Polysaccharide Patents (Class 514/54)
Chitin or derivative (Class 514/55)
Heparin or derivative (Class 514/56)
Cellulose or derivative (Class 514/57)
Dextrin or derivative (Class 514/58)
Dextran or derivative (Class 514/59)
Starch or derivative (Class 514/60)
Tri- or tetrasaccharide (Class 514/61)
  • SACCHARIDE FRACTION FROM WHEAT, ISOLATION PROCESS AND FIELD OF USE OF THE INVENTION
    Publication number: 20150148309
    Abstract: Fractions extracted from wheat seeds germinated and macerated in water having a molecular weight comprised between 3 and 30 K Daltons are described.
    Type: Application
    Filed: June 4, 2013
    Publication date: May 28, 2015
    Inventor: Rodolfo Riccio
  • DEUTERIUM-ENRICHED HYALURONAN
    Publication number: 20150148310
    Abstract: The present invention generally relates to deuterium-enriched hyaluronan, d-HA, compositions containing the same, methods of using the same, and methods for making the same.
    Type: Application
    Filed: November 25, 2014
    Publication date: May 28, 2015
    Inventor: Glenn Prestwich
  • COMPOSITIONS COMPRISING SULFORAPHANE OR A SULFORAPHANE PRECURSOR AND A MUSHROOM EXTRACT OR POWDER
    Publication number: 20150147352
    Abstract: The invention relates to the combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, an enzyme potentiator, and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The invention also relates to the combination of sulforaphane or a derivative thereof and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The present invention also relates to the combination of a broccoli extract or powder and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The present provides compositions and methods relating to these combinations.
    Type: Application
    Filed: July 3, 2013
    Publication date: May 28, 2015
    Inventors: Brian Cornblatt, Grace Cornblatt, Anton Bzhelyansky, Robert Henderson
  • GALACTO-RHAMNOGALACTURONATE COMPOSITIONS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH ELEVATED INDUCIBLE NITRIC OXIDE SYNTHASE
    Publication number: 20150147338
    Abstract: Aspects of the invention provide methods for treatment of a disease associated with elevated iNOS including autoimmune, chronic inflammatory, neurodegenerative, or cardiovascular diseases. In particular, aspects of the invention relate to the use of a therapeutic formulation comprising a galacto-rhamnogalacturonate for the treatment of a disease associated with elevated iNOS including autoimmune, chronic inflammatory, neurodegenerative, or cardiovascular diseases.
    Type: Application
    Filed: June 6, 2013
    Publication date: May 28, 2015
    Inventors: Peter G. Traber, Eliezer Zomer, Anatole A. Klyosov
  • Use of lipid conjugates in the treatment of diseases of the nervous system
    Patent number: 9040078
    Abstract: The invention provides a method for treating a subject suffering from a disease of the central nervous system which is associated with an inflammatory response, including, inter alia, multiple sclerosis, Amyotrophic Lateral Sclerosis (ALS), meningitis, Alzheimer's disease, pain, HIV-associated dementia, stroke, traumatic brain injury, encephalomyelitis, chronic inflammatory demyelinating polyneuropathy, cerebral ischemia-induced injury or any combination thereof. This invention further provides for the use of a conjugate, or composition comprising the same, for treating the subject, wherein the conjugate comprises a lipid or phospholipid moiety bonded to a physiologically acceptable monomer, dimer, oligomer, or polymer.
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: May 26, 2015
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventor: Saul Yedgar
  • EFFICIENT PRODUCTION OF OLIGOSACCHARIDES USING METABOLICALLY ENGINEERED MICROORGANISMS
    Publication number: 20150141370
    Abstract: The present invention relates to the enzymatic synthesis of oligosaccharides, particularly, sialylated oligosaccharides comprising the carbohydrate moeities of the gangliosides GM3, GD3, and GT3.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 21, 2015
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventor: Eric SAMAIN
  • INHIBITION OF TNF-ALPHA INDUCED ACTIVATION OF NFKB BY PENTOSAN POLYSULFATE
    Publication number: 20150141369
    Abstract: Oral pentosan polysulfate (PPS) compositions treat diseases such as diabetes, inflammation, atherosclerosis. The compositions are also effective in reducing matrix metalloproteinases (MMPs).
