Hetero-n Patents (Class 436/96)
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Patent number: 8563253Abstract: The present invention relates to a method for diagnosing hemolytic anemia or a predisposition thereof. It also relates to a method of determining whether a compound is capable of inducing hemolytic anemia in a subject and to a method of identifying a drug for treating hemolytic anemia. Furthermore, the present invention relates to a data collection comprising characteristic values of metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing hemolytic anemia. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing hemolytic anemia in a subject.Type: GrantFiled: June 4, 2007Date of Patent: October 22, 2013Assignee: Metanomics GmbHInventors: Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine, Edgar Leibold, Bennard van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunha, Eric Fabian, Volker Strauss
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Publication number: 20130273586Abstract: The present invention relates to methods of diagnosing, monitoring, and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating candidate compounds for use in treating chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, refractory asthma, and other related diseases. Examples of such methods include determining if the candidate compound decreases the degradation of elastic fiber in a patient administered the candidate compound by measuring, using mass spectrometry employing an internal standard, a marker of elastic fiber degradation in a sample of a body fluid or a tissue of the patient. The invention provides that a decrease in the presence of the marker compared to a control validates that the candidate compound is effective to treat, prevent, or ameliorate the disease.Type: ApplicationFiled: March 15, 2013Publication date: October 17, 2013Inventors: Gerard M. TURINO, Shuren Ma, Yong Y. Lin, Seymour Leiberman
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Patent number: 8545885Abstract: The subject invention provides a pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide or the salt thereof; a pharmaceutically acceptable carrier; and not more than 0.5% w/w relative to N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide of 2-Chloro-6-(1-ethyl-N-methyl-2-oxoindoline-3-carboxamido)benzoic acid, 1H,3H-spiro[5-chloro-1-methylquinoline-2,4-dione-3,3?-[1]ethylindolin-[2]-one], or 5-Chloro-N-ethyl-3-hydroxy-1-methyl-2,4-dioxo-N-phenyl-1,2,3,4-tetrahydro-quinoline-3-carboxamide.Type: GrantFiled: May 14, 2012Date of Patent: October 1, 2013Assignees: Teva Pharmaceutical Industries, Ltd., Active Biotech, ABInventors: Muhammad Safadi, Daniella Licht, Ioana Lovinger, Aharon M. Eyal, Tomas Fristedt, Karl Jansson
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Patent number: 8541240Abstract: The present invention generally relates to fluoride receptor reagent compounds that are derived from one or more N-aryl or heteroaryl substituted 1,4,5,8-naphthalenetetracarboxydiimide (NDI) units. The invention also relates to associated methods for the detection of fluoride in a composition. ?-electron orbitals present in the NDI unit of the reagents form a complex with fluoride anions. It is believed that the anion-? interaction results in a charge transfer process between the fluoride anion and the NDI unit, resulting in a number of measurable effects (e.g., colorimetric response).Type: GrantFiled: May 31, 2011Date of Patent: September 24, 2013Assignee: Florida State University Research Foundation, Inc.Inventors: Sourav Saha, Samit Guha
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Patent number: 8541239Abstract: The invention provides an assay method for the detection of a primary amine analyze in an aqueous body fluid, which method comprises contacting a sample of said body fluid at a pH below 9.5 with a thiol and an unsaturated cis-dialdehyde and testing for the presence of a pyrrole reaction product.Type: GrantFiled: October 15, 2009Date of Patent: September 24, 2013Assignee: Oxtox LimitedInventors: Dimitrios Konstantinos Kampouris, Patrick Robinson Huddleston, Craig Edward Banks
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Patent number: 8535946Abstract: The response of a patient with an enteropathic disease to therapy, particularly a candidate therapy in a clinical trial setting, is assessed by detecting the ability of the patient to metabolize an orally administered CYP3A substrate. The CYP3A metabolism may be monitored in a variety of ways. Conveniently, the appearance of a metabolite of the CYP3A substrate is detected in a patient sample over a period of time following oral administration, e.g. in urine, plasma, breath, saliva, etc. The CYP3A substrate is optionally labeled, e.g. with an isotopic, fluorescent, etc. label.Type: GrantFiled: August 28, 2008Date of Patent: September 17, 2013Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Chaitan Khosla, Michael Bethune
