Carbon To Carbon Unsaturation In R Patents (Class 514/627)
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Publication number: 20140255322Abstract: A siloxane polymer base that is useful as an excipient for many variable materials that can be compounded into it. Also disclosed are a method for the preparation of such bases, and another method regarding the preparation of the base and actives.Type: ApplicationFiled: May 23, 2014Publication date: September 11, 2014Inventors: John D. Blizzard, Robert L. McKellar
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Publication number: 20140234412Abstract: Suggested are new compositions for oral ingestion, comprising at least one active agent from the group of alkamides. The compositions which are orally ingested reduce the uptake of free fatty acids in the adipocytes and at the same time stimulate the release of serotonin and dopamine, which leads to a reduction of appetite, a feeling of satiety and a positive mood. In doing so, the new compositions are thus perfectly suitable to counteract any undesired gain of weight.Type: ApplicationFiled: February 12, 2014Publication date: August 21, 2014Applicant: Symrise AGInventors: Jakob Ley, Sabine Widder, Veronika Somoza, Barbara Rohm, Matthias Zaunschirm, Gerhard Krammer
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Patent number: 8809395Abstract: The present invention is directed to compounds, intermediates and methods for making valerenic acid and its derivatives as well as the use of such compounds as GABAA receptor ligands.Type: GrantFiled: January 22, 2010Date of Patent: August 19, 2014Assignee: Valericon GmbHInventors: Johann Mulzer, Jürgen Ramharter, Steffen Hering, Sophia Khom
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Publication number: 20140227200Abstract: The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E,6E,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E,6Z,8Z)—N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided.Type: ApplicationFiled: April 21, 2014Publication date: August 14, 2014Applicant: Takasago International CorporationInventors: Louis Lombardo, Michael E. Lankin, Kenya Ishida, Shigeru Tanaka, Hideo Ujihara, Kenji Yagi, Jennifer B. Tartaglia, Carter B. Green, Amrit S. Mankoo
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Publication number: 20140228442Abstract: Grease-like compositions are provided for repelling rodents. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.Type: ApplicationFiled: April 18, 2014Publication date: August 14, 2014Applicant: Pacific Tech Industries, Inc.Inventors: Richard Numata, Ryan Willey
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Patent number: 8802735Abstract: The invention relates to solid pharmaceutical compositions comprising (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4?-trifluoromethylphenyl)-amide, as well as a process for the preparation of the same, methods of using such compositions to treat subjects suffering from autoimmune diseases in particular systemic lupus erythematosus or chronic graft-versus-host disease, multiple sclerosis or rheumatoid arthritis.Type: GrantFiled: March 16, 2012Date of Patent: August 12, 2014Assignee: SanofiInventor: Gerrit Hauck
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Patent number: 8802736Abstract: The present invention relates to a composition useful for pain relief. The composition is high concentration capsaicinoid topical composition comprising an analgesic agent that eliminates or reduces the burning or stinging sensation or erythema of the capsaicinoid.Type: GrantFiled: March 12, 2013Date of Patent: August 12, 2014Assignee: API Genesis, LLCInventors: Daniel Bucks, Philip J. Birbara
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Publication number: 20140205688Abstract: The present invention relates to a stimulating agent comprising a pungent component having astringency, a stimulating composition including the agent, as well as a flavor or fragrance composition, a food, a drink, an oral care product and an external skin preparation containing the agent or the composition, and also relates to the use of a pungent component having astringency as a stimulating agent. Examples of the pungent component having astringency include a plant extract of Asteraceae Spilanthes, Rutaceae Zanthoxyium, Rutaceae Fagara, or Piperaceae Piper, or an amide derivative represented by general formula (1) (where R1 represents an alkenyl group having 2 to 12 carbon atoms which may be substituted by a methylenedioxyphenyl at the end, R2 and R3 may be the same or different from each other and each are a hydrogen atom or a lower alkyl group in which a hydroxyl group may be substituted, and R2 and R3, together with the nitrogen atom adjacent thereto, may form a heterocyclic ring).Type: ApplicationFiled: May 29, 2012Publication date: July 24, 2014Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Kaori Takahashi, Miyuki Takayanagi
