C=o Bonded Directly To Benzene Ring Patents (Class 514/685)
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Publication number: 20100267838Abstract: The present invention relates to pulverulent compositions of at least one carotenoid selected from the group consisting of ?-carotene, astaxanthin, canthaxanthin, citranaxanthin, lycopene and lutein, a process for the production of these pulverulent compositions, and the use of the pulverulent compositions.Type: ApplicationFiled: November 11, 2008Publication date: October 21, 2010Applicant: BASF SEInventor: Christian Köpsel
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Publication number: 20100261763Abstract: The present invention relates generally to compounds providing antibacterial therapeutic agents and preparations, and related methods of using and making antibacterial compounds. Antibacterial compounds of the present invention include chalcone, alkylpyrimidine, aminopyrimidine and cyanopyridine compounds and derivatives thereof exhibiting minimum inhibitory concentrations (MIC) similar to or less than conventional antibacterial compounds in wide use. For example, the present invention provides chalcone and cyanopyridine compounds, and derivatives thereof, exhibiting high antibacterial activities having multiple electron withdrawing group substituents, such as halogens and fluorinated alky groups, and optionally having hydroxyl and/or alkoxyl groups substituents.Type: ApplicationFiled: June 14, 2010Publication date: October 14, 2010Inventors: Helen E. BLACKWELL, Matthew D. BOWMAN, Jennifer C. O'NEILL, Joseph R. STRINGER
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Publication number: 20100254925Abstract: Antimicrobially active 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone of the following formula 1 is described, as is a method for producing this compound and the use thereof as an antimicrobial active ingredient.Type: ApplicationFiled: July 14, 2008Publication date: October 7, 2010Applicant: SYMRISE GMBH & Co. KGInventors: Oskar Koch, Gerhard Schmaus
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Publication number: 20100249243Abstract: This invention relates to ?-hydroxyketones and ?-alkoxyketones of formula (I), to their use as estrogen receptor modulators, and to methods for their preparation.Type: ApplicationFiled: November 21, 2008Publication date: September 30, 2010Inventors: Juha Pulkkinen, Paavo Honkakoski, Mikael Peräkylä, Istvan Berczi, Reino Laatikainen
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Patent number: 7799955Abstract: There are disclosed compounds of formulae (I) or (II) in which A is selected from the group consisting of (1), (2), (3) and (4); OH, and one of R1 and R2 is selected from H, OH and OCH3, and the other of R1 and R2 is selected from OH and OCH3; one of R3 and R4 is selected from H, OH and OCH3, and the other of R3 and R4 is selected from OH and OCH3; provided that at least one of the pairs R1, R2 and R3, R4 are both OH; R5 is selected from OH and OCH3; and denotes a single or double bond; and pharmaceutically acceptable salts and prodrugs thereof. The compounds of the invention are useful for the treatment of hormone-dependent conditions and cancers.Type: GrantFiled: March 30, 2009Date of Patent: September 21, 2010Inventor: George Eustace Joannou
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Patent number: 7799763Abstract: A muscle-strengthening, anti-inflammatory, antiasthmatic, antidiarrheal or an antidepressant method, or a method for the treatment of diminution of vision, hepatitis, inflammatory intestinal syndrome, functional enteropathy, functional hepatopathy, functional nephropathy, dementia, climacteric symptoms, senile dementia and/or Alzheimer disease, said method comprising: administering to skin a composition comprising (a) at least one member selected from the group consisting of isoflavones and isoflavone glycosides, (b) curcumin, and (c) cholic acid or at least one member selected from the group consisting of scymnol and scymnol esters.Type: GrantFiled: December 21, 2006Date of Patent: September 21, 2010Assignee: Daicho Kikaku Incorporated CompanyInventors: Kenkichi Okada, Akio Ochiai, Masaki Kosuge, Takao Daicho, Kuniro Tsuji, Haruo Nukaya, Oto Miura
