough interior and sprayed with a washing fluid. The device can also be used to flush the interior of a pipette needle.

Abstract: A method and apparatus is provided for depositing a flattened droplet on a surface. The method includes the steps of providing a tube with a distal end that contains a microvolume of liquid, issuing an outgoing flow of displacement gas for slowly discharging substantially the entire microvolume of liquid as a droplet on the surface, and controllably blowing one or more bubbles into the droplet for flattening the droplet on the surface.

Abstract: A pipetting station having a bottom sensing device is provided in conjunction with one of any known liquid level sensing devices. The bottom sensing device includes a pipetting probe spring mounted to a pipetting arm of the pipetting station. The bottom sensing device also includes a sensor for determining when a pipetting tip of the pipetting probe is in contact with a bottom of a tube. The bottom sensing device permits the pipetting probe to measure an exact volume of fluid in the tube by allowing the pipetting tip to be lowered to the bottom of the tube beyond the sensed fluid level.

Abstract: An automatic analysis apparatus with a liquid level detection function includes a pipetting device for pipetting a liquid sample from a sample cup to a reaction container by using a pipetting probe that serves as a first capacitor electrode. A sample cup holding means serves as a second capacitor electrode having a ground potential. The conductor material is arranged along a direction in which the pipetting probe moves down for pipetting and is separate from the pipetting device. The conductor material has the same ground potential as that of the sample cup holding means and also serves as a second electrode whereby at any one time either of the sample cup holding means and the conductive material serves as a second capacitor electrode in combination with the first capacitor electrode.

Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.

Abstract: A headspace sampling apparatus collects headspace vapor from a container holding a vapor phase and a non-vapor phase of a substance which is to be analyzed. The apparatus includes a dual needle apparatus (55). The dual needle apparatus is extended through a septum into a headspace portion (57) of a vial (58) holding the substance for analysis. A purge gas is supplied to a first fluid passage (54) in the dual needle. The purge gas sweeps the material in the headspace and passes the sample through a send fluid passage (56) in the needle. The extracted sample is selectively directed through a six port valve (76). In a first condition of the valve the sample is directed to a trap (80) for collection therein. After sample collection the condition of the six port valve is changed. Material is desorbed from the trap and directed through the valve into an analytical instrument (82).

Abstract: The present invention is directed to the use of deposited thin films for chemical or biological analysis. The invention further relates to the use of these thin films in separation adherence and detection of chemical of biological samples. Applications of these thin films include desorption-ionization mass spectroscopy, electrical contacts for organic thin films and molecules, optical coupling of light energy for analysis, biological materials manipulation, chromatographic separation, head space adsorbance media, media for atomic molecular adsorbance or attachment, and substrates for cell attachment.

Abstract: An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.

Abstract: A method and apparatus for controlling a stream of liquid and air segments wherein the liquid and air segments are selectively aspirated into a first fluid conduit in a plurality of cycles, each cycle beginning with the aspiration of a first air segment and ending with the aspiration of a final air segment. The liquid and air segments are then transferred from the first fluid conduit to a second fluid conduit. The volume of the final air segment of each cycle is then adjusted after the final air segment has moved into the second fluid conduit. Next, the liquid segments and the air segments of each cycle are transferred from the second fluid conduit to a third fluid conduit. The volume of the first air segment of each cycle is then adjusted after the first air segment has moved into the third fluid conduit.

Abstract: In order to surely and correctly detect the liquid level of the sample even if the sample cup (5) is not directly set on the sample disk (105), the cup (5) is mounted on the test tube (6) set on the sample disk (105) and moved to a sample pipetting position. A conductive material served as a liquid level detecting electrode is provided between the sample pipetting probe and said sample disk (105). The sample pipetting probe start to move down, and when tip of the sample pipetting probe contact with the liquid level, and change of an electrostatic capacitance between the conductive material and the sample pipetting probe is detected, the moving down motion of the sample pipetting probe is stopped.

Abstract: The invention provides printing systems and methods for depositing small volumes of liquid on solid substrates. These systems and methods are useful with a wide variety of liquids and substrates and offer a wide variety of applications, including the deposition of arrays of analytes. In particular embodiments, the systems comprise a preservation device, a detachable ganged plurality of printing devices, and/or a wire bonding capillary.

Abstract: A test sample card is provided with a locking feature for achieving a positive, locking engagement with a transfer tube that conducts fluid into the interior of the test sample card. The locking feature consists of a tubular channel inwardly disposed from the fluid intake port that has an inner annular rim defining a restriction. The annular rim is of a reduced diameter relative to the diameter of the transfer tube. A recessed region is positioned inwardly from the restriction that has an opening in one of the surfaces of the card body. When the transfer tube is inserted into the tubular channel, the first end is forced past the restriction into the recessed region, with the annular rim compressing the transfer tube. The user is able to sense with their hands when the first end is inserted past the restriction. Visual observation of the first end of the transfer tube through the opening in the card surface confirms that the transfer tube has been properly inserted into the test sample card.

Abstract: A pipet provides for dispensing a fluid medium into an open-ended collection container including an improved dripless tip. The pipet includes a tip body with a cross shaped passage structure that spans the length of the tip body. This cross shaped passage structure is designed to contact the liquid medium that passes into the tip and onto the open distal end of the tip and prevent unwanted dripping therefrom.

Abstract: In a testing system for chemical substances or substance mixtures, especially for potential plant protection compositions, the chemical substance to be tested or the substance mixture to be tested is applied to a test specimen, especially to plants or parts of plants. When a predetermined period of time has elapsed, the test specimen is examined for the activity of the substance or substance mixture. For this purpose, first of all a type of test specimen is selected from a stock of test specimens, and the substances to be tested are selected from a stock of substances to be tested. The selected type of test specimen and the selected substances are identified (BC1, BC2) with a machine-readable code and those codes are supplied to a memory unit (12).

