Tocopherols (e.g., Vitamin E, Etc.) Patents (Class 514/458)
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Patent number: 8859613Abstract: The invention provides compositions for preventing or treating kidney disease and improving kidney function comprising at least two ingredients selected from the group consisting of antioxidants and mitochondrial cofactors in amounts sufficient for preventing or treating kidney disease or for improving kidney function and methods for preventing and treating kidney disease or improving kidney function comprising administering such compositions to an animal susceptible to or suffering from kidney disease or impaired kidney function. In a preferred embodiment, the composition is admixed with one or more food ingredients to produce a food composition useful for preventing or treating kidney disease and improving kidney function, particularly in senior animals.Type: GrantFiled: June 20, 2013Date of Patent: October 14, 2014Assignee: Hill's Pet Nutrition, Inc.Inventors: Steven Curtis Zicker, Karen Joy Wedekind
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Publication number: 20140302169Abstract: A method wherein subjects having or at risk for having hyperopia, presbyopia or astigmatism are administered a composition having an effective amount of ocular antioxidants, including specifically macular pigments, to prevent, treat, or delay the onset of age-related macular degeneration (AMD).Type: ApplicationFiled: June 18, 2014Publication date: October 9, 2014Inventor: Richard Roberts
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Publication number: 20140301999Abstract: The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders.Type: ApplicationFiled: June 23, 2014Publication date: October 9, 2014Inventors: Jasbir Singh, Mark E. Gurney, Alex Burgin, Vincent Sandanayaka, Alexander Kiselyov, Adalie Motta, Gary Schiltz, Georgeta Hategan, Timothy Hagen
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Patent number: 8846653Abstract: Methods are disclosed for treating neoplastic disorders, such as pancreatic cancer, using tocotrienols; namely, gamma-tocotrienol and delta tocotrienol. The antitumorogenic effects of these compounds are shown both in vitro and in vivo using several human pancreatic cancer cell lines and MIA-PACA2 human pancreatic cancer cells xenografted in nude mice. Also disclosed are methods of testing the efficacy of potential chemotherapeutic agents by measuring their effect on surrogate endpoint biomarkers, such as Ki-67 and p27. Associated compounds are also disclosed.Type: GrantFiled: October 16, 2012Date of Patent: September 30, 2014Assignee: University of South FloridaInventors: Mokenge P. Malafa, Said M. Sebti
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Patent number: 8840883Abstract: Metallo-proteins including but not limited to lactoferrin (LF), transferrin (TF) and ovotransferrin (OTF) (all members of transferrin family), ceruloplasmin (CP) and metallo-thionein (MT) were found to stabilize and enhance the bio-functional activity of tocotrienol (T3), T3 mixtures or derivates. The synergism between MP and T3 also promote the intestinal transfer and the ultimate bio-availability of T3 and T3-derivatives for physiological functions. Such functional synergism includes hypocholesterolemic, anti-thrombotic, antioxidant, anti-athermogenic, anti-inflammatory and immuno-regulatory activities of T3 agents. Addition of a non-protein-type metal chelator provided further improvement in the action of the bio-functional activity of T3. These T3 compositions are useful as pharmaceuticals, in cosmetics, in foods and as nutritional supplements.Type: GrantFiled: November 9, 2012Date of Patent: September 23, 2014Assignee: Naidu LPInventors: A. Satyanarayan Naidu, A. G. Sreus Naidu, A. G. Tezus Naidu
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Patent number: 8841342Abstract: There is provided a method for improving the efficacy and/or transdermal transport of topically administered pharmaceuticals and pharmacologically active compounds, said method comprising the step of incorporating the pharmaceutical or pharmacologically active compound in a carrier comprising an effective amount of one or more complexes of a phosphate derivative of a lipophilic pharmaceutically acceptable compound.Type: GrantFiled: August 7, 2003Date of Patent: September 23, 2014Assignee: Vital Health Sciences Pty. Ltd.Inventors: Simon Michael West, David Kannar
