Plural Alicyclic Rings Patents (Class 514/691)
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Publication number: 20130209534Abstract: A substrate of polymeric material for wound care contains at least one oleous antimicrobial and/or helping tissue regeneration substance that is selected from Hyperforin, Adhyperforin, 1-3 Diapigenin, 11-8 Diapigenin, Rutin, Quercetin, Hypericin, Azadirachtin ?-?, Nimbin, Nimbidin, Salanin, Gallic Acid, Gedunin and combinations thereof.Type: ApplicationFiled: June 4, 2012Publication date: August 15, 2013Applicant: MOSES S.R.L.Inventors: Chiara GUALANDI, Maria Letizia FOCARETE, Andrea ZUCCHELLI, Maria Letizia IABICHELLA
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Publication number: 20130203718Abstract: The present invention relates to a compound of formula (I): for its use as progesterone receptor antagonist, in particular for its use for the prevention and/or the treatment of cancer or uterine pathologies.Type: ApplicationFiled: May 9, 2011Publication date: August 8, 2013Inventors: Marie-Edith Rafestin-Oblin, Mouad Alami, Hugues Loosfelt, Abdallah Hamze, Ali Junaid Khan, Abdellatif Tikad, Marc Lombes, Jean-Daniel Brion
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Publication number: 20130197097Abstract: The present invention provides novel spiroenones extracted from an alcohol extract of dehulled adlay seeds. The present invention also provides a process for the preparation of the spiroenones and a method for treating breast cancer in a subject, which method comprises administering to said subject an effective amount of the spiroenone and a pharmaceutically acceptable carrier or excipient.Type: ApplicationFiled: February 1, 2012Publication date: August 1, 2013Inventors: WENCHANG CHIANG, YUEH-HSIUNG KUO, YUN-LIAN LIN, CHENG-PEI CHUNG
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Publication number: 20130165453Abstract: The invention provides for the use of protein kinase activators or boosters of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) or other neurotrophic factors to treat stroke. Specifically, the present invention provides methods of treating stroke comprising the steps of identifying a subject having suffered a stroke and administering to said subject an amount of a pharmaceutical composition comprising a protein kinase C (PKC) activator or 4-methylcatechol acetic acid (MCBA) and a pharmaceutically acceptable carrier effective to treat at least one symptom of stroke.Type: ApplicationFiled: July 19, 2012Publication date: June 27, 2013Inventors: Miao-Kun Sun, Daniel L. Alkon
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Publication number: 20130137662Abstract: The present invention relates to the use canthaxanthin and/or 25-hydroxy vitamin D3 (25-OH D3) for improving reproductive performance of roosters. More particularly, the invention relates to the use of Canthaxanthin and/or 25-hydroxy canthaxanthin in the manufacture of a food or veterinary composition for improving reproductive performance of roosters.Type: ApplicationFiled: December 7, 2010Publication date: May 30, 2013Inventor: Jose Maria Hernandez
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Publication number: 20130131184Abstract: Disclosed are an aqueous cosmetic preparation including at least astaxanthin, 20 ?g/L or more of iron ions, and an iron chelating agent, and a method for suppressing the decomposition of astaxanthin in which an iron chelating agent is included in an aqueous composition including at least astaxanthin and 20 ?g/L or more of iron ions.Type: ApplicationFiled: January 24, 2013Publication date: May 23, 2013Applicant: FUJIFILM CORPORATIONInventor: Fujifilm Corporation
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Publication number: 20130096175Abstract: Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation.Type: ApplicationFiled: November 17, 2010Publication date: April 18, 2013Applicants: SOUTHERN RESEARCH INSTITUTE, UNIVERSITY OF ROCHESTERInventors: David S. Goldfarb, Joseph A. Maddry, Lynn Rasmussen, Ellie Lucile White, Krister Wennerberg
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Publication number: 20130095142Abstract: Provided is a lipid emulsion having krill oil as an active ingredient and a preparation method therefor, wherein the lipid emulsion can be used independently for oral/parenteral administration or as a daily nutrient, and preferably, as a nutritious intravenous lipid emulsion having krill oil.Type: ApplicationFiled: March 25, 2011Publication date: April 18, 2013Applicant: SNU R&DB FoundationInventor: Wan Gyoon Shin
