In Response To Centrifugal Force Patents (Class 494/4)
  • Patent number: 11344898
    Abstract: In at least one embodiment, the invention provides a retrofit for existing water treatment systems where the retrofit includes at least one of the following: a particulate separator, a supplementary inlet, and a waveform disk-pack turbine. In a further embodiment, the invention includes a water treatment system combined with at least one of the following: a particulate separator, a supplementary inlet, and a waveform disk-pack turbine.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: May 31, 2022
    Assignee: QWTIP LLC
    Inventor: Whitaker B. Irvin, Sr.
  • Patent number: 11052409
    Abstract: A method of supervising and controlling an E-line position in a centrifugal separator and a centrifugal separator include the E-line positon being continuously calculated based on inter alia, monitored density of light and heavy liquid phases, and monitored pressure at outlet side of light and/or heavy liquid outlet passages. First and/or second valves are controlled to control the E-line position, based on the supervised E-line position.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: July 6, 2021
    Assignee: ALFA LAVAL CORPORATE AB
    Inventors: Leonard Borgström, Peter Thorwid
  • Patent number: 11045750
    Abstract: The invention in at least one embodiment includes a system for treating water having an intake module, a vortex module, a disk-pack module, and a motor module. In a further embodiment, a housing is provided over at least the intake module and the vortex module and sits above the disk-pack module. In at least one further embodiment, the disk-pack module includes a disk-pack turbine having a plurality of disks having at least one waveform present on at least one of the disks.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: June 29, 2021
    Assignee: QWTIP LLC
    Inventor: Whitaker B. Irvin, Sr.
  • Patent number: 10821220
    Abstract: A continuous flow centrifuge bowl includes a rotatable outer body, and a top and bottom core that are rotatable with the outer body. The bottom core has a wall extending proximally from a bottom wall. The proximally extending wall is radially outward from at least a portion of the top core and, together with the top core, defines a primary separation region in which initial separation of the whole blood occurs. The bowl may also have a secondary separation region located between the top core and the outer body, and a rotary seal that couples an inlet port and two outlet ports to the outer body. The inlet port may be connected to an inlet tube that extends distally into a whole blood introduction region. Additionally, one of the outlet ports may be connected to an extraction tube that extends into a region below the bottom core.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: November 3, 2020
    Assignee: Haemonetics Corporation
    Inventors: Matthew Murphy, Dominique Uhlmann, Edward Powers, Michael Ragusa, Etienne Pagès
  • Patent number: 9956555
    Abstract: This disclosure is directed to an apparatus, system and method for retrieving target material from a suspension. A system includes a processing vessel, a displacement fluid, and a tube. The tube includes a funnel, a cannula, and a cavity. The cannula allows for fluid communication between the funnel and the cavity, such that the processing vessel is inserted into the cavity, and the cannula extends into the processing vessel.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: May 1, 2018
    Assignee: RareCyte, Inc.
    Inventors: Lance U'Ren, Ronald Seubert
  • Publication number: 20150018190
    Abstract: A solid bowl screw-type centrifuge used to continually separate a composition of substances with different densities includes a rotor drum, rotatable about a horizontal axis, with a cylindrical drum section and a conical drum section, and a conveying screw mounted therein, rotating about the same axis, with a helical vane attached to a hollow shaft for transporting the heavy phase to discharge openings in the conical drum section. On a front wall closing the cylindrical drum section, at least one outflow opening for the light phase is provided with a device for setting the fluid level. The device for setting the fluid level is composed of a control element with a system for braking or accelerating the fluid particles of the light phase, which is rotatively driven at a speed different to the drum speed and releases a flow through an annular clearance to the inner wall of the drum.
    Type: Application
    Filed: March 21, 2013
    Publication date: January 15, 2015
    Applicant: HILLER GMBH
    Inventors: Heinz Solscheid, Robert Wagenbauer
  • Publication number: 20150005149
    Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
    Type: Application
    Filed: September 17, 2014
    Publication date: January 1, 2015
    Inventors: JOHN E. NASH, WILLIAM T. FISHER, Douglas G. Evans
  • Publication number: 20140287903
    Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
    Type: Application
    Filed: June 3, 2014
    Publication date: September 25, 2014
    Applicant: Kensey Nash Corporation
    Inventors: John E. Nash, William T. Fisher
  • Publication number: 20130344496
    Abstract: A fluidic centripetal apparatus for testing components of a biological material in a fluid is presented. A bottom-fillable chamber is coupled to an entry channel for receiving the fluid, the chamber inlet being provided at an outer side of the bottom-fillable chamber. A container is wholly provided in a retention chamber and contains a liquid diluent, until it releases it upon application of an external force, restoring the fluidic connection between the liquid diluent and the fluid in the retention chamber. The retention chamber can have a flow decoupling receptacle for receiving the fluid, located at the outer side of the retention chamber and interrupting a fluidic connection between the entry and exit of the retention chamber. A test apparatus and a testing method using a fluidic centripetal device for testing components of a biological material in a fluid are also provided.