    Type: Application
    Filed: September 19, 2014
    Publication date: May 21, 2015
    Inventors: Gary E. Striker, Helen Vlassara, Feng Zheng
  • CHITOSAN WOUND DRESSING AND ITS METHOD OF MANUFACTURING
    Publication number: 20150135644
    Abstract: A wound dressing comprising acylated chitosan fibre. The dressing has a wet strength of 0.3 N/cm or above. The acylated chitosan fibre may have a degree of substitution of 0.10-0.50. The acylated chitosan fibre may preferably have a degree of substitution of 0.20-0.40. The dressing may have an absorbency of 5-25 g/g of a solution containing 8.298 g/l of sodium chloride and 0.368 g/l of calcium chloride dehydrate as measured by BSEN 13726-12002 Part 1 Aspects of Absorbency. The base material of the dressing may be chitosan fibre that has been chemically modified through an acylation process using anhydride and ethanol as the solvent. A method of manufacturing the wound dressing involves reacting chitosan fibre with anhydride and making acylated chitosan felt through a nonwoven process, and through cutting, packing and sterilizing processes.
    Type: Application
    Filed: January 17, 2012
    Publication date: May 21, 2015
    Inventors: Xiaohui Mo, Xiaodong Wang, Zhenjun Wu
  • PRESERVED COMPOSITIONS CONTAINING HYALURONIC ACID OR A PHARMACEUTICALLY-ACCEPTABLE SALT THEREOF AND RELATED METHODS
    Publication number: 20150141368
    Abstract: The invention provides a composition containing hyaluronic acid (HA) or a pharmaceutically-acceptable salt thereof preserved with a cationic preservative and related methods. In one embodiment, the pharmaceutically-acceptable salt is sodium hyaluronate.
    Type: Application
    Filed: November 21, 2013
    Publication date: May 21, 2015
    Applicant: MCNEIL-PPC, INC.
    Inventors: Uday Doshi, Kenneth T. Holeva
  • ANTI-BACTERIAL APPLICATIONS OF POLY-N-ACETYLGLUCOSAMINE NANOFIBERS
    Publication number: 20150140045
    Abstract: Described herein are compositions comprising shortened fibers of poly-N-acetylglucosamine and/or a derivative thereof (“sNAG nanofibers”) and anti-bacterial applications of such compositions. The sNAG nanofibers may be formulated into compositions for the prevention and/or treatment of bacterial infections and diseases associated with such infections. Regimens employing such compositions are also described.
    Type: Application
    Filed: July 9, 2014
    Publication date: May 21, 2015
    Inventors: John N. Vournakis, Sergio Finkielsztein
  • Ophthalmic composition
    Patent number: 9034843
    Abstract: The present invention provides an ophthalmic composition which stabilizes the tear film during wearing contact lens, prevents eye dryness, imparts a favorable sensation in using, is highly convenient with no risk of misuse and shows a high efficiency in the course from manufacturing to sales. More specifically, the present invention provides a wetting solution—eye drops for contact lenses comprising (A) one or more member(s) selected from the group consisting of a cellulose-based polymer, a vinyl-based polymer, polyethylene glycol and dextran; and (B) one or more member(s) selected from the group consisting of chondroitin sulfate, alginic acid and salts thereof; and (C) a nonionic surfactant.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: May 19, 2015
    Assignee: Rohto Pharmaceutical Co., Ltd.
    Inventors: Yasuko Matsumura, Kazuhiro Fukushima
  • 6?-sialyllactose salts and process for their synthesis and for the synthesis of other alpha-sialyloligosaccharides
    Patent number: 9034844
    Abstract: The present invention relates to a process of synthesis of ?-sialyl oligosaccharides and in particular of 6?-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: May 19, 2015
    Assignee: INALCO S.P.A.
    Inventors: Giancarlo Tamerlani, Ilaria Lombardi, Debora Bartalucci, Andrea Danesi, Liana Salsini, Marco Manoni, Giovanni Cipolletti
  • COMPOSITION AND USES OF GALECTIN ANTAGONIST
    Publication number: 20150133399
    Abstract: The present invention is directed to methods and compositions for augmenting treatment of cancers and other proliferative disorders. In particular embodiments, the invention combines the administration of an agent that inhibits the anti-apoptotic activity of galectin-3 (e.g., a “galectin-3 inhibitor”) so as to potentiate the toxicity of a chemotherapeutic agent. In certain preferred embodiments, the conjoint therapies of the present invention can be used to improve the efficacy of those chemotherapeutic agents whose cytotoxicity is influenced by the status of an anti-apoptotic Bcl-2 protein for the treated cell. For instance, galectin-3 inhibitors can be administered in combination with a chemotherapeutic agent that interferes with DNA replication fidelity or cell-cycle progression of cells undergoing unwanted proliferation.
