The Ring Nitrogen Of The Six-membered Hetero Ring Is Pentavalent (e.g., Quaternary Pyridinium Salt, Etc.) Patents (Class 514/358)
-
Publication number: 20130123308Abstract: A method for trapping, and neutralizing or killing microorganisms on a surface includes applying a barrier-forming composition that comprises an antimicrobial agent onto an inanimate surface, forming a barrier layer on the inanimate surface, in the barrier, trapping and killing microorganisms encountered on the surface and encountered from the environment after the applying step is performed. A composition for performing the method is also included. The dual-action of trapping and killing produces a barrier layer that has a powerful and long-lasting antimicrobial cidal or static activity. Compositions and methods are also included that have odor inhibiting activity and with activity to improve visual appearance of surfaces with microbial growth or discoloration.Type: ApplicationFiled: January 4, 2013Publication date: May 16, 2013Applicant: Oasis Consumer Healthcare, LLCInventor: Oasis Consumer Healthcare, LLC
-
Publication number: 20130102576Abstract: Compounds, pyridine N-oxides, and pharmaceutically acceptable salts of formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and for preventing and/or treating diseases of the respiratory tract characterized by airway obstruction, such as asthma or COPD.Type: ApplicationFiled: October 19, 2012Publication date: April 25, 2013Applicant: Chiesi Farmaceutici S.p.A.Inventor: Chiesi Farmaceutici S.p.A.
-
Publication number: 20130079313Abstract: The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.Type: ApplicationFiled: September 26, 2012Publication date: March 28, 2013Applicant: Chiesi Farmaceutici S.p.A.Inventor: Chiesi Farmaceutici S.p.A.
-
Publication number: 20130060208Abstract: The present invention relates to wound care products, devices and methods incorporating acetic acid for the treatment of bacterial infections, in particular bacterial biofilm infections. In particular it relates to a wound care product comprising acetic acid, wherein the product comprises at least one further antibacterial compound; a delivery system comprising a container connected to a means of delivery which is connected to a pad, wherein said container comprises a composition comprising acetic acid and said pad comprises a self-adhesive material; a kit comprising a dressing and an adhesive membrane, wherein the dressing comprises a composition comprising acetic acid; a method of treating a wound comprising a) applying acetic acid to the wound and b) applying a negative pressure to the wound.Type: ApplicationFiled: December 21, 2010Publication date: March 7, 2013Applicants: RIGSHOSPITALET, COPENHAGEN UNIVERSITY HOSPITAL, BISPEBJERG HOSPITAL, DANMARKS TEKNISKE UNIVERSITETInventors: Michael Christian Givskov, Thomas Bjarnsholt, Klaus Kirketerp-Møller
-
Patent number: 8377972Abstract: The invention relates to a method for the treatment or prevention of diseases or conditions associated with vascular endothelium dysfunction or liver injury comprising the administration to a patient in a need of such treatment or prevention of a therapeutically or prophylactically effective amount of a compound selected from the group consisting of: wherein R represents hydrogen atom, CH3, OH, pyridyl (C5H4N), 1-methylpyridyl (C5H4N—CH3) or pyridyl substituted with hydroxy group ((OH)C5H3N), and X represents a physiologically acceptable counterion.Type: GrantFiled: January 21, 2011Date of Patent: February 19, 2013Assignee: Trigendo Sp. zo.o.Inventors: Andrzej Marcinek, Stefan Chłopicki, Jerzy Gȩbicki, Jan Adamus
-
Publication number: 20130039959Abstract: A method for blocking, neutralizing, or killing human immunodeficiency virus (HIV) beginning prior to or during a human encountering an HIV contaminated environment or item includes: identifying a contaminated environment or item that is known or expected to be contaminated with HIV; and administering an effective amount of a barrier-forming composition to an oral or pharyngeal mucosa of the human prior to or during the human encountering the contaminated environment or item. The barrier-forming composition provides a barrier on the mucosa that inhibits the HIV from contacting the mucosa, and provides cidal or static activity against HIV. A method for preventing the transmission of HIV through oral sexual relations, and a sexually transmitted disease prophylactic device are also provided.Type: ApplicationFiled: October 18, 2012Publication date: February 14, 2013Inventors: Brian Vincent Sokol, Afif Mahmoud Ghannoum