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Publication number: 20100227009Abstract: The present invention is directed to pest-controlling compositions comprising as active ingredients one or more ?-diones, particularly ?-diketones and ?-triketones, and to the use of these compositions inter alia for preventing, eradicating, destroying, repelling or mitigating harmful, annoying or undesired pests including insects, arachnids, helminths, molluscs, protozoa and viruses. The present invention is further directed to processes of preparing ?-diones by de novo synthesis or from natural sources such as volatile oil-bearing plants from families including Alliaceae, Apiaceae, Asteraceae, Cannabinaceae, Lamiaceae, Pteridaceae, Myrtaceae, Myoporaceae, Proteaceae, Rutaceae and Zingiberaceae.Type: ApplicationFiled: May 18, 2010Publication date: September 9, 2010Applicants: BIOPROSPECT LIMITED, UNIVERSITY OF WESTERN SYDNEYInventors: Robert Neil Spooner-Hart, Albert Habib Basta
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Publication number: 20100209382Abstract: Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.Type: ApplicationFiled: September 18, 2006Publication date: August 19, 2010Applicant: ORDWAY RESEARCH INSTITUTE, INC.Inventors: Maria Alexander-Bridges, Shaker A. Mousa, Paul J. Davis
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Patent number: 7767719Abstract: This invention relates compositions containing compounds of formula (I) below: Each of R1, R2, R3, R4, R5, R6, R7, and R8 is defined in the specification.Type: GrantFiled: April 9, 2007Date of Patent: August 3, 2010Assignee: SunTen Phytotech Co., Ltd.Inventors: Du-Shieng Chien, Yi-Wen Chu, Wu-Chang Chuang, Ming-Chung Lee
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Patent number: 7749990Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed.Type: GrantFiled: September 11, 2008Date of Patent: July 6, 2010Assignee: Wellstat Therapeutics CorporationInventors: Kirvin L. Hodge, Shalini Sharma, Reid W. von Borstel
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Patent number: 7745495Abstract: The invention relates to compounds of formula (I) wherein A1 is C(R1R2)p; A2 is C(R6R7)q; p is 1 or 2; q is 1 or 2; each of R1, R2, R3, R4, R5, R6, R7 and R8 which may be the same or different, represents hydrogen, methyl or ethyl and R9 is C1-C4alkyl; R10 is hydrogen, halogen, C1-C3alkyl or C1-C3-haloalkyl, and agronomically acceptable salts/isomers/enantiomers/tautomers/N-oxides of those compounds.Type: GrantFiled: December 20, 2005Date of Patent: June 29, 2010Assignee: Syngenta Crop Protection, Inc.Inventors: Sebastian Volker Wendeborn, Renaud Beaudegnies, Andrew Edmunds, Christoph Luthy, Jurgen Schaetzer
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Patent number: 7745424Abstract: The present invention pertains to certain alkane diol derivatives (including, e.g., mono- and di-esters) of the formula R1—O-A-O—R2, wherein: A is a C2-10 alkylene group; R1 is independently a first hydroxy protecting group (e.g., an ester group); and, R2 is independently —H or a second hydroxy protecting group (e.g., an ester group); and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrug thereof, which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption.Type: GrantFiled: October 31, 2002Date of Patent: June 29, 2010Assignee: The Univeristy Court of the University of AberdeenInventors: Stuart H Ralston, Iain R Greig, Robert J Van't Hof, Kenneth J Armour
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Publication number: 20100135900Abstract: The present disclosure provides methods for using CD37-specific binding molecules (such as a CD37-specific SMIP or antibody) in combination with mTOR inhibitors (such as rapamycin and derivatives or analogues thereof) or phosphatidylinositol 3-kinase (PI3K) inhibitors (such as p110?-specific inhibitors or the like), which can be done concurrently or sequentially, to treat or prevent a B-cell related hyperproliferative disease, such as a lymphoma, carcinoma, myeloma, or the like.Type: ApplicationFiled: November 13, 2009Publication date: June 3, 2010Applicant: TRUBION PHARMACEUTICALS, INC.Inventors: CHARLES G. CERVENY, PETER A. THOMPSON
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Publication number: 20100137449Abstract: Compounds and methods for multi-targeted protein kinase modulation for angiogenesis, cancer treatment or the inflammatory pathways associated with those conditions are disclosed. The compounds and methods disclosed are based on substituted 1,3-cyclopentadione compounds.Type: ApplicationFiled: December 10, 2008Publication date: June 3, 2010Applicant: METAPROTEOMICS, LLCInventors: Matthew L. Tripp, John G. Babish, Jeffrey S. Bland, Veera Konda, Anu Desai, Gary Darland, Brian J. Carroll, James S. Traub, Linda M. Pacioretty, Dennis Emma