    Type: Application
    Filed: December 18, 2014
    Publication date: May 14, 2015
    Inventors: Yan Chang, Vodek Sasak
  • THEACRINE-BASED SUPPLEMENT AND METHOD OF USE THEREOF
    Publication number: 20150132280
    Abstract: A human dietary supplement comprises theacrine and optionally other compounds that modulate the effects of theacrine. Uses for the theacrine-containing supplement include improvement of at least one of mood, energy, focus, concentration or sexual desire or a reduction of at least one of anxiety or fatigue.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 14, 2015
    Applicant: ORTHO-NUTRA, LLC
    Inventors: Hector L Lopez, Shawn Wells, Tim N. Ziegenfuss
  • COMPOSITION USING CROSS-LINKED HYALURONIC ACID FOR TOPICAL COSMETIC AND THERAPEUTIC APPLICATIONS
    Publication number: 20150132237
    Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 14, 2015
    Inventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
  • Prebiotic Formulations and Methods of Use
    Publication number: 20150133398
    Abstract: The invention provides methods and compositions for treating symptoms associated with lactose intolerance and for overall improvement in gastrointestinal health. Described herein are methods and compositions for improving overall gastrointestinal health or for decreasing symptoms of lactose intolerance by administering to subject in need thereof a prebiotic composition, optionally in combination with effective amount of a probiotic microbe or microbes.
    Type: Application
    Filed: September 12, 2014
    Publication date: May 14, 2015
    Inventors: Andrew J. Ritter, Dennis Savaiano, David Barnes, Todd Klaenhammer
  • Method and mixture for treating and preventing inflammatory bowel disease
    Patent number: 9029347
    Abstract: A method and a mixture for treating and preventing the inflammatory bowel disease (IBD) by applying a predetermined therapeutically effective amount of a mixture of hyaluronic acid to individuals is disclosed. The mixture includes at least two different average molecular weight hyaluronic acids (Mw) with different rheology to gain a hyaluronic acid with the proper adhesion property, functions of tissue scaffold and insulation and treatment time, in order to treat and to prevent IBD (inflammatory bowel disease) includes ulcerative colitis, Crohn's disease or wound healing in stomach and intestine, thus to achieve the prompt treatment and to prolong the effect.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: May 12, 2015
    Assignee: Holy Stone Healthcare Co., Ltd.
    Inventor: Tsung-Chung Wu
  • Compositions for the treatment of hemorrhoids and related diseases
    Patent number: 9028883
    Abstract: The present invention relates to pharmaceutical, nutraceutical, health foods and medical device compositions comprising polysaccharides from Opuntia Ficus Indica cladodes in combination with antioxidant and anti-inflammatory plant extracts as well as those from Olive leaf, Capparis Spinosa buttons, anthocianosides from red oranges, black rice or from other natural sources and their combinations, useful for prevention and therapy of hemorrhoidal disease and related diseases. The invention compositions may, be applied topically or administered by oral route.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: May 12, 2015
    Assignee: Bionap Srl
    Inventors: Luisa Rizza, Salvatore Munafo, Alberto Serraino
  • Bioadhesive for tissue repair
    Patent number: 9029349
    Abstract: The invention provides a bioadhesive composition comprising a polysaccharide and an energy converter, wherein the energy converter is activated by non-UV light. The composition may be prepared by dissolving the polysaccharide and the energy converter in an aqueous acidic solution. The composition, in the form of a film or a gel, may be used for repairing a discontinuity in an area of tissue or for joining tissue.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: May 12, 2015
    Inventors: Antonio Lauto, Laura Poole-Warren, Leslie John Ray Foster
  • Cosmetic
    Patent number: 9023830
    Abstract: There is disclosed a cosmetic comprises a sugar compound obtained by reacting a hydroxyl group of a saccharide, an isocyanate group-containing organopolysiloxane represented by the following general formula (1), and an isocyanate group-containing organic compound represented by the following general formula (2). As a result, there is provided a cosmetic excellent in cosmetic sustainability and storage stability that can improve such undesirable feelings of use as insufficient spreadability and stickiness, improve the solubility to not only a non-polar oil such as a silicone oil and a light liquid paraffin, but also a polar oil such as a UV-absorber, an ester oil, and a natural animal and vegetable oil, provides non-stickiness with a cosmetic containing the polar oil, and prevent adhesion of the cosmetic to clothes (secondary adhesion).
