Bactericidal/permeability-increasing (bpi) Protein Affecting Or Utilizing Patents (Class 514/2.2)
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Patent number: 11123400Abstract: The present invention relates to a broken or kinked helical peptide or peptide analogue and the use thereof, and more particularly to a Gram-negative bacterial membrane-penetrating peptide or peptide analogue wherein an alpha-helical amphipathic peptide composed of hydrophobic amino acids and hydrophilic amino acids has a kinked structure, or an antimicrobial composition employing the specific activity of the peptide against the Gram-negative bacterial membrane, or an antimicrobial composition for co-administration, or a conjugate comprising a drug linked to the peptide or peptide analogue, or an antibiotic comprising the same.Type: GrantFiled: September 19, 2016Date of Patent: September 21, 2021Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATIONInventors: Jaehoon Yu, Yan Lee, Soonsil Hyun, Seo Yeon Kim, Sun Mi Jin, Yunhwa Choi, Doyeon Jo, Seonju Lee
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Patent number: 8906866Abstract: Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.Type: GrantFiled: March 15, 2013Date of Patent: December 9, 2014Assignees: BioSource Pharm, Inc., Cubist Pharmaceuticals, Inc.Inventors: William V. Curran, Christopher M. Liu, Amy C. D. Bombardier, Richard A. Leese, You Seok Hwang, Blaise S. Lippa, Yanzhi Zhang
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Patent number: 8901070Abstract: The present disclosure includes methods and compositions for treating any condition involving prostatitis and similar diseases and/or conditions. These methods and compositions involve the use of targeted modified pore-forming proteins, including variant proaerolysin proteins.Type: GrantFiled: September 10, 2012Date of Patent: December 2, 2014Assignee: Sophiris Bio, Corp.Inventor: J. Curtis Nickel
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Patent number: 8889826Abstract: Disclosed herein are novel peptides and protected peptides. These compounds can be derived from naturally occurring peptides, such as those selected from colistin, circulin A, polymyxin A, polymyxin B, polymyxin D, octapeptin B, octapeptin C, and [Ile7]polymyxin B1. Also disclosed are pharmaceutical compositions containing the new peptides, as well as methods for preparing the novel peptides and protected peptides.Type: GrantFiled: July 1, 2005Date of Patent: November 18, 2014Assignee: BioSource Pharm, Inc.Inventors: Richard A. Leese, Noreen Francis, William V. Curran, Donald B. Borders, Howard Jarolmen
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Patent number: 8785374Abstract: The present invention provides novel peptides that inhibit and/or reduce the opening of mammalian tight junctions, i.e. peptide tight junction antagonists. The present invention also provides methods for the treatment of excessive or undesirable permeability of a tissue by administering to a subject suffering from such a condition a composition comprising a peptide tight junction antagonist of the invention.Type: GrantFiled: October 20, 2008Date of Patent: July 22, 2014Assignee: Alba Therapeutics CorporationInventor: Amir Tamiz
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Publication number: 20140142024Abstract: Described herein is a method of mitigating, in a subject (individual), tissue injury resulting from exposure to radiation (accidental/unintentional or intentional, such as therapeutic), chemoradiotherapy, disease, toxin, or drug or biologic mediated therapy.Type: ApplicationFiled: April 5, 2012Publication date: May 22, 2014Applicants: Children's Medical Center Corporation, Dana-Farber Cancer Institute, Inc.Inventors: Eva Guinan, Ofer Levy
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Patent number: 8669226Abstract: The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.Type: GrantFiled: October 7, 2011Date of Patent: March 11, 2014Assignee: Morehouse School of MedicineInventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Martin Neville Shelton