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Publication number: 20140271844Abstract: Compositions, dietary supplement compositions, and topical compositions including activated fatty acids and methods for using activated fatty acids to treat a variety of diseases.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Inventor: Raymond A. Miller
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Publication number: 20140271593Abstract: Provided are compositions that contain water-soluble vitamin E derivative mixtures (compositions), such as tocopheryl polyethylene glycol succinate (TPGS), TPGS analogs, TPGS homologs and TPGS derivatives. The water-soluble vitamin E mixtures contain mixtures that include dimers and monomers of the vitamin E derivative, where the amount of dimer is greater than 12%, such as 29%, 35%, 50%, 60%, and the amount of monomer is less than 87% by weight of the water-soluble vitamin E derivative mixture. Also provided are products containing the water-soluble vitamin E derivative mixtures, including, concentrates for dilution into aqueous beverages and compositions for direct ingestion.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Inventor: Philip J. Bromley
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Publication number: 20140271596Abstract: The present invention relates to an emulsified hydrogel composition and to a production method therefor, wherein, by incorporating between 20 and 30 percent by weight of a gelling solution and an emulsion obtained by mixing between 45 and 60 percent by weight of an aqueous component and between 15 and 30 percent by weight of an oil component, it is possible to simultaneously provide the skin with an aqueous fraction and an oil fraction, and it is possible to enhance functionality due to the inclusion of a high content of a dermatologically active component dissolved in the oil component.Type: ApplicationFiled: September 12, 2012Publication date: September 18, 2014Applicant: GENIC CO., LTD.Inventors: Sung Jang Kim, Hyong-ii Park, Jae Han Cho, Eun Kyoung Choi, Jae hoon Kwak, Jae Min Lim, Hyun Jun Lim, Jai Hyun Kim, Min Seok Kim, Jin A. Yang, Hyun Oh Yoo, Jong Chul Kim
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Publication number: 20140256695Abstract: Systems and method are disclosed for forming a biocompatible cross-linked polymer having an interpenetrating polymer network (IPN) by cross-linking a heteropolysaccharide to form a single cross-linked material; and performing one or more additional cross-linkings on the single cross-linked material to form a multiple cross-linked material, wherein the multiple cross-linked material has one or more IPN regions resisting biodegradation in a human body than the single cross-linked material and one or more single cross-linked extensions radiating out from the IPN, wherein the combination of the IPN and the extension provide biodegradation resistance, soft touch feeling, and ease of insertion into the human body.Type: ApplicationFiled: November 11, 2012Publication date: September 11, 2014Inventors: Phi Nguyen, Loc Phan, Bao Tran, Thuan Nguyen
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Publication number: 20140255511Abstract: The present invention generally relates to the field of medical nutrition. For example, the present invention provides a composition that can be used to treat, prevent and/or reverse muscle atrophy related to immobilization and its consequences. One embodiment of the present invention concerns a composition comprising a leucine and antioxidants that can be used in accelerating muscle recovery after muscle atrophy.Type: ApplicationFiled: October 11, 2012Publication date: September 11, 2014Inventors: Dominique Dardevet, Isabelle Savary-Auzeloux, Didier Remond, Lydie Combaret, Gary Williamson, Magali Faure, Denis Breuille
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Publication number: 20140255370Abstract: A dietary supplement composition is presented, which includes omega-3 fatty acids, one or more of tocopherols and tocotrienols, and/or one or more essential oils. The dietary supplement may provide numerous health benefits to the user, including improvements in cardiovascular health, ocular health, cerebral and cognitive function, muscle function, and athletic performance. This supplement also has pronounced anti-inflammatory benefits. The collective effect of the composition may also maximize the positive effects of omega-3 fatty acids while also reducing or eliminating any negative effects associated with these fats.Type: ApplicationFiled: March 6, 2013Publication date: September 11, 2014Inventors: Marc Schreuder, D. GARY YOUNG