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: May 5, 2015
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventor: Masanao Kamei
  • Method of using shaped articles to apply a scaffold-forming agent to an external skin and/or hair surface of a human or an animal
    Patent number: 9023333
    Abstract: The invention relates to the use of a shaped article containing at least one skeleton-forming agent, proteins being excepted, optionally one or more active substances and also optionally one or more auxiliary substances for the purpose of external application, to a process for producing the stated shaped articles, and also to novel shaped articles.
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: May 5, 2015
    Inventors: Stefan Frahling, Ralf Malessa
  • Methods and compositions of inhibiting complement and cellular activation with Dextran Sulfate
    Patent number: 9023831
    Abstract: A method of inhibiting the adverse effects of complement pathway, activation products in a subject comprising administering to the subject an amount of Dextran Sulfate effective to inhibit formation of alternative complement pathway activation product.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: May 5, 2015
    Assignee: Novelmed Therapeutics, Inc.
    Inventor: Rekha Bansal
  • Active ingredient with cutaneous application obtained from metschnikowia agaves and uses for improving the state of the skin
    Patent number: 9023827
    Abstract: An active ingredient with cutaneous application obtained from Metschnikowia agaves, as well as its use for preventing and/or combating ageing of the skin and its visible manifestations, and cosmetic compositions including this active ingredient and to a cosmetic process for skin care.
    Type: Grant
    Filed: April 10, 2013
    Date of Patent: May 5, 2015
    Assignee: Societe Industrielle Limousine d'Application Biologique
    Inventor: Jean Paufique
  • Composition comprising at least one alginate for use in treatment and/or prevention of overweight
    Patent number: 9023828
    Abstract: The present invention relates to a composition in the form of a powder or a viscous paste, and which includes at least one low viscosity alginate having a viscosity of less than about 100 mPaS in a 1 wt % aqueous solution, and at least one high viscosity alginate having a viscosity of more than about 100 mPaS in a 1 wt % aqueous solution. The composition can also include at least one suspending agent. The composition is readily soluble in water such that an aqueous preparation can be prepared without substantive mixing. Also, the aqueous preparation is suitable for use in the treatment and/or prevention of overweight for both therapeutic and non-therapeutic purposes.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: May 5, 2015
    Assignee: S-Biotek af 15. Marts 2006 1 ApS
    Inventors: Finn Larsen, Brian Malm, Jens Steen Olsen
  • Ophthalmic Viscoelastic Device
    Publication number: 20150119356
    Abstract: The invention relates to an ophthalmic viscoelastic device, comprising at least one viscoelastic polymer, wherein the at least one viscoelastic polymer is covalently bound to at least one phenolic compound. The invention also relates to a method for producing an ophthalmic viscoelastic device, in which at least one phenolic compound is covalently bound to at least one water-soluble, viscoelastic polymer.
    Type: Application
    Filed: May 8, 2013
    Publication date: April 30, 2015
    Applicant: Carl Zeiss Meditec AG
    Inventors: Andre Wolfstein, Gillian Rodden, Jurgen Nachbaur, Claude De Moissonnier, Pascal Bernard, Gildas Lorec, Nicole Bielefeldt, Brian Rathert, Lidia Nachbaur, Mario Gerlach, Alistair Rennie
  • POLYSACCHARIDES FROM PRASINOCOCCALES
    Publication number: 20150119355
    Abstract: There is provided a composition comprising a polysaccharide obtainable from the microalgae, Prasinococcus capsulatus and strains related to P. capsulatus for use prophylactically and/or therapeutically in the treatment of disorders of the immune system, for example in psoriasis and dermatological conditions, internal immune system disorders, in particular gut inflammatory conditions and respiratory conditions. Further, there is provided derivatives of a polysaccharide obtainable from the microalgae, Prasinococcus capsulatus or an algal strain related to P. capsulatus and the use of such derivatives prophylactically and/or therapeutically in the treatment of disorders of the immune system.
    Type: Application
    Filed: May 13, 2013
    Publication date: April 30, 2015
    Inventors: Charles Daniel Bavington, Claire Moss
  • Prebiotic Formulations and Methods of Use
    Publication number: 20150118297
    Abstract: The invention provides methods and pharmaceutical compositions for treating symptoms associated with lactose intolerance and for overall improvement in gastrointestinal health. Described herein are methods and pharmaceutical compositions for improving overall gastrointestinal health or for decreasing symptoms of lactose intolerance by administering to subject in need thereof a pharmaceutical composition comprising a prebiotic, optionally in combination with effective amount of a probiotic microbe or microbes.