    Type: Application
    Filed: March 7, 2012
    Publication date: December 26, 2013
    Inventors: Régis Peytavi, Sébastien Chapdelaine
  • Patent number: 8591391
    Abstract: A separation system for separating a multiple component material into at least two fractions. The separation system includes a separation device having a first end, a second end opposite to the first end, and a sidewall that extends between the first end and the second end to define a separation chamber having an interior volume. The system also includes a valve moveable between an open position and a closed position, the valve is mounted at a fixed location within the separation chamber at a position that is closer to the second end than to the first end and is spaced apart from the second end, the valve is operable to isolate a first fraction of the multiple component material having a first density on a first side of the valve from a second fraction having a second density on a second side of the valve that is opposite to the first side.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: November 26, 2013
    Assignee: Biomet Biologics, LLC
    Inventors: Jason Chavarria, Michael D. Leach
  • Publication number: 20130244856
    Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
    Type: Application
    Filed: February 13, 2013
    Publication date: September 19, 2013
    Inventors: John E. Nash, William T. Fisher, Douglas G. Evans
  • Publication number: 20130226150
    Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma while retaining the platelets and other factors. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
    Type: Application
    Filed: February 18, 2013
    Publication date: August 29, 2013
    Inventors: John E. Nash, William T. Fisher
  • Patent number: 8511480
    Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: August 20, 2013
    Assignee: ThermoGenesis Corp.
    Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
  • Patent number: 8511479
    Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: August 20, 2013
    Assignee: ThermoGenesis Corp.
    Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
  • Patent number: 8506823
    Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: August 13, 2013
    Assignee: ThermoGenesis Corp.
    Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
  • Publication number: 20130133250
    Abstract: A fluid filtration system using a rotating container, comprising a shell having an inlet pipe installation port and an outlet port, the inlet pipe installation port and the outlet port are located on the same or opposite side (end) of the shell, and having some distance from the outermost edge of the shell, such that said rotating container can retain fluid during rotation. Stirring blades are placed inside the shell of said rotating container, which rotate with the shell synchronously. The purification process includes the injection of the fluid into the rotating container, which can withhold liquid during high-speed rotation. When the fluid in the rotating container swirls at high speed, substances of higher densities will accumulate at the internal wall of the rotating container away from the rotation axis, whereas substances of lower densities will accumulate at the inner ring region closer to the rotation axis.
    Type: Application
    Filed: November 1, 2012
    Publication date: May 30, 2013
    Applicant: DR. T LIMITED
    Inventor: Dr. T Limited
  • Publication number: 20130029829
    Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma while retaining the platelets and other factors. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
    Type: Application
    Filed: August 7, 2012
    Publication date: January 31, 2013
    Applicant: KENSEY NASH CORPORATION
    Inventors: John E. Nash, William T. Fisher
  • Patent number: 8221299
    Abstract: Membrane-encased structures such as biological cells, liposomes, and vesicles, are conveyed through one or more channels in a rotating disk for individual exposure to optical elements or to electrodes, for purposes of transfection or flow cytometry. The rotation of the disk serves either to provide centrifugal force to urge the cells against one wall of the channel and in certain embodiments to move the cells through the channels, or to draw cells at preselected times or intervals into the exposure zone, or all three.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: July 17, 2012
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Charles W. Ragsdale
  • Patent number: 8177072
    Abstract: A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: May 15, 2012
    Assignee: ThermoGenesis Corp.
