Abstract: The present invention is directed to polymeric-prodrug transport forms of the formula: wherein: E1-4 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls, substituted C1-6 heteroalkyls, C1-6 alkoxy, phenoxy, C1-6 heteroalkoxy, and at least one of E1-4 includes a B moiety, wherein B is a leaving group, OH, a residue of a hydroxyl-or amino-containing moiety or wherein J1 is the same as J, or another member of the group defining J and E5 is the same as E1-4, or another member of the group defining E1-4; Y1-2 are independently O, S or NR9; M is a heteroatom selected from either X or Q; wherein X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(=Y2); R2-5 and R7-9 are independently selected

Abstract: A pharmaceutical and/or veterinary formulation for sustained release of a peptide agonist or analogue, comprising about 2-15% (w/w) of at least one peptide agonist or analogue other than deslorelin (on an active basis), about 0.5-3.5% (w/w) lecithin and the balance stearin. The formulation preferably comprises a GnRH agonist or analogue and is used for the treatment of various conditions where suppression of sex hormone levels is beneficial, particularly prostate cancer, ovarian and breast cancer, and benign prostatic hyperplasia in dogs.

Abstract: Biocidal preservatives for use especially in preventing rotting and deterioration of wood include quaternary ammonium compounds which preferably have a fatty aliphatic substituent on the quaternary nitrogen atom. Especially preferred are cocoalkyl substituents. Other substituents can include alkoxy groups, arenes, and heterocyclic groups with or without ring substitutions, for example. The quaternary ammonium compound can also contain an amine nitrogen and can be complexed with copper.

Abstract: The present invention is directed to polymeric- prodrug transport forms of the formula: ##STR1## wherein: B is a leaving group, OH, a residue of a hydroxyl-containing moiety or ##STR2## wherein B.sub.1 is a leaving group, OH or a residue of a hydroxyl-containing moiety;Y.sub.1-2 are independently O or S;M is selected from either X or Q; wherein X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(.dbd.Y.sub.2); R.sub.2-5 are independently selected from the group consisting of hydrogen, C.sub.1-6 alkyls, C.sub.3-12 branched alkyls, C.sub.3-8 cycloalkyls, C.sub.1-6 substituted alkyls, C.sub.3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C.sub.1-6 heteroalkyls and substituted C.sub.1-6 heteroalkyls;(m) is zero or one;(n) is a positive integer;(p) is zero or a positive integer;Z is an electron withdrawing group; andR.sub.

Abstract: The presence of isobornyl thiocyanoethyl ether exerts a synergistic effect on the insecticidal activity against harmful wood eating insects of certain known insecticides selected from the group consisting of imidacloprid, phenyl pyrazole insecticides, pyrethroid insecticides and non-ester pyrethroid insecticides.

Abstract: Vegetable sources of cancer chemoprotective agents have been identified which are extraordinarily rich in glucosinolates, metabolic precursors of isothiocyanates. The vegetable sources are used to provide a dietary means of reducing the level of carcinogens in mammals.

Abstract: The presence of isobornyl thiocyanoethyl ether exerts a synergistic effect on the insecticidal activity against harmful wood eating insects of certain known insecticides selected from the group consisting of imidacloprid, phenyl pyrazole insecticides, pyrethroid insecticides and non-ester pyrethroid insecticides.

Abstract: Compositions comprising a mixture of 2-(thiocyanomethylthio)benzothiazole and methylene-bis(thiocyanate) with dimethylamide of a carboxylic acid are disclosed which are synergistically effective compared to the respective components alone in controlling the growth of microorganisms in or on a product, material, or medium. Methods to control the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.

Abstract: Methods of inhibiting IL-6 in a cell by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable derivatives thereof.