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Publication number: 20130072553Abstract: This invention relates to the drugs, derivatives and analogs containing adamantane structures of new indication applications of anti-tumor. The invention also relates to above compounds to treat tumors and other diseases with FIG. 1. These drugs, derivatives and analogs are generated by the modification of the parent or fragment structures and formation of pharmaceutically acceptable salts, complex salts or prodrug. The drugs, derivatives and analogs as described are administered alone or together with at least one known anti-tumor and immune chemotherapeutic agent including treatment of viral, bacterial and fungal diseases, neurological diseases, endocrine system diseases, and immune system diseases.Type: ApplicationFiled: December 25, 2009Publication date: March 21, 2013Inventor: Lifeng Xu
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Patent number: 8399522Abstract: The present invention pertains to a method of counteracting a malodor by introducing a malodor counteracting effective amount of a novel 3.2.Type: GrantFiled: October 8, 2010Date of Patent: March 19, 2013Assignee: International Flavors & Fragrances IncInventors: Benjamin Amorelli, Johan Gerwin Lodewijk Pluyter, Adam P. Closson
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Patent number: 8383682Abstract: A composition comprises surface-modified nanoparticles of at least one amphoteric metal oxide or oxyhydroxide. The nanoparticles bear, on at least a portion of their surfaces, a surface modification comprising (i) at least one surface modifier selected from lactate, thiolactate, and mixtures thereof, and (ii) at least one surface modifier selected from halide, nitrate, acetate, carbonate, formate, propionate, sulfate, bromate, perchlorate, tribromoacetate, trichloroacetate, trifluoroacetate, carboxylate comprising from one to about four alkyleneoxy moieties, chlorate, and mixtures thereof.Type: GrantFiled: December 16, 2008Date of Patent: February 26, 2013Assignee: 3M Innovative Properties CompanyInventor: Timothy D. Dunbar
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Publication number: 20130045177Abstract: An excellent potential-dependent cation channel inhibitor or an excellent masking agent is provided.Type: ApplicationFiled: April 26, 2011Publication date: February 21, 2013Inventors: Hiroko Takatoku, Kentaro Kumihashi, Daisuke Yamazaki
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Patent number: 8367090Abstract: A coating on a balloon of a medical device is provided. The coating comprises a drug and a polymer. Also provided are methods of forming and using the coating.Type: GrantFiled: September 5, 2008Date of Patent: February 5, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Stephen D. Pacetti, John Stankus
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Publication number: 20130012594Abstract: An object of the present invention is to provide a method for microbiologically producing astaxanthin of high concentration at low cost while suppressing production of canthaxanthin. Specifically, the present invention relates to a method for producing carotenoids including astaxanthin comprising culturing a bacterium that concurrently produces astaxanthin and canthaxanthin in a medium containing biotin, wherein a ratio of concentration of produced canthaxanthin to concentration of produced astaxanthin in a culture product after the end of culture in the medium is lower than that in a culture product after the end of culture in a biotin-free medium.Type: ApplicationFiled: March 15, 2011Publication date: January 10, 2013Applicant: JX Nippon Oil & Energy CorporationInventors: Kazuaki Hirasawa, Hiroshi Satoh, Hisashi Yoneda, Tetsuhisa Yata, Matsutoshi Azuma
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Publication number: 20130005828Abstract: Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found with krill oil and/or marine oil in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.Type: ApplicationFiled: September 11, 2012Publication date: January 3, 2013Applicant: U.S. NUTRACEUTICALS, LLC d/b/a Valensa InternationalInventors: John A. Minatelli, W. Stephen Hill, Swati Sebastian Thomas, Lingan Rajendran, Rudi E. Moerck
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Publication number: 20120329880Abstract: The present invention relates to a method of preparing for an oil suspension of carotenoid with low viscosity and high fluidity and use thereof. The method comprises the following steps: mixing carotenoid crystals with tetrahydrofuran, heating the mixture to reflux temperature 50˜70°C. under stirring to dissolve the crystal, filtering and condensing to obtain the concentrate; mixing the concentrate with ketone solvent, heating the mixture to reflux temperature 60-80? to dissolve the concentrate, filtering, condensing, adding absolute alcohol, crystallizing under stirring at room temperature, filtering and drying in vacuum to obtain carotenoid crystals; mixing carotenoids crystals after granded with plant oil or grinding carotenoid crystals with plant oils and then adding plant oil, to obtain the oil suspension of carotenoid with low viscosity and high fluidity. While the content of carotenoid is 10.0˜45.0 wt.Type: ApplicationFiled: March 4, 2010Publication date: December 27, 2012Inventors: Xinde Xu, Guohua Wei, Xuebing Xiang, Bin Shao
