Glucose Patents (Class 436/95)
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Patent number: 8975080Abstract: A biosensor calibration method configured to measure a concentration of a specific substance contained in sample liquid to be measured, including: a first step configured to acquire a first output value that is output by the biosensor when first calibration liquid is brought into contact with the biosensor; a second step configured to acquire a second output value that is output by the biosensor when second calibration liquid having a different concentration from that of the first calibration liquid is continuously brought into contact with the biosensor after the first step and determine time for replacement of the biosensor on the basis of the first output value and the second output value.Type: GrantFiled: March 14, 2013Date of Patent: March 10, 2015Assignee: Tanita CorporationInventors: Satoshi Ikeda, Mariko Kose, Tatsuro Murayama, Yuri Kinoshita
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Publication number: 20150064732Abstract: An analytical test cartridge is provided. The analytical test cartridge can be used for medical analyses of liquid samples removed from a patient, for example blood. The analytical test cartridge is configured to provide for titration experiments. An example of a titration experiment that can be performed with the arrangement, is titration of heparin with protamine. Methods of assembly and use are provided.Type: ApplicationFiled: February 28, 2014Publication date: March 5, 2015Inventor: Kee Van Sin
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Patent number: 8940538Abstract: The present invention relates to an apparatus for quantifying the binding and dissociation kinetics of molecular interactions of small molecular bio materials with high sensitivity almost without the influence of a change in the reflective index resulting from a buffer solution by making polarized incident light incident on the binding layer of a bio material, formed in a thin dielectric film, so that the polarized incident light satisfies a p-wave non-reflecting condition and a quantifying method using the same.Type: GrantFiled: October 29, 2010Date of Patent: January 27, 2015Assignee: Korea Research Institute of Standards and ScienceInventors: Hyun Mo Cho, Gal Won Che, Yong Jai Cho
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Patent number: 8940542Abstract: A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed to the membrane; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.Type: GrantFiled: October 8, 2013Date of Patent: January 27, 2015Assignee: Lighthouse Medical LimitedInventors: William Paterson, Nick Barwell, Bruce Culbert, Barry Colin Crane
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Patent number: 8940540Abstract: A portable, hand-held glucose testing device includes a housing configured to accommodate a plurality of test sensors in a stacked arrangement and having a wall with an opening defined therein. A plurality of packaged test sensors is stacked in alignment with one another within the housing. Each of the test sensors is packaged within a blister package. The blister package includes a blister package housing and a cover foil overlying a surface of the blister package housing and the test sensor. A drive slide is configured to displace one of the plurality of packaged test sensors out of alignment with other packaged test sensors. A knife mechanism is configured to pierce through the cover foil, and to engage and urge the test sensor to extend through the opening for receiving a sample. A meter contact is configured to engage the test sensor when the test sensor extends through the opening.Type: GrantFiled: March 12, 2013Date of Patent: January 27, 2015Assignee: Bayer HealthCare LLCInventors: Steven C. Charlton, Allen Brenneman
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Patent number: 8927490Abstract: Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis, which is the % of glucose production that comes from gluconeogenesis (“GNG”), as opposed to glycogenolysis (“GLY”), the other form of glucose production. Nutritional formulations, materials, cocktails and methods for feeding patients by parenteral and other means are disclosed. The amount, type and rate of such nutritional feeding are typically based upon the above estimating. The invention discloses formulations that contain labels, such as deuterium, for medical diagnostics, such as for estimating BES and fractional gluconeogenesis.Type: GrantFiled: August 2, 2013Date of Patent: January 6, 2015Assignee: Run Them Sweet, LLCInventors: Michael A Horning, George A Brooks
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Patent number: 8917184Abstract: Various systems and methods of operating an analyte measurement device is provided. The device has a display, user interface, processor, memory and user interface buttons. In one example, one of the methods can be achieved by measuring an analyte with the analyte measurement device; displaying a value representative of the analyte; prompting a user to activate a test reminder; and activating the test reminder to remind a user to conduct a test measurement at a different time. Other methods and systems are also described and illustrated.Type: GrantFiled: March 20, 2009Date of Patent: December 23, 2014Assignee: Lifescan Scotland LimitedInventors: Antony Smith, Alistair Longmuir, Allan Faulkner