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Patent number: 8481324Abstract: The present invention provides a system containing an array of chemically sensitive sensors based on coated single walled carbon nanotubes, for measuring volatile organic compounds indicative of renal failure. Methods of breath analysis for diagnosing chronic, acute and end-stage renal failure are disclosed.Type: GrantFiled: December 2, 2009Date of Patent: July 9, 2013Assignee: Technion Research and Development Foundation Ltd.Inventors: Hossam Haick, Zaid Abassi, Farid Nakhoul
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Patent number: 8455265Abstract: A surface grafted conjugated polyelectrolyte (CPE) is formed by coupling a CPE by a coupling moiety to the surface of a substrate. The substrate can be of any shape and size, and for many uses of the surface grafted CPE, it is advantageous that the substrate is a nanoparticle or microparticle. Surface grafted CPEs are presented that use silica particles as the substrate, where a modified silane coupling agent connects the surface to the CPE by a series of covalent bonds. Two methods of preparing the surface grafted CPEs are presented. One method involves the inclusion of the surface being modified by the coupling agent and condensed with monomers that form the CPE in a grafted state to the substrate. A second method involves the formation of a CPE with terminal groups that are complimentary to functionality that has been placed on the surface of the substrate by reaction with a coupling agent. The surface grafted CPEs are also described for use as biosensors and biocides.Type: GrantFiled: February 29, 2008Date of Patent: June 4, 2013Assignee: STC.UNMInventors: David G. Whitten, Sireesha Chemburu, Thomas Corbitt, Linnea Ista, Gabriel Lopez, Kirk S. Schanze, Motokatsu Ogawa, Eunkyung Ji
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Publication number: 20130130396Abstract: The present invention relates to assays for detection of nicotine metabolites, in particular cotinine, in fluid samples and uses of these assays in quantification of smoking habits. The assays comprise contacting a body fluid sample with a cyanogen halide and a pyrazolone compound and detecting a change in light absorbance of the pyrazolone compound which is associated with the presence of nicotine metabolites. Also provided are assay kits including a cyanogen halide or cyanogen halide-precursor(s) and a pyrazolone compound.Type: ApplicationFiled: May 13, 2011Publication date: May 23, 2013Inventors: Charles John Knill, John Frederick Kennedy
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Patent number: 8426213Abstract: The present invention relates to providing improved hydrogen peroxide assays, as well as droplet actuators for conducting such assays. The droplet actuators of the invention may be used to conduct droplet-based hydrogen peroxide assays. They may also be associated with detectors for analyzing the results of the hydrogen peroxide assays of the invention. They may be provided as components of systems which control droplet operations and/or detection for conducting the hydrogen peroxide assays. Measurement by the detector may be used to quantify the presence of an analyte in a sample.Type: GrantFiled: March 5, 2008Date of Patent: April 23, 2013Assignee: Advanced Liquid Logic IncInventors: Allen E. Eckhardt, Vijay Srinivasan, Vamsee K. Pamula
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Publication number: 20130071939Abstract: An analysis device includes determination means, capable of performing a first determination on whether a specific component in urine is positive or negative, on the basis of a color reaction between a reagent and the specific component in urine; and optical measurement means capable of working out data on light absorption characteristics of the urine itself with respect to light of a predefined wavelength region. When the data on the light absorption characteristics lies within a predefined range, and a result of the first determination is either positive or negative as established beforehand, the determination means changes the result of the first determination to a false positive or a false negative, or performs second determination to the effect that there is a likelihood of a false positive or a false negative.Type: ApplicationFiled: May 23, 2011Publication date: March 21, 2013Applicant: ARKRAY, INC.Inventors: Shinya Nakajima, Kosuke Kubo
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Publication number: 20130071940Abstract: Chemoselective derivatization of biological amines, carboxylic acids, aldehydes or ketones are employed in methods to detect a plurality of components, or members of a component, such as metabolites, that vary in molecular structure. The methods of the invention can be employed in aqueous and nonaqueous conditions.Type: ApplicationFiled: August 15, 2012Publication date: March 21, 2013Applicant: Brown UniversityInventors: Jason K. Sello, Kyle A. Totaro, Babajide O. Okandeji
