Bicyclo Patents (Class 514/681)
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Patent number: 5439936Abstract: A therapeutic method is provided to inhibit tumor cell growth in a subject in need of said therapy is provided, comprising parenterally administering a therapeutic amount of a compound in a pharmaceutically acceptable carrier, wherein said compound has the structure: ##STR1## wherein R is selected from the group consisting of: ##STR2## and wherein said tumor cell is sensitive to inhibition by said compound and is selected from the group consisting of a myeloid leukemia cell, a T-cell leukemia cell, a lung carcinoma cell, an ovarian carcinoma cell, and a breast carcinoma cell.Type: GrantFiled: February 9, 1993Date of Patent: August 8, 1995Assignee: The Regents of the University of CaliforniaInventors: Michael J. Kelner, Trevor C. McMorris, Raymond Taetle
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Patent number: 5416114Abstract: A composition of matter which consists of (a) from about 13.0 to about 27.5% by weight of at least one compound selected from the group consisting of linolenic acid and derivatives thereof, calculated as the free acid, said derivatives or linolenic acid being both physiologically hydrolyzable and pharmacologically acceptable, and (b) about 87.0 to about 72.5% by weight of at least one compound selected from the group consisting of linoleic acid and derivatives thereof, calculated as the free acid, said derivatives of linoleic acid being both physiologically hydrolyzable and pharmacologically acceptable, is utilized e.g. as a pharmaceutical formulation or nutritional composition, in absence of an oily carrier or diluent which comprises at least one member of the group consisting of C.sub.Type: GrantFiled: July 20, 1993Date of Patent: May 16, 1995Assignee: Bar Ilan UniversityInventor: Shlomo Yehuda
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Patent number: 5393785Abstract: Novel antiestrogenic compounds are disclosed for use in therapeutic preparations for treatment of estrogen-dependent diseases. The compounds are specified diphenylethane and diphenylethylene analogs which show strong affinity for estrogen receptors but substantially lack the capacity to activate such receptors or otherwise act as agonists.Type: GrantFiled: July 14, 1992Date of Patent: February 28, 1995Assignee: Endorecherche, Inc.Inventors: Fernand Labrie, Yves Merand
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Patent number: 5374654Abstract: The invention relates to carbacyclin derivatives of Formula I ##STR1## wherein the various substituents are defined herein, including, inter alia,if R.sub.2 is a hydrogen atom, their salts with physiologically compatible bases, their cyclodextrin clathrates, and their use as medicinal agents.Type: GrantFiled: April 21, 1993Date of Patent: December 20, 1994Assignee: Schering AktiengesellschaftInventors: Helmut Vorbruggen, Ulrich Klar, Bob Nieuweboer, Claus-Steffen Sturzebecher
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Patent number: 5350773Abstract: Disclosed are stable liquid products as consisting essentially ofat least one finely dispersed physiologically tolerated fat-soluble substance as disperse phase;glycerol or glycerol mixed with water as continuous phase; andesters of ascorbic acid with long-chain fatty acids as an emulsifier and stabilizer.Type: GrantFiled: January 8, 1993Date of Patent: September 27, 1994Assignee: BASF AktiengesellschaftInventors: Loni Schweikert, Clemens Sambale
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Patent number: 5314914Abstract: A group of known naphthoquinone derivatives have been found to be useful for preventing or relieving herpes viral infections.Type: GrantFiled: February 19, 1992Date of Patent: May 24, 1994Assignee: BioMega/Boehringer Ingelheim Research Inc.Inventor: Yvan Guindon
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Patent number: 5294613Abstract: This invention provides benzene derivatives, pharmaceutical formulations of those derivatives, and a method of using the derivatives for the treatment of inflammation in mammals.Type: GrantFiled: February 7, 1992Date of Patent: March 15, 1994Assignee: Eli Lilly and CompanyInventors: Nancy G. Bollinger, Theodore Goodson, Jr., David K. Herron
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Patent number: 5288752Abstract: A compound having the formula (I): ##STR1## wherein A is --CH.sub.2 --, R.sup.1 is CH.sub.3 or OCH.sub.3 ; R.sup.2 is hydroxy or carboxy, carboxylic acid or carboxylic acid ester group; R.sup.3 is H or a lower alkyl; and n is 0 or an integer of 1 to 6 or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 23, 1992Date of Patent: February 22, 1994Assignee: Suntory LimitedInventors: Toshio Tatsuoka, Kenji Suzuki, Fumio Satoh, Seiji Miyano, Kunihiro Sumoto
