Nitrogen Bonded Directly To Phosphorus Patents (Class 514/137)
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Patent number: 6214809Abstract: A method of treating or preventing supraventricular tachyarrhythmias is disclosed which comprises the use of a compound which selectively blocks the ultra-rapidly-activating delayed rectifier K+ current (IKur) of the human atrium.Type: GrantFiled: April 19, 1999Date of Patent: April 10, 2001Assignee: Merck & Co., Inc.Inventors: Bernard Fermini, Joseph J. Lynch, Jr., Joseph J. Salata, Richard J. Swanson
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Patent number: 6207171Abstract: A soluble polyphosphazene polyelectrolyte immunoadjuvant is disclosed. In one embodiment, the polymeric adjuvant is poly[di(carboxylatrophenoxy)phosphazene] which is in the form of a microsphere and which is adsorbed with antigen after formation of the microsphere. The immunoadjuvant can be administered intranasally.Type: GrantFiled: March 25, 1999Date of Patent: March 27, 2001Assignee: Avant Immunotherapeutics, Inc.Inventors: Lendon G. Payne, Angela L. Woods, Sharon A. Jenkins
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Patent number: 6040299Abstract: There is disclosed a cold storage stabilized organophosphorus insecticide formulation. The formulation comprises a solid carrier and between approximately 2% and 40% by weight of the ultimate formulation of a nominally solid organophosphorus insecticide and between approximately 0.5% and 10% by weight of the ultimate formulation of a stabilizer compound selected from cyclohexanone and N-methylpyrrolidone. A method of making the cold storage stabilized organophosphorus insecticide formulation is also disclosed.Type: GrantFiled: October 23, 1998Date of Patent: March 21, 2000Assignee: Griffin LLCInventor: Hamid Ullah
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Patent number: 6017905Abstract: The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, ##STR1## wherein Ar and Ar.sup.1 are each independently selected from unsubstituted or substituted phenyl which substituents are from 1-5 in number and are each independently selected from alkyl, alkoxy, hydroxy, halogen, nitro, trifluoromethyl, COOH, and COOalkyl;X is --NH--, --O--, --S--, or --(CH.sub.2).sub.0-4 --, andR is hydrogen, alkyl, or phenyl.Type: GrantFiled: June 9, 1998Date of Patent: January 25, 2000Assignee: Warner-Lambert CompanyInventors: William Howard Roark, Bruce David Roth
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Patent number: 6015563Abstract: A polyphosphazene polyelectrolyte immunoadjuvant having improved water solubility, a vaccine composition of the immunoadjuvant and an antigen or immunogen and methods of their use in producing or enhancing an immunoprotective response in a host are disclosed.Type: GrantFiled: November 4, 1998Date of Patent: January 18, 2000Assignee: AVANT Immunotherapeutics, Inc.Inventors: Alexander K. Andrianov, Lendon G. Payne, Jonathan R. Sargent, Sameer S. Sule
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Patent number: 5994331Abstract: The present invention relates to insecticidal mixtures of chloronicotinyl insecticides of the formula (I) ##STR1## in which R.sup.1 represents C.sub.1 -C.sub.5 -alkyl,R.sup.2 represents hydrogen or C.sub.1 -C.sub.5 -alkyl,orR.sup.1 and R.sup.2 together represent --CH.sub.2 --CH.sub.2 --; --CH.sub.2 --CH.sub.2 --CH.sub.2 -- or ##STR2## X represents an NH group, NCH.sub.3 group or represents sulphur, Y represents nitrogen or a CH group andZ represents cyano or nitro,with one or more of the synergists mentioned in the description.Type: GrantFiled: November 17, 1997Date of Patent: November 30, 1999Assignee: Bayer AtiengesellschaftInventors: Christoph Erdelen, Wolfgang Kramer, Kai-Uwe Bruggen
