Sulfur Nonionically Bonded Patents (Class 514/562)
-
Patent number: 8859509Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.Type: GrantFiled: May 13, 2009Date of Patent: October 14, 2014Assignee: Yale UniversityInventors: David Spiegel, Ryan Murelli, Andrew Zhang
-
Patent number: 8859620Abstract: The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to treat bacterial infections, or to inhibit or kill bacteria, either in vitro or in vivo.Type: GrantFiled: August 31, 2010Date of Patent: October 14, 2014Assignee: University of Notre Dame du LacInventors: Shahriar Mobashery, Dusan Hesek, Mayland Chang
-
Publication number: 20140303122Abstract: By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: March 28, 2014Publication date: October 9, 2014Applicant: AJINOMOTO CO., INC.Inventors: Masayuki SUGIKI, Toru Okamatsu, Sayaka Asari, Yayoi Kawato, Toshihiro Hatanaka, Tetsuo Yano, Yukie Seki, Naohiro Miyamura, Hiroaki Nagasaki, Yuzuru Eto, Reiko Yasuda
-
Patent number: 8853274Abstract: A composition including a farnesyl transferase inhibitor (FTI) and a gamma-secretase inhibitor (GSI) is useful for producing an effect against a glioblastoma cell and/or for treating glioblastoma multiforme (GBM).Type: GrantFiled: September 14, 2012Date of Patent: October 7, 2014Assignee: Vanderbilt UniversityInventor: Jialiang Wang
-
Publication number: 20140296270Abstract: Small molecule inhibitors of Stat3 and their derivatives are disclosed. Also described are methods to inhibit cell growth by use of Stat3 inhibitors, and the use of Stat3 inhibitors for the prevention and/or treatment of cancer. Further, inhibitors of Stat3 that also do not inhibit Stat1 are described as well as their derivatives. Methods of screening additional compounds for Stat3 inhibition activity and/or non-inhibition of Stat1 activity are also described herein.Type: ApplicationFiled: April 15, 2014Publication date: October 2, 2014Applicant: Baylor College of MedicineInventors: David J. Tweardy, Xuejun Xu, Moses M. Kasembeli
-
Publication number: 20140288177Abstract: The present invention concerns compositions and methods related to utilizing glycine and N-acetylcysteine for a variety of methods, including, for example, reducing deleterious effects of oxidative stress; treating and/or preventing diabetes; and/or increasing GSH levels.Type: ApplicationFiled: May 15, 2014Publication date: September 25, 2014Applicant: Baylor College of MedicineInventor: Rajagopal V. Sekhar
-
Patent number: 8840892Abstract: The present invention describes the use of immunomodulators to support the usual treatment against infectious diseases caused by facultative intracellular organisms. Starting from an analysis of the immune response installed in this type of infection, particularly the infection caused by Tuberculosis, a treatment kit is used that associates a soluble betaglycan type immunomodulator, associated with an anti-inflammatory agent of the prostaglandin E blocking type, which, when used together, modulate the immune response, thus permitting a shortening in treatment time with the respective antibiotics.Type: GrantFiled: May 12, 2004Date of Patent: September 23, 2014Assignee: Universidad Nacional Autónoma de MéxicoInventors: Rogelio Hernandez Pando, Fernando Lopez Casillas
-
Publication number: 20140271926Abstract: A method of treating neoplastic growth in a subject includes administering a glutamine synthetase (GS) inhibitor to the subject having neoplastic growth. A glutamine synthetase inhibitor may be administered in combination with thalidomide, lenalidomide and/or pomalidomide. Responsiveness to thalidomide, lenalidomide or pomalidomide therapy is determined by the expression levels of glutamine synthetase in neoplastic cells.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Inventors: Thang V. Nguyen, Raymond J. Deshaies
-
Publication number: 20140275257Abstract: The described invention provides a method and kit for treating a lupus condition with N-acetyl-L-cysteine (NAC) compositions that improve lupus disease activity driven by a decrease in the activity of the mammalian target of rapamycin (mTOR). The compositions of the described invention is effective to: (1) reduce fatigue; (2) reduce cognitive/inattentive component of attention deficit and hyperactivity (ADHD) self-report scale (ASRS); (3) reduce inflammation, for example, as measured by the systemic lupus erythematosus disease activity index (SLEDAI), and the British Isles Lupus Assessment Group (BILAG) score; (4) modulate mitochondrial potential and (5) reduce T cell cycle dysfunction driven by a decrease in the activity of the mammalian target of rapamycin (mTOR) in patients suffering from systemic lupus erythematosus (SLE).Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Inventor: Andras Perl
