Polyether Patents (Class 514/668)
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Publication number: 20150094379Abstract: Amine compounds, amine polymers, crosslinked amine polymers and pharmaceutical compositions comprising the same may include polyhydroxy-containing cores that may be substituted with amine groups and may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.Type: ApplicationFiled: November 24, 2014Publication date: April 2, 2015Inventors: Christopher COOPER, Pradeep K. DHAL, Rayomand GIMI, David J. HARRIS, Stephen Randall HOLMES-FARLEY, Chad C. HUVAL, Edward R. LEE
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Publication number: 20140302564Abstract: A method for sterilizing microbial cells is provided. According to the method, microbial cells or a culture containing microbial cells are treated with a polyethylene glycol-based nonionic surfactant so that almost all of the microbial cells are sterilized while the enzyme activity expressed in the microbial cells is maintained at a high level. A method for sterilizing microbial cells and a material containing the sterilized microbial cells, in which the microbial cells are sterilized using a polyethylene glycol-based nonionic surfactant, can be used for foods so that the microbial cells are sterilized to be used in food production. Further, a material containing sterilized microbial cells can be used in processes for preparing tagatose, in which Corynebacterium genus microbial cells that produce Galactose and/or Arabinose isomerase are sterilized using a polyethylene glycol-based nonionic surfactant.Type: ApplicationFiled: June 20, 2014Publication date: October 9, 2014Inventors: Jin Ha Kim, Yong Mi Lee, Seong Bo Kim, Taek Beom Kim, Yang Hee Kim, Seung Won Park
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Patent number: 8829055Abstract: A drug and a composition for inhibiting biofilm formation are provided. A biofilm formation inhibitor composition containing the following component (A): (A) at least one or more selected from compounds represented by Formula (1) to Formula (4): wherein R1 to R5 each represent an alkyl group or the like; EO represents an ethyleneoxy group; p represents an integer from 0 to 5; and m+n represents a number from 0 to 30, or a salt thereof; and (B) a surfactant.Type: GrantFiled: March 23, 2007Date of Patent: September 9, 2014Assignee: Kao CorporationInventors: Tetsuya Okano, Shinya Iwasaki, Kazuo Isobe, Eiko Ishizuka
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Publication number: 20140171320Abstract: The present invention relates to a composition comprising a pesticide and an alkoxylate. The invention further relates to the alkoxylate, to a method for the production thereof and to the use thereof as adjuvant in pesticide-comprising spray mixtures. The invention further relates to a method for controlling phytopathogenic fungi and/or undesirable plant growth and/or undesirable insect or mite infestation and/or for regulating the growth of plants, wherein the composition is allowed to act on the respective pests, the habitat thereof or the plants to be protected from the respective pest, on the soil and/or on undesirable plants and/or the crop plants and/or the habitat thereof. Furthermore, the invention relates to seed comprising the composition.Type: ApplicationFiled: December 13, 2013Publication date: June 19, 2014Applicant: BASF SEInventors: Frederic Bauer, Paul Klingelhoefer, Christof Wilhelm Wigbers, Eva-Maria Reis-Walther
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Publication number: 20140017506Abstract: The present application relates to wood preservation, for example, surfactants and phospholipids for improving wood preservation. Included are surfactants and phospholipids containing a 2-amino-N,N-dimethylacetamide. Provided are wood preservative compositions containing these surfactants or phospholipids, methods of applying such wood preservative compositions to wood, and wood products resultant from some such methods. Also provided are wood products containing the wood preservative compositions provided herein.Type: ApplicationFiled: July 16, 2012Publication date: January 16, 2014Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLCInventor: Atsushi Mizusawa
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Patent number: 8618179Abstract: The present invention relates to a composition comprising a pesticide and an alkoxylate. Moreover, the invention relates to the alkoxylate, to a process for its preparation and to its use as adjuvant in pesticide-comprising spray mixtures. The invention furthermore relates to a method of controlling phytopathogenic fungi and/or undesired vegetation and/or undesired insect or mite attack and/or for regulating the growth of plants, wherein the composition is allowed to act on the respective pests, their environment or the plants to be protected from the respective pest, on the soil and/or on undesirable plants and/or the crop plants and/or their environment. Furthermore, the invention relates to seed comprising the composition.Type: GrantFiled: January 14, 2011Date of Patent: December 31, 2013Assignee: BASF SEInventors: Paul Klingelhoefer, Arend Jouke Kingma, Sophie Vogel, Kevin Huyghe, Gerd Haderlein, Gerhard Schnabel, Marc Nolte, Richard Roger Evans