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Patent number: 8828960Abstract: The invention relates to pharmaceutical compositions that provide sustained-release of a pharmaceutically active compound and to methods of treating or preventing a condition in an animal by administering the pharmaceutical compositions to the animal. When the pharmaceutical compositions are administered to an animal by injection, they form a drug depot that releases the pharmaceutically active compound over time. The pharmaceutical compositions can also be administered orally.Type: GrantFiled: July 11, 2008Date of Patent: September 9, 2014Assignee: IDEXX Laboratories, Inc.Inventors: Yerramilli V.S.N. Murthy, Michael Atkinson
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Publication number: 20140242153Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.Type: ApplicationFiled: January 30, 2014Publication date: August 28, 2014Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu
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Publication number: 20140242055Abstract: Provided herein are compositions and methods for preparing foods and beverages that contain additives, such as nutraceuticals, pharmaceuticals, and supplements, such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochemicals, including phytosterols; other oils; and coenzymes, including Coenzyme Q10, and other oil-based additives.Type: ApplicationFiled: May 7, 2014Publication date: August 28, 2014Inventor: Philip J. Bromley
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Publication number: 20140242179Abstract: The present patent application relates to a novel coating system, coated compositions with such a coating system, as well as to the use of such compositions in the production food, feed, dietary supplements and/or pharmaceutical products, as well as to food, feed, dietary supplements and/or pharmaceutical products comprising such compositions.Type: ApplicationFiled: October 11, 2012Publication date: August 28, 2014Applicant: DSM IP ASSETS B.V.Inventors: Sylvain Diguet, Bruno H. Leuenberger, Fabien Laboulfie, Mehrdji Hemati
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Patent number: 8815955Abstract: A method wherein subjects having or at risk for having hyperopia, presbyopia or astigmatism are administered a composition having an effective amount of ocular antioxidants, including specifically macular pigments, to prevent, treat, or delay the onset of age-related macular degeneration (AMD).Type: GrantFiled: September 21, 2011Date of Patent: August 26, 2014Assignee: Kemin Industries, Inc.Inventor: Richard Roberts
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Patent number: 8816071Abstract: Compositions of matter including (R)-2,5,6,8-tetramethyl-8-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)-1,2,3,8,9,10-hexahydrochromeno[5,6-e][1,3]oxazine and (R)-2,6,8-trimethyl-8-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl)-1,2,3,8,9,10-hexahydrochromeno[5,6-e][1,3]oxazine are disclosed herein. Further disclosed are methods of preparation of such compounds and the use of such compounds as anticancer agents.Type: GrantFiled: November 30, 2012Date of Patent: August 26, 2014Assignee: First Tech International LimitedInventors: Khalid A. El Sayed, Paul W. Sylvester, Fathy A. Behery
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Patent number: 8815936Abstract: Described is a composition for preventing or treating an oxidative stress related disease or condition in a subject. The disease or condition is characterized by the presence of excess oxidative compounds in the subject, and the composition includes a synergistic combination of therapeutically effective amounts of resveratrol to promote NAD+ synthesis in the subject; a chelating agent to reduce production of additional oxidative compounds in the subject; and an antioxidant to minimize the oxidative activity in the subject.Type: GrantFiled: March 3, 2009Date of Patent: August 26, 2014Assignee: Nad Life Pty LtdInventors: Ross Stewart Grant, Nady Braidy, Gilles Guillemin, George Smythe