-
Publication number: 20140271831Abstract: A liquid composition comprising racecadotril and cyclodextrin.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Applicant: McNeil-PPC, Inc.Inventor: Der-Yang Lee
-
Patent number: 8835497Abstract: A food composition that is useful for increasing antioxidant levels in the body is provided having increased levels of sulfur-containing amino acids, such as methionine, cysteine, or mixtures thereof. Methods of using these compositions for increasing antioxidant levels in the body in mammals, especially in companion animals, are also provided.Type: GrantFiled: May 24, 2010Date of Patent: September 16, 2014Assignee: Hill's Pet Nutrition, Inc.Inventors: Kim Gene Friesen, Dennis Edward Jewell
-
Patent number: 8835498Abstract: Provided are anti-wrinkle agents having a novel scaffold that is suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), stereoisomers thereof, or pharmacologically acceptable salts thereof. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that are caused by skin aging with increased age or occur as a result of photoaging due to ultraviolet rays exposure. [In the formula, R1 represents a hydrogen atom or a 1 to 8 carbon straight or branched alkyl group. R2 represents —SH, —SO3H, —S—S—X1, —S—X2, —SO—X3, —SO2—X4, —SO2—NY1—X5 or —SO2—NY2—Y3. X1-X5 independently are hydrogen atoms or 1 to 8 carbon aliphatic hydrocarbon groups or 5 to 12 carbon aromatic moiety wherein carbon atoms may be substituted with heteroatoms. Y1 to Y3 independently represent hydrogen atoms or 1 to 8 carbon linear or branched alkyl groups.Type: GrantFiled: November 12, 2009Date of Patent: September 16, 2014Assignee: Pola Chemical Industries Inc.Inventors: Noriko Suenobu, Chihiro Kondo, Takashi Yamasaki
-
Publication number: 20140256816Abstract: The present invention relates to adamantyl derivatives and their anti-cancer activity. Compounds of formulae I and II are provided as well as related methods of treatment and methods of synthesis.Type: ApplicationFiled: April 16, 2014Publication date: September 11, 2014Applicant: Women & Infants' Hospital of Rhode IslandInventors: Richard G. Moore, Rakesh K. Singh
-
Patent number: 8822467Abstract: The present invention provides biaryl oxyacetic acid compounds which may be useful for treating inflammatory disorders, including disorders affecting the respiratory system and skin.Type: GrantFiled: December 14, 2012Date of Patent: September 2, 2014Assignee: Ligand Pharmaceuticals IncorporatedInventors: Brian F. McGuinness, Koc-Kan Ho, Suresh Babu, Guizhen Dong, Jingqi Duo, Thuy X. H. Le, Kurt W. Saionz
-
Publication number: 20140235569Abstract: Described herein is a method for increasing levels of S-adenosylmethionine within the human body without administering S-adenosylmethionine directly. The method of the invention may be achieved by administering one or more of L-methionine, methylcobalamin, 5-Methyl tetrahydrofolate, betaine, and malic acid, together with at least one compound selected from the group consisting of folic acid, vitamin B12, magnesium, calcium, and other cofactors.Type: ApplicationFiled: February 4, 2014Publication date: August 21, 2014Applicant: Fast Balance, Inc.Inventor: Brian D. Halevie-Goldman
-
Publication number: 20140235604Abstract: A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R1 is an aliphatic and/or aromatic compound.Type: ApplicationFiled: May 7, 2014Publication date: August 21, 2014Inventors: Krzysztof Palczewski, Akiko Maeda, Marcin Golczak
-
Publication number: 20140235702Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having sulfonamido-1-hydroxynaphthalene structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.Type: ApplicationFiled: October 8, 2012Publication date: August 21, 2014Inventors: Zaneta Nikolovska-Coleska, Hollis D. Showalter, Chenzhong Liao, Ramzi Mohammad, Fardokht Abulwerdi
-
Publication number: 20140235717Abstract: A method is provided for the supplementation of milk, dairy products, meat products, and other food substances generally considered to be a major part of the Western diet, with substances capable of balancing the ratio of methionine and cysteine. Drug therapy with various carbamoyl thioesters or glutamate receptor antagonists can also be used, alone or in combination with dietary supplements and vitamins, to prevent or treat the pathology resulting from a Western diet.Type: ApplicationFiled: February 19, 2014Publication date: August 21, 2014Inventor: John V. Schloss