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Patent number: 8906305Abstract: An instrument adapted to determine an analyte concentration of a fluid sample using a test sensor is disclosed. The instrument comprises a display adapted to display information to a user, a user-interface mechanism adapted to allow the user to interact with the instrument, a first test-sensor cartridge, and a body portion including at least a first opening and a second opening formed therein. The first opening is adapted to receive a test sensor from the first test-sensor cartridge. The second opening is adapted to store at least one additional test-sensor cartridge.Type: GrantFiled: March 12, 2007Date of Patent: December 9, 2014Assignee: Bayer HealthCare LLCInventors: Allen J. Brenneman, Huan-Ping Wu
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Publication number: 20140349326Abstract: Apparatus and methods are provided for analyzing a medical condition of a user. The apparatus may include a user interface configured to receive user identification information inputted by the user, an analyzer, and a processor all disposed within a common housing. The analyzer is configured to receive a biological specimen from the user and to analyze the biological specimen to generate analysis information. The processor is configured to store and forward the analysis information and to receive prescription information. The apparatus may include a communication unit configured to transmit the user identification information and the analysis information to a doctor at a remote location for review and to receive the prescription information from the doctor. The apparatus then may dispense the prescribed medication or print a medication prescription.Type: ApplicationFiled: February 6, 2013Publication date: November 27, 2014Inventor: Michael INGBER
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Patent number: 8895315Abstract: Persons with diabetes often carry a handheld glucose meter as well as a portable computing device, such as a mobile phone. Given the close proximity of these two devices, the portable computing device can serve as a data collector for the glucose measures taken by the glucose meter. Improved techniques are set forth for transferring glucose measures automatically and seamlessly to the patient's portable computing device, including displaying a value for the glucose measure along with an identifier for the portable computing device on a display of the glucose meter during the data exchange with the portable computing device.Type: GrantFiled: March 12, 2013Date of Patent: November 25, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Carol J. Batman, Stacia Davis, David B. Markisohn, Erin K. McKinney, Mark G. Mears, Amy S. Stanley, Benjamin E. Strickrod
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Patent number: 8895316Abstract: Persons with diabetes often carry a handheld glucose meter as well as a portable computing device, such as a mobile phone. Given the close proximity of these two devices, the portable computing device can serve as a data collector for the glucose measures taken by the glucose meter. Improved techniques are set forth for transferring glucose measures automatically and seamlessly to the patient's portable computing device, including transmitting a single glucose measure automatically in response to navigating away from an interface which displays to the glucose measure.Type: GrantFiled: March 12, 2013Date of Patent: November 25, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Carol J. Batman, Craig L. Carlson, Michael J. Celentano
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Publication number: 20140322815Abstract: A diabetes management system includes a handheld medical device, a mobile computing device, and a diabetes management application. The handheld medical device is configured to determine, in response to a port receiving a test strip, whether an auto-send feature is enabled on the handheld medical device, determine whether the handheld medical device is paired with a mobile computing device, and selectively instruct a wireless transceiver to establish a wireless connection and communicate a glucose measurement and identifying information to the mobile computing device. The mobile computing device is configured to execute the diabetes management application. The diabetes management application is configured to process a plurality of glucose measurements and identifying information associated with each of a plurality of glucose measurements.Type: ApplicationFiled: February 4, 2014Publication date: October 30, 2014Applicant: Roche Diagnostics Operations, Inc.Inventors: Eric S. Carlsgaard, David B. Markisohn, Mark Mears
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Patent number: 8871517Abstract: A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.Type: GrantFiled: December 13, 2013Date of Patent: October 28, 2014Assignee: Bayer Healthcare LLCInventors: Jing Lin, Fu Hsiung Tsai, Huan-Ping Wu, Nicole D. Ellis, Henry C. Arndt
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Patent number: 8865071Abstract: A test tape device is disclosed herein for use with a replaceable analytical tape cassette, where the device includes a housing having a cassette compartment covered by a cassette door and a housing opening for sample application, a protective cover that can be moved between a closed position covering the housing opening and a release position allowing access to the housing opening and a door lock for retaining the cassette door in the closed position, wherein the protective cover is coupled with the door lock via an interlocking mechanism, such that the door lock can only be unlocked in the release position of the cover.Type: GrantFiled: June 5, 2013Date of Patent: October 21, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Hao-Chih Lin, Wen Tsung Wang