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Publication number: 20130331262Abstract: The present invention relates to a composition comprising a pesticide, a surfactant and an alkoxylate. Moreover, the invention relates to a concentrate comprising the surfactant and the alkoxylate; and to a process for preparing the composition by bringing into contact the concentrate and a pesticide; or by bringing into contact the pesticide, the surfactant and the alkoxylate; and to the use of the surfactant by addition to a mixture comprising the pesticide and the alkoxylate. The invention furthermore relates to a method of controlling phytopathogenic fungi and/or undesired vegetation and/or undesired insect or mite attack and/or for regulating the growth of plants, wherein the composition is allowed to act on the respective pests, their environment or the plants to be protected from the respective pest, on the soil and/or on undesirable plants and/or the crop plants and/or their environment. Furthermore, the invention relates to seed comprising the composition.Type: ApplicationFiled: February 27, 2012Publication date: December 12, 2013Applicant: BASF SEInventors: Gerhard Schnabel, Paul Klingelhoefer, Marc Nolte, Richard Roger Evans, Gerd Kraemer, Silke Zeyer, Matthias Pfenning
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Publication number: 20130156724Abstract: The invention describes for first time the activity of poloxamines as inducers in the differentiation of mesenchymal or progenitor cells. In particular, the invention demonstrates that poloxamines have an osteogenic ability. The invention relates to the use of one or more poloxamines or a pharmaceutical composition comprising same for the preparation of a drug for treting patients with bone defects in general. The invention also relates to a method for inducing the differentiation of mesenchymal or progenitor cells into osteoblasts by bringing said cells into contact with a sterilised aqueous dispersion or solution of one or more poloxamines.Type: ApplicationFiled: May 12, 2011Publication date: June 20, 2013Applicant: UNIVERSIDADE DE SANTIAGO DE COMPOSTELAInventors: Carmen Alvarez Lorenzo, Ana Rey Rico, Teresa Silva Rivera, José Couceiro Follente, Angel Concheiro Nine
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Patent number: 8318144Abstract: The use of poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses. Such compounds are also useful for cleaning purposes. The use of the compounds as surfactants in various types of compositions for treating contact lenses therefore represents a preferred embodiment of the present invention.Type: GrantFiled: December 10, 2007Date of Patent: November 27, 2012Assignee: Alcon Research, Ltd.Inventors: Howard Allen Ketelson, Nathaniel D. McQueen
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Patent number: 8192743Abstract: Activated polymeric bicine derivatives such as, as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.Type: GrantFiled: July 25, 2008Date of Patent: June 5, 2012Assignee: Enzon Pharmaceuticals, Inc.Inventors: Hong Zhao, Richard B. Greenwald, Susan L. Adler, legal representative
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Publication number: 20120122949Abstract: [Problem] The present invention is intended to provide high-strength hydrogels and method for fabricating the same. The present invention is intended to provide the method for fabricating the hydrogels with different decomposition rates. [Solution to Problem] The present invention is based on a knowledge that high-strength hydrogels can be fabricated by controlling pH of solution, ionic strength in the solution, and buffer concentration in the solution. In addition, the present invention is based on a knowledge that the high-strength hydrogels which have homogeneous macromolecular network structure can be fabricated by polymerizing four-branching compounds after having dispersed the four-branching compounds homogeneously.Type: ApplicationFiled: June 19, 2009Publication date: May 17, 2012Applicants: THE UNIVERSITY OF TOKYO, NEXT21 K.K.Inventors: Yuichi Tei, Takamasa Sakai, Nobuo Sasaki, Mitsuhiro Shibayama, Shigeki Suzuki
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Patent number: 8105623Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. The polymer compositions comprise polymerized fluorinated polyether monomer end-capped with ethylenically unsaturated cationic hydrophilic groups.Type: GrantFiled: June 30, 2006Date of Patent: January 31, 2012Assignee: Bausch & Lomb IncorporatedInventors: Derek Schorzman, Jay Kunzler