-
Patent number: 8809311Abstract: A process for improving the health of a subject, the process comprising orally administering a composition comprising hydroxytyrosol to the subject to provide the subject with a daily dose of about 0.1 to about 750 ?g hydroxytyrosol per kg of body weight, and a dietary supplement in dosage unit form for oral administration, the dosage unit form comprising a composition containing about 1 microgram to about 50 milligrams hydroxytyrosol or an ester or salt thereof.Type: GrantFiled: August 10, 2010Date of Patent: August 19, 2014Inventor: Darlene McCord
-
Publication number: 20140228302Abstract: Compositions and methods of treating or preventing disease or injury to a human patient or biological material undergoing ischemic or hypoxic conditions.Type: ApplicationFiled: February 5, 2014Publication date: August 14, 2014Applicant: FRED HUTCHINSON CANCER RESEARCH CENTERInventors: Fuqiang Ruan, Edward A. Winter, Thomas L. Deckwerth
-
Publication number: 20140228325Abstract: The present invention relates to alkene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.Type: ApplicationFiled: February 6, 2014Publication date: August 14, 2014Applicant: Allergan, Inc.Inventors: Wenkui K. Fang, Ken Chow, Evelyn G. Corpuz
-
Publication number: 20140228296Abstract: The present invention relates to the discovery that an increased fraction of albumin is carbamylated in patients suffering from kidney disease (e.g., end-stage renal disease) and that the fraction of carbamylated albumin is also correlated with increased disease severity, particularly risk of mortality. The present invention also relates to the discovery that free amino acids can reduce carbamylation of albumin. Based on these discoveries the present invention provides diagnostic and prognostic methods for patients suffering from, or suspected of suffering from kidney disease. The invention also provides methods for treating kidney disease by administration of a compound or composition that reduced protein carbamylation, such as free amino acids or dipeptides.Type: ApplicationFiled: July 13, 2012Publication date: August 14, 2014Applicant: Beth Israel Deaconess Medical Center, Inc.Inventors: Anders H. Berg, S. Ananth Karumanchi, Ravi I. Thadhani
-
Patent number: 8802730Abstract: The present invention concerns compositions and methods related to utilizing glycine and N-acetylcysteine for a variety of methods, including, for example, reducing deleterious effects of oxidative stress; treating and/or preventing diabetes; and/or increasing GSH levels.Type: GrantFiled: December 27, 2012Date of Patent: August 12, 2014Assignee: Baylor College of MedicineInventor: Rajagopal V. Sekhar
-
Publication number: 20140220122Abstract: The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compound that will yield or generate 3APS, either in vitro or in vivo.Type: ApplicationFiled: April 7, 2014Publication date: August 7, 2014Applicant: BHI Limited PartnershipInventors: Xianqi KONG, Mohamed ATFANI, Benoit BACHAND, Abderrahim BOUZIDE, Stephane CIBLAT, Sophie LEVESQUE, David MIGNEAULT, Isabelle VALADE, Xinfu WU, Daniel DELORME
-
Publication number: 20140221481Abstract: The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.Type: ApplicationFiled: April 10, 2014Publication date: August 7, 2014Applicant: Allergan, Inc.Inventors: HAIQING YUAN, RICHARD L. BEARD, XIAOXIA LIU, JOHN E. DONELLO, VEENA VISWANATH, MICHAEL E. GARST
-
Publication number: 20140206765Abstract: A pharmaceutical composition and method for providing a reduction in side effects for human patients in need of therapy comprising the administration of a pharmaceutical composition comprising acetylcysteine is disclosed.Type: ApplicationFiled: March 25, 2014Publication date: July 24, 2014Applicant: Cumberland Pharmaceuticals, Inc.Inventors: Leo Pavliv, Amy Rock
-
Publication number: 20140206693Abstract: Certain embodiments are directed to methods of treating a pathophysiological state or symptoms thereof resulting from aldose reductase-mediated signaling in a cytotoxic pathway using an aldose reductase specific inhibitor.Type: ApplicationFiled: January 27, 2014Publication date: July 24, 2014Applicant: The Board of Regents of the University of Texas SystemInventors: Satish K Srivastava, Kota V Ramana
-
Publication number: 20140206736Abstract: Composition comprising leucine, isoleucine, valine, threonine and lysine for use in prophylactic and/or therapeutic treatment of renal disorders in a subject, preferably an elderly subject.Type: ApplicationFiled: March 26, 2014Publication date: July 24, 2014Applicant: DETERMINANTS OF METABOLISM RESEARCH LABORATORY S.R.L.Inventors: Franco CONTI, Francesco Saverio DIOGUARDI