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Publication number: 20100120903Abstract: An anti-inflammatory agent which includes an oil-soluble licorice extract, prepared by subjecting at least one of a leguminous plant of the genus Glycyrrhiza and a water extraction residue of a leguminous plant of the genus Glycyrrhiza to an extraction treatment with an organic solvent and which has at least one effect selected from an inhibitory effect on hyaluronidase activity, an inhibitory effect on hexosaminidase release (i.e., inhibitory effect on histamine release), an inhibitory effect on platelet aggregation, and an inhibitory effect on phospholipase A2 activity.Type: ApplicationFiled: January 15, 2010Publication date: May 13, 2010Inventors: Yasuo Miyake, Ito Yoko
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Patent number: 7714170Abstract: Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A? amyloidosis, such as observed in Alzheimer's disease, use in the reduction of A? peptide in vivo, use in modulating APP processing, and use in modulating the activity of APP secretase.Type: GrantFiled: December 8, 2008Date of Patent: May 11, 2010Assignee: Proteotech, Inc.Inventors: Alan D. Snow, Qubai Hu, Judy A. Cam
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Publication number: 20100099642Abstract: The invention relates to the use of TGF-beta stimulating agents, and in particular members of the triphenylethylene class of pharmaceutical agents, for the prevention, prophylaxis, treatment or amelioration of symptoms of cardiovascular disease, autoimmune diseases or neurodegeneration. In particular, improved compositions consisting of triphenylethylene agents combined with one or more additional active pharmaceutical agents in order to mitigate against side-effects of the triphenylethylene are described and claimed.Type: ApplicationFiled: February 7, 2008Publication date: April 22, 2010Applicant: TCP Innovations LimitedInventor: David J. Grainger
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Patent number: 7678946Abstract: Trisubstituted phenol compounds and methods of using the compounds, e.g., for anesthetizing a subject, are disclosed.Type: GrantFiled: July 13, 2007Date of Patent: March 16, 2010Assignee: University of Iowa Research FoundationInventor: Max T. Baker
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Publication number: 20100029757Abstract: The present invention relates to the use of xanthohumol with formula (I) as an agent for the production of a preparations for preventing and/or combating liver diseases.Type: ApplicationFiled: December 21, 2007Publication date: February 4, 2010Applicant: JOH. BARTH & SOHN GMBH & CO. KGInventor: Claus Hellerbrand
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Publication number: 20090312407Abstract: A compound, pharmaceutical composition and method for the treatment of mammals wherein the active therapeutic agent is a compound having the structure: wherein: R1 is an electronegative substituent, R2 is R1 or alkyl, R3 is H or O-alkyl, R4 and R5 are the same or different and are alkyl and R6 is H or OH.Type: ApplicationFiled: December 16, 2007Publication date: December 17, 2009Inventors: Kinfe Redda, Chavonda Janeebra Mills, Nelly Mateeva
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Patent number: 7632870Abstract: The invention concerns compositions comprising substituted 1,3-diphenylprop-2-en-1-one derivatives designed for therapeutic use. The inventive compositions are useful in particular for preventing or treating cardiovascular diseases, syndrome X, Ia restenosis, diabetes, obesity, hypertension, inflammatory diseases, cancers or neoplasms (benign or malignant tumors), neurodegenerative, dermatological diseases and disorders related to oxidative stress, for preventing or treating the effects of ageing in general and for example skin ageing, in particular in the field of cosmetics (occurrence of wrinkles and the like).Type: GrantFiled: July 8, 2003Date of Patent: December 15, 2009Assignee: GenfitInventors: Jamila Najib, Karine Caumont-Bertrand
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Publication number: 20090286874Abstract: An anti-aging composition containing: (a) at least one first active ingredient chosen from phloretin and its derivatives; (b) at least one second active ingredient chosen from cinnamic acid, resveratrol, retinol, ascorbic acid, tocopherol, and their derivatives; and (c) at least one non-aqueous organic solvent, with the proviso that if the composition contains ascorbic acid, water is present as a co-solvent.Type: ApplicationFiled: April 15, 2009Publication date: November 19, 2009Applicant: L'OREALInventors: Sheldon R. Pinnell, Jan Zielinski, Isabelle Hansenne
