Abstract: The invention relates to a centrifuge provided with a blood bag system having an upper and lower outlet for separation of blood constituents, containing a rotor which can be driven in a rotative manner about a hub, wherein at least one conventional whole blood bag equipped with an upper outlet and with a lower outlet can be positioned vertically in this blood bag, while the whole blood bag can be arranged on the rotor in such a way that one outlet of the whole blood bag is bent in a radial direction, and the opposite outlet of the whole blood bag is bent in the other radial direction, so that the entire whole blood bag and the outlets thereof adopt an approximately Z- or S-shaped form in its functional position. In this case it is preferred that the upper outlet of the whole blood bag lie radially toward the interior and the lower outlet of the whole blood bag lie radially toward the exterior of the whole blood bag.

Abstract: Systems and methods centrifugally separate whole blood into red blood cells, plasma, and a platelet concentrate. The systems and methods rotate a first rotating separation zone about a rotational axis, to separate whole blood into red blood cells and plasma constituent carrying platelets. Red blood cells separated are directed in a first circumferential flow direction toward a terminal wall, where blood flow is halted. Surface hematocrit is successively increased in the first circumferential flow direction by separating the plasma constituent from the red blood cells. Separated red blood cells are directed from the first rotating separation zone through a path where the surface hematocrit is the most. Plasma constituent separated is directed in a second circumferential flow direction opposite to the first circumferential flow direction toward a different region in the first rotating separation zone, where the surface hematocrit is the least.

Abstract: Blood processing systems and methods establish on line communication between a container and a source of blood containing leukocytes and platelets, such as a human donor. The systems and methods create a centrifugal field between the source of blood and the container that separates from the blood an unfinished suspension of platelets having a first physiologic characteristic different than the desired physiologic characteristic. The systems and methods pump the unfinished platelet suspension outside the centrifugal field through a finishing device. The finishing device changes the first physiologic characteristic to the desired physiological characteristic, thereby creating the finished platelet suspension. The systems and methods convey the finished platelet suspension from the finishing device directly into the container. The systems and methods function without interrupting the on line communication between the container and the source of blood.

Abstract: A blood processing assembly comprises a frame rotatable about a rotational axis and a blood processing chamber carried by the frame for rotation about the rotational axis. An umbilicus has one end coupled to the blood processing chamber along the rotational axis and an opposite end held in a non-rotating position along the rotational axis. A mid region of the umbilicus extends, at least in part, outside the rotational axis. The frame carries at least one support channel, which is sized and configured to engage the mid region of the umbilicus. The support channel includes a side edge that is sized and configured to self-load the mid region of the umbilicus into the support channel in response to rotation of the frame in a designated direction.

Abstract: Blood separation systems and methods introduce blood into an annular separation channel between a low-G wall and a high-G wall while rotating the separation channel about an axis, for separation of the blood into blood components. The annular separation channel has an annular boundary wall. The systems and methods direct a first blood component into a constricted channel along the low-G wall. The systems and methods remove the first blood component through a first path that communicates with the separation channel through an opening that adjoins the constricted channel adjacent the low-G wall. The systems and methods direct a second blood component along a surface that extends generally in an axial direction along the high-G wall toward the annular boundary wall. The systems and methods collect the second blood component through a second path that communicates with the separation channel through an opening that adjoins the surface adjacent the high-G wall axially spaced from the annular boundary wall.

Abstract: A centrifuge is provided for the separation and/or treatment of cells in a substantially annular or partially annular separation bag connected by at least one tube to at least one secondary bag. The centrifuge comprises a rotor bowl connected at the upper end of a rotor shaft. The rotor shaft includes a hollow upper portion defining a central compartment for receiving the at least one secondary bag. The rotor bowl includes a separation compartment for receiving the separation bag and an expandable hydraulic chamber located within the separation compartment for selectively squeezing the separation bag within the separation compartment so as to transfer a separated component from the separation bag into a secondary bag in the central compartment. A hydraulic system is connected to the hydraulic chamber by a duct extending through the rotor shaft for pumping a hydraulic liquid to and from the hydraulic chamber.

