Ketone Or Aldehyde Containing Patents (Class 514/125)
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Patent number: 11786483Abstract: Radiation therapy or chemotherapy may cause oral mucositis. Compositions and methods are disclosed here which prevent and/or treat oral mucositis caused by radiation therapy or chemotherapy. The compositions are also effective in treating a number of skin disorders.Type: GrantFiled: March 9, 2020Date of Patent: October 17, 2023Assignee: PATHWAYS BIOSCIENCE, LLCInventors: Brooks Michael Hybertson, Joe Milton McCord
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Patent number: 11446314Abstract: This invention pertains to pharmaceutical compositions comprising a glucocorticoid for use in the treatment of diseases by immunoablation. The compositions of the invention may be for use in the treatment of diseases that are mediated by immune cells such as lymphocytes.Type: GrantFiled: December 20, 2018Date of Patent: September 20, 2022Assignee: AVM Biotechnology, LLCInventor: Theresa Deisher
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Patent number: 10744144Abstract: Disclosed are aqueous pharmaceutical compositions which provide sustained released delivery of corticosteroid compounds. The pharmaceutical composition comprises an insoluble corticosteroid; a soluble corticosteroid; and at least one viscosity enhancing agent. Also provided are methods for using the pharmaceutical compositions in an epidural injection, intra-articular injection, intra-lesional injection, or an intra-ocular injection.Type: GrantFiled: October 30, 2017Date of Patent: August 18, 2020Assignee: Semnur Pharmaceuticals, Inc.Inventor: Mahendra G. Shah
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Patent number: 10556853Abstract: The present application relates to compounds and methods for reducing the severity of convulsant activity or epileptic seizures, or for the treatment of chronic or acute pain.Type: GrantFiled: January 10, 2018Date of Patent: February 11, 2020Assignee: OWEN-BARRY PHARMACEUTICALS INC.Inventors: Michael Poulter, Tony Durst
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Patent number: 9572890Abstract: Provided are stable liquid and solid formulations of oxidized and reduced mitochondria-targeted antioxidants, and methods of their preparation and use.Type: GrantFiled: October 20, 2015Date of Patent: February 21, 2017Assignee: MITOTECH SAInventors: Maxim V. Skulachev, Vladimir P. Skulachev, Audrey A. Zamyatnin, Vadim N. Tashlitsky, Roman A. Zinovkin, Maxim V. Egorov, Lawrence T. Friedhoff, Olga Y. Pletushkina, Alexander A. Andreev-Andrievsky, Tatiana V. Zinevich
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Patent number: 9370496Abstract: The present invention relates to methods of treating Leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones, including alpha-tocotrienol quinone, in order to alleviate symptoms of the disease.Type: GrantFiled: April 9, 2013Date of Patent: June 21, 2016Assignee: EDISON PHARMACEUTICALS, INC.Inventor: Guy M. Miller
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Patent number: 9328128Abstract: The present invention is directed to fluorophosphates, and pharmaceutical compositions thereof, which are inhibitors of intestinal apical sodium/phosphate co-transport and are useful in the treatment of hyperphosphatemia, in reducing blood phosphate levels, and in treating hypertension.Type: GrantFiled: November 25, 2014Date of Patent: May 3, 2016Assignee: DuophosInventors: Brian Peerce, Larry Slomowitz
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Patent number: 9192676Abstract: Provided are stable liquid and solid formulations of oxidized and reduced mitochondria-targeted antioxidants, and methods of their preparation and use.Type: GrantFiled: June 4, 2012Date of Patent: November 24, 2015Assignee: MITOTECH SAInventors: Maxim V. Skulachev, Vladimir P. Skulachev, Andrey A. Zamyatnin, Eugeny S. Efremov, Innokentiy V. Skulachev, Vadim N. Tashlitsky, Roman A. Zinovkin, Maxim V. Egorov, Lawrence T. Friedhoff, Olga Y. Pletushkina, Alexander A. Andreev-Andrievsky, Tatiana V. Zinevich
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Publication number: 20150025043Abstract: Provided are stable liquid and solid formulations of oxidized and reduced mitochondria-targeted antioxidants, and methods of their preparation and use.Type: ApplicationFiled: June 4, 2012Publication date: January 22, 2015Applicant: Mitotech SAInventors: Maxim V. Skulachev, Vladimir P. Skulachev, Andrey A. Zamyatnin, Vadim N. Tashlitsky, Roman A. Zinovkin, Maxim V. Egorov, Lawrence T. Friedhoff, Olga Y. Pletushkina, Alexander A. Andreev-Andrievsky, Tatiana V. Zinevich
