Lignin Or Derivative Doai Patents (Class 514/22)
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Patent number: 6936285Abstract: The invention relates to the use of Ginkgo biloba extracts for preparing a medicament intended to ease the withdrawal of individuals dependent on the consumption of a substance engendering dependency and/or addiction, such as in particular alcohol, amphetamines, tobacco, drugs inducing toxicomania.Type: GrantFiled: December 1, 1998Date of Patent: August 30, 2005Assignee: Societe de Conseils de Recherches d'Application Scientifiques (S.C.R.A.S.Inventor: Katy Drieu
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Patent number: 6835715Abstract: A novel mammalian dihydroouabain-like factor is disclosed which substantially fails to cross-react with mammalian ouabain-like factor (OLF) for binding to anti-OLF antibody, but cross-reacts with plant-related dihydroouabain (dho) for binding to anti-dho antibody, has maximal u.v. absorbance at 196 nm, has a non-peptidic, non-lipidic chemical structure and a fully hydrogenated lactone ring, has a concentration-dependent Na+,K+-ATPase (sodium pump) catalytic inhibitory activity which is 10-fold lower than OLF and 3-fold higher than plant-related dihydroouabain, and a high pressure liquid chromatography elution time about the same as dho. This factor is useful for therapy for congestive heart failure. An antibody and antibody fragments having affinity for mammalian Dh-OLF but not for OLF, and diagnostic and therapeutic methods comprise the antibody and means for quantifying the antibody and are useful for treating a condition caused by high level of OLF or Dh-OLF.Type: GrantFiled: February 11, 2000Date of Patent: December 28, 2004Assignee: University of Louisville Research Foundation, Inc.Inventors: Roland Valdes, Jr., Hassan M. A. M. Qazzaz
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Patent number: 6833359Abstract: A method for reducing bacterial and fungal soil pathogens which comprises applying to a soil a chemically effective amount of a lignosulfonate, the amount preferably being between 0.05% and about 5% on a volume/weight basis. The method is effective in controlling a number of soil pathogens and can be used to treat the soil for diseases such as potato scab disease.Type: GrantFiled: May 11, 2001Date of Patent: December 21, 2004Assignee: Earth Alive Resources Inc.Inventor: George Lazarovits
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Publication number: 20040224902Abstract: Process for obtaining lignan from plant material by extraction with an extraction solvent and separation of the liquid fraction from the plant material. The separated liquid fraction containing the lignan product is subjected to further processing to remove cyanogenic sugars and other impurities. The resulting lignan containing product may be formulated for the treatment of various conditions, such as cancer, diabetes, hypertension, lupus, and atherosclerosis.Type: ApplicationFiled: June 4, 2004Publication date: November 11, 2004Inventors: Rishi Shukla, Ahmad K. Hilaly, Kevin M. Moore
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Publication number: 20040208939Abstract: The invention relates to the use of combinations of fatty acids and specific inhibitors of delta-5 desaturase activity in a nutritional supplement to modulate the inflammatory state of a mammal. The nutritional supplement is composed of various oils selected in combination to enhance the production of anti-inflammatory eicosanoids derived from omega 6 fatty acids while simultaneously decreasing the production of pro-inflammatory eicosanoids derived from omega 6 fatty acids. In one embodiment, the invention features a combination of a fish oil, an oil containing gamma linolenic acid (GLA), and a sesame oil extract rich in one or more lignans (such as sesamol and sesamin) that are specific inhibitors of delta-5 desaturase activity.Type: ApplicationFiled: April 18, 2003Publication date: October 21, 2004Inventors: Barry Sears, Stacey Bell
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Publication number: 20040048804Abstract: This invention relates to methods for prevention of cancers, certain non-cancer, hormone dependent diseases and/or cardiovascular diseases in a person, based on administering of hydroxymatairesinol to said person. The invention also concerns a method for increasing the level of enterolactone or another metabolite of hydroxymatairesinol in a person's serum thereby causing prevention of a cancer or a certain non-cancer, hormone dependent disease in a person, based on administering of hydroxymatairesinol to said person. Furthermore, this invention relates to pharmaceutical preparations, food additives and food products comprising hydroxymatairesinol.Type: ApplicationFiled: August 13, 2003Publication date: March 11, 2004Inventors: Markku Ahotupa, Christer Eckerman, Lauri Kangas, Sari Makela, Niina Saarinen, Risto Santti, Anni Warri