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Patent number: 5922698Abstract: The invention relates to a pesticidal formulation having systemic activity and intended for application to a stem of a plant, which includes the compound methamidophos as an active ingredient, a suitable solvent for the active ingredient, and a colorant selected to impart an identifiable coloration to the formulation for a predetermined period of time related to the duration of the residual activity of the active ingredient. The solvent is preferably a non-volatile organic solvent selected for its low phytotoxicity and its low toxicity for humans, such as an aryl ethoxylate or a polyhydric alcohol. The colorant is preferably selected on the basis of its water solubility, having a limited solubility in water to be eluted gradually from the formulation over a period of time selected to coincide with the duration of the residual activity of the active ingredient. The formulation advantageously also includes an ingredient capable of screening ultra violet rays of the sun.Type: GrantFiled: July 12, 1994Date of Patent: July 13, 1999Assignee: Gouws & Scheepers (Proprietary) LimitedInventors: Martin David Bloomberg, Coenraad Jacobus Beukes Scholtz, Ian Francois Brink
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Patent number: 5855895Abstract: A polyphosphazene polyelectrolyte immunoadjuvant having improved water solubility, a vaccine composition of the immunoadjuvant and an antigen or immunogen and methods of their use in producing or enhancing an immunoprotective response in a host are disclosed.Type: GrantFiled: June 7, 1995Date of Patent: January 5, 1999Assignee: Virus Research InstituteInventors: Alexander K. Andrianov, Lendon G. Payne, Jonathan R. Sargent, Sameer S. Sule
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Patent number: 5840917Abstract: A phosphorylamide derivative represented by the general formula (I): ##STR1## wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.Type: GrantFiled: December 6, 1996Date of Patent: November 24, 1998Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoru Oi, Hideaki Nagaya, Nobuhiro Inatomi, Masafumi Nakao, Hidefumi Yukimasa
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Patent number: 5798346Abstract: The invention relates to a pesticidal formulation having systemic activity and intended for application to a stem of a plant, which includes the compound methamidophos as an active ingredient, a suitable solvent for the active ingredient, and a colorant selected to impart an identifiable coloration to the formulation for a predeterminable period of time related to the duration of the residual activity of the active ingredient. The solvent is preferably a non-volatile organic solvent selected for its low phytotoxicity and its low toxicity for humans, such as an aryl ethoxylate or a polyhydric alcohol. The colorant is preferably selected on the basis of its water solubility, having a limited solubility in water to be eluted gradually from the formulation over a period of time selected to coincide with the duration of the residual activity of the active ingredient. The formulation advantageously also includes an ingredient capable of screening ultra violet rays of the sun.Type: GrantFiled: July 12, 1994Date of Patent: August 25, 1998Assignee: Gouws & Scheepers (Proprietary) LimitedInventors: Martin David Bloomberg, Coenraad Jacobus Beukes Scholtz, Ian Francois Brink
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Patent number: 5712261Abstract: A method is provided for preventing and/or treating hypertriglyceridemia, and/or atherosclerosis and/or pancreatitis resulting from hypertriglyceridemia, employing a squalene synthetase inhibitor.Type: GrantFiled: June 21, 1995Date of Patent: January 27, 1998Inventors: David R. Magnin, Scott A. Biller, John K. Dickson, Jr., R. Michael Lawrence, Richard B. Sulsky
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Patent number: 5709890Abstract: An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or salt form thereof such as polyaspartic acid, particularly preferred with a molecular weight in the range of about 3000 to 40,000.Type: GrantFiled: March 20, 1997Date of Patent: January 20, 1998Assignee: Donlar CorporationInventor: J. Larry Sanders