-
Publication number: 20130028848Abstract: A method for blocking, neutralizing, or killing microorganisms that cause infectious disease in a mammal prior to or during the mammal encountering a contaminated environment or item includes: identifying a contaminated environment or item, wherein the contaminated environment or item is known or expected to be contaminated with harmful viral, fungal, or bacterial microorganisms; and administering a therapeutically effective amount of a barrier-forming composition to a mucosa of the mammal prior to or during the mammal encountering the contaminated environment or item. The barrier-forming composition provides a barrier on the mucosa that inhibits the microorganisms from contacting the mucosa. Other related methods are also included.Type: ApplicationFiled: April 17, 2012Publication date: January 31, 2013Inventors: Brian Vincent Sokol, Afif Mahmoud Ghannoum
-
Publication number: 20130004586Abstract: Compositions, solid polymeric compositions, and/or articles of manufacture are provided that can include a polymer matrix having a plurality of ion-exchange particles distributed therein. Products by process are provided that can include prior to solidifying the polymeric precursors, blending the precursors with ion-exchange particles to form a mixture, and solidifying the mixture to form a solid polymeric composition product. Solid polymeric composition production methods are also provided that can include providing a plurality of ion-exchange particles, prior to solidifying the polymeric precursors, blending the precursors with the ion-exchange particles to form a mixture, and solidifying the mixture to form a solid polymeric composition. Article of manufacture production methods are provided that can include incorporating a solid polymeric composition into an article of manufacture, the solid polymeric composition including a polymer matrix and a plurality of ion-exchange particles distributed therein.Type: ApplicationFiled: June 25, 2012Publication date: January 3, 2013Inventors: David J. Vachon, Nathan Knapp
-
Publication number: 20120316259Abstract: This invention relates to a process for the co-encapsulation of biocidally active ingredients in a clay mineral, the process comprising the step of bringing the clay mineral into contact with a biocidally active nitrogen compound that contains at least one hydrocarbon group with 6 to 20 carbon atoms, and at the same time or subsequently with at least one biocidally active compound selected from the group consisting of 2-n-octyl-4-isothiazoline-3-one, 3-iodopropenylbutyl-carbamate and tetrahis(hydroxymethyl)phosphonium sulfate. And the use of such encapsulated product in water based paints, coatings and varnishes.Type: ApplicationFiled: February 15, 2011Publication date: December 13, 2012Applicant: CLARIANT S.A. BRAZILInventors: Antonio Pedro de Oliveira Filho, Wagner Claudio Da Silva, Manlio Gallotti, Alexandra Paschoalin Menezes, Karine Framesqui Righi, Marcia Regina Da Silva Rios
-
Patent number: 8323673Abstract: A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is useful on food products to prevent microbial growth on the food from a broad spectrum of foodborne microbial contamination. Also disclosed is a method of contacting food products with the dilute QAC for an application time of at least 0.1 second. Foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be 10 treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.Type: GrantFiled: November 4, 2011Date of Patent: December 4, 2012Assignee: University of ArkansasInventors: Cesar Compadre, Philip Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg
-