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Patent number: 8921343Abstract: The present invention is directed to fluorophosphates, and pharmaceutical compositions thereof, which are inhibitors of intestinal apical sodium/phosphate co-transport and are useful in the treatment of hyperphosphatemia, in reducing blood phosphate levels, and in treating hypertension.Type: GrantFiled: March 4, 2011Date of Patent: December 30, 2014Assignee: DuophosInventors: Brian Peerce, Larry Slomowitz
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Publication number: 20140356434Abstract: Disclosed are aqueous pharmaceutical compositions which provide sustained released delivery of corticosteroid compounds. The pharmaceutical composition comprises an insoluble corticosteroid; a soluble corticosteroid; and at least one viscosity enhancing agent. Also provided are methods for using the pharmaceutical compositions in an epidural injection, intra-articular injection, intra-lesional injection, or an intra-ocular injection.Type: ApplicationFiled: January 23, 2014Publication date: December 4, 2014Applicant: SEMNUR PHARMACEUTICALS, INC.Inventor: Mahendra G. SHAH
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Publication number: 20140329776Abstract: A method for providing to a mammal a neuroprotective effect against a brain pathology that is associated with reactive oxygen species originating from mitochondria (mROS). The method includes the step of administering to the mammal an SkQ mitochondria-targeted antioxidant in an amount effective to provide said neuroprotective effect. The SkQ mitochondria-targeted antioxidant may be administered either prophylactically or for treatment with respect to brain pathologies other than brain trauma or stroke, and may be administered for treatment of brain trauma or stroke.Type: ApplicationFiled: September 21, 2012Publication date: November 6, 2014Applicant: MITOTECH S.A.Inventors: Maxim Vladimirovich Skulachev, Vladimir Petrovich Skulachev, Maxim Viktorovich Egorov, Fedor Fedorovich Severin, Dmitry Borisovich Zorov, Elena Viktorovna Stelmashuk, Nikolai Konstantinovich Isaev, Nadezhda Anatolievna Kapay
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Publication number: 20140255474Abstract: A pharmaceutical composition for parenteral administration, comprising liposomes composed of non-charged vesicle-forming lipids, optionally including not more than five (5) mole percent of charged vesicle-forming lipids, the liposomes having a selected mean particle diameter in the size range between about 40-200 nm and containing a water soluble corticosteroid for the site-specific treatment of inflammatory disorders, is provided.Type: ApplicationFiled: May 27, 2014Publication date: September 11, 2014Applicant: Enceladus Pharmaceuticals B.V.Inventor: Josbert Maarten Metselaar
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Publication number: 20140228290Abstract: The invention provides compositions and methods to treat cancer with an agent that increases reactive oxygen species (ROS) levels in cancer cell mitochondria (“an XTPP agent”) or a pharmaceutically acceptable salt thereof, an inhibitor of hydroperoxide metabolism and a pharmaceutically acceptable diluent or carrier.Type: ApplicationFiled: August 2, 2012Publication date: August 14, 2014Applicants: REGENTS OF THE UNIVERSITY OF MICHIGAN, UNIVERSITY OF IOWA RESEARCH FOUNDATIONInventors: Douglas R. Spitz, Michael K. Schultz, Kyle Kloepping, Yueming Zhu, Nukhet Aykin-Burns, Max S. Wicha
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Publication number: 20140142066Abstract: The present invention relates to pharmacology, medicine, ophthalmology, and, in particular, concerns a class of chemical compounds of structure (I) and also their solvates, isomers or prodrugs applicable when incorporated into pharmaceutical compositions also containing pharmaceutically acceptable carrier which can be useful for prophylaxis and treatment of different eye pathologies such as cataract and macular dystrophy.Type: ApplicationFiled: January 24, 2014Publication date: May 22, 2014Applicant: MITOTECH SAInventors: Vladimir P. SKULACHEV, Maxim V. Skulachev
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Publication number: 20140044692Abstract: Some aspects of the invention provide for a method of treating Impaired Energy Processing Disorders and Mitochondrial Deficiencies using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.Type: ApplicationFiled: April 24, 2012Publication date: February 13, 2014Applicant: RETROTOPE, INC.Inventor: Mikhail S. Shchepinov
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Publication number: 20140044693Abstract: Some aspects of the invention provide for a method of treating Wet and/or Dry Age-related Macular Degeneration, Retinitis Pigmentosa, Diabetic Retinopathy, cataracts, and/or Stargardt Disease using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.Type: ApplicationFiled: April 24, 2012Publication date: February 13, 2014Applicant: RETROTOPE, INC.Inventor: Mikhail S. Shchepnov
