Silicon Containing Doai Patents (Class 514/63)
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Publication number: 20130296272Abstract: Heteroarylpiperidine and -piperazine derivatives of the formula (I) in which the symbols A, X, Y, L1, L2, G, Q, p, R1, R2 and R10 are each as defined in the description, and salts, metal complexes and N-oxides of the compounds of the formula (I), and the use thereof for controlling phytopathogenic harmful fungi and processes for preparing compounds of the formula (I).Type: ApplicationFiled: August 24, 2011Publication date: November 7, 2013Applicant: Bayer Intellectual Property GmbHInventors: Tomoki Tsuchiya, Pierre Wasnaire, Sebastian Hoffmann, Pierre Cristau, Thomas Seitz, Joachim Kluth, Stefan Hillebrand, Juergen Benting, Daniela Portz, Ulrike Wachendorff-Neumann
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Publication number: 20130296271Abstract: Agri-horticultural pest control compositions having outstanding control effect on pests, in particular, agri-horticultural pests, which comprise as active ingredients one or more 4-(3-butynyl)aminopyrimidine derivatives represented by the general formula [I], namely, where R1 is typically selected from among: a) phenyl c) —SiR5R6R7 (R5, R6, and R7 which may be the same or different represent a linear or branched alkyl having 1-6 carbon atoms, a linear or branched haloalkyl having 1-3 carbon atoms which is substituted by one halogen atom, a linear or branched cyanoalkyl having 1-3 carbon atoms which is substituted by one cyano group, and phenyl); d) hydropgen atom; R2 typically represents a hydrogen atom; R3 typically represents a hydrogen atom; R4 represents a hydrogen atom and one or more agri-horticultural pest control compounds selected from among agri-horticultural antimicrobial compounds, say, multi-site contact active compouns, nucleic acids synthesis inhibitory active compounds, mitosis and cellType: ApplicationFiled: December 27, 2011Publication date: November 7, 2013Applicant: SDS Biotech K.K.Inventors: Masaaki Sakai, Tomoaki Matsumura, Satohiro Midorikawa, Takashi Nomoto, Tomoko Muraki, Ryutaro Katsuki
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Publication number: 20130296270Abstract: The present invention provides a method for inhibiting microorganisms or plant pests using exfoliated clay/surfactant complex. The weight ratio of the exfoliated clay to the surfactant can range from 99/1 to 1/99. Preferably, the exfoliated clay is an inorganic layered clay on a nano scale and the surfactant is cationic, nonionic, anionic or amphoteric.Type: ApplicationFiled: July 2, 2013Publication date: November 7, 2013Inventors: Jiang-Jen Lin, Ying-Chiao Wang, Pei-Ru Li
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Publication number: 20130296269Abstract: The present invention relates to novel 5-halogenopyrazole(thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.Type: ApplicationFiled: November 14, 2011Publication date: November 7, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Jürgen Benting, Pierre-Yves Coqueron, Pierre Cristau, Peter Dahmen, Philippe Desbordes, Christophe Dubost, Stephanie Gary, Jörg Greul, Hiroyuki Hadano, Jean-Pierre Vors, Ulrike Wachendorff-Neumann
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Patent number: 8575133Abstract: The present invention relates to pigmented emulsion cosmetic compositions containing emulsifying silicone elastomers that provide a natural appearance to the skin upon application. In particular, these cosmetic compositions are formulated such that agglomeration of the pigment upon application to the skin is minimized.Type: GrantFiled: July 6, 2010Date of Patent: November 5, 2013Assignee: The Procter & Gamble CompanyInventors: Michael Lee Vatter, Jorge Max Sunkel, Curtis Bobby Motley
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Patent number: 8569385Abstract: The present invention provides for a composition comprising a silane having the formula: (R1)(R2)(R3)Si—R4—Si(R5)(R6)(R7) wherein R1, R2, R3, R5, and R6 are each independently selected from the group consisting of 1 to 6 monovalent hydrocarbon radicals, aryl, and a hydrocarbon group of 7 to 10 carbons containing an aryl group; R4 is a hydrocarbon group of 1 to 3 carbons; R7 comprises an anionic, cationic or zwitterionic substituent. The silanes of the present invention exhibit resistance to hydrolysis over a wide pH range.Type: GrantFiled: November 29, 2010Date of Patent: October 29, 2013Assignee: Momentive Performance Materials Inc.Inventors: Mark D. Leatherman, George A. Policello, Wenqing N. Peng, Liping Zeng, Ronald Wagner, Suresh K. Rajamaran, Zijun Xia
