Abstract: An ophthalmic solution comprising a hydrogen peroxide source in an amount sufficient to result in between about 0.001% and about 0.01% by weight stabilized hydrogen peroxide in said formulation as a preservative, one or more ocularly-compatible hydrogen peroxide stabilizers, hydroxypropylmethylcellulose and sodium carboxymethylcellulose, as well as pharmaceutical compositions comprising such solutions, are provided.
Abstract: Formulations and methods for protecting cell layers and tissues exposed to trauma are disclosed. Different molecular mass fractions of the same polymer can be used to better control the physical and chemical properties of the formulation. In this manner the benefits of both fractions, and not just the benefits of the average of the fractions, can be seen in the formulation.
Type:
Application
Filed:
February 14, 2012
Publication date:
August 16, 2012
Inventors:
Rolf Bergman, Maria Lundqvist, Stig Mannberg, Björn Lundgren, Robert Shimizu
Abstract: The present disclosure relates to the cosmetic use of grafted polysaccharide compounds comprising at least one non-polymer siloxane graft that may be obtained by reacting a polysaccharide and a siloxane compound corresponding to formula (I), such as for the cosmetic treatment of keratin materials. The disclosure also relates to compositions comprising the grafted polysaccharide compounds in a cosmetically acceptable medium, and also to certain novel grafted polysaccharide compounds comprising at least one non-polymer siloxane graft.
Abstract: A method of and product for reducing the undesirable effects of allergic rhinitis by applying a formulation to a person's nasal region or nostrils. The formulation creates a barrier that prevents airborne allergens from contacting nasal mucous membranes, and at the same time, electrostatically repels or attracts and captures the particulate allergens, and changes their shapes so as to mitigate the effects of allergic rhinitis. The formulation may be made more effective by the addition of an anti-histamine compound.
Abstract: The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ?-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
Type:
Application
Filed:
January 11, 2012
Publication date:
July 26, 2012
Applicant:
ABBOTT LABORATORIES
Inventors:
Jeffrey H. Baxter, Anne C. Voss, Pradip Mukerji
Abstract: The invention provides body absorable, mechanically hemostatic putty compositions comprising carboxymethyl cellulose and one or more of polyhydroxy compounds, fatty acids, and esters thereof for use in controlling the bleeding of bone.
Abstract: A device including a body (12) including fibers without oxidized cellulose. The body (12) also includes fibers containing oxidized cellulose.
Type:
Application
Filed:
December 9, 2011
Publication date:
July 12, 2012
Applicant:
Perouse Medical
Inventors:
Vithuy Dao, Robert Michelot, Eric Perouse
Abstract: The inventors surprisingly found that specific oligosaccharides are capable of inhibiting viral replication through inhibiting NF-?B activation. The invention thus pertains to a composition comprising pectin (in the form of digalacturonic acid, trigalacturonic acid, polygalacturonic acid), Arabinoxylan from rice bran, ?-glucan from bakers yeast, D-Ribose or mixtures there-of for inhibiting viral replication in a mammal with a viral disease.
Type:
Application
Filed:
June 21, 2010
Publication date:
July 12, 2012
Inventors:
Klaske Van Norren, Francina Jeannette Dijk, Benjamin Berkhout, Belinda Van't Land Potappel
Abstract: A topical skin barrier for protecting and promoting healing of skin, and for providing comfort to a patient, comprises a semi-solid hydrocarbon, a water-absorbing compound, and a pain relief agent. The topical skin barrier effectively adheres to skin, affords protection from moisture and waste, provides transparency in use, and is anhydrous and therefore is preservative-free. Methods of in vitro evaluation are for (i) a composition's protection from moisture and waste, and (ii) a composition's adhesion to skin.
Abstract: The present invention generally concerns the detection and/or treatment of aneurysm in a non-invasive manner. In particular cases, the invention concerns methods and compositions for localizing a labeled composition to the site of an aneurysm for its detection and, in further cases, treatment of the aneurysm. In specific cases, the composition targets a subendothelial component of the aneurysmal wall, such as a smooth muscle cell exposed at the luminal surface of the vessel. In further specific cases, the composition targets an integrin receptor or laminin.
