The Additional Hetero Ring Consists Of Two Nitrogens And Three Carbons Patents (Class 514/341)
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Publication number: 20140187541Abstract: The present invention provides a composition for controlling harmful arthropods having an excellent control efficacy on harmful arthropods. A composition for controlling harmful arthropods comprising a carboxylic acid compound represented by a formula (I); wherein each of symbols are the same as defined in the Description; or salts thereof and at least one kind of neonicotinoid compounds selected from the group (A) consisting of imidacloprid, clothianidin, thiamethoxiam, dinotefuran, acetamiprid, thiacloprid and nitenpyram, shows an excellent controlling efficacy on harmful arthropods.Type: ApplicationFiled: July 20, 2012Publication date: July 3, 2014Inventors: Atsushi Iwata, Chie Shimizu, MIki Suzuki
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Publication number: 20140179702Abstract: The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.Type: ApplicationFiled: October 15, 2013Publication date: June 26, 2014Inventors: Andreas Kling, Katja Jantos, Helmut Mack, Achim Möller, Wilfried Hornberger, Gisela Backfisch, Yanbin Lao, Marjoleen Nijsen
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Publication number: 20140179692Abstract: The present invention provides a composition for controlling harmful arthropods having an excellent control efficacy on harmful arthropods. A composition for controlling harmful arthropods comprising an amide compound represented by a formula (I); wherein each of symbols are the same as defined in the Description; or salts thereof and at least one kind of neonicotinoid compounds selected from the group (A) consisting of imidacloprid, clothianidin, thiamethoxiam, dinotefuran, acetamiprid, thiacloprid and nitenpyram, shows an excellent controlling efficacy on harmful arthropods.Type: ApplicationFiled: July 20, 2012Publication date: June 26, 2014Applicant: SUMITOMO CHEMICALCOMPANY, LIMITEDInventors: Atsushi Iwata, Chie Shimizu, Miki Suzuki
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Publication number: 20140179519Abstract: The present invention relates to N-thio-anthranilamide compounds of the formula (I), the stereoisomers, the salts, the tautomers and the N-oxides thereof, wherein R1 is halogen, methyl or halomethyl, R2 is hydrogen, halogen or cyano; R3 is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, C2-C6-alkenyl or the like; R4 is halogen; R5 and R6 independently of each other are optionally substituted C1-C6-alkyl, C3-C6-cycloalkyl, C2-C6-alkenyl, C2-C6-alkynyl, phenyl, or together represent an (hetero)aliphatic chain, or the like; and k is 0 or 1.Type: ApplicationFiled: August 10, 2012Publication date: June 26, 2014Applicant: BASF SEInventors: Florian Kaiser, Karsten Körber, Prashant Deshmukh, Deborah L. Culbertson, Paul Neese, Koshi Gunjima
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Publication number: 20140178349Abstract: A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein A represents a C3 to C12 cycloalkyl group which may be substituted by one to three selected from a fluoro group, a hydroxy group, a C1 to C6 alkyl group, etc; R1, R2, and R3 each independently represent a hydrogen atom, a fluoro group, or a C1 to C6 alkyl group; R4 represents a hydrogen atom or a prodrug group; and Y represents —CH2—CHR5—CH2—NHR6 (wherein R5 represents a hydrogen atom, a C1 to C6 alkyl group, or a C1 to C6 alkoxy group, and R6 represents a hydrogen atom or a prodrug group), or the like exhibits excellent TAFIa inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, and the like.Type: ApplicationFiled: December 16, 2013Publication date: June 26, 2014Applicant: Daiichi Sankyo Company, LimitedInventors: Tsutomu Nagata, Masahiro Inoue, Yuka Ashida, Kengo Noguchi, Makoto Ono
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Patent number: 8758788Abstract: Active compound mixtures comprising ipconazole and at least one further fungicidally active compound are highly suitable for protecting industrial materials against colonization and destruction by microorganisms.Type: GrantFiled: January 22, 2010Date of Patent: June 24, 2014Assignee: Bayer Intellectual Property GmbHInventors: Rainer Bruns, Martin Kugler, Thomas Jaetsch