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Patent number: 8569265Abstract: The present invention discloses: (i) two novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, and/or derivatives thereof; (ii) methods of synthesis of said novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, and/or derivatives thereof; (iii) pharmaceutically-acceptable formulations comprising said novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, derivatives thereof; and/or, optionally, one or more additional chemotherapeutic agents; and (iv) methods of administration of said novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, derivatives thereof; and/or, optionally, one or more additional chemotherapeutic agents, to subjects in need thereof.Type: GrantFiled: May 6, 2011Date of Patent: October 29, 2013Assignee: BioNumerik Pharmaceuticals, Inc.Inventors: Xinghai Chen, Qiuli Huang, Harry Kochat, Andrey Malakhov, Frederick H. Hausheer
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Publication number: 20130280323Abstract: Disclosed herein is a soft elastic capsule that includes an acid resistant, capsule shell that defines an encapsulated space having a predetermined volume, a liquid or semisolid fill comprising a first active ingredient located within the encapsulated space, and a first compressed tablet a having a minimal dimension of 2 mm, being located within the encapsulated space, unanchored to the capsule shell, and surrounded by the fill, said tablet comprising a second active ingredient that is substantially insoluble in the fill. A method of manufacturing a soft elastic capsule is also disclosed.Type: ApplicationFiled: April 12, 2013Publication date: October 24, 2013Inventors: Qi Fang, Don A. Archibald, Madhu Sudan Hariharan, Roger E. Gordon
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Publication number: 20130281397Abstract: The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of cancer, including NUT midline carcinoma, Burkitt's Lymphoma, Acute Myelogenous Leukemia, and Multiple Myeloma; autoimmune or inflammatory diseases or conditions, and sepsis.Type: ApplicationFiled: March 15, 2013Publication date: October 24, 2013Applicant: RVX Therapeutics Inc.Inventors: Kevin G. McLure, Peter Ronald Young
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Publication number: 20130280391Abstract: Disclosed herein are anti-microbial wash compositions and methods for using such compositions in controlling microbe growth on a non-meat food product (e.g., fruits, vegetables, grains, eggs, etc.) by applying or contacting the anti-microbial wash composition with a surface of the food product to kill microbes (e.g., bacteria) on a surface of the food product. The anti-microbial wash compositions include a ceragenin compound dispersed in a fluid carrier. The ceragenin compound includes a sterol backbone and a number of cationic groups attached to the sterol backbone. The cationic groups may be attached to the sterol backbone by a hydrolysable linkage so that the ceragenin compound has a relatively short half life (e.g., less than about 40 days), and the wash composition may be applied prior to shipping and washed off after shipping to minimize any ceragenin compound residue.Type: ApplicationFiled: March 15, 2013Publication date: October 24, 2013Applicant: BRIGHAM YOUNG UNIVERSITYInventor: Paul B. Savage
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Publication number: 20130281402Abstract: The disclosure includes hydroxamic compounds of Formula I: (Formula I) wherein Z, L, R1, R2, and R3 are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compounds.Type: ApplicationFiled: January 6, 2012Publication date: October 24, 2013Applicant: CRYSTAL BIOPHARMACEUTICAL LLCInventors: Yi Chen, Yu Chen