-
Publication number: 20140206741Abstract: The present invention provides an N-substituted isopropyldimethyl azulene sulfonamide derivative as represented by formula (I), and preparation method and uses thereof, wherein R1 is an alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, amino, or a substituted alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, and amino. The N-substituted isopropyldimethyl azulene sulfonamide derivative can be used in treating gastric ulcer.Type: ApplicationFiled: April 12, 2012Publication date: July 24, 2014Applicant: Sichuan Guokang Pharmaceutical Co., LtdInventors: Luyun Zhang, Fang Yang, Wanqi Shi, Ping Zhang, Ying Li, Shufan Yin
-
Publication number: 20140200275Abstract: A method for treating skin cancer including the steps of applying an isothiocyanate functional surfactant to an area affected by skin cancer, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.Type: ApplicationFiled: July 26, 2013Publication date: July 17, 2014Inventor: Michael E. Silver
-
Publication number: 20140200254Abstract: The present invention relates to pharmaceutical compositions comprising D-serine transporter inhibitors and therapeutic methods using such pharmaceutical compositions in methods for the treatment of central nervous system disorders.Type: ApplicationFiled: March 17, 2014Publication date: July 17, 2014Applicant: Allergan, Inc.Inventors: ALAN C. FOSTER, YONG-XIN Li, URSULA STAUBLI, VEENA VISWANATH, LAUREN LUHRS
-
Publication number: 20140194468Abstract: The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs, Stat3 phosphorylation and nuclear translocation, Stat3 transcriptional function, and consequently induced Stat3-specific antitumor cell effects in vitro and antitumor response in vivo.Type: ApplicationFiled: November 10, 2013Publication date: July 10, 2014Applicants: The Governing Council of the University of Toronto, University of Central Florida Research Foundation, Inc.Inventors: James Turkson, Patrick Gunning
-
Publication number: 20140194416Abstract: The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.Type: ApplicationFiled: March 11, 2014Publication date: July 10, 2014Applicants: Cardioxyl Pharmaceuticals, Inc., The Johns Hopkins UniversityInventors: John P. Toscano, Frederick Arthur Brookfield, Andrew D. Cohen, Stephen Martin Courtney, Lisa Marie Frost, Vincent Jacob Kalish
-
Use of a Composition Comprising an Antacid, a Mucolytic and a Gelling Agent in the Treatment of Cold
Publication number: 20140194515Abstract: The present invention is directed to a medicine to alleviate and cure colds by reducing acid content and stimulation of increased mucus production due to the fact that active components of the substance consist of acid stanching components like proton pumps stanches, histamine-2-receptor-antagonists, mucus stimulating components as acetylcysteine and alginic acid. This together creates an optimal healing environment in the respirator passages.Type: ApplicationFiled: January 13, 2014Publication date: July 10, 2014Inventor: Barbara Nelson -
Publication number: 20140194392Abstract: A drug screening method is disclosed. The drug screening method includes steps of screening a compound library to obtain a first group of compounds capable of binding to a wild type target; screening the first group of compounds to obtain a second group of compounds capable of binding to a mutant site of a mutant target; analyzing characteristics of binding sites of the wild type target and the mutant type target to obtain physico-chemical properties of the binding sites; identifying a candidate from the second group of compounds according to the physico-chemical properties of the binding site; and performing a bio-assay on inhibitory activity of the candidate.Type: ApplicationFiled: April 29, 2013Publication date: July 10, 2014Applicant: NATIONAL CHIAO TUNG UNIVERSITYInventors: Jinn-Moon Yang, Kai-Cheng Hsu
-
Publication number: 20140187631Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprises 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).Type: ApplicationFiled: February 3, 2012Publication date: July 3, 2014Inventors: Richard D. Kpoke, Robert A. Floyd, Rheal Towner
-