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Publication number: 20120316144Abstract: An antifungal agent including a mastic normal-hexane extract containing at least one of triterpenes expressed by the following chemical formulas 1 to 6; and squalene.Type: ApplicationFiled: April 30, 2010Publication date: December 13, 2012Inventor: Hideo Minobe
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Publication number: 20120315345Abstract: One or more embodiments of the present invention describe a novel use of capsanthin and/or fatty-acyl ester of capsanthin to inhibit both the differentiation of pre-adipocytes to adipocytes and the accumulation of fat in the adipocytes. One or more embodiments of the present invention are based on findings that capsanthin contained in some natural products such as red pepper, paprika, bell pepper, etc. have anti-adipogenic activity by inhibiting both the differentiation of pre-adipocyte into adipocyte and the accumulation of fat in adipocytes, Therefore, this findings provide a functional food and a pharmaceutical composition wherein capsanthins and the extract of any natural products containing the same components are included in the functional food and the pharmaceutical composition, to offer obesity prevention and/or treatment effects.Type: ApplicationFiled: May 29, 2012Publication date: December 13, 2012Applicant: ESBIOTECH CO., LTD.Inventors: Byung-Hoon HAN, Jeong-Won KIM, Sung-Jun JO, Hye-Ok CHOI, Jung-Hwan KIM, Moo-Kang KIM, Il-Kwon PARK, Seung-Hwan LEE
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Publication number: 20120308620Abstract: A dermatological topical formulation such as a cream, ointment, or lotion containing an elastogenesis inducer and a systemic absorption retardant is described. Such a formulation achieves high local tissue concentration of the elastogenesis inducer in the vicinity of the application site, minimizes systemic absorption of the elastogenesis inducer, and maximizes a concentration of the elastogenesis inducer in dermis, resulting in formation or restoration of elastin fibers in adult skin. The formulation can further contain a skin penetration enhancer compound.Type: ApplicationFiled: June 7, 2012Publication date: December 6, 2012Applicant: AtheroNova Operations, Inc.Inventors: Filiberto P. Zadini, Giorgio C. Zadini
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Publication number: 20120308512Abstract: The present invention comprises a bio-polymer based solid for the sustained release of an active agent into the air consisting of: a) a primary starched—based polymer; b) a secondary polyether block amide polymer, and: c) a filler component. d) one or more active oils The active oils can be one or more fragrances so as to provide an air freshening composition, a flavor to create a certain aromatic environment or a repellant such as insect repellants for the elimination of mosquitoes and the like. Animal repellants may be incorporated to ward off unwanted pets and wildlife outside the home and attractants may also be utilized in the production of fishing lures and the like.Type: ApplicationFiled: August 17, 2011Publication date: December 6, 2012Applicant: Aromatic Fusions Inc.Inventors: Paul Albee, Eric Matthew Albee, Sandra Albee Keeley
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Patent number: 8313744Abstract: The present invention relates to a composition comprising PKC agonist as an active ingredient. More precisely, the present inventors confirmed that absence seizure specific SWD was reduced by administrating PKC agonist into an animal model. Therefore, the composition of the present invention comprising PKC agonist as an active ingredient can be effectively used for the prevention and treatment of absence seizure and for the production of health improving functional food.Type: GrantFiled: August 5, 2010Date of Patent: November 20, 2012Assignee: Korea Institute of Science and TechnologyInventors: Eunji Cheong, Hee-Sup Shin, Yihong Zheng, Kyoobin Lee, Jungryun Lee, Seongwook Kim, Maryam Sanati, Sukyung Lee, Yeon-Soo Kim, Sukchan Lee
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Publication number: 20120264820Abstract: A compound, pharmaceutical composition and method for the treatment of mammals wherein the active therapeutic agent is a compound having the structure: wherein: R1 is an electronegative substituent, R2 is R1 or alkyl, R3 is H or O-alkyl, R4 and R5 are the same or different and are alkyl and R6 is H or OH.Type: ApplicationFiled: December 31, 2007Publication date: October 18, 2012Inventors: Kinfe Redda, Chavonda Janeebra Mills, Nelly Maleeva