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Publication number: 20030216326Abstract: Lignins have a number of bioactivities such as the inhibition of cellular proliferation and inhibition of thrombus formation which are applicable for their use in coating for medical devices and pharmaceuticals. As such, a composition comprising lignins and methods for making and using the same are provided herein.Type: ApplicationFiled: March 20, 2003Publication date: November 20, 2003Inventor: Hojabr Alimi
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Publication number: 20030215529Abstract: In accordance with the present invention, novel compositions useful for the treatment of the cytopathogenic effects of an enveloped virus in mammals have been discovered by extraction and purification from the spikes of Prunella vulgaris. In particular, invention compositions comprise a lignin-carbohydrate complex as an active ingredient for inhibition of viral infection in a mammal. In accordance with an embodiment of the present invention, it has been discovered that invention compositions are effective agents for the prophylaxis and therapy in mammals of diseases caused by enveloped viruses, e.g., herpes simplex virus. Methods for producing invention compositions and uses therefor are also provided.Type: ApplicationFiled: October 4, 2002Publication date: November 20, 2003Applicants: Dalhousie University, The Chinese University of Hong KongInventors: Song F. Lee, Paul P.H. But, Spencer H.S. Lee, Vincent E.C. Ooi, Hong-Xi Xu, Yongwen Zhang, Wai-Chong Foong, Jonathan Blay
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Patent number: 6613332Abstract: An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process.Type: GrantFiled: March 29, 2000Date of Patent: September 2, 2003Assignee: The University of CincinnatiInventors: Jacob Gabriel Michael, Allen Litwin
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Publication number: 20030144216Abstract: Methods for prevention of cancers, precancers, certain non-cancer, hormone dependent diseases and/or cardiovascular diseases in a person suffering from coeliac disease, based on administering of a lignan to the person. A method for increasing the level of enterolactone or another metabolite of a lignan in a person's serum is also disclosed, where the person suffers from coeliac disease, thereby causing prevention of a cancer or a certain non-cancer, hormone dependent disease in the person, based on administering of a lignan to the person.Type: ApplicationFiled: January 25, 2002Publication date: July 31, 2003Inventor: Mikko Unkila
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Publication number: 20030134803Abstract: This invention provides methods, compositions and contraceptive devices that use sulfonated compounds that interact with sperm to inhibit fertilization. Natural contraceptive methods, compositions and contraceptive devices are also included. These natural contraceptives use sulfonated compounds isolated from natural sources. Methods, compositions and contraceptive devices are also provided that use a lignin and/or a derivative thereof.Type: ApplicationFiled: February 13, 2002Publication date: July 17, 2003Applicant: The Regents of the University of CaliforniaInventors: Gary N. Cherr, Edward R. Salinas
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Publication number: 20030100514Abstract: This invention relates to a method of inhibiting the overactivity of phagocytes or lymphocytes in an individual by administering to said individual an effective amount of a lignan, whereinType: ApplicationFiled: November 26, 2001Publication date: May 29, 2003Inventors: Markku Ahotupa, John Eriksson, Lauri Kangas, Mikko Unkila, Janne Komi, Merja Perala, Helena Korte
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Publication number: 20030078212Abstract: The present invention relates to pharmaceutical compositions containing poly(ADP-ribose) glucohydrolase inhibitors, also known as PARG inhibitors, and methods of using the same for inhibiting or decreasing free radical induced cellular energy depletion, cell damage, or cell death. More particularly, the present invention relates to pharmaceutical compositions containing poly (ADP-ribose) glucohydrolase inhibitors such as glucose derivatives; lignin glycosides; hydrolysable tannins including gallotannins and ellagitannins; adenoside derivatives; acridine derivatives including 6,9-diamino-2-ethoxyacridine lactate monohydrate; tilorone analogs including tilorone R10.556, daunomycin or daunorubicin hydrochloride; ellipticine; proflavine; and other PARG inhibitors; and their method of use in treating or preventing diseases or conditions due to free radical induced cellular energy depletion and/or tissue damage resulting from cell damage or death due to necrosis, apoptosis, or combinations thereof.Type: ApplicationFiled: October 30, 1998Publication date: April 24, 2003Inventors: JIA-HE LI, JIE ZHANG