    Inventors: John R. Chapman, Vijay Kumar, Brian K. Cinquini, Phillip D. Kingsley
  • Publication number: 20120115705
    Abstract: The present invention relates to methods, devices and systems for separation and concentration of particles from liquid and fluid samples. In some embodiments, the separation/concentration is achieved by sequential centrifugation steps. In particular, one aspect of the invention relates to a separation/concentration device which comprises at least a first chamber (101) and a second chamber (103) connected by a first valve (111), whereby operation of the first valve controls the material transfer from the first chamber to the second chamber. In some embodiments, valve operation can be manually, semi-manually or automatically. Other aspects of the invention relate to single- or multi-chambered separation/concentrator devices, and methods and systems for use. Other aspects of the invention relate to devices for operation of the valves, e.g., semi-manual actuation devices, and automatic inertial activation devices and mechanical actuation devices present in purpose-built centrifuges.
    Type: Application
    Filed: April 30, 2010
    Publication date: May 10, 2012
    Applicants: Fraunhofer USA, Inc., Trustees of Boston University
    Inventors: Andre Sharon, Alexis Sauer-Budge, Aaron Size, Holger Wirz
  • Patent number: 8105495
    Abstract: A process for separating platelet rich plasma from a blood sample using a platelet rich plasma separator system is disclosed. The system includes an inner wall having a top edge and a central axis that is surrounded by a depth filter having a capacity to receive all of the erythrocytes in the blood sample, where an inner surface of the inner wall has an angle of about 0.2° from the central axis of the inner wall. The process includes spinning the inner cylinder at its central axis at a speed that separates the erythrocytes from plasma and platelets and causes the erythrocytes to collect against an inner surface of the depth filter. The cylinder is continually spun for a sufficient time to allow substantially all of the erythrocytes to flow up the inner surface and over the top edge into the depth filter, leaving platelet enriched plasma (PRP) in the inner cylinder, such that upon discontinuing the spinning, permits the platelet enriched plasma to flow to the bottom of the inner cylinder.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: January 31, 2012
    Assignees: Hanuman, LLC, Biomet Biologics, LLC
    Inventors: Randel Dorian, Michael D. Leach
  • Patent number: 8096422
    Abstract: Disclosed is a separator-concentrator, such as for separating and concentrating platelet-rich-plasma (PRP) from whole blood that is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly and a concentrator assembly. The centrifugal separation assembly comprises a centrifugal drum separator and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: January 17, 2012
    Assignees: Hanuman LLC, Biomet Biologics, LLC
    Inventors: Randel Dorian, Michael D. Leach
  • Publication number: 20110251041
    Abstract: A separation system for separating a multiple component material into at least two fractions. The separation system includes a separation device having a first end, a second end opposite to the first end, and a sidewall that extends between the first end and the second end to define a separation chamber having an interior volume. The system also includes a valve moveable between an open position and a closed position, the valve is mounted at a fixed location within the separation chamber at a position that is closer to the second end than to the first end and is spaced apart from the second end, the valve is operable to isolate a first fraction of the multiple component material having a first density on a first side of the valve from a second fraction having a second density on a second side of the valve that is opposite to the first side.
    Type: Application
    Filed: April 12, 2010
    Publication date: October 13, 2011
    Applicant: Biomet Biologics, LLC
    Inventors: Jason Chavarria, Michael D. Leach
  • Patent number: 7824559
    Abstract: A PRP separator-concentrator comprising a housing, a separation assembly, and a concentration assembly. The concentration assembly has a concentration sump. An axially concentric rigid stationary outlet tube is secured to the housing and extends through the separation assembly to the sump. The separation assembly is attached to and positioned above the concentration assembly to form a combined separator-concentrator assemblage that is rotatable about the outlet tube. The separation assembly includes a separation chamber lined with a depth filter having pores and passageways that are sized to receive and entrap erythrocytes during centrifuging. The concentration chamber has a floor for supporting desiccated beads and a wall with at least one opening closed with a screen. The concentrator can have a distribution of upright screen supports, the upright screen supports having an inner surface and an outer surface, the cylindrical screen being supported on the outer surface of the upright screen supports.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: November 2, 2010
    Assignees: Hanumann, LLC, Biomet Biologics, LLC
    Inventors: Randel Dorian, Michael D. Leach
  • Publication number: 20100167899
    Abstract: A hermetically sealed solids discharge centrifugal separator exhibits low-shear filling, acceleration, and separation of feed material. The separator can be particularly useful for separation and recovery of sensitive solids such as chemical or biological substances. The separator accommodates disposable sample contacting elements to eliminate the need for clean-in-place and sterilize-in-place operations. Some embodiments of the separator feature dual solids discharge pistons, which fully optimize recovery of valuable solids.