Abstract: The present invention relates generally to a fractionator for collecting at least one of a plurality of segregated components from a segregated sample disposed in a sample tube. The fractionator has a head with a head surface at its forward end. The head may be configured to form a slideable seal with the inside surface of a sample tube. A collection port is disposed forward of the head surface, and a fluid passageway is in fluid communication with the collection port and is configured and arranged to allow fluid transport from the sample tube to a sample receptacle. The fractionator may have a valve in fluid communication with the collection port and may have a valve controller configured and arranged to operate the valve based, at least in part, on the location of the collection port with respect to a sample disposed in the sample tube.

Abstract: A method and an apparatus for continuous processing of intra- or postoperative blood loss for autotransfusion. According to the present invention, certain cells of the cell suspension to be processed, mainly the red blood cells, are concentrated by centrifuging in a separation unit and removed from the separation unit without being rinsed or washed in the separation unit. The concentrated cell fraction is diluted with a physiological solution, preferably a Ringer's solution, after being removed from the separation unit.

Abstract: A blood separation chamber comprises a base that includes formed walls that define a hub. A separation channel extends about the hub. A flow passage extends between the hub and the separation channel. The hub enables attachment of external tubing to convey blood to and from the separation channel through the hub.

Abstract: A centrifuge with controlled discharge of dense materials disclosed. A centrifuge includes a fluid separation wall placed within a sleeve to form a containment zone therebetween. The fluid separation wall aligns and rotates parallel to an axis of rotation. A receptacle forming a part of the fluid separation wall includes a void area. An opening extending through the fluid separation wall from the void area to the outer surface of the receptacle transports the more dense material to the containment zone. A valve ring forming a part of the fluid separation wall includes a valve orifice. The valve ring aligned perpendicular to the axis of rotation and slides along the fluid separation wall to move between open and closed positions. The valve orifice aligns with the opening such that the more dense material exits the fluid separation wall and moves into the containment zone.

Abstract: Systems and methods for processing blood use at least one fluid activated pump and at least one fluid activated valve. The systems and methods apply positive and negative fluid pressures to operate the pump and valve. Different pressure conditions are applied to the pump and the valve, to insure that a valve used in conjunction with a pump is not overcome by the pressure applied to operate the pump, and that both the valve and pump are not overcome by normal system processing pressures.

Abstract: The present invention provides an apparatus for separating components of a fluid having an outer housing containing a core wherein three separate fluid pathways are provided to allow continuous separation of biological fluids.

Abstract: A system for separating biological fluids into components, comprises a set of containers for the biological fluid to be separated and the separated components, optionally an additional container for additive solution, and a hollow centrifugal processing chamber having an axial inlet/outlet for the biological fluid. The processing chamber contains a piston movable to intake a selected quantity of biological fluid and express processed biological fluid components via the outlet. Optical means monitor the position of piston to control the amount of intaken fluid and the expression of components. A distribution valve arrangement selectively communicates the processing chamber and the containers or places them out of communication. The system is arranged to operate in a seperation mode and in a non-separation transfer mode, especially for adding preservative solution to separated blood stem cells.

Abstract: A blood processing assembly comprises a frame rotatable about a rotational axis and a blood processing chamber carried by the frame for rotation about the rotational axis. An umbilicus has one end coupled to the blood processing chamber along the rotational axis and an opposite end held in a non-rotating position along the rotational axis. A mid region of the umbilicus extends, at least in part, outside the rotational axis. The frame carries at least one support channel, which is sized and configured to engage the mid region of the umbilicus. The support channel includes a side edge that is sized and configured to self-load the mid region of the umbilicus into the support channel in response to rotation of the frame in a designated direction.

Abstract: Blood separation systems and methods introduce blood into an annular separation channel between a low-G wall and a high-G wall while rotating the separation channel about an axis, for separation of the blood into blood components. The annular separation channel has an annular boundary wall. The systems and methods direct a first blood component into a constricted channel along the low-G wall. The systems and methods remove the first blood component through a first path that communicates with the separation channel through an opening that adjoins the constricted channel adjacent the low-G wall. The systems and methods direct a second blood component along a surface that extends generally in an axial direction along the high-G wall toward the annular boundary wall. The systems and methods collect the second blood component through a second path that communicates with the separation channel through an opening that adjoins the surface adjacent the high-G wall axially spaced from the annular boundary wall.