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Patent number: 8759332Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral (particularly HCV) infection in a subject in need of such therapy with the compounds.Type: GrantFiled: September 10, 2010Date of Patent: June 24, 2014Assignee: Enanta Pharmaceuticals, Inc.Inventors: Yao-Ling Qiu, Ce Wang, Xiaowen Peng, Lu Ying, Yat Sun Or
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Publication number: 20140171469Abstract: Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor.Type: ApplicationFiled: July 3, 2013Publication date: June 19, 2014Applicant: Arena Pharmaceuticals, Inc.Inventors: Thuy-Anh Tran, Jason B. Ibarra, Young-Jun Shin, Brett Ullman, Ning Zou, Xi Zeng
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Publication number: 20140171426Abstract: The present invention provides a composition for controlling harmful arthropods having an excellent control efficacy on harmful arthropods. A composition for controlling harmful arthropods comprising an amide compound represented by a formula (I); wherein each of symbols are the same as defined in the Description; or salts thereof and at least one kind of neonicotinoid compounds selected from the group (A) consisting of imidacloprid, clothianidin, thiamethoxiam, dinotefuran, acetamiprid, thiacloprid and nitenpyram, shows an excellent controlling efficacy on harmful arthropods.Type: ApplicationFiled: July 20, 2012Publication date: June 19, 2014Inventors: Atsushi Iwata, Chie Shimizu, Miki Suzuki
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Patent number: 8754219Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.Type: GrantFiled: April 27, 2011Date of Patent: June 17, 2014Assignee: Calcimedica, Inc.Inventors: Jeffrey P. Whitten, Yazhong Pei, Jianguo Cao, Zhijun Wang, Evan Rogers, Brian Dyck, Jonathan Grey
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Publication number: 20140163031Abstract: The present invention relates to compounds of Formula (I), wherein X1, X2, X3, X4, R1, R2, R3, and Q are as defined herein, useful as N-type calcium channel blockers.Type: ApplicationFiled: August 16, 2013Publication date: June 12, 2014Applicant: Janssen Pharmaceutica NVInventors: Mark Wall, Nalin Subasinghe, Zhihua Sui
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Publication number: 20140162989Abstract: The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to binary phase compositions comprising one or more pharmaceutical entities and methods for producing such compositions.Type: ApplicationFiled: February 13, 2014Publication date: June 12, 2014Applicants: The Regents of the University of Michigan, University of South FloridaInventors: Michael J. Zaworotko, Nair Rodriguez-Hornedo, Brian Moulton
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Publication number: 20140163009Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.Type: ApplicationFiled: January 23, 2012Publication date: June 12, 2014Applicant: CHDI FoundationInventors: Christopher A Luckhurst, Alen F Haughan, Perla Breccia, Andrew J Stott, Roland W Burli, Samantha J Hughes, Ignacio Munoz-Sanjuan, Celia Dominguez
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Publication number: 20140163075Abstract: The invention relates to the field of 26S proteasome inhibition, activation and modulation and to identify compounds which activate 26S proteasome in live cells and a method of treating autoimmune diseases, cancer, inflammation and neurogenerative disorders by inhibition, activation and modulation of the 26S proteasome.Type: ApplicationFiled: June 1, 2012Publication date: June 12, 2014Applicant: NETHERLAND CANCER INSTITUTEInventors: Huib Ovaa, Celia R. Berkers, Yves Leestemaker, Karianne Shuurman, Annemieke De Jong
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Publication number: 20140162875Abstract: The present invention relates to N-thio-anthranilamide compounds and the stereoisomers, salts, tautomers and N-oxides thereof and to compositions comprising the same. The invention also relates to the use of the N-thio-anthranilamide compounds or of the compositions comprising such compounds for combating invertebrate pests. Furthermore, the invention relates to methods of applying such compounds.Type: ApplicationFiled: August 10, 2012Publication date: June 12, 2014Applicant: BASF SEInventors: Prashant Deshmukh, Karsten Körber, Joachim Dickhaut, Henricus Maria Martinus Bastiaans, Markus Kordes, Florian Kaiser, Arun Narine, Nina Gertrud Bandur, Gemma Veitch, Deborah L. Culbertson, Paul Neese, Koshi Gunjima