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Patent number: 8637040Abstract: Peptides generated from a random library that are bound by a monoclonal antibody to Chlamydial glycolipid exoantigen (GLXA) and thus mimic this antigen are disclosed. Peptides that correspond to antigen-binding regions of an anti-idiotypic antibody (mAb2) specific for anti-GLXA antibody (Ab1) which act as molecular mimics of GLXA are also disclosed used as immunogens to induce broadly reactive genus-specific anti-chlamydial antibodies. These peptides and immunogenic DNA encoding the mAb2-like peptides, microparticle or nanoparticle formulations and other formulations of these peptides are disclosed as are methods for immunizing subjects to obtain genus-specific anti-chlamydial antibodies and to treat or prevent Chlamydia-associated or induced rheumatoid arthritis.Type: GrantFiled: September 21, 2009Date of Patent: January 28, 2014Assignee: National Institute of Health (NIH), U.S. Dept. of Health and Human Services (DHHS)Inventors: Judith Whittum-Hudson, Alan P. Hudson
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Patent number: 8470769Abstract: The present invention relates to peptides comprising amino acids according to Formula I ((X)l(Y)m)n??(I) wherein l, m and n are integers from 0 to 10; X and Y, which may be the same or different, are an amino acid selected from the group consisting of hydrophobic amino acids and/or cationic amino acids, together with methods for the use of the peptides in the treatment of microbial infections.Type: GrantFiled: November 30, 2011Date of Patent: June 25, 2013Assignee: Novabiotics, Ltd.Inventor: Deborah O'Neil
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Patent number: 8470765Abstract: A novel polypeptide, and an antibacterial agent, antifungal agent and/or antiseptic containing as an effective ingredient the polypeptide are disclosed. The polypeptide of this invention has an amino acid sequence shown in SEQ ID NOs:1 to 12 and 13 to 31. This antibacterial agent, antifungal agent and/or antiseptic is useful for the prevention, amelioration or treatment of diseases such as burn, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliterans, cellulitis, acute lymphangitis, lymphadenitis, erysipelas, skin abscess, necrotizing subcutaneous infection, staphylococcal scalded skin syndrome (SSSS), folliculitis, facial furuncle, suppurative hidradenitis, carbuncle, infectious paronychia, erythrasma and severe infection (sepsis).Type: GrantFiled: March 5, 2010Date of Patent: June 25, 2013Assignee: AnGes MG, Inc.Inventors: Takefumi Gemba, Hideki Tomioka, Nao Tamura, Akiko Tenma
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Patent number: 8415307Abstract: Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.Type: GrantFiled: June 23, 2011Date of Patent: April 9, 2013Assignees: BioSource Pharm, Inc., Cubist Pharmaceuticals, Inc.Inventors: William V. Curran, Christopher M. Liu, Amy C. D. Bombardier, Richard A. Leese, You Seok Hwang, Blaise S. Lippa, Yanzhi Zhang
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Patent number: 8377867Abstract: Treatments of trichomonas, propionibacterium, or yeast infection using an epinecidin-1 peptide or an anti-lipopolysaccharide factor peptide.Type: GrantFiled: January 11, 2010Date of Patent: February 19, 2013Assignee: Academia SinicaInventors: Jyh-Yih Chen, Chia-Yu Pan
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Patent number: 8329644Abstract: The present invention provides actagardine, actagradine B and deoxy actagardine B derivatives of formula (I), wherein: X1 denotes that the residue is Leu; Val; or Ile; X2 denotes that the residue is Leu; Val; or Ile; R1 represents an alkyl or heteroalkyl group, substituted by at least one hydroxyl substituent, and R2 represents hydrogen, or an alkyl or heteroalkyl group, optionally substituted by at least one hydroxyl substituent, or R1 and R2 taken together with the nitrogen atom represent a heterocyclic group having at least one hydroxyl substituent, wherein the heterocyclic group optionally further contains one or more heteroatoms; Z is an amino acid residue, —NR3R4, —NR5COR6, —NR5C(O)OR6; —NR5SOR6, NR5SO2R6; —NR5C(S)NR6R7, —NR5C(NR8)NR6R7, or —N?R9, where R3, R4, R5, R6, R7, R8 and R9 are independently hydrogen, or a group, optionally substituted, selected from alkyl, heteroalkyl, aryl, heteroaryl, aralkyl and heteroaralkyl, with the proviso that R9 is not hydrogen; and Y is —S— or —S(O)—.Type: GrantFiled: July 18, 2008Date of Patent: December 11, 2012Assignee: Novacta Biosystems LimitedInventor: Sjoerd Nicolaas Wadman