    Type: Application
    Filed: December 29, 2009
    Publication date: July 1, 2010
    Inventor: Robert B. Carr
  • Patent number: 7695423
    Abstract: A system for automatically collecting and separating whole blood into its components is described. The system includes a console, which contains all motors, pumps, sensors, valves and control circuitry, and a unique disposable set that includes a cassette supporting a centrifuge with an improved design, pump interfaces with an improved design, component and solution bags, and tubing. Various processes are implemented using a specific disposable set for each process which allows automatic identification of the process to be performed the console.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: April 13, 2010
    Assignee: Terumo Medical Corporation
    Inventors: Thomas C. Robinson, Thomas P. Robinson, Richard D'Elia, Thomas Sahines, Paul Eibe
  • Publication number: 20090298665
    Abstract: A flexible, disposable centrifuge bag for receiving and holding a fluid sample, comprising one or more tubes and upper and lower flexible sheets having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters to define an outer perimeter of the centrifuge bag. The inner perimeter of the bag defines a central core. The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.
    Type: Application
    Filed: May 21, 2009
    Publication date: December 3, 2009
    Applicant: ARTERIOCYTE MEDICAL SYSTEMS
    Inventors: Victor D. Dolecek, David Malcolm
  • Publication number: 20090215602
    Abstract: Blood separation methods and systems are provided for mid-processing calculation of blood composition. Blood is conveyed into a device having an outlet line and the device is spun to separate a blood component from the blood. A flow of blood component is conveyed from the device by the outlet line and the blood component in the outlet line is optically measured. With said optical measurement, a current blood component yield, a blood component pre-count, the volume of blood to process to collect a target amount of said blood component, and/or the processing time required to collect a target amount of said blood component is calculated. The optical measurement can also be used to calculate an amount of storage fluid to convey into a collection container with the blood component.
    Type: Application
    Filed: February 27, 2009
    Publication date: August 27, 2009
    Inventors: Kyungyoon Min, Richard I. Brown
  • Patent number: 7481977
    Abstract: A device for fluid assay comprising a carousel (12), mounted about a hub (14), disposed in a complementary shaped housing (16). The carousel (12) is divided into a plurality of chambers (20, 22, 24, 26, 28, 30) disposed radially about the hub (14). The chambers (20, 22, 24, 26, 28, 30) are arranged into pairs which are disposed diametrically opposite one another and which communicate with each other via the hub (14).
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: January 27, 2009
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: David Alan Percival, David Aubrey Plumptre
  • Publication number: 20080081755
    Abstract: A centrifugal separating-distributing apparatus includes a body being provided with an intake path, a stacking path, and a distributing path. A fluid sample is taken into the intake path, and the sample flows out from an outlet of the path when a first centrifugal force is exerted at a first rotation angle position. Under the first centrifugal force, the flown out sample flows in an inlet of the stacking path and is separated into plural components and the components are stacked in the stacking path. When a second centrifugal force is exerted at a second rotation angle position, a component closest to the inlet of the stacking path flows into an inlet of the distributing path between the outlet of the intake path and the inlet of the stacking path, and is moved away from the inlet to be separated from the remainder of the components in the stacking path.
    Type: Application
    Filed: March 15, 2007
    Publication date: April 3, 2008
    Applicant: KABUSHIKI KAISHA TOSHIBA
    Inventors: Takeshi Kinpara, Hajime Sudo, Kenji Ooki, Tomokazu Domon
  • Patent number: 7241281
    Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into container adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the container to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: July 10, 2007
    Assignee: ThermoGenesis Corporation
    Inventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs
  • Patent number: 6971525
    Abstract: A centrifuge with combinations of multiple features is disclosed. In one aspect, a centrifuge for removing more dense material from a fluid medium includes a fluid separation wall placed within a sleeve. The fluid separation wall rotates around the axis of rotation. A receptacle aids in separation of the more dense material from the fluid medium. The receptacle defined in a part by a respective geometry and a respective shape. An opening extends from the void area to the outer surface to transport the more dense material to the containment zone. An excitation apparatus associated with the receptacle creates a vibration within the receptacle. The centrifuge may further include a valve ring including a valve orifice the valve ring having a first position which blocks the more dense material from exiting the receptacle and a second position that allows the more dense material to move into the containment zone.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: December 6, 2005
    Assignee: Phase Inc.