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Publication number: 20140199267Abstract: The invention provides methods for using fatty acid alkanolamides for ameliorating one or more symptoms or conditions caused by stress, e.g., loss of appetite, or for maintaining and enhancing nutrient and caloric intake by an animal under stress or that has experienced stress. Generally, the fatty acid alkanolamides in amounts of from about 0.1 to about 1500 mg/kg/day before, during or after stress, preferably on a regular or daily basis as a component of a food composition or as a dietary supplement.Type: ApplicationFiled: August 7, 2012Publication date: July 17, 2014Applicant: Nestec SAInventors: Delphine Tissot-Favre, Yuanlong Pan
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Publication number: 20140200531Abstract: Aspects of the present invention concern the discovery of a transdermal delivery composition that can deliver low, medium and high molecular weight pharmaceuticals and cosmetic agents. Embodiments include transdermal delivery compositions with therapeutic and cosmetic application, transdermal delivery devices for providing said transdermal delivery compositions to subjects in need thereof, and methods of making and using of the foregoing.Type: ApplicationFiled: December 19, 2013Publication date: July 17, 2014Applicant: JRX Biotechnology, Inc.Inventors: Frederick Jordan, Geoff E. Dolbear
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Publication number: 20140193346Abstract: Herbal composition and method for the treatment of inflammatory pain associated with tendonitis, bursitis, arthritis, carpal tunnel syndrome, tennis elbow, plantar fasciitis, sports injuries, lower back pain and overexertion, gingivitis and muscle aches, that is compliant with HPUS monographs and/or over-the-counter FDA topical analgesic monograph requirements.Type: ApplicationFiled: January 7, 2013Publication date: July 10, 2014Applicant: DRT LABORATORIES LLCInventor: Ronit Arginteanu
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Publication number: 20140193349Abstract: The invention relates to the nontherapeutic cosmetic use of at least one cannabinoid compound chosen from the compounds corresponding to general formula (I): and also the geometric isomers and optical isomers thereof, the cosmetically acceptable acid or base salts thereof, and the hydrates thereof; in which compounds of formula (I): R1 represents a hydrogen atom or a C1-C30 alkyl group; it being possible for said alkyl group to be optionally substituted with a hydroxyl (OH) group; R2 represents a halogen atom or a group chosen from hydroxyl, thiol (SH), and amino optionally substituted with one or two C1-C6 alkyl groups; R3 and R4 form, together with the carbon atom which bears them, an oxo group or else R3 and R4 represent a hydrogen atom; R5 represents a hydrogen atom or a C1-C6 alkyl group; X represents a heteroatom chosen from oxygen and sulfur atoms and the divalent group —N(R6)—, with R6 representing a hydrogen atom or a C1-C6 alkyl group; represents a single or double bond; n is 1, 2 or 3, prefeType: ApplicationFiled: August 3, 2012Publication date: July 10, 2014Applicant: L'OREALInventors: Michela Zuccolo, Roland Jourdain, Lionel Breton, Mauro Maccarrone
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Publication number: 20140193370Abstract: The invention provides methods for promoting lean body mass growth in an animal. The methods comprise administering OEA to the animals, preferably in amounts of from about 0.01 to about 1000 mg/kg/day.Type: ApplicationFiled: May 8, 2012Publication date: July 10, 2014Applicant: NESTEC SAInventors: Delphine Tissot-Favre, Yuanlong Pan, George Wells
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Publication number: 20140187619Abstract: Methods of treatment in subjects suffering from diabetes mellitus or obesity are provided. The methods comprise the step of administering an active agent directly to the small intestine in the subject. In particular, the active agent may be administered directly to the duodenum in the subject. The active agents useful in the treatments described herein include analgesic agents and, in particular, antinociceptive agents such as capsaicin, resiniferatoxin, and their analogues.Type: ApplicationFiled: July 18, 2012Publication date: July 3, 2014Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Pankaj Jay Pasricha, Liansheng Liu