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Publication number: 20130280211Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.Type: ApplicationFiled: June 17, 2013Publication date: October 24, 2013Inventors: Carol Bachand, Makonen Belema, Daniel H. Deon, Andrew C. Good, Jason Goodrich, Clint A. James, Rico Lavoie, Omar D. Lopez, Alain Martel, Nicholas A. Meanwell, Van N. Nguyen, Jeffrey Lee Romine, Edward H. Ruediger, Lawrence B. Snyder, Denis R. ST. Laurent, Fukang Yang, David R. Langley, Lawrence G. Hamann
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Patent number: 8563604Abstract: This invention is a composition comprising a cyclic siloxane, a silicone occlusive fluid, a silicone occlusive gel, and a silicone resin powder. The composition is useful for wound healing.Type: GrantFiled: September 30, 2008Date of Patent: October 22, 2013Assignee: Valeant Pharmaceuticals InternationalInventors: Irwin Palefsky, Ni'Kita Wilson
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Patent number: 8563072Abstract: The present invention relates to hydronium stabilized silicic acid nanoparticles, to the formulation obtained from the said diluted suspension, to the powder obtained from the said dehydrated suspension and to the preparation or dosage form obtained from the said suspension, formulation or powder, to their preparation and their use in all kinds of applications in the domains of food, medicine, pharmaceutics, cosmetics. The present invention provides a stable suspension of colloidal silicic acid nanoparticles having a pH lower than 0.9, a molar silicon concentration between 0.035 and 0.65, a free water concentration of at least 30% (w/v) and a ratio between hydronium ion and Si molar concentrations higher than 2 and preferably inferior to 4.Type: GrantFiled: April 16, 2009Date of Patent: October 22, 2013Assignees: Aquarius Investholding, SARL, Jisbrey, S.A.Inventors: Ivo Suvee, Guillaume Tourgis
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Publication number: 20130273132Abstract: An office furnishing is provided that may include one or more surfaces coated with an antimicrobial treatment, which may include a silane quaternary ammonium salt and isopropyl alcohol. The silane quaternary ammonium salt may include an unreacted organofunctional silane to promote bonding to the surfaces of the office furnishing, such as 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride. The office furnishing article may include one of: a desk; a chair; a table; a bookcase; a hutch; shelves; an office divider panel; a file cabinet; a fax machine; a telephone; a computer; a keyboard; a monitor; a computer mouse; a book; a lamp; a binder; a stapler; an office stamp; and a desk pad. A method is also provided for coating these office furnishing articles with the antimicrobial treatment.Type: ApplicationFiled: April 17, 2012Publication date: October 17, 2013Inventor: Patrick E. Eddy
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Publication number: 20130274226Abstract: The invention provide a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles described herein.Type: ApplicationFiled: November 30, 2011Publication date: October 17, 2013Applicant: The Board of Trustees of the University of IllinoisInventors: Jianjun Cheng, Li Tang
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Publication number: 20130273133Abstract: A hospital bed is provided that may include a support structure having a plurality of surfaces coated with an antimicrobial treatment, which may include a silane quaternary ammonium salt and isopropyl alcohol. The silane quaternary ammonium salt may include an unreacted organofunctional silane to promote bonding to the surfaces of the bed, such as 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride. Bed accessories, such as tables and IV stands, may also include the antimicrobial treatment. A method is also provided for coating these articles with the antimicrobial treatment.Type: ApplicationFiled: April 17, 2012Publication date: October 17, 2013Inventor: Patrick E. Eddy
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Patent number: 8557293Abstract: A sunscreen composition for application for plants comprises Titanium Dioxide (TiO2), Zinc Oxide (ZnO), Silicon Dioxide (SiO2), a surfactant, wetting agent, dispersant (SWD) and water. The composition forms a suspension concentrate when combined that when diluted in water provides a solution that provides uniform coverage using convention spraying equipment. A method of protecting plants including turfgrass from ultraviolet radiation, heat stress and/or sunburn comprises combining TiO2, ZnO, SiO2, SWD and water to form a suspension concentrate. The suspension concentrate is then diluted in water and applied to an area in which sun protection is desired.Type: GrantFiled: August 26, 2010Date of Patent: October 15, 2013Inventor: Scott May