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Publication number: 20130338115Abstract: The invention relates to pharmacology and medicine, in particular to a class of mitochondrially-addressed compounds which can be used in the pharmaceutical compositions of medicinal agents (preparations) for preventing and treating cardiovascular diseases and diseases and pathological conditions caused by disturbed blood circulation or oxygen supply to tissues and organs.Type: ApplicationFiled: July 25, 2013Publication date: December 19, 2013Applicant: Mitotech SAInventors: Maxim V. Skulachev, Vladimir P. Skulachev
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Patent number: 8518915Abstract: The invention relates to pharmacology and medicine, in particular to a class of mitochondrially-addressed compounds which can be used in the pharmaceutical compositions of medicinal agents (preparations) for preventing and treating cardiovascular diseases and diseases and pathological conditions caused by disturbed blood circulation or oxygen supply to tissues and organs.Type: GrantFiled: June 29, 2007Date of Patent: August 27, 2013Assignee: Mitotech SAInventors: Maxim Vladimirovich Skulachev, Vladimir Petrovich Skulachev
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Publication number: 20130072463Abstract: Disclosed is a method of treating a cancer on a mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of a compoundType: ApplicationFiled: November 12, 2012Publication date: March 21, 2013Applicant: MITOTECH SAInventor: Mitotech SA
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Publication number: 20130059822Abstract: The present invention is directed to fluorophosphates, and pharmaceutical compositions thereof, which are inhibitors of intestinal apical sodium/phosphate co-transport and are useful in the treatment of hyperphosphatemia, in reducing blood phosphate levels, and in treating hypertension.Type: ApplicationFiled: March 4, 2011Publication date: March 7, 2013Applicant: DUOPHOSInventors: Brian Peerce, Slomowitz Larry
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Publication number: 20120294900Abstract: Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms.Type: ApplicationFiled: March 26, 2012Publication date: November 22, 2012Applicant: UNIVERSITY OF MARYLAND, COLLEGE PARKInventors: Herman Sintim, William E. Bentley, Varnika Roy, Jacqueline Smith
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Publication number: 20120283221Abstract: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.Type: ApplicationFiled: July 17, 2012Publication date: November 8, 2012Inventors: Michael N. Greco, Harold R. Almond, JR., Lawrence de Garavilla, Michael J. Hawkins, Michael J. Humora, Yun Qian, Donald Gilmore Walker, Sergio Cesco-Cancian, Christopher Norman Nillsen, Mitul N. Patel, Kirk Leonard Sorgi, Eugene Powell
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Publication number: 20120165782Abstract: It is an object of the present inventions to produce a pharmaceutical composition for the iontophoresis wherein a drug stability is excellent, and it is easy to blend and fill up when manufactured and it is possible to manufacture at low cost. A pharmaceutical composition for an iontophoresis according to the present invention, is characterized in that the composition contains a nonionic synthetic polymer, betamethasone sodium phosphate and solvent. Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the nonionic synthetic polymer is polyvinyl alcohol (PVA). Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the mixing amount of the polyvinyl alcohol (PVA) is 0.5 to 30.0 percent by weight.Type: ApplicationFiled: July 28, 2010Publication date: June 28, 2012Applicant: TEIKOKU SEIYAKU CO., LTD.Inventors: Akihiro Hasui, Takamitsu Miyagi
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Publication number: 20120094962Abstract: The invention relates to the manufacturing and use of pharmaceutical compositions of medicines (ophthalmic preparations) comprising a mitochondria-addressed antioxidant and a set of auxiliary substances providing effective treatment for ophtalmological diseases in humans and animals.Type: ApplicationFiled: December 9, 2011Publication date: April 19, 2012Applicant: MITOTECH SAInventor: Maxim V. Skulachev
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Publication number: 20120046247Abstract: This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.Type: ApplicationFiled: August 16, 2011Publication date: February 23, 2012Inventors: Charles C-Y Shih, Toshio Kitamura, Qian Shi, Toshiyuki Kawashima, Hui-Kang Wang
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Publication number: 20110311503Abstract: The novel active ingredient combinations which consist of the compounds of the formula (I) in combination with further active insecticidal ingredients (II) are very suitable for control of animal pests such as insects and/or unwanted acarids.Type: ApplicationFiled: June 16, 2011Publication date: December 22, 2011Applicant: BAYER CROPSCIENCE AGInventors: Christian FUNKE, Heike HUNGENBERG, Rüdiger FISCHER