Abstract: The invention relates to a diagnostic medical device, and in particular to a blood cell analyzer which by manual or automatic operation withdraws and analyzes a minimal amount of blood that is stored in open or sealed vials. The analyzer includes a manually operated self cleaning sampling device for open vials and an automated self cleaning sampling device for sealed vials fitted with a pierceable cap.

Abstract: A mixture of beads from a combinatorial library is held in suspension in a liquid by movement of the liquid induced by a vertically reciprocating paddle. The tips of needles in an array are immersed in the suspension, a slot being provided in the paddle to avoid collision with the needles. Liquid is drawn into the needles until a bead becomes attached to the tip of each needle. Excess beads adhering to the needles are shaken off by an electromagnetically operated vibrator, and the beads are deposited in wells of a well plate by applying a short burst of pressure to the interiors of the needles. Liquid and any debris within the needles are thereafter discharged to a receptacle by applying a higher pressure burst to the interiors of the needles.

Abstract: The present device is directed to a reagent transfer device for transferring a plurality of reagent samples from one location to another. A transfer plate has a top surface with reservoirs, a bottom surface with orifices, and channels connecting the reservoirs and orifices. Fluid is moved from the reservoirs, through the channels and out of the orifices to form samples on the bottom surface about the orifices. A movement apparatus is provided for bringing the samples into contact with deposit surfaces at various deposition positions. Arrays of at least 100 orifices per square centimeter are provided.

Abstract: A work station for simultaneously performing multiple assays includes a base structure, a receptacle rack assembly received within a receptacle rack well formed in the base structure, a pipette tip rack assembly received within a pipette tip rack well formed in the base structure, a multiple conduit substance transfer device, and substance transfer device positioning structure. The receptacle rack assembly holds a plurality of receptacles in which a plurality of individual assays are performed, and the pipette tip rack assembly holds a plurality of contamination limiting pipette tips. The substance transfer device is capable of simultaneously dispensing substances into two or more receptacles or simultaneously removing substances from two or more receptacles. Alternatively, the substance transfer device is capable of simultaneously dispensing substances into two or more receptacles, and, at about the same time, simultaneously removing substances from two or more receptacles.

Abstract: A method and apparatus for detecting improper liquid content of a metering tip of an analyzer. The method detects the content or status using radiation between 630 and 2000 nm, and comprises the steps of: a) aspirating the liquid into the tips; b) scanning the liquid; c) providing relative motion between the tip and the scanner while simultaneously scanning the liquid; d) detecting the amount of light transmitted to detector at all levels of the liquid; e) comparing the detected light with light known to be transmitted at levels of liquid free of air bubbles; and flagging the results.

Abstract: A magnetic material attracting/releasing control method makes use of a pipette device sucking a liquid from or discharging a liquid into a container. A magnet body or bodies are provided in a liquid suction line of the pipette device, and any magnetic material contained in liquid sucked into the liquid suction line by magnetic force are deposited on the internal surface of the line. The magnetic material is released and discharged together with liquid from the liquid suction line to a state where the effect of the magnetic force generated by the magnet body is cut off.

Abstract: Apparatus for producing a plurality of arrays of reagent regions is disclosed. A dispensing assembly in the apparatus has a plurality of heads which are spaced for depositing reagents at selected positions in different array areas in a substrate. As the heads in the assembly are advanced along array area, the regions in a row in that array are successively filled, allowing parallel deposition in several array areas at reagent regions which are closely spaced relative to the spacing between deposition heads in the assembly. Also disclosed is a method for producing a plurality of arrays using the apparatus.

Abstract: A method for separating serum from whole blood in a vessel at an insertion speed of 30 cm/sec or less and maintaining the suction pressure of the suction nozzle at 400 mm Hg or less. Improved analytical results are obtained because the serum can be produced without hemolysis.

Abstract: A high precision, small volume fluid processing system employs open ended capillary tubes to meter, aliquot and mix small volumes of sample fluid and reagents. The system has an automatic mechanism for moving the capillary tubes as well as automated sub-systems for incubating and mixing fluids within the capillary tubes.

Abstract: The piston burette for storing and dispensing a reagent used in analytical or metering work includes a calibrated burette cylinder (11) and a piston (13) slidably mounted in it.

Abstract: A chemical analyzing apparatus comprises a reaction cell holder which holds a plurality of reaction cells that are supplied with samples and reagents at a predetermined position, a measurer for measuring characteristics of the sample, a plurality of reagent containers, a liquid deliverer provided below each of the plurality of reagent containers, one or more sound wave generators provided outside the reaction cells, and storage containers for storing cleansing liquid with different contamination states. The cleansing liquid with different contamination states is reused according to the contamination levels of the reaction cells.

Abstract: Heretofore, there has been demanded an automatic analysis apparatus which can prevent cross-contamination between reagents, which can prevent dust and gas from entering a reagent supply device, which can always know a remaining quantity of the reagent while can reduce the quantity of waste. According to the present invention, there is provided an automatic analysis apparatus in which a reagent supply device for supplying a reagent from a reagent container into a reaction container is removably attached to the reagent container, a protective door is provided in the reagent supply port in order to aim at preventing dust from entering the reagent supply device, and further the reagent container and the reagent supply device are provided with recording mediums for recording therein conditions thereof, a time of replacement thereof or the like, and which can inform whether the setting is proper or not.