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Patent number: 5248668Abstract: Purpurogallin and its mono- and di-glucosides are useful as cytoprotective agents. Patient-administrable compositions for addition to a patient's blood to minimize oxyradical damage caused by ischemia-reperfusion injury that may result in various surgical procedures, and comprising purpurogallin or glucosides thereof, and uses thereof, are described.Type: GrantFiled: September 28, 1992Date of Patent: September 28, 1993Assignee: Wintek Consulting Ltd.Inventor: Tai W. Wu
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Patent number: 5232915Abstract: 9.alpha.-Hydroxy-19,11.beta.-bridged steroids of general formula I ##STR1## are described. The more detailed meaning of A, B, R.sup.1, R.sup.2, G, Z, R.sup.4 --Y and R.sup.4' --Y' follows from the description. The steroids of general formula I have antigestagen and/or antiglucocorticoidal action and can be used for the production of pharmaceutical agents.Type: GrantFiled: January 14, 1992Date of Patent: August 3, 1993Assignee: Schering AktiengesellschaftInventors: Eckhard Ottow, Gunter Neef, Rudolf Wiechert, Walter Elger, Sybille Beier, Karl-Heinrich Fritzemeier
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Patent number: 5223264Abstract: The present invention relates to oral effervescent dosage forms for the administrations of an intended ingredient to children, and processes for their administration.Type: GrantFiled: August 26, 1991Date of Patent: June 29, 1993Assignee: Cima Labs, Inc.Inventors: Fred Wehling, Steve Schuehle, Navayanarao Madamala
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Patent number: 5180747Abstract: Stabilized fat-soluble vitamin compositions are disclosed which comprise fat-soluble vitamins and carotenoids as a stabilizer. They are stable to light and have a wide range of applications such as medicines, veterinary medicines, food additives, feed additives, nutrient supplements or the like.Type: GrantFiled: May 21, 1992Date of Patent: January 19, 1993Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Yoshihisa Matsuda, Reiko Teroaka, Yukio Tanaka, Hisato Abe
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Patent number: 5162377Abstract: A transparent composition containing a phospholipid, at least one cationic or nonionic surfactant, an oily component, and water.Type: GrantFiled: June 15, 1989Date of Patent: November 10, 1992Assignee: Shiseido Company, Ltd.Inventors: Hiroyuki Kakoki, Shoji Nishiyama, Michihiro Yamaguchi, Yoshimaru Kumano
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Patent number: 5162353Abstract: The invention relates to carbacyclin derivatives with general formula I: ##STR1## in which Y.sub.1 stands for the radical --CH.sub.2 --X--(CH.sub.2).sub.n --R.sub.1 or the radical ##STR2## n, 1 or 3, R.sub.1, the radical ##STR3## the radical ##STR4## R.sub.9 stands for the radical --(CH.sub.2).sub.m --R.sub.6 or the radical --(CH.sub.2).sub.m-o --[Z.sub.1 --(CH.sub.2).sub.m-p ].sub.x --[Z.sub.2 --(CH.sub.2).sub.m-q ].sub.y --R.sub.6,m=2-20,o, p, and q are less than or equal to 19,x, y=0, 1 or 2,Z.sub.1 stands for a cis--CH.dbd.CH group, a trans--CH.dbd.CH group of a --C.dbd.C group, and each of these groups must be separated at least by a methylene group from the C-9 carbon atom of the carbacyclin bicyclic compound,Z.sub.2 stands for oxygen, sulfur, an NH or an N methyl group,R.sub.6 stands for amino, methylamino, hydroxy, carboxy or mercapto,X an oxygen atom or a methylene group,Y.sub.2 hydrogen or fluorine,A a --CH.sub.2 --CH.sub.2, trans--CH.dbd.CH or --C.dbd.Type: GrantFiled: August 21, 1990Date of Patent: November 10, 1992Assignee: Schering AktiengesellschaftInventors: Helmut Vorbrueggen, Bob Nieuweboer, Claus-Steffen Stuerzebecher
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Patent number: 5141937Abstract: Pharmaceutical products containing a 7-diphenylmethylenebicycloheptane or 7-diphenylmethylenebicycloheptene derivative of the formula I ##STR1## in which A, B, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the stated meanings, or a physiologically tolerated acid addition salt of these compounds, and the use thereof as hypolipidemics are described. In addition, new 7-diphenylmethylenebicycloheptane and -heptene derivatives of the formula Ia ##STR2## in which A, B, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the stated meanings, and the physiologically tolerated acid addition salts thereof, as well as processes for the preparation thereof, are described.Type: GrantFiled: September 21, 1988Date of Patent: August 25, 1992Assignee: Hoechst AktiengesellschaftInventors: Herbert Siegel, Ernold Granzer