Publication number: 20120295940Abstract: The present disclosure relates to compositions that are effective in controlling or in preventing mastitis in an domesticated animal. The disclosed compositions comprise a biocidal system, comprising a primary biocide and a pH buffer component; a skin conditioner and moisturizer; a cationic or ionic surfactant having an HLB of from about 5 to about 30; an emollient system comprising an extradermal penetrating agent and an emollient base; a thickening agent; and an aqueous based carrier.Type: ApplicationFiled: November 14, 2011Publication date: November 22, 2012Applicant: Noble Ion, LLCInventors: Burt R. Sookram, John W. Veenstra
-
Publication number: 20120288566Abstract: The present invention discloses liquid precursor compositions adapted for application on a hard surface in the oral cavity, comprising at least one therapeutic agent suitable for the treatment of oral disorders, at least one acidic-pH sensitive polymer, at least one hydrophobic polymer, and a pharmaceutically acceptable volatile carrier, wherein a weight ratio between said at least one hydrophobic polymer and said at least one acidic-pH sensitive polymer is larger than 1. The invention also discloses formulations formed of the solidification of these compositions, and methods for treating oral disorders by applying these compositions on hard surfaces in the oral cavity or to be placed in the oral cavity.Type: ApplicationFiled: October 5, 2010Publication date: November 15, 2012Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventors: Michael Friedman, Doron Steinberg, Irith Gati
-
Publication number: 20120288488Abstract: Compositions and methods for preventing or controlling bacteria, viruses and parasitic growths that cause diarrhea, pneumonia and septicemia in animals comprising a biocidal system comprised of a primary biocide and a pH buffer component; a cationic or ionic surfactant having an HLB of from about 5 to about 30; a thickening agent; and an aqueous based carrier.Type: ApplicationFiled: January 9, 2012Publication date: November 15, 2012Applicant: NOBLE ION, LLCInventors: Burt R. Sookram, John W. Veenstra
-
Patent number: 8304439Abstract: A method for the treatment or prevention of a cell or tissue damage in a living subject due to the exposure to ionizing radiation is provided, which comprises administration to said subject of a compound of formula (I) wherein R? is H, OH, CONH2 or COCH3, R? is H or CH3, R?? is H or CH3, and X? is a pharmaceutically acceptable counterion, in an amount sufficient to inhibit radiation-induced damage.Type: GrantFiled: October 9, 2008Date of Patent: November 6, 2012Assignees: Politechnika Lodzka, Uniwersylet JagiellonskiInventors: Jerzy Gebicki, Andrzej Marcinek, Stefan Chlopicki, Marek K. Janiak
-
Patent number: 8299253Abstract: Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse and or gastrointestinal tract disorders.Type: GrantFiled: December 22, 2006Date of Patent: October 30, 2012Assignee: University of Kentucky Research FoundationInventors: Peter Crooks, Linda Dwoskin, Roger Papke, Guangrong Zheng, Sangeetha P Sumithran
-
Publication number: 20120270909Abstract: In an embodiment, the barrier-forming composition includes a carbohydrate gum, a humectant, and an antimicrobial agent. The composition furthermore meets the following requirements: about 0.01%?C?about 0.4%; about 4.5%?H?about 65%; and 0.050%<A; or about 0%?C?about 0.4%; about 55%?H?about 65%; and 0.050%<A. C is the carbohydrate gum; H is the humectant; and A is the antimicrobial agent. All percentages are by weight of the total composition. In an embodiment the barrier-forming composition has an Rf value in water of 0 to about 0.25.Type: ApplicationFiled: April 17, 2012Publication date: October 25, 2012Inventors: Brian Vincent Sokol, Afif Mahmoud Ghannoum
-
Publication number: 20120251464Abstract: Compounds are described that are effective in enhancing the efficacy of antimicrobial agents. Also described are methods of using such compounds and compositions that include such compounds. The composition includes a chalcone compound and, optionally, an antimicrobial agent.Type: ApplicationFiled: December 18, 2009Publication date: October 4, 2012Applicants: Indian Institute of Integrative Medicine, Colgate-Palmolive ComplanyInventors: Ravi Subramanyam, Laurence Du-Thumm, Ghulam Nabi Qazi, Inshad Ali Khan, Krishan Avtar Suri, Naresh Kumar Satti, Furqan Ali, Nitin Pal Kalia
