Patent number: 7081448
Abstract: This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure wherein R1, R2, R3, R4, R5, R6, R7, and R8 are each, independently, acyl of 2–7 carbon atoms, haloacyl of 2–7 carbon atoms, nitroacyl of 2–7 carbon atoms, cyanoacyl of 2–7 carbon atoms, trifluoromethylacyl of 3–8 carbon atoms, benzoyl, or —SO3H; R9 is hydrogen, CN, NO2, halo, CF3, alkyl of 1–6 carbon atoms, or alkoxy of 1–6 carbon atoms; R10 is hydrogen, —NO2, —NHR11, —NHR13, —N(R13)2, —NCH3R13, —NHCO2alkyl, wherein the alkyl moiety contains 1–6 carbon atoms, alkylsulfonamide of 1 to 4 carbon atoms, Z is O or S; R11 is an ?-amino acid in which the ? carboxyl group forms an amide with the nitrogen of R10, wherein if said amino acid is glutamic acid or aspartic acid, the non-? carboxylic acid is an alkyl ester in which the alkyl moiety contains from 1–6 carbon atoms; R12 is hydrogen, CN, NO2, halo, CF3, alkyl of 1–6 carbon atoms, alkoxy of 1–6 carbon atoms, acyl of 2–7 carbon atoms, or benzoyl;
Type:
Grant
Filed:
October 24, 2003
Date of Patent:
July 25, 2006
Assignee:
Wyeth
Inventor:
Scott C Mayer