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Patent number: 5128151Abstract: Powdered and/or granulated menadione sodium bisulfite formulations additionally contain a physiologically tolerated organic or inorganic acid.The novel formulations possess good water solubility and stability.Type: GrantFiled: January 7, 1988Date of Patent: July 7, 1992Assignee: Basf AktiengesellschaftInventors: Hans Kiefer, Wolfgang Buehler, Joachim U. Schneider, Hagen Jaedicke
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Patent number: 5126371Abstract: Novel diarylacetylenes of the formula I ##STR1## where A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 have the meanings stated in the description, are useful for the treatment of disorders.Type: GrantFiled: August 20, 1990Date of Patent: June 30, 1992Assignee: BASF AkteingesellschaftInventors: Hans-Heiner Wuest, Fritz-Frieder Frickel, Axel Nuerrenbach
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Patent number: 5106407Abstract: The present invention discloses the antimicrobial utility of certain iodonium ylide compounds. The particular iodonium ylide compounds are phenyl iodonium ylides having an ortho substituent that stabilizes the positive charge on the polyvalent iodine by a nonbonded electrostatic interaction. The polyvalent iodine is further stabilized by a cyclic 1,3-dicarbonyl anion.Type: GrantFiled: December 4, 1989Date of Patent: April 21, 1992Assignee: The Dow Chemical CompanyInventors: Attila G. Relenyi, Gerald F. Koser, Richard W. Walter, Jr., William J. Kruper, Jr., Ravi B. Shankar, Anthony P. Zelinko
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Patent number: 5023271Abstract: A method for parenteral administration of fat-soluble pharmaceuticals and vitamins using microemulsions is disclosed. The microemulsions are comprised of a naturally occurring amphipatic substance and a hydrophobic lipid along with the active ingredient, are size selected for 300-1000 .ANG. pseudomicelles, and permit safe intravenous injection of the active ingredient. Levels of the active ingredient in the various lipoprotein fractions of serum appear to mimic the natural distribution of the administered drug if taken orally.Type: GrantFiled: August 13, 1985Date of Patent: June 11, 1991Assignee: California Biotechnology Inc.Inventors: Jean-Louis Vigne, John P. Kane
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Patent number: 5021570Abstract: An aqueous solution containing fat-soluble vitamin K is prepared by adding vegetable oil(s), gycerol fatty acid ester(s) or sorbitan fatty acid ester(s) in an amount of 0.004 to 5% by weight, based on the whole aqueous solution, to an aqueous solution containing menatetrenone (vitamin K.sub.2) or phytonadione (vitamin K.sub.1) and hydrogenated lecithin.Type: GrantFiled: July 7, 1989Date of Patent: June 4, 1991Assignee: Eisai Co., Ltd.Inventors: Katsumi Ida, Takayuki Ikeuchi, Masanori Kayano
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Patent number: 5000961Abstract: The invention relates to benzylidenecamphor derivatives of formula: ##STR1## where R is hydrogen or a tert-butyl residue, R.sub.1 is a C.sub.1 -C.sub.8 alkyl or alkoxy residue, and R.sub.2 and R.sub.3 denote hydrogen or hydroxyl, at least one of the two being hydroxyl, to a process for preparing them and to their uses as antioxidants, broad-band sunscreens and medicinal products for the preventive treatment of skin allergies and inflammations as well as for the prevention of certain cancers.Type: GrantFiled: May 23, 1990Date of Patent: March 19, 1991Assignee: L'OrealInventors: Gerard Lang, Serge Forestier, Alain Lagrange, Claudine Moire, Andre Deflandre
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Patent number: 4971987Abstract: The invention also relates to carbacyclin derivatives of general formula I' ##STR1## wherein R.sub.9 is an alkyl group of 1-10 carbon atoms or the group --C.dbd.C--(CH.sub.2).sub.m --R.sub.6 whereinm is 1 to 16 andR.sub.6 is hydroxy on amino.Type: GrantFiled: March 7, 1988Date of Patent: November 20, 1990Assignee: Schering AktiengesellschaftInventors: Helmut Vorbrueggen, Bob Nieuweboer, Claus-Steffen Stuerzebecher, Ulrich Klar