    Type: Application
    Filed: June 2, 2014
    Publication date: April 30, 2015
    Applicant: RITTER PHARMACEUTICALS, INC.
    Inventors: Andrew J. Ritter, Dennis Savaiano, David Barnes, Todd Klaenhammer
  • MOENOMYCIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF
    Publication number: 20150119354
    Abstract: The present invention provides compounds of Formula (I); or a pharmaceutically acceptable form thereof; wherein R1,R2,R3,R6,R7,R12,Ra, and Rb are as defined herein, and G is a group of Formula (a), (b), or (c): Formula (II), wherein X1; X2, X3, X4, X5, X6, X7, Y, RC, Rd, Rz, a, d, e, x, n, and m are as defined herein. The present invention further provides pharmaceutical compositions comprising a compound of Formula (I), kits comprising such compositions, methods of use and treatment, and preparative methods.
    Type: Application
    Filed: April 5, 2013
    Publication date: April 30, 2015
    Inventors: Daniel Evan Kahne, Suzanne Walker Kahne, Hirokazu Tsukamoto
  • Compositions and Methods For Modulation of Vascular Structure and/or Function
    Publication number: 20150118281
    Abstract: The present invention relates to compositions comprising semi-crystalline ?-1-4-N-acetylglucosamine polymers (p-GlcNac) and methods utilizing such polymers modulation of vascular structure and/or function. The compositions and methods disclosed are useful for stimulating, in a p-GlcNac concentration-dependent manner, endothelin-1 release, vasoconstriction, and/or reduction in blood flow out of a breached vessel, as well as for contributing to or effecting cessation of bleeding. The methods of the present invention comprise topical administration of materials comprising semi-crystalline p-GlcNac polymers that are free of proteins, and substantially free of single amino acids as well as other organic and inorganic contaminants, and whose constituent monosaccharide sugars are attached in a ?-1-4 conformation.
    Type: Application
    Filed: September 5, 2014
    Publication date: April 30, 2015
    Inventors: John N. Vournakis, Sergio Finkielsztein
  • ANTIMICROBIAL COMPOSITIONS, THE PREPARATION AND USE THEREOF
    Publication number: 20150119353
    Abstract: The present teachings provide new compositions comprising polycations and polycations, and the preparation and use of these new compositions, In one aspect, the new compositions are complex coacervates. The compositions described herein can have several desired properties, including, low interfacial tension in water, adjustable cohesive strength, antimicrobial activity, suitability for dissolution at or near physiological pH, the ability to promote cell attachment, biocompatiblility, and/or biodegradability. Thus, in various embodiments, the complex coacervates can be used in water-based applications, for example, in the body.
    Type: Application
    Filed: February 21, 2013
    Publication date: April 30, 2015
    Inventor: Neal Vail
  • Alginate oligomers for use in overcoming multidrug resistance in bacteria
    Patent number: 9018158
    Abstract: The invention provides a method of overcoming resistance to at least one antibiotic in a multidrug resistant bacterium, said method comprising contacting said bacterium with an alginate oligomer together with the antibiotic. The multidrug resistant bacterium may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with a multidrug resistant bacterium to overcome resistance to the antibiotic in said multidrug resistant bacterium. In another aspect the method can be used to combat contamination of a site with multidrug resistant bacteria, e.g. for disinfection and cleaning purposes.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: April 28, 2015
    Assignee: Algipharma AS
    Inventors: Edvar Onsoyen, Rolf Myrvold, Arne Dessen, David Thomas, Timothy Rutland Walsh
  • Bonding products of aminated polysaccharides
    Patent number: 9018372
    Abstract: The invention relates to a bonding product comprising at least the polysaccharides T1 and T2, characterized in that a) the monosaccharides from which the polysaccharides T1 and T2 are constructed are partially or completely bonded to each other alpha-1,4-glycosidically and b) at least one of the polysaccharides T1 and/or T2 comprises at least one amino group and c) T1 and T2 are chemically bonded to each other covalently by at least one linker Z and d) T1 and/or T2 carries m groups -(L-A), wherein A is an active pharmaceutical ingredient and/or a fluorescence label, L is a second linker, by which T1 and/or T2 is covalently bonded to A, and m is an integer, which is 0 or at least 1.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: April 28, 2015
    Assignee: B. Braun Melsungen AG
    Inventors: Bernd Horst Meier, Iris Jankowiak-Meier, Nele Meier, Clara Meier
  • PESTICIDAL COMPOSITIONS AND RELATED METHODS
    Publication number: 20150111732
    Abstract: A pesticidal composition comprises a 3-(1H-pyrazol)pyridine compound of formula I or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R9, R10, R12, x, n, and Q are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Martin J. Walsh, Ann M. Buysse, Asako Kubota, Noormohamed M. Niyaz, Yu Zhang, Ricky Hunter, Tony K. Trullinger
  • GLUCAN FIBRE
    Publication number: 20150111848
    Abstract: Method for preparing a branched glucan having a chain comprising a plurality of glucose units linked by alpha 1,4-glycoside bonds and a plurality of side-groups linked to said chain via another type of glycoside bonding, which side-groups comprise one or more glucose units, the method comprising contacting a glucose source with a polysaccharide—which polysaccharide is a glucan comprising a plurality of glucose units linked by alpha 1,4-glycoside bonds and is essentially linear or branched to a lesser extent than the branched glucan that is to be prepared—in the presence of an acid catalyst under polycondensation conditions, thereby forming the branched glucan.