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Patent number: 5693627Abstract: A method of inhibiting the proliferation of B cells by using inhibitors of phosphotyrosine phosphatase can be used to regulate the immune response and to treat diseases such as leukemias or lymphomas marked by malignant proliferation of B cells. The use of such inhibitors can be combined with radiation, which produces a synergistic effect. Several types of inhibitors can be used, including: (1) compounds comprising a metal coordinate-covalently bound to an organic moiety that can form a five- or six-membered ring; (2) compounds in which vanadium (IV) is coordinate-covalently bound to an organic moiety such as a hydroxamate, .alpha.-hydroxypyridinone, .alpha.-hydroxypyrone, .alpha.-amino acid, hydroxycarbonyl, or thiohydroxamate; (3) coordinate-covalent complexes of vanadyl and cysteine or a derivative thereof; (4) nonhydrolyzable phosphotyrosine phosphatase analogues; (5) phostatin; and (6) 4-(fluoromethyl)phenyl phosphate and esterified derivatives.Type: GrantFiled: May 25, 1995Date of Patent: December 2, 1997Assignee: Bristol-Myers Squibb CompanyInventor: Gary L. Schieven
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Patent number: 5659061Abstract: The composition, synthesis, and applications of tumor associated protease activated prodrugs of phosphoramide mustard, isophosphoramide mustard and analogs with detoxification functionalities are described. These drugs release a cytotoxic phosphoramide mustard analog following activation by tumor associated proteases and esterases. The general structure for these drugs is: ##STR1## Wherein R1 is a beta-X-ethyl-amino group which may optionally bear substituents on the nitrogen or carbon atoms; wherein X is a good leaving group such as a halogen; R2 is a beta-X-ethyl-amino group which may optionally bear substituents on the nitrogen or carbon atoms; or an amino group (NH.sub.2) which may optionally be substituted. Wherein A is a benzyloxy derivative with one or more acyloxy or acylamino groups in para or ortho portions relative to the phosphoester; and wherein the acyloxy or acylamino groups are not (substituted or unsubstituted) p-guanidino-benzoyloxy groups or p-guanidino-benzoylamino groups.Type: GrantFiled: April 20, 1995Date of Patent: August 19, 1997Assignee: Drug Innovation & Design, Inc.Inventor: Arnold Glazier
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Patent number: 5646133Abstract: An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or salt form thereof such as polyaspartic acid, particularly preferred with a molecular weight in the range of about 3000 to 40,000.Type: GrantFiled: March 14, 1996Date of Patent: July 8, 1997Assignee: Donlar CorporationInventor: J. Larry Sanders
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Patent number: 5369100Abstract: The present invention is directed to an insecticidal composition including irregularly shaped to spherically shaped particles prepared by compaction, in the absence of a binder, of an admixture including ammonium sulfate and at least one insecticidal compound of the formula: ##STR1## wherein R and R.sup.1 individually are an alkyl, alkenyl or alkynyl group containing up to 6 carbon atoms, R.sup.2 is hydrogen, an alkyl group containing 1 to 18 carbon atoms, a cycloalkyl group containing 3 to 8 carbon atoms, an alkenyl group containing 2 to 18 carbon atoms or an alkynyl group containing 3 to 18 carbon atoms, R.sup.3 is hydrogen or an alkyl group containing 1 to 6 carbon atoms, and Y is oxygen or sulfur. The present invention is also directed to methods for manufacturing such particles and for killing insects with such particles.Type: GrantFiled: September 24, 1992Date of Patent: November 29, 1994Assignee: Valent U.S.A. CorporationInventor: Gary L. Cummings
