Abstract: This invention relates to a dual phase mouthwash comprising a hydrophilic phase, a hydrophobic phase, and a hydrotrope, wherein the hydrophilic phase comprises an effective amount of a preservative selected from potassium sorbate, sodium benzoate, benzyl alcohol, and a combination thereof, and CPC and a monovalent acid, as well as to methods of using and of making such compositions.

Abstract: Alkaline ware wash detergents containing an alkali metal alkalinity source and alkanol amine phosphonate scale inhibitors and methods of employing the same for superior cleaning efficacy and hard water scale control are disclosed. Alkanol amine phosphonates beneficially reduce scale build-up, including calcium carbonate scale build-up from alkaline detergents used with hard water sources. Methods of employing the detergent compositions are also disclosed.

Abstract: The present invention relates to phenol containing disinfectants that have superior broad-spectrum antimicrobial efficacy versus traditional chemistry such as quaternary ammonium-containing disinfectants or aliphatic alcohols. Hydrotropic surfactants are utilized in combination with generally environmentally friendly phenol containing compounds such as ortho-benzyl parachlorophenol (OBPCP), ortho phenylphenol (OPP), or parachloro-meta-cresol (PCMC) in the presence of suitable solvents such as an aliphatic alcohol and also in the presence of an inorganic acid, such as phosphoric acid. The solutions are free of para tertiary amylphenol (PTAP), have a low pH and are very stable with respect to gamma irradiation. They can be used with respect to hard surface disinfection, and also as a tuberculocide, a fungicide, a bactericide, and a virucide.

Abstract: Antimicrobial compositions providing synergistic antimicrobial effects against a variety of bacterial, viral and fungal organisms are described. Methods for using the antimicrobial compositions and products containing the antimicrobial compositions are also described herein.

Abstract: A blood analysis apparatus configured such that a nozzle sucks a predetermined amount of a blood specimen in a specimen container, and dispenses the specimen to each blood cell counting part which obtains count data, and a control part processes the count data to perform blood analysis. In this apparatus, two or more blood cell counting parts (basophil counting part, LMNE counting part, red blood cell counting part, white blood cell counting part) are constituted to obtain the count data of the same particular blood cell type (white blood cells), and the control part calculates the ratio or number of the existing blood cell from each count data, and judges whether the amount of the blood specimen sucked in the nozzle is normal or insufficient by comparing respective calculation results to determine whether they are within the predetermined allowable ranges.

Abstract: The present invention discloses the method for cleaning a medical instrument using a treatment liquid, wherein the treatment liquid contains: (A) an alkanolamine in an amount of 0.004 to 1% by mass, (B) a nonionic surfactant in an amount of 0.002 to 1% by mass, (C) a polyhydric alcohol in an amount of 0.004 to 10% by mass, (D) an alkaline protease in an effective amount, and (E) water, and has a pH of not lower than 9.

Abstract: The present invention discloses multi-purpose metering fluid/rinse reagents for use in automated cellular analyzers that use liquid volumetric metering. The compositions contain a chelating agent, an ionizing salt, optionally a stabilizing ion, a buffer, a non-hemolytic surfactant, and optionally an antimicrobial agent. Advantageously, the compositions produce less than one part-per-million of formaldehyde over the course of one year. Methods for using the compositions are also described.

Abstract: The present invention relates to [1] a detergent composition for a washer for medical devices, including a nonionic surfactant (A) represented by the following formula (1), at least one compound (B) selected from the group consisting of fatty acids having not less than 6 and not more than 10 carbon atoms or salts thereof, a cationic surfactant (C) represented by the specific formula, and water; and [2] a method of washing a medical device using a washer for medical devices which includes the step of washing the medical device with a mixture including the above detergent composition and an enzyme.

Abstract: Liquid compositions for cleaning, in particular medical instruments and air conditioning surfaces, said composition excluding surfactants and comprising one or more enzymes including a protease and optionally a hydrolase, a solvent system including a water soluble glycol ether solvent, at least one anionic hydrotrope, and wherein the molar ratio of said at least one hydrotrope to said glycol ether in the composition is selected to preserve the activity of said one or more enzymes. The hydrotrope is advantageously an anionic hydrotrope selected from the group consisting of water soluble anionic hydrotropes of the formula (I) and having no alkyl side chain greater than six carbons in length, for example a xylene sulfonate or cumene sulfonate salt.