Abstract: A centrifuge bucket, for holding a first article, further comprises a compartment for holding a second article, and an arrangement for securing the compartment to an outer surface of the centrifuge bucket.

Abstract: A system for the production of autologous thrombin, comprising a centrifuge including a blood reservoir for receiving and separating an autologous anticoagulated blood sample having multiple inactive blood components and means for removing at least one of said inactive blood components upon separation, and a dispenser having at least two collection chambers for receiving said at least one of said inactive blood components, wherein a first collection chamber activates a first portion of said inactive blood component and stores the resulting coagulated blood component comprising a clot and said autologous thrombin.

Abstract: Systems and methods separate blood cells from whole blood and pump the separated blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter has a filtration medium enclosed within a flexile housing. The systems and methods employ a fixture to restrain expansion of the flexible filter housing during operation of the pump. The fixture has a bracket to enable its releasable attachment to the blood processing device employed to carry out the separation process.

Abstract: A centrifugal processing bag, system and method for separating the components of a mixed material is presented. The processing bag includes a hub and a first port for receiving the mixed material, where the first port includes an outlet positioned within the processing bag at a perimeter of the bag. The processing bag also including a second port having a second port inlet spaced proximate the hub and away from a central axis of the hub. The second port directs a separated material collected from the second port inlet out of the processing bag.

Abstract: A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.

Abstract: A system compact enough to be located entirely beside the donor's chair, and able to process the blood while the donor is still resting in the chair after having donated the blood. The separated blood components (plasma and red blood cells) may be stored in their individual optimum environments immediately after the whole blood is drawn, and the blood does not need to be transported back to a separation laboratory for processing. The system includes a needle (72) (or other cannula-like device) for insertion into a vein of the donor and drawing whole blood therethrough, a rotor (2a) for holding the blood after it is drawn, and a motor (50) for spinning the rotor so as to cause the blood to separate into components, for example, plasma and red blood cells.

Abstract: A blood separation chamber comprises a base that includes formed walls that define a hub. A separation channel extends about the hub. A flow passage extends between the hub and the separation channel. The hub enables attachment of external tubing to convey blood to and from the separation channel through the hub.

Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into container adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the container to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.

Abstract: A device, system, and method are provided for separating blood components. The device includes a separation vessel for placement in a retainer of a rotatable centrifuge rotor. The separation vessel includes an inlet end portion, an outlet end portion, and a flow path extending from the inlet end portion to the outlet end portion. Blood components to be separated are supplied to the vessel via an inlet port at the inlet end portion, and separated blood components are removed via one or more outlet ports at the outlet end portion. The device also includes a leukocyte reduction filter including a porous filtration medium configured to filter leukocytes from at least some of the separated blood components removed from the vessel.

Abstract: A centrifuge system for the formation of an autologous platelet gel wherein all of the blood components for the gel are derived from a patient to whom the gel is to be applied. First a platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. The platelet rich plasma or platelet poor plasma is then automatically drawn out of the centrifuge bag and proportioned into separate chambers in a dispenser. The first portion is activated where a clot is formed and thrombin is obtained. The thrombin is then latter mixed with the second portion to obtain a platelet gel.

Abstract: A belt-driven blood centrifuge with side-mounted drive motor for rotating the centrifuge at a rotation speed selected to separate blood components. The centrifuge includes a drive shaft assembly rotated at an input rotation speed and a rotor assembly rotatably linked to the drive shaft assembly rotated at an output rotation speed twice the input rotational speed. A drive motor is provided with a drive pulley to drive a belt, a chain, and the like to provide the motive force to rotate the drive shaft at the input rotation speed. In one embodiment, a belt is provided to contact both the pulley of the drive motor and an outer surface of a rotatable shell of the drive shaft assembly. A base is included in the centrifuge upon which the drive shaft assembly is mounted. The drive motor is positioned adjacent the drive shaft assembly and mounted on the base.