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Patent number: 8324153Abstract: Disclosed herein are cell penetrating peptides useful as treatment for Human Immunodeficiency Virus.Type: GrantFiled: May 5, 2009Date of Patent: December 4, 2012Assignee: New York Blood Center, Inc.Inventors: Asim Kumar Debnath, Hongtao Zhang, Francesca Curreli
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Patent number: 8198067Abstract: A microbial biomass, made from algae, bacteria, fungi, yeast, or combinations thereof, provides a feed for animals raised either in agriculture or aquaculture. A feed additive, and a therapeutic composition can also be made from a microbial biomass of algae, bacteria, fungi, yeast, or combinations thereof. The feed, feed additive, and therapeutic composition can comprise one or more proteins, peptides, antibodies, antibody fragments, or a combination thereof, wherein said proteins, peptides, antibodies, antibody fragments, or a combination thereof are non-native to the microbes of the biomass. The biomass can have therapeutic, bioactive, nutritional, and/or immunogenic properties.Type: GrantFiled: June 9, 2006Date of Patent: June 12, 2012Assignee: Advanced Bionutrtion CorporationInventor: David J. Kyle
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Patent number: 8173768Abstract: A method for preventing a break out of a neurodegenerative disease in an individual and for treating an individual suffering from a neurodegenerative disease comprising the administration of an effective amount of an antimicrobial and neurotrophic peptide.Type: GrantFiled: July 13, 2009Date of Patent: May 8, 2012Assignees: Centre National de la Recherche Scientifique, Universite des Sciences et Technologies de LilleInventors: Aurélie Tasiemski, Michel Salzet
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Patent number: 8026219Abstract: The present invention relates to novel linear peptides with antimicrobial activity. Said peptides are made up of 11 amino acids, and they have the amino group of the amino acid constituting the N-terminal end in a non-derived form or functionalized with an acetyl group, p-toluene sulphonyl, benzyl or benzoyl. The amino acid constituting the C-terminal end of said peptides is in carboxamide form. The invention describes the synthesis and use of said peptides as antimicrobial agents to combat pathogenic bacteria for plants. The invention also relates to compositions containing said peptides and an auxiliary agent, and to a method for preventing and treating infections and diseases of plants caused by pathogenic bacteria.Type: GrantFiled: April 24, 2007Date of Patent: September 27, 2011Assignee: Universitat de GironaInventors: Eduard Bardaji Rodriguez, Emili Montesinos Segui, Esther Badosa Romacho, Lidia Feliu Soley, Marta Planas Grabuleda, Rafael Ferre Malagón
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Publication number: 20110230393Abstract: The present invention is directed to isolated and chimeric polypeptides of bacteriophage origin having antibiotic activity and use thereof in the treatment and control of bacterial infections. Specifically, the present invention is directed to the use of a novel antibacterial polypeptide derived from bacteriophage F87s/06 and chimeric constructs thereof, and their use for the treatment and control of infections caused by gram-positive bacteria, including Staphylococcus aureus.Type: ApplicationFiled: October 9, 2009Publication date: September 22, 2011Inventors: Miguel Angelo Da Costa Garcia, Madalena Maria Vilela Pimentel, Carlos Jorge Sousa de São José
