Enzyme Composition Patents (Class 510/530)
  • Patent number: 6121226
    Abstract: Cotton soil release polymers comprising water soluble and/or dispersible, modified polyamines having functionalized backbone moieties and improved stability toward bleach. Also, laundry detergent compositions comprising these cotton soil release polymers having enhanced hydrophilic soil removal benefits in combination with a protease enzyme system are provided.
    Type: Grant
    Filed: July 16, 1999
    Date of Patent: September 19, 2000
    Assignee: The Procter & Gamble Company
    Inventors: Eugene Paul Gosselink, Kenneth Nathan Price, Chanchal Kumar Ghosh
  • Patent number: 6113655
    Abstract: The present invention relates to detergent compositions comprising a pectinesterase, including dishwashing, hard surface cleaning, and laundry compositions. The compositions are useful for significant overall cleaning performance and stain/soil removal benefits. In particular, the compositions are useful for removal of body, plant, fruit juice, and vegetable juice soils and stains.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: September 5, 2000
    Assignee: Procter & Gamble Company
    Inventors: Shuichi Tsunetsugu, Rosa Laura Moese, Andre Cesar Baeck, Ivan Maurice Alfons Jan Herbots
  • Patent number: 6110884
    Abstract: This invention is a protease mutant wherein said mutant substitutes the naturally occurring tyrosine amino acids for other amino acids at positions 91, 167, 171, 192, 209, 214, and 263. The protease mutants are used in detergent compositions.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: August 29, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Grethe Rasmussen, Egon Nielsen, Torben Halkier
  • Patent number: 6107265
    Abstract: Disclosed are cellulase compositions containing one or more endoglucanase components and less than about 5 weight percent of CBH I type components. When incorporated into detergent compositions and used in acidic, neutral, or alkaline washing media, such cellulase compositions impart color retention/restoration properties as well as improved softening properties to cotton-containing fabrics. Additionally, such compositions impart reduced strength loss to cotton-containing fabrics as compared to cellulase compositions containing greater amounts of CBH I type components.
    Type: Grant
    Filed: November 15, 1993
    Date of Patent: August 22, 2000
    Assignee: Genencor International, Inc.
    Inventors: Kathleen A. Clarkson, Edmund Larenas, Sharon Shoemaker, Geoffrey L. Weiss
  • Patent number: 6107264
    Abstract: There is provided an enzymatic bleach composition comprising one or more surfactants and an enzyme of extracellular origin, capable of oxidizing substrates by the build-in of one or more oxygen atoms into the substrate using molecular oxygen, in particular a dioxygenase from extracellular origin, and a process for bleaching stains present on fabrics comprising treating the stained fabrics with said composition.
    Type: Grant
    Filed: December 16, 1997
    Date of Patent: August 22, 2000
    Assignee: Lever Brothers Company, division of Conopco, Inc.
    Inventors: Marcel van der Helm, Monique van der Heiden, Dirk Herman Hondmann, Annelies Smits, Ton Swarthoff, Cornelis Theodorus Verrips
  • Patent number: 6093562
    Abstract: The present invention relates to variants of a parent .alpha.-amylase, which parent .alpha.-amylase (i) has an amino acid sequence selected from the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, and SEQ ID No. 7, respectively; or (ii) displays at least 80% homology with one or more of these amino acid sequences; and/or displays immunological cross-reactivity with an antibody raised against an .alpha.-amylase having one of these amino acid sequences; and/or is encoded by a DNA sequence which hybridizes with the same probe as a DNA sequence encoding an .alpha.-amylase having one of these amino acid sequences; in which variant:(a) at least one amino acid residue of the parent .alpha.-amylase has been deleted; and/or(b) at least one amino acid residue of the parent .alpha.-amylase has been replaced by a different amino acid residue; and/or(c) at least one amino acid residue has been inserted relative to the parent .alpha.-amylase; the variant having .alpha.