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Publication number: 20090258094Abstract: A method for preparing a xanthohumol-rich hop composition. The method includes providing a solution that contains xanthohumol-containing hop substances and effecting precipitation of non-xanthohumol hop substances by adjusting both the salt concentration and pH value of the solution. The xanthohumol-rich hop composition prepared by this method can be used for treating various diseases, e.g., skin disorders, and bacterial infection.Type: ApplicationFiled: April 10, 2009Publication date: October 15, 2009Applicant: Flaxan GmbH & Co. KGInventors: Mitsunori Ono, Naoto Yamaguchi, Keiko Yamaguchi
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Patent number: 7601876Abstract: Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A? amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.Type: GrantFiled: March 5, 2007Date of Patent: October 13, 2009Assignee: Proteotech, Inc.Inventors: Alan D. Snow, Beth P. Nguyen, Gerardo M. Castillo, Virginia J. Sanders, Thomas P. Lake, Lesley Larsen, Rex T. Weavers, Stephen D. Lorimer, David S. Larsen, David L. Coffen, Charlotte Coffen, legal representative
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Publication number: 20090252694Abstract: Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound.Type: ApplicationFiled: April 3, 2006Publication date: October 8, 2009Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSTIYInventors: Ki Hun Park, Jin Hyo Kim, Woo Duck Seo, Young Bae Ryu, Hyung Won Ryu, Woo Song Lee, Sang Wan Gal
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Patent number: 7598294Abstract: The present invention pertains to the use of a compounds for the manufacture of a medicament for use in the treatment of a proliferative condition, wherein the compounds have the following formula: wherein: each of RB2, RB3, RB4, and RB5 is independently —H, —OH, or —OMe; each of R1 and R2 is independently: —H, optionally substituted C1-4alkyl, or optionally substituted C5-20aryl; RA3 is —H, —OH, —OC(?O)RE, —OS(?O)2OH, or —OP(?O)(OH)2; RE is: —H, optionally substituted C1-6alkyl, optionally substituted C3-20 heterocyclyl, or optionally substituted C5-20aryl; or a pharmaceutically acceptable salt, solvate, amide, ester, ether, chemically protected form, or prodrug thereof. The present invention also pertains to such compounds, pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for both diagnosis and treatment of, for example, proliferative conditions, such as cancer, and inflammatory conditions.Type: GrantFiled: September 30, 2002Date of Patent: October 6, 2009Assignee: Spear Therapeutics LimitedInventors: Gerard A Potter, Paul C Butler
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Publication number: 20090232853Abstract: The present invention provides a composition comprising one or more of a matrix metalloprotease inhibitor, a de-carboxylase inhibitor, a fructanase enzyme and/or a flavonoid for use in the prevention of laminitisType: ApplicationFiled: March 21, 2006Publication date: September 17, 2009Inventor: Patricia Ann Harris
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Publication number: 20090209655Abstract: There are disclosed compounds of formulae (I) or (II) in which A is selected from the group consisting of (1), (2), (3) and (4); OH, and one of R1 and R2 is selected from H, OH and OCH3, and the other of R1 and R2 is selected from OH and OCH3; one of R3 and R4 is selected from H, OH and OCH3, and the other of R3 and R4 is selected from OH and OCH3; provided that at least one of the pairs R1, R2 and R3, R4 are both OH; R5 is selected from OH and OCH3; and denotes a single or double bond; and pharmaceutically acceptable salts and prodrugs thereof. The compounds of the invention are useful for the treatment of hormone-dependent conditions and cancers.Type: ApplicationFiled: March 30, 2009Publication date: August 20, 2009Applicant: G. J. CONSULTANTS PTY. LTD.Inventor: George Eustace Joannou
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Publication number: 20090209654Abstract: Methods and formulations for increasing the water solubility and/or bioavailability of prenylfiavonoids are disclosed. The formulations may be employed to treat a disease states, including cancer.Type: ApplicationFiled: July 31, 2006Publication date: August 20, 2009Inventor: Eric Kuhrts
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Publication number: 20090208434Abstract: The present invention concerns applications of the compound of formula 1 in cosmetic or pharmaceutical preparations.Type: ApplicationFiled: February 18, 2009Publication date: August 20, 2009Applicant: SYMRISE GmbH & Co. KGInventors: Gerhard Schmaus, Oskar Koch