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Publication number: 20140228429Abstract: The present invention relates to a process for the production of extruded formulations comprising oil-in-water emulsion droplets, to such formulations as well as to the use.Type: ApplicationFiled: May 20, 2012Publication date: August 14, 2014Applicant: DSM IP ASSETS B.VInventors: Elger Funda, Alexandra Teleki, Leonardus Gerardus Bernardus Bremer, Pierre Elemans, Adriaan Willem Meesen
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Publication number: 20140221439Abstract: The present disclosure relates to lipid compounds of the general formula (I): R1—O—C(R2)(R3)—X??(I) wherein R1 is a C10-C22 alkyl group, a C10-C22 alkenyl group having 1-6 double bonds, or a C10-C22 alkynyl group having 1-6 triple bonds; R2 and R3 are the same or different and may be chosen from different substituents; and X is a carboxylic acid or a derivative thereof, such as a carboxylic ester, a carboxylic anhydride, a phospholipid, triglyceride, or a carboxamide; or a pharmaceutically acceptable salt, solvate, solvate of such salt, or a prodrug thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising at least one compound according to the present disclosure, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic, and inflammatory disease area.Type: ApplicationFiled: April 11, 2014Publication date: August 7, 2014Applicant: PRONOVA BIOPHARMA NORGE ASInventors: Ragnar Hovland, Anne Kristin HOLMEIDE, Tore SKJÆRET, Morten BRÆNDVANG
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Publication number: 20140212507Abstract: Disclosed is a method for determining a supplement regime for a subject diagnosed with age-related macular degeneration (AMD). The method involves determining the subject's risk of developing advanced AMD based on their genetic profile for the complement factor H gene and the ARMS2 gene and administering a supplement containing antioxidants and/or zinc based on their risk of developing advanced AMD.Type: ApplicationFiled: July 31, 2013Publication date: July 31, 2014Applicant: ArcticDx Inc.Inventors: Brent Zanke, Carl Awh
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Publication number: 20140213558Abstract: Embodiments of the invention relate generally to the treatment of inflammatory diseases and disorders and, more particularly, to the treatment of symptoms of inflammatory diseases and disorders using thymoquinone (TQ) alone or in combination with other compounds, including eicosapentaenoic acid (EPA). In one embodiment, the invention provides a pharmaceutical composition suitable for the treatment of at least one symptom of an inflammatory disease or disorder, comprising: an effective amount of thymoquinone; and at least one physiologically-acceptable carrier, wherein an effective amount of thymoquinone is an amount capable of reducing or preventing the at least one symptom of the inflammatory disease or disorder.Type: ApplicationFiled: August 17, 2012Publication date: July 31, 2014Applicant: CREDE OILS (PTY) LTDInventor: Philipp Crede
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Patent number: 8784899Abstract: The present invention relates to compositions comprising a vitamin E analog and an arsenic compound for treating hyperproliferative cells disorders such as cancer. The composition of the invention potentiates arsenic toxicity towards cancer cells and can also prevent arsenic-mediated toxicity of non-cancerous cells.Type: GrantFiled: October 4, 2006Date of Patent: July 22, 2014Assignee: Samuel Waxman Cancer Research FoundationInventors: Wilson H. Miller, Zuanel Diaz Heredia, Hyman M. Schipper, Koren K. Mann
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Patent number: 8784867Abstract: The instant invention pertains to a method for producing contact lenses with improved oxidative stability of Carotenoids in the contact lens. The method of the invention involves adding a vitamin E material into a contact lens in an amount sufficient to reduce oxidative degradation of Carotenoids in the lens by at least about 30% in comparison with an identical contact lens without the vitamin E material.Type: GrantFiled: December 17, 2012Date of Patent: July 22, 2014Assignee: Novartis AGInventors: Newton T. Samuel, Nirupama Kenkare, Peter D. Lackey, Jessie Chen
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Patent number: 8785443Abstract: Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel disease, and arthritis are disclosed.Type: GrantFiled: October 14, 2011Date of Patent: July 22, 2014Assignee: XenoPort, Inc.Inventors: Archana Gangakhedkar, Xuedong Dai, Noa Zerangue, Peter A. Virsik