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Patent number: 8859292Abstract: A sensor chip is configured to measure the temperature of a blood sample and includes a capillary section and an electrode unit. The capillary section allows the blood sample to be introduced therein. The electrode unit is configured to measure the temperature of the blood sample and includes a working electrode and a counter electrode. The working electrode and the counter electrode respectively include a reaction reagent layer containing an electrolyte. Further, the electrode unit is configured to receive a predetermined voltage to be applied in measuring the temperature of the blood sample for allowing a result of the measurement to be less affected by increase and reduction in a glucose concentration and the like.Type: GrantFiled: January 28, 2010Date of Patent: October 14, 2014Assignee: Panasonic Healthcare Co., Ltd.Inventor: Masaki Fujiwara
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Patent number: 8841133Abstract: A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.Type: GrantFiled: May 2, 2013Date of Patent: September 23, 2014Assignee: Bayer HealthCare LLCInventors: Huan-Ping Wu, Christine D. Nelson
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Publication number: 20140273257Abstract: Persons with diabetes often carry a handheld glucose meter as well as a portable computing device, such as a mobile phone. Given the close proximity of these two devices, the portable computing device can serve as a data collector for the glucose measures taken by the glucose meter. Improved techniques are set forth for transferring glucose measures automatically and seamlessly to the patient's portable computing device, including transmitting a single glucose measure automatically in response to navigating away from an interface which displays to the glucose measure.Type: ApplicationFiled: March 12, 2013Publication date: September 18, 2014Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Carol J. Batman, Craig L. Carlson, Michael J. Celentano
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Publication number: 20140273043Abstract: The present disclosure relates to an optical fluorescence sensor comprising a probe for sensing glucose, an intra-reference probe, and a matrix. The present disclosure also relates to an optical fluorescence dual sensor comprising a probe for sensing glucose, a probe for sensing oxygen, an intra-reference probe, and a matrix. The present disclosure additionally relates to methods of preparing these sensors and methods of using them.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Inventors: Yanqing Tian, Liqiang Zhang, Fengyu Su, Deirdre Meldrum, Sean Buizer
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Publication number: 20140273256Abstract: Persons with diabetes often carry a handheld glucose meter as well as a portable computing device, such as a mobile phone. Given the close proximity of these two devices, the portable computing device can serve as a data collector for the glucose measures taken by the glucose meter. Improved techniques are set forth for transferring glucose measures automatically and seamlessly to the patient's portable computing device, including displaying a value for the glucose measure along with an identifier for the portable computing device on a display of the glucose meter during the data exchange with the portable computing device.Type: ApplicationFiled: March 12, 2013Publication date: September 18, 2014Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Carol J. Batman, Stacia Davis, David B. Markisohn, Erin K. McKinney, Mark G. Mears, Amy S. Stanley, Benjamin E. Strickrod
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Publication number: 20140255962Abstract: Test elements are disclosed for detecting at least one analyte in a body fluid. The test element include at least one strip-shaped carrier element and at least one test field having at least one test chemistry for detecting the analyte. The test element has a symmetrical shape such that the test element may be inserted in one of at least two different correct measurement orientations into a test element receptacle of a testing device, which includes a detection device. In the different orientations, at least one analyte-induced change in the test chemistry of the test field is detectable. Test systems including the test elements and methods of detecting at least one analyte in the body fluid using the test elements also are disclosed.Type: ApplicationFiled: May 22, 2014Publication date: September 11, 2014Applicant: Roche Diagnostics Operations, Inc.Inventors: Frank Rueckert, Bruno Thoes
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Patent number: 8821811Abstract: Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated.Type: GrantFiled: September 26, 2012Date of Patent: September 2, 2014Assignee: Google Inc.Inventors: Zenghe Liu, James Etzkorn