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Patent number: 5298501Abstract: Chemically stable granular insecticidal compositions of phosphoroamidothioates and phosphoroamidodithioates are provided. These compositions comprise at least 83 weight percent of ammonium sulfate effective for granulating the insecticidal components. Insecticidal methods employing these granules are also disclosed.Type: GrantFiled: February 9, 1993Date of Patent: March 29, 1994Assignee: Valent U.S.A. CorporationInventor: Gary Cummings
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Patent number: 5173482Abstract: Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: ##STR1## and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.Type: GrantFiled: December 6, 1990Date of Patent: December 22, 1992Assignee: Cetus CorporationInventors: Danute E. Nitecki, Margaret Moreland, Lois Aldwin, Corey H. Levenson, Irwin Braude, David F. Mark, Henry Rapoport
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Patent number: 5166144Abstract: The invention relates to new O-halogenocyclobutyl S-alkyl (di)thiophosphoric acid ester-amides of the general formula (I) ##STR1## in which A represents fluorine or chlorine,B represents hydrogen or alkyl,X represents oxygen or sulphur,R.sup.1 represents hydrogen, alkyl, --COH (formyl) or --CO-alkyl (acyl) which is optionally substituted by halogen,R.sup.2 represents hydrogen or alkyl, andR.sup.3 represents alkyl or alkoxyalkyl,which can be used as agents for combating pests.Type: GrantFiled: March 20, 1992Date of Patent: November 24, 1992Assignee: Bayer AktiengesellschaftInventors: Bernd-Wieland Kruger, Dietmar Bielefeldt, Karl-R. Gassen, Jurgen Hartwig, Wilhelm Stendel, Christoph Erdelen
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Patent number: 5164383Abstract: O-Halogenocyclopentyl S-alkyl (di)thiphosphoric(phosphonic) acid ester derivatives of the general formula (I) ##STR1## in which R.sup.1 represents alkyl, alkoxy or the radical ##STR2## R.sup.3 represents hydrogen or alkyl and R.sup.4 represents hydrogen, alkyl, --COH (formyl) or optionally halogen-substituted --CO-alkyl (acyl),R.sup.2 represents alkyl or alkoxyalkyl andX represents oxygen or sulphur,can be used as pesticides.Type: GrantFiled: March 20, 1992Date of Patent: November 17, 1992Assignee: Bayer AktiengesellschaftInventors: Bernd-Wieland Kruger, Michael Negele, Jurgen Hartwig, Christoph Erdelen, Wilhelm Stendel
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Patent number: 4983594Abstract: Pesticidal thionophosphoric acid amide esters of the formula ##STR1## in which R.sup.1 stands for optionally substituted radicals from the group consisting of alkoxy, alkenyloxy and alkinyloxy,R.sup.2 and R.sup.3 are identical or different and independently of one another stand for hydrogen or for optionally substituted radicals from the group consisting of alkyl, cycloalkyl, alkenyl and alkinyl, or together with the nitrogen atom to which they are bonded form a 5- to 7-membered ring, andX stands for halogen.Intermediates of the formulae ##STR2## in which X.sup.1 is halogen, are also new.Type: GrantFiled: March 23, 1989Date of Patent: January 8, 1991Assignee: Bayer AktiengesellschaftInventors: Herbert Sommer, Dieter Arlt, Jurgen Hartwig, Bernhard Homeyer, Hans-Detlef Matthaei
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Patent number: 4965256Abstract: The foregoing invention relates to new soil pest combating agents which contain at least one conventional active agent, especially a carbamate, P-esters (phosphoric and phosphonic acid esters, including esteramides, as well as corresponding thiono-, thiol- and thiono-thiol derivatives) and pyrethroids as well as Flubenzimin.Type: GrantFiled: December 5, 1986Date of Patent: October 23, 1990Assignees: Bayer Aktiengesellschaft, Mobay CorporationInventors: John Anderson, Bernhard Homeyer, Walter M. Zeck