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Publication number: 20130261081Abstract: A heterocyclic compound represented by the general formula (1) or a salt thereof: wherein m, l, and n respectively represent an integer of 1 or 2; X represents —O— or —CH2—; R1 represents hydrogen, a lower alkyl group, a hydroxy-lower alkyl group, a protecting group, or a tri-lower alkylsilyloxy-lower alkyl group; R2 and R3, which are the same or different, each independently represent hydrogen or a lower alkyl group; or R2 and R3 are bonded to form a cyclo-C3-C8 alkyl group; and R4 represents an aromatic group or a heterocyclic group, wherein the aromatic or heterocyclic group may have one or more arbitrary substituent(s).Type: ApplicationFiled: September 12, 2011Publication date: October 3, 2013Inventors: Nobuaki Ito, Hirofumi Sasaki, Kuninori Tai, Tomoichi Shinohara
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Publication number: 20130252922Abstract: The present invention relates to substituted phenoxypyridine compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: October 27, 2011Publication date: September 26, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventor: Marion Hitchcock
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Publication number: 20130243704Abstract: The invention relates to a cosmetic composition comprising a cosmetically acceptable vector and polyorganosiloxane. The polyorganosiloxane comprises a group that includes a sterically hindered amine, and a polyalkoxyl group.Type: ApplicationFiled: February 25, 2013Publication date: September 19, 2013Applicant: RHODIA CHIMIEInventors: Melissa Manuszak, Giles Lorentz
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Patent number: 8535697Abstract: Provided are a cosmetic composition which is an O1/W/O2 emulsion composition and contains, in the oil phases O1 and O2 thereof, fine metal oxide particles having ultraviolet screening ability; and a preparation process of the cosmetic composition.Type: GrantFiled: November 17, 2006Date of Patent: September 17, 2013Assignee: Kao CorporationInventors: Yukio Inomata, Toshio Uesaka, Satoshi Sugawara, Yasumitsu Sakuma, Masahiro Umehara
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Publication number: 20130237499Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.Type: ApplicationFiled: March 1, 2013Publication date: September 12, 2013Applicant: Bristol-Myers Squibb CompanyInventors: Zhizhen Barbara Zheng, Stanley D'Andrea, David R. Langley, B. Narasimhulu Naidu
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Publication number: 20130237500Abstract: The present invention relates to novel (thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.Type: ApplicationFiled: November 14, 2011Publication date: September 12, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Juergen Benting, Philippe Desbordes, Stephanie Gary, Joerg Greul, Tomoki Tsuchiya, Ulrike Wachendorff-Neumann
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Publication number: 20130236412Abstract: Disclosed are hair or skin conditioning compositions comprising by weight: (a) from about 0.1% to about 10% of a thickening polymer system; (b) from about 0.1% to about 8.0% of a surfactant system selected from the group consisting of cationic surfactant, nonionic surfactant, and mixtures thereof; (c) from about 0.1% to about 10% of a hydrophobically modified amido silicone copolyol; and (d) an aqueous carrier; wherein the composition has a transmittance of 25% or more and/or wherein the composition has a viscosity of from about 1,000 cps to about 50,000 cps and Shear Thinning Index of 30 or more. The compositions are especially suitable for hair care products such as hair conditioning products for rinse-off/leave-on use.Type: ApplicationFiled: March 22, 2013Publication date: September 12, 2013Applicant: The Procter & Gamble CompanyInventors: Nobuaki UEHARA, Satomi ASARI, Natsumi KOMURE