Abstract: Compositions and methods of treating anemia, cancer, AIDS, or severe .beta.-chain hemoglobinopathies by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable derivatives thereof or derivatives thereof alone or in combination or in conjunction with other therapeutic agents including retinoids, hydroxyurea, and flavonoids. Intravesicle methods of treatment of cancers phenylacetate. Pharmacologically-acceptable salts alone or in combinations and methods of preventing AIDS and malignant conditions, and inducing cell differentiation are also aspects of this invention. A product as a combined preparation of phenylacetate and a retinoid, hydroxyurea, or flavonid (or other mevalonate pathway inhibitor) for simultaneous, separate, or sequential use in treating a neoplastic condition in a subject. Methods of modulating lipid metabolism and/or reducing serum triglycerides in a subject using phenylacetate.

Abstract: The present invention comprises methods and compositions for reducing or eliminating multidrug resistance in cancers or certain infections by drug resistant microorganisms in patients. According to the method and composition of the present invention, a non-ionic amphipathic diester of fatty acids or a reverse poloxmer is administered to a patient in which a cancer or microorganism exhibits multidrug resistance to the chemotherapeutic agent. The method and composition of the present invention may be employed with particular efficacy where multidrug resistance to any chemotherapeutic agent has been conferred upon a cancer.

Abstract: A method of protecting a tree including removing parts of the tree which are one of susceptible to necrosis from pathogenic microbes or affected by necrosis and leaving exposed tree surfaces; and applying to the exposed tree surfaces a composition which is an ointment and which is effective to protect a tree against disease which includes allyl isothiocyanate; vinyl acetate resin as a spreading agent; water-based colored paint; metallic powder which is finely divided and which is one of iron or ferrous oxide; and pH regulating agent. The allyl isothiocyanate may be encapsulated by a coating material.

Abstract: Compositions for controlling the growth of microorganisms in or on a product, material or medium comprising synergistically effective amounts of methylene-bis(thiocyanate) and at least one organic acid, its salt or ester are disclosed. Methods to control the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.

Abstract: An antimicrobial composition comprising AIT and a polyhydric alcohol which may have aldehyde group or ketone group; an antimicrobial composition comprising a surfactant and said composition; a method for treating microorganisms; and a method for retaining freshness of vegetables, etc., both of which methods comprising treating the target substances such as perishables with the composition of the present invention or an aqueous solution containing said composition.

Abstract: The present invention comprises methods and compositions for reducing or eliminating multidrug resistance in cancers or certain infections by drug resistant microorganisms in patients. According to the method and composition of the present invention, a non-ionic amphipathic diester of fatty acids or a reverse poloxmer is administered to a patient in which a cancer or microorganism exhibits multidrug resistance to the chemotherapeutic agent. The method and composition of the present invention may be employed with particular efficacy where multidrug resistance to any chemotherapeutic agent has been conferred upon a cancer.

Abstract: It comprises: 0.005-1.0% of trimethoprim or a pharmaceutically acceptable salt thereof: 0.01-0.3% of polymyxin or a pharmaceutically acceptable salt thereof: 0.001-5% of a steroidal or non-steroidal anti-inflammatory drug and, optionally, one or more ingredients selected from among isotonizing agents, pH buffers, viscosity modifying agents, wetting agents, chelating agents, anti-oxidants, preservatives and vehicles. The formulation has a pH between 4 and 8.5.It is applicable in the treatment of ophthalmic and otic infections accompanied by inflammation.

Abstract: A method for controlling phytopathogenic fungi comprises applying a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of manganese-zinc ethylenebis(dithiocarbamate), manganese ethylenebis(dithiocarbamate), zinc ammoniate ethylenebis(dithiocarbamate), zinc ethylenebis(dithiocarbamate), 2-cyano-N-((ethylamino)carbonyl)-2-(methoxyimino)acetamide, and (E,Z) 4-(3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acryloyl)morpholine to plant seed, to plant foliage or to a plant growth medium and provides higher fungicidal activity than separate use of the same compounds.

Abstract: Compositions for controlling the growth of microorganisms in or on a product, material or medium comprising synergistically effective amounts of methylene-bis(thiocyanate) and at least one organic acid, its salt or ester are disclosed. Methods to control the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.