Abstract: A cleaning composition comprises A) a fatty alcohol-alkylene oxide copolymer, B) a glycoside, and C) a benzene sulfonate, wherein, the weight ratio of the component B and the component C is less than or equal to 5:1. The cleaning composition can be used as a detergent for cleaning medical appliances.

Abstract: A disinfectant solution comprising: an aldehyde; a polyol; one or more acetal derivatives formed by reaction of said aldehyde with said polyol; one or more surfactants selected from the general classes anionic, cationic, or non-ionic; one or more pH buffering agents selected from the group consisting of monosodium phosphate, disodium phosphate, trisodium phosphate, sodium tetraborate, sodium bicarbonate, sodium citrate, phosphoric acid, boric acid and citric acid. The invention also relates to a process of producing the disinfectant solution, and a method of disinfecting and/or sterilizing heat sensitive medical devices comprising treating the medical devices with the disinfectant solution of the invention.

Abstract: Described are compositions and methods for the removal of zinc-oxide eugenol-based temporary cements or root canal filling materials from a variety of surfaces including surfaces inside the oral cavity, such as teeth, as well as surfaces of objects located outside of the oral cavity, such as instruments and prostheses. In certain compositions, the resin-dentin bond between permanent cements and collagen-containing surfaces can be increased. The compositions are non-toxic, can be used inside the oral cavity, and do not require special disposal procedures.

Abstract: An antimicrobial solution for disinfecting instruments in an automatic sterilization device, the solution comprising: a peracid reaction product formed in situ from combining a liquid acetyl donor with a solid source of peroxide, wherein the in situ reaction takes place in the sterilization device, along with a containment and delivery ampule for use in an automatic sterilization device, and methods for disinfecting a medical instrument employing the inventive antibacterial solution.

Abstract: The present invention relates to a cleaning fluid, in particular a cleaning fluid for cleaning surfaces.

Abstract: A biodegradable concentrated neutral detergent composition comprises various chelate compounds, various corrosion inhibitors, an alkaline compound, at least one sequestrant, various surfactants and hydrotropes, and water. The detergent can be highly concentrated, has a good long term shelf life, and when diluted is very effective in cleaning metals such as surgical instruments and prevents corrosion resistance of the metal even in a hard water environment.

Abstract: A medical instrument cleaning concentrate and method for cleaning medical equipment. The method includes contacting the equipment with a cleaning concentrate dissolved in water. The cleaning concentrate contains (i) a biofilm permeation agent, (ii) a nonionic alkoxylated alcohol surfactant having an HLB ranging from about 5 to less than 8, wherein a weight ratio of (i) to (ii) in the cleaning concentrate based on 100 wt. % active ingredients ranges from about 0.5:1 to about 1.5:1, and (iii) and an inert diluents. After contacting the equipment with the cleaning concentrate dissolved in water, the contacted surfaces are rinsed to substantially remove detectible traces of the ingredients of the cleaning concentrate from the surfaces.

Abstract: Composition for the removal of biofilms present on a substrate, comprising at least one detergent component comprising at least one sequestering agent and at least one agent that is simultaneously a wetting and a dispersing agent, and at least one enzymatic component containing at least one protease, at least one laccase and at least one polysaccharidase

Abstract: The present invention relates to [1] a detergent composition for endoscope washers, including a nonionic surfactant (A) represented by the following formula (1), a branched-chain fatty acid having not less than 6 and not more than 10 carbon atoms or a salt thereof (B), a defoaming agent (C) and water, R—O—[(EO)m/(PO)n]—H??(1) wherein R represents a branched-chain alkyl group having not less than 7 and not more than 9 carbon atoms; EO represents an ethanediyloxy group; PO represents a propanediyloxy group; m and n each represent an average molar number of addition of the ethanediyloxy or propanediyloxy group in which m is a number of not less than 1 and not more than 30, and n is a number of not less than 2 and not more than 50; and the mark “/” represents that EO and PO may be added either in a random form or in a block form, and an order of addition of EO and PO is optional; and [2] a method of washing an endoscope using an endoscope washer, including the step of washing the endoscope with a mixture inclu

Abstract: The present invention relates to novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds of the invention are storage stable, water soluble and have low to no odor. Further, the compounds of the present invention can be formed from non-petroleum based renewable materials. The compounds of the present invention can be used as antimicrobials, and bleaching agents. The compounds of the present invention are also suitable for use as coupling agents.

Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.

Abstract: A composition for cleaning a medical instrument having a surface at least partially covered by a biofilm. The composition may include a first enzyme having a weight of less than about 10% of the total weight of the composition, a second enzyme having a weight of less than about 10% of the total weight of the composition, and a surfactant having a weight less than about 10% of the total weight of the composition. The second enzyme may be different from the first enzyme. Additionally, the composition may have a pH ranging from about 4 to about 12, and the composition may be configured to remove greater than about 90% of the biofilm from the medical instrument in less than about 10 minutes.

Abstract: Methods employing detergent compositions effective for reducing hard water scale and accumulation on hard surfaces, namely within food, beverage and pharmaceutical applications are disclosed. The detergent compositions employ phosphinosuccinic acid adducts in combination with an alkalinity source and optionally polymers, surfactants and/or oxidizers, providing alkaline compositions having a pH between about 10 and 13.5.

Abstract: The invention relates to 10H-benzo[g]pteridine-2,4-dione derivatives, to the production thereof, and to the use thereof.

Abstract: The present invention relates to reagents for use in deactivating nucleic acids and methods of making and using the same.

Abstract: An aqueous lubricant emulsion for medical or food apparatus, comprising: (a) 5 wt % to 30 wt % of a mineral oil; (b) 5 wt % to 30 wt % of an emulsifier system consisting of two emulsifiers selected from the group consisting of sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, oleyl alcohol ether, triethanolamine oleate, wherein the mass ratio of the two emulsifiers is in a range of 2:8 to 8:2; (c) 0.5 wt % to 5 wt % of one or more coemulsifiers selected from the group consisting of fatty alcohols, long-chain fatty acids, and diisooctyl succinate sulfonates; and (d) the balance of water. A method for washing medical or food apparatus including the step of subjecting the medical or food apparatus to a treatment using the lubricant emulsion according to the invention after a washing step for the medical or food apparatus is also described.

Abstract: The addition of alcohol plus acetate salts unexpectedly enhanced the tuberculocidal activity of glutaraldehyde, and decreased the fumes of glutaraldehyde from the formula of a high-level disinfectant.

Abstract: A method of cleaning an automatic biochemical analyzer, wherein the cleaning solution includes: at least one anionic surfactant, at least one nonionic surfactant, an alkali metal hydroxide, an alkali metal citrate, and a buffering agent stabilizing the pH value above 13.0. In some embodiments, the cleaning solution provides low residual rate of proteins, low residual rate of lipids, desirable within-batch repeatability in clinical testing, low level of cross-contamination, and low level of reactant deposit after cleaning, without affecting test results of the biochemical analyzer. In some embodiments, the cleaning solution has no corrosive effects on the liquid path and reaction cup of the analyzer. The ingredients of the cleaning solution may also be biodegradable.

Abstract: A medical surface cleaning composition and a method for cleaning waste treatment system components, medical instruments surfaces, and enzyme residue-containing surfaces. The composition includes a residue cleaning agent and a substantially non-water soluble nonionic surfactant having an initial Ross-Miles foam height in an aqueous solution at 25° C. of less than 10 millimeters. A weight ratio of residue cleaning agent to surfactant on 100 wt. % active ingredient basis ranges from about 0.05:1 to about 0.5:1, and wherein the residue cleaning agent and surfactant are biodegradable.

Abstract: The invention relates to a cleaner and/or disinfectant for medical and/or surgical elements and apparatuses which is formulated as a powder. It comprises at least one peroxide, at least one acylating agent for releasing peracetic acid from the peroxide in aqueous solution, and also at least one nonionic surfactant. According to the invention, it is provided that it comprises agents for adjusting a pH of a 2% strength aqueous solution to pH 7.5 to 9 and is formulated as granules, where peroxide and/or acylating agent are coated with nonionic surfactant.