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Publication number: 20030064938Abstract: A composition is prepared by extracting phytochemicals from plant matter. This composition is enriched preferably in isoflavones, lignans, saponins, catechins and phenolic acids. Soy is the preferred source of these chemicals: however, other plants may also be used, such as red clover, kudzu, flax, and cocoa. The composition is a dietary supplement for treatment of various cancers, pre- and post-menstrual syndromes, and various other disorders.Type: ApplicationFiled: May 1, 2002Publication date: April 3, 2003Inventors: Mark Empie, Eric Gugger
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Publication number: 20030060420Abstract: The phytoestrogen secoisolariciresinol diglucoside (SDG) and other beneficial compounds are extracted from oil-free flaxseed meal or flaxseed hulls. The phytoestrogens are extracted by aqueous ethanol solvent, which is then filtered and removed by evaporation to isolate the complexed phytoestrogens. The complexed phytoestrogens are then hydrolyzed with a base to provide uncomplexed phytoestrogens. The uncomplexed phytoestrogens are subsequently freeze dried and stabilized with a vegetable oil. The stabilized phytoestrogens can be formulated into products for consumption.Type: ApplicationFiled: January 8, 2002Publication date: March 27, 2003Inventors: Rick Heintzman, Michael L. Bennett
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Publication number: 20030055007Abstract: PurposesType: ApplicationFiled: August 2, 2001Publication date: March 20, 2003Inventor: Kazuo Sakuma
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Patent number: 6518247Abstract: In order to lower the painfulness of injection of the remedy containing the products of lignin basic hydrolysis and oxidation, pyrophosphate, NaCl and water the value of pH of the remedy is adjusted to a neutral one by the addition of HCl.Type: GrantFiled: May 15, 2001Date of Patent: February 11, 2003Assignee: Obschestvo s Ogranichennoi Otvetstvennostiju “Ligpharm”Inventors: Dmitriy Victorovich Petukhov, Valeriy Aphanasievich Trophimov, Vladimir Alexandrovich Philov, Valentina Vasilievna Reztsova, Boris Timopheievich Pinchuk
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Publication number: 20030003168Abstract: A composition is prepared by extracting phytochemicals from plant matter. This composition is enriched preferably in isoflavones, lignans, saponins, catechins and phenolic acids. Soy is the preferred source of these chemicals: however, other plants may also be used, such as red clover, kudzu, flax, and cocoa. The composition is a dietary supplement for treatment of various cancers, pre- and post-menstrual syndromes, and various other disorders.Type: ApplicationFiled: May 1, 2002Publication date: January 2, 2003Inventors: Mark Empie, Eric Gugger
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Patent number: 6495170Abstract: A method for increasing the presence of glutathione in cells including treating or preventing impaired liver function by administering a composition which includes a precursor of gluthathione, and enhancer of glutathione biosynthesis, and a third component which is a lignan or the third component is a combination of an enhancer of gluthathione regeneration and an enhancer of glutathione-mediated conjugation. The precursor of gluthathione is cysteine or is a functional equivalent of cysteine which yields cysteine when administered to a mammal undergoing treatment.Type: GrantFiled: August 16, 2000Date of Patent: December 17, 2002Assignee: N. V. NutriciaInventors: Hobbe Friso Smit, Klaske van Norren, Robert Johan Joseph Hageman
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Publication number: 20020187211Abstract: A composition is prepared by extracting phytochemicals from plant matter. This composition is enriched preferably in isoflavones, lignans. saponins. catechins and phenolic acids. Soy is the preferred source of these chemicals: however other plants may also be used, such as red clover, kudzu, flax, and cocoa. The composition is a dietary supplement for treatment of various cancers, pre- and post-menstrual syndromes, and various other disorders.Type: ApplicationFiled: May 1, 2002Publication date: December 12, 2002Inventors: Mark Empie, Eric Gugger