-
Publication number: 20120213832Abstract: A dental curable composition comprises (A) a polymerizable monomer and (B) an organic amine-based polymerization initiator, wherein (A?) a long-chain polymerizable monomer having a chain length of 17 or more atoms is contained in the component (A) and/or (C) a soft resin material are/is contained in the composition, and when the amount (parts by weight) based on 100 parts by weight of the component (A) of the component (A?) is represented by [a?] and the amounts (parts by weight) based on 100 parts by weight of the total of the components (A) and (B) of the components (A), (B) and (C) are represented by (a), (b) and (c), respectively, 70?(a)?99.99, 0.01?(b)?5 30, 1?[a?]/5+(c)/1, 0?[a?]?95, and 0?(c)?250.Type: ApplicationFiled: October 22, 2010Publication date: August 23, 2012Inventors: Tatsuya Ori, Haruka Nishitani, Sayuri Iwasaki, Yuya Yamamoto, Chidzuru Nishimoto
-
Publication number: 20120190715Abstract: Compositions and methods for treating disordered tissues, such as caused by pathogens and/or by toxins. The treatment compositions include an anti-infective active agent, a liquid carrier, and benzocaine in an amount so that the treatment composition penetrates more quickly into disordered tissue compared to the treatment composition in the absence of the benzocaine. In addition, the benzocaine can increase residence time of the anti-infective active in the treatment area. The preferred anti-infective active agent can be an organohalide, such as a quaternary ammonium halide compound, an example of which is benzalkonium chloride. The treatment compositions and methods may employ the use of an applicator adapted for use in promoting penetration of the treatment composition and/or agitation of the disordered tissue to further enhance penetration.Type: ApplicationFiled: January 24, 2011Publication date: July 26, 2012Inventors: B. Ron Johnson, James P. McCarthy
-
Publication number: 20120177712Abstract: This invention relates to a bipolar antimicrobial particle for use in laundry detergent compositions, fabric conditioners, personal care and cosmetic compositions and a process for making the same. In view of the foregoing, it is an object of the present invention to provide a stabile antimicrobial agent immobilised on a carrier particle. It is a further objective to provide an antimicrobial particle with improved retention to the fabric so that larger amounts of antimicrobial will be available even after rinsing. Surprisingly it has been found that antimicrobial molecules tagged by surface reaction onto naturally occurring asymmetric clay surfaces, act as an antimicrobial particle with improved retention properties with improved stability.Type: ApplicationFiled: August 30, 2010Publication date: July 12, 2012Inventors: Arpita Bhattacharya, Sudipta Ghosh Dastidar, Vidula Iyer, Suresh Sambamurthy Jayaraman, Maya Treesa Saji
-
Publication number: 20120178769Abstract: The present invention discloses novel compounds for inhibiting eEF2 kinase and methods of use thereof.Type: ApplicationFiled: July 15, 2010Publication date: July 12, 2012Applicant: The University of Medicine and DentistryInventor: Alexey G. Ryazanov
-
Patent number: 8211896Abstract: Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.Type: GrantFiled: October 1, 2010Date of Patent: July 3, 2012Assignee: Chemocentryx, Inc.Inventors: Solomon Ungashe, Zheng Wei, J. J. Wright, Andrew Pennell
-
Publication number: 20120121724Abstract: The present invention is related to the composition and methods of manufacture of orally-dissolvable, edible films as a vehicle for the non-invasive administration of nitroglycerin, as well as other therapeutic agents either with or without nitroglycerin, through the mucosal tissues of the oral cavity. The films include a water soluble film-forming polymer such as pullulan. Methods for producing the films are also disclosed.Type: ApplicationFiled: January 20, 2012Publication date: May 17, 2012Inventor: Todd Maibach
-