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Patent number: 8394643Abstract: The present application relates to copolymers having at least one optionally substituted fluoranthene as a first monomer unit and at least one optionally substituted pyrrole as a second monomer unit. The copolymer may, for example, emit green light when exposed to a blue or ultraviolet radiation. Methods of making the copolymer are also disclosed, as well as methods and apparatuses for producing light and detecting nitroaromatics using the copolymer.Type: GrantFiled: March 3, 2011Date of Patent: March 12, 2013Assignee: Tongji UniversityInventors: Xingui Li, Dunyin Gu, Meirong Huang
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Patent number: 8389232Abstract: The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut.Type: GrantFiled: May 13, 2009Date of Patent: March 5, 2013Assignee: The Regents of the University of CaliforniaInventor: Rebecca Braslau
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Patent number: 8383064Abstract: A test module for performing a genetic diagnostic assay, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for a biological sample containing target nucleic acid sequences, an array of chambers containing probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, a flow-path extending from the inlet to the probes, and, a reagent reservoir containing a reagent for addition to the sample in the flow-path upstream of the probes, wherein, each of the chambers contains less than 270 picograms of probe and the reagent reservoir has a volume less than 1000,000,000 cubic microns.Type: GrantFiled: June 1, 2011Date of Patent: February 26, 2013Assignee: Silverbrook Research Pty LtdInventors: Mehdi Azimi, Kia Silverbrook
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Publication number: 20130045501Abstract: A detection device for detecting analytes in liquid specimen is provided. The detection device comprises: a specimen chamber for collecting or storing a liquid specimen; a detecting chamber for containing a detecting element; and a through hole for transferring the liquid specimen between the specimen chamber and the detecting chamber. The through hole can be opened or self-sealed. The sealing or opening of the through hole controls whether or not the liquid specimen in the specimen chamber enters the detecting chamber via the through hole. Furthermore, a detection method is provided.Type: ApplicationFiled: March 25, 2011Publication date: February 21, 2013Inventors: Lin Hu, Haipeng Hu, Yinfei Wu
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Publication number: 20130040392Abstract: Various agents for improving adhesion of cold end coatings on glass surfaces are described Also described are agents for improving bonding between cold end coatings and organic inks. And, methods and related detection solutions for detecting the presence of cold end coatings on a substrate such as a glass bottle are disclosed. Additionally, particular additives and primers are described that can be applied onto cold end coatings for improving adhesion thereto.Type: ApplicationFiled: January 21, 2011Publication date: February 14, 2013Applicant: FERRO CORPORATIONInventors: Cindy Pankiewicz, Thirumalai Duraisamy, Bertram Gardner, Ian Dudas, David C. Kapp, Enos A. Axtell, III, George E. Sakoske
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Publication number: 20130022549Abstract: The present invention relates to a composition and method for the detection of a detectable product formed from a compound of the present invention in the body of an individual. The detectable product may include a halide or a benzenetriol-based or benzenetetrol-based product of a dehalogenation reaction in the presence of FROS. In many embodiments, an indigo-like product formed from an indigogenic compound of the present invention may also be a detectable product for diagnostic purposes. This indigo-like product may have a higher residence time in tissues where it is formed, thus providing a detectable product localized to sites of high FROS. An indigogenic compound containing one or more radioactive isotopes is further provided for therapeutic purposes.Type: ApplicationFiled: July 13, 2012Publication date: January 24, 2013Inventor: Keith R. Latham
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Publication number: 20130017616Abstract: The present invention provides methods for treating or limiting development of inflammatory disorders.Type: ApplicationFiled: July 13, 2012Publication date: January 17, 2013Applicant: Vanderbilt University - Center for Technology Transfer and CommercializationInventor: Billy G. Hudson
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Publication number: 20130011929Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.Type: ApplicationFiled: July 11, 2012Publication date: January 10, 2013Applicant: WyethInventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