    Type: Grant
    Filed: February 13, 1996
    Date of Patent: July 25, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Henrik Bisg.ang.rd-Frantzen, Allan Svendsen, Torben Vedel Borchert
  • Patent number: 6087315
    Abstract: The present invention relates to protease variants, stabilized towards the inactivation caused by peroxidase systems, in which protease variants a naturally occurring tyrosine residue has been deleted or substituted with a different amino acid residue at one or more positions. The invention also relates to a method of stabilizing a protease towards the inactivation caused by peroxidase systems, and detergent compositions comprising a protease variant of the invention.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: July 11, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Grethe Rasmussen, Egon Nielsen, Torben Halkier
  • Patent number: 6080573
    Abstract: There is provided an enzymatic oxidation process wherein a substance which is to be oxidised is reacted with (a) an enzyme exhibiting peroxidase activity and a source of hydrogen peroxide or an enzyme exhibiting oxidase activity on phenolic compounds and (b) a compound which enhances the oxidation activity of the enzyme, characterized in that the compound specifically binds the substance which is to be oxidized. Furthermore, there is provided an enzymatic stain bleaching or anti dye-transfer composition comprising: (a) an enzyme exhibiting peroxidase activity and a source of hydrogen peroxide or an enzyme exhibiting oxidase activity on phenolic compounds and (b) a compound which enhances the oxidation activity of the enzyme and which is capable of binding selectively to a stain chromophore or textile dye in solution.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: June 27, 2000
    Assignee: Lever Brothers Company, Division of Conopco, Inc.
    Inventors: Daniel Convents, Rudolf Willem Pieter van Drunen, Cornelis Theodorus Verrips
  • Patent number: 6077316
    Abstract: This invention relates to a process for the treatment of fabrics. More specifically the invention relates to a process for the treatment of fabrics, which process comprises treating the fabric at elevated temperatures with an effective amount of a thermostable lipolytic enzyme.
    Type: Grant
    Filed: January 16, 1998
    Date of Patent: June 20, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Henrik Lund, Thomas Erik Nilsson, Tom Pickard
  • Patent number: 6077818
    Abstract: The present invention relates to detergent compositions comprising a cellulase termination composition and cellulase in order to prevent potential tensile strength loss related to the hydrolytic activity of cellulase on cellulose substrates while maintaining the desired benefits from the use of cellulase.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: June 20, 2000
    Assignee: The Procter & Gamble Company
    Inventors: Andre Cesar Baeck, Alfred Busch, Andre Christian Convents, Olivier Paquatte
  • Patent number: 6074631
    Abstract: The present invention relates to the use of one or more oxidoreductases in combination with a mediator for the reduction of malodor. Malodor reducing compositions and products comprising such composition are also claimed.
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: June 13, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Rie Tsuchiya, Bent Riber Petersen, S.o slashed.ren Christensen
  • Patent number: 6071356
    Abstract: The present invention relates to methods of cleaning-in-place soiled process equipment comprising circulating a solution comprising a protease and a lipase for a sufficient period of time to permit action of the enzymes.
    Type: Grant
    Filed: January 7, 1998
    Date of Patent: June 6, 2000
    Assignee: Novo Nordisk Als
    Inventor: Hans Sejr Olsen
  • Patent number: 6060299
    Abstract: Novel mannanases may be derived from eg Bacillus subtilis strain 168 or may be encoded by polynucleotide molecules comprising a nucleotide sequence as shown in SEQ ID NO: 1. The mannanases are alkaline and are useful e.g. in cleaning compositions, for modifying plant material, and for treatment of cellulosic fibres.
