Plural Isoquinoline Ring Systems Attached Directly Or Indirectly To Each Other By Nonionic Bonding Patents (Class 514/308)
  • Anti-hypertensive agents
    Patent number: 4690938
    Abstract: Novel inhibitors of ACE are disclosed as potent inhibitors of angiotensin converting enzyme and as orally effective anti-hypertensive agents.
    Type: Grant
    Filed: August 14, 1979
    Date of Patent: September 1, 1987
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung
  • Anti-hypertensive agents
    Patent number: 4690936
    Abstract: Novel inhibitors of angiotensin converting enzyme having the general formula R--A--S--Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.
    Type: Grant
    Filed: May 2, 1980
    Date of Patent: September 1, 1987
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung
  • Anti-hypertensive agents
    Patent number: 4690937
    Abstract: Novel inhibitors of ACE are disclosed as potent inhibitors of angiotensin converting enzyme and as orally effective anti-hypertensive agents.
    Type: Grant
    Filed: August 14, 1979
    Date of Patent: September 1, 1987
    Assignee: University of Miami
    Inventors: James W. Ryan, Alfred Chung
  • Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
    Patent number: 4634716
    Abstract: Compounds of the formula: ##STR1## where R.sup.3 is ##STR2## where n is 1-3 and the R.sup.a 's and R.sup.b 's are independently hydrogen or loweralkyl; and pharmaceutically acceptable salts thereof; are inhibitors or angiotensin I converting enzyme useful as antihypertensive agents.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: January 6, 1987
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, David Taub
  • Method of antagonizing the effects of thromboxane
    Patent number: 4536510
    Abstract: Methods of antagonizing the effects of thromboxane A.sub.2 in the circulatory system of an animal which comprises administering to said animal a nontoxic effective amount of N,N'-bis[7-(3-chlorobenzeneaminosulfonyl)-1,2,3,4-tetrahydroisoquinolyl]di sulfonylimide or a pharamaceutical acceptable salt thereof are valuable in the treatment of diseases in which thromboxane A.sub.2 is a factor, such as thrombosis, endotoxic shock and cardiac anaphylaxis.
    Type: Grant
    Filed: July 22, 1983
    Date of Patent: August 20, 1985
    Assignee: Smith Kline Beckman Corporation
    Inventors: Martin A. Wasserman, Barry M. Weichman