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Publication number: 20140242710Abstract: Methods of covalently attaching heparin to a membrane comprising plasma treating the membrane to produce an amino-functionalized membrane; and reacting the amino-functionalized membrane with heparin under conditions in which heparin becomes covalently attached to the amino-functionalized membrane, wherein said heparin is indirectly attached via a spacer to said amino-functionalized membrane and/or said heparin is attached from a single site in said heparin to a single site on said amino-functionalized membrane or to said spacer. Also disclosed are analyte sensors.Type: ApplicationFiled: September 25, 2012Publication date: August 28, 2014Inventors: Jeff T. Suri, Eric Patterson
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Patent number: 8815178Abstract: The invention relates to a device and method for non-invasive detection of an analyte in a fluid sample. In one embodiment, the device comprises: a collection chamber containing an absorbent hydrogel material; a fluidic channel connected to the collection chamber; a sensing chamber connected to the fluidic channel, wherein the device is comprised of a compressible housing that allows transfer of fluid collected by the collection chamber to be transferred to be extracted and withdrawn to the sensing chamber upon compression of the device, wherein the sensing chamber contains a material that specifically detects the analyte and wherein the sensing chamber is operably linked to a processor containing a potentiostat that allows detection of the analyte using electrochemical sensing.Type: GrantFiled: March 25, 2010Date of Patent: August 26, 2014Assignee: Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Daniel Bishop, Jeffrey La Belle
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Publication number: 20140234982Abstract: A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed to the membrane; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.Type: ApplicationFiled: October 8, 2013Publication date: August 21, 2014Applicant: Lightship Medical LimitedInventors: William Paterson, Nick Barwell, Bruce Culbert, Barry Colin Crane
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Publication number: 20140227794Abstract: The present invention provides a time synchronization method for a diagnostic strip analysis apparatus. When a user sets time of the diagnostic strip analysis apparatus, time setting information is stored in a storage unit of the diagnostic strip analysis apparatus. Biological information is measured using the diagnostic strip analysis apparatus. The time setting information and measured amounts and measurement times of the biological information are simultaneously stored in the storage unit. The time setting information, the measured amounts and the measurement times, together with transmission times, are transmitted to a management medium. A control unit of the management medium determines whether time of the diagnostic strip analysis apparatus has been set. If the time of the diagnostic strip analysis apparatus has been set, the time setting information, the measured amounts, the measurement times, and the transmission times are stored in a storage unit of the management medium.Type: ApplicationFiled: April 28, 2011Publication date: August 14, 2014Applicant: PHILOSYS CO., LTD.Inventors: In Hwan Choi, Jeong In Bag, Su Hwan Kim
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Patent number: 8795595Abstract: A sensing apparatus may include a substrate having a first side for a sensing element and a second side for electronics, the substrate may have a at least one via from the first side of the substrate to the second side of the substrate, the at least one via may be hermetically sealed with an optically transmissive material.Type: GrantFiled: April 30, 2010Date of Patent: August 5, 2014Assignee: Medtronic Minimed, Inc.Inventor: Rajiv Shah
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Patent number: 8772044Abstract: The present invention provides a method for obtaining structural information conveniently and rapidly by generating a negative ion without adding an acidic substance to matrix, thereby improving sensitivity of measurement by a mass spectrometer, and by generating structural specific ions with high reproducibility, and a method for screening disease marker and a method for analyzing a sample containing a biomolecule. A method for mass spectrometry of a sugar chain comprising the steps of: preparing a sample containing a sugar chain; labeling the sugar chain with a labeling compound, to obtain a labeled sugar chain; and subjecting the labeled sugar chain to measurement of negative ions by using a MALDI mass spectrometer, thereby conducting analysis of the sugar chain.Type: GrantFiled: March 27, 2006Date of Patent: July 8, 2014Assignees: The Noguchi Institute, Shimadzu CorporationInventors: Junko Amano, Koichi Tanaka
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Publication number: 20140186820Abstract: Use of a programmable device with capacitive touch screen for the analysis of a fluid sample as interface between a micro-fluidic device, this micro-fluidic device comprising at least one electrode and at least one micro-channel comprising an input for the introduction of the sample, and the processor of said programmable device with a capacitive touch screen.Type: ApplicationFiled: December 9, 2011Publication date: July 3, 2014Inventor: Arthur Queval
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Patent number: 8765484Abstract: The invention concerns a particle having a code embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum.Type: GrantFiled: January 31, 2003Date of Patent: July 1, 2014Assignee: The Regents of the University of CaliforniaInventors: Michael J. Sailor, Thomas Schmedake, Frederique Cunin, Jamie Link