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Publication number: 20140171511Abstract: The present invention relates to a product comprising capsaicin or a capsaicinoid for use in the treatment of cough, in particular chronic persistent unexplained cough or increased cough reflex sensitivity. More precisely, the invention concerns oral formulations for reducing and relieving coughing from other irritants than capsaicin itself. The capsaicin formulations are stated to down-regulate coughing following a regular consumption. Said products can also be used in the treatment of rhinitis and other conditions known to have cough symptoms.Type: ApplicationFiled: July 4, 2012Publication date: June 19, 2014Inventor: Eva Millqvist
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Publication number: 20140161763Abstract: The methods, kits, and products for controlling a target insect population are disclosed in which a non-host plant containing a toxin and a chemical attractant known to attract the target insect is treated with chemical attractant from a plant of interest. The chemical attractant induces the target insect to lay eggs on the non-host plant. The resulting offspring die of starvation from refusing to feed on the non-host plant. The non-host plant and plant of interest contain at least one common chemical. The methods, kits, and products for controlling a target insect population using an extract from a non-host plant are also disclosed. The non-host plant extract is applied to the plant of interest, and when ingested or applied directly to the target insect, kills the target insect or causes it to develop with deformities.Type: ApplicationFiled: January 28, 2011Publication date: June 12, 2014Applicant: University of the West Indies, a Regional Institution, established by Royal CharterInventors: Trevor Herbert Yee, Charah Tabetha Watson, Eric Garraway, Dwight Robinson, Nemoi Nastassia Sri Garcia Chisholm
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Publication number: 20140161868Abstract: A transdermal delivery kit that enhances the efficacy of a topical drug includes at least one drug dispensing device, a lipophilic base, a hydrophilic base, a lipid-soluble active ingredient, a water-soluble active ingredient, a first container for mixing the lipophilic base with the lipid-soluble active ingredient to form a first compound, a second container for mixing the hydrophilic base with the water-soluble active ingredient to form a second compound, a mixing member, and instructions for compounding the lipophilic base with the lipid-soluble active ingredient to form the first compound, compounding the hydrophilic base with the water-soluble active ingredient to form the second compound, and mixing the first compound and the second compound to form a transdermal pharmaceutical delivery system capable of delivering a drug to the dermal layer of the skin.Type: ApplicationFiled: February 12, 2014Publication date: June 12, 2014Applicant: GENSCO LABORATORIES LLCInventors: Carlos A. Alfaras, Paul M. Zimmerman, Urbano Zamora
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Publication number: 20140163112Abstract: Grease-like compositions are provided for repelling insects and preventing undesirable behavior in hoofed animals. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.Type: ApplicationFiled: February 18, 2014Publication date: June 12, 2014Applicant: Pacific Tech Industries, Inc.Inventors: Richard Numata, Ryan Willey
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Publication number: 20140155426Abstract: Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse; and an effective amount of an irritant to impart an irritating sensation to an abuser upon administration of said dosage form after tampering.Type: ApplicationFiled: January 7, 2014Publication date: June 5, 2014Applicant: Purdue Pharma L.P.Inventor: Richard Sackler
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Patent number: 8741958Abstract: The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E,6E,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E,6Z,8Z)-N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided.Type: GrantFiled: July 17, 2009Date of Patent: June 3, 2014Assignee: Takasago International CorporationInventors: Louis Lombardo, Michael E. Lankin, Kenya Ishida, Shigeru Tanaka, Hideo Ujihara, Kenji Yagi, Jennifer B. Mei, Carter B. Green, Amrit S. Mankoo
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Publication number: 20140147481Abstract: The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.Type: ApplicationFiled: June 3, 2011Publication date: May 29, 2014Applicants: UNIVERSITY OF RHODE ISLAND RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: William Gerwick, Lena Gerwick, Huykjae Choi, Francisco Villa, Jennifer Smith, David C Rowley
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Patent number: 8735427Abstract: Grease-like compositions are provided for repelling rodents. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.Type: GrantFiled: April 7, 2011Date of Patent: May 27, 2014Assignee: Pacific Tech Industries, Inc.Inventors: Richard Numata, Ryan Willey