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Publication number: 20090202464Abstract: A method of providing a fragrant odour to an application, comprising the addition thereto of at least one compound of the formula (I) wherein X and Y are independently selected from the group consisting of —CR1R2R3, —NR4R5 and —OR6, wherein R1 to R5 are selected from H and essentially hydrocarbon moieties that optionally comprise at least one oxygen, nitrogen or silicon atom, and R6 is selected from essentially hydrocarbon moieties that optionally comprise at least one oxygen, nitrogen or silicon atom; and A is an essentially hydrocarbon moiety that optionally comprises at least one oxygen, sulphur, nitrogen or silicon atom, with the proviso that the compound A-CHO is a fragrant aldehyde. The use of these compounds in laundry, household and personal care products confers a long-lasting freshness.Type: ApplicationFiled: June 13, 2007Publication date: August 13, 2009Inventor: Felix Flachsmann
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Publication number: 20090182058Abstract: The present invention relates to novel chalcone derivatives of formula (I): wherein X, Y, Z, W, RI, R2, R3, R4 and R5 are as defined, said derivatives having antimitotic activity, as well as to pharmaceutical compositions containing such compounds and to their use for making drugs.Type: ApplicationFiled: January 15, 2007Publication date: July 16, 2009Inventors: Ahcene Boumendjel, Charles Dumontet, Madeleine Blanc, Anne-Marie Mariotte
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Publication number: 20090143374Abstract: Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A? amyloidosis, such as observed in Alzheimer's disease, use in the reduction of A? peptide in vivo, use in modulating APP processing, and use in modulating the activity of APP secretase.Type: ApplicationFiled: December 8, 2008Publication date: June 4, 2009Inventors: Alan D. Snow, Qubai Hu, Judy A. Cam
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Publication number: 20090143279Abstract: The present invention provides methods of treating of disorders characterized by defective mitochondrial activity. In particular compounds of the present invention can be used in the treatment metabolic diseases and neurodegenerative diseases. The methods are also useful to increase oxidative phosphorylation or to decrease reactive oxygen species (ROS) production in a subject in need thereof.Type: ApplicationFiled: June 13, 2008Publication date: June 4, 2009Inventors: Vamsi Krishna Mootha, Bridget Wagner, Toshimori Kitami
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Publication number: 20090131340Abstract: A method of treating or prophylactically treating immunosuppression or allergic and inflammatory symptoms of skin caused by UVB radiation which comprises applying to the skin a cosmetic or dermatological composition which comprises one or more flavonoids.Type: ApplicationFiled: January 16, 2009Publication date: May 21, 2009Applicant: Beiersdorf AGInventors: Ghita LANZENDORFER, Franz Stab, Sven Untiedt
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Publication number: 20090124703Abstract: A method for preparing a xanthohumol-rich hop composition. The method includes providing a solution that contains xanthohumol-containing hop substances and effecting precipitation of non-xanthohumol hop substances by adjusting both the salt concentration and pH value of the solution. The xanthohumol-rich hop composition prepared by this method can be used for treating various diseases, e.g., skin disorders, and bacterial infection.Type: ApplicationFiled: August 13, 2008Publication date: May 14, 2009Applicant: Flaxan LLC.Inventors: Mitsunori Ono, Naoto Yamaguchi
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Publication number: 20090110735Abstract: The present invention provides stable, self-assembling, biocompatible and biodegradable hydrogel formulations, into which one or more compounds may be incorporated allowing for delayed release or controlled release of the incorporated compounds as the hydrogel is degraded in the body.Type: ApplicationFiled: August 22, 2008Publication date: April 30, 2009Inventors: Edward T. Maggio, Elias Meezan, Dennis J. Pillion, Sarah L. Morgan, Joe Baggott