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Patent number: 4965255Abstract: The foregoing invention relates to new soil pest combating agents which can be used in plant protection for combating nematodes and arthropods, especially insects, and which contain at least one conventional active agent, especially a carbamate, P ester (phosphoric and phosphonic acid esters, including esteramides as well as the thiono-, thiol- and thiono-thiol derivatives) or pyrethroid and at least Captan and/or Captofol.Type: GrantFiled: December 5, 1986Date of Patent: October 23, 1990Assignees: Bayer Aktiengesellschaft, Mobay CorporationInventors: John Anderson, Bernhard Homeyer, Walter M. Zeck
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Patent number: 4894368Abstract: Novel triarylphosphinimide derivatives having the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each at the ortho or meta position, represent mono- or disubstituents and are selected from the group consisting of hydrogen, alkyl(C.sub.1 -C.sub.3), alkoxy(C.sub.1 -C.sub.3), trifluoromethyl and halogen; and R.sub.4 is selected from the group consisting of alkyl (C.sub.1 -C.sub.3), alkenyl(C.sub.2 -C.sub.3), alkynyl(C.sub.2 -C.sub.4), alkynyl(C.sub.2 -C.sub.4), cycloalkyl(C.sub.3 -C.sub.5), cycloalkyl(C.sub.3 -C.sub.6)methyl, 4-oxopentyl, 3-tetrahydrofuranyl, 2,3-dihydro-1H-iden-1-yl, 1-alkyl(C.sub.1 -C.sub.3)cyclopentyl, trans-2-alkyl(C.sub.1 -C.sub.3)cyclopentyl, trans-2-alkoxy(C.sub.1 -C.sub.3)cyclopentyl, 1-cyclopropylethyl, 2-methylcyclopropylmethyl, dicyclopropylmethyl, 2-, 3- or 4-pyridinylmethyl, 2-cyclopenten-1-yl, tetrahydro-2H-pyran-4-yl and cis and trans-2-methoxycyclohexyl; with the proviso that when R.sub.4 is alkyl(C.sub.1 -C.sub.3), R.sub.1, R.sub.2 and R.sub.Type: GrantFiled: June 17, 1988Date of Patent: January 16, 1990Assignee: American Cyanamid CompanyInventors: Andrew S. Tomcufcik, John E. Emma, Nancy H. Eudy, Joseph W. Marsico, Howard Newman
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Patent number: 4795640Abstract: A solvent-free oil-in-water emulsion of propetamphos comprising(a) 5 to 50% by weight of technical propetamphos in the form of droplets having a particle size of below 5 micron,(b) 1 to 8% by weight of a polyvinyl alcohol,(c) 1 to 3% by weight of a buffer, buffering the pH of the formulation to pH 6 to 7,(d) 1 to 2% by weight of a vegetable oil,(e) 0.5 to 2% by weight of an emulsifier(f) 0 to 8% by weight of an antifreezing agent(g) 0 to 0.1% by weight of an antifoaming agent (h) 0 to 0.1% by weight of a perfume,the balance being water, and a process of preparing such emulsion.Type: GrantFiled: June 8, 1987Date of Patent: January 3, 1989Assignee: Sandoz Ltd.Inventor: Hans Helfenberger
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Patent number: 4767749Abstract: Novel triarylphosphinimide derivatives having the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each at the ortho or meta position, represent mono- or disubstituents and are selected from the group consisting of hydrogen, alkyl(C.sub.1 -C.sub.3), alkoxy(C.sub.1 -C.sub.3), trifluoromethyl and halogen; and R.sub.4 is selected from the group consisting of alkyl(C.sub.1 -C.sub.3), alkenyl(C.sub.2 -C.sub.3), alkynyl(C.sub.2 -C.sub.4), cycloalkyl(C.sub.3 -C.sub.5), cycloalkyl(C.sub.3 -C.sub.6)methyl, 4-oxopentyl, 3-tetrahydrofuranyl, 2,3-dihydro-1H-inden-1-yl, 1-alkyl(C.sub.1 -C.sub.3)cyclopentyl, trans-2-alkyl(C.sub.1 -C.sub.3)cyclopentyl, trans-2-alkoxy(C.sub.1 -C.sub.3)cyclopentyl, 1-cyclopropylethyl, 2-methylcyclopropylmethyl, dicyclopropylmethyl, 2-, 3- or 4-pyridinylmethyl, 2-cyclopenten-1-yl, tetrahydro-2H-pyran-4-yl and cis and trans-2-methoxycyclohexyl; with the proviso that when R.sub.4 is alkyl(C.sub.1 -C.sub.3), R.sub.1, R.sub.2 and R.sub.3 may not each be hydrogen ##STR2## wherein R.sub.Type: GrantFiled: July 23, 1986Date of Patent: August 30, 1988Assignee: American Cyanamid CompanyInventors: Andrew S. Tomcufcik, John E. Emma, Nancy H. Eudy, Joseph W. Marsico, Howard Newman