Publication number: 20140178358Abstract: The present invention concerns means and methods for predicting the risk of a subject to suffer from liver damage. In particular, it pertains to a method for predicting the risk of a subject to suffer from liver damage caused by acetaminophen comprising determining the amount of putrescine in a blood, serum or plasma sample that has been obtained from the subject after administration of acetaminophen, and comparing the determined amount to a reference, whereby the risk of the subject to suffer from liver damage caused by acetaminophen is predicted. Also provided are devices for carrying out the aforementioned methods.Type: ApplicationFiled: December 20, 2013Publication date: June 26, 2014Applicants: The United States of America as represented by the Secretary of Department of Health and Human Servi, Metanomics Health GmbHInventors: Alexander Strigun, Lisette Leonhardt, Dörthe Ahlbory-Dieker, Lisa M. Pence, Richard Beger
-
Patent number: 8759579Abstract: The invention encompasses a novel class of cyclobutyl sulfone derivatives which inhibit the processing of APP by the putative ?-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.Type: GrantFiled: April 17, 2009Date of Patent: June 24, 2014Assignee: Merck Sharp & Dohme Corp.Inventors: Richard W. Heidebrecht, Chaomin Li, Benito Munoz, Andrew Rosenau, Laura M. Surdi, Paul Tempest
-
Publication number: 20140171383Abstract: The present invention concerns compositions, methods and/or apparatus of central administration of various CNS-active agents. In particular embodiments, intrathecal administration is advantageous for decreasing the systemic concentrations of CNS agent, thereby decreasing side effect toxicity, while allowing more effective delivery of the agent to the site of action, simultaneously decreasing the dosage delivered to the subject. In particular embodiments, ICV delivery may be of use for patients who have previously proven to be refractory to systemic administration of CNS agents, in some cases due to systemic side effects, or for those patients whose symptoms are of sufficient severity to warrant more aggressive therapeutic intervention. ICV administration allows not only lower systemic concentration but also higher therapeutically effective concentration within the CNS.Type: ApplicationFiled: June 28, 2013Publication date: June 19, 2014Inventors: Daniel J. ABRAMS, Raymond Bunch, Tom Anchordoquy
-
Publication number: 20140163042Abstract: Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers, wherein R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non-natural alpha amino acid; Y is a bond, —C(?O), —S(?O)2—, —C(?O)O—, —C(O)NR3—, —C(?S)—NR3, —C(?NH)NR3 or —S(?O)2NR3— wherein R3 is hydrogen or optionally substituted C1-C6 alkyl; L1 is a divalent radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n and p are independently 0 or 1, Q is (i) an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members, or (ii), in the case where both m and p are 0, a divalent radical of formula —X2-Q1- or -Q1-X2— wherein X2 is —O—, S— or NRA— wherein RA is hydrogen or optionally substituted C1-C3 alkyl, and Q1 is an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic rType: ApplicationFiled: February 13, 2014Publication date: June 12, 2014Applicant: Chroma Therapeutics Ltd.Inventors: Alan Hornsby Davidson, Sanjay Ratilal Patel, Francesca Ann Mazzei, Stephen John Davies, Alan Hastings Drummond, David Festus Charles Moffat, Kenneth William John Baker, Alastair David Graham Donald
-
Publication number: 20140163104Abstract: The present invention relates to uses of and methods of treatment with cystathionine. In one embodiment, cystathionine reduces the development of toxin-induced liver and/or kidney disease induced by homocystinuria and/or acute nephropathy. In one embodiment, a cystathionine synthesis inhibitor is administered to increase tumor cell apoptosis and/or increase the efficacy of chemo therapeutic treatment. More particularly, cystathionine can protect cells against toxin-induced cellular apoptosis and/or cystathionine synthesis inhibitors can increase neuroblastoma cell kill rates during chemotherapy.Type: ApplicationFiled: June 1, 2012Publication date: June 12, 2014Inventors: Kenneth Maclean, Richard Austin
-
Publication number: 20140155355Abstract: The invention provides novel compounds of formulae I and II: that are monoamine oxidase-B inhibitors, which can be useful in treating obesity, diabetes, and/or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance).Type: ApplicationFiled: April 29, 2013Publication date: June 5, 2014Inventor: Jenrin Discovery
-
Publication number: 20140147448Abstract: The invention includes compositions and methods useful for treating preventing abnormal thrombus formation and subsequent cardiovascular disease in diabetic patients and patients with increased cardiovascular risk.Type: ApplicationFiled: June 5, 2012Publication date: May 29, 2014Applicant: Yale UniversityInventors: John Hwa, WaiHo Tang