Abstract: Compositions and methods of treating anemia, cancer, AIDS, or severe .beta.-chain hemoglobinopathies by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable derivatives thereof or derivatives thereof alone or in combination or in conjunction with other therapeutic agents including retinoids, hydroxyurea, and flavonoids. Intravesicle methods of treatment of cancers phenylacetate. Pharmacologically-acceptable salts alone or in combinations and methods of preventing AIDS and malignant conditions, and inducing cell differentiation are also aspects of this invention. A product as a combined preparation of phenylacetate and a retinoid, hydroxyurea, or flavonid (or other mevalonate pathway inhibitor) for simultaneous, separate, or sequential use in treating a neoplastic condition in a subject. Methods of modulating lipid metabolism and/or reducing serum triglycerides in a subject using phenylacetate.

Abstract: The present invention comprises methods and compositions for reducing or eliminating multidrug resistance in cancers or certain infections by drug resistant microorganisms in patients. According to the method and composition of the present invention, a non-ionic amphipathic diester of fatty acids or a reverse poloxmer is administered to a patient in which a cancer or microorganism exhibits multidrug resistance to the chemotherapeutic agent. The method and composition of the present invention may be employed with particular efficacy where multidrug resistance to any chemotherapeutic agent has been conferred upon a cancer.

Abstract: Compositions for controlling the growth of microorganisms in or on a product, material or medium comprising synergistically effective amounts of methylene-bis(thiocyanate) and at least one organic acid, its salt or ester are disclosed. Methods to control the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.

Abstract: Synergistic antimicrobial combinations of polyether polyamino methylene phosphonates and one or more members selected from the group consisting essentially of the following non-oxidizing biocides:didecyl dimethyl ammonium chloride;dodecylguanidine hydrochloride;methylene bisthiocyanate;2,2-dibromo-3-nitrilo-propionamide;2-(thiocyanomethylthio)benzothiazole glutaraldehyde;potassium dimethyldithiocarbamate;5-chloro-2-methyl-4-isothiazolin-3-one;2-methyl-4-isothiazolin-3-one;tetrahydro-3,5-dimethyl-2,H-1,3,5-thiadiazin-2-thione;1,2-dibromo-2,4-dicyanobutane;are useful for inhibiting microbial growth in a variety of aqueous systems.

Abstract: Compositions for controlling the growth of microorganisms in on a product, material or medium comprising synergistically effective amounts of methylene-bis(thiocyanate) and at least one organic acid, its salt or ester are disclosed. Methods to control growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.

Abstract: An industrial microbicide which comprises at least one haloglyoxime derivative of the formula (I): ##STR1## wherein X is a halogen atom; Y is a hydrogen atom, a halogen atom or a lower alkyl group having 1 to 4 carbon atoms; and Z is a hydrogen atom or an optionally halogenated lower alkanoyl group having 1 to 5 carbon atoms; and a known industrial microbicidal ingredient selected from the group consisting of an organonitrogen-sulfur compound, an organohalogen compound, an organonitrogen compound and an organosulfur compound; and optionally a carrier or diluent.

Abstract: This invention relates to methods and compositions for obtaining synergistic anti-microbial (biocidal) activity using a combination of methylene(bisthiocyanate) and 2-bromo-2-nitropropane-1,3-diol. The methods and compositions of the invention are very effective in preventing microbial spoilage of latex carpet backing compounds and in paper and pulp preparation, particularly with respect to latex paper coatings. Compositions containing the active ingredients in ratios of from 0.001 parts methylene(bisthiocyanate) to 1 part 2-bromo-2-nitro-propane-1,3-diol to 10 parts methylene(bisthiocyanate) to 1 part 2-bromo-2-nitro-propane-1,3-diol.