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Patent number: 8030358Abstract: A composition for removing a radioactive element or compound such as systemic transuranic compounds, from mammals comprises a pharmaceutical carrier and a decorporation agent comprising ester and amide derivatives of DTPA. A method of treating a mammal to remove systemic compounds utilizing the DTPA derivatives is also disclosed.Type: GrantFiled: October 29, 2008Date of Patent: October 4, 2011Assignee: University of Kentucky Research FoundationInventors: Michael Jay, Russell J. Mumper
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Publication number: 20110142952Abstract: This invention relates to crosslinked amine-containing polymers for binding compounds or ions, and more specifically relates to pharmaceutically acceptable compositions for binding compounds or ions that include crosslinked amine-containing polymers. The pharmaceutically acceptable composition includes, for example, crosslinked polyamine particles, or pharmaceutically acceptable salts thereof, having a particle size distribution wherein greater than 10 vol. % of the particles have a particle size greater than 500 ?m.Type: ApplicationFiled: June 17, 2009Publication date: June 16, 2011Inventors: David J. Harris, Stephen Randall Holmes-Farley, Steven C. Polomoscanlk, Adnan Salameh, Bruce Shutts, Richard Silva
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Patent number: 7897647Abstract: Activated polymeric bicine derivatives such as as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.Type: GrantFiled: August 9, 2006Date of Patent: March 1, 2011Assignee: Enzon Pharmaceuticals, Inc.Inventors: Hong Zhao, Richard B. Greenwald, Annapurna Pendri
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Publication number: 20100297104Abstract: The present invention is in relation to a dendritic molecule having symmetrically sited branches having four or more generations of dendrimers wherein the branch points are tertiary amines linked together with oxygen atom of ether and the heteroatoms are separated by a substituted or non-substituted linear three methylene linker. In addition the invention also provides a process to prepare such dendritic macromolecules.Type: ApplicationFiled: August 14, 2007Publication date: November 25, 2010Applicant: INDIAN INSTITUTE OF SCIENCEInventors: Jayaraman Narayanaswamy, Jayamurugan Govindasamy
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Publication number: 20100234309Abstract: Amine compounds, amine polymers, crosslinked amine polymers and pharmaceutical compositions comprising the same may include polyhydroxy-containing cores that may be substituted with amine groups and may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.Type: ApplicationFiled: August 31, 2007Publication date: September 16, 2010Applicant: Genzyme CorporationInventors: Christopher Cooper, Pradeep K. Dhal, Rayomand H. Gimi, David J. Harris, Stephen Randall Holmes-Farley, Chad C. Huval, Edward Lee
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Publication number: 20100221213Abstract: The present invention relates to Y-shape branched PEG derivatives of formulae (I) to (IV). The present invention also relates to conjugates of these Y-shape derivatives and drug molecules, pharmaceutical compositions comprising those conjugates.Type: ApplicationFiled: May 17, 2010Publication date: September 2, 2010Inventors: Shishan Ji, Dequan Zhu
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Publication number: 20100167926Abstract: The present invention relates to 3-substituted phenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the phenoxyamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.Type: ApplicationFiled: March 4, 2008Publication date: July 1, 2010Applicant: Bayer CropScience AGInventors: Klaus Kunz, Ralf Dunkel, Jorg Nico Greul, Kerstin Ilg, Birgit Kuhn, Wahed Ahmed Moradi, Thomas Seitz, Darren James Mansfield, Oliver Guth, Peter Dahmen, Ulrike Wachendorff-Neumann, Arnd Voerste, Robert Dale Mitchell, Tom Hough
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Patent number: 7629386Abstract: The use of compositions containing one or more antimicrobial agents with one or more trialkanolamine alkoxylate buffers to disinfect and/or preserve medical devices is described. Solutions containing one or more antimicrobial agents with one or more trialkanolamine alkoxylate buffers and methods of making and using the same are also described.Type: GrantFiled: August 26, 2004Date of Patent: December 8, 2009Assignee: Bausch + Lomb IncorporatedInventors: Joseph C. Salamone, Roya Nicole Borazjani, Daniel M. Ammon, Jr.