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Publication number: 20110288055Abstract: This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms, uses and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.Type: ApplicationFiled: January 5, 2011Publication date: November 24, 2011Inventors: Kenneth Martin Taylor, Robin A.J. Smith
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Patent number: 8022101Abstract: A method of treatment of native, non-denatured tissue to increase resistance to tearing, fissuring, rupturing, and/or delamination, comprising the step of: contacting at least a portion of the tissue with an effective amount of a reagent that increases crosslinks in the tissue.Type: GrantFiled: February 28, 2007Date of Patent: September 20, 2011Assignee: Orthopeutics, L.P.Inventor: Thomas P. Hedman
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Publication number: 20110053895Abstract: The invention relates to pharmacology and medicine, in particular to a class of mitochondrially-addressed compounds which can be used in the pharmaceutical compositions of medicinal agents (preparations) for preventing and treating cardiovascular diseases and diseases and pathological conditions caused by disturbed blood circulation or oxygen supply to tissues and organs.Type: ApplicationFiled: June 29, 2007Publication date: March 3, 2011Inventors: Maxim Vladimirovich Skulachev, Vladimir Petrovich Skulachev
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Patent number: 7888335Abstract: This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms, uses and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.Type: GrantFiled: August 23, 2004Date of Patent: February 15, 2011Assignee: Antipodean Pharmaceuticals, Inc.Inventors: Kenneth Martin Taylor, Robin A. J. Smith
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Publication number: 20100323992Abstract: The present invention relates to pharmacology, medicine, opthalmology, and, in particular, concerns a class of chemical compounds of structure (I) and also their solvates, isomers or prodrugs applicable when incorporated into pharmaceutical compositions also containing pharmaceutically acceptable carrier which can be useful for prophylaxis and treatment of different eye pathologies such as cataract and macular dystrophy.Type: ApplicationFiled: October 20, 2006Publication date: December 23, 2010Inventors: Vladimir P. Skulachev, Maxim V. Skulachev
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Publication number: 20100323887Abstract: Disclosed are compounds of Formula 1, wherein X is O or S; Y is O or S; and R1, R2, R3 and R4 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.Type: ApplicationFiled: January 30, 2009Publication date: December 23, 2010Applicant: E.I. DU Pont De Nemours and CompanyInventors: Caleb William Holyoke, JR., My-Hanh Thi Tong, Reed Aaron Coats, Wenming Zhang, Stephen Frederick McCann, Dominic Ming-Tak Chan
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Publication number: 20100311677Abstract: The novel active compound combinations comprising compounds of the formulae (I) and (II) have very good insecticidal and acaricidal properties.Type: ApplicationFiled: September 9, 2008Publication date: December 9, 2010Applicant: Bayer CropScience AGInventors: Reiner Fischer, Wolfram Andersch, Heike Hungenberg
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Publication number: 20100297262Abstract: Described herein are pharmaceutical compositions and medicaments, and methods of using such pharmaceutical compositions and medicaments in the treatment of inflammation and cancer.Type: ApplicationFiled: April 16, 2010Publication date: November 25, 2010Applicant: COLBY PHARMACEUTICAL COMPANYInventors: Hirak S. Basu, David A. Zarling
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PHARMACEUTICAL AND COSMETIC COMPOSITIONS FOR ACCELERATED HEALING OF WOUNDS AND OTHER SURFACE DAMAGES
Publication number: 20100292625Abstract: The invention relates to biology and medicine, in particular, it can be used in medicine for preparing a pharmacological composition used for accelerated healing of wounds and the damages by means of addressed (directed) delivery of biologically active agents to mitochondria by means electrochemical potential of hydrogen ions contained therein. Said invention can be also used for producing a composition useful in transplantation surgery for preserving transplantation material and for inhibiting rejection. Moreover, the invention can be used for producing a cosmetic agent for improving state of the skin and for the revitalisation and regeneration thereof.Type: ApplicationFiled: January 29, 2007Publication date: November 18, 2010Inventors: Vladimir P. Skulachev, Maxim V. Skulachev -