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: May 9, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Kotikanyadanam Sreekrishna, Kevin Johnstone, Charles Saunders, Jean-Luc Bettiol
  • Patent number: 6046149
    Abstract: There is provided a detergent composition containing an amylase enzyme and a builder system comprising an aluminosilicate zeolite, a crystalline layered silicate and most preferably an organic polymeric compound wherein the weight ratio of said crytalline layered silicate to said amylase enzyme (120 KNU/gram activity basis) is from 7:1 to 20:1. In one preferred aspect the detergent composition contains a bleaching system capable of providing delayed release of an organic peroxyacid to a wash solution.
    Type: Grant
    Filed: March 2, 1999
    Date of Patent: April 4, 2000
    Assignee: Procter & Gamble Company
    Inventors: Graham Alexander Sorrie, Alison Lesley Main
  • Patent number: 6030933
    Abstract: The present invention relates to detergent compositions comprising one or more enzymes which are immobilized by a covalent binding on an activated polymer. Such enzymes are preferably bound to the activated polymer via a spacer molecule. The enzymes are selected from a variety of enzymes including, for example, cellulases, hemicellulases, peroxidases, proteases, glucoamylases, amylases, lipases, cutinases, pectinases, reductases, oxidases, phenoloxidases, lipoxygenases, laccases, ligninases, pullulanases, xylanases, tannases, pentosanases, manlanases, .beta.-glucanases, arabinosidases, and mixtures thereof. The polymer is selected from a variety of polymers. A preferred polymer for use in the present invention is polyethylene glycol.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: February 29, 2000
    Assignee: The Procter & Gamble Company
    Inventors: Ivan Maurice Alfons Jan Herbots, Madeleine Petronella Jansen, Andre Cesar Baeck, Jean Wevers
  • Patent number: 6017871
    Abstract: The present invention relates to cleaning compositions comprising protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions corresponds to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin).
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: January 25, 2000
    Assignee: The Procter & Gamble Company
    Inventors: Andre Baeck, Chanchal Kumar Ghosh, Thomas Paul Graycar, Richard Ray Bott, Lori Jean Wilson, Philip Frederick Brode, Bobby Lee Barnett, Donn Nelton Rubingh
  • Patent number: 6017751
    Abstract: Cellulose-containing fabric is desized by treating with an enzyme hybrid having a catalytically active amino acid sequence of an enzyme such as a lipase or an amylase linked to an amino acid sequence containing a cellulose-binding domain. The enzyme amino acid sequence may be of an .alpha.-amylase obtainable from a species of Bacillus such as Bacillus licheniformis, or of a lipase obtainable from a species of Humicola, Candida, Pseudomonas or Bacillus. The cellulose-binding domain may be from a cellulase, a xylanase, a mannanase, an arabinofuranosidase, an acetylesterase or a chitinase. The enzyme hybrid is obtained from a transformed host cell containing an expression cassette having a DNA sequence encoding the enzyme hybrid. A desizing composition is formed containing the enzyme hybrid and a wetting agent.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: January 25, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Claus von der Osten, Mads E. Bjornvad, Jesper Vind, Michael Dolberg Rasmussen
  • Patent number: 6017874
    Abstract: The present disclosure relates to a liquid detergent composition comprising a surfactant system which is free of linear alkyl benzene sulfonate. The detergent composition comprises a selected quaternary ammonium surfactant, and an anionic surfactant selected from the group consisting of alkyl alkoxy sulfates and alkyl sulfates.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: January 25, 2000
    Assignee: The Procter & Gamble Company
    Inventors: Dimitris Lappas, Rajan Keshav Panandiker, Thomas Wilhelm Horner
  • Patent number: 6017870
    Abstract: A purified novel cellulase composition is provided which may be isolated from a fermentation culture of Trichoderma longibrachiatum and has a molecular weight of about 95-105 kD as approximated on SDS-PAGE (see FIG. 1), a pl of about 5.6-6.8 as estimated on an IEF gel and a pH optimum of about 5.0 on RBB-CMC when measured at 65.degree. C. and pH 4 or lower at temperatures of 40.degree. C. and 50.degree. C.