Type:
Application
Filed:
November 23, 2008
Publication date:
June 28, 2012
Inventors:
Lionel C. Sevrain, Sylvie Y. Verdier- Sevrain
Abstract: An appetite suppressant composition that is effective for the control of mammalian weight and methods of administration of the composition of the invention are provided. The composition is a cellulose product prepared with ethanol preferably with added sweetener, spice(s), salt and protein for oral administration to a patient.
Abstract: A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized polysaccharide containing pendant aldehyde groups with a water-dispersible, multi-arm amine is described. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a more rapid degradation time, such as the prevention of undesired tissue-to tissue adhesions resulting from trauma or surgery.
Abstract: A thermally modified microbial-derived cellulose material is described for use as an implantable material in general surgery, plastic surgery and neurosurgery.
Type:
Grant
Filed:
August 18, 2004
Date of Patent:
June 12, 2012
Assignee:
Xylos Corporation
Inventors:
Christopher James Damien, Gerry Ann Oster, Heather Ann Beam
Abstract: The invention relates to a method for smoothing out the skin by filling in recessed portions of the skin, said method comprising filling the recessed portions by means of a filling-in product which has an elastic modulus of greater than 20 000 Pascals at 25° C. for a stress frequency of 1 Hertz, a flow point of greater than 500 Pascals, and, for applied stresses of less than the yield stress, a viscosity of greater than 100000 Pa.s, the product being such that, once applied in said recessed portions of the skin, its mechanical properties change subsequent to a reaction other than an evaporation reaction or a laser polymerization re action.
Type:
Application
Filed:
June 29, 2010
Publication date:
May 31, 2012
Applicant:
L'Oreal
Inventors:
Guillaume Cassin, Henri Samain, Jean-Thierry Simonnet
Abstract: The present invention relates to a composite material based on (a) a cellulose- or lignocellulose-containing material and (b) a composite as a binder, the composite resulting from the reaction of at least the components (i) a glycidyloxypropylalkoxysilane, (ii) an aqueous silica sol having a solids content of >20% by weight, (iii) an organic acid as a hydrolysis catalyst and (iv) n-propyl zirconate, butyl titanate or titanium acetylacetonate as a crosslinking agent. The present invention furthermore relates to a process for the production of said composite materials and the use of a composite (b) as a binder for the production of wood-based materials.
Type:
Grant
Filed:
June 14, 2006
Date of Patent:
May 29, 2012
Assignee:
Evonik Degussa GmbH
Inventors:
Roland Edelmann, Burkhard Standke, Peter Jenkner, Alireza Kharazipour, Lars Kloeser, Jaroslaw Monkiewicz
Abstract: The use of at least one carbonate of natural origin as a plasticizer in a film-forming cosmetic composition comprising, in a physiologically acceptable medium, a film-forming polymer and a solvent medium.
Type:
Grant
Filed:
January 10, 2007
Date of Patent:
May 29, 2012
Assignee:
Durlin France
Inventors:
Matthieu Bandres, Alain Deswartvaegher, Pascale De Caro, Jean-Pierre Senet, Sophie Thiebaud Roux
Abstract: A formulation has been developed for treatment of the symptoms of dry eye which incorporates the natural product jojoba wax, or components thereof, to enhance the spreading of the artificial tear and eyedrop as well as stabilize the eyedrop. The improved performance of the jojoba wax supplemented tear relieves irritation and discomfort as well as sharpens the blurred vision.
Abstract: The present invention pertains generally to the field of ocular treatment, and more specifically to the use of a liquid cooling agent composition comprising a cooling agent for the treatment of (e.g., the alleviation of symptoms of; the amelioration of) eye discomfort. The preferred cooling agent is (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarboxylic acid 2,3-dihydroxy-propyl ester (referred to herein as CPS-030). The liquid cooling agent composition is topically administered to at least a portion of the external surface of the eyelid (preferably the closed eyelid) of the eye to be treated. Preferably, the liquid cooling agent composition is carried on or in a wipe, pad, or towelette, for example, an eye wipe.
Abstract: Provided are food products comprising at least 0.5 g of trans fatty acid per serving and one or more water-insoluble cellulose derivatives in an amount sufficient to reduce absorption of the trans fatty acid by a mammal consuming the food product, methods of ameliorating the harmful effects of trans fatty acids on a mammal that has consumed trans fatty acids, and methods of reducing the amount of trans fatty acids capable of being absorbed by a mammal ingesting a trans fatty acid containing food product.