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Publication number: 20140142073Abstract: Capsaicinoid formulations and methods of treatment are disclosed herein which can be utilized to treat/attenuate pain in mammals. Typically, administration is via injection at a discrete site to provide pain relief for an extended period of time. The formulations are administered in a pharmaceutically acceptable vehicle. The formulations include an analgesic agent in an amount sufficient to attenuate the burning and hyperalgesic effects of capsaicinoid administration. The invention also includes a method of treating pain by administering a corticosteroid followed by administration of a capsaicinoid.Type: ApplicationFiled: November 12, 2013Publication date: May 22, 2014Applicant: API Genesis, LLCInventors: Charles A. Birbara, Philip J. Birbara, Daniel Bucks, Mary Coughlin
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Publication number: 20140134135Abstract: The invention provides compositions and methods for preserving lean body mass during weight loss in an animal. The methods comprise administering OEA to the animals, preferably in amounts of from about 0.01 to about 1000 mg/kg/day.Type: ApplicationFiled: May 8, 2012Publication date: May 15, 2014Applicant: NESTEC SAInventors: Delphine Tissot-Favre, Yuanlong Pan
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Publication number: 20140128335Abstract: The present invention relates to the use of polyaminoisoprenyl derivatives in antibiotic or antiseptic treatment of bacteria including those presenting multiple drug resistance (MDR), in particular as efflux pump inhibitors. It also relates to novel polyaminoisoprenyl derivatives, compositions comprising the same, process for preparing the same, and use thereof in antibiotic or antiseptic treatment.Type: ApplicationFiled: February 23, 2012Publication date: May 8, 2014Applicants: UNIVERSITE D'AIX-MARSEILLE, UNIVERSITE DE CORSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Jean-Michel Bolla, Jean Michel Brunel, Joseph Pierre Felix Casanova, Vannina Lorenzi, Liliane Berti
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Patent number: 8703824Abstract: The present invention discloses novel cationic amphiphiles containing mannose-mimicking shikimic and quinic acid head-groups and a process for preparing cationic amphiphiles with mannose-mimicking polar head-groups such as, shikimic and quinic acids. The findings described herein also demonstrate that compounds of the present invention can target model DNA vaccines to antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs), via mannose receptors expressed on the cell surface of APCs. The cationic amphiphiles disclosed herein show enhanced cellular and humoral immune response compared to their mannosyl counterpart in dendritic cell (DC, the most professional APC) based genetic immunization in mice. Cationic amphiphiles with mannose-mimicking quinic and shikimic acid head-groups described in the present invention are likely to find future applications in the field of genetic immunization.Type: GrantFiled: September 14, 2011Date of Patent: April 22, 2014Assignee: Council of Scientific & Industrial ResearchInventors: Ramishetti Srinivas, Arup Garu, Sachin B. Agawane, Arabinda Chaudhuri
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Patent number: 8697752Abstract: Grease-like compositions are provided for repelling insects and preventing undesirable behavior in hoofed animals. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.Type: GrantFiled: April 4, 2012Date of Patent: April 15, 2014Assignee: Pacific Tech Industries, Inc.Inventors: Richard Numata, Ryan Willey
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Publication number: 20140094521Abstract: The objective of the present invention is to provide a new compound which is effective in treating blood cancer, particularly multiple myeloma, and which is also effective in suppressing an SP cell, i.e. Side Population Cell, which is a cause of recurrence of cancer. The compound according to the present invention is a novel compound which has the specific benzylamine structure.Type: ApplicationFiled: May 23, 2012Publication date: April 3, 2014Applicant: THE UNIVERSITY OF TOKUSHIMAInventors: Daisuke Tsuji, Kohji Itoh, Akira Otaka, Akira Shigenaga, Masahiro Abe, Masahiro Hiasa
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Publication number: 20140086857Abstract: Compositions comprising siloxane polymers are disclosed. The compositions are useful as thixotropic bases for a variety of components, such as antimicrobial agents, sterilants, medicaments, antibiotics, analgesics, essential oils, preservatives, colorants, fragrances, and the like. Methods for preparing the compositions are also disclosed.Type: ApplicationFiled: May 10, 2012Publication date: March 27, 2014Applicant: QUADSIL, INC.Inventor: John D. Blizzard