Publication number: 20120121723Abstract: An antimicrobial composition, including a synergistic combination of three or more agents as an active ingredient. Each of the three or more potentiating agents can be selected from the following types of compounds: sequestering agents, carbohydrates and carbohydrate derivatives, terpenes/terpenoids, amines and amine derivatives, plant-derived oils, sulfonates, phenols, fatty acids, dibenzofuran derivatives, organo isothiocyanates, quaternary ammonium compounds, peroxides and peroxide donors, and macrolide polyenes. At least two of the three or more potentiating agents are not of the same type of compound. The antimicrobial composition can have strong antimicrobial efficacy in control of microorganisms having resistance to currently used antimicrobials.Type: ApplicationFiled: January 25, 2012Publication date: May 17, 2012Applicant: Sterilex Technologies, LLCInventors: Pradip Mookerjee, Shira Kramer, Alexander Josowitz, April Zambelli-Weiner
-
Publication number: 20120071521Abstract: A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is useful on food products to prevent microbial growth on the food from a broad spectrum of foodborne microbial contamination. Also disclosed is a method of contacting food products with the dilute QAC for an application time of at least 0.1 second. Foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be 10 treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.Type: ApplicationFiled: November 4, 2011Publication date: March 22, 2012Inventors: Cesar COMPADRE, Philip Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg
-
Publication number: 20120052026Abstract: Antiplaque oral compositions are provided that contain an orally acceptable carrier and an antibacterial effective amount of the compound of formula (I). In various embodiments, the compositions contain from about 0.001% to about 10% by weight of the compound of formula (I).Type: ApplicationFiled: November 9, 2011Publication date: March 1, 2012Applicant: COLGATE-PALMOLIVE COMPANYInventors: Ravi Subramanyam, Prem Sreenivasan
-
Patent number: 8124631Abstract: The invention is directed to a method for enhancing prostacyclin levels in a mammal in need thereof, wherein the method includes administering a quaternary pyridinium salt of formula (I), wherein R is NH2, CH3, or N(H)CH2OH group, and X is pharmaceutically acceptable counterion.Type: GrantFiled: January 11, 2010Date of Patent: February 28, 2012Assignee: Pharmena Spolka Akcyjna (Pharmena S.A.)Inventors: Jerzy Gebicki, Stefan Chlopicki
-
Publication number: 20120034290Abstract: The present invention relates to quaternary ammonium salts and their use as mold inhibitors. The quaternary salts can be prepared by a chloride ion-promoted reaction between a tertiary amine and an alcohol or polyol in strong acid solution. The quaternary ammonium salts can be applied to a substrate in order to impart anti-mold properties to the substrate. Preferably, the quaternary ammonium salt compounds are applied to paper substrates in an amount of about 1000 ppm. Preferably, the quaternary ammonium salts compounds are applied as mixtures of more than one quaternary ammonium salt compound. The treated substrate does not require encapsulators, binders, or retention aids.Type: ApplicationFiled: August 29, 2007Publication date: February 9, 2012Inventors: Maurice C. Kemp, David E. Lewis
-
Publication number: 20110288014Abstract: The present invention relates to methods and compositions for preventing or treating diabetes. The invention in particular discloses compounds according to formula (I) for use in the prevention and treatment of type II or I diabetes.Type: ApplicationFiled: November 17, 2009Publication date: November 24, 2011Applicant: TUM Technische Universitat MunchenInventors: Thomas Hofmann, Sandra Held, Roman Lang, Veronika Somoza
-
Publication number: 20110281002Abstract: Disclosed are antimicrobial compositions for treating poultry, meat, and other surfaces to substantially eliminate bacteria and microorganism harmful to humans. The compositions include a combination of an aliphatic heteroaryl salt, trichloromelamine, and at least two ammonium salts comprising an aliphatic benzylalkyl ammonium salt, dialiphatic dialkyl ammonium salt, or a tetraalkyl ammonium salt.Type: ApplicationFiled: April 3, 2009Publication date: November 17, 2011Inventors: Steve R. Burwell, Fred Busch