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Publication number: 20140163001Abstract: Provided is a heterocyclic compound having an ROR?t inhibitory activity.Type: ApplicationFiled: July 27, 2012Publication date: June 12, 2014Applicant: Takeda Pharmaceutical Company LimitedInventors: Satoshi Yamamoto, Junya Shirai, Atsuko Ochida, Yoshiyuki Fukase, Yoshihide Tomata, Ayumu Sato, Shotaro Miura, Kazuko Yonemori, Ryokichi Koyama
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Publication number: 20140163076Abstract: The present invention relates to the use of active substance combinations which consist firstly of known cyclic ketoenols and secondly of further known insecticidal active substances, for controlling animal pests from the stink bug family (Pentatomidae).Type: ApplicationFiled: February 18, 2014Publication date: June 12, 2014Applicant: Bayer CropScience AGInventors: Reiner Fischer, Konrad Kemper, Jürgen Kühnhold, Xavier Alain Marie Van Waetermeulen, Francisco Leonel Junior Lozano
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Publication number: 20140162874Abstract: This document discloses molecules having the following formula (“Formula One”): and processes related thereto.Type: ApplicationFiled: February 12, 2014Publication date: June 12, 2014Applicant: DOW AGROSCIENCES LLCInventors: Maurice C. Yap, Ann M. Buysse, Daniel Knueppel, Yu Zhang, Negar Garizi, Noormohamed M. Niyaz, Christian T. Lowe, Ricky Hunter, Tony K. Trullinger, David A. Demeter, Dan Pernich, Carl DeAmicis, Ronald Ross, JR., Timothy C. Johnson
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Patent number: 8748442Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.Type: GrantFiled: June 30, 2011Date of Patent: June 10, 2014Assignee: Ironwood Pharmaceuticals, Inc.Inventors: Charles Kim, Takashi Nakai, Thomas Wai-Ho Lee, Joel Moore, Nicholas Robert Perl, Jason Rohde, Rajesh R Iyengar, Ara Mermerian, Angelika Fretzen
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Patent number: 8748431Abstract: Compounds of the formula I Formula (I) wherein the substituents are as defined in claim 1, are useful as active ingredients, which have microbiocidal activity, in particular fungicidal activity.Type: GrantFiled: November 25, 2011Date of Patent: June 10, 2014Assignee: Syngenta Participations AGInventors: Sarah Sulzer-Mosse, Clemens Lamberth, Mathias Stephan Respondek, Laura Quaranta, Fredrik Cederbaum, Guillaume Berthon
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Publication number: 20140155436Abstract: The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly.Type: ApplicationFiled: November 4, 2013Publication date: June 5, 2014Applicants: CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE, UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, INSTITUT CURIEInventors: Jamal TAZI, David GRIERSON, Florence MAHUTEAU-BETZER, Pierre ROUX
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Publication number: 20140155264Abstract: The present invention relates to N-thio-anthranilamide compounds of the formula (I), the stereoisomers, the salts, the tautomers and the N-oxides thereof, wherein R1 is halogen or halomethyl; R2 is hydrogen, halogen or cyano; R3 is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, C2-C6-alkenyl or the like; R4 is halogen; R5 and R6 independently of each other are optionally substituted C1-C6-alkyl, C3-C6-cycloalkyl, C2-C6-alkenyl, C2-C6-alkynyl, phenyl, or together represent an (hetero)aliphatic chain, or the like; k is 0 or 1.Type: ApplicationFiled: August 10, 2012Publication date: June 5, 2014Applicant: BASF SEInventors: Florian Kaiser, Karsten Körber, Prashant Deshmukh, Deborah L. Culbertson, Paul Neese, Koshi Gunjima
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Publication number: 20140155407Abstract: The present invention relates to compounds which selectively inhibit CYP11B1. Preferably, the compounds of the present invention do not substantially inhibit CYP11B2. Moreover, the compounds of the present invention do not substantially inhibit CYP17 and/or CYP19, either. Amongst other applications of the compounds of the present invention, they can be used for the treatment of Cushing's syndrome or metabolic disease.Type: ApplicationFiled: October 21, 2011Publication date: June 5, 2014Inventors: Rolf Hartmann, Ulrike Hille, Christina Zimmer, Carsten A. Vock, Qingzhong Hu