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Publication number: 20140088196Abstract: System, including methods compositions, and kits, for controlling the growth of fungi and other pathogens in plants using at least one alkamide, which may function by increasing or eliciting natural defense mechanisms of the plants against such pathogens.Type: ApplicationFiled: September 16, 2013Publication date: March 27, 2014Applicant: Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional (CINVESTAV)Inventors: José López-Bucio, Jorge Molina-Torres, Luis Rafael Herrera-Estrella
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Patent number: 8680153Abstract: The present invention relates to methods for the treatment of a disease or condition associated with lipid imbalance, comprising (a) decreasing arachidonic acid (AA) levels, (b) increasing docosahexaenoic acid (DHA) levels, (c) increasing DHA/AA ratio or (d) any combination of (a)-(c) in a subject using fenretinide. The invention also relates to diagnostic and screening methods based on the determination of lipid levels.Type: GrantFiled: December 13, 2006Date of Patent: March 25, 2014Assignee: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Danuta Radzioch, Claudine Guilbault, Juan Bautista De Sanctis
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Publication number: 20140080914Abstract: There is provided an aqueous acrylamide solution including 2,2,6,6-tetramethylpiperidine 1-oxyl in the ratio of 2 to 100 mg and manganese ions in the ratio of 0.2 to 2.0 mg per 1 kg of acrylamide. According to the present invention, an aqueous acrylamide solution having favorable quality and high stability with suppressed polymerization of acrylamide, a stabilizer used therefore, and a stabilization method can be provided.Type: ApplicationFiled: May 21, 2012Publication date: March 20, 2014Applicant: Mitsubuishi Rayon Co., Ltd.Inventors: Makoto Kanou, Norifumi Hagiya
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Patent number: 8673982Abstract: This invention relates to certain ceramide-analogues of FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol; fingolimod). In particular, the present invention relates to pharmaceutical compositions comprising these compounds, as well as processes for their preparation and their use in the treatment of autoimmune conditions, such as multiple sclerosis.Type: GrantFiled: February 23, 2010Date of Patent: March 18, 2014Assignee: Novartis AGInventors: Volker Brinkmann, Guido Jordine, Markus Zollinger, Claudia Sayer
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Publication number: 20140073612Abstract: A transdermal delivery kit that enhances the efficacy of a topical drug includes at least one drug dispensing device, a lipophilic base, a hydrophilic base, a lipid-soluble active ingredient, a water-soluble active ingredient, a first container for mixing the lipophilic base with the lipid-soluble active ingredient to form a first compound, a second container for mixing the hydrophilic base with the water-soluble active ingredient to form a second compound, a mixing member, and instructions for compounding the lipophilic base with the lipid-soluble active ingredient to form the first compound, compounding the hydrophilic base with the water-soluble active ingredient to form the second compound, and mixing the first compound and the second compound to form a transdermal pharmaceutical delivery system capable of delivering a drug to the dermal layer of the skin.Type: ApplicationFiled: September 11, 2012Publication date: March 13, 2014Inventors: Carlos A. Alfaras, Paul M. Zimmerman, Urbano Zamora
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Publication number: 20140056990Abstract: Provided herein formulations of capsaicin for delivery by nasal route and methods of using the formulations for the treatment of migraines and other severe headaches. The formulations described herein contain mucoadhesives to optimize the therapeutic effect of capsaicin by intranasal delivery.Type: ApplicationFiled: August 23, 2013Publication date: February 27, 2014Applicant: VR1, INC.Inventor: Anjan Chatterjee
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Publication number: 20140051751Abstract: Environmentally-friendly alternatives to organometallic antifoulants that are efficacious at preventing biofouling by organisms such as the zebra mussel. Preferred antifoulant compositions utilize compounds having a Lipophilic-Amide-Spacer-ElectroNegative (“LASEN”) structural motif, such as capsaicin, and compounds having a TetraHydroCannibinoid (“THC”) structural motif. The antifoulant compositions are non-toxic, and effective.Type: ApplicationFiled: October 25, 2013Publication date: February 20, 2014Applicants: The Board of Regents of the University of Texas System, University of North Texas Health Science Center at Fort WorthInventors: John A. Schetz, Robert F. McMahon