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Patent number: 8530381Abstract: The invention relates to active compound combinations, in particular within a composition, which comprises (A) an amidine compound of formula (I) and a further fungicidally (B-1), insecticidally (B-2) active or plant growth regulating compound (B-3). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or reducing the mycotoxin contamination of plant or plant parts, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.Type: GrantFiled: December 16, 2010Date of Patent: September 10, 2013Assignee: Bayer CropScience AGInventors: Kerstin Ilg, Ulrich Heinemann, Peter Dahmen, Ulrike Wachendorff-Neumann
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Patent number: 8530451Abstract: An ectoparasiticidal composition is provided that comprises a mixture of a carrier and an active with an emulsifying agent. The carrier comprises non-volatile low viscosity siloxane and the active comprises a non-volatile high viscosity siloxane. The low viscosity siloxane and the high viscosity siloxane both have a closed cup flash point of at least 100° C. Preferably, both the low viscosity siloxane and the high viscosity siloxane comprise a dimeticone or a dimeticonol or a mixture of same, the the low viscosity siloxane having a viscosity in the range of 5 to 1000 centistokes inclusive and the high viscosity siloxane having a viscosity of at least 1000 centistokes.Type: GrantFiled: May 12, 2010Date of Patent: September 10, 2013Assignee: Thornton & Ross LimitedInventor: Nigel Cooper
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Publication number: 20130231599Abstract: An adhesive formulation is provided for use in a film wound dressing. The adhesive formulation includes a medical-grade adhesive and an antimicrobial substance. This adhesive formulation may be coated onto one or more surfaces of a medical-grade transparent film suitable for a wound dressing. The antimicrobial material may be a silane quaternary ammonium salt. The silane quaternary ammonium salt may comprise 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride. The 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride may constitute about 72% of the silane quaternary ammonium salt. The medical-grade adhesive may comprise an acrylic adhesive. Further, the adhesive formulation may include about 0.01% to about 60% of the antimicrobial substance. The transparent film dressing may further include a release liner applied over the coated side(s) of the transparent film. The transparent film may comprise polyurethane.Type: ApplicationFiled: February 28, 2013Publication date: September 5, 2013Inventor: Patrick E. Eddy
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Publication number: 20130231303Abstract: The present invention relates to novel 5-halogenopyrazole(thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.Type: ApplicationFiled: November 14, 2011Publication date: September 5, 2013Applicant: Bayer Intellectual Property GmbHInventors: Juergen Benting, Pierre Cristau, Peter Dahmen, Philippe Desbordes, Stephanie Gary, Joerg Greul, Hiroyuki Hadano, Jan Peter Schmidt, Tomoki Tsuchiya, Ulrike Wachendorff-Neumann, Lars Rodefeld
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Patent number: 8524214Abstract: Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described.Type: GrantFiled: May 27, 2010Date of Patent: September 3, 2013Assignee: Mersana Therapeutics, Inc.Inventors: Aleksandr Yurkovetskiy, Mao Yin, Gui Liu, Laura C. Akullian, John J. Kane, Cheri A. Stevenson, Charles E. Hammond, Russell C. Petter, John H. Van Duzer, Timothy B. Lowinger
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Publication number: 20130224107Abstract: Disclosed are heterocyclic derivatives, methods for making them, compositions containing the same and uses thereof. Particularly, their pharmaceutical use as inhibitors of PARP is disclosed.Type: ApplicationFiled: December 2, 2010Publication date: August 29, 2013Applicant: SHANGHAI DE NOVO PHARMATECH CO LTD.Inventor: Daxin Gao
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Publication number: 20130217650Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.Type: ApplicationFiled: November 15, 2012Publication date: August 22, 2013Applicant: Allergan, Inc.Inventor: Allergan, Inc.