-
Patent number: 8017613Abstract: The present invention relates to new compounds, ligands of the beta-3 adrenergic receptor, their preparation and their use in therapy or as research tools for said receptor; the invention also relates to a process for the preparation of the compounds of the invention and the use of inverse agonists of the beta-3 adrenergic receptor as medicaments.Type: GrantFiled: August 3, 2007Date of Patent: September 13, 2011Assignee: Universita' Degli Studi Di BariInventors: Antonio Scilimati, Maria Grazia Perrone, Ernesto Santandrea
-
Publication number: 20110201653Abstract: The invention relates to a method for inhibiting and/or preventing formation of cancer metastases and secondary malignant cancers by administration to a subject of an effective amount of a quaternary pyridinium salt of formula I wherein R? is selected from the group consisting of H, OH, CONH2, COCH3, R? is selected from the group consisting of H, CH3, R?? represents H or CH3, and X? is a pharmaceutically acceptable counterion.Type: ApplicationFiled: April 26, 2011Publication date: August 18, 2011Inventors: Jerzy Gebicki, Andrzej Marcinek, Stefan Chlopicki
-
Publication number: 20110160123Abstract: Provided herein are methods of reducing drug resistance in Mycobacterium tuberculosis (Mtb). The methods comprise contacting the Mtb with an agent, wherein the agent inhibits the activity of an efflux complex. Also provided are methods of treating Mtb in a subject. The methods comprise administering to the subject an agent that inhibits the activity of an efflux complex; and administering to the subject a tuberculosis treating agent. Further provided is a method of screening for an agent that reduces drug resistance in Mtb. The methods comprise providing an Mtb with a mutant efflux complex; and contacting Mtb with an agent to be tested and a tuberculosis treating agent.Type: ApplicationFiled: May 20, 2009Publication date: June 30, 2011Applicant: THE UAB RESEARCH FOUNDATIONInventor: Michael Niederweis
-
Publication number: 20110144070Abstract: Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.Type: ApplicationFiled: February 22, 2011Publication date: June 16, 2011Applicant: Chiesi Farmaceutici S.p.A.Inventors: Maurizio Delcanale, Elisabetta Armani, Gabriele Amari
-
Publication number: 20110118316Abstract: The invention relates to a method for the treatment or prevention of diseases or conditions associated with vascular endothelium dysfunction or liver injury comprising the administration to a patient in a need of such treatment or prevention of a therapeutically or prophylactically effective amount of a compound selected from the group consisting of: wherein R represents hydrogen atom, CH3, OH, pyridyl (C5H4N), 1-methylpyridyl (C5H4N—CH3) or pyridyl substituted with hydroxy group ((OH)C5H3N), and X represents a physiologically acceptable counterion.Type: ApplicationFiled: January 21, 2011Publication date: May 19, 2011Applicant: TRIGENDO sp. z o.o.Inventors: Andrzej MARCINEK, Stefan Chlopicki, Jerzy Gebicki, Jan Adamus
-
Publication number: 20110105406Abstract: The present invention relates to a cosmetic composition comprising: a) from about 0.05% to about 10% of a salt form active; b) from about 0.001% to about 2% of a thickening agent; and c) water, wherein the composition has a turbidity no higher than about 10 NTU, and has a pH in the range of about 5.0 to about 6.8.Type: ApplicationFiled: October 29, 2010Publication date: May 5, 2011Applicant: The Proctor & Gamble CompanyInventors: Chengwu Li, Xincheng Hu
-
Patent number: 7935717Abstract: The invention is directed to a method for treating hypertriglyceridemia, dyslipidemia and hypercholesterolemia by administration of a 1-methylnicotinamide salt.Type: GrantFiled: January 7, 2005Date of Patent: May 3, 2011Assignee: Pharmena Spolka Akcyjna (Pharmena S.A.)Inventors: Jerzy Gebicki, Stefan Chlopicki
-