Abstract: The present invention provides a liquid composition for removing dental cement from the surface of non-living objects, comprising i) an inorganic base; ii) a complexing agent; iii) optionally a surfactant; and iv) an aqueous solvent. In a preferred embodiment, the composition comprises a surfactant, and an aqueous solvent comprising water mixed with a polar solvent miscible with water, preferably alcohol. Said objects to be cleaned comprise workpieces and instruments used in restoration work. Said workpieces may comprise crowns, bridges, inlays, and other prostheses. Said instruments may, comprise, for example, tools used during the dental operation which contacted the cement.

Abstract: A medical instrument cleaning concentrate and method for cleaning medical equipment. The method includes contacting the equipment with a cleaning concentrate dissolved in water. The cleaning concentrate contains (i) a biofilm permeation agent, (ii) a nonionic alkoxylated alcohol surfactant having an HLB ranging from about 5 to less than 8, wherein a weight ratio of (i) to (ii) in the cleaning concentrate based on 100 wt. % active ingredients ranges from about 0.5:1 to about 1.5:1, and (iii) and an inert diluents. After contacting the equipment with the cleaning concentrate dissolved in water, the contacted surfaces are rinsed to substantially remove detectible traces of the ingredients of the cleaning concentrate from the surfaces.

Abstract: A medical waste pretreatment and/or conditioner composition comprising a lipid agglomeration inhibitor and a surfactant having an HLB value ranging from about 1 to less than about 5, wherein a weight ratio of agglomeration inhibitor to surfactant on 100 wt. % active ingredient basis ranges from about 0.015:1 to about 3:1.

Abstract: The present invention discloses the method for cleaning a medical instrument using a treatment liquid, wherein the treatment liquid contains: (A) an alkanolamine in an amount of 0.004 to 1% by mass, (B) a nonionic surfactant in an amount of 0.002 to 1% by mass, (C) a polyhydric alcohol in an amount of 0.004 to 10% by mass, (D) an alkaline protease in an effective amount, and (E) water, and has a pH of not lower than 9.

Abstract: Acetyl xylan esterases and variants thereof having perhydrolytic activity are provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. Multi-component peracid generation systems comprising an enzyme catalyst having perhydrolytic activity are also provided, as are methods of using the present enzyme catalyst to produce peroxycarboxylic acids. The polypeptide having perhydrolytic activity may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, paper pulp processing, and personal care applications.

Abstract: Acetyl xylan esterases and variants thereof having perhydrolytic activity are provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. Multi-component peracid generation systems comprising an enzyme catalyst having perhydrolytic activity are also provided, as are methods of using the present enzyme catalyst to produce peroxycarboxylic acids. The polypeptide having perhydrolytic activity may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, paper pulp processing, and personal care applications.

Abstract: A medical instrument cleaning concentrate and method for cleaning medical equipment. The concentrate contains an active ingredient consisting essentially of (i) a biofilm permeation agent and (ii) a nonionic alkoxylated alcohol surfactant having an HLB ranging from about 5 to about 8, wherein a ratio of (i) to (ii) in the concentrate ranges from about 2:1 to about 4:1.

Abstract: There is provided a hydrogelator that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A hydrogelator comprising a lipid peptide represented by Formula (1): (where R1 represents an aliphatic group having 9 to 21 carbon atoms; R2, R3 and R4 independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atom(s) which may have a branched chain having 1 or 2 carbon atom(s), a phenylmethyl group or a —(CH2)n—X group, and at least one of R2, R3 and R4 represents a —(CH2)n—X group; n represents the number of 1 to 4; X represents an amino group, a guanidino group, a —CONH2 group or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which may have 1 to 3 nitrogen atom(s)) or a salt thereof, and a hydrogel comprising the hydrogelator.

Abstract: A method for monitoring cleaning of a surface includes applying an amount of transparent indicator material to an area of a surface and measuring the amount of transparent indicator material remaining on the surface. The transparent indicator material may be fixed on the surface by drying and, when a fluorescent material, may be measured through exposure to ultraviolet radiation.

Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

Abstract: A non-toxic enzymatic detergent for use in cleaning surgical instruments and the like which have a large build-up of bio-residue thereon and which need specialty cleaning in order to avoid both hardened bio-residue and certain fluid traces from the instruments for both operating accuracy as well as sterilization requirements.