Abstract: A centrifuge disposable having a collection chamber for receiving and holding a fluid to be centrifuged, the chamber having an outer perimeter, an inner perimeter, a generally circular cross-sectional area, and a conical outboard collecting portion. The collection chamber is typically formed from relatively rigid, molded plastic or other materials. The chamber further ports in communication near the outboard portions of the chamber to provide fluid communication to a tubing, which may be single lumen for discontinuous embodiments in which a single tube is used for fill and extraction and multi-lumen for continuous fill and extraction embodiments in which an inlet lumen is used for fill and one or more outlet lumens are used for extraction of separated components.

Abstract: This invention provides a centrifugal weir that may be placed in series with conventional piping between a source of contaminated liquid and a discharge point within an industrial setting. Further, this weir allows continuous flow from the source of contamination to the discharge point without requiring settling ponds or reservoir systems. The centrifugal forces generated on the liquid inside the rotating weir greatly accelerate settling of heavy solid material from the liquid. The invention further provides a simplified means of cleaning the centrifugal weir. In a second embodiment, the centrifugal weir uses a removable cartridge. The compact unit of the second embodiment may be used in dental offices to separate amalgam from rinse water and for limited wastewater handling in chemistry laboratories.

Abstract: Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.

Abstract: A centrifugal blood separator for separating whole blood into at least two blood fractions such as a plasma fraction and a blood cell fraction is disclosed. The blood separator has a centrifuge vessel with a separation chamber having at least two sections with different diametric sizes. The large diameter section collects the heavier blood cell fraction during centrifugation. The smaller diameter section collects the lighter plasma fraction. Fluid communication subassemblies preferably have a feed conduit, a product or an outflow conduit and a vent which are mounted in a non-rotatable part and positioned in an extending or extendible manner into the separation chamber to allow blood fractions to be removed while the centrifuge vessel is rotating or after rotation has stopped depending upon specifics of the particular embodiment.

Abstract: A blood separation chamber for rotation about an axis includes an interior channel, which includes a recess that extends outside the bounds of the walls establishing separation zone. The recessed interior channel permits the yields of individual blood components separated in the chamber to be. maximized without cross-contamination or contamination by other components present in the chamber.

Abstract: A centrifuge filter for removing soot from engine oil. The centrifuge filter includes a rotor adapted to be rotated inside a centrifuge housing by an electric motor or other means. The rotor preferably includes a reusable aluminum support casing and a disposable plastic cartridge. The plastic cartridge includes a trap with partition walls to prevent wave formation in the rotating liquid contained in the trap. The cartridge includes an annular inlet through its top end, a winding flow path through the cartridge and an outlet at the bottom enc. The centrifuge housing includes an isolated sealed rotor chamber. Using the venturi effect, air is evacuated from the rotor chamber to provide a partial vacuum to reduce air drag on the rotor. Resilient rubber vibration isolators are used to reduce vibrations and engine induced shock loads from reaching the rotating element. A side oil inlet is provided in the cartridge to receive unfiltered oil at a location offset from the axis of rotation.

Abstract: A centrifuge filter for removing soot from engine oil. The centrifuge filter includes a rotor adapted to be rotated inside a centrifuge housing by an electric motor or other means. The rotor preferably includes a reusable aluminum support casing and a disposable plastic cartridge. The plastic cartridge includes a trap with partition walls to prevent wave formation in the rotating liquid contained in the trap. The cartridge includes an annular inlet through its top end, a winding flow path through the cartridge and an outlet at the bottom. The centrifuge housing includes an isolated sealed rotor chamber. Using the venturi effect, air is evacuated from the rotor chamber to provide a partial vacuum to reduce air drag on the rotor. Resilient rubber vibration isolators are used to reduce vibrations and engine induced shock loads from reaching the rotating element. A side oil inlet is provided in the cartridge to receive unfiltered oil at a location offset from the axis of rotation.

Abstract: The present invention is a blood separation system that is fully mechanized to collect blood from a patient, separate waste portions of the blood, wash the blood, and redirect the usable portions to a device for reinjecting the usable portions into the patient. The present invention prevents accidental activation of an improper operation that could cause harm to a patient or a shut down of the system by requiring confirmation of each step by an operator. The invention provides screen displays with detailed setup instructions, eliminating the need for secondary documentation that might not be allowed in a surgical environment. The invention also instructs the operator at the appropriate times to do certain manual steps such as opening and closing clamps. Since the opening and closing of clamps is a highly critical operation, confirmation of these steps is also required.