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Publication number: 20120238522Abstract: The present invention is directed to carotenoid compositions and methods for inhibiting the growth of pathogenic bacteria or for preventing or treating bacterial infections in subjects by administration of an effective amount of astaxanthin and beta-carotene.Type: ApplicationFiled: June 1, 2012Publication date: September 20, 2012Inventors: Zeina Jouni, Zeina Makhoul
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Publication number: 20120213872Abstract: There are provided various compounds and compositions comprising polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds and compositions can be useful as cancer chemopreventive agents. They can also be useful for enhancing solubility of various active agents and enhancing their bioavailability.Type: ApplicationFiled: April 30, 2012Publication date: August 23, 2012Inventor: Samuel FORTIN
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Publication number: 20120202889Abstract: The present invention relates to a method for reducing the relative ratio of 3-hydroxy-3?,4?-didehydro- ?, ?-caroten-4-one (HDCO) to astaxanthin in a composition containing astaxanthin and HDCO by contacting the composition with an acidic medium having a pH of 3 or less and/or a basic medium having a pH of 9 or greater, and also relates to a method for producing an astaxanthin-containing composition which includes reducing the relative ratio of HDCO by the above method. By means of the method of the present invention, the relative ratio of HDCO, the biological function of which is not known, in an astaxanthin-containing composition can be easily reduced.Type: ApplicationFiled: August 11, 2010Publication date: August 9, 2012Applicant: KANEKA CORPORATIONInventors: Hiroaki Inoue, Noriyuki Kizaki, Hirokazu Nanba
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Publication number: 20120184612Abstract: A pet food composition having at least two carotenoids. The carotenoids can include a keto-carotenoid and at least one non-keto-carotenoid. The keto-carotenoid can include astaxanthin. The keto-carotenoid can include astaxanthin ester. The non-keto-carotenoid can include beta-carotene and/or lutein.Type: ApplicationFiled: January 11, 2012Publication date: July 19, 2012Inventor: Jin Zhang
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Patent number: 8193249Abstract: The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune or anti-inflammatory compounds.Type: GrantFiled: May 29, 2009Date of Patent: June 5, 2012Assignee: Emory UniversityInventors: Susheng Wang, Dennis C. Liotta, James P. Snyder, Hariharan Venkatesan
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Publication number: 20120129924Abstract: The present invention relates to a pharmaceutical composition for preventing or treating hyperlipidemia, fatty liver, diabetes and obesity comprising a sesquiterpene derivative as an active ingredient. The sesquiterpene derivatives of the present invention leads to decrease in body fat weight, visceral fat weight and total cholesterol levels, triglyceride of plasma and liver tissue, blood glucose and blood insulin levels in a fast state, finally exhibiting efficacies on prevention or treatment of hyperlipidemia, fatty liver, diabetes and obesity.Type: ApplicationFiled: October 20, 2008Publication date: May 24, 2012Applicant: KWANG DONG PHARM. CO., LTD.Inventors: Tae-Sun Park, Ha-Won Kim
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Publication number: 20120122870Abstract: Ischemia-reperfusion injury remains a primary cause of morbidity and mortality in individuals who experience disruption of normal blood flow to one or more major organs. For example, there are no clinically proven strategies that prevent acute renal failure following cardiac surgery. The present invention provides a variety of methods for the treatment or prevention of ischemia-reperfusion injury. In one aspect of the invention, a method for treating or preventing ischemia-reperfusion injury includes administering to a subject an effective amount of a sphingosine kinase inhibitor. Sphingosine kinase inhibitors are very effective in the protection against IR-induced acute renal failure and liver failure. Moreover, the effects occur very early after administration, requiring only a very short time of treatment. Toxicology studies with sphingosine kinase inhibitors demonstrate that they have low toxicity, even in long-term treatment.Type: ApplicationFiled: May 10, 2010Publication date: May 17, 2012Applicants: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT, APOGEE BIOTECHNOLOGY CORPORATIONInventors: Charles D. Smith, Zhi Zhong, Lynn W. Maines
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Publication number: 20120107428Abstract: Provided herein are essential oils and synthetic compounds, and combinations thereof, as repellent compositions for repelling insects, such as vespid social wasps (Vespidae), including yellowjackets, paper wasps, and hornets. Controlled release devices comprising these repellent compositions are also provided.Type: ApplicationFiled: August 9, 2011Publication date: May 3, 2012Applicant: Sterling International Inc.Inventors: Rodney G. Schneidmiller, Qing-He Zhang, Doreen R. Hoover