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Patent number: 8765482Abstract: A test strip with a sample chamber is secured to a meter. The sample chamber in the portion of the test strip that extends out of the meter is illuminated by transmitting light from a light source inside the meter internally through the test strip towards the sample chamber. By way of analogy, the test strip acts in a fashion similar to a fiber optic cable or optical wave guide by transmitting the light from the meter to the remotely located sample chamber that extends outside the meter. The user is then able to easily see the sample chamber of the test strip in dark conditions so that the user is able to readily align the sample chamber with the drop of fluid on the skin as well as view the sample chamber in order to ensure proper filling. The light also illuminates a test strip slot into which the test strip is inserted.Type: GrantFiled: March 12, 2013Date of Patent: July 1, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Abner D. Joseph, Brian A. Heald
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Publication number: 20140179012Abstract: A method of analyzing a blood sample is provided. The method comprises providing a system configured to perform an analysis of a glucose level of the blood sample disposed on a test medium, wherein the test medium is one of a quantity of test media in a user's supply, monitoring, by the system, the number of test media of the supply used in performing the analysis, determining, by the system, that a threshold value of test media has been reached, the threshold value being less than the quantity, and performing, by the system, once the threshold value has been reached, an ordering procedure.Type: ApplicationFiled: December 19, 2013Publication date: June 26, 2014Inventors: DOV MORAN, YIFTAH BEN AHARON
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Publication number: 20140179013Abstract: A method of analyzing a blood sample is provided. The method comprises providing a glucometer configured to analyze a blood sample and a remote computing device separate from the glucometer, analyzing, by the glucometer, the blood sample, and presenting, by the glucometer, encoded results. The encoded results may be presented as a machine-readable visually-encoded representation of one or more results of the analysis, in which case the method further comprises imaging, by the remote computing device, the representation. The encoded results may be presented as a capacitive profile, in which case the method further comprises reading, by a capacitive sensing input mechanism of the remote computing device, the capacitive profile. According to either option, the method further comprises decoding, by the remote computing device, the representation, thereby retrieving at least one of the results.Type: ApplicationFiled: December 19, 2013Publication date: June 26, 2014Inventors: DOV MORAN, YIFTAH BEN AHARON, ITAY COHEN, ROEE TUVAL
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Publication number: 20140170761Abstract: A smartphone protective cover that houses a glucose monitor, test strips, lancets, a lancet striker, a power source, and a biohazard debris receptacle is presented. According to the preferred embodiment of the invention, the protective covering is configured to include a smartphone adapted glucose monitor and also to accept a smartphone. In the preferred embodiment, the smartphone is removably placed into the protective covering with the glucose monitor connecting to a data receptacle on the smartphone. The protective further includes a lancet storage compartment adjacent to a lancet striker having a tension control member and striker release button, a test strip storage compartment, and a biohazard debris receptacle. The lancet storage compartment and test strip storage compartment can be re-fillable or disposable. A battery is also located in the cover and is electrically connected to the glucose for monitor, thus enabling the monitor to be powered independently of the phone.Type: ApplicationFiled: December 18, 2012Publication date: June 19, 2014Inventors: Spencer Crawford, Michael Landis
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Method and apparatus for estimating features of target materials by using kinetic change information
Patent number: 8725427Abstract: Disclosed are a method and an apparatus for estimating the features (concentration, weight, volume, etc.) of target materials, by using kinetic change information along time, when measuring the results of a chemical reaction between two materials, target materials and reactant, with an optical or electrochemical method.Type: GrantFiled: January 21, 2009Date of Patent: May 13, 2014Inventor: Yong Gwan Won -
Publication number: 20140127821Abstract: An analyte measurement system is provided having sensors with embossed test chamber channels. In one embodiment, the sensors are elongate test strips for in vitro testing, each test strip having a substrate, at least one electrode, an embossed channel in the electrode, and lidding tape covering at least a portion of the embossed channel. Methods of manufacture are also disclosed for filling the sensor channels with reagent, and for trimming the ends of the sensors to eliminate the need for a calibration code during use of the sensors with a meter.Type: ApplicationFiled: January 14, 2014Publication date: May 8, 2014Applicant: Abbott Diabetes Care Inc.Inventors: Adrian Petyt, Simon A. Hector