    Type: Grant
    Filed: October 9, 1996
    Date of Patent: January 25, 2000
    Assignee: Genencor International, Inc.
    Inventors: Benjamin S. Bower, Kathleen A. Clarkson, Katherine D. Collier, James T. Kellis, Moira B. Kelly, Edmund A. Larenas
  • Patent number: 6008178
    Abstract: There is provided a detergent composition comprising: a) from 1% to 95% by weight of a surfactant system comprising an anionic surfactant and a cationic ester surfactant, other than N,N-di(2-stearoyloxyethyl)-N-(2-hydroxyethyl)-N-methyl ammonium chloride, present in a weight ratio of said anionic surfactant to said cationic ester surfactant of 2.5:1 to 25:1; and b) from 0.0001% to 5% by weight of a proteolytic enzyme, wherein the % weight of proteolytic enzyme in the formulation is based on an enzyme activity of 4 Knpu/g of the enzyme particle, and wherein the weight ratio of said anionic surfactant to said proteolytic enzyme is at least 1.5:1.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: December 28, 1999
    Assignee: Procter & Gamble Company
    Inventors: Gerard Marcel Baillely, Robin Gibson Hall, Christian Leo Marie Vermote
  • Patent number: 5998342
    Abstract: This invention relates to a foaming enzyme composition and delivery method useful for the cleaning and maintenance of moist conditions of the surfaces of soiled instruments, utensils and other devices prior to final cleaning and/or sterilization. The aqueous composition preferably consists of a combination of: (1) an enzyme cleaning solution, (2) foam-building ingredients; (3) a corrosion inhibitor; and (4) an antimicrobial agent. The composition may be dispensed from a pump spray as a stable foam which covers the surfaces of the instrument to be cleaned, and remains on the surface of the instrument for at least 30 minutes, and preferably until the instruments are finally cleaned and sterilized. The composition and delivery method of the present invention is particularly useful for the pre-cleaning of complex medical instruments such as endoscopes.
    Type: Grant
    Filed: August 26, 1998
    Date of Patent: December 7, 1999
    Assignee: Cottrell International, LLC
    Inventors: John R. Scoville, Jr., Inna A. Novicova
  • Patent number: 5998350
    Abstract: The present invention relates to bleaching and detergent compositions comprising conventional detergent ingredients, bleaching systems with one or more bleach activators. Preferred bleaching activators are amido-derived bleach activators and/or N-acyl caprolactam bleach activators. The invention also relates to methods of using the detergent compositions.
    Type: Grant
    Filed: September 6, 1996
    Date of Patent: December 7, 1999
    Assignee: The Procter & Gamble Company
    Inventors: Michael Eugene Burns, Alan David Willey, Jerome Howard Collins, Richard Timothy Hartshorn, Chanchal Kumar Ghosh
  • Patent number: 5972872
    Abstract: The present invention relates to detergent compositions comprising an enzyme preparation with substantial cellulytic activity, especially endoglucanase activity, at alkaline conditions which is enzyme composition is derived from or producible by a fungus selected from the Basidiomycetous families Coprinaceae and Bolbitiaceae, preferably from the group of strains belonging to the genera Psathyrella, Podaxis, Panaeolus, Coprinus and Bolbitius, more preferably from the group of strains belonging to the species Coprinus micaceus, Coprinus domesticus, Coprinus ephemerus, Coprinus disseminatus, Coprinus radians, Coprinus picaceus, Coprinus frisei, Coprinus subimpatiens, Psathyrella candolleana, Psathyrella prona, Panaeolus semiovatus, Podaxis pistillaris and Bolbitius aleuriatus; and a method for providing a stone-washed look to textiles, especially to cellulosic fabric such as denim, using the mentioned enzyme preparation; and a method for improving the drainage of paper pulp or the de-inking of recycled paper usi
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: October 26, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Lene Lange, Jack Bech Nielsen, Martin Schulein
  • Patent number: 5972040
    Abstract: A granular detergent composition comprising an alkali metal percarbonate and an amylase enzyme, characterized in that said composition contains an amylase in a weight ratio of percarbonate to amylase of 1:2 to 300:1, preferably 1:2 to 60:1, more preferably 20:1 to 40:1. Both laundry detergent compositions including laundry additives and automatic dishwashing compositions are encompassed by the term "detergent composition" herein. Methods of treatment of specific stains are also encompassed.