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Patent number: 7601872Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wType: GrantFiled: January 21, 2005Date of Patent: October 13, 2009Assignee: Life Technologies CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7393825Abstract: Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (½ to 1/20) of those known to induce vasodilation in “normal” circulations.Type: GrantFiled: June 11, 2003Date of Patent: July 1, 2008Assignee: Strakan International LimitedInventors: Jeremy P. W. Heaton, Michael A. Adams, James D. Banting
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Publication number: 20080003261Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. The polymer compositions comprise polymerized fluorinated polyether monomer end-capped with ethylenically unsaturated cationic hydrophilic groups.Type: ApplicationFiled: June 30, 2006Publication date: January 3, 2008Inventors: Derek Schorzman, Jay Kunzler
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Patent number: 7250157Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.Type: GrantFiled: October 14, 2005Date of Patent: July 31, 2007Assignee: Applied Genetics Incorporated DermaticsInventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
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Patent number: 7145039Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L?—X2—Z or —Z; R1–R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D—Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, andType: GrantFiled: January 21, 2005Date of Patent: December 5, 2006Assignee: Invitrogen Corp.Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7122189Abstract: Activated polymeric bicine derivatives such as as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.Type: GrantFiled: August 13, 2002Date of Patent: October 17, 2006Assignee: Enzon, Inc.Inventors: Hong Zhao, Richard B. Greenwald, Annapurna Pendri
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Patent number: 7087229Abstract: Activated polymeric bicine derivatives such as, as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.Type: GrantFiled: May 30, 2003Date of Patent: August 8, 2006Assignee: Enzon Pharmaceuticals, Inc.Inventors: Hong Zhao, Richard B. Greenwald
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Patent number: 7060731Abstract: This application relates to the use of certain amines of formula (I) for combatting and preventing systemic and local complement activation, and in particular to the use of meglumine and derivatives and optionally salts thereof in combatting and preventing said activation. The amines are also of use in combatting activation of the kinin/kallikrein system or blood coagulation system.Type: GrantFiled: September 12, 2002Date of Patent: June 13, 2006Assignee: Amersham Health ASInventors: Anne Juelsrud, Gunn Ragnhild Hoigaard Bjerke
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Patent number: 6955804Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.Type: GrantFiled: September 22, 2003Date of Patent: October 18, 2005Assignee: Applied Genetics Incorporated DematicsInventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
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Patent number: 6946484Abstract: Methods and formulations for inhibiting and preventing a malignant cell phenotype by administering to cells a low dose of a nitric oxide mimetic are provided.Type: GrantFiled: April 26, 2001Date of Patent: September 20, 2005Assignee: Cellegy Pharmaceuticals, Inc.Inventors: Michael A. Adams, Charles H. Graham, Jeremy P. W. Heaton, Lynne-Marie Postovit
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Patent number: 6932985Abstract: Disclosed is both a method and composition for controlling deleterious organisms, such as insects, nematodes and weeds by applying a compound comprised of a liquid medium comprising azide and amine. The azide can be selected from the group consisting of sodium azide and potassium azide or a combination of the two. The composition provides an effective pesticide, without causing significant harm to the environment. The composition may be applied to soil to control a population of a deleterious organism.Type: GrantFiled: October 8, 2002Date of Patent: August 23, 2005Assignee: Auburn UniversityInventor: Rodrigo Rodriguez-Kabana
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Patent number: 6818656Abstract: A method and composition for treating irritable bowel syndrome in a subject in need of such treatment, utilizing an amount of a polyamine having the formula: 1) R—NH—(CH2)a—NH—(CH2)bH—(CH2)c—NH2, 2) CF3—C6H5—(CH2)a—NH—(CH2)b—NH—(CH2)c—NH—(CH2)d—NH—(CH2)e—C6H5—CF3, 3) R—NH—(CH2)a—NH—C6H6—NH—(CH2)b—NH—R and 4) PIP—(CH2)aNH—(CH2)b—NH—(CH2)c—PIP, wherein: R is alkyl, aryl, aralkyl, alkaryl, or cyclo-alkyl having up to about 10 carbon atoms, and any of the alkyl chains may optionally be interrupted by at least one etheric oxygen atom, PIP is piperidine and a, b, c, d, and e may be the same or different and are integers from 1-10 effective to treat irritable bowel syndrome.Type: GrantFiled: September 30, 2003Date of Patent: November 16, 2004Assignee: University of FloridaInventor: Raymond J. Bergeron, Jr.