    Type: Application
    Filed: May 21, 2013
    Publication date: April 23, 2015
    Inventors: Maurice Karel Hubertina Essers, Johannes Wilhelmus Timmermans, Jerome Villarama Diaz, Ronald Tako Marinus van den Dool, Theodoor Maximiliaan Slaghek
  • PESTICIDAL COMPOSITIONS AND RELATED METHODS
    Publication number: 20150111730
    Abstract: A pesticidal composition comprises a compound of formula I or any agriculturally acceptable salt thereof, wherein R1, R2, R4, R5, R6, R7, Z, Q, and Y are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests, or to an area to control pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Noormohamed M. Niyaz, Ann M. Buysse, David A. Demeter, Negar Garizi, Ricky Hunter, Daniel Knueppel, Paul R. LePlae, Christian T. Lowe, Akshay Patny, Tony K. Trullinger, Martin J. Walsh, Yu Zhang
  • PESTICIDAL COMPOSITIONS AND RELATED METHODS
    Publication number: 20150111731
    Abstract: A pesticidal composition comprises one or more of the following compounds: 3-(thiazol-2-yl)pyridine 1-oxide compound of formula I or II, or N-(4-chloro-2-(pyridin-3-yl)thiazol-5-yl)-3-(methylthio)propanamide compound (C3), or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, and Q, are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Negar Garizi, Martin J. Walsh, Ann M. Buysse, Daniel Knueppel, Asako Kubota, Noormohamed M. Niyaz, Yu Zhang, Ricky Hunter, Tony K. Trullinger
  • PESTICIDAL COMPOSITIONS AND RELATED METHODS
    Publication number: 20150111734
    Abstract: A pesticidal composition comprises at least one compounds selected from a compound of formula, or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, Q, Z, L, La, and x are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Yu Zhang, Asako Kubota, Noormohamed M. Niyaz, Thomas Barton, Tony K. Trullinger, Christian T. Lowe, Paul R. LePlae, Ann M. Buysse, Martin J. Walsh, Negar Garizi, Ricky Hunter, Daniel Knueppel
  • BIPHASIC OSTEOCHONDRAL SCAFFOLD FOR RECONSTRUCTION OF ARTICULAR CARTILAGE
    Publication number: 20150110846
    Abstract: An osteochondral scaffold has a chondrogenic spiral scaffold in one end of an outer shell made of sintered microspheres, and an osteogenic spiral scaffold in the other end of the outer shell. Each spiral scaffold has nanofibers of a composition selected to promote attachment and proliferation of the desired types of cells. The nanofibers for the chondrogenic spiral scaffold have a different composition than the nanofibers for the osteogenic spiral scaffold. The nanofibers of each spiral scaffold are aligned to orient the attached cells so as to recreate the structure of the native tissue.