    Type: Grant
    Filed: May 24, 1996
    Date of Patent: October 26, 1999
    Assignee: The Procter & Gamble Company
    Inventors: Michael Alan John Moss, Christiaan Arthur Thoen
  • Patent number: 5972873
    Abstract: The present invention relates to a liquid composition comprising an enzyme and a phenyl boronic acid derivative enzyme stabilizer of the following formula: ##STR1## wherein R is selected from the group consisting of hydrogen, hydroxy, C.sub.1 -C.sub.6 alkyl, substituted C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl and substituted C.sub.1 -C.sub.6 alkenyl.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: October 26, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Lone Kierstein Nielsen, Allison Deane-Wray
  • Patent number: 5972668
    Abstract: A process is presented for producing stable multi-enzyme containing granules. The process involves the steps of mixing a reversible competitive inhibitor with a first enzyme, adding a second incompatible enzyme, adding a carrier, extruding and granulating the resulting mixture and reducing the moisture content if necessary.
    Type: Grant
    Filed: July 3, 1997
    Date of Patent: October 26, 1999
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Meine Georg, Karl-Heinz Maurer, Albrecht Weiss, Kathleen Paatz, Ulrich Haas, Monika Boecker
  • Patent number: 5968887
    Abstract: The invention relates to a liquid composition which comprises an enzyme and a enzyme stabilizing component. The enzyme stabilizing component is a boronic acid derivative.
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: October 19, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Lone Kierstein Nielsen, Allison Deane-Wray
  • Patent number: 5967157
    Abstract: Automatic dishwashing detergent compositions comprising a nonionic surfactant having the formula:R.sub.1 O[CH.sub.2 CH(CH.sub.3)O].sub.x [CH.sub.2 CH.sub.2 O].sub.y [CH.sub.2 CH(OH)R.sub.2 ]wherein R.sub.1 is a linear or branched, aliphatic hydrocarbon radical having from about 4 to about 18 carbon atoms including mixtures thereof; R.sub.2 is a linear or branched aliphatic hydrocarbon radical having from about 2 to about 26 carbon atoms including mixtures thereof; x is an integer having an average value of from 0.5 to about 1.5; and y is an integer having a value of least about 15; employed in conjunction with a detersive enzyme such as amylase are provided.
    Type: Grant
    Filed: December 12, 1996
    Date of Patent: October 19, 1999
    Assignee: The Procter & Gamble Company
    Inventors: Kuntal Chatterjee, Graeme Duncan Cruickshank, Lynda Anne Jones, Eugene Steven Sadlowski
  • Patent number: 5965507
    Abstract: This invention concerns cleaning compositions like laundry compositions containing a chondroitinase enzyme. More in particular, the invention relates to compact detergent compositions, granular and liquids as well containing said chondroitinase enzyme.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: October 12, 1999
    Assignee: Procter & Gamble Company
    Inventors: Christiaan Arthur Jacques Thoen, Anju Deepali Massey Brooker, Youssef Oubrahim, Ian Martin Dodd
  • Patent number: 5948738
    Abstract: Stable liquid enzyme compositions containing an ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: September 7, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Masood A. Chowhan, Ronald P. Quintana, Bahram Asgharian, Bor-Shyue Hong, Thierry Bilbault, Ruth A. Rosenthal
  • Patent number: 5948746
    Abstract: The present invention relates to novel proteolytic enzymes. More specifically, the present invention relates to proteolytic enzymes obtainable from strains of Amycolata and Amycolatopsis. Moreover the invention relates to a process for the preparation of the proteolytic enzyme of the invention, as well as detergent additives and detergent compositions comprising the proteolytic enzyme.