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Patent number: 8642598Abstract: The present invention relates to a heterocyclic compound of the general formula (I) and their use and preparation, methods of making the compounds, compositions containing at least one of said compounds, and methods of treatment using at least one compound. In particular, compounds of the general formula (I) are useful for inhibiting glycogen synthase kinase 3 (GSK-3).Type: GrantFiled: October 19, 2007Date of Patent: February 4, 2014Assignees: AbbVie Inc., AbbVie Deutschland GmbH & Co. KGInventors: Sean C. Turner, Margaretha Henrica Maria Bakker, Kent D. Stewart
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Publication number: 20140018328Abstract: The present invention relates to compositions including anhydrous compositions which include a dimethicone crosspolymer and/or dimethicone elastomer gum and one or more skin care products which may include retinoic acid, retinoic acid derivatives, retinal, retinol and/or retinyl esters, and methods of making, storing, and using such compositions.Type: ApplicationFiled: August 7, 2013Publication date: January 16, 2014Applicant: Chemsil Silicones, Inc.Inventors: James Jefferies Harrison, Nohemi Harrison
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Patent number: 8623914Abstract: The object of the invention is to find the actions of the crude drugs contained in Daikenchuto or their components and the synergistic effect of the components with one another or with other pharmacologically active substances, and to provide new drugs or pharmaceutical compositions based on the findings. The invention is directed to intestinal peristaltic motility-enhancers comprising an effective amount of hydroxy-?-sanshool or a plant containing the same or an extract thereof; compositions comprising a combination of hydroxy-?-sanshool or a plant containing the same or an extract thereof and capsaicin or a plant containing the same or an extract thereof or bethanechol or a salt thereof; as well as a method for improving intestinal motility which comprises administering the composition to a patient.Type: GrantFiled: February 10, 2011Date of Patent: January 7, 2014Assignee: TSUMURA & Co.Inventor: Nobuhiro Ohtake
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Patent number: 8592484Abstract: Cosmetic compositions comprising calcium citrate and at least one N-acylated aminoalcohol according to formula (I). Provided is a method of treating aged skin, comprising topically applying to the aged skin a composition comprising a compound of Formula (I) in an amount effective to provide an anti-ageing effect. The compound of Formula (I) is used to prevent skin and/or to help to maintain or improve moisture retention and/or to fight against the signs of skin ageing. The N-acylated aminoalcohol of formula (I) acts as a ceramidase inhibitor. The combination of at least one compound of formula (I) and calcium citrate stimulates keratinocyte differentiation.Type: GrantFiled: March 16, 2010Date of Patent: November 26, 2013Assignee: Cognis IP Management GmbHInventors: Philippe Moussou, Olga Freis, Louis Danoux, Philippe Grisoni, Laurent Bailly
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Publication number: 20130304002Abstract: A dermal drug delivery system is provided which comprises at least two components, for example, a sheet of a solid and flexible material, and a vehicle liquid comprising a solvent and optionally other ingredients. A drug, which can be unstable in said solvent but needs the solvent for being delivered into the skin, can be impregnated in the sheet. Other ingredients, such as agents for fastening the drug on the sheet can also be impregnated in the sheet. These two components may be stored separately and joined either shortly before or at the time of application. To use the system, the vehicle liquid may be applied either on the target skin area or on the sheet, and the sheet may then be applied on the target skin area so that the vehicle liquid is positioned between the sheet and the skin and brought into contact with the ingredients impregnated in the sheet.Type: ApplicationFiled: November 8, 2011Publication date: November 14, 2013Inventor: Jie Zhang
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Publication number: 20130303620Abstract: The present invention provides compositions and methods for relieving pain at a site in a human or animal in need thereof by administering at a discrete site in a human or animal in need thereof a dose of capsaicin in an amount effective to denervate a discrete site without eliciting an effect outside the discrete location, the dose of capsaicin ranging from 1 ?g to 3000 ?g.Type: ApplicationFiled: April 12, 2013Publication date: November 14, 2013Applicant: Vallinex, Inc.Inventor: Vallinex, Inc.