Type:
Application
Filed:
October 16, 2009
Publication date:
May 24, 2012
Inventors:
Kerr W.H. Anderson, David R. Albers, Scott A. Young, Wallace H. Yokoyama
Abstract: A stable and taste masked pharmaceutical dosage form includes porous apatite grains and a drug entrapped in pores of said grains, wherein said grains have a size of 0.1-1000 ?m and said pores of said grains have an opening of 0.5-300 nm. A process for preparing the stable and taste masked pharmaceutical dosage form is also disclosed.
Type:
Grant
Filed:
March 16, 2004
Date of Patent:
May 22, 2012
Assignee:
Nanotrend Ino-Tech Inc.
Inventors:
Chang-Yi Lin, Yunn-Tzer Lu, Dean-Mo Liu
Abstract: The present invention is related to the composition and methods of manufacture of orally-dissolvable, edible films as a vehicle for the non-invasive administration of nitroglycerin, as well as other therapeutic agents either with or without nitroglycerin, through the mucosal tissues of the oral cavity. The films include a water soluble film-forming polymer such as pullulan. Methods for producing the films are also disclosed.
Abstract: A hydrogel composition and a method for protecting a surface from thermal injury is disclosed. The method comprises applying a hydrogel composition to the surface to protect the skin from exposure to a heat flux, wherein the hydrogel is of a type and applied in an amount effective to reduce heat flux by at least 40 percent when exposed to a heat flux of 40 kW/m2. Representative examples of such hydrogels include ionized carboxymethyl cellulose hydrogel, ionized polyacrylate hydrogel, and a polymer formed from acrylic acid and crosslinked with polyalkenyl ethers or divinyl glycol.
Abstract: Disclosed are composites that comprise regenerated cellulose, a first active substance, a second active substance, and a linker. Methods for preparing the composites that involve the use of ionic liquids are also disclosed. Articles prepared from the disclosed composites and methods of using them are further disclosed.
Type:
Application
Filed:
June 5, 2007
Publication date:
May 17, 2012
Inventors:
Daniel T. Daly, Scott K. Spear, Megan B. Turner, Whitney Lauren Hough, Robin D. Rogers
Abstract: The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
Type:
Application
Filed:
January 11, 2012
Publication date:
May 17, 2012
Inventors:
Erning Xia, Joseph C. Salamone, X. Michael Liu
Abstract: A method for treating a site within a patient from which tissue has been removed includes providing at least one press-formed marker body formed of polysaccharide and a suitable binder; and placing the at least one of the press-formed marker body within the site where tissue has been removed so as to provide hemostasis therein.
Abstract: The present disclosure is directed to method of preparing an antimicrobial agent comprising heating a dialdehyde polysaccharide. The method comprises subjecting a dialdehyde polysaccharide, such as a dialdehyde starch or a dialdehyde cellulose, to heating and/or sonication for a period of time. Also provided herein is an antimicrobial composition comprising the prepared dialdehyde polysaccharide. The antimicrobial composition is effective at killing microbial agents such as viruses and bacteria within a short period of time.
Type:
Application
Filed:
November 8, 2010
Publication date:
May 10, 2012
Applicant:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
Inventors:
Ronald Howard Baney, Samuel Ralph Farrah, Le Song
Abstract: The composition and method for healing tissues is a medicinal composition for facilitating the growth, protection and healing of tissues and cells in animals and humans. The composition is formulated as a either a powder, gel, paste, film, fluid injectable, rehydratable freeze-dried paste or sponge, sprayable solution, topically applied patch with adhesive and reservoir system, an intermediate for coatables such as films and bandages, a matrix for membranes, or as a matrix of flexible polymer(s), or delivered as either an orally ingestible liquid, tablet or capsule. The main ingredient of the formulated compositions is hydrolyzed collagen, which can be combined with polysulfated glycosaminoglycans, hyaluronic acid or salts thereof, or a glucosamine salt, and mixtures thereof. The composition may be formulated as an aqueous eye drop solution.
Abstract: A personal care composition in the form of an aqueous gel may comprise an alpha-hydroxy acid, wherein the pH of the composition is less than about 4.5. The personal care composition comprises a gelling agent and an aqueous solvent. The personal care composition further comprises particulates and an effective amount of suspension agent to suspend the particulates. The personal care composition exhibits a consumer desired viscosity and translucency.