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Publication number: 20140199367Abstract: The present invention relates to liquid application for skin rejuvenation created from specific amino acids, lipids, nucleic acids and vitamins. This collection of molecules delivers precisely the factors necessary to a specific site requiring healing; a direct intervention system to most expeditiously remodel skin with building blocks. This delivery is a transdermal topical delivery and healing is via specific molecules that engender a false autocoid reaction rapidly followed by an incremental healing-anti-inflammatory response augmented by very specific GRAS ingredients in the invention and also recruited from the body to this needy site. Energy is brought to site by transdermally delivered protons and enhanced by the local vascular flow initiated by transdermal molecules. This delivery system bypasses digestion and dilution. Key is a lipophilic carrier with nuclear and mitochondrial ligands that rapidly penetrate and permeate all membranes and truncates the inflammatory site quickly manifesting curation.Type: ApplicationFiled: January 17, 2013Publication date: July 17, 2014Inventor: Donald P. Orofino
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Publication number: 20140200268Abstract: The present invention provides for compositions, medicaments, and methods for treating or alleviating the symptoms of dry eye syndrome or chronic dry eye. More specifically, the present embodiments provide for medicaments consisting of tocopherol or tocotrienol eyedrops. A single topical administration of tocopherol or tocotrienol eyedrops in the eyes of a subject suffering from dry eye alleviates symptoms for at least one day. In particular, the eyedrop medicament consists of ?-tocopheryl acetate; ?-tocopheryl acetate and about 0.5% aqueous component; or ?-tocopheryl acetate, about 2.5% tocopherol emulsifier, and about 20% to about 30% aqueous excipient.Type: ApplicationFiled: March 18, 2014Publication date: July 17, 2014Applicant: RAMSCOR, INC.Inventors: Vernon G. Wong, Louis L. Wood
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Patent number: 8778989Abstract: The present invention relates to a cosmetic composition comprising: a—from 85.0% to 99.9% by weight of a lipid fraction of vegetable origin, and b—from 0.1% to 15.0% by weight of an anti-crystallizing agent, the percentages being defined on the basis of the total weight of the composition. The present invention also relates to a cosmetic composition comprising olein, propoxylated stearyl alcohol and/or propoxilated stearyl ether. These cosmetic compositions are ecologically correct and exhibit high resistance to oxidation and to solidification, and further provide to the skin softness, lubrication and also brings about the formation of a film that protects the skin against drying out.Type: GrantFiled: July 1, 2005Date of Patent: July 15, 2014Assignee: Natura Cosmeticos S.A.Inventors: Roberta Roesler, Rosa Friedlander
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Publication number: 20140193532Abstract: This invention relates to novel compositions and methods of use by which the compositions of this invention are applied topically to one or more body parts of at least two individuals who bring said body parts into contact with the other individual and, when said body parts come into contact with each other, permit the formulations to interact and thereby achieve an unexpected sensation to each individual.Type: ApplicationFiled: March 10, 2014Publication date: July 10, 2014Applicant: McNeil-PPC, Inc.Inventors: Nawaz Ahmad, Cheng-Ji Cui, Bryant Ison
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Publication number: 20140186279Abstract: The present invention relates to topical bioadhesive formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.Type: ApplicationFiled: December 23, 2013Publication date: July 3, 2014Applicant: CAMURUS ABInventors: Fredrik JOABSSON, Margareta LINDEN, Krister THURESSON, Fredrik TIBERG