Publication number: 20110091556Abstract: The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs. In particular, decreased pathogenic organism infectivity, morbidity, and mortality is accomplished by contacting the pathogenic organism with an oil-in-water nanoemulsion comprising an oil, an organic solvent, and a surfactant dispersed in an aqueous phase.Type: ApplicationFiled: August 18, 2006Publication date: April 21, 2011Inventors: James R. Baker, JR., Tarek Hamouda, Amy Shih, Andrzej Myc
-
Publication number: 20110071099Abstract: The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.Type: ApplicationFiled: October 31, 2005Publication date: March 24, 2011Inventors: Alicja Bielawska, Zdzislaw M. Szuic, Yusuf A. Hannun, Lina M. Obeid, Besim Ogretmen
-
Patent number: 7893094Abstract: The present invention is directed to the amphiphilic pyridinium compounds, such as for suppressing IL-8 secretion and production. The present invention further provides methods of making and using such compounds for the treatment of the IL-8 related diseases, such as cystic fibrosis.Type: GrantFiled: June 28, 2004Date of Patent: February 22, 2011Assignees: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., National Institutes of Health (NIH)Inventors: Harvey B. Pollard, Kenneth Jacobson
-
Patent number: 7893095Abstract: The invention relates to a method for the treatment or prevention of diseases or conditions associated with vascular endothelium dysfunction or liver injury comprising the administration to a patient in a need of such treatment or prevention of a therapeutically or prophylactically effective amount of a compound selected from the group consisting of: wherein R represents hydrogen atom, CH3, OH, pyridyl (C5H4N), 1-methylpyridyl (C5H4N—CH3) or pyridyl substituted with hydroxy group ((OH)C5H3N), and X represents a physiologically acceptable counterion.Type: GrantFiled: February 27, 2008Date of Patent: February 22, 2011Assignee: TRIGENDO sp. z o.o.Inventors: Andrzej Marcinek, Stefan ChŁopicki, Jerzy GĘbicki, Jan Adamus
-
Publication number: 20100305169Abstract: A personal-care composition in the form of an oil-in-water emulsion comprises a water phase, an oil phase, an anionic pairing agent, a cationic active, and an anionic thickener. In one embodiment, the anionic pairing agent is pre-formed from the neutralization of an acid with a base. In another embodiment, the anionic pairing agent is formed in situ from the neutralization of an acid with a base. At least 25% by weight of the cationic active is present in the oil phase. In certain embodiments, a method for regulating keratinous tissue condition and a method for improving deliverability of a cationic active in the presence of an anionic thickener comprise the steps of: providing the aforementioned personal-care composition, and applying the composition to keratinous tissue in need of treatment. The personal-care composition allows for previously unattainable levels of the cationic active to locate within the oil phase of the emulsion.Type: ApplicationFiled: March 23, 2010Publication date: December 2, 2010Inventors: Larry Rich Robinson, Gary Robert Kelm, Denver Michael Faulk
-
Publication number: 20100305168Abstract: In one embodiment, a personal-care composition in the form of an oil-in-water emulsion comprises an anionic pairing agent, a cationic active, and an anionic thickener. In another embodiment, the anionic pairing agent is pre-formed from the neutralization of an acid with a base. In another embodiment, the anionic pairing agent is formed in situ from the neutralization of an acid with a base. In one embodiment, the molar ratio of the base to the acid is at least about 0.70. In another embodiment, the equivalent ratio of the anionic pairing agent to the cationic active is at least about 0.70. The personal-care composition allows for previously unattainable levels of the cationic active to locate within the oil phase of the emulsion.Type: ApplicationFiled: March 23, 2010Publication date: December 2, 2010Inventors: Larry Rich Robinson, Gary Robert Kelm, Denver Michael Faulk
-