    Inventors: Curtis Kirker, Berkeley F. Fuller
  • Patent number: 6855102
    Abstract: Method of separating cells in a centrifuge, preferably for producing platelets. A cell suspension is provided in a processing bag and is centrifuged. The cell enriched fraction is transferred to a storage bag via an outlet tube. The outlet tube is arranged with a portion thereof in a position adjacent the periphery of the centrifuge. When the enriched fraction is transferred through the outlet tube placed at the periphery of the centrifuge and during centrifugation, the outlet tube operates as a cell trap and the enriched fraction is further separated. Preferably, the cell suspension is buffy coat and the enriched fraction comprises platelets. The corresponding bag assembly comprises a processing bag intended to enclose the cell suspension. The processing bag is placed in a centrifuge rotor for separating the cells into a fraction enriched on platelets by centrifugation.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: February 15, 2005
    Assignee: Gambro Inc
    Inventors: Peter Unger, Eric Westberg
  • Patent number: 6823238
    Abstract: A method and apparatus selective remove undesirable low gravity components from the return stream of drilling mud. The apparatus receives mud returned from the well borehole and transfers the mud to a tank. Mud from the tank is treated in a separation system including a plurality of mass flow sensor to monitor operation of the system.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: November 23, 2004
    Assignee: Hutchison Hayes L.P.
    Inventors: Gary L. Hensley, Lee Hilpert
  • Patent number: 6607473
    Abstract: A fluid mixture containing a heavy component and a light component is separated by feeding the fluid mixture into a vessel. The vessel includes a light component outlet regulated by a first valve and a heavy component outlet regulated by a second valve. The vessel is rotated about a rotational axis extending through the vessel as the liquid-liquid mixture is feed into the chamber such that the heavy component collects toward at least a portion of the peripheral wall of the vessel radially outward from the rotational axis and the lighter component collects toward the rotational axis. The first valve is set such that the light component exits therethrough at a first pressure. The second valve is set such that the heavy component exits therethrough at a second pressure, the second pressure being different than the first pressure.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: August 19, 2003
    Assignee: Econova Inc.
    Inventor: Kevin E. Collier
  • Patent number: 5935051
    Abstract: A separator and a method for quickly separating an aliquot of plasma or serum from cells in a sample of blood is provided herein. The separator includes a housing which defines a separation container, an outlet aperture, a valve which selectively seals the outlet aperture, and a spinner. Initially, the spinner rotates the housing at a separation speed which causes the heavier cells to separate from the serum or plasma. Subsequently, the spinner rotates the housing at a faster, expellant speed which causes the valve to open and the cells to be expelled through the outlet aperture. After the cells have been expelled from the separation container, rotation of the housing is stopped and the serum or plasma is collected from the separation container. Since the separator provided herein does not use a separation gel, the separator is easy to clean and reusable.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: August 10, 1999
    Assignee: Beckman Instruments, Inc.
    Inventor: Michael L. Bell
  • Patent number: 5913767
    Abstract: A worm centrifuge for separating solids/liquid mixtures is disclosed for overcoming the problems during start-up and shut-down processes that occur when quantity of a liquid is located or remains in the centrifuge drum, particularly the problem of the emergence of liquid at the solids discharge openings during the shut-down process. The inventive centrifuge includes at least one, preferably a plurality of, drum emptying openings distributed over the circumference of the face wall of the centrifuge drum and being positioned radially outside of the liquid discharge openings. The drum emptying openings are each radially crossed by a bore. The bores each include a centrifugal force valve having a spring-loaded closing member adapted to close the drum emptying opening at high drum speed (operating speed) and to open the drum emptying opening at low drum speed.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: June 22, 1999
    Assignee: Baker Hughes (Deutschland) GmbH
    Inventors: Bernward Feldkamp, Reinhold Boden, Brigitta Stender
  • Patent number: 5830352
    Abstract: A reagent delivery system comprises an axial hub passing through the center of two equal-diameter, spaced apart discs, wherein the hub and discs are positioned in a sleeve such that an annular reagent chamber is provided. When the sleeve is moved in either an up or down axial direction the so-formed chamber is opened and the reagent is released. Such a regent delivery system is particularly useful in a centrifuge for concentrating or preparing blood products.