Abstract: Alpha-Arylacrylic acid derivatives of the general formula I ##STR1## where X is ethylene or ethenylene; n is 0 or 1;m is 0, 1, 2, 3 or 4;R.sup.1 is cyano, cyanato, thiocyanato, nitro, hydroxyl, carboxyl, haloalkyl, haloalkoxy, unsubstituted or substituted cycloalkyl, cycloalkenyl, cycloalkadienyl, alkenyl, alkynyl or amino, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, unsubstituted or substituted benzyloxycarbonyl, benzoyl, phenylalkyl, phenylalkoxy or phenoxyalkyl,or R.sup.1 together with one of the radicals R.sup.2 forms an unsubstituted or substituted 1,3-butadiene-1,4-diyl group or an unsubstituted or substituted chain consisting of carbon members and an oxygen member, andR.sup.2 is halogen, unsubstituted or substituted alkyl, alkoxy, alkenyloxy, alkynyloxy, alkadienyloxy, benzyloxy or benzylthio, are used for controlling pests.

Abstract: Synergistic microbicidal compositions are disclosed, comprising 4,5-dichloro-2-cyclohexyl-3-isothiazolone and one or more known microbicides for more effective, and broader control of microorganisms in various systems.

Abstract: A foam carrier for a dust control agent and a pesticidal material is provided to control fugitive dust dissemination and biological activity in bulk/granular solids.

Abstract: A method for stabilizing metal ions in recirculating water systems is disclosed. This method utilizes an admixture comprising a) an ethylenically unsaturated water-soluble polymer and/or a water soluble phosphonate, b) methylene bis(thiocyanate), and c) 2-(thiocyanomethylthio)benzothiazole to solubilize metal ions thereby reducing deposition and corrosion.

Abstract: An insecticidal and/or acaricidal composition comprising as active ingredients 2-methyl-4-oxo-3-(2-propynyl)cyclopent-2-enyl chrysanthemate and a phenoxybenzyl ester compound having the formula [I], ##STR1## wherein R.sup.1 is hydrogen or cyano, R.sup.2 is hydrogen or fluorine, and X is chlorine or bromine, is markedly effective against insect pests having a low sensitivity to pyrethroid and acarine pests which cannot be effectively controlled by the use of a single agent.

Abstract: An agricultural granule capable of carrying and releasing incorporated biocidal or nutritional agricultural chemicals. The granule is formed by the agitative agglomeration of a plant fiber slurry and resembles a clay granule in all respects except for its chemical inertness.

Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of 2-(decylthio)ethanamine hydrochloride and methylene bis(thiocyanate). The method comprises administering between about 0.1 to about 200 parts of this combined treatement (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.

Abstract: Method of providing anti-sickling of red blood cells in sickle cell anemia patients without hemolyzing said cells, using thiocyanates alone, or together with Vitamin B.sub.6.

Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, faculative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of methylene bis(thiocyanate) and a tetraalkyl phosphonium halide compound. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.

Abstract: In the control of nematodes, use is made of a formulation using D-limonene as a solvent to carry an effective dosage of chloropicrin. The formulation can also include an amount of methyl isothiocyanate corresponding in volume approximately to the amount of chloropicrin. The combination of these two components is synergistic. With the further addition of diazinon, a double synergistic effect is obtained.

Abstract: A synergistic biocide blend of 2-(p-hydroxyphenol) glyoxylohydroximoyl chloride and methylene bis thiocyanate.

Abstract: A superior industrial biocide for treating industrial process waters is afforded in the combination of 1,5-pentanedial and methylene bis thiocyanate.

Abstract: The instant invention is directed to synergistic antimicrobial admixtures comprising 2-bromo-2-bromomethylglutaronitrile and methylene bis(thiocyanate) and its use in inhibiting microbial growth.

Abstract: Sulforaphane has been isolated and identified as a major and very potent phase II enzyme inducer in broccoli (Brassica oleracea italica). Sulforaphane is a monofunctional inducer, inducing phase II enzymes selectively without the induction of aryl hydrocarbon receptor-dependent cytochromes P-450 (phase I enzymes). Analogues differing in the oxidation state of sulfur and the number of methylene groups were synthesized, and their inducer potencies were measured. Sulforaphane is the most potent of these analogues. Other analogues having different substituent groups in place of the methylsulfinyl group of sulforaphane were also synthesized and assessed. Of these, the most potent are 6-isothiocyanato-2-hexanone and exo-2-acetyl-6-isothiocyanatonorbornane.