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Publication number: 20130004940Abstract: A device for detecting an analyte in a sample is provided, which comprises: a collecting chamber containing an opening for collecting a liquid sample; a detecting element for detecting an analyte in the liquid sample; and a lid for covering the opening of the collecting chamber. The device further comprises an indicating device thereon to indicate whether or not the lid covers at an appointed position. The operation of the device is very simple.Type: ApplicationFiled: November 23, 2010Publication date: January 3, 2013Inventors: Haipeng Hu, Jianfeng Wang
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Publication number: 20120296145Abstract: Methods for monitoring ionic liquids using vibrational spectroscopy may involve contacting an infrared (IR) transmissive medium with the ionic liquid, recording an IR spectrum of the ionic liquid, and quantifying at least one chemical characteristic of the ionic liquid based on the IR spectrum. The IR spectrum may be recorded ex situ or in situ. Methods for controlling ionic liquid catalyzed processes are also disclosed, wherein a condition of the ionic liquid may be determined during such processes based on IR spectral analysis of the ionic liquid.Type: ApplicationFiled: May 16, 2011Publication date: November 22, 2012Applicant: CHEVRON U.S.A INC.Inventor: Howard Steven Lacheen
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Publication number: 20120295363Abstract: What is provided includes a porous sol-gel material whose intrinsic pH is lower than 1 and comprising at least one probe molecule chosen from the group consisting of croconic acid, p-dimethyl-aminobenzaldehyde (DMABA), p-dimethyl aminocinnamaldehyde (DMACA), p-methoxybenzaldehyde (MOB) and 4-methoxy-1-naphtaldehyde (MON). In addition, a detection system containing the porous sol-gel material and a method of preparation and use of the porous sol-gel material for trapping and/or detecting and optionally quantifying at least one chemical compound such as indole and indole compounds are provided.Type: ApplicationFiled: November 10, 2010Publication date: November 22, 2012Applicants: Centre National de la Recherche Scientifique, COMMISSARIAT a I'energie atomique et aux energies alternativesInventors: Sabine Crunaire, Thu-Hoa Tran-Thi
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Patent number: 8309359Abstract: Isobaric reagents for labeling analytes are provided. The isobaric reagents have facile design and synthesis that allows for differential labeling of an unlimited number of analyte samples.Type: GrantFiled: January 14, 2011Date of Patent: November 13, 2012Assignee: California Institute of TechnologyInventors: Chang Ho Sohn, Jesse L. Beauchamp
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Publication number: 20120258886Abstract: The invention is directed towards novel amino acid based compounds, which may be isotopically enriched, and methods of use of such compounds for characterising one or more molecules of a sample by mass spectrometry, the method comprising: (a) reacting the one or more molecules with the compound; and (b) characterising the one or more molecules by mass spectrometry.Type: ApplicationFiled: October 14, 2010Publication date: October 11, 2012Applicant: DANA-FARBER CANCER INSTITUTE, INC.Inventors: Jarrod A. Marto, Scott B. Ficarro, Manor Askenazi
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Publication number: 20120225124Abstract: The subject invention provides a pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide or the salt thereof; a pharmaceutically acceptable carrier; and not more than 0.5% w/w relative to N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide of 2-Chloro-6-(1-ethyl-N-methyl-2-oxoindoline-3-carboxamido)benzoic acid, 1H,3H-spiro[5-chloro-1-methylquinoline-2,4-dione-3,3?-[1]ethylindolin-[2]-one], or 5-Chloro-N-ethyl-3-hydroxy-1-methyl-2,4-dioxo-N-phenyl-1,2,3,4-tetrahydro-quinoline-3-carboxamide.Type: ApplicationFiled: May 14, 2012Publication date: September 6, 2012Inventors: Muhammad Safadi, Daniella Licht, Ioana Lovinger, Aharon M. Eyal, Tomas Fristedt, Karl Jansson
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Patent number: 8257666Abstract: The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e. Polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene.Type: GrantFiled: February 8, 2012Date of Patent: September 4, 2012Assignee: California Institute of TechnologyInventors: Stephen R. Quake, Hou-Pu Chou
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Publication number: 20120220039Abstract: A method and system for detecting residual poison in human body are provided. Using the disclosed HPLC-Chip-mass spectrometry (MS)/MS and/or HPLC-MS/MS method to detect the residual poison, the method of the present invention mainly includes sample preparation, liquid chromatography and mass spectrometry. The method of the present invention has advantages of low sample size, high specificity, low detection limit, high sensitivity, low cost, high accuracy and stability, etc.Type: ApplicationFiled: November 5, 2010Publication date: August 30, 2012Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Karl Wah Keung Tsim, Tina Tingxia Dong, Kevin Yue Zhu, Ka Wing Leung, Tiejie Wang