    Type: Grant
    Filed: January 14, 1998
    Date of Patent: September 7, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Carsten Sj.o slashed.holm, Bjarne R.o slashed.nfeldt Nielsen, Claus Dambmann
  • Patent number: 5939369
    Abstract: Stable liquid enzyme compositions containing an ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: August 17, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Masood A. Chowhan, Ronald P. Quintana, Bahram Asgharian, Bor-Shyue Hong, Thierry Bilbault, Ruth A. Rosenthal
  • Patent number: 5935271
    Abstract: The present invention relates to laundry detergent compositions containing a lipolytic enzyme (lipase) and specially selected primary and/or tertiary amines. The compositions provide enhanced cleaning of grease/oil soils and stains, particularly when used in a pre-treat laundering process for cleaning fabrics stained with grease/oil soils.
    Type: Grant
    Filed: August 11, 1997
    Date of Patent: August 10, 1999
    Assignee: Procter & Gamble Company
    Inventors: Dimitris Lappas, Rajan Keshav Panandiker, Thomas Wilhelm Horner, Robert Walter Boswell
  • Patent number: 5932532
    Abstract: Bleaching and cleaning compositions comprising a bleaching compound, one or more bleach activators, and protease enzymes are provided. Thus, laundry detergent compositions which comprise protease, perborate or percarbonate and activators such as benzoyl caprolactain exhibit improved dingy clean-up performance.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: August 3, 1999
    Assignee: Procter & Gamble Company
    Inventors: Chanchal Kumar Ghosh, Gayle Marie Frankenbach, Catherine Michelle Quinn
  • Patent number: 5929017
    Abstract: A lipolytic enzyme with high activity at alkaline pH in the absence of Ca.sup.++ can be obtained from strains of filamentous fungi belonging to the genus Absidia. The lipolytic enzymes are effective for improving the effect of detergents towards fatty soiling.
    Type: Grant
    Filed: April 24, 1997
    Date of Patent: July 27, 1999
    Assignee: Novonordisk A/S
    Inventors: Erik Gormsen, Naoko Ikegami, Masanobu Abo, Shinobu Takagi, Noriko Tsutsumi, Torben Halkier
  • Patent number: 5928929
    Abstract: This invention is in the field of detergent proteases obtainable from strains of a new Bacillus sp. I 612. Moreover, the invention is directed towards a process for the preparation of the protease, the use of the protease as a detergent enzyme, and detergent compositions comprising the protease of the invention.
    Type: Grant
    Filed: July 2, 1997
    Date of Patent: July 27, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Helle Outtrup, Lars Sparre Conrad
  • Patent number: 5922082
    Abstract: The invention relates to a detergent composition having a wool compatible high alkaline protease with at least one mutation in each of the regions 96-110 and 123-135 according to the BPN'-numbering. The detergent composition is preferably substantially free of bleach and does contain so-called dye transfer inhibition technology.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: July 13, 1999
    Assignee: Procter & Gamble Company
    Inventors: Andre Cesar Baeck, Ann Katrien Marie Agnes Verschuere, Alfred Busch
  • Patent number: 5919271
    Abstract: The invention relates to a detergent composition which comprises a nonionic polysaccharide ether, a surfactant, a dye transfer inhibition agent, a cellulase enzyme and a chelating agents. In addition the invention further relates to a method of treating fabrics with the detergent composition.