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Patent number: 8512723Abstract: Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including, in particular, an antimicrobial lipid component, such as a fatty acid ester, fatty ether, or alkoxide derivative thereof. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and/or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and/or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).Type: GrantFiled: September 8, 2004Date of Patent: August 20, 2013Assignee: 3M Innovative Properties CompanyInventors: Matthew T. Scholz, Dianne L. Gibbs, John T. Capecchi, Jeffrey F. Andrews
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Publication number: 20130210769Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).Type: ApplicationFiled: March 15, 2013Publication date: August 15, 2013Applicant: IRM LLCInventors: Hong Liu, Xiaohui He, Dean Paul Phillips, Xuefeng Zhu, Kunyong Yang, Thomas Lau, Baogen Wu, Yongping Xie, Truc Ngoc Nguyen, Xing Wang
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Publication number: 20130210768Abstract: The present invention is directed to 5-substituted 1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-one derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.Type: ApplicationFiled: June 6, 2011Publication date: August 15, 2013Inventors: Kenneth L. Arrington, Vadim Dudkin, Mark E. Layton, Joseph E. Pero, Alexander J. Reif
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Publication number: 20130210767Abstract: An aqueous biocidal composition comprising: (a) a compound of formula (II): or a derivative salt thereof wherein L is a linking group; each of R1, R2 and R3 is independently selected from an optionally substituted alkyl, alkenyl, aryl or alkoxy group; R4 is oxygen or an optionally substituted alkyl, alkenyl or aryl group; each of R5 and R6 is an optionally substituted alkyl, alkenyl or aryl group; and n is 0 or 1; (b) a hydrocarbyl saccharide compound; and (c) at least one cationic biocide; wherein the molar ratio of component (b) to component (a) is at least 0.5:1.Type: ApplicationFiled: February 28, 2011Publication date: August 15, 2013Applicant: Arcis Biotechnology LimitedInventor: George Victor Garner
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Publication number: 20130203675Abstract: Asymmetric bifunctional silyl (ABS) monomers comprising covalently linked pharmaceutical, chemical and biological agents are described. These agents can also be covalently bound via the silyl group to delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain ABS monomers comprising covalently linked agents and to vehicles that are covalently linked to the ABS monomers. The silyl modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting.Type: ApplicationFiled: September 15, 2011Publication date: August 8, 2013Inventors: Joseph M. DeSimone, Matthew Finniss, Mary Napier, Ashish Pandya, Matthew Parrott
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Publication number: 20130203592Abstract: This document discloses molecules having the following formulas (“Formula One” &“Formula Two” and “Formula Three”) The Ar1, Het, Ar2, R1, R2, R3, R4, and R5 are further described herein.Type: ApplicationFiled: January 22, 2013Publication date: August 8, 2013Applicant: Dow AgroSciences LLCInventor: Dow AgroSciences LLC
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Publication number: 20130203593Abstract: This document discloses molecules having the following formulas (“Formula One” & “Formula Two” and “Formula Three”) The Ar1, Het, Ar2, R1, R2, R3, R4, and R5 are further described herein.Type: ApplicationFiled: January 23, 2013Publication date: August 8, 2013Applicant: Dow AgroSciences LLCInventor: Dow AgroSciences LLC
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Publication number: 20130196950Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.Type: ApplicationFiled: December 7, 2012Publication date: August 1, 2013Applicant: University Of WashingtonInventor: University of Washingon
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Publication number: 20130196951Abstract: The present invention is directed to compositions comprising at least one nitric oxide donor and at least one second therapeutically active agent with antimicrobial or wound healing capability. In one embodiment, the nitric oxide donor is a nanoparticle which is designed to control for the amount and duration of release of nitric oxide. The nanoparticle may further comprise the additional therapeutically active agent. The composition is useful for enhancing wound healing and for treating and preventing microbial infection. In one embodiment, the composition is directed toward reducing oral bacteria or dental plaque. The combination of one or more nitric oxide donors and one or more additional therapeutically active agent results in unexpected synergistic effects, wherein both the antimicrobial efficacy of the nitric oxide and the antimicrobial or wound healing efficacy of the second therapeutically active agent are enhanced.Type: ApplicationFiled: March 11, 2013Publication date: August 1, 2013Applicant: UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILLInventor: UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
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Publication number: 20130190271Abstract: Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A1 and A2 independently represent a nitrogen atom or the like; R1 and R4 independently represent a halogen atom or the like; R2 and R3 independently represent a halogen atom or the like; R5 and R6 independently represent a linear C1-C6 hydrocarbon group which may be substituted, or the like (provided that both R5 and R6 cannot represent a hydrogen atom simultaneously); and n represents 0 or 1]. The harmful arthropod control composition has an excellent efficacy to control harmful arthropods.Type: ApplicationFiled: March 8, 2013Publication date: July 25, 2013Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Sumitomo Chemical Company, Limited
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Publication number: 20130190272Abstract: The present invention provides a composition having an excellent controlling activity on a pest. The composition comprising a compound represented by Formula (1) and one or more pyrethroid compound(s) selected from Group (A) shows an excellent controlling activity on a pest.Type: ApplicationFiled: October 13, 2011Publication date: July 25, 2013Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: So Kiguchi, Soichi Tanaka
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Publication number: 20130184238Abstract: The present invention relates to aminotetraline derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminotetraline derivatives, and the use of such aminotetraline derivatives for therapeutic purposes. The aminotetraline derivatives are GlyT1 inhibitors.Type: ApplicationFiled: March 8, 2013Publication date: July 18, 2013Inventors: AbbVie Deutschland GmbH & Co. KG, AbbVie Inc.
