Abstract: The present invention provides a pharmaceutical composition for treating cancer, comprising at least one selected from deoxyribonucleic acids (DNA) for encoding small interfering RNA (siRNA) which complementarily binds to the base sequence of the transcript (mRNA transcript) of the FLJ25416 gene, represented by sequence number 3, sequence number 5, and sequence number 7 to inhibit the intracellular expression of the FLJ25416 gene, antisense RNA which inhibits expression of the FLJ25416 gene, and short hairpin RNA (shRNA) which inhibits expression of the FLJ25416 gene. As the siRNA, which is complementary to the base sequence of the transcript (mRNA transcript) of the FLJ25416 gene, the antisense RNA, and the shRNA, according to the present invention, inhibit expression of the FLJ25416 gene which is known to be expressed in cancer cells, and thus kill cancer cells, the composition of the present invention can be used as a novel anti-cancer agent.

Abstract: A coin processing device includes a rotating member that has an annular rib provided annularly along a circumferential direction on the outer peripheral portion, which transports a coin upon a transport path using a cutout portion formed upon a lower portion of the annular rib. An open position intersects the annular rib. An opening and closing member, when positioned at the open position, is positioned adjacent to the annular rib in a radial direction of the rotating member so as to allow rotation of the rotating member.

Abstract: A method for exchanging coins, the method including the acts of receiving in a self-service coin exchange machine a plurality of coins, processing the plurality of coins to determine a total value of the plurality of coins, and dispensing currency to the patron from a currency dispenser, the currency having a value related to the total value.

Abstract: Replenishing coins in a coin store associated with a coin handling device includes feeding a batch of coins from a bulk coin store to a receptacle near the coin handling device, delivering coins from the receptacle to the coin handling device and routing at least some of those coins from the coin handling device to the coin store associated with the coin handling device.

Abstract: A device for singularising coins of different sizes and thickness with a housing which comprises an obliquely inclined base plate is suggested. A catch element for catching and conveying coins to a further processing is rotatably arranged above the base plate. The coins are randomly present at least in the lower region of the base plate on which a collection container is fastened. A flap is arranged in the base plate, which opens and closes synchronously with the driven coin catch element for leading a caught coin further.

Abstract: A coin-separating and feeding device receives coins of different dimensions, sorts them in a sorting recess positioned on a rotating disk. A moving member is positioned within a sorting recess groove and reciprocates linearly between a sorting position for receiving a coin and a pushing-out position to feed for subsequent processing. The bulk coins are stored in a container that houses the rotating disk and an arc-shaped restrictor can surround an outer periphery of at least a portion of the rotating disk to maintain the separated coin within the sorting recess. A driving device comprising a ring shaped cam is fixedly arranged relative to the rotating disk and a pair of can followers mounted on the moving member can control the speed of the mover member including accelerating and decelerating the speed from a push-out position to a coin receiving position within the sorting recess.

Abstract: In a coin feeding machine 26 which uses a rotary disk 41 rotated at an inclined posture, a removal projection 59 for removing a smaller diameter coin is provided between a feeding projection 52 and a coin support portion 53 which are provided on a surface 41a of the rotary disk 41. The removal projection 59 is disposed to be positioned on the slightly outer side of the outer edge of a coin C when the coin C whose diameter is a lower limit value of a handling target range is brought into contact with the feeding projection 52 and the coin support portion 53. The side surface of the removal projection 59 is inclined relative to the surface of the rotary disk 41. When the coin is brought onto the inclined surface of this removal projection 59, the coin drops away from the surface 41a of the rotary disk 41. A coin C1 which is smaller than the lower limit value of the handling target range is brought onto the removal projection 59, so as to be dropped from the surface 41a of the rotary disk 41 and removed.

Abstract: A mechanism for separating single coins from a plurality of coins provided within a coin dispensing apparatus. The mechanism comprises a housing defining a coin dispensing path, coin transport means for urging coins along the coin dispensing path; and first and second biased coin stripping members located adjacent each other and disposed successively in the coin dispensing path at an outlet of the coin dispensing mechanism. The first and second stripping members together comprise a double outlet gate and each member is movable independently of the other by each urged coin to effect, in use, alignment and stripping of coins being dispensed.

Abstract: According to one embodiment of the present disclosure, a coin processing system includes a coin input area that receives coins from a user, a coin processing module that counts the received coins, and a foreign object detection system that detects a foreign object within the coin processing module subsequent to counting substantially all the received coins.