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Patent number: 8580282Abstract: The present invention relates to tetracaine based anesthetic formulations and methods of use thereof. The invention further relates to topical formulations of tetracaine and methods of topically anesthetizing body tissues. The present invention also relates to tetracaine based dental anesthetic formulations and methods for anesthetizing the maxillary dental arch using these formulations.Type: GrantFiled: April 2, 2010Date of Patent: November 12, 2013Assignee: St. Renatus, LLCInventor: Mark David Kollar
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Publication number: 20130295159Abstract: A system and method for optimizing the systemic delivery of growth-arresting lipid-derived bioactive drugs or gene therapy agents to an animal or human in need of such agents utilizing nanoscale assembly systems, such as liposomes, resorbable and non-aggregating nanoparticle dispersions, metal or semiconductor nanoparticles, or polymeric materials such as dendrimers or hydrogels, each of which exhibit improved lipid solubility, cell permeability, an increased circulation half life and pharmacokinetic profile with improved tumor or vascular targeting.Type: ApplicationFiled: November 9, 2012Publication date: November 7, 2013Inventors: Mark Kester, Thomas Stover, Tao Lowe, James H. Adair, Young Shin Kim
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Publication number: 20130281294Abstract: Methods and compositions for controlling plant pests, particularly weeds and/or plant phytopathogens using sarmentine and/or analogs thereof are disclosed.Type: ApplicationFiled: June 17, 2013Publication date: October 24, 2013Inventors: HUAZHANG HUANG, Ratnakar Asolkar
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Publication number: 20130267571Abstract: The present application provides a terpene analogue of Formula (I) or a pharmaceutically acceptable isomer, salt or ester thereof, and methods and uses thereof for treating neurological conditions such as pain in general and neuropathic pain. These terpene analogues can also be used to treat other electrical disorders in the central and peripheral nervous system. Also provided are methods of synthesizing the terpene analogues of Formula I.Type: ApplicationFiled: September 14, 2011Publication date: October 10, 2013Applicant: NeuroQuest Inc.Inventors: Mark A. Reed, Donald Weaver, Shengguo Sun, Alexander McLellan, Erhu Lu
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Publication number: 20130266588Abstract: This invention relates generally to a therapeutic use of TLR3 and TLR7 inhibitors to treat or reduce pruritus in a subject.Type: ApplicationFiled: October 21, 2011Publication date: October 10, 2013Applicant: BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Ru-Rong Ji, Temugin Berta, Zhen-Zhong Xu, Tong Liu, Chul-Kyu Park
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Publication number: 20130252925Abstract: The present invention relates to TRPV1 selective agonist topical compositions including capsaicinoid and analgesic agent compositions and methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.Type: ApplicationFiled: March 12, 2013Publication date: September 26, 2013Applicant: API Genesis, LLCInventors: Daniel Bucks, Philip J. Birbara
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Publication number: 20130224318Abstract: The present invention describes methods for improving the appearance of skin, particularly, treating, ameliorating, preventing, delaying, and/or improving one or more signs of excess accumulation and/or production of subcutaneous fat, such as cellulite, and conditions related thereto, by topically applying compositions comprising Carnitine Palmitoyl Transferase-1 (CPT-1) modulators, optionally with other anti-lipid agents; and also describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating loss of subcutaneous fat in the skin, wherein the compositions include natural plant constituents that stimulate lipid synthesis.Type: ApplicationFiled: February 26, 2013Publication date: August 29, 2013Applicant: Avon Products, Inc.Inventor: Avon Products, Inc.
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Publication number: 20130217773Abstract: This invention is designed for the convenient and reliable delivery of predetermined doses of topical therapeutic medications applied to the skin. The importance of this method of application is that it allows reducing the amount of a therapeutic agent used in one session or reducing amount of sessions per day by eliminating the application of medications to a treating surface by hand. The emphasis is on making therapeutic agents available for self-administration, especially for partially disabled people with conditions such as arthritis and/or visual impairments who would not be able to use these medications without assistance.Type: ApplicationFiled: February 22, 2012Publication date: August 22, 2013Inventor: Mikhail Levitin