    Type: Grant
    Filed: June 30, 1997
    Date of Patent: July 6, 1999
    Assignee: Procter & Gamble Company
    Inventors: Gerard Marcel Baillely, Robin Gibson Hall, Nour-Eddine Guedira
  • Patent number: 5914306
    Abstract: This invention relates to novel stabilized enzymes. More specifically the invention relates to novel stabilized enzymes, in which a naturally occurring amino acid residue (other than proline) has been substituted with a proline residue at one or more positions; at which position(s) the dihedral angles .phi. (phi) constitute values within the interval ?-90.degree.<.phi.<-40.degree.!; preferably the dihedral angles .phi. (phi) and .psi. (psi) constitute values within the intervals ?-90.degree.<.psi.<-40.degree.! and ?-180.degree.<.psi.<-150.degree. or -80<$g c)<10 or 100<.psi.<180!; and which positions(s) is/are not located in regions in which the enzyme is characterized by possessing .alpha.-helical or .beta.-sheet structure. The invention also relates to nucleotide sequences encoding the novel stabilized enzymes, and expression vectors and host organisms containing the nucleotide sequences. This invention also relates to detergent compositions comprising the stabilized enzymes.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: June 22, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Allan Svendsen, Claus von der Osten, Ib Groth Clausen, Shamkant Anant Patkar, Kim Borch
  • Patent number: 5904736
    Abstract: In washing agents containing tensides and cellulase, the properties of the cellulase which are relevant to the application were to be improved. This was essentially achieved in that use was made of a cellulase mixture in which the first component, with a CMCase activity of 1 U per liter and a protein concentration of a most 3 mg per liter, gives an increase in remission of at least 5 units in the secondary washing test and the second component, with a CMCase activity of 20 U per liter gives an increase in absorption in the cellulose decomposition test of at least 0.075.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: May 18, 1999
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Karl-Heinz Maurer, Albrecht Weiss
  • Patent number: 5888797
    Abstract: This invention is in the field of detergent proteases obtainable from a strain of a new Bacillus sp. ZI 315. Moreover, the invention is directed towards a process for the preparation of the protease, the use of the protease as detergent enzyme, and detergent compositions comprising the protease of the invention.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: March 30, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Helle Outtrup, Lars Sparre Conrad
  • Patent number: 5885950
    Abstract: A composition and methods for cleaning grease-traps, septic tank control, discharge water from industrial meat and poultry processing and packing plants, lift stations and municipal systems. The composition comprises preservatives at a concentration of about 0.35%, by weight, a non-ionic surfactant at a concentration of about 8%, by weight, triethanolamine at a concentration of about 2%, by weight and a fermentation supernatant at a concentration of about 12.14%, by weight. In a preferred embodiment of the present invention the composition comprises a fermentation supernatant from a Saccharomyces cerevisiae culture, sodium benzoate, imidazolidinyl urea, diazolidinyl urea, triethanolamine and a polyoxyethlene alcohol surfactant.
    Type: Grant
    Filed: January 28, 1997
    Date of Patent: March 23, 1999
    Assignee: Neozyme International, Inc.
    Inventors: Parker Dale, John E. Hill
  • Patent number: 5883064
    Abstract: A granular detergent composition having a density from 550 to 950 g/liter, said detergent composition comprisingi) a polymeric dye transfer inhibiting agentii) a protease having an isoelectric point below 10iii) a surfactant system which is free of alkylbenzene sulfonate surfactant.
    Type: Grant
    Filed: May 24, 1996
    Date of Patent: March 16, 1999
    Assignee: The Procter & Gamble Company
    Inventors: Andre Cesar Baeck, Alfred Busch, Ann Katrien Marie Verschuere
  • Patent number: 5879920
    Abstract: A granular enzyme composition is produced having reduced tendency to form dust and leave a residue, and improved stability and delayed release characteristics. The composition has a core, optionally coated with a vinyl polymer, a layer containing an enzyme and a vinyl polymer and optionally a plasticizer or anti-agglomeration agent, and an outer coating containing a polymer and optionally a low residue pigment and/or lubricant. Preferably, the core is a salt or sugar nonpareil, the vinyl polymer coating the core is polyvinyl alcohol and most preferably partially hydrolyzed polyvinyl alcohol, the vinyl polymer in the enzyme layer is polyvinyl pyrrolidone, and the polymer of the outer coating is polyvinyl pyrrolidone, polyvinyl alcohol which may be partially hydrolyzed, polyethylene glycol or mixtures thereof such as a mixture of polyvinyl pyrrolidone and polyvinyl alcohol or a mixture of polyvinyl pyrrolidone and polyethylene glycol.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: March 9, 1999
    Assignee: Genencor International, Inc.