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Patent number: 6486215Abstract: Contact lens care compositions for the treatment of hard contact lenses are disclosed. The compositions are useful for rinsing, cleaning, disinfecting and storing of hard contact lenses. The compositions contain an unique gelling system involving galactomannan polysaccharides and borates to allow for the conditioning of the lens when it is reinserted in the eye of the user. Methods of using these compositions are also disclosed.Type: GrantFiled: June 18, 2001Date of Patent: November 26, 2002Assignee: Alcon Manufacturing, Ltd.Inventor: Bahram Asgharian
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Patent number: 6482447Abstract: Compositions comprising lycopene, Serenoa repens, Pygeum africanum, and Urtica dioica are provided. The compositions are preferably formulated with an alcohol extract of the dried, cut plant parts. Methods of using such compositions for treating various conditions and diseases, including benign prostatic hypertrophy and prostate cancer are also provided.Type: GrantFiled: June 18, 2001Date of Patent: November 19, 2002Inventor: Chase Revel
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Patent number: 6428807Abstract: An immunostimulating complex matrix comprising a saponin preparation, a sterol and a phospholipid, the matrix further comprising a metal-chelating moiety capable of binding a protein or polypeptide having at least one chelating amino acid sequence in the presence of metal ions. An immunogenic immunostimulating complex which comprises this matrix and an immunogenic protein or polypeptide having at least one chelating amino acid sequence, the protein or polypeptide being bound to the matrix in the presence of metal ions.Type: GrantFiled: August 11, 1999Date of Patent: August 6, 2002Assignee: CSL LimitedInventors: Roderick Ian MacFarlan, Jim Malliaros
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Publication number: 20020091110Abstract: Dietary compositions and methods employ a mammal food base and a component comprising estrogen, androgen or a mixture thereof in an amount sufficient to reduce weight gain normally incurred in the mammal type subsequent to neutering, castration, spaying, ovariectomy or ovariohysterectomy, or post menopause. Preferably, the component comprises phytoestrogen, phytoandrogen or a mixture thereof. The compositions are adapted for administration to the mammal on a regular, preferably daily, basis.Type: ApplicationFiled: January 9, 2002Publication date: July 11, 2002Inventors: Geza Bruckner, Joseph Szabo
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Patent number: 6399115Abstract: Compositions comprising lycopene, Serenoa repens, Pygeum africanum, and Urtica dioica are provided. The compositions are preferably formulated with an alcohol extract of the dried, cut plant parts. Methods of using such compositions for treating various conditions and diseases, including benign prostatic hypertrophy and prostate cancer are also provided.Type: GrantFiled: June 18, 2001Date of Patent: June 4, 2002Inventor: Chase Revel
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Publication number: 20020061854Abstract: This invention relates to methods for prevention of cancers, certain non-cancer, hormone dependent diseases and/or cardiovascular diseases in a person, based on administering of hydroxymatairesinol to said person. The invention also concerns a method for increasing the level of enterolactone or another metabolite of hydroxymatairesinol in a person's serum thereby causing prevention of a cancer or a certain non-cancer, hormone dependent disease in a person, based on administering of hydroxymatairesinol to said person. Furthermore, this invention relates to pharmaceutical preparations, food additives and food products comprising hydroxymatairesinol.Type: ApplicationFiled: October 10, 2001Publication date: May 23, 2002Inventors: Markku Ahotupa, Christer Eckerman, Lauri Kangas, Sari Makela, Niina Saarinen, Risto Santti, Anni Warri
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Patent number: 6300327Abstract: Compositions and methods for use in modulating neurotrophin activity, wherein the active agent is at least one compound which potentiates neurotrophin activity. A preferred class of active agents is K-252 compounds, including both microbial metabolites and derivatives thereof. Neurotropin activity is modulated by administration of an effective amount of at least one compound which potentiates neurotrophin activity. Potentiation of NT-3 by K-252b, K-252a, KT5720, and KT5823 provides a model for therapeutic intervention in a variety of neuropathological conditions.Type: GrantFiled: February 6, 1997Date of Patent: October 9, 2001Assignee: The University of Southern CaliforniaInventors: Beat J. Knusel, Franz F. Hefti