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Patent number: 6685953Abstract: The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): (wherein, R1 represents a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted by one or more hydroxy and/or alkoxy groups, R2 represents a linear or branched divalent hydrocarbon group having 1 to 12 carbon atoms, and R3 represents a linear or branched divalent hydrocarbon group having 1 to 42 carbon atoms). This diamide derivative (1) is capable of fundamentally improving the water retention capacity and barrier functions of the horny layer, is excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.Type: GrantFiled: October 4, 2001Date of Patent: February 3, 2004Assignee: Kao CorporationInventors: Masahide Hoshino, Yoshiya Sugai, Akiyo Kameyama, Hiroaki Saito, Yoshinori Nishizawa, Yutaka Takagi
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Patent number: 6673360Abstract: A preferred emulsifier blend includes ethoxylated alcohols containing hydrocarbons of C10-C16 and preferably having on average at least 2.8 ethoxy and/or alcohol groups per chain and a glycerol mono- and/or dioleates, preferably in a ratio of from 9:1 to 4:6. These emulsion blends are particularly useful when mixed with hydroisomerized oils and water, for subsequent application as a spray oil to agricultural crops. The emulsion blends of the present invention also find particular utility when mixed with conventional spray oils and hard water.Type: GrantFiled: January 29, 2003Date of Patent: January 6, 2004Assignees: Platte Chemical Company, Petro CanadaInventor: Michael Fefer
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Patent number: 6664270Abstract: A method and composition for treating irritable bowel syndrome in a subject in need of such treatment, utilizing an amount of a polyamine having the formula: RNH—(CH2)aNH(CH2)bNH(CH2)cNH2, 1) CF3—C6H5—(CH2)a—NH—(CH2)b—NH—(CH2)c—NH—(CH2)d—NH—(CH2)e—C6H5—CF3, 2) R—NH—(CH2)a—NH—C6H6—NH—(CH2)b—NH—R and 3) PIP—(CH2)aNH—(CH2)b—NH—(CH2)c—PIP, 4) wherein: R is alkyl, aryl, aralkyl, alkaryl, or cyclo-alkyl having up to about 10 carbon atoms, and any of the alkyl chains may optionally be interrupted by at least one etheric oxygen atom, PIP is piperidine and a, b, c, d, and e may be the same or different and are integers from 1-10 effective to treat irritable bowel syndrome.Type: GrantFiled: August 1, 2002Date of Patent: December 16, 2003Assignee: University of FloridaInventor: Raymond J. Bergeron, Jr.
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Patent number: 6623724Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diodls and/or triols and their analogues.Type: GrantFiled: May 28, 1998Date of Patent: September 23, 2003Assignee: Applied Genetics Incorporated DermaticsInventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
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Patent number: 6610652Abstract: Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (½ to {fraction (1/20)}) of those known to induce vasodilation in “normal” circulations.Type: GrantFiled: March 8, 2002Date of Patent: August 26, 2003Assignee: Queen's University at KingstonInventors: Michael A. Adams, Jeremy P. W. Heaton, James D. Banting
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Publication number: 20030069315Abstract: Use of a compound of formula I 1Type: ApplicationFiled: September 30, 2002Publication date: April 10, 2003Inventors: Sylvain Cottens, Robert Paul Hof, Roland Wenger
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Patent number: 6492560Abstract: The present invention provides discrete-length polyethylene glycol and polyethylene glycol containing compounds and methods for their preparation.Type: GrantFiled: September 24, 2001Date of Patent: December 10, 2002Assignee: The University of WashingtonInventors: D. Scott Wilbur, Pradip M. Pathare
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Patent number: 6458795Abstract: A method and composition for treating irritable bowel syndrome in a subject in need of such treatment, utilizing an amount of a polyamine having the formula: R—NH—(CH2)a—NH—(CH2)bH—(CH2)c—NH2, 1) CF3—C6H5—(CH2)a—NH—(CH2)b—NH—(CH2)c—NH—(CH2)dNH—(CH2)e—C6H5—CF3, 2) R—NH—(CH2)a—NH—C6H6—NH—(CH2)b—NH—R 3) and PIP—(CH2)a—NH—(CH2)b—NH—(CH2)c—PIP, 4) wherein: R is alkyl, aryl, aralkyl, alkaryl, or cyclo-alkyl having up to about 10 carbon atoms, and any of the alkyl chains may optionally be interrupted by at least one etheric oxygen atom, PIP is piperidine and a, b, c, d, and e may be the same or different and are integers from 1-10 effective to treat irritable bowel syndrome.Type: GrantFiled: November 15, 2001Date of Patent: October 1, 2002Assignee: University of FloridaInventor: Raymond J. Bergeron, Jr.