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Patent number: 8716024Abstract: A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.Type: GrantFiled: November 20, 2012Date of Patent: May 6, 2014Assignee: Bayer HealthCare LLCInventors: Jing Lin, Fu Hsiung Tsai, Huan-Ping Wu, Nicole D. Ellis, Henry C. Arndt
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Publication number: 20140120206Abstract: Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis, which is the % of glucose production that comes from gluconeogenesis (“GNG”), as opposed to glycogenolysis (“GLY”), the other form of glucose production. Nutritional formulations, materials, cocktails and methods for feeding patients by parenteral and other means are disclosed. The amount, type and rate of such nutritional feeding are typically based upon the above estimating. The invention discloses formulations that contain labels, such as deuterium, for medical diagnostics, such as for estimating BES and fractional gluconeogenesis.Type: ApplicationFiled: May 28, 2013Publication date: May 1, 2014Inventors: Michael A. Horning, George A. Brooks
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Publication number: 20140120238Abstract: Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis, which is the % of glucose production that comes from gluconeogenesis (“GNG”), as opposed to glycogenolysis (“GLY”), the other form of glucose production. Nutritional formulations, materials, cocktails and methods for feeding patients by parenteral and other means are disclosed. The amount, type and rate of such nutritional feeding are typically based upon the above estimating. The invention discloses formulations that contain labels, such as deuterium, for medical diagnostics, such as for estimating BES and fractional gluconeogenesis.Type: ApplicationFiled: August 2, 2013Publication date: May 1, 2014Applicant: Run Them Sweet, LLCInventors: Michael A. Horning, George A. Brooks
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Publication number: 20140121173Abstract: Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis, which is the % of glucose production that comes from gluconeogenesis (“GNG”), as opposed to glycogenolysis (“GLY”), the other form of glucose production. Nutritional formulations, materials, cocktails and methods for feeding patients by parenteral and other means are disclosed. The amount, type and rate of such nutritional feeding are typically based upon the above estimating. The invention discloses formulations that contain labels, such as deuterium, for medical diagnostics, such as for estimating BES and fractional gluconeogenesis.Type: ApplicationFiled: August 2, 2013Publication date: May 1, 2014Applicant: Run Them Sweet, LLCInventors: Michael A. Horning, George A. Brooks
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Patent number: 8709829Abstract: The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations.Type: GrantFiled: August 20, 2012Date of Patent: April 29, 2014Assignee: The Johns Hopkins UniversityInventors: David H. Gracias, Timothy Gar-Ming Leong, Hongke Ye
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Patent number: 8703499Abstract: The application provides a laboratory. The laboratory (400) comprises a portable casing (404). The portable casing (404) comprises a tray unit (407), an actuator unit (405, 412), an analyzer unit (419), and a communication unit (402, 415, 438). The tray unit (407) is used for receiving a cartridge (409). The cartridge (409) comprises an analyte reservoir (430) for receiving an analyte fluid, one or more chemical reagent reservoirs (432) for storing one or more chemical reagent fluids, and one or more channels (434) connecting the chemical reagent reservoirs (432) with the analyte reservoir (430). The channel (434) comprises a measurement area (436) while the measure measurement area (436) comprises a sensor. The actuator unit (405, 412) is used for reducing the volume of the analyte reservoir (430) and for reducing the volume of the chemical reagent reservoirs (432). The analyzer unit (419) is used for measuring a physical value in the measurement area (436) using the sensor.Type: GrantFiled: April 27, 2010Date of Patent: April 22, 2014Assignee: E-Vitae Pte. Ltd.Inventor: Mehdi Khaled
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Patent number: 8691152Abstract: A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.Type: GrantFiled: February 2, 2012Date of Patent: April 8, 2014Assignees: Roche Operations Ltd., Roche Diagnostics Operations, Inc.Inventors: David W. Burke, Lance S. Kuhn, Terry A. Beaty, Vladimir Svetnik
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Publication number: 20140093896Abstract: A point-of-care, screening kit for use by a heath care worker to create custom test strips for screening the bodily fluids of an individual for various, medical conditions includes: (a) a plurality of reagents (12), (b) a substrate (18) configured to: i) receive one of the reagents and react with it so as to cause it to acquire a first characteristic color, and, ii) upon the addition of the individual's bodily fluid to the substrate, acquire, as a result of the formulation of each of the reagents, a second, dichotomous characteristic color when the individual has a specific one of the various, medical conditions.Type: ApplicationFiled: May 7, 2012Publication date: April 3, 2014Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Sean Mongale, Shishira Nagesh, Ezra Taylor, Mary O'Grady, Thembi Mdluli, Peter Truskey, Sherri Hall, James Waring, III, Britni Crocker, Harshard Sanghvi, Elaine Yang, Soumyadipta Acharya, Maxim Budyansky, Matthew Means