    Type: Application
    Filed: March 14, 2013
    Publication date: April 23, 2015
    Applicant: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY
    Inventors: Xiaojun Yu, Paul Lee
  • PESTICIDAL COMPOSITIONS AND RELATED METHODS
    Publication number: 20150111733
    Abstract: A pesticidal composition comprises at least one compound selected from a 1-(3-pyridyl-N-oxide)pyrazole compound of formula I, II, or III, or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R12, R13, Y, and Q, are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Martin J. Walsh, Daniel Knueppel, Noormohamed M. Niyaz, Ann M. Buysse, Negar Garizi, Asako Kubota, Yu Zhang, Ricky Hunter, Tony K. Trullinger
  • Photo-crosslinked gellan gum-based hydrogels: preparation methods and uses thereof
    Patent number: 9012415
    Abstract: This invention refers to photo-crosslinked hydrogel materials based in gellan gum suitable for tissue engineering and regenerative medicine applications or as drug delivery systems. Formulations of gellan gum with different degrees of acylation serve as precursor material for insertion of a polymerizable moiety. The materials are capable of free radical polymerization with a photo-initiator at mild temperatures and exposure to ultraviolet light, enabling control of reticulation and withstanding the encapsulation of human and animal cells and/or drugs, and any combination thereof. The physicochemical and biological properties can be adjusted by combining different formulations of gellan gum and reaction conditions.
    Type: Grant
    Filed: March 26, 2011
    Date of Patent: April 21, 2015
    Assignee: Stemmatters, Biotecnologia e Medicina Regenerativa S.A.
    Inventors: Joana Catarina Da Silva Correia, Joaquim Miguel Antunes De Oliveira, João Manuel Teixeira De Oliveira, Rui Pedro Amandi Romero De Sousa, Rui Luis Gonçalves Dos Reis
  • Sterile hyaluronic acid polymer compositions and related methods
    Patent number: 9011894
    Abstract: The present application provides sterile hyaluronic polymer compositions than are useful, e.g., as medical devices, biomedical adhesives, and sealants. Generally, provided are sterile dry compositions comprising a thiol-derivatized hyaluronic acid and one or more stabilizing excipients. Also provided are related kits and methods. The compositions described herein are particularly robust to sterilizing irradiation, and substantially maintain both their molecular weight and gelation parameters such as gelation time after sterilization, such that such sterile compositions are capable of hydrogel formation.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: April 21, 2015
    Assignee: Carbylan Therapeutics, Inc.
    Inventors: George Y. Daniloff, Robert C. Spiro, David M. Gravett, Patrick J. Hillas, Pingren He
  • FGF receptor-activating N-acyl octasaccharides, preparation thereof, and therapeutic use thereof
    Patent number: 9012413
    Abstract: The invention relates to FGF receptor-activating N-acyl octasaccharides having Formula (I), wherein: R1 is an O-alkyl group optionally replaced by one or more aryl or cycloalkyl groups, R2 is an OSO3? or hydroxyl group, R3 is an alkyl, cycloalkyl, or alkyl-cycloalkyl group, R4 is a disaccharide having Formula (II), R6 is a disaccharide having Formula (III), and R8 is a disaccharide having Formula (IV), where R5, R7, and R9 are OSO3? or hydroxyl groups. The invention further relates to the preparation of said octasaccharides and to the therapeutic use thereof.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: April 21, 2015
    Assignee: Sanofi
    Inventors: Pierre Alexandre Driguez, Philippe Duchaussoy, Pierre Fons, Corentin Herbert, Gilbert Lassalle
  • Use of lipid conjugates in the treatment of conjunctivitis
    Patent number: 9012396
    Abstract: In one embodiment, the invention provides a method of suppressing, inhibiting, preventing, or treating conjunctivitis in a subject, comprising the step of administering an effective amount of a lipid or phospholipid moiety bound via an ester or amide bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof to a subject with conjunctivitis.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: April 21, 2015
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem
    Inventor: Saul Yedgar
  • USES OF ANTAGONISTS OF HYALURONAN SIGNALING
    Publication number: 20150105345
    Abstract: Described herein is the finding that hyaluronan antagonists that inhibit hyaluronan signaling are capable of inhibiting airway inflammation and airway hyperresponsiveness (AHR). The present disclosure provides a method of preventing or reducing AHR in a subject suffering from or at risk for AHR by administering a hyaluronan antagonist. Also provided is a method of treating an airway disease or disorder in a subject by administering a hyaluronan antagonist. Hyaluronan antagonists include, for example, heparosan and hyaluronan oligosaccharides (oHAs). In some embodiments, the hyaluronan antagonist is administered locally to the airway, such as with an inhaler or nebulizer.