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Publication number: 20140179776Abstract: The present invention relates to a cosmetic composition, particularly indicated for cleaning the skin, which comprises a plant oil portion comprising: at least 70% of fatty chain with 18 carbon atoms, C18, such chain may be either saturated or unsaturated; up to 20% of fatty chain with 16 carbon atoms, C16, such chain may be either saturated or unsaturated; at least one saponifying agent; and an aqueous portion. Further, the invention relates to a process for preparing the cosmetic composition and the use of this composition. Such a cosmetic composition has acceptance and pleasantness that are superior to those of the prior-art products, as well as extremely superior formation of film.Type: ApplicationFiled: March 30, 2012Publication date: June 26, 2014Applicant: NATURA COSMETICOS S.A.Inventors: Andre Luis Brasilino De Carvalho, Rodrigo Pereira Lima, Reinaldo Rubens Miguel, Tadeu De Oliveira Marin Chicol
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Patent number: 8759547Abstract: A process for the extraction of Vitamin E from annatto plant matter is disclosed wherein annatto seed matter is subjected, before extraction, to acidification using amla fruit matter. After the acidification, the mixture of the two plant matters is extracted by water. The acidification converts the vitamin E compounds in the plant matter into more water-soluble forms, thus enhancing the vitamin yield. More of the vitamin is obtained in the ester form than in the form of vitamin alcohols. Processing time is reduced.Type: GrantFiled: July 30, 2012Date of Patent: June 24, 2014Inventors: Ramaswamy Rajendran, Kamala Rajendran
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Publication number: 20140171500Abstract: The present invention relates a new drink formula comprising fresh marine omega-3 oil in an emulsion and antioxidants well known to be health promoting to humans, and process for the production of said drink and the use of said drink for production of a medicament.Type: ApplicationFiled: February 19, 2014Publication date: June 19, 2014Applicant: PHARMALOGICA ASInventors: Janne Sande MATHISEN, Henrik MATHISEN
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Patent number: 8747817Abstract: A new skin care system includes day and night skin cream compositions comprising nutrients and antioxidants for use by children between six months and eighteen years of age. The day skin cream composition provides protection from UV radiation and the night skin cream composition contains no sun protection ingredients and elevated levels of nutrients and antioxidants. A child-friendly bottle for each composition can be used by young children without difficulty. A fragrance included in each composition is popular with children, and the bottle for the day composition has graphics indicating day-time use and the bottle for the night composition has graphics indicating night-time use. The day composition is applied topically each day to the face after tooth-brushing, and the night composition is applied topically to the face each night after tooth-brushing.Type: GrantFiled: December 2, 2011Date of Patent: June 10, 2014Inventor: William Scott Prendergast
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Publication number: 20140155359Abstract: A clear and nutritive microemulsion comprising an aqueous phase in which at least one liposoluble active ingredient is dispersed, a first surfactant included in the group consisting of non-ionic surfactants with a high HLB and non-ionic surfactants with medium HLBs; and a second surfactant, characterized in that said second surfactant is chosen from the group consisting of anionic surfactants which have an HLB ?25.Type: ApplicationFiled: July 13, 2012Publication date: June 5, 2014Applicant: PRAYONInventors: Guy Broze, Claire Pucci, Adeline Navarro
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Publication number: 20140147514Abstract: A process for extracting vitamins and minerals from a first plant matter(s) is disclosed wherein the said first plant matter(s) is treated with acidic matter followed by extraction with water. Said treatment converts the water-insoluble vitamins and minerals into water-soluble forms leading to a more comprehensive extraction with better yields of the plant constituents. Suitable selection of the first and second plant matter(s) and their proportions yields an extract that is a ready-made formulation of the desired vitamins and minerals in RDA quantities. Other advantages are reduced processing times and processing steps. Extraction of guava fruits, guava leaves, holy basil leaves, lemon peels, amla fruits, annato seeds, Wrightia tinctoria, Lantana camara, bamboo shoots, mustard seeds, and curry leaves is described.Type: ApplicationFiled: July 30, 2012Publication date: May 29, 2014Inventors: Ramaswamy Rajendran, Kamala Rajendran