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Patent number: 6235707Abstract: The invention relates to new peptidyl-arginine aldehyde compounds of formula (I) Q-D-Xaa-Pro-Arg-H (I) wherein Q represents an acyl group of formula Q′—OCO, wherein Q′ represents an alkyl-group with 1-3 carbon atoms, D-Xaa represents a 3-cyclobutyl-D-alanyl- or 3-cyclopentyl-D-alanyl group, Pro represents an L-prolyl group, and Arg represents an L-arginyl group, and acid-addition salts thereof, and pharmaceutical compositions comprising them, which are suitable for the prevention and cure of thrombosis and accelerated blood clotting.Type: GrantFiled: November 23, 1998Date of Patent: May 22, 2001Assignee: Gyogyszerkutato Intezet Kft.Inventors: Sándor Bajusz, Attila Juhász, Éva Barabás, András Fehér, Gabriella Szabó, Erzsébet Széll née Hasenöhrl, Irén Véghelyi née Fauszt, Emilia Lavich née Oszko, Éva Kaszás, József Langó, Imre Moravcsik, Ágnes Szeker née Peszeky, Zsuzsanna Taschler née Pásztor, Gábor Tóth, Zsuzsanna Mohai née Nagy, Anna Mária Szalkay née Hollósi, Klára Makk née Ocskay
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Patent number: 6174529Abstract: An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process. In addition to being immunogenic, when administered orally, encapsulated allergen has a therapeutic effect in the treatment of human allergies.Type: GrantFiled: October 11, 1997Date of Patent: January 16, 2001Assignee: University of CincinnatiInventors: J. Gabriel Michael, Allen Litwin
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Patent number: 6123957Abstract: The invention relates to a method of treating periodontal disease and related disorders to regenerate lost tissues, which includes the steps of: combining at least one tissue regenerative agent with at least one cellular recognition agent to form a therapeutic treatment composition and applying the therapeutic treatment composition to a periodontal treatment site. The cellular recognition agent increases the periodontal tissue regeneration at the periodontal treatment site relative to the therapeutic treatment composition lacking the cellular recognition agent. The invention also includes the therapeutic composition.Type: GrantFiled: July 16, 1997Date of Patent: September 26, 2000Inventor: Gary R. Jernberg
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Patent number: 5932207Abstract: An active ingredient complex to promote the growth of cells, tissue and/or organs is disclosed. The complex comprises the following form ingredients: a structural component, a recruiting component, an adhesion component and an adherence component.Type: GrantFiled: December 7, 1994Date of Patent: August 3, 1999Inventor: Karlheinz Schmidt
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Patent number: 5856313Abstract: A natural carob fiber includes 50-65% lignin, 15-25% cellulose, 15-25% hemicellulose, 0.5-2 % pectin, 3-7% tannins and 4-8% moisture. A method of using the natural carob fiber includes the step of ingesting the natural carob fiber.Type: GrantFiled: February 21, 1996Date of Patent: January 5, 1999Assignee: Compania General del Algarrobo de Espana, S.A.Inventors: Ana Maria Requejo Marco, Baltasar Ruiz-Rosa Calvo de Mora, Carlos Sanjuan Diaz
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Patent number: 5834423Abstract: The present invention is a pharmaceutical composition used as an antiviral agent, a diarrheal remedy, an antiulcer agent, an anti-inflammatory agent, an anti-allergic agent and an agent for promoting the proliferation of Bifidobacteria, characterized by containing a sialic acid derivative as an active ingredient. The method for producing a sialic acid derivative of the present invention is characterized in that an almond or apricot seed is added to an avian egg yolk, by which the desired product can easily be obtained in a high yield.Type: GrantFiled: March 15, 1996Date of Patent: November 10, 1998Assignee: Taiyo Kagaku Co., Ltd.Inventors: Mamoru Koketsu, Masakazu Nishizono, Teruhiko Nitoda, Yuko Enoki, Hiroshi Kawanami, Lekh Raj Juneja
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Patent number: 5792754Abstract: A nutritional composition, suitable for enteral administration, is described which contains 5-120 g of composite dietary fibre per daily dosage of the composition or per 2000 kcal, which fibre consists of 15-50 wt. % of soluble non-starch polysaccharides, such as gum arabic or pectin, 15-45 wt. % of insoluble non-starch polysaccharides, such as cellulose and hemicellulose, and 8-70 wt. % of oligosaccharides and/or resistant starch and/or lignin. The oligosaccharides such as inulin or hydrolyzed inulin can be present at a level of 8-40 wt. %. The resistant starch may be present at a level of 5-30 wt. %. The composition may further contain carbohydrates and/or fats and/or proteinaceous material and may be dry or liquid. It may be used as a complete food or a food supplement, e.g. for clinical patients or infants.Type: GrantFiled: August 5, 1996Date of Patent: August 11, 1998Assignee: N.V. NutriciaInventors: Ceirwen Jane Green, Roelof Andre Bork, Robert Johan Joseph Hageman, Jan Albertus Boerma, Klaske Anne Van Hoey-De Boer
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Patent number: 5739114Abstract: Immunosuppressive cyclolignan derivatives are provided of formula (I) or (II): ##STR1## in which R.sup.1 is hydrogen, hydroxy, alkoxy; R.sup.2 and R.sup.3 are hydrogen, alkyl, acyl, or together R.sup.2 and R.sup.3 form a group --CHR.sup.4 --; R.sup.4 is hydrogen, alkyl, alkenyl, hydroxyalkyl, (poly)haloalkyl, aryl, acyloxyalkyl, alkoxy, carboxyalkyl, alkoxycarbonyl, carbamoyl; R.sup.5 when present is hydrogen, alkyl, alkenyl, aryl, (poly)haloalkyl, acyl, carbamoyl, or thiocarbamoyl; R.sup.6 is alkyl, hydroxyalkyl, haloalkyl, acyl, acyloxyalkyl, carboxy or alkoxycarbonyl; Ar is 3,4,5-trialkoxyphenyl or 4-hydroxy-3,5-dialkoxyphenyl; and X is nitrogen or oxygen.Type: GrantFiled: November 13, 1995Date of Patent: April 14, 1998Assignee: Universidad de SalamancaInventors: Marina Gordaliza, Maria Angeles Castro, Arturo San Feliciano, Jose Maria Miguel del Corral, Maria Luisa Lopez, Glynn T. Faircloth
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Patent number: 5721222Abstract: The present invention relates to certain novel heterocyclic ketones which are 1-pyridylacetamide ketones of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic ketones, processes for preparing the heterocyclic ketones, pharmaceutical compositions containing such heterocyclic ketones and methods for their use.Type: GrantFiled: August 25, 1995Date of Patent: February 24, 1998Assignee: ZENECA LimitedInventors: Peter Robert Bernstein, Andrew Shaw, Royston Martin Thomas, Chris Allan Veale, Peter Warner, Donald John Wolanin
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Patent number: 5714473Abstract: The present invention is concerned with the use of flavolignans as adjuvants in the case of chemotherapeutic tumour treatment and for the protection of cells in the urogenital region.Type: GrantFiled: January 24, 1995Date of Patent: February 3, 1998Assignee: Madaus AGInventors: Hans Lentzen, Ulrich Mengs, Karl-Peter Odenthal, Hilmar Stolte
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Patent number: 5698524Abstract: A method of treating a patient suffering with a viral infection (such as HIV) by administering to the patient an effective anti-viral amount of a composite molecular active substance group, which is produced by the process comprising: (a) preparing lignin units by carrying out an extraction in an aqueous media under weakly acidic or alkaline conditions of wood or wood-like materials and/or plant-cell cultures and separating-off the resultant insoluble solids; (b) preparing lignoid units by carrying out an aqueous alkaline extraction at a pH of 7 to 14 of starting materials selected from the group consisting of wood-incarbonization products and bioconverted wood-like materials and separating-off the resultant alkali-insoluble solids; and (c) preparing a water-soluble mixed polymer by reacting the lignin units from step (a) with the lignoid units from step (b), under aqueous alkaline isolating by ultrafiltration a low molecular weight fraction having a molecular weight of no more than 3000 daltons of the mixedType: GrantFiled: June 5, 1995Date of Patent: December 16, 1997Inventors: Walter Mach, deceased, by Chantal Mach, legal representative
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Patent number: 5696094Abstract: A method of controlling soil borne pests and pathogens, e.g., nematodes in which a predisposition material is incorporated in the soil which predisposes the pests or pathogens by weakening their resistance to attack by soil microbes. The predisposing material may be a lignosulfonate or other organic material which penetrates the cuticle of the pests or pathogens and renders them more amenable to attack by soil microbes. Preferably the predisposition material is accompanied by nutrient material such as a sugar, which may be a natural accompaniment of the predisposition material as in the case with lignosulfonates and/or which may be added. Preferably also the predisposition material is accompanied by macronutrients such as nitrogen and phosphorus macronutrients, also micronutrients and vitamin/co-factor.Type: GrantFiled: May 31, 1996Date of Patent: December 9, 1997Inventor: Thomas T. Yamashita
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Patent number: 5668183Abstract: Novel, stable, cold water-dispersible preparations of fat-soluble substances contain a water-soluble or water-dispersible lignin derivative as the matrix component. These preparations are manufactured by preparing an aqueous emulsion of the fat-soluble substance(s) and the water-soluble or water-dispersible lignin derivative and, if desired, converting this emulsion into a dry powder. The preparations in accordance with the invention can be used not only for animal nutrition but also for human nutrition.Type: GrantFiled: August 8, 1996Date of Patent: September 16, 1997Assignee: Roche Vitamins Inc.Inventor: Bruno Leuenberger
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Patent number: 5614501Abstract: Compositions containing hemicelluloses in combination with polyphenols, methods of preparing the compositions, and methods of treating humans or animals with the composition are provided. Also provided is a method for increasing growth rate, improving feed efficiency and decreasing scour after weaning in an animal by administering an effective amount of the composition to the animal. The hemicelluloses preferably are not consumed by human alimentary enzymes or harmful bacteria, such as putrefactive or pathogenic bacteria, in the gastrointestinal tract, and are consumed by beneficial bacteria, such as bifidobacteria, in the gastrointestinal tract. The polyphenols preferably decrease the amount of harmful bacteria in the gastrointestinal tract. The compositions can optionally contain a carrier or be used as a feed addition and are administered to humans or other animals in an amount sufficient to treat the gastrointestinal disorder.Type: GrantFiled: May 4, 1995Date of Patent: March 25, 1997Assignee: The University of MontanaInventor: Geoffrey N. Richards
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Patent number: 5571687Abstract: The present invention relates, in general, to multidrug resistance and, in particular, to compounds that modulate multidrug resistance transporters. The invention also relates to methods of selecting or designing compounds for the ability to modulate multidrug resistance transporters, and to methods of modulating multidrug resistance.Type: GrantFiled: June 7, 1994Date of Patent: November 5, 1996Assignee: Duke UniversityInventors: Patrick J. Casey, Lili Zhang
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Patent number: 5554596Abstract: A composite molecular active substance group for use in restitutive chemotherapy against viral infections, which is produced by the process comprising: (a) preparing lignin units by carrying out an extraction in an aqueous media under weakly acidic or alkaline conditions of wood or wood-like materials and/or plant-cell cultures and separating-off the resultant insoluble solids; (b) preparing lignoid units by carrying out an aqueous alkaline extraction at a pH of 7 to 14 of starting materials selected from the group consisting of wood-incarbonization products and bioconverted wood-like materials and separating-off the resultant alkali-insoluble solids; and (c) preparing a water-soluble mixed polymer by reacting the lignin units from step (a) with the lignoid units from step (b), under aqueous alkaline isolating by ultrafiltration a low molecular weight fraction having a molecular weight of no more than 3000 daltons of the mixed polymer, taking a cut between 15 to 40 kilodaltons and discarding the resultant resType: GrantFiled: January 27, 1993Date of Patent: September 10, 1996Inventors: Walter Mach, deceased, by Chantal Mach, executor
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Patent number: 5529772Abstract: A method for producing agriculturally active substances such as pesticides to provide improved resistance to environmental degradation, especially heat and ultra-violet light. The method involves the direct reaction of an active protein toxin of a biologically derived pesticide with a UV protectant to form a stable complex having the UV protectant as an integral part of its structure. The method employs lignosulfonates, such as sulfite lignin or sulfonated lignin, or alternately sulfonated lignite, sulfonated tannins, napthalene sulfonates or other related compounds as the UV protectant.Type: GrantFiled: June 9, 1994Date of Patent: June 25, 1996Assignee: LignoTech, USA, Inc.Inventor: Stuart E. Lebo, Jr.
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Patent number: 5484595Abstract: A dibenzocyclooctadiene type lignan can be efficiently prepared by extracting a plant containing a dibenzocyclooctadiene type lignan with a low polar solvent, subjecting the resulting extract to partition extraction with a water-insoluble low polar solvent and a water-soluble high polar solvent, at least one time, and recovering the dibenzocyclooctadiene type lignan from the layer of the water-soluble high polar solvent.Type: GrantFiled: April 6, 1990Date of Patent: January 16, 1996Assignee: Tsumura & Co.Inventors: Yukinobu Ikeya, Hirotoshi Kanatani, Kaoru Nakajima, Hiroshi Mitsuhashi
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Patent number: 5270057Abstract: Disclosed are lyophilized gonadotropin containing preparations containing a dicarboxylic acid salt stabilizer. The particular proteins (e.g. LH, TSH, FSH, or HCG) are in admixture with, and at least partially capable of stabilization by, the particular stabilizer in lyophilized form. The preparations contain a sufficient amount of dicarboxylic acid salt to stabilize the protein in freeze-dried form for a desired time at a desired temperature. Typical dicarboxylic acid salts disclosed are the salts of citric, tartaric, and aspartic acids. The preparations preferably include a non-reducing disaccharide to increase the collapse temperature of the solution to be lyophilized. Methods of making the preparations in lyophilized form and the resulting injectable preparations are also disclosed.Type: GrantFiled: July 13, 1992Date of Patent: December 14, 1993Assignee: Akzo N.V.Inventors: Andreas L. J. de Meere, Marinus A. De Ruiter
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Patent number: 5223258Abstract: An antiviral medicinal composition having spent liquor from kraft pulping and/or processed products thereof (kraft lignin, sulfomethylated and/or sulfopropylated kraft lignin) as major constituents, are effective agents in therapeutic and/or preventive methods against AIDS.Type: GrantFiled: January 11, 1990Date of Patent: June 29, 1993Assignee: Sanyo-Kokusaku Pulp Co., Ltd.Inventors: Makoto Machida, Makoto Yashiro, Kunichika Murakami
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Patent number: 5106753Abstract: The present invention is directed to a simple and inexpensive liquid or dry reagent assay system for detecting nanomolar amounts of manganese in body fluids in microgram per liter concentrations. More specifically, the manganese assay of this invention is directed to the optical detection of a chromogenic reaction, such as the oxidation of a redox indicator, catalyzed by a manganese porphyrin complex.Type: GrantFiled: January 23, 1990Date of Patent: April 21, 1992Assignee: Miles Inc.Inventors: Marvin A. Genshaw, Michael J. Pugia
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Patent number: 4988799Abstract: A lignosulfonate useful pharmacologically as an anti-thrombotic that inhibits deep venous thrombophlebitis without effecting blood coagulation, and which causes no apparent increased bleeding or side effects. The lignosulfonate is isolated from softwood spent sulfite liquor, and is administered in low dosages of from about 0.05 to about 1.0 mg/milliter of blood. A method of making and administering the lignosulfonate is also disclosed.Type: GrantFiled: August 11, 1987Date of Patent: January 29, 1991Assignee: Daishowa Chemicals Inc.Inventors: Russell H. Samson, John W. Hollis, Jr.
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Patent number: 4946829Abstract: A process for the preparation of a low molecular weight alkali metal or ammonium huminate fraction comprising stirring an aqueous suspension of a humic containing material while adding an alkaline substance without exceeding a pH of 7, allowing the solids to settle from the suspension, centrifuging the solid free solution and subjecting the solution to ultrafiltration to obtain a low molecular weight alkali metal or ammonium huminate fraction and an improved method of healing wounds.Type: GrantFiled: May 13, 1988Date of Patent: August 7, 1990Assignee: Rutgerswerke AGInventors: Bernhard Seubert, Werner Fickert, Ulrich Spitaler