Publication number: 20100234326Abstract: The invention relates to pharmacology, medicine and gerontology, in particular to a class of chemical structures (1) which can be used in compositions, in the form of geroprotectors, for extending the life time, decelerating, stopping or for reversing the process of the entirety of the organism's dysfunctions causing the mammal ageing and for preventing and treating particular senile diseases.Type: ApplicationFiled: April 11, 2007Publication date: September 16, 2010Inventors: Maxim V. Skulachev, Vladimir P. Skulachev
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Publication number: 20100144680Abstract: The invention relates to pharmacology, medicine and oncology, in particular, to a class of chemical compounds, the structure of which corresponds to formula (I) and which can be used in pharmaceutical compositions for preventing and treating an extended range of oncological diseases, including, in the form of an anti-tumoral preparation and a preparation which is used for combined therapy of oncological diseases.Type: ApplicationFiled: January 29, 2007Publication date: June 10, 2010Applicant: LIMITED LIABILITY COMPANY "MITOTECHNOLOGY"Inventors: Vladimir P. Skulachev, Maxim V. Skulachev
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Publication number: 20090291924Abstract: The present invention relates to a computer-assisted method of a designing of a tubulin inhibitor comprising: a) determining an interaction between a tubulin protein and a chemical known to bind the tubulin protein by evaluating a binding of the tubulin protein to the chemical known to bind the tubulin protein; b) based on the interaction, designing a candidate tubulin inhibitor; c) determining an interaction between the tubulin protein and the candidate tubulin inhibitor by evaluating a binding of the tubulin protein to the candidate tubulin inhibitor; and d) concluding that the candidate tubulin inhibitor inhibits the tubulin protein wherein the conclusion is based on the interaction of step c). The invention also provides compositions and methods of treatment of diseases with the candidate tubulin inhibitors.Type: ApplicationFiled: May 21, 2009Publication date: November 26, 2009Applicant: BiPar Sciences, Inc.Inventors: Valeria Ossovskaya, John Burnier, Barry Sherman, Max Totrov
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Publication number: 20090258841Abstract: Compositions and methods are for disclosed for treating a skin condition that results from reactive oxygen species production in skin of a subject, including applying a topical formulation that contains a lipophilic cation-mitochondrially targeted antioxidant compound and that delivers a therapeutically effective amount of the antioxidant compound to skin fibroblasts and keratinocytes.Type: ApplicationFiled: March 24, 2009Publication date: October 15, 2009Inventors: Michael Patrick Murphy, Robin A.J. Smith, Kenneth Martin Taylor
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Publication number: 20090137393Abstract: The invention relates to novel 2,4,6-trialkylphenyl-substituted cyclopentane-1,3-diones of the formula (I) in which X, Y, A, B, Q1, Q2 and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising, firstly, the 2,4,6-trialkylphenyl-substituted cyclopentane-1,3-diones of the formula (I) and, secondly, at least one crop plant compatibility-improving compound.Type: ApplicationFiled: January 3, 2007Publication date: May 28, 2009Applicant: Bayer CropScience AGInventors: Reiner Fischer, Stefan Lehr, Dieter Feucht, Ulrich Gorgens, Olga Malsam, Alfred Angermann, Guido Bojack, Alan Graff, Christian Arnold, Thomas Auler, Martin Jeffrey Hills, Hein Kehne, Christopher Hugh Rosinger, Jan Dittgen
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Publication number: 20090130156Abstract: The present invention relates to a new formulation characterised by the presence of two components, one of which (A) possesses insecticidal, acaricidal, fungicidal, snailcidal or vermicidal activity and the other (B) exhibits synergistic activity with the first by enhancing its effectiveness, and in which the average release time of component (A) is 1 to 12 hours later than the average release time of component (B). The formulation is obtained by: a) separate microencapsulation of both components (A) and (B) within a multilayer system of specific polymers in which component (A) is in a more interior portion of the capsule than component (B), being separated from component (B) by a polymer layer of suitable thickness (FIG. 1); b) microencapsulation of both components within a single layer system (FIG. 2), combined with an immediate-release emulsion/microemulsion containing an additional amount of component (B).Type: ApplicationFiled: April 20, 2006Publication date: May 21, 2009Applicant: ENDURA S.P.A.Inventors: Valerio Borzatta, Oreste Picolo, Elisa Capparella