    Type: Application
    Filed: March 8, 2013
    Publication date: April 16, 2015
    Applicants: The United States of America, as represented by the Secretary, Dept. of Health and Human Services, Duke University, MUSC Foundation for Research Development, The Universtiy of North Carolina at Chapel Hill
    Inventors: Stavros Garantziotis, John W. Hollingsworth, Bryan P. Toole, Jian Liu
  • TREATING MUCOSAL LESIONS WITH HYALURONAN DELIVERED FROM AN ADHERING TROCHE
    Publication number: 20150104509
    Abstract: A troche comprising at least 5 mg hyaluronan, wherein the troche is adherent, and wherein hyaluronan is released from the troche, is used to treat mucositis, including stomatitis, vestibulitis, aphthous ulcerations, lichen planus and Behcet's syndrome. A method for treating or preventing mucositis in a patient is provided, comprising applying to a mucosal surface or a tooth or orthodontic brace of a patient in need thereof an adhering troche comprising at least 5 mg hyaluronan.
    Type: Application
    Filed: October 15, 2014
    Publication date: April 16, 2015
    Inventor: Jeffrey Haley
  • ALGIN OLIGOSACCHARIDES AND THE DERIVATIVES THEREOF AS WELL AS THE MANUFACTURE AND THE USE OF THE SAME
    Publication number: 20150105344
    Abstract: The invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of ?-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedure that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2˜6 and the temperature of 100˜120° C., and adjusted pH to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.
    Type: Application
    Filed: September 10, 2014
    Publication date: April 16, 2015
    Inventors: Meiyu Geng, Huashi Guan, Xianliang Xin, Zhao Yang, Guangqiang Sun
  • Agent for treatment of dry eye characterized by combining P2Yreceptor agonist and hyaluronic acid or salt thereof, method for treating dry eye, and use of the P2Yreceptor agonist and hyaluronic acid or salt thereof
    Patent number: 9006208
    Abstract: An agent for treatment of dry eye comprising a combination of a P2Y2 receptor agonist at a therapeutically effective concentration and hyaluronic acid or a salt thereof at a therapeutically effective concentration, which agent has a dosage form of an ophthalmic agent, can promote the secretion of tear remarkably and can improve corneal epithelial disorders remarkably, and is therefore expected to be a novel agent for treatment of dry eye.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: April 14, 2015
    Assignee: Santen Pharmaceutical Co., Ltd.
    Inventors: Yuko Shichijo, Atsuyoshi Dota, Takashi Nagano, Masatsugu Nakamura, Asuka Sakamoto
  • Composition for a topical ophthalmic clear colloidal liquid which undergoes a liquid-gel phase transition in the eye
    Patent number: 9006214
    Abstract: The present invention is directed to a topical ophthalmic composition for a liquid comprised of clear colloidal polar nanolipids delivered in submicron sized particles, aqueous colloidal lubricants, aqueous polymers, emulsifies, and a unique stabilizing buffer system, which undergoes a liquid-gel phase transition in the eye. Said composition is designed to deliver advanced eye lubricants, protect the three (3) layers of corneal film from dryness, and provide a unique system of Dry Eye treatment that addresses and treats all three layers of corneal tear film. Said composition is further designed to provide a superior delivery system of various Active Pharmaceutical Ingredients (APIs), and/or anti-infective/antibiotic/anti-fungal agents, accepted as safe and efficacious for ophthalmic use.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: April 14, 2015
    Assignee: Altaire Pharmaceutical, Inc.
    Inventor: Assad S. Sawaya
  • Injectable cross-linked polymeric preparations and uses thereof
    Patent number: 9006213
    Abstract: A therapeutic composition for treatment of a body tissue which includes an aqueous solution of a cross-linked polymer being capable of: (i) maintaining a liquid state in storage at room temperature for at least 24 hours; and (ii) assuming a gel state following deposition within the body tissue. The therapeutic composition can be effectively administered into a damaged body tissue via injection or catheterization, thereby treating the damaged body tissue.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: April 14, 2015
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Smadar Cohen, Jonathan Leor
  • Compositions and methods for pest control
    Patent number: 9006212
    Abstract: Provided herein are compositions and kits comprising carbohydrate-based inhibitors that bind GNBP and/or inhibit ?(1,3)-glucanase activity. Also provided are methods of using such inhibitors to protect against or treat pest infestation, as are compositions and kits comprising subparts of the carbohydrate-based inhibitors.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: April 14, 2015
    Assignees: Massachusetts Institute of Technology, Northeastern University
    Inventors: Ido Bachelet, Ram Sasisekharan, Mark Bulmer, Rebeca B. Rosengaus