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Patent number: 7994295Abstract: Recombinant viruses, isolated nucleic acids and methods of generating same encoding for a Rhabdoviral G stem polypeptide are disclosed. Methods, compounds and compositions for target cell fusion potentiation mediated by Rhabdoviral G stem polypeptides, and applications of same are provided.Type: GrantFiled: December 23, 2002Date of Patent: August 9, 2011Assignee: The University of Tennessee Research CorporationInventors: Michael A. Whitt, Clinton S. Robison
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Patent number: 7985832Abstract: The invention relates to antimicrobial cathelicidin polypeptides related to a 38 amino acid peptide having SEQ ID NO:4. The invention provides for polypeptides having broad spectrum antimicrobial activity, nucleic acids and expression vectors encoding such polypeptides, as well as host cells and methods of reducing survival of a microbe. In addition, the invention also provides compositions, as well as articles of manufacture, that comprise a broad spectrum antimicrobial polypeptide.Type: GrantFiled: December 29, 2006Date of Patent: July 26, 2011Assignee: Kansas State University Research FoundationInventors: Tonatiuh Melgarejo, Frank Blecha, Yongming Sang, Maria Teresa Ortega
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Patent number: 7977308Abstract: Dipeptides and derivatives and analogs, such as Pal-KT have been developed. These dipeptides, derivatives and analogs may be used alone or in an additive, to produce cosmetics, topical pharmaceuticals and personal care products, particularly for skin care. Methods of making the dipeptides, derivatives, analogs and additives containing same are also described.Type: GrantFiled: April 27, 2005Date of Patent: July 12, 2011Assignee: SedermaInventor: Karl Lintner
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Patent number: 7939492Abstract: Recombinant fragments of Factor C are disclosed. These proteins and peptides show great potency in recognizing, binding to, neutralizing and removing endotoxin. These molecules can thus be used for anti-microbial, anti-endotoxin, and anti-sepsis therapy. SSCrFCES is a 38 kDa protein representing the LPS-binding domain of Factor C. The ability of SSCrFCES to bind lipid A was analyzed using an ELISA-based assay as well as surface plasmon resonance. Surface plasmon resonance similarly carried out for SSCrFC-sushi-1,2,3-GFP, SSCrFC-sushi-1GFP, and SSCrFC-sushi-3GFP confirmed their superior affinity for endotoxin. The 50% endotoxin-neutralizing concentration of SSCrFCES against 200 EU of endotoxin is 0.069 ?M, suggesting that SSCrFCES is an effective inhibitor of LAL coagulation cascade. Although partially attenuated by human serum, as low as 1 ?M of SSCrFCES inhibits the LPS-induced secretion of hTNF-? and hIL-8 by THP-1 and human pheripheral blood mononuclear cells with a potency more superior than polymyxin B.Type: GrantFiled: October 12, 2007Date of Patent: May 10, 2011Assignee: National University of SingaporeInventors: Jeak L. Ding, BoW Ho, Nguan S. Tan
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Publication number: 20100279861Abstract: Novel isoxazolidinone compounds useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops are described. Two novel strains of fungi, ATCC No. PAT-7894 and ATCC No. PAT-7895, are disclosed for the preparation of the described isoxazolidinone compounds.Type: ApplicationFiled: August 12, 2008Publication date: November 4, 2010Inventors: Gerald F Bills, Javier Collado, Craig A. Parish, Fernando Pelaez, Gonzalo Platas, Terry Roemer
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Publication number: 20100240577Abstract: Novel bacteriocins produced by novel bacterial strains are used for at least reducing the levels of colonization by at least one target bacteria in animals, especially poultry.Type: ApplicationFiled: March 19, 2010Publication date: September 23, 2010Inventors: Norman J. Stern, Edward A. Svetoch, Nikolay N. Urakov, Boris V. Eruslanov, Larisa I Volodina, Yuri N. Kovalev, Tamara Y. Kudryavtseva, Vladimir V. Perelygin, Victor D. Pokhilenko, Vladimir P. Levchuk, Valery N. Borzenkov, Olga E. Svetoch, Eugeni V. Mitsevich, Irina P. Mitsevich