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Patent number: 8685739Abstract: There is provided a method of diagnosing a disease state in a subject. The disease state is caused or effected by pneumococcal infection. The method includes obtaining a biological test sample from the subject. The biological sample includes at least one metabolite selected from the group consisting of citrate, trigonelline, acetylcarnitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine. A respective concentration of each one of the at least one metabolite is compared with a predetermined concentration value associated with a corresponding one of the at least one metabolite. The predetermined concentration value is indicative of the disease state. For example, the biological sample includes any one of citrate, trigonelline, acetylcamitine, acetone, myoinositol, 3-hydroxybutyrate, glucose and carnitine. As a further example, the biological samples include any combination of citrate, trigonelline, acetylcamitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine.Type: GrantFiled: April 14, 2008Date of Patent: April 1, 2014Inventors: Carolyn Slupsky, Thomas Marrie
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Patent number: 8673214Abstract: A portable apparatus for measuring a glucose level of a user having: a card-like member; a processor within the card-like member; at least one glucose sensor comprising a reagent, the glucose sensor generating a signal indicative of a measured glucose level upon application of a blood sample to the glucose sensor, wherein the glucose sensor is fixed to the card-like member and operably coupled to the processor; and at least one cover alterable between a first position in which the glucose sensor is covered and a second position in which the glucose sensor is exposed for use.Type: GrantFiled: March 22, 2011Date of Patent: March 18, 2014Assignee: iMPak Health, LLCInventors: Salvatore Richard Inciardi, Sandra D. Elliott, Jonas Sven-Erik Tiren, Per Nathanaelson, Jakob Ehrensvärd
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Publication number: 20140057359Abstract: The invention relates to an apparatus and a method for analyzing sample fluids, in particular for analyzing blood samples, for example for the purpose of determining the glucose content, with the same apparatus. A cavity delimited by a carrier tape is hereby positioned above a sensor surface, sample fluid is received in the cavity, at least one value of the sample fluid is measured, the cavity containing the sample fluid is removed from the sensor surface, and a regeneration agent is supplied to the sensor surface by way of the carrier tape.Type: ApplicationFiled: March 5, 2012Publication date: February 27, 2014Inventors: Dorothea Zahn, Frank Bier
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Patent number: 8658795Abstract: Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.Type: GrantFiled: April 25, 2012Date of Patent: February 25, 2014Assignee: Glumetrics, Inc.Inventors: Soya Gamsey, Ritchie A. Wessling
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Patent number: 8641972Abstract: The present invention provides a method for measuring a substrate concentration by accumulating an energy resulting from a reaction between a biocatalyst and a substrate recognized by the biocatalyst to a certain level; and using a dependency of an accumulation rate on the substrate concentration as an index; and a apparatus therefor. In particular, the present invention provides a method in which the measurement of the accumulation rate is carried out by measuring a frequency of an energy release in a certain amount of time when the energy accumulated in the capacitor reaches the certain level and is then released.Type: GrantFiled: July 26, 2012Date of Patent: February 4, 2014Assignees: Bioengineering Laboratories, LLC, Arkray, Inc., Ultizyme International Ltd.Inventors: Wakako Tsugawa, Koji Sode
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Publication number: 20140017331Abstract: The invention relates to new amphiphilic linear block copolymers of polysaccharides and polymers. The amphiphilic linear block copolymers do not form a true solution in water and are able to form micelles in selective solvents. Also disclosed are particles, each of which has a shell and a core, and a diameter of about 1 to 1,000 nanometers, and methods of delivering agents or removing substances, e.g., undesirable substances, from a subject or environment, by using these particles.Type: ApplicationFiled: September 12, 2013Publication date: January 16, 2014Inventors: Stephen J. McCarthy, Balint Koroskenyi, Robert J. Nicolosi
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Publication number: 20140017799Abstract: This invention relates to a sensing method and a sensing device for quantifying the concentration of an analyte by using the property that interaction between an analyte and a labeled compound changes fluorescence intensity. A fluorescence sensor is used to acquire fluorescence intensity at predetermined quantification time points. Then, the concentration of an analyte is quantified in accordance with a non-steady concentration quantification law comprising the relationship between the acquired fluorescence intensity and the time derivative quantity thereof.Type: ApplicationFiled: March 5, 2012Publication date: January 16, 2014Applicants: OLYMPUS CORPORATION, TERUMO KABUSHIKI KAISHAInventors: Toshio Fukai, Atsushi Matsumoto, Kazuya Matsumoto, Takuro Suyama