Publication number: 20020028821
Abstract: A compound of formula (I) wherein R1 is a group of formula G1, G2, G3, G4 or G5; R2 is hydrogen, (C1 C4 )alkyl, phenyl or naphthyl, wherein said phenyl or naphthyl may optionally be substituted with one or more substituents, preferably from zero to three substituents, independently selected from chloro, fluoro, bromo, iodo, (C1 C6 )alkyl, (C1 C6 )alkoxy, trifluoromethyl, cyano and SO g (C1 C6 )alkyl wherein g is zero, one or two; R3 is (CH2)m B, wherein m is zero, one, two or three and B is hydrogen, phenyl, naphthyl or a 5 or 6membered heteroaryl group containing from one to four hetero atoms in the ring (e.g., furyl, thienyl, pyridyl, pyrimidyl, thiazolyl, pyrazolyl, isothiazolyl, oxazolyl, isoxazolyl, pyrrolyl, triazolyl, tetrazolyl, imidazolyl, etc.), and wherein each of the foregoing aryl and heteroaryl groups may optionally be substituted with one or more substituents, preferably from zero to three substituents, independently selected from chloro.
Type:
Application
Filed:
September 24, 1998
Publication date:
March 7, 2002
Inventor:
HARRY R. HOWARD
Patent number: 6218394
Abstract: 4-Aryl-1-(indanmethyl, dihydrobenzofuramethyl or dihydrobenzothiophenemethyl) piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I)
wherein one of X and Y is CH2, and the other one is CH2, O or S; Z is N, C, CH or COH; Ar is an optionally substituted aryl group; R1 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, acyl, thioacyl, alkylsulfonyl, trifluoromethylsulfonyl, arylsulfonyl, a group R9VCO— where V is O or S and R9 is alkyl or aryl, or a group R10R11NCO— or R10R11NCS— wherein R10 and R11 are hydrogen, alkyl or aryl, or R10 and R11 are linked to form a ring; R2 is hydrogen, alkyl, cycloalkyl or cycloalkylalkyl; or R1 and R2 are linked to form a ring; R3-R5 are hydrogen, halogen, alkyl, alkylcarbonyl, phenylcarbonyl, alkoxy, alkylthio, hydroxy, alkylsulfonyl, cyano, trifluoromethyl, cycloalkyl, cycloalkylalkyl or nitro; R6 and R7 are hydrogen or alkyl or they are linked to constitute a 3-7-membered ring; R8 is hydrogen or alkyl
Type:
Grant
Filed:
December 9, 1996
Date of Patent:
April 17, 2001
Assignee:
H. Lundbeck A/S
Inventors:
Jens Kristian Perregaard, John Willie Stenberg, Bitten Hansen