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Publication number: 20120196300Abstract: The present invention relates to methods for detecting a psychiatric condition optionally associated with a depression comprising the steps of measuring the concentration of at least one in vivo degradation product of tryptophan. Further, the present invention relates to the use of said values as predictive markers for the detection of a psychiatric condition optionally associated with a depression and a kit containing means for detecting said values.Type: ApplicationFiled: February 21, 2012Publication date: August 2, 2012Applicants: DIAMED-EUROGEN N.V., Klinik und Poliklinik fur Psychiatrie und Psychotherapie, UNIVERSITY OF ANTWERP, UNIVERSITY OF MAASTRICHTInventors: Aye Mu Myint, Manfred Schawaller, Robert Verkerk, Markus J. Schwarz, Harald Hampel, Norbert Müller
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Patent number: 8231833Abstract: A whispering gallery mode resonator based optical sensor assembly comprises a flow channel permeable to optical energy and first and second optical waveguides adjacent to a section of the flow channel and adapted to be in first and second evanescent field couplings respectively with the section such that the section forms a whispering gallery mode resonator. The resonator is responsive to an optical signal conveyed in the first optical waveguide and communicates a second optical signal to the second optical waveguide indicative of a resonance wavelength of the whispering gallery mode resonator. A detector optically coupled to the second optical waveguide detects the output signal. A signal processor detects a shift in the output signal responsive to an analyte fluid flowing through the flow channel. The shift is indicative of the identity of at least one constituent of the analyte fluid.Type: GrantFiled: March 17, 2010Date of Patent: July 31, 2012Assignee: Lockheed Martin CorporationInventors: Scott Maurer, Stephanie Groves, Kee Koo
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Publication number: 20120157454Abstract: There are provided substituted isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds. A screening method for the identification of compounds capable of binding several PARP proteins, as well the probes used in such method, are further objects of the invention.Type: ApplicationFiled: May 19, 2010Publication date: June 21, 2012Applicant: NERVIANO MEDICAL SCIENCES S.R.L.Inventors: Gianluca Mariano Enrico Papeo, Jay Aaron Bertrand, Giovanni Cervi, Barbara Forte, Rosita Lupi, Alessia Montagnoli, Alessandra Scolaro, Fabio Zuccotto, Paolo Orsini, Helena Posteri
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Patent number: 8198096Abstract: The present invention relates to a class of luminescent and conductive polymer compositions having chromophores, and particularly solid films of these compositions exhibiting increased luminescent lifetimes, quantum yields and amplified emissions. These desirable properties can be provided through polymers having rigid groups designed to prevent polymer reorganization, aggregation or ?-stacking upon solidification. These polymers can also display an unusually high stability with respect to solvent and heat exposures. The invention also relates to a sensor and a method for sensing an analyte through the luminescent and conductive properties of these polymers. Analytes can be sensed by activation of a chromophore at a polymer surface. Analytes include aromatics such as heterocycles, phosphate ester groups and in particular explosives and chemical warfare agents in a gaseous state.Type: GrantFiled: September 29, 2006Date of Patent: June 12, 2012Assignee: Massachusetts Institute of TechnologyInventors: Timothy M. Swager, John P. Amara
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Patent number: 8178127Abstract: The subject invention provides a pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide or the salt thereof; a pharmaceutically acceptable carrier; and not more than 0.5% w/w relative to N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide of 2-Chloro-6-(1-ethyl-N-methyl-2-oxoindoline-3-carboxamido)benzoic acid, 1H,3H-spiro[5-chloro-1-methylquinoline-2,4-dione-3,3?-[1]ethylindolin-[2]-one], or 5-Chloro-N-ethyl-3-hydroxy-1-methyl-2,4-dioxo-N-phenyl-1,2,3,4-tetrahydro-quinoline-3-carboxamide.Type: GrantFiled: December 19, 2008Date of Patent: May 15, 2012Assignee: Teva Pharmaceuticals Industries, Ltd.Inventors: Muhammad Safadi, Daniella Licht, Ioana Lovinger, Aharon M. Eyal, Tomas Fristedt, Karl Jansson