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Publication number: 20120107380Abstract: This invention relates to a practical and effective process for converting esterified xanthophylls, including zeaxanthin, to non-esterified xanthophylls through saponification. In addition, the invention provides a process for obtaining esterified zeaxanthin in high yields and purities, isolating the xanthophylls from interfering substances such as waxes, oils, and fats. A product of this process is a zeaxanthin rich substrate that is suitable for use in foods, nutritional supplements, cosmetics, pharmaceuticals and related products.Type: ApplicationFiled: May 28, 2010Publication date: May 3, 2012Applicant: Kalamazoo Holdings, Inc.Inventors: Joshua James Tuinstra, Gregory S. Reynhout, James Barren
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Publication number: 20120095004Abstract: The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.Type: ApplicationFiled: October 19, 2011Publication date: April 19, 2012Applicant: APOGEE BIOTECHNOLOGY CORPORATIONInventors: Charles D. Smith, Kevin J. French, Yan Zhuang
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Publication number: 20120058965Abstract: Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual.Type: ApplicationFiled: June 17, 2011Publication date: March 8, 2012Inventors: William A. GODDARD, III, Mark MENNA, Stephen PANDOL, Ravinder ABROL
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Publication number: 20120058977Abstract: A pharmaceutical composition for the treatment of a disease caused by a bacterium that belongs to the group of nocardioform actinomycetes, said composition comprising an effective amount of a compound selected from compound I, (+)-compound II, (?)-compound II, compound III, or mixtures thereof.Type: ApplicationFiled: February 23, 2010Publication date: March 8, 2012Applicant: Rijksuniversiteit GroningenInventors: Robert Van Der Geize, Lubbert Dijkhuizen, Martin Ostendorf, Peter Van Der Meijden
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Publication number: 20120052019Abstract: Chemical entities which are triterpenoid derivatives, pharmaceutical compositions and methods of treatment of inflammatory, neurodegenerative, neoplastic and autoimmune diseases are described.Type: ApplicationFiled: August 22, 2011Publication date: March 1, 2012Inventors: Xiangping Qian, Yong-Liang Zhu
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Patent number: 8124656Abstract: This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.Type: GrantFiled: February 23, 2011Date of Patent: February 28, 2012Assignee: Reata Pharmaceuticals, Inc.Inventors: Eric Anderson, Xin Jiang, Xiaofeng Liu, Melean Visnick
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Publication number: 20120046359Abstract: Control or repellency of bed bugs by bringing the bed bugs into contact with a bed bug control formulation containing at least one compound selected from the group consisting of certain alkyl ketones and cyclic ketones wherein the total number of carbon atoms in the alkyl ketones and cyclic ketones is from 10 to 16 carbon atoms and method for achieving such control or repellency.Type: ApplicationFiled: October 27, 2011Publication date: February 23, 2012Inventor: Robert H. Bedoukian
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Publication number: 20120041064Abstract: The present invention relates generally to the cosmetic treatment of aged skin. More specifically, the invention relates to the use of ingenol compounds, particularly ingenol angelates, in treating photo-aged and/or chronologically-aged skin.Type: ApplicationFiled: February 12, 2010Publication date: February 16, 2012Applicant: PEPLIN RESEARCH PTY LTDInventors: Steven Martin Ogbourne, David Thomas, Ryan Moseley, James Harrison Aylward
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Publication number: 20120039964Abstract: The present invention relates to formulations of a pharmacological effective fat-soluble active ingredient with a high bioavailability of said fat-soluble active ingredient as well as to their manufacture and use as dietary supplement, food, feed, personal care product and/or pharmaceutical. Such formulations are those which when dissolved, dispersed or diluted in/with water have an extinction E1/1 at a wavelength in the range of from 200 to 800 nm, preferably in the range of from 250 to 600 nm, more preferably in the range of from 250 to 500 nm, more preferably in the range of from 370 to 485 nm, of ?380, preferably of ?600, most preferably ?900. In preferred embodiments of the formulations of the present invention such formulations show an extrusion loss of fat-soluble active ingredient of ?30% when pressed to tablets.Type: ApplicationFiled: October 27, 2011Publication date: February 16, 2012Inventors: Markus BECK, Hansjoerg Grass, Bruno H. Leuenberger, Markus Nowotny, Christian Schäfer, Karl Manfred Voelker