-
Publication number: 20140141098Abstract: Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide or nitric oxide releasing compounds as a mucolytic agent or expectorant are provided. Delivery of gaseous nitric oxide can be made nasally or orally and is preferably substantially coincident with inhalation of the mammal or based on a synchronous parameter of the mammal's respiratory cycle. Varying therapeutic profiles may be used for the delivery of gaseous nitric oxide depending on the severity of the excess mucus accumulation. Parameters for the therapeutic profiles may include flow rate of nitric oxide containing gas, duration of administration of nitric oxide containing gas, number of breaths for which nitric oxide containing gas is to be administered, and concentrations of therapeutic NO delivered to the airways.Type: ApplicationFiled: August 26, 2013Publication date: May 22, 2014Applicant: Pulmonox Technologies CorporationInventors: Bruce R. Murray, Christopher C. Miller, Douglas R. Hole
-
Publication number: 20140135396Abstract: The invention is directed to the treatment of patients at risk for liver damage due to the overingestion of acetaminophen by administering agents that increase hepatic levels of nitric oxide.Type: ApplicationFiled: July 4, 2012Publication date: May 15, 2014Applicants: BETH ISRAEL DEACONESS MEDICAL CENTER, INC., THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Wolfram Goessling, Andrew Cox, Trista North
-
Publication number: 20140135300Abstract: The compound of formula (I) is a water-stable, long acting ?2-selective adrenoceptor agonist useful as a bronchodilator in the treatment of bronchoconstriction associated with reversible obstructive airways diseases and the like. Processes for making the compound of formula (I), as well as related intermediates, are disclosed.Type: ApplicationFiled: January 17, 2014Publication date: May 15, 2014Applicant: SUNOVION PHARMACEUTICALS INC.Inventors: Craig R. Abolin, H. Scott Wilkinson, Paul McGlynn, William K. McVicar
-
Patent number: 8722738Abstract: A pharmaceutical composition and method for providing a reduction in side effects for human patients in need of therapy comprising the administration of a pharmaceutical composition comprising acetylcysteine is disclosed.Type: GrantFiled: July 21, 2011Date of Patent: May 13, 2014Assignee: Cumberland Pharmaceuticals, Inc.Inventors: Leo Pavliv, Amy Rock
-
Publication number: 20140128470Abstract: This invention relates to novel acetylcysteine compositions in solution, comprising acetylcysteine and which are substantially free of metal chelating agents, such as EDTA. Further, this invention relates to methods of making and using the acetylcysteine compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time maintaining the stability of the pharmaceutical formulation. The compositions and methods of this invention are useful in the treatment of acetaminophen overdose, acute liver failure, various cancers, methacrylonitrile poisoning, reperfusion injury during cardio bypass surgery, and radiocontrast-induced nephropathy, and can also be used as a mucolytic agent.Type: ApplicationFiled: January 13, 2014Publication date: May 8, 2014Applicant: Cumberland Pharmaceuticals, Inc.Inventor: Leo Pavliv
-
Publication number: 20140128469Abstract: The present invention provides a compound of Formula I: as defined herein, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: May 8, 2012Publication date: May 8, 2014Applicant: CONCERT PHARMACEUTICALS INC.Inventor: Roger Tung
-
Publication number: 20140128336Abstract: The present invention concerns products, such as compositions or medical devices, comprising one or more compounds of the Formula I, containing one or more free sulphhydryl groups, where R1 is hydrogen or an acetyl group, and R2 is a sulphhydryl group or a C1-C5 straight chained or branched hydrocarbon chain, optionally containing one or more heteroatoms selected from O, N and S, further containing one or more free sulphhydryl groups, for use in connection with Helicobacter pylori infections or other related infections, either as such or as combinations with antibiotics, whereby the compound(s) and optionally, when present, the antibiotic(s), are mixed with one or more pharmaceutically acceptable carriers providing sustained local release in the stomach or elsewhere in the upper aerodigestive tract.Type: ApplicationFiled: April 18, 2012Publication date: May 8, 2014Applicant: BIOHIT OYJInventors: Matti Härkönen, Tuuli Marvola, Mikko Salaspuro, Osmo Suovaniemi