Type:
Grant
Filed:
October 28, 2009
Date of Patent:
April 24, 2012
Assignee:
The Procter & Gamble Company
Inventors:
Susan Adair Griffiths-Brophy, Dennis Eugene Kuhlman
Abstract: The present invention relates to a process for the production of suspensions of nano-fibrillar cellulose by providing cellulose fibres and at least one filler and/or pigment; combining the cellulose fibres and the at least one filler and/or pigment; and fibrillating the cellulose fibres in the presence of at least one filler and/or pigment, as well as the suspensions of nano-fibrillar cellulose obtained by this process and their uses.
Type:
Application
Filed:
March 30, 2010
Publication date:
April 19, 2012
Applicant:
Omya Development AG
Inventors:
Patrick A.C. Gane, Joachim Schoelkopf, Daniel Gantenbein, Michel Schenker, Michael Pohl, Beat Kübler
Abstract: A bioactive composition includes a porous hydrogel matrix. At least one protein is immobilized in the porous hydrogel matrix forming a hydrogel protein composite that is stable in an organic solvent. A process for stabilizing a bioactive composition includes the steps of: forming hydrogel matrix pores around protein molecules and reducing a water content within the hydrogel matrix pores forming a hydrogel protein composite that is stable in an organic solvent.
Type:
Application
Filed:
October 13, 2010
Publication date:
April 19, 2012
Applicant:
Toyota Motor Engineering & Manufacturing North America, Inc.
Abstract: Provided herein are methods of treating, suppressing, inhibiting, or preventing allergic rhinitis in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof.
Abstract: The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
Type:
Application
Filed:
July 15, 2011
Publication date:
March 22, 2012
Applicant:
Corinthian Ophthalmic, Inc.
Inventors:
Bernard L. Ballou, JR., Mark Packer, Russell John Mumper, Tsontcho Inachulev
Abstract: A composition for promoting wound healing comprises a bioadhesive polymer and a pharmaceutically acceptable liquid medium. Such a composition is applied to a wound to promote healing of the wound. The bioadhesive polymer can be selected from the group consisting of natural or synthetic hydrophilic polymers and hydrogels.
Type:
Application
Filed:
August 25, 2011
Publication date:
March 22, 2012
Inventors:
Jinzhong Zhang, Keith W. Ward, Francisco J. Lopez, Matthew Jonasse
Abstract: A delivery system for use in the oral cavity, the system comprising a carrier for a bioactive substance. The carrier has a surface comprising oxygen-binding sites (X), and at least one link comprising a pentose group and one or more additional sugar groups, the pentose group being bonded to one of said oxygen binding sites (X) and wherein one or more bioactive molecules (R) are bonded directly to one of the sugar groups of the at least one link or to one or more substituents on one or more sugar groups in the at least one link.
Abstract: An allergen inactivating agent is provided which has no adverse effects on the human body and which does not cause problems such as color development.
Abstract: A method for reversing gelation of hydrophobically modified biopolymer attached to vesicle or cell membranes. The gelation of hydrophobically modified biopolymer attached to vesicles or cell membranes is reversed by application of a supramolecule, such as cyclodextrin, to the gelled composition. The supramolecule disrupts the interactions between the hydrophobically modified biopolymer and the vesicle or cell membrane, without affecting the structure of the membrane or the hydrophobically modified polymer to which the hydrophobic substituents are attached. A kit for treating wounds that includes a hydrophobically modified biopolymer and a supramolecule. The hydrophobically modified biopolymer is used to stop bleeding and the supramolecule is used to remove the hydrophobically modified biopolymer.
Type:
Application
Filed:
August 13, 2011
Publication date:
March 8, 2012
Inventors:
Matthew Dowling, Srinivasa R. Raghavan, Rakesh Kumar
Abstract: Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual.
Type:
Application
Filed:
June 17, 2011
Publication date:
March 8, 2012
Inventors:
William A. GODDARD, III, Mark MENNA, Stephen PANDOL, Ravinder ABROL
Abstract: A composition for reducing pain at a surgical wound site or trauma site comprising oxidized regenerated cellulose and a non-steroidal anti-inflammatory drug or pharmaceutically acceptable salt or ester thereof, where the non-steroidal anti-inflammatory drug is an acid having a secondary amine group; and a method of reducing localized pain at a surgical wound site or trauma site.