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Publication number: 20120029088Abstract: This invention provides a highly safe anti-anxiety composition that can be used for treatment or prevention of anxiety disorders. Such anti-anxiety composition comprises, as an active ingredient, a carotenoid.Type: ApplicationFiled: July 21, 2011Publication date: February 2, 2012Applicant: JX NIPPON OIL & ENERGY CORPORATIONInventors: Hideaki HARA, Atsushi OOYAGI, Takashi ISHIBASHI
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Publication number: 20120028957Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.Type: ApplicationFiled: August 1, 2010Publication date: February 2, 2012Inventors: William F. DeGrado, Jun Wang
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Publication number: 20120010281Abstract: Infections caused by Mycobacterium tuberculosis kill more than 1.8 million people each year. While the persistence of this pathogenic bacterial species and the emergence of multidrug resistant strains have created an urgent need for new TB therapies, a new TB-specific drug has not been developed in over 40 years. The disclosure herein provides short and scalable syntheses of small molecules, and small molecules as new therapeutics for eradicating this life threatening pathogen.Type: ApplicationFiled: June 22, 2011Publication date: January 12, 2012Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Erik J. Sorensen, Stephen D. Lotesta, Junjia Liu, Emma V. Yates, Maurice A. Marsini
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Publication number: 20120010177Abstract: The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.Type: ApplicationFiled: August 1, 2011Publication date: January 12, 2012Applicant: The Wistar Institute / North Carolina State UniversityInventors: Qihong Huang, Alexander Deiters, Kiranmai Gumireddy
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Publication number: 20120004319Abstract: The present invention provides a method for producing a carotenoid-containing composition, comprising the steps of: subjecting a culture of a carotenoid-producing microorganism to an extraction treatment using a water-soluble organic solvent; dispersing the resulting extract solution in water for micellization; heat stirring the resulting micellized solution in a solvent break the micelles and precipitate the carotenoid component of interest to obtain the precipitate; collecting and heat washing the precipitate with ethanol; and further subjecting the precipitate to pulverization/drying; and food, a pharmaceutical composition and a cosmetic product comprising the carotenoid-containing composition.Type: ApplicationFiled: March 1, 2010Publication date: January 5, 2012Inventors: Kentaro Shimizu, Tomoyuki Ishizaki, Toshiyuki Takahashi, Shotaro Uchizawa
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Publication number: 20120004297Abstract: An agent for alleviating, treating and preventing vascular failure and a vascular endothelial cell-protecting agent characterized by containing, as an effective ingredient, at least one active oxygen scavenger such as astaxanthin and tocotrienols; and a food, a drink and an animal feed having an effect of alleviating, treating and preventing vascular failure and an effect of protecting vascular endothelial cells characterized by containing, as the effective ingredient, at least one active oxygen scavenger such as astaxanthin and tocotrienols.Type: ApplicationFiled: August 18, 2011Publication date: January 5, 2012Inventors: Naoki Higashi, Jiro Takahashi
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Patent number: 8044103Abstract: The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activity, the compounds can be used to enhance memory and to treat a variety of neurological disorders. The compounds are particularly useful for treating neurological disorders caused by, or associated with, CNS trauma.Type: GrantFiled: February 22, 2007Date of Patent: October 25, 2011Assignee: Georgetown UniversityInventors: Alan P. Kozikowski, Alan I. Faden, Gian Luca Araldi
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Publication number: 20110250259Abstract: Breast cancer is a common cancer in women. Early diagnosis and treatments are vital for better outcomes. This formula consists of a liquid anti-disease anti-cancer formula that can be delivered to the source where breast cancer begins. Method of treating breast disease, including cancer, with a formula and a means of delivery with a topical, intraductal, ductal, and/or intraductal infusion to prevent the formation of cancer or precursors to cancer or atypia or other form of abnormal breast tissue or to treat breast diseases of all kinds. May include homeopathic remedies to be used topically or inside