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Patent number: 8178357Abstract: Sensors, sensing systems and sensing methods of the invention provide for detection of peroxides, including for example, vapor-phase H2O2 and organic peroxides such as di-tert-butyl peroxide. A sensor and sensing method of the invention uses at least two phthalocyanines, one of which exhibits an oxidation reaction with peroxides and the other of which exhibits a reduction reaction with peroxides. A peroxide is readily identified by a sensor of the invention when one of the at least two phthalocyanines exhibits increased resistance to current flow and the other of the at least two phthalocyanines exhibits decreased resistance to current flow.Type: GrantFiled: July 23, 2008Date of Patent: May 15, 2012Assignee: The Regents of the University of CaliforniaInventors: William C. Trogler, Forest Bohrer, Andrew C. Kummel
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Patent number: 8148160Abstract: Molecular sensing of target molecules is performed by using an electrode for molecular sensing in which detecting molecules which can shift a surface potential of the electrode by an interaction with the target molecules are bound directly or via coupling molecules to surface hydroxyl groups on a conductive metal oxide. By this molecular sensing, specific target molecules can be detected selectively and stably with high accuracy. It is also possible to detect an enantiomer selectively and stably with high accuracy. The present invention can provide a chemical sensing system which is useful in fields such as medicines, environments and foods.Type: GrantFiled: December 4, 2008Date of Patent: April 3, 2012Assignee: Waseda UniversityInventors: Tetsuya Osaka, Mariko Matsunaga, Tsubasa Ueno
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Publication number: 20120045840Abstract: Applicants have produced a chromophore and a polymer that are highly sensitive to the presence of various agents, including organophosphates, pesticides, neurotoxins, metal ions, some explosives, and biological toxins. The detection is accomplished by detecting a change in the fluorescence characteristics of the chromophore or polymer when in the presence of the agent to be detected. The chromophore and polymer may be incorporated into sensors of various types, and they are adaptable for potential field use in areas where detection of these types of agents is desired.Type: ApplicationFiled: February 7, 2011Publication date: February 23, 2012Applicant: NDSU-RESEARCH FOUNDATIONInventors: Johnson Thomas, Philip Boudjouk
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Publication number: 20110312100Abstract: The invention provides an assay method for the detection of a primary amine analyte in an aqueous body fluid, which method comprises contacting a sample of said body fluid at a pH below 9.5 with a thiol and an unsaturated cis-dialdehyde and testing for the presence of a pyrrole reaction product.Type: ApplicationFiled: October 15, 2009Publication date: December 22, 2011Applicant: OXTOX LIMITEDInventors: Dimitrios Konstantinos Kampouris, Patrick Robinson Huddleston, Craig Edward Banks
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Publication number: 20110300567Abstract: A method for identifying the redox activity of a subject compound is disclosed. The method can be performed aerobically and can include forming a mixture comprising a free-radical precursor and a compound to be tested, and converting the free-radical precursor into a free-radical anion and a free-radical cation. After the free radical cation and the free radical anion have been formed, the relative redox activity of the subject compound may cause a difference in the rate of photo-bleaching of the mixture and/or the rate of superoxide generation. These differences can be quantified and used to identify the redox activity of the subject compound. This sensitive technique for measuring redox activity can be used to screen compounds for various biological applications. Drugs also can be developed based on the relationship between redox activity and biological activity for particular biological applications.Type: ApplicationFiled: August 9, 2011Publication date: December 8, 2011Inventors: Jonathan J. Abramson, Benjamin S. Marinov
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Patent number: 8071388Abstract: The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes.Type: GrantFiled: February 24, 2009Date of Patent: December 6, 2011Assignee: Ensemble Therapeutics CorporationInventors: Yumei Huang, James M. Coull
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Publication number: 20110275558Abstract: The present invention relates to the field of medical treatments for diseases and disorders. More specifically, the present invention relates to the use of the lanthionine synthetase component C-like (LANCL) proteins as therapeutic targets for novel classes of anti-inflammatory, immune regulatory and antidiabetic drugs.Type: ApplicationFiled: May 4, 2011Publication date: November 10, 2011Applicant: Virginia Tech Intellectual Properties, Inc.Inventors: Josep BASSAGANYA-RIERA, Pinyi LU, Raquel HONTECILLAS
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Publication number: 20110263029Abstract: The present invention is directed to methods and kits for the determining the presence or absence of ergot alkaloids in sample which use chromatographic instrumentation and columns operating at a pressure of 4,000 to 15,000 psi and columns with 1-3 micron particle size to produce results by mass spectroscopy in approximately four minutes.Type: ApplicationFiled: October 16, 2009Publication date: October 27, 2011Applicant: WATERS TECHNOLOGIES CORPORATIONInventor: Stuart A. Oehrle