    Inventors: Douglas A. Dale, Alfred L. Gaertner, Gene Park, Nathaniel T. Becker
  • Patent number: 5880080
    Abstract: The use of alkaline bacillus proteases in commercial laundry methods and compositions containing these proteases for commercial laundering are described.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: March 9, 1999
    Assignee: Solvay Enzymes GmbH & Co. KG
    Inventors: Antoine Amory, Andre Clippe, Gerhard Konieczny-Janda
  • Patent number: 5877139
    Abstract: There is provided an enzymatic detergent composition comprising one or more surfactants and an endoglucanase which is not a Family 7 cellulase, which contains no cellulose binding domain and wherein the catalytic domain contains at least two disulphide bridges. Preferably, the endoglucanase is producible from Thermomonospora fusca, or mutants or variants thereof.
    Type: Grant
    Filed: November 20, 1996
    Date of Patent: March 2, 1999
    Assignee: Lever Brothers Company, Division of Conopco, Inc.
    Inventors: Eric Casteleijn, Willem R. van Dijk, Jan Klugkist, Pieter Dirk van Wassenaar
  • Patent number: 5872091
    Abstract: This invention relates to a laundry detergent composition as well as a method of laundrying fabric or soiled garments in which the composition requires a surfactant, a pectinase enzyme, a specific hemicellulase enzyme or enzymes, a cellulase enzyme, and additional component which includes bleaching agents, builders, an amylase enzyme and/or a protease enzyme.
    Type: Grant
    Filed: January 30, 1997
    Date of Patent: February 16, 1999
    Assignee: Genencor International Inc.
    Inventors: Roelck A. Cuperus, Margareta A. Herweijer, Albert J.J. Van Ooijen, Dick J. Van Schouwen
  • Patent number: 5871550
    Abstract: A mutant cellulase obtainable from Thermomonospora spp is provided which differs from a precursor cellulase in that it has been genetically engineered to introduce a substitution, deletion or addition of an amino acid residue to said precursor cellulase which provided improved activity in a detergent. Preferably, the substitution is at a residue corresponding to T140 in Thermomonospora fusca.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: February 16, 1999
    Assignee: Genencor International, Inc.
    Inventors: Frits Goedegebuur, Scott D. Power, Deborah Winetzky, Anita Van Kimmenade, Mee-Young Yoon
  • Patent number: 5868868
    Abstract: The invention discloses PEG-modified proteases, compositions containing these modified enzymes, and methods for using them to clean contact lenses. The methods of the present invention are also directed to the simultaneous cleaning and disinfecting of contact lenses, when compositions of the present invention are combined with a suitable disinfectant.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: February 9, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Joonsup Park, Ronald P. Quintana, Bor-shyue Hong, Bahram Asgharian
  • Patent number: 5866526
    Abstract: An enzyme preparation comprising a modified enzyme selected from the group consisting of an amylase, lipase, oxidorcductase, pectinace or hemicellulase, the modified enzyme having an improved performance due to an alkaline pI and/or increased surface activity obtained by chemical modification or amino acid substitution, is useful e.g., in detergents, in baking flour, in animal feed, in the manufacture of cellulosic fabrics and for the treatment of lignocellulosic fibers.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: February 2, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Arne Agerlin Olsen, Allan Svendsen, Kim Borch, Henrik Lund, Marianne Thellersen, Peter Rosholm, Niels Munk