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Patent number: 4952391Abstract: New tert-butyl derivatives of benzylidenecamphor, process for preparing them, their use as antioxidant agents and cosmetic and pharmaceutical compositions containing them.The invention relates to benzylidenecamphor derivatives of formula: ##STR1## where R is hydrogen or a tert-butyl residue, R.sub.1 is a C.sub.1 -C.sub.8 alkyl or alkoxy residue, and R.sub.2 and R.sub.3 denote hydrogen or hydroxyl, at least one of the two being hydroxyl, to a process for preparing them and to their uses as antioxidants, broad-band sunscreens and medicinal products for the preventive treatment of skin allergies and inflammations as well as for the prevention of certain cancers.Type: GrantFiled: October 5, 1988Date of Patent: August 28, 1990Assignee: L'OrealInventors: Gerard Lang, Serge Forestter, Alain LaGrange, Claudine Moire, Andre DeFlandre
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Patent number: 4840970Abstract: Disclosed herein is an aqueous solution containing a lipid-soluble active vitamin substance and/or ubiquinone. The solution has a pH of 5.5-8 and additionally contains a hydrogenated lecithin and neutral amino acid. It is stable and free from side effects, and is rather easy to prepare.Type: GrantFiled: June 1, 1987Date of Patent: June 20, 1989Assignee: Eisai Co., Ltd.Inventors: Hiroyuki Ohasi, Toru Takami, Noritoshi Koyama, Yoshio Kogure, Katsumi Ida, Kazumi Iijima, Tomohiro Kobori
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Patent number: 4815923Abstract: A rodenticide includes an active ingredient mixed with an inert ingredient comprising dried sweet corn as a substantial portion thereof. The dried sweet corn is preferably ground, mixed with the active ingredient and pelleted, resulting in a safe yet effective rodenticide.Type: GrantFiled: September 22, 1986Date of Patent: March 28, 1989Assignee: Sweet Corn ProductsInventor: Raymon W. Lush
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Patent number: 4816490Abstract: A method of reducing hyperlipemia in warm-blooded animals by administration of an effective amount of 2-[(3,4-dimethoxy-benzoyl)-methyl]-2-hydroxy-1,3-dioxoIndone.Type: GrantFiled: December 17, 1987Date of Patent: March 28, 1989Assignee: Jouveinal S.A.Inventor: Guy Petibon
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Patent number: 4804535Abstract: Disclosed are aqueous multivitamin/trace elements formulations stabilized by a water soluble, organic acid that contains carbon-to-carbon unsaturation and water soluble salts thereof selected from the group consisting of maleic acid, fumaric acid, maleamic acid and acrylic acid.Type: GrantFiled: February 8, 1988Date of Patent: February 14, 1989Assignee: Rorer Pharmaceutical CorporationInventors: Morris Kesselman, Abdur R. Purkaystha, James Cahill
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Patent number: 4791123Abstract: There are provided new alkane and alkoxyalkane derivatives of the general formula I ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4 and A have the meanings given in the description, processes for their preparation and insecticidal and acaricidal compositions containing these compounds.Type: GrantFiled: January 22, 1987Date of Patent: December 13, 1988Assignee: Schering Akt.Inventors: Helga Franke, Heinrich Franke, Hans-Rudolf Kruger, Hartmut Joppien, Dietrich Baumert, David Giles
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Patent number: 4751240Abstract: A phenol derivative of the formulaNU--A--X--R.sup.1wherein NU is a defined phenolic nucleus including a phenyl-hydroxynaphthyl; hydroxyphenyl-naphthyl; phenyl-hydroxyindanyl, phenyl-hydroxybenzothienyl or mono-hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages, wherein R.sup.1 is hydrogen, or alkyl, alkenyl, alkynyl, cycloalkyl, halogenoalkyl, alkoxyalkyl, halogenoalkoxyalkyl, aryl or arylalkyl, or R.sup.1 is joined to R.sup.2, and wherein X is --CONR.sup.2 --, --CSNR.sup.2 --, --NR.sup.12 CO--, --NR.sup.12 CS--, --NR.sup.12 CONR.sup.2 --, ##STR1## --SO.sub.2 NR.sup.2 --or --CO--, or, when R.sup.1 is not hydrogen, is --NR.sup.12 COO--, --(PO)R.sup.2 13 , --S--, --SO--or --SO.sub.2 --, wherein R.sup.2 is hydrogen or alkyl, or R.sup.1 and R.sup.2 together form alkylene; wherein R.sup.12 is hydrogen or alkyl, and wherein R.sup.22 is hydrogen, cyano or nitro; or a salt thereof when appropriate.Type: GrantFiled: April 24, 1985Date of Patent: June 14, 1988Assignee: Imperial Chemical Industries PLCInventors: Jean Bowler, Graham C. Crawley, Philip N. Edwards, Alasdair T. Glen, Michael S. Large, Brian S. Tait
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Patent number: 4740373Abstract: Disclosed are aqueous multivitamin/trace elements formulations stabilized by a water soluble, organic acid that contains carbon-to-carbon unsaturation and water soluble salts thereof selected from the group consisting of maleic acid, fumaric acid, maleamic acid and acrylic acid.Type: GrantFiled: May 27, 1986Date of Patent: April 26, 1988Assignee: USV Pharmaceutical CorporationInventors: Morris Kesselman, Abdur R. Purkaystha, James Cahill