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Patent number: 7470821Abstract: The invention relates to novel aldolase-inhibiting compounds that can be advantageously used as medicaments (in therapeutic doses), especially for treating certain cancers, due to the inhibition efficacy thereof. An inventive compound corresponds to general formula (I) wherein the aldehyde group (—CHO) and the phenol group (—OH) are linked to two carbon atoms adjacent to the same aromatic chain, i.e., the first aromatic chain, and R is a phosphate group or a phosphate group mimetic linked to a carbon atom of the second aromatic chain.Type: GrantFiled: June 29, 2004Date of Patent: December 30, 2008Assignees: Valorisation-Recherche, Limited Partnership, Universite Paul Sabatier Toulouse IIIInventors: Chantal Dax, Casimir Blonski, Laurent Azema, Jurgen Sygusch
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Publication number: 20080311183Abstract: The present invention relates to compounds for the inhibition of pyruvate kinase and ATP production which are capable of inhibiting cancer cells proliferation.Type: ApplicationFiled: May 29, 2006Publication date: December 18, 2008Inventors: Brian R. Smith, Tak-Hang Chan, Brian Leyland-Jones
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Publication number: 20080161267Abstract: This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms, uses and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.Type: ApplicationFiled: August 23, 2004Publication date: July 3, 2008Applicant: Antipodean Pharmaceuticals, Inc.Inventors: Kenneth Martin Taylor, Robin A.J. Smith
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Publication number: 20080119441Abstract: This invention related to a series of new phosphonic acid derivatives having anti-hyperphosphatemia activity. (I) [wherein: A is selected from —(CH2)n—, —CO—, —(CH2)n—CO—(CH2)m—, —(CH2)n—CS—(CH2)m— or branched alkylene group. B ring and C ring are selected from benzene ring, naphthalene ring, azulene ring or, heterocycle or fused heterocycle. D is —(CH2)(n+1)—, —(CH2)-O—(CH2)m—, —(CH2)—S(O)o—(CH2)m—, —CF3 or —(CH2)n—NR10—(CH2)m— (wherein: D ring is connected with the carbon atom composing C ring.) E is selected from oxygen atom or sulfur atom. P is phosphine atom. R1˜R7 (wherein R1 and R2, R4 and R5 are joined together with neighbored carbon atom to form 5˜7 membered saturated or unsaturated hydrocarbon ring, or 5˜6 membered fused heterocycle. R1, R2 and R3 are not hydrogen atom if B ring is benzene ring.) may be the same or different and are substituents. R8 and R9 are may be the same or different and are substituents. R10 is alkyl group. n and m are 0-10. o is 0-2.Type: ApplicationFiled: October 5, 2005Publication date: May 22, 2008Inventors: Hiroshi Tomiyama, Masayuki Yokota, Kazuo Tokuzaki, Ryoko Tomita
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Patent number: 7238659Abstract: Reduced degeneration of an axon predetermined to be subject to degenerative neuropathy in a term patient is effected by contacting the axon in situ with an effective amount of a ubiquitin-proteasome system (UPS) inhibitor sufficient to reduce degeneration of the axon; and detecting a resultant reduction in the degeneration of the axon in situ.Type: GrantFiled: November 19, 2005Date of Patent: July 3, 2007Assignees: Children's Medical Center Corporation, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Zhigang He, Qiwei Zhai, Jing Wang, Ryan Watts, Eric Hoopfer, Liqun Luo
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Patent number: 7012063Abstract: Reduced degeneration of an axon predetermined to be subject to degenerative neuropathy in a term patient is effected by contacting the axon in situ with an effective amount of a ubiquitin-proteasome system (UPS) inhibitor sufficient to reduce degeneration of the axon; and detecting a resultant reduction in the degeneration of the axon in situ.Type: GrantFiled: June 13, 2003Date of Patent: March 14, 2006Assignee: Children's Medical Center CorporationInventors: Zhigang He, Qiwei Zhai, Jing Wang, Ryan Watts, Eric Hoopfer, Liqun Luo
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Patent number: 6919322Abstract: Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.Type: GrantFiled: March 7, 2001Date of Patent: July 19, 2005Assignee: Metabasis Therapeutics, Inc.Inventors: Brett C. Bookser, Qun Dang, K. Raja Reddy
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Publication number: 20040224926Abstract: A method for inhibiting or blocking molecular generating and/or inducing functions of molecules using an inhibitory or blocking agent of the formula: 1Type: ApplicationFiled: November 24, 2003Publication date: November 11, 2004Inventors: Shozo Koyama, Yoshihiro Yamaguchi