Abstract: A coin sorting plate for receiving and sorting a stream of coins by the diameter and hence the denomination of the coin has a number of coin recesses that extend along the path of the coin stream. Each coin recess is sized to receive a respective coin diameter. The coin recesses are arranged with the recess openings increasing in size in the downstream direction to progressively remove coins in order of increasing diameter. Each coin recess is bounded by a downstream wall that forces a coin in the recess to move off a peripheral edge of the coin sorting plate for collection or other processing.

Abstract: An elastic coin moving disk assembly (23) for moving coins across a coin sorting and coin collection member (13) in a coin handling machine (10), in which the coin sorting and coin collection member (13) has openings (28) of varying size to receive coins (14) of respective denominations, the coin moving disk assembly (23) having an annular disk body with a groove (32) and an outer rim (35) having a cavity (33) in a bottom surface; and a fin ring (39) molded into the cavity (33) in the bottom surface, the fin ring (39) comprising planar fingers (42) extending downward and substantially perpendicular to the bottom surface of the rim (35) when first manufactured, and later taking on an angular “set” after an initial break-in period, which is compensated for by a user-removable shim (43).

Abstract: A self-service change redemption machine (10) has an intake area (18) for receiving batches of mixed coinage and conveying the coins to a coin sorter (22) for sorting, counting and directing coins into a plurality of coin chutes (26). From there, the coins are routed to coin receptacles such as bags (60). Multiple bags are provided for certain denominations. To fill multiple bags for a given denomination, repositionable diverter mechanisms (30) are provided between the chutes (26) and pluralities of bags for the respective denominations. The bags are held by bag holders (34) which extend downward from a substantially rigid one-piece chassis (40), which also supports the diverter mechanisms (30). The machine (10) has buttons (80) responsive to inputs from a user to turn on the machine, to process coins that are input through the intake area (18) and to issue the voucher or other form of credit. Instructions for using the machine (10) and other information are displayed on a screen display (15).

Abstract: The coin sorting system includes a feed unit, a sorting unit, and a passageway member. Each unit has a rotary disc and a stationary member opposed to the disc. Each disc has a rotating axis inclined relative to a horizontal plane. A guide passageway with an outlet thorough which coins are fed one by one as the disc rotates is formed on the stationary member of the feed unit. Provided on the stationary member of the sorting unit are a conveying passageway with an inlet thorough which the coins fed from the outlet are introduced one by one and multiple sorting devices each for selectively ejecting the coins. A rolling-coin passageway is formed on the passageway member extending aslope to cause the coins to roll from the outlet to the inlet under own weight thereof.

Abstract: A coin processing machine includes a first stationary finger and a second stationary finger spaced from the first stationary finger and defining a first opening between them to receive a stream of singulated coins. The first opening is larger than the largest diameter coin to be processed by the coin processing machine. A movable third finger is spaced from the first finger and defines a second opening downstream from the first opening. Larger-diameter coins move the third finger to permit the coins to move through the second opening and past the third finger. Smaller-diameter coins that pass through the first opening and engage the third finger are directed towards the first finger before reaching and passing through the second opening.

Abstract: A cash recycling machine (10) has an input hopper (19) for feeding batches of mixed coinage to a coin sorter (21) for sorting, counting and directing coins into a plurality of bulk coin storage receptacles (31, 32, 33, 34). From there, the coins are fed into a plurality of smaller dispensing hoppers (46, 47, 48, 49) equipped with sensors (88) for counting the coinage as it is dispensed. A controller (80) is responsive to inputs from a user in a first operating cycle of the machine to cause the dispensing hoppers (46, 47, 48, 49) to dispense an amount of sorted coinage into one of several receptacles including a cash drawer (15) or coin bags (40). A controller (80) is responsive to inputs from a user in a second operating cycle of the machine to receive, sort and count a batch of coins that is loaded into the input hopper (19) and stored in the bulk coin storage receptacles (31, 32, 33, 34).

Abstract: Chip sorting devices include a rotatable disc having a plurality of wells for receiving chips therein, a plurality of channels for holding stacks of chips, at least one ejector for ejecting chips from the wells of the disc into the channels, and at least one removal lever associated with at least one of the channels. The removal lever has an arm configured to extend adjacent at least a portion of a stack of chips when the stack of chips is in a channel. Other chip sorting devices include a plurality of wells for receiving chips therein, a plurality of channels for holding stacks of chips, at least one ejector for ejecting chips from the wells of the disc into the channels, and at least one spring member configured to bias the ejector to a position.