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Publication number: 20140148506Abstract: Provided are compositions of various silicone compounds loaded with active pharmaceutical agents, which are suitable for promoting the healing of skin wounds and the reduction or prevention of scarring.Type: ApplicationFiled: November 14, 2013Publication date: May 29, 2014Applicant: Allergan, Inc.Inventors: Jordan Thompson, Alexei Goraltchouk
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Publication number: 20140148439Abstract: The invention relates to the use of antioxidants such as, ascorbic acid (Vitamin C), Tocopherol (Vitamin E), vitamin A and polyphenols, for the treatment of cognitive and behavioural disorders in patients with Fragile X syndrome. Specifically, the invention relates to the use of said antioxidants in a pre-determined concentration in a therapeutic doses, in order to obtain the greatest amount of antioxidants possible in all the tissues of the organism, so as to eliminate the excess free radicals produced in the cells and to treat the aforementioned cognitive and behavioural disorders in patients with Fragile X syndrome.Type: ApplicationFiled: December 16, 2011Publication date: May 29, 2014Applicants: SERVICIO ANDALUZ DE SALUD, INSTITUTO MEDITERRANEO PARA EL AVANCE DE LA BIOTECNOLOGIA Y LA INVESTIGACIONInventors: María Yolanda De Diego Otero, Lucia María Pérez Costillas, Ignacio Del Arco Herrera
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Patent number: 8728535Abstract: In one embodiment of the present invention, a pharmaceutically-acceptable single-dosage formulation consists essentially of about 500 mg of vitamin C; about 400 IUs of vitamin D3; about 125 IUs of vitamin E; about 25 mg of vitamin B1; about 3.4 mg of vitamin B2; about 35 mg of niacin; about 35 mg of vitamin B6; about 1.25 mg of folic acid; about 70 mcg of vitamin B12; about 5 mg of pantothenic acid; about 75 mcg of biotin; about 35 mg of magnesium; about 35 mg of zinc; about 1 mg of copper; about 125 mcg of selenium; about 150 mcg of chromium; about 10 mg of alpha lipoic acid; about 35 mg of co-enzyme Q-10; about 400 mcg of lutein; about 125 mcg of lycopene; and at least one or more excipients.Type: GrantFiled: June 19, 2012Date of Patent: May 20, 2014Assignee: Vertical Pharmaceuticals, LLCInventors: Steven A. Squashic, Kevin M. Hudy, David C. Purdy
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Patent number: 8722728Abstract: The present invention provides for compositions, medicaments, and methods for treating or alleviating the symptoms of dry eye syndrome or chronic dry eye. More specifically, the present embodiments provide for medicaments consisting of tocopherol or tocotrienol eyedrops. A single topical administration of tocopherol or tocotrienol eyedrops in the eyes of a subject suffering from dry eye alleviates symptoms for at least one day. In particular, the eyedrop medicament consists of ?-tocopheryl acetate; ?-tocopheryl acetate and about 0.5% aqueous component; or ?-tocopheryl acetate, about 2.5% tocopherol emulsifier, and about 20% to about 30% aqueous excipient.Type: GrantFiled: October 9, 2009Date of Patent: May 13, 2014Assignee: Ramscor, Inc.Inventors: Vernon G. Wong, Louis L. Wood
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Publication number: 20140127171Abstract: Methods of treating chronic post-traumatic encephalopathy (PTE) using regenerative approaches is described. In one embodiment, molecules with capability of stimulating endogenous neural stem cells is provided. In another embodiment, cell therapeutics are provided capable of addressing angiogenic deficits in patients suffering from PTE. In another embodiment, cells are utilized to induce activation of endogenous progenitor cells in the central nervous system of PTE patients. Furthermore, low level laser irradiation is disclosed as a means of treatment of PTE either through direct administration to CNS tissue for stimulation of endogenous progenitor cells and reparative processes, or together with administration of exogenous stem cells, whether autologous or allogeneic. In a further embodiment exogenous stem cells are pretreated with laser prior to administration.Type: ApplicationFiled: November 4, 2013Publication date: May 8, 2014Inventors: Roger Nocera, James Eaker