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Patent number: 4708869Abstract: A method and composition for causing casualties among mammals by contacting composition comprising casuality producing chemical agents, thickener and open multicellular polymer and said composition covering various external surfaces.Type: GrantFiled: September 2, 1969Date of Patent: November 24, 1987Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Abraham Koblin
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Patent number: 4666767Abstract: Articles of manufacture are disclosed for the controlled delivery of pest controlling substances. Methods for producing such articles and utilizing them in pest control programs are also described. Laminated articles are provided which comprise one or more layers containing active pest control and pest attractant substances and which allow the controlled release of the pest controlling substance from within the laminate to the surface of the laminate so as to maximize efficiency against target species in the surrounding environment. The laminated structure also permits prolonged, controlled release of pest controlling substances and properly timed combinations of such substances that might otherwise be prematurely dissipated, decomposed or inefficiently applied. Various combinations of polymers materials and active agents and a number of different laminated structures are utilized to optimize efficient use of the pest controlling substance against a variety of target species.Type: GrantFiled: September 22, 1981Date of Patent: May 19, 1987Assignee: Herculite Protective Fabrics CorporationInventors: Henry Von Kohorn, Agisa F. Kydonieus
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Patent number: 4656163Abstract: The present invention relates to the use of the sulphenic acid amides of the general formula (I) ##STR1## in which X represents identical or different halogen atoms,Y.sup.1 and Y.sup.2 are identical or different and represent hydrogen, halogen, alkyl, alkoxy, halogenoalkyl or NO.sub.2 andZ represents halogen, --OH, --NHOH or the group --OR.sup.1,in whichR.sup.1 denotes optionally substituted radicals from the series comprising alkyl, alkenyl, alkinyl, cycloalkyl, aryl, aralkyl and heterocyclyl, orZ represents the group ##STR2## in which R.sup.2 and R.sup.3 are identical or different and denote hydrogen or a heterocyclic radical, orZ represents the group --OMin which M denotes ammonium or the equivalent of an alkali metal, alkaline earth metal or heavy metal cation, for prolonging the duration of a high activity in agents for combating soil pests.Type: GrantFiled: November 14, 1985Date of Patent: April 7, 1987Assignees: Bayer Aktiengesellschaft, Mobay CorporationInventors: John Anderson, Bernhard Homeyer, Engelbert Kuhle, Hans Scheinpflug, Walter M. Zeck, Donald E. Simonet
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Patent number: 4614734Abstract: This invention relates to phosphoroamidothioate and phosphoroamidodithioate compounds, to compositions thereof which are useful as pesticides, for example, as athropodicides (that is, insecticides and acaricides), nematocides, and fungicides, and to a method of controlling pests, such as insects, acarids, nematodes, and fungi. The compounds of the invention are effective against soil insects, especially the corn rootworm, when applied by soil application techniques and are also effective when applied to agricultural plants and other plants by foliar application techniques.Type: GrantFiled: June 25, 1984Date of Patent: September 30, 1986Assignee: Rohm and Haas CompanyInventors: Joel R. Smolanoff, J. Michael Fitzpatrick, Janet Ollinger
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Patent number: 4568669Abstract: Cyclopropyl-methyl-(thio)-phosphoric acid amides of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and X have the meanings given in the claims and description, a process for their preparation and their use as pest control agents.Type: GrantFiled: September 29, 1983Date of Patent: February 4, 1986Assignee: BASF AktiengesellschaftInventors: Rainer Burstinghaus, Karl Kiehs, Heinrich Adolphi