Abstract: A coin or token image acquiring apparatus includes a coin moving unit for receiving coins in a sequential manner and translating each coin to a predetermined station. A time sensor unit detects the position of the respective coins in the coin moving unit and provides a timing signal that can activate an image apparatus unit positioned at the predetermined station. A light emitting apparatus is positioned to illuminate the coin face at the predetermined station so that the image apparatus can capture an illuminated image of the face of the coin. A storage unit can store a reference image of an authenticated coin image where by a comparator unit can compare the captured image of the coin with the authenticated coin image to provide an authenticated output signal when the respective image is matched. A separator unit can separate false coins from authenticated coins.

Abstract: A hopper for a coin processing machine has a turntable that receives coins and rotates in a first direction to discharge coins from the hopper. A circumferential wall surrounds the turntable, and includes a coin discharge opening and a second opening. A diverter plate extends away from the wall upstream of the second opening. The diverter plate blocks coins from entering the second opening when the turntable rotates in the first direction. The diverter plate directs any debris remaining on the turntable to the second opening when the turntable rotates in the opposite, second direction after discharging all the coins from the hopper.

Abstract: A coin processing machine includes a first stationary finger and a second stationary finger spaced from the first stationary finger and defining a first opening between them to receive a stream of singulated coins. The first opening is larger than the largest diameter coin to be processed by the coin processing machine. A movable third finger is spaced from the first finger and defines a second opening downstream from the first opening. Larger-diameter coins move the third finger to permit the coins to move through the second opening and past the third finger. Smaller-diameter coins that pass through the first opening and engage the third finger are directed towards the first finger before reaching and passing through the second opening.

Abstract: A coin sorting apparatus is provided. The coin sorting apparatus includes a coin separating unit for separating coins depending on kinds of the coins, and a coin receiving unit. The coin receiving unit continues to automatically operate until a plurality of coin receiving tubs are all full. Therefore, the number of coins that can be separated by one-time operation is increased, thereby improving a user's convenience.

Abstract: The invention relates to dopamine neuron determinants, the use of these determinants in differentiating cells to dopamine neurons, cells produced by the over-expression of these determinants, and uses of these cells.

Abstract: The present invention relates to methods and compositions utilizing inteins to generate libraries of cyclic peptides in vivo. The prevent invention also relates to methods for inhibiting protein-protein interaction.

Abstract: A coin recycling machine (10) for receiving, sorting and dispensing coins, comprising a coin dispenser having a rotatable coin magazine (23) for holding respective denominations of coins and having an electronic control (100, 107), said electronic control (100, 107) being operable in response to a commanded total to control position of said coin magazine (23) to selectively dispense coins to provide the commanded total, a queuing device (52) for receiving the coins and arranging the coins in a queue, the queuing device (52) having an exit (66) directed towards said coin magazine (23) and having associated sensors (65, 72) for identifying a denomination of a next coin to pass through the exit (66) and the electronic control being responsive to the sensors (65, 72) associated with the queuing device for positioning the coin magazine such that coins are sorted into the coin magazine (23) by denomination as the coins exit the queuing device (52).

Abstract: A miniaturized coin hopper device is provided so as to have a lower height. The device has an electric motor which is arranged such that the projection end of a rotated axis thereof is located at a lower side. A first gear is fixed on this projection end of rotated axis. A disk for discharging coins one by one is provided at the bottom of a hopper which stores the coins. A second gear rotates this disk. A gear train connects this second gear and the first gear. The problem of a true coin being disbursed when a pseudo-coin was stored in a hopper device and the return button was pushed is also addressed. A distinguishing element checks the money kind of a deposited coin. A reserve temporarily holds the coin distinguished by this distinction element. A storage for coins of same money kind and a disbursing element is provided for the the coin in this storage to return the coin reserved in the temporary reservation.

Abstract: A device for sorting discs or disk-like members of different identities (e.g. roulette chips) ejects the disks from a receptacle by means of a rotating wheel with numerous wells—(multi-chip storage compartments). Ejection of an article from the wells is achieved by an ejector lever making contact with an activated solenoid thus forcing the article at the bottom of the well, in conjunction with the momentum of the moving wheel, into a receiving space. The discs in the receiving spaces are continually replaced by newly-arriving discs which force the previously-positioned discs upwards into a column.

Abstract: A process for acceptance of coins in automatic payment transactions is provided, including leading, coins to at least one pair of rollers for the separation of the coins. A device for acceptance of coins in automatic payment transactions is also provided, including a pair of rollers where each rollers where each roller is rotated in the same direction and means of transportation through which the coins are supplied to the pair of rollers.

Abstract: A reduced-size coin sorter for sorting coins of mixed diameters is set forth. The sorter includes a coin-driving member and a coin-guiding member. The lower surface of the coin-guiding member forms a plurality of exit channels for guiding coins of different diameters to different exit stations along the periphery of the coin-guiding member. The coin sorter includes an integral base member which concentrically and circumferentially mounts both the rotatable disc and the sorting head. The unitary base member also provides as the mounting structure for the electronics and the motor.

Abstract: A coin bank (A) having one or more coin holders (70A-70D) removably aligned with one or more coin chutes (56A-56D) for receiving coins therefrom. The coin bank (A) preferably includes a coin sorter assembly (32) for sorting coins by diameter, a separator assembly (30) for conveying coins one at a time to the coin sorter assembly (32), a coin chute assembly (54) including the one or more coin chutes (56A-56D) each accommodating coins of a respective maximum diameter. The one or more coin chutes (56A-56D) each include at least one finger for abutting the top edge of the corresponding coin holder (70A-70D) for maintaining the alignment. An overflow passage (62) is defined in the wall of at least one of the coin chutes (56A-56D) for allowing coins to pass therethrough when the associated coin holder (70A-70D) is filled with coins.

Abstract: A coin sorting and counting machine and a method for operating it to automatically dispense cash vouchers based on the value of the counted coins, manufacturers' coupons and store coupons. Coins are placed in a hopper tray angled downward from the horizontal. When the hinged tray is lifted, the coins travel over a peak structure, through a waste management system and into the coin sorting and counting apparatus. The value of the coins and the number of coins within each denomination are displayed as the coins are counted. The coins fall into a storage area and the user is issued a cash voucher and a series of manufacturer coupons.

Abstract: A coin hopper is provided with a disk for dispensing petals-shaped coins smoothly. Particularly the discharging of coins for 20 Euro cents occurs with a smooth pay out using the disk in rotation, accepting a plurality of coins which are stored in a bulk condition. The disk has an opening for accepting and for releasing these coins one by one. The disk has a primary protrusion (23) which is formed on an underside of this disk (21), near the axis line of rotation and at a trailing side edge of the opening (22). A curved second protrusion (24) is formed near this primary protrusion and formed from the trailing side edge of said opening toward a further trailing position. A large curved third protrusion is formed from near trailing position of this second protrusion along the fringe area of the disk.

Abstract: A coin sorting apparatus receives coins through an opening in a guide plate onto the resilient surface of a rotating disc. The surface of the guide plate is contoured and includes portions positioned sufficiently close to the surface of the disc to press coins traveling therebetween into the resilient surface of the disc. As the coins are circulated circumferentially between the discs, the countours in the guide plate guide the coin into a single file along a first prescribed path. Coins of at least one selected denomination are displaced to follow a second prescribed path. The coins are discharged along each described path at exit locations at the periphery of the plate.

Abstract: A coin sorting apparatus receives coins through an opening in a guide plate onto the resilient surface of a rotating disc. The surface of the guide plate is contoured and includes portions positioned sufficiently close to the surface of the disc to press coins traveling therebetween into the resilient surface of the disc. As the coins are circulated circumferentially between the discs, the contours in the guide plate guide the coins into a single file along a first prescribed path. Coins of at least one selected denomination are displaced to follow a second prescribed path. The coins are discharged along each prescribed path at exit locations at the periphery of the plate.

Abstract: A coin sorting apparatus for receiving and sorting mixed coins by denomination, the apparatus having a rotatable disc having a resilient surface for receiving the coins and imparting rotational movement to the coins, and a stationary sorting head having a contoured surface spaced slightly away from and generally parallel to the resilient surface of the rotatable disc. The stationary sorting head includes a recess for guiding the coins on the rotatable disc into a single file of coins, a referencing wall for guiding one edge of the coins in the single file along a prescribed path, and a first exit channel for receiving the largest-diameter coins from the end of the referencing wall and guiding those coins to a first exit station on the periphery of the sorting head. A bypass guide wall intercepts all the other coins from the end of the referencing wall and guides the intercepted coins inwardly around the first exit channel.

Abstract: A coin sorting apparatus receives coins through an opening in a guide plate onto the resilient surface of a rotating disc. The surface of the guide plate is contoured and includes portions positioned sufficiently close to the surface of the disc to press coins traveling therebetween into the resilient surface of the disc. As the coins are circulated circumferentially between the discs, the contours in the guide plate guide the coins into a single file along a first prescribed path. Coins of at least one selected denomination are displaced to follow a second prescribed path. The coins are discharged along each prescribed path at exit locations at the periphery of the plate.

Abstract: A disc-type coin sorter has a rotatable disc with a resilient top surface and a stationary sorting head positioned above the disc with the lowermost surface of the sorting head only slightly spaced from the resilient top surface of the disc. The sorting head has coin queuing device for arranging coins of mixed denominations in a single row and a single layer with selected edges of the coins aligned at a common radial position. A first guide surface engages selected edges of the aligned coins and progressively moves the engaged coins radially as the coins move circumferentially along the first guide surface. A plurality of elongated second guide surfaces spaced radially from, and facing toward, the first guide surface force coins of selected denominations past the first guide surface at selected circumferential locations. Each of the elongated second guide surfaces has a substantially constant radius from the axis of rotation of the disc so that the coins engaged thereby are not moved radially.

Abstract: A coin sorter in which a sorting head is positioned over a rotating pliable disc and wherein coins are sorted by the combination of an inwardly or outwardly extending tapered edge and a series of pins generally positioned in an outwardly extending line spaced from the tapered edge. The spacing between the line of pins and tapered edge changes with radial dimension, whereby coins of different diameter are urged over the tapered edge by pins at different positions. The coins are then captured between the head and pliable disc and rotated to exit positions which are unique for each coin about the outside of the sorting head.

Abstract: A coin sorting apparatus receives coins through an opening in a guide plate onto the resilient surface of a rotating disc. The surface of the guide plate is contoured and includes portions positioned sufficiently close to the surface of the disc to press coins traveling therebetween into the resilient surface of the disc. As the coins are circulated circumferentially between the discs, the contours in the guide plate guide the coins into a single file along a first prescribed path. Coins of at least one selected denomination are displaced to follow a second prescribed path. The coins are discharged along each prescribed path at exit locations at the periphery of the plate.

Abstract: A coin sorter in which a sorting head is positioned over a rotating pliable disc and wherein coins are sorted by the combination of an outwardly extending tapered edge and a series of pins generally positioned in an outwardly extending line spaced from the tapered edge. The spacing between the line of pins and tapered edge increases with outward dimension, whereby coins of different diameter are urged over the tapered edge by different pins at different positions. The coins are then captured between the head and pliable disc and rotated to exit positions which are unique for each coin about the outside of the sorting head.

Abstract: A coin-queueing head for use in a high-speed coin-sorting and counting apparatus is provided using a spiral coin-processing channel. Coins are fed from a central loading area through an infeed opening into an infeed area having a height permitting unrestricted outward travel of the coins to a peripheral limit having a generally helical shape. The coins are then fed into a coin-processing channel having a first portion for partially separating face-stacked coins. The coins then pass to a second ramped channel portion providing a gradual depessing of the coins and a sudden release into a third channel portion. An inwardly positioned camming lobe and an outwardly positioned expanded area are provided to facilitate lateral separation of the coins upon their release from the second channel portion.

Abstract: A coin sorter of the type wherein coins are sorted by the combination of a sorting head and rotated resilient disc in which the inner edge of the coins are radially referenced as they rotate, and coins of a discrete diameter of ejected at discrete circumferential points by a series of ramp-slot combinations in which the radially positioned ramp depresses a discrete diameter of coin into a slot. The slots are configured to direct coins caught in a slot outward.

Abstract: A coin sorter in which a sorting head is positioned over a rotating pliable disc and wherein coins are sorted by the combination of an outwardly extending tapered edge and a series of pins generally positioned in an outwardly extending line spaced from the tapered edge. The spacing between the line of pins and tapered edge increases with outward dimension, whereby coins of different diameter are urged over the tapered edge by different pins at different positions. The coins are then captured between the head and pliable disc and rotated to exit positions which are unique for each coin about the outside of the sorting head.