Publication number: 20100297207Abstract: The present invention relates to quaternary ammonium salts and their use as mold inhibitors. The quaternary salts can be prepared by a chloride ion-promoted reaction between a tertiary amine and an alcohol or polyol in strong acid solution. The quaternary ammonium salts can be applied to a substrate in order to impart anti-mold properties to the substrate. Preferably, the quaternary ammonium salt compounds are applied to paper substrates in an amount of about 1000 ppm. Preferably, the quaternary ammonium salts compounds are applied as mixtures of more than one quaternary ammonium salt compound. The treated substrate does not require encapsulators, binders, or retention aids.Type: ApplicationFiled: August 29, 2007Publication date: November 25, 2010Inventors: Maurice C. Kemp, David E. Lewis
-
Publication number: 20100298386Abstract: The present disclosure relates to compositions that are effective in controlling or in preventing mastitis in an animal. The disclosed compositions comprise a biocidal system, comprising a primary biocide and a preservative component; a nonionic surfactant having an HLB of from about 10 to about (20); an emollient system comprising an extradermal penetrating agent and an emollient base; a thickening agent; and an aqueous based carrier.Type: ApplicationFiled: October 2, 2008Publication date: November 25, 2010Inventor: Steven R. Burwell
-
Publication number: 20100240714Abstract: A dental composition for oral use, containing a phosphorylated saccharide (a), a cationic bactericidal agent (b) and a solvent (c). By using the dental composition for oral use of the present invention, the adhesion of the bacteria in the oral cavity to the surfaces of the teeth can be suppressed for a long period of time; therefore, the dental composition for oral use can be suitably used for, for example, a mouse-wash agent, a dentifrice agent, a gargling agent, a mouse spray, a coating agent or a bonding agent to tooth surface or a dental prosthetic, a hypersensitive inhibitor, a therapeutic agent for periodontal diseases, that is applied to a periodontal pocket, or the like.Type: ApplicationFiled: July 18, 2007Publication date: September 23, 2010Applicant: NAT. UNI. CORP. OKAYAMA UNIVERSITYInventors: Yasuhiro Yoshida, Naoko Namba, Noriyuki Nagaoka, Kaori Yoshimoto, Shogo Takashiba, Kazuomi Suzuki, Hiroshige Ishino, Takahiro Sekiguchi, Koichi Okada
-
Publication number: 20100216830Abstract: The present invention relates to a formulation comprising an endothermic cooling agent selected from the group consisting of xylitol, sorbitol, mannitol and erythritol having a heat of enthalpy between ?10 cal/g and ?100 cal/g, and one or more active agents wherein the endothermic agent is present in the formulation at an amount less than 10% w/w.Type: ApplicationFiled: October 17, 2008Publication date: August 26, 2010Applicant: Reckitt Benckkiser Healthcare (UK) LimtedInventors: Kingsley Iyoha, Neil Campbell Muir, Robert Rhoades, Alden Rodwell, David Michael Thurgood
-
Publication number: 20100190753Abstract: Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-+related disease.Type: ApplicationFiled: August 27, 2009Publication date: July 29, 2010Applicant: BELLUS Health (International) LimitedInventors: Xianqi KONG, Walter A. Szarek, Francine Gervais
-
Patent number: 7759386Abstract: This invention relates to novel pharmaceutical carrier or excipient systems and oral pharmaceutical compositions comprising 1-[4-(2-Azepan-1yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol or 2-(4-Hydroxy-phenyl)-3-methyl-1-(4-(2-piperidin-1-yl-ethoxy)benzyl]-1H-indol-5-ol, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 20, 2007Date of Patent: July 20, 2010Assignee: Wyeth LLCInventors: Eric Joel Benjamin, Wendy Ann Dulin, Jiwaji Gulabrao Suryawanshi
-
Publication number: 20100166886Abstract: The invention features a method of (i) reducing the appearance of pores or oil on the skin and (ii) evening skin tone or smoothing skin by applying to an area of skin in need of such treatment a composition including an anti-acne agent, an antimicrobial agent, and a lactate.Type: ApplicationFiled: March 12, 2010Publication date: July 1, 2010Inventors: Jeffrey M. Wu, Jue-Chen Liu, Jeannette Chantalat, Ying Sun, Stefanie A. Johnsen, Hanuman B. Jampani