Abstract: A centrifuge filter for removing soot from engine oil. The centrifuge filter includes a rotor adapted to be rotated inside a centrifuge housing by an electric motor or other means. The rotor preferably includes a reusable aluminum support casing and a disposable plastic cartridge. The plastic cartridge includes a trap with partition walls to prevent wave formation in the rotating liquid contained in the trap. The cartridge includes an annular inlet through its top end, a winding flow path through the cartridge and an outlet at the bottom enc. The centrifuge housing includes an isolated sealed rotor chamber. Using the venturi effect, air is evacuated from the rotor chamber to provide a partial vacuum to reduce air drag on the rotor. Resilient rubber vibration isolators are used to reduce vibrations and engine induced shock loads from reaching the rotating element. A side oil inlet is provided in the cartridge to receive unfiltered oil at a location offset from the axis of rotation.

Abstract: A blood separation chamber comprises a base that includes formed walls that define a hub. A separation channel extends about the hub. A flow passage extends between the hub and the separation channel. The hub enables attachment of external tubing to convey blood to and from the separation channel through the hub.

Abstract: A blood separation assembly comprises a blood processing chamber having a base including formed walls that define a separation channel. A centrifuge rotor is rotatable about a rotational axis. A latch assembly comprises a latch arm that is pivotally mounted on the centrifuge rotor. The latch arm can be moved between a chamber-retaining position engaging the blood processing chamber, to secure the blood processing chamber to the centrifuge rotor, and a chamber- releasing position free of engagement with the blood processing chamber, to enable removal of the blood processing chamber from the centrifuge rotor. The latch assembly also includes a pawl movable on the centrifuge rotor between a first position adjacent the latch arm and a second position spaced from the latch arm. The pawl includes a locking element that engages the latch arm when the latch arm is in the chamber-retaining position, to resist movement of the latch arm toward the chamber-releasing position.

Abstract: The invention relates generally to a method of separating swarf lubricant from swarf solids. A centrifuge parts separator utilizes a screen which preferably comprises a cylindrical shaped member formed in one or more component parts with a plurality of spaced fluid passage openings therein with the ratio of the distance between the center lines of adjacent openings (x) and the median width of the openings (y) being x/y of at least 18/1. The swarf is centrifuged in the separator during the course of which operation, substantially all the swarf fluid passes through the screen openings whereas substantially all the swarf solid passes over the screen, the separated swarf fluids and solids each being directed to a collection site.

Abstract: A system for transporting wet chips to a centrifugal separator where the wet chips are separated into dry chips and fluid with the dry chips being transported to a dry chips site and the fluid recirculated or collected. Preferably, the centrifugal separator, when actuated, serves to generate a pneumatic flow of air through a wet chip conduit whereby the wet chips are pneumatically conveyed to the separator from a source of origin such as a tooling machine station where wet chips are generated. A parts separator may be located at either end of the wet chip conduit.

Abstract: An automated blood separation method and apparatus is described that allows for the separation of multiple units of blood simultaneously. The method and apparatus reliably and quickly separates blood into its components. An auto-balancing feature within the apparatus automatically preferably compensates for the changing state of imbalance, thereby eliminating the need for additional balancing steps during the separation process. The apparatus has a rotor into which a plurality of cassettes can be inserted. The cassettes have a number of sections for the containment of the whole blood and for the separated blood components, which are contained in disposable bags. The rotor is placed into a centrifuge assembly, and the blood components are then separated and transferred to the bags in the individual sections of the cassettes. Means for including secondary separation devices such as filters is included.

Abstract: Blood processing systems and methods employ two sensors, one to detect a condition of plasma exiting a separation device and another sensor to detect a condition of a cellular component exiting the separation device. The first sensor detects, e.g., contamination of the plasma due to presence of unwanted cellular components. The second sensor detects, e.g., dilution of the cellular component due to presence of plasma. Blood processing parameters are carried out based, at least in part, by conditions detected by one or both of the sensors.