    Type: Grant
    Filed: December 1, 1995
    Date of Patent: November 3, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventor: Niels Erik Holm
  • Patent number: 5618409
    Abstract: The centrifuge (1) described has at least one device (11,12) designed to control the operation of the centrifuge, the devices being mounted to rotate with the rotating part of the centrifuge and to be operated by a mechanical actuator (13) also rotating with it. Such devices may, for instance, be drain valves, periodically opening discharge valves, sill height adjustment devices, pressure-control devices, temperature-control devices, etc. At least one part of the devices of this centrifuge to be controlled independently of the centrifugal force is designed so that the rotating actuator (13) changes its shape as a function of the temperature and has at least one temperature-specific shape.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: April 8, 1997
    Assignee: FLottweg GmbH
    Inventor: Walter Kreill
  • Patent number: 5334130
    Abstract: A vial holding a material such as an organic liquid-containing biological specimen is received in the receptor of a holder assembly, the assembly further including a centrifugal valve. The holder is mounted on a rotor in a centrifugal vacuum concentrator and the specimen is then subjected to a treatment such as drying in the vacuum chamber. Vapor from the drying vents into the concentrator vacuum chamber, the centrifugal valve which is a normally closed component opens due to imposition thereon of centrifugal force created during and attending rotor speed above a certain RPM. At completion of the treatment and before the rotor falls from its certain RPM, a dried material protective gas blanket can be flowed into the vial, the valve closing to seal the vial and protected contents when RPM of the rotor falls below the certain RPM.
    Type: Grant
    Filed: May 13, 1992
    Date of Patent: August 2, 1994
    Assignee: Savant Instruments, Inc.
    Inventors: Michael Glater, Carlos Barreda, Yury Zlobinsky
  • Patent number: 5041075
    Abstract: A continuous-operation centrifuge drum for concentrating suspended solids. The concentrated solids are diverted out of an outer solids space through channels into an inner chamber, whence the concentrated solids are continuously extracted. At least one vortical-outflow space is positioned between the channels and the inner chamber, with the points of which the medium enters the channels distributed around the outer demarcation of the outflow space and with the outlet from the outflow space extending from a radially outward region in the outflow space to the inner chamber. A separate vortical-outflow space is associated with each channel. Each outflow space consists of two demarcating surfaces, preferably extending in planes perpendicular to the axis of rotation of the drum, and of a surrounding wall that connects them, and extends radially to a multiple of its axial length.
    Type: Grant
    Filed: March 7, 1989
    Date of Patent: August 20, 1991
    Assignee: Westfalia Separator AG
    Inventors: Paul Bruning, Ulrich Wrede
  • Patent number: 4882094
    Abstract: Disposal container structure for the disposal of waste radioactive materials includes inner structure comprising a cover member with an inlet port and an annular seal surface portion, and depending filter structure attached to the cover structure that includes circumferential side wall structure and bottom wall structure that defines an enclosed chamber volume in which waste materials are introduced for storage therein through the inlet port. The container structure further includes outer structure that has circumferential side wall structure corresponding in shape to the filter structure of the inner structure, bottom wall structure that defines a chamber for receiving the filter structure of the inner component, and annular seal surface structure formed on the side wall structure for mating with seal surface structure of the inner structure to seal the storage chamber volume defined by the filter structure.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: November 21, 1989
    Assignee: Foster-Miller, Inc.
    Inventors: Leslie S. Rubin, Hans A. Hug
  • Patent number: 4729759
    Abstract: The invention resides in the provision of a sludge recirculation controlled in this manner within the centrifuge rotor itself. For this reason there has been arranged centrally in the rotor, apart from a previously known reception chamber (10) for separated sludge, a recirculation chamber (14) to which sludge is transferred from the reception chamber (10). An overflow outlet (15) maintains a free liquid surface in the recirculation chamber (14) at a predetermined radial level. Recirculation channels (16), which are formed so that the flow therethrough will automatically be controlled depending upon the viscosity of the separated sludge, will conduct such sludge from the recirculation chamber (14) back to the radially outermost parts of the separation chamber (5).
    Type: Grant
    Filed: February 20, 1987
    Date of Patent: March 8, 1988
    Assignee: Alfa-Laval Separation AB
    Inventors: Goran Krook, Per Karlsson
  • Patent number: 4720284
    Abstract: In a method of separating different density fluid components, a fluid sample is placed in a first flexible container. The container and its contents are then spun at high speed while controlling the shape of the container so that its side walls spread apart and its bottom flattens to give the container and its contents a relatively small aspect ratio whereby different density components of the fluid contents travel minimum distances while separating in the container to achieve a density distribution in the container, with the densest components of the fluid distal to the spin axis being distributed over a relatively large area surface constituted by the container bottom. The method is particularly applicable to separating different components of human blood. Various apparatus for practicing the method are also disclosed.