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Publication number: 20090081262Abstract: The invention relates to process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid water-insoluble particulate matter with a cationic additive in an aqueous medium to obtain a dispersion of said particulate matter having a positive zeta potential; (b) coating the solid water-insoluble particulate matter by precipitation of a metal oxide salt onto the surface of the particulate matter, forming a metal oxide layer thereon; and (c) aging said coating layer The invention further relates to coated particulate matter obtained by the process and to compositions comprising solid, water-insoluble particulate matter, coated by a metal oxide layer, the particulate matter being a dermatological active agent or a pesticide. The invention additionally relates to methods of treating a surface condition in a subject using compositions comprising solid, water insoluble dermatologically active agent, coated by a metal oxide layer.Type: ApplicationFiled: August 2, 2006Publication date: March 26, 2009Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer Toledano, Hanan Sertchook, Natalia Loboda, Hiam Bar-Simantov
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Publication number: 20090075957Abstract: The present invention provides compositions comprising an effective amount of xanthohumol and honokiol. The present invention comprises compositions comprising an effective amount of xanthohumol and genistein. The present invention comprises compositions comprising an effective amount of xanthohumol and guggulsterone. The compositions of the present invention may be effective to decrease mature adipocytes viability, induce apoptosis of mature adipocytes, increase lipolysis in mature adipocytes, and/or reduce adipogenesis during the maturation of pre-adipocytes. The present invention further provides methods of treating obesity, diabetes, osteoporosis or bone disorders in a subject, which comprise administering to the subject compositions comprising an effective amount of xanthohumol and honokiol, guggulsterone, or genistein.Type: ApplicationFiled: September 12, 2008Publication date: March 19, 2009Inventors: Clifton A. Baile, Mary Anne Della-Fera, Hea Jin Park, Jeong-Yeh Yang, Srujana Rayalam
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Publication number: 20090018167Abstract: The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiogenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.Type: ApplicationFiled: August 22, 2008Publication date: January 15, 2009Applicants: J. Phillip Bowen, Emory UniversityInventors: J. Phillip Bowen, Thomas Philip Robinson, Tedman Ehlers, David Goldsmith, Jack Arbiser
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Publication number: 20080234293Abstract: Cannabinoid derivatives according to formula (I) are disclosed wherein, X, Y, R1, R2, and W can have the definitions provided herein. Without limitation, use of such compounds, their salts or pro-drug, or compositions containing the compounds, salts, or pro-drug, to modify the activity of CB1 and CB2 receptors and treat conditions mediated by these receptors.Type: ApplicationFiled: March 3, 2008Publication date: September 25, 2008Inventors: Bob M. Moore, Himanshu Bhattacharjee, Charles R. Yates, Leslie Stuart
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Publication number: 20080227867Abstract: The use is described of the 4-hydroxychalcone derivatives of the formula (I) wherein A may represent a single or double bond, R1, R2 and R3, mutually independently, may in each case mean H, OH or (preferably C1-C4) alkoxy, providing that at least one of the residues R1 to R3 means OH, and R4 means H, OH or (preferably C1-C4) alkoxy, and/or (ii) the salts thereof and (iii) mixtures thereof to mask or reduce the unpleasant taste impression of an unpleasant tasting substance, as are corresponding methods and preparations.Type: ApplicationFiled: March 12, 2008Publication date: September 18, 2008Applicant: SYMRISE GmbH & Co. KGInventors: Jakob Ley, Susanne Paetz, Thomas Riess, Gerhard Krammer
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Publication number: 20080188549Abstract: The present invention has its object to provide a specific compound derived from a naturally occurring substance, and a composition for the prevention and/or treatment of metabolic syndrome and insulin resistance syndrome which comprises that as an active ingredient, easily and efficiently. The present invention relates to a composition for the prevention and/or treatment of metabolic syndrome and a composition for the prevention and/or treatment of insulin resistance syndrome, each of which comprises, as an active ingredient, at least one compound selected from among the compound represented by the formula (1), compounds represented by the formula (4) and compounds represented by the formula (5), or a salt or ester thereof.Type: ApplicationFiled: February 8, 2006Publication date: August 7, 2008Applicant: Kaneka CorporationInventors: Hozumi Tanaka, Shinichi Yokota, Misuzu Tsukagawa, Tatsumasa Mae, Minpei Kuroda, Yoshihiro Mimaki