Abstract: A centrifuge with an associated container system in the form of cassettes for separation and/or treatment of blood or blood components. The centrifuge comprises a rotor having a central compartment in the form of a tubular shaft cavity extending concentrically with the axis of rotation of the rotor and an annular separation compartment which is arranged around said cavity at the upper part thereof. A first container system arranged in the rotor for washing of blood cells comprises a round bag with two or more flexible secondary containers connected thereto, of which at least one contains a treatment liquid, and a tubular sleeve adapted to the shaft cavity of the rotor. The secondary containers stand in the sleeve resting against each other, and the round bag is mounted on a projecting flange at the upper part of the sleeve.

Abstract: A blood separation chamber comprises a base that includes formed walls that define a hub. A separation channel extends about the hub. A flow passage extends between the hub and the separation channel. The hub enables attachment of external tubing to convey blood to and from the separation channel through the hub.

Abstract: Systems and methods for efficiently separating blood in a rotating field convey blood into a blood separation chamber through an inlet passage for separation into a blood component. The systems and methods convey the blood component from the separation chamber through an outlet passage. The systems and methods rotate the blood separation chamber about an axis in direction of blood flow in the flow path from the inlet passage toward the outlet passage. It has been discovered that, by rotating the chamber during blood separation in the same direction as the flow of whole blood from inlet to outlet disturbances due, e.g., Coriolis effects can be minimized, resulting in increased separation efficiencies.

Abstract: A suspension assembly for suspending components of a centrifugal separator from a floor or base plate. The assembly comprises two shafts fixed to each other at 90°, each shaft being disposed in bearing assemblies attached to the floor plate or pivot plate.

Abstract: Blood separation systems and methods draw whole blood from a blood donor selected from a population of blood donors. The whole blood of the selected blood donor has a known hematocrit value that varies within the population of blood donors according to morphology of the selected blood donor. The systems and methods operate a pump in the inlet line to convey a volume of whole blood from the donor at a commanded flow rate for processing into plasma constituent and concentrated red blood cells. The systems and methods set the commanded flow rate to vary the volume of whole blood conveyed over time as a function of the known hematocrit value of the selected donor. The systems and methods obtain, after processing the whole blood volume, a targeted volume of concentrated red blood cells, which is substantially constant for the population of blood donors despite variances in known hematocrit values among the donors.

Abstract: A classification system utilizing a cone which is rotated at a specified speed is provided. A stream including a solvent is introduced into the classification, and the stream impacts against the cone and flows along the inside face of the cone. The side of the cone is sufficiently long that the conic face filters the introduced flow, thereby removing substantial portions of the solvent and leaving the heavier or classified parts. The discharge from the cone is thus segregated liquids and solids, and the solid stream is a flow of classified particles and a portion of the solvent. The solvent portion is sufficient in volume to conduct the classified particles as a heavy or thick slurry out of the system. There is an interplay between the length of the cone, i.e. the length along which the introduced slurry must flow, also, the cone angle, and the pores through the cone wall.

Abstract: Apparatus for separating a biological component from a biological fluid are disclosed. The apparatus includes a chamber for receiving a biological fluid including a biological component, and a rotor for creating a centrifugal field within the chamber. A source of particles may be included wherein the particles have a binding site for selectively binding to the biological component. The particles may be aseptically introduced into the chamber. The apparatus may withdraw whole blood from a donor, separate the whole blood to obtain a target cell population and return a selected one of either the target cell population or at least a portion of the whole blood remainder to the donor or patient. A disposable separation inset for use in conjunction with a rotatable separation device such as the apparatus described above may also be provided.

Abstract: Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.

Abstract: A method for combining three different means of constructing the concentric layers of the outer collecting wall for industrial size centrifuges, whereby treating the inward-facing elements of easily cast or stamped materials using processes such as Physical Vapor Deposition, Chemical Vapor Deposition or metal plating, transforms them into an innermost member with superior hardness and durability, and whereby said wear surface member or deposited layer is physically supported by a middle composition layer made up of one or more investment castings designed to optimally transfer centrifugally-induced compression loads from the innermost wear surface toward the outer surface of the composite wall, such castings being of ceramic, metals or other materials, and whereby the outer surface of said composite wall is comprised of a filament-wound hoop strength reinforcement layer, using aramid, graphic, carbon or such fibers mixed and embedded in resin, such that all highly desirable characteristics for a centrifuge ou