Type:
Grant
Filed:
June 4, 2004
Date of Patent:
March 6, 2012
Assignee:
Ethicon, Inc.
Inventors:
Uri Herzberg, Robert A. Rousseau, J. Jenny Yuan, Dwayne Looney, Hock S Tan
Abstract: Low density cosmetic formulations which comprise: (a) a cosmetic mixture; and (b) a gas incorporated in the cosmetic mixture; wherein the cosmetic mixture comprises (i) an alk(en)ylpolyglycoside, (ii) a quaternary ammonium polymer, and (iii) a thickener, are described along with suitable cosmetic mixtures for forming such low density formulations, methods of forming such formulations and methods of treating skin, hair, nails and/or combinations thereof by contacting the skin, hair and/or nails with such formulations and/or products containing such formulations.
Abstract: A hydrogel tissue adhesive having decreased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm polyether amine in the presence of an oligomer additive, which promotes the degradation of the hydrogel. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, such as a hemostat sealant or to prevent undesired tissue-to-tissue adhesions resulting from trauma or surgery.
Abstract: A method for bonding a polymeric fiber to tissue is provided which includes providing a polymeric fiber having a plurality of tissue reactive members linked to a surface of the fiber via a specific binding pair, and contacting the polymeric fiber to biological tissue, to covalently bond the fiber to the tissue.
Abstract: The present invention relates to mechanically hemostatic body-absorbable compositions having a putty-like consistency comprising a finely powdered polysaccharide and a biocompatible liquid comprising one or more block copolymers of ethylene oxide and propylene oxide.
Abstract: The present invention relates to Fc-OB fusion protein compositions, methods of preparation of such compositions and uses thereof. In particular, the present invention relates to a genetic or chemical fusion protein comprising the Fc immunoglobulin region, derivative or analog fused to the N-terminal portion of the OB protein, derivative or analog.
Type:
Grant
Filed:
September 22, 2006
Date of Patent:
December 20, 2011
Assignee:
Amgen, Inc.
Inventors:
Michael B. Mann, Randy Ira Hecht, Mary Ann Pellymounter, Christopher Francis Toombs
Abstract: The present invention provides a method for using processed-cellulose. Preferably, the processed cellulose is a highly refined cellulose (HRC). The HRC is useful in a number of medical and nutritional applications. These medical and nutritional applications can include, but are not limited to, administering effective amounts of the HRC for lowering values of risk factor measurements for such diseases as arteriosclerotic cardiovascular disease and diabetes. Treatment of other diseases and conditions with the HRC is also possible.
Type:
Application
Filed:
August 24, 2011
Publication date:
December 15, 2011
Applicant:
Regents of the University of Minnesota
Inventors:
PAUL BRADLEY ADDIS, Rongsheng Roger Ruan, Joseph M. Keenan, Daniela Geleva
Abstract: This invention provides a method of preventing asthma, allergic rhinitis, or chronic obstructive pulmonary disease in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof. This invention also provides a method of treating allergic rhinitis or chronic obstructive pulmonary disease in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof.
Type:
Grant
Filed:
November 23, 2005
Date of Patent:
December 13, 2011
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
Abstract: A nerve dysfunction repairing material including a hydrogel of a polysaccharide derivative that has, in a 0.5 wt % aqueous solution, a complex modulus of 1 to 1000 N/m2 and a loss factor of 0.01 to 2.0 as measured at an angular velocity of 10 rad/sec using a dynamic viscoelasticity measuring apparatus. The nerve dysfunction repairing material can be a hydrogel injectable through a syringe, has excellent retention in the body, and has a restorative effect on the function of damaged or degenerated nerves.
Type:
Application
Filed:
September 18, 2009
Publication date:
December 8, 2011
Applicants:
UNIVERSITY NAGOYA NATIONAL UNIVERSITY CORPORATION, TEIJIN LIMITED
Abstract: A pharmaceutical combination or composition containing a lipase inhibitor, preferably orlistat, and a bile acid sequestrant is useful for treating obesity.
Type:
Grant
Filed:
April 20, 2010
Date of Patent:
December 6, 2011
Assignee:
Hoffman-La Roche Inc.
Inventors:
Pierre Barbier, Paul Hadvary, Hans Lengsfeld