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Patent number: 8716330Abstract: The present invention relates to a dietary supplement composition made of: linolenic expeller pressed soybean oil in the range of 65%-85%, Omega 3 (18/12) fish oil 15%-35%, and 1%-20% alpha-tocopherol and a method to use this composition to supplement the diet of a domestic animal, such as a canine or an equine.Type: GrantFiled: August 16, 2013Date of Patent: May 6, 2014Inventor: Murray Fulgham
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Patent number: 8715632Abstract: Compositions for treating hair are disclosed. Methods of making and using compositions for treating hair are also disclosed.Type: GrantFiled: November 26, 2012Date of Patent: May 6, 2014Inventor: S. Katharine Presty
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Patent number: 8716260Abstract: The present invention provides antioxidant compositions comprising S-adenosylmethionine (SAMe), vitamin E and vitamin C and uses thereof for the treatment of liver injury and insulin resistance.Type: GrantFiled: May 27, 2011Date of Patent: May 6, 2014Assignee: University of ManitobaInventors: Wilfred Wayne Lautt, Zhi Ming
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Patent number: 8716332Abstract: The present invention relates to a dietary supplement composition made of: linolenic expeller pressed soybean oil in the range of 65%-85%, Omega 3 (18/12) fish oil 15%-35%, and 1%-20% alpha-tocopherol and a method to use this composition to supplement the diet of a domestic animal, such as a canine or an equine.Type: GrantFiled: August 16, 2013Date of Patent: May 6, 2014Inventor: Murray Fulgham
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Patent number: 8716331Abstract: The present invention relates to a dietary supplement composition made of: linolenic expeller pressed soybean oil in the range of 65%-85%, Omega 3 (18/12) fish oil 15%-35%, and 1%-20% alpha-tocopherol and a method to use this composition to supplement the diet of a domestic animal, such as a canine or an equine.Type: GrantFiled: August 16, 2013Date of Patent: May 6, 2014Inventor: Murray Fulgham
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Patent number: 8709526Abstract: A novel method for improving the meat quality of an animal is provided. In one embodiment, the method comprises feeding the animal a diet supplemented with oleic acid and tocols and subsequently formulating the meat with a non-tocol antioxidant such as rosemary extract. The source of the oleic acid and/or tocols may be transgenic corn that employs the FAD-2 gene as a silencing agent for a high-oleic phenotype and/or expresses the HGGT gene for a high-tocotrienol phenotype. The method improves the quality of meat from both non-ruminants and ruminants.Type: GrantFiled: September 8, 2006Date of Patent: April 29, 2014Assignee: E.I. duPont de Nemours and CompanyInventors: Fred R. Wolf, Cindi S. Zimmermann, Court A. Saunders
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Patent number: 8703195Abstract: Disclosed is a method in which poloxamer, a resin, and/or a tocopherol is/are fused, and the material that is to be treated is intimately dispersed with said melt. After being introduced into the melt, the material that is to be treated is coated with water to prevent hardening, and the spontaneously forming gel is homogenized. The obtained product is composed of a transparent gel that is based on at least one poloxamer, a resin or a tocopherol, and an active substance which is solubilized, dispersed, and stabilized therein and whose consistency ranges from solid, semisolid, i.e. aspic-like, to liquid. The micelles of said solubilized matter remain stable even when the same is diluted well below the CMC of poloxamer.Type: GrantFiled: March 9, 2007Date of Patent: April 22, 2014Assignee: Biorem AGInventor: Hanspeter Strobel
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Publication number: 20140105822Abstract: This invention relates to a nanosphere comprising tocopherol, an amphiphilic spacer and a therapeutic agent, an imaging agent, a hydrophobic antioxidant, a hydrophobic nonsteroidal anti-inflammatory drug (NSAID) derivative, a hydrophobic antioxidant and anti-inflammatory derivative of a nonsteroidal anti-inflammatory drug (NSAID), a statin lactone derivative, an antioxidant derivative of camptothecin or camptothecin analog, or a combination thereof. Methods of synthesizing the nanospheres and their use in treating, detecting or diagnosing diseases are also provided.Type: ApplicationFiled: December 17, 2013Publication date: April 17, 2014Applicant: CEDARS-SINAI MEDICAL CENTERInventors: John S. Yu, Bong Seop Lee