Abstract: A biofilm-removing agent which effectively removes biofilms is provided. A biofilm-removing agent containing a basic amino acid derivative represented by the following formula (1) or a salt thereof: (wherein R1 represents a linear- or branched-alkyl group having 4 to 18 carbon atoms or a linear- or branched-alkenyl group having 4 to 18 carbon atoms; X and Y each represent a group selected from the groups represented by the following formulas: and m represents an integer from 1 to 5).

Abstract: There is disclosed a cleaning composition comprising (i) 0.1 to 10 percent by weight of the cleaning composition of a biofilm removing detergent solution comprising a combination of an alkyl (C8-18) polysaccharide, a non-ionic surfactant and a nitrogen containing surfactant-biocide (ii) 2 to 80 percent by weight of the cleaning composition of one or more polar solvent (iii) 0.5 to 15 percent by weight of the cleaning composition of one or more primary amine (iv) two or more chelating agents (v) 0.1 to 5.0 percent by weight of the cleaning composition of an alkaline buffer system providing a pH of about 11.5 to 13.3 in aqueous solution (vi) 0.005 to 5.0 percent by weight of the cleaning composition of an alkoxyaminosilane. Also disclosed is a process of cleaning, decontaminating and/or passivating metallic surgical instruments and/or equipment using the composition of the invention.

Abstract: The disclosure relates to an enzyme stabilization system, compositions with the enzyme stabilization system, and methods of using the enzyme composition. Preferred ratios of acid to amine are effective at stabilizing enzyme. Optional nonionic surfactants and solvents also positively contribute to enzyme stability. The compositions are useful in cleaning applications.

Abstract: An alkaline composition having a pH ranging from about 8.5 to about 10 comprising a first substantially hydrophilic nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 12 to about 15; a second substantially hydrophilic nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 16 to 20; a bio-film permeation agent; and an aqueous solvent, wherein a total amount of the first substantially hydrophilic nonionic alkoxylated alcohol surfactant and the second substantially hydrophilic nonionic alkoxylated alcohol surfactant in the alkaline composition ranges from about 2 to about 20 percent by weight of a total weight of the alkaline composition.

Abstract: The invention relates to the use of an agent that contains 5 to 99.9% by weight of carbamide and/or at least a derivative thereof, as a cleaning agent e.g. for closed systems, in particular as a dishwasher detergent, as a laundry detergent for washing machines, as an agent for cleaning, sanitizing and/or disinfecting for equipment in the food processing industry and for medical equipment, the use as a hand dishwashing detergent or sanitary cleaner or as a hand cleaner.

Abstract: A method for cleaning contaminated surfaces of surgical waste management equipment. The method includes rinsing surfaces of the equipment with water to remove water soluble contaminants and waste material. A rinse solution is applied to the surfaces of the equipment to provide a residual film thereon. The rinse solution includes a first nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 12 to about 15, a second nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 16 to 20, an aqueous solvent, and a bio-film permeation agent. A total of the first surfactant and the second surfactant in the composition ranges from about 2 to about 20 percent by weight of a total weight of the composition.

Abstract: The present disclosure generally relates to a method for cleaning a shaving device using a cleaning solution and preparation of the cleaning solution. More particularly, the present disclosure relates to a method of cleaning a shaving device using an environmentally friendly cleaning solution.

Abstract: Methods of cleaning a medical device are provided via exposing the medical device to a compressed CO2-based mixture. The compressed CO2-based mixture includes carbon dioxide, a surfactant, and water in the form of water-in-CO2 microemulsions. In one particular embodiment, the ratio of water-to-surfactant mixed together in the CO2 has a range of about 5-100 molecules of water per molecule of surfactant (e.g., about 5-30 molecules of water per molecule of surfactant).

Abstract: A microbicidal and decontaminant composition comprising an aqueous solution of peroxides and peracids having equilibrium reaction products, a photoreactive surfactant, and a polymer, wherein said polymer interacts with said peroxides and said peracids.

Abstract: A method for monitoring cleaning of a surface includes applying an amount of transparent indicator material to an area of a surface and measuring the amount of transparent indicator material remaining on the surface. The transparent indicator material may be fixed on the surface by drying and, when a fluorescent material, may be measured through exposure to ultraviolet radiation.