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Patent number: 4735969Abstract: A novel bisulfite adduct of menadione, the menadione choline bisulfite adduct, a process for its preparation, and its use as an antihemorrhagic agent.Type: GrantFiled: November 18, 1985Date of Patent: April 5, 1988Assignee: BASF AktiengesellschaftInventors: Joachim U. Schneider, Hans Kiefer
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Patent number: 4734282Abstract: A food composition for poisoning a rodent, which comprises a rodent foodstuff which contains as an active rodenticidal agent, a lethal or sub-lethal quantity of a compound having the formula: ##STR1## wherein X is Cl, Br, F, or I; Y is H, Cl, Br, F, I, --SO.sub.3 H, SO.sub.3 Na, or --SO.sub.3 K; and R.sub.1 -R.sub.4 are each independently H, Cl, Br, F, I, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxyl, or C.sub.1 -C.sub.6 alkoxyalkyl or a hydroquinone analogue of the compound, and a method for controlling rodents using said composition.Type: GrantFiled: April 23, 1986Date of Patent: March 29, 1988Assignee: Duke UniversityInventors: Thorir D. Bjornsson, David M. Cocchetto
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Patent number: 4670247Abstract: A process is described for the preparation of fat-soluble vitamin active beadlet compositions which exhibit superior stability when exposed to the feed pelleting process. The process includes forming an aqueous emulsion of a fat-soluble vitamin-active material, gelatin, and a sugar converting the emulsion to dry particulate form containing the non-aqueous constituents of the emulsion and heat treating the resulting product to form water insoluble beadlets.Type: GrantFiled: March 24, 1986Date of Patent: June 2, 1987Assignee: Hoffman-LaRoche Inc.Inventor: Leonard J. Scialpi
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Patent number: 4656192Abstract: New tropolone derivatives of the general formula: ##STR1## wherein R.sup.1 represents H or an alkyl group, R.sup.2 represents an alkyl, aryl, aralkyl or heterocyclic group and R.sup.3 represents an alkoxyl, aryl or heterocyclic group or a group of the formula: ##STR2## or R.sup.2 and R.sup.3 may form together a part of a heterocyclic group, their metal complex salts, processes for the preparation thereof and the use thereof as anti-tumor agents.Type: GrantFiled: June 14, 1984Date of Patent: April 7, 1987Assignee: Mect CorporationInventor: Masatoshi Yamato
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Patent number: 4613611Abstract: A method of treating diabetes mellitus using arylglyoxals which are known compounds.Type: GrantFiled: October 14, 1983Date of Patent: September 23, 1986Assignee: American Cyanamid CompanyInventors: Middleton B. Floyd, Jr., Jo A. Goidl
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Patent number: 4581378Abstract: This application discloses rodenticide compositions containing artificial sweeteners. The disclosed compositions have improved acceptability to the rodents and longer storage life.Type: GrantFiled: February 10, 1982Date of Patent: April 8, 1986Assignee: United Agri Products, Inc.Inventors: Remus Lazar, Emil P. Lira
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Patent number: 4569945Abstract: The invention is dealing with arylindane-1,3-diones of the formula: ##STR1## which can be used in the treatment of inflammatories, psoriasis and asthma.Type: GrantFiled: October 12, 1984Date of Patent: February 11, 1986Assignee: Akzo N.V.Inventors: Alexander C. Campbell, Donald F. M. Stevenson
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Patent number: 4525341Abstract: A method for administering vitamins to an air-breathing animal consists of introducing the vitaminic aerosol containing a breath freshener into the nose or mouth opening of the animal.Type: GrantFiled: April 9, 1984Date of Patent: June 25, 1985Assignee: Mayor Pharmaceutical Laboratories, Inc.Inventor: Joseph A. Deihl
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Patent number: H852Abstract: A method for stabilizing a rodenticidally active material selected from certain (i) indane dione derivatives, (ii) hydroxycoumarin derivatives and (iii) thiocoumarin analogs of (ii), comprising bringing said active material into contact with, and maintaining the active material in contact with, an acidic stabilizer.Type: GrantFiled: October 27, 1988Date of Patent: November 6, 1990Assignee: E. I. Du Pont de Nemours and Company, Inc.Inventors: Alan R. Garden, Malcolm R. Hadler