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Patent number: 6423683Abstract: Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (½ to {fraction (1/20)}) of those known to induce vasodilation in “normal” circulations.Type: GrantFiled: July 11, 2000Date of Patent: July 23, 2002Assignee: Queens University at KingstonInventors: Jeremy P. W. Heaton, Michael A. Adams, James D. Banting
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Publication number: 20020064520Abstract: The invention provides improved vectors for cell-specific gene delivery to a target cell. The vectors according to the instant invention comprise a recombinant core containing the genetic materials to be delivered and an artificially reconstituted surface encompassing the core. The surface facilitates targeting and cell fusion of the vector, and also provides an immunoprotection function for the vector. Methods for preparing the sectors and for transfecting eukaryotic cells using the vectors also are disclosed.Type: ApplicationFiled: August 19, 1999Publication date: May 30, 2002Inventors: YANINA ROZENBERG, VIACHESLAV MEDVEDKIN, W. FRENCH ANDERSON
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Publication number: 20010056124Abstract: Use of a compound of formula I 1Type: ApplicationFiled: July 3, 2001Publication date: December 27, 2001Inventors: Sylvain Cottens, Robert P. Hof, Roland Wenger
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Patent number: 6294697Abstract: The present invention provides discrete-length polyethylene glycol and polyethylene glycol containing compounds and methods for their preparation.Type: GrantFiled: April 17, 1998Date of Patent: September 25, 2001Assignee: The University of WashingtonInventors: D. Scott Wilbur, Pradip M. Pathare
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Patent number: 6290937Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.Type: GrantFiled: May 28, 1998Date of Patent: September 18, 2001Assignee: Applied Genetics Incorporated DermaticsInventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
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Patent number: 6277891Abstract: Nitric oxide generating compounds or compounds which induce in situ synthesis of nitric oxide can be used to inhibit rhinovirus infection. Nitric oxide has the ability to inhibit both viral replication as well as the synthesis of cytokines, in particular the proinflammatory cytokines. Thus the symptoms of rhinovirus infections can be ameliorated by treatments to increase nitric oxide in the respiratory tract.Type: GrantFiled: July 10, 1998Date of Patent: August 21, 2001Assignee: The Johns Hopkins UniversityInventors: Scherer P. Sanders, David Proud
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Patent number: 6274630Abstract: A method and pharmaceutical composition for inhibiting or preventing the intracellular biosynthesis of EIf5A by the administration to a human or non-human mammal in need thereof an amount of a polyamine analogue or salt thereof sufficient to deplete the supply of intracellular spermidine required for EIf5A biosynthesis.Type: GrantFiled: September 12, 1997Date of Patent: August 14, 2001Assignee: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, Jr.
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Patent number: 6190733Abstract: This invention provides water-based compositions, particularly coating, ink, and agricultural compositions, manifesting reduced equilibrium and dynamic surface tension by the incorporation of a surface tension reducing amount of certain alkylated aminoether compounds of the structure R—HN(CH2)p[O(CH2)n]mO(CH2)qNH—R′ where n is 2-6, m is 0-4, and p and q are 2-6, and R and R′ independently are an alkyl group comprising 5 to 18 carbons, preferably which is branched or in which the point of attachment to nitrogen is on a nonterminal carbon.Type: GrantFiled: June 7, 1999Date of Patent: February 20, 2001Assignee: Air Products and Chemicals, Inc.Inventors: Kevin Rodney Lassila, Kristen Elaine Minnich, Richard Van Court Carr
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Patent number: 6165975Abstract: A method of treatment, in an organism, of a vascular condition, comprising administration of at least one agent at a level which enhances NO and which does not appreciably alter normal systemic vascular tone in said organism. At least one agent is an NO donor selected from the group consisting of glyceryl trinitrate, isosorbide 5-mononitrate, isosorbide dinitrate, pentaerythritol tetranitrate, erythrityl tetranitrate, sodium nitroprusside, 3-morpholinosydnonimine molsidomine, S-nitroso-N-acetylpenicillamine, S-nitrosoglutathione, and N-hydroxy-L-arginine.Type: GrantFiled: December 22, 1999Date of Patent: December 26, 2000Assignee: Queen's University at KingstonInventors: Michael A. Adams, Jeremy P. W. Heaton, James D. Banting
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Patent number: 6103768Abstract: The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.Type: GrantFiled: September 8, 1997Date of Patent: August 15, 2000Assignee: Mycogen CorporationInventors: Steven D. Savage, Steven L. Evans, Robert A. Haygood, Paul S. Zorner, Keith Jones