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Publication number: 20110244584Abstract: The present invention provides a system comprising an array of chemically sensitive sensors based on coated single walled carbon nanotubes, for measuring volatile organic compounds indicative of renal failure. Methods of breath analysis for diagnosing chronic, acute and end-stage renal failure are disclosed.Type: ApplicationFiled: December 2, 2009Publication date: October 6, 2011Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.Inventors: Hossam Haick, Zaid Abassi, Farid Nakhoul
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Publication number: 20110236982Abstract: Embodiments of this invention relate to the analysis of mass spectral data in the quiet zones.Type: ApplicationFiled: December 14, 2010Publication date: September 29, 2011Applicant: DH Technologies Development PTE, LTD.Inventor: Darryl J.C. Pappin
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Patent number: 8026110Abstract: The present invention relates to a rosamine derivative compound, as described herein, having the following structure: Also disclosed are methods of making such compounds and for using them for detection and imaging.Type: GrantFiled: September 11, 2007Date of Patent: September 27, 2011Assignee: New York UniversityInventors: Young-Tae Chang, Young-Hoon Ahn
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Patent number: 8017403Abstract: Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5?-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.Type: GrantFiled: June 14, 2007Date of Patent: September 13, 2011Assignee: Quest Diagnostics Investments IncorporatedInventors: Qibo Jiang, Sum Chan, Richard Reitz
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Publication number: 20110217720Abstract: This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.Type: ApplicationFiled: March 14, 2011Publication date: September 8, 2011Inventors: Darryl J.C. Pappin, Michael Bartlet-Jones
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Publication number: 20110171677Abstract: The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut.Type: ApplicationFiled: May 13, 2009Publication date: July 14, 2011Inventor: Rebecca Braslau
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Patent number: 7977110Abstract: A method for distinguishing between kidney dysfunctions in a mammal, including pre-renal azotemia, an acute renal injury that may progress to acute renal failure, and chronic kidney disease, using a urinary or circulating NGAL assay result that is compared to a predetermined NGAL cutoff level, and a single serum or plasma creatinine measurement. Typically the single creatinine measurement cannot distinguish acute renal injury from chronic kidney disease or pre-renal azotemia, a single measurement of urinary NGAL, combined with the single serum or plasma creatinine measurement, has sufficient sensitivity and specificity to distinguish acute renal injury from normal function, prerenal azotemia, and chronic kidney disease and predicts poor inpatient outcomes.Type: GrantFiled: June 21, 2008Date of Patent: July 12, 2011Assignees: Children's Hospital Medical Center, The Trustees of Columbia UniversityInventors: Jonathan Matthew Barasch, Prasad Devarajan, Thomas L. Nickolas
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Publication number: 20110135575Abstract: The present invention generally relates to Magnetic Resonance Imaging (MRI) analysis of the location, presence, and/or quantity of a particular molecule or material. In some embodiments, the invention relates to compositions and methods for determination of an analyte, wherein a compositions may produce an MRI signal that can be affected by the presence of a particular composition (e.g., analyte). In a particular embodiment, the composition comprises a protein. The invention also provides related nucleic acid molecules, polypeptides, and fragments thereof. Compositions of the invention may exhibit reduced toxicity and may be readily delivered in vivo. Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like.Type: ApplicationFiled: August 28, 2008Publication date: June 9, 2011Applicant: Massachusetts Institute of TechnologyInventors: Mikhail G. Shapiro, Philip Romero, Robert S. Langer, Frances Arnold, Alan Preadip Jasanoff
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Patent number: 7947511Abstract: Ultrasensitive detection of a chemical substance (analyte) by mass spectrometry is achieved by employing a molecular tag that yields an intense parent ion and then an intense daughter ion in a multi-stage mass spectrometer.Type: GrantFiled: June 5, 2009Date of Patent: May 24, 2011Assignee: Northeastern UniversityInventors: Poguang Wang, Guodong Li, Jianxin Gao, Roger W. Giese, Xin Zhang