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Publication number: 20130184239Abstract: The invention relates to a pharmaceutical composition comprising a siloxane according to general formula (I)< wherein R means —C1-C6-alkyl; R1 and R2 each mean independently of one another —C1-C6-alkyl, or together form a (2n)-membered ring; and n is an integer of from 2 to 8; for use in combination with a pharmacologically active ingredient in the prophylaxis or treatment of a dental disorder.Type: ApplicationFiled: July 13, 2011Publication date: July 18, 2013Applicant: BAYER INNOVATION GMBHInventor: Hans H. Schulz
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Publication number: 20130172292Abstract: The present invention provides a compound which has the effect of PDE 10A inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on.Type: ApplicationFiled: August 3, 2011Publication date: July 4, 2013Applicant: Takeda Pharmaceutical Company LimitedInventors: Joseph Raker, Takahiko Taniguchi, Masato Yoshikawa, Tomoaki Hasui, Jun Kunitomo
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Publication number: 20130165409Abstract: A phenyl carbamate compound; a composition for treating and/or alleviating pain containing the phenyl carbamate compound or a pharmaceutically acceptable salt thereof as an active ingredient; a method of treating and/or alleviating pain comprising administering the phenyl carbamate compound or a pharmaceutically acceptable salt thereof to a patient in need of pain treatment; and a use of the phenyl carbamate compound or a pharmaceutically acceptable salt thereof in treating and/or alleviating pain, are provided.Type: ApplicationFiled: December 27, 2012Publication date: June 27, 2013Applicant: Bio-Pharm Solutions Co., Ltd.Inventor: Bio-Pharm Solutions Co., Ltd.
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Publication number: 20130165410Abstract: A phenyl carbamate compound; a composition for treating and/or preventing stroke containing the phenyl carbamate compound or a pharmaceutically acceptable salt thereof as an active ingredient; a method of treating and/or preventing stroke comprising administering the phenyl carbamate compound or a pharmaceutically acceptable salt thereof to a patient in need of stroke treatment; and a use of the phenyl carbamate compound or a pharmaceutically acceptable salt thereof in treating and/or preventing stroke, are provided.Type: ApplicationFiled: December 27, 2012Publication date: June 27, 2013Applicant: Bio-Pharm Solutions Co., Ltd.Inventor: Bio-Pharm Solutions Co., Ltd.
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Publication number: 20130165408Abstract: A method for treatment or prevention epilepsy comprising administering a phenyl carbamate compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of epilepsy is provided.Type: ApplicationFiled: December 27, 2012Publication date: June 27, 2013Applicant: Bio-Pharm Solutions Co., Ltd.Inventor: Bio-Pharm Solutions Co., Ltd.
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Publication number: 20130157976Abstract: The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general formulae (I) and (II), and to their preparation and use as medicaments, especially for the treatment of malignant disorders and other disorders based on pathological cell proliferations.Type: ApplicationFiled: February 19, 2013Publication date: June 20, 2013Inventors: Eckhard CLAUS, Irene Seipelt, Eckhard Guenther, Emmanuel Polymeropoulos, Michael Czech, Tilmann Schuster