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Patent number: 7402706Abstract: In this patent we describe the purification of prenylated benzophenones from the fruit rinds of Garcinia species and its evaluation as an inhibitor for Histone acetyltransferases p300 and PCAF. We have found that prenylated benzophenones are potent HAT inhibitors of p300 (IC50-1 ?M) and pCAF (IC50-15 ?M). The inhibitors significantly repress the p300 HAT dependent transcriptional activation from in vitro assembled chromatin template but had no effect on transcription from DNA. These results suggest that the compounds could be specific to HATs. Thus these compounds should be useful as biological switching molecule for evaluating the role of p300 and PCAF in cellular functions and may be useful as new chemical entities for the development of anticancer drugs.Type: GrantFiled: November 4, 2004Date of Patent: July 22, 2008Assignee: Jawaharlal Nehru Centre for Advanced Scientific ResearchInventors: Kundu Tapas Kumar, Karanam Balasubramanyam, Kempegowda Mantelingu, Altaf Mohammad, Venkatesh Swaminathan, A. Varier Radhika
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Publication number: 20080114073Abstract: Trisubstituted phenol compounds and methods of using the compounds, e.g., for anesthetizing a subject, are disclosed.Type: ApplicationFiled: July 13, 2007Publication date: May 15, 2008Inventor: Max T. Baker
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Patent number: 7326734Abstract: Compositions of matter and methods wherein chalcone and flavone derivatives are administered to human or veterinary patients for the treatment of bladder or urinary tract cancer. Compounds of the invention include 2?-hydroxy-4,4?,6?-trimethoxychalcone (Flavokawain A).Type: GrantFiled: April 1, 2004Date of Patent: February 5, 2008Assignee: The Regents of the University of CaliforniaInventors: Xiolin Zi, Anne R. Simoneau
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Publication number: 20080021095Abstract: The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of the anti-apoptotic effects of XIAP family member proteins. The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases).Type: ApplicationFiled: March 22, 2005Publication date: January 24, 2008Inventors: Jianyong Chen, Zaneta Nikolovska-Coleska, Dajun Yang, Shaomeng Wang, Haiying Sun, Liang Xu, Zengjian Hu
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Publication number: 20070299017Abstract: There is disclosed a composition comprising at least one of a compound selected from the group consisting of a bioflavonoid, a beta-1,3-beta-1,4-polymer of glucose having a weight average molecular weight (MW) of not greater than 1000 kDa, and a sterol. Moreover, there is disclosed a food or beverage or health supplement product comprising the disclosed composition. Further, there is disclosed a method of lowering blood serum cholesterol levels comprising administering to a patient in need thereof an effective amount of the disclosed composition.Type: ApplicationFiled: June 25, 2007Publication date: December 27, 2007Inventors: Mitchell M. Kanter, Melanie Jean Goulson, Bruce M. Resnick
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Patent number: 7256219Abstract: The present invention is directed to multifluoro-substituted Chalcones and analogs thereof, represented by the general Formula I: wherein Ar and R6-R10 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.Type: GrantFiled: March 14, 2002Date of Patent: August 14, 2007Assignee: Cytovia, Inc.Inventors: Sui Xiong Cai, P. Sanjeeva Reddy, John A. Drewe, Bao Ngoc Nguyen, Shailaja Kasibhatla
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Patent number: 7112698Abstract: The present invention pertains to compounds of the following formula: (1) wherein: RALK is primary or secondary aliphatic saturated C2-6alkyl; each of RB2, RB3, RB4, and RB5 is independently —H, —OH, or —OMe; each of R1 and R2 is independently: —H, optionally substituted C1-4alkyl, or optionally substituted C5-20aryl; RA3 is —H, —OH, —OC(?O)RE, —OS(?O)2OH, or —OP(?O)(OH)2; RE is: —H, optionally substituted C1-6alkyl, optionally substituted C3-20heterocyclyl, or optionally substituted C5-20aryl; or a pharmaceutically acceptable salt, solvate, amide, ester, ether, chemically protected form, or prodrug thereof.Type: GrantFiled: September 30, 2002Date of Patent: September 26, 2006Assignee: Spear Therapeutics LimitedInventors: Gerard Andrew Potter, Taeeba Ijaz