    Type: Grant
    Filed: October 3, 1986
    Date of Patent: January 19, 1988
    Assignee: Neotech, Inc.
    Inventor: Read S. McCarty
  • Patent number: 4585558
    Abstract: A separation system for dewatering radioactive waste materials includes a disposal container, drive structure for receiving the container, and means for releasably attaching the container to the drive structure. Separation structure disposed in the container adjacent the inner surface of the side wall structure retains solids while allowing passage of liquids. Inlet port structure in the container top wall is normally closed by first valve structure that is centrifugally actuated to open the inlet port and discharge port structure at the container periphery receives liquid that passes through the separation structure and is normally closed by second valve structure that is centrifugally actuated to open the discharge ports. The container also includes coupling structure for releasable engagement with the centrifugal drive structure.
    Type: Grant
    Filed: September 19, 1984
    Date of Patent: April 29, 1986
    Assignee: Foster-Miller, Inc.
    Inventor: Leslie S. Rubin
  • Patent number: 4543083
    Abstract: A centrifuge for separating first and second liquids having different specific gravities includes a container supported for rotation about an axis, a drive arrangement for rotating the container, a supply arrangement for introducing a mixture of the liquids into the container, a valve arrangement supported on the container and in fluid communication with and responsive to fluid pressure in a radially outermost portion of the container for discharging quantities of the first liquid from such portion of the container to the region external to the container during rotation of the container, and an arrangement for removing from the container during rotation thereof quantities of the second liquid.
    Type: Grant
    Filed: June 6, 1984
    Date of Patent: September 24, 1985
    Assignee: Crude Oil Quality Control Corporation of Michigan
    Inventor: Jerry O. Bounds
  • Patent number: 4417884
    Abstract: A timing and control mechanism for a centrifuge comprising a piston to which is attached a cam having cam surfaces which interact with flexible tubing to control the rate of flow through the tubing. The velocity of the piston in the centrifugal force field is determined by the resistance to flow of fluid which the piston displaces. The movement of the cam is therefore a measure of the speed and duration of the centrifugal force.
    Type: Grant
    Filed: July 9, 1981
    Date of Patent: November 29, 1983
    Assignee: Haemonetics Corporation
    Inventors: Donald W. Schoendorfer, Allen Latham, Jr.
  • Patent number: 4410317
    Abstract: A self-discharging centrifugal drum for clarifying and separating suspensions has an axially displaceable piston valve that is bounded above by a solids space and that opens and closes expulsion openings in the drum jacket. A closure compartment that can be charged with closure fluid is disposed below the piston valve and into which the closure fluid is supplied through a channel that is connected to an intermediate compartment for closure fluid. The closure compartment is evacuated to initiate discharge of the drum packing by a centrifugal valve. The valve that evacuates the closure compartment is a centrifugal valve that contains a movable valve cone, with the valve cone activated by control fluid and having a valve projection that is smaller in diameter than the valve cone and that is sealed into the drum jacket behind the valve cone so that the valve projection will extensively choke or close the channel that connects the closure compartment to the intermediate compartment when the valve cone opens.
    Type: Grant
    Filed: April 29, 1982
    Date of Patent: October 18, 1983
    Assignee: Westfalia Separator AG
    Inventors: Hugo Zurbruggen, Karl-Heinz Zettier
  • Patent number: 4392845
    Abstract: Discharge nozzles are provided in centrifugal separator drums for the continuous discharge of the concentrate separated in the drum, and are inserted into the drum wall from the outside for the sake of ease of installation and cleaning. To enable the discharge orifice to aim itself correctly tangential to the drum circumference during operation and against the direction of rotation of the drum, there is provided opposite a locking projection on the discharge nozzle, an additional, excentrically disposed projection. The center of gravity of the rotatable discharge nozzle lies in this projection, so that, under the action of centrifugal force when the drum is rotating, the center of gravity of the discharge nozzle will set itself, even if incorrectly aligned at installation, on an axis that is radial to the drum axis. The discharge orifice is aimed opposite to the direction of drum rotation at an angle of 90.degree. to the gravity axis.
    Type: Grant
    Filed: November 25, 1981
    Date of Patent: July 12, 1983
    Assignee: Westfalia Separator AG
    Inventor: Hubert Gunnewig