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Publication number: 20140155410Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.Type: ApplicationFiled: February 6, 2014Publication date: June 5, 2014Applicant: GlaxoSmithKline LLCInventors: Jerry Leroy Adams, Thomas H. Faitg, Neil W. Johnson, Jiri Kasparec, Hong Lin, Mark Mellinger, Xin Peng, Ren Xie
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Patent number: 8742119Abstract: Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.Type: GrantFiled: October 6, 2011Date of Patent: June 3, 2014Assignee: Agios Pharmaceuticals, Inc.Inventors: Francesco G. Salituro, Jeffrey O. Saunders
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Patent number: 8741892Abstract: This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.Type: GrantFiled: November 30, 2012Date of Patent: June 3, 2014Assignee: Boehringer Ingelheim International GmbHInventors: Matthias Grauert, Daniel Bischoff, Georg Dahmann, Raimund Kuelzer, Klaus Rudolf, Bernd Wellenzohn
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Publication number: 20140148461Abstract: The present invention relates to compounds of the formula I and their salts etc. which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.Type: ApplicationFiled: November 22, 2013Publication date: May 29, 2014Inventors: Hervé GENESTE, Sean Colm TURNER, Michael OCHSE, Karla DRESCHER, Lawrence A. BLACK, Katja JANTOS
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Publication number: 20140148484Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof for use in the treatment or prevention of hairloss, wherein W, L1, L2, X, L3, Y, R1 and R2 have one of the meanings as indicated in the specification and claims, to pharmaceutical compositions containing said compounds or pharmaceutically acceptable salts thereof, to the use of said compounds or pharmaceutically acceptable salts thereof for the manufacture of a medicament useful for the treatment or prevention of hairloss, to a method of treating or preventing hairloss as well as to a method of stimulating hair growth.Type: ApplicationFiled: November 18, 2013Publication date: May 29, 2014Applicant: Boehringer Ingelheim International GmbHInventors: Andreas SCHNAPP, Jeffrey Adam ENCINAS, Andy FOWLER, Takeshi KONO, Katsuhiro UTO
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Publication number: 20140147691Abstract: The present invention relates to a preservative formulation for use in treating wood or other cellulosic materials, said formulation comprising: at least one biocidal metal compound; at least one preservative; and an aqueous carrier, wherein the preservative formulation has an uptake in the sapwood of less than about 220 l/m3 yet achieves substantially full penetration of the sapwood. Preferably, the preservative formulation is copper/tebuconazole in a ratio of about 25/1 w/w; and the wood is around 25 mm in thickness—for instance, decking timber.Type: ApplicationFiled: June 29, 2012Publication date: May 29, 2014Applicant: ARCH WOOD PROTECTION PTY LTDInventors: David Humphrey, Brett Skewes, Angelo Hrastov, Drago Bagaric, Peter Hausler, Shane McFarling, Greg Jensen, Steve Koch, Noel Koskela, Troy Justice
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Publication number: 20140148411Abstract: The present invention relates to pyrazole carboxamides derivatives of formula (1) wherein Y represents CR5 or N, T represents S or O, X1 and X2 represent a chlorine or a fluorine atom, and Z1 represents a substituted or non-substituted cyclopropyl; Their process of preparation, their use as fungicide, and/or anti-mycotoxin active agents, and/or insecticide, and/or nematicide, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.Type: ApplicationFiled: January 28, 2014Publication date: May 29, 2014Inventors: Guenter BARTELS, Angela BECKER, Juergen BENTING, Christoph-Andreas BRAUN, Peter DAHMEN, Philippe DESBORDES, Christophe DUBOST, Stephanie GARY, Ulrich GORGENS, Hiroyuki HADANO, Beniot HARTMANN, Thomas KNOBLOCH, Marc KOSTEN, Norbert LUI, Ruth MEISSNER, Sergiy PAZENOK, Rachel RAMA, Arnd VOERSTE, Ulrike WACHENDORFF-NEUMANN
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Publication number: 20140148471Abstract: The present application relates to novel heterocyclic compounds, to the use thereof for controlling animal pests, which include arthropods and especially insects, and to processes for preparing the novel compounds.Type: ApplicationFiled: January 31, 2014Publication date: May 29, 2014Applicant: Bayer CropScience AGInventors: Thomas BRETSCHNEIDER, Reiner FISCHER, Martin FÜßLEIN, Peter JESCHKE, Adeline KÖHLER, Joachim KLUTH, Friedrich August MÜHLTHAU, Yoshitaka SATO, Arnd VOERSTE, Eiichi SHIMOJO
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Publication number: 20140148448Abstract: The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.Type: ApplicationFiled: January 30, 2014Publication date: May 29, 2014Applicant: Janssen Pharmaceutica NVInventors: Carl R. ILLIG, Shelley K. BALLENTINE, Jinsheng CHEN, Renee Louise DESJARLAIS, Sanath K. MEEGALLA, Mark WALL, Kenneth WILSON
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Patent number: 8735431Abstract: The invention relates to novel insecticidal active compound combinations comprising, firstly, anthranilamides and, secondly, further insecticidally active compounds as defined in the description, which combinations are highly suitable for controlling animal pests, such as insects.Type: GrantFiled: November 20, 2004Date of Patent: May 27, 2014Assignee: Bayer CropScience AGInventors: Christian Funke, Reiner Fischer, Rüdiger Fischer, Heike Hungenberg, Wolfram Andersch, Wolfgang Thielert, Anton Kraus
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Publication number: 20140141977Abstract: The invention relates to suspension concentrates comprising a) one or more pesticides that are solid at room temperature, b) one or more specific copolymers, c) one or more additional auxiliary substances as applicable and d) one or more solvents. The copolymers b) comprise structural units of formula (I), wherein A stands for C2-C4-alkyls, B stands for a C2-C4-alkyl different from A, R stands for hydrogen or methyl, m is a number from 1 to 500, n is a number from 1 to 500, the sum of m+n is equal to 2 to 1000 and P stands for H or for a specific other concluding group, and structural units derived from specific ethylenic, unsaturated monomers that comprise an aromatic group, and structural units derived from specific ethylenic, unsaturated monomers that comprise aliphatic hydrocarbon residue. The suspension concentrates according to the invention are advantageously suitable for use as pesticides.Type: ApplicationFiled: March 10, 2012Publication date: May 22, 2014Applicant: CLARIANT FINANCE (BVI) LIMITEDInventors: Andreas Wacker, Carsten Schaefer, Alexander Woerndale, Robert Milbradt
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Publication number: 20140140973Abstract: This invention pertains to a method for controlling lepidopteran, homopteran, hemipteran, thysanopteran and coleopteran insect pests comprising contacting the insects or their environment with an arthropodicidally effective amount of a compound of Formula I, its N-oxide or an agriculturally suitable salt thereof wherein A and B and R1 through R8 are as defined in the disclosure. This invention further relates to a bezoxazinone compound of Formula 10 wherein R4 through R8 are as defined in the disclosure, useful for preparation of a compound of Formula I.Type: ApplicationFiled: January 27, 2014Publication date: May 22, 2014Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: GEORGE PHILIP LAHM, Stephen Frederick McCann, Kanu Maganbhai Patel, Thomas Paul Selby, Thomas Martin Stevenson
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Publication number: 20140142144Abstract: The invention belongs to the field of medicaments, and particularly relates to oxazolidinone compounds and their uses in the preparation of antibiotics. A technical problem to be solved by the invention is to provide new oxazolidinone compounds having the structure represented by Formula I. The oxazolidinone compounds of the invention, which are new compounds obtained through numerous screening, have significant antibacterial activity against bacteria such as drug-resistant staphylococcus aureus, fecal coliform bacteria, and streptococcus pneumoniae, while exhibiting low toxicity. The invention provides new options for the development and application of antibiotics.Type: ApplicationFiled: June 15, 2012Publication date: May 22, 2014Applicants: SI CHUAN UNIVERSITY, SICHUAN GOODDOCTOR PHARMACEUTICAL GROUP CO., LTDInventors: Youfu Luo, Zhenling Wang, Yuquan Wei, Funeng Geng
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Publication number: 20140142143Abstract: The invention relates to substituted phenylureas and phenylamides, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.Type: ApplicationFiled: October 24, 2013Publication date: May 22, 2014Applicant: Gruenenthal GmbHInventors: Robert FRANK, Gregor BAHRENBERG, Thomas CHRISTOPH, Klaus SCHIENE, Jean DE VRY, Nils DAMANN, Sven FRORMANN, Bernhard LESCH, Jeewoo LEE, Yong-Soo KIM, Myeong-Seop KIM, Derek SAUNDERS, Hannelore STOCKHAUSEN
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Publication number: 20140141972Abstract: This invention pertains to methods for protecting a propagule or a plant grown therefrom from invertebrate pests comprising contacting the propagule or the locus of the propagule with a biologically effective amount of a compound of Formula I, its N-oxide or an agriculturally suitable salt thereof wherein A and B and R1 through R8 are as defined in the disclosure. This invention also relates to propagules treated with a compound of Formula I and compositions comprising a Formula I compound for coating propagules.Type: ApplicationFiled: January 27, 2014Publication date: May 22, 2014Applicant: E I DU PONT NEMOURS AND COMPANYInventors: RICHARD ALAN BERGER, Isaac Billy Annan, George Philip Lahm, John Lindsey Flexner, Thomas Paul Selby, Thomas Martin Stevenson
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Patent number: 8729105Abstract: The present invention relates to compounds of the formula wherein A1, A2, A3 and R1 to R8 are defined in the description, and to pharmaceutically acceptable salts thereof, their manufacture, pharmaceutical compositions containing them and their use as medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as particularly dyslipidemia, atherosclerosis and cardiovascular diseases.Type: GrantFiled: September 7, 2011Date of Patent: May 20, 2014Assignee: Hoffmann La-Roche Inc.Inventors: Paul Hebeisen, Hugues Matile, Stephan Roever, Matthew Wright, Sannah Zoffmann Jensen
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Patent number: 8729106Abstract: A pesticidal composition comprising synergistically effective amounts of at least one anthranilamide compound represented by the formula (I) or its salt and other pesticide: wherein each of R1a and R1b which are independent of each other, is halogen; each of R2 and R3 is halogen, alkyl, haloalkyl, alkoxy, haloalkoxy or cyano; A is alkyl substituted by Y; Y is C3-4 cycloalkyl which may be substituted by at least one substituent selected from the group consisting of halogen, alkyl and haloalkyl; n is 0 or 1; and q is an integer of from 0 to 4; provided that R1a and R1b are not simultaneously chlorine nor bromine.Type: GrantFiled: December 12, 2007Date of Patent: May 20, 2014Assignee: Ishihara Sangyo Kaisha, Ltd.Inventors: Toru Koyanagi, Masayuki Morita, Tetsuo Yoneda, Tsuyoshi Ueda, Kazuhisa Kiriyama, Taku Hamamoto
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Patent number: 8729077Abstract: Disclosed are compounds, stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, their preparation, use, and compositions thereof for treating an infection mediated at least in part by a virus in the Flaviviridae family of viruses.Type: GrantFiled: November 19, 2009Date of Patent: May 20, 2014Assignee: GlaxoSmithKline LLCInventors: Frank Ulrich Schmitz, Roopa Rai, Christopher Don Roberts, Wieslaw Kazmierski, Richard Grimes
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Patent number: 8729271Abstract: The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.Type: GrantFiled: September 16, 2011Date of Patent: May 20, 2014Assignee: Taisho Pharmaceutical Co., LtdInventors: Minoru Moriya, Akito Yasuhara, Kazunari Sakagami, Hiroshi Ohta, Kumi Abe, Shuji Yamamoto, Yuko Araki, Hiroki Urabe, Xiang-Min Sun
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Patent number: 8729101Abstract: The present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these compounds as an active component. These 1H-imidazole derivatives are potent cannabinoid-CB1 receptor agonists, partial agonists or antagonists, useful for the treatment of psychiatric and neurological disorders, as well as and other diseases involving cannabinoid neurotransmission. The compounds have the general formula (I), wherein R and R1-R4 have the meanings given in the specification.Type: GrantFiled: September 2, 2008Date of Patent: May 20, 2014Assignee: Solvay Pharmaceuticals, B.V.Inventors: Cornelis G. Kruse, Josephus H. M. Lange, Arnoldus H. J. Herremans, Herman H. Van Stuivenberg
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Publication number: 20140134262Abstract: The present invention provides a compound of Formula I: for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride level; wherein R1, X1, R7, R5, C, L and p are defined herein. The present invention further provides a combination of pharmacologically active agents for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride levels.Type: ApplicationFiled: July 6, 2012Publication date: May 15, 2014Inventors: Yoshie Arai, Margaret Elizabeth Brousseau, Jessie Gu, Tomoko Hayashi, Hironobu Mitani, Muneto Mogi, Kazuhiko Nonomura, Ken Yamada
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Publication number: 20140135346Abstract: The present application relates to novel amides and thioamides, to processes for preparation thereof and to the use thereof for controlling animal pests, in particular arthropods and especially insects.Type: ApplicationFiled: January 16, 2014Publication date: May 15, 2014Applicant: Bayer CropScience AGInventors: Thomas BRETSCHNEIDER, Adeline KÖHLER, Reiner FISCHER, Martin FÜßLEIN, Peter JESCHKE, Joachim KLUTH, Friedrich August MÜHLTHAU, Arnd VOERSTE, Olga MALSAM, Ulrich GÖRGENS, Yoshitaka SATO
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Publication number: 20140135218Abstract: This document discloses molecules having the following formula (Formula One) and processes related thereto.Type: ApplicationFiled: January 17, 2014Publication date: May 15, 2014Applicant: DOW AGROSCIENCES LLCInventors: Negar Garizi, Maurice C. Yap, Tony K. Trullinger, CaSandra L. McLeod, Paul R. LePlae, JR., Timothy C. Johnson, Ricky Hunter, John F. Daeuble, SR., Ann M. Buysse
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Publication number: 20140135301Abstract: Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.Type: ApplicationFiled: January 22, 2014Publication date: May 15, 2014Applicant: Chiesi Farmaceutici S.p.A.Inventors: Maurizio Delcanale, Elisabetta Armani, Gabriele Amari
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Patent number: 8722709Abstract: Mineralocorticoid receptor antagonists, of which the following is exemplary.Type: GrantFiled: November 7, 2011Date of Patent: May 13, 2014Assignee: Boehringer Ingelheim International GmbHInventors: Xin Guo, Stephen J. Boyer, Di Wu, Frank Wu
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Patent number: 8722695Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy.Type: GrantFiled: December 6, 2010Date of Patent: May 13, 2014Assignee: Autifony Therapeutics LimitedInventors: Giuseppe Alvaro, Anne Décor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
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Publication number: 20140128434Abstract: This invention relates to a method of treating cancer in a human in need thereof by determining the presence or absence of a detectable amount of a gene product of the Neurofibromin-2 (NF2) gene in a sample from the human, and administering to the human an effective amount of a focal adhesion kinase (FAK) inhibitor, or a pharmaceutically acceptable salt thereof, if no gene product or no isoform 1 gene product is detected. This invention also relates to a method of treating cancer in a human in need thereof, comprising determining the presence or absence of a detectable amount of a functional isoform 1 protein of the NF2 gene, or a functional fragment thereof, in a sample from the human, and administering to the human an effective amount of a focal adhesion kinase (FAK) inhibitor, or a pharmaceutically acceptable salt thereof, if no gene product or no isoform 1 gene product is detected.Type: ApplicationFiled: June 28, 2012Publication date: May 8, 2014Inventors: Kurt R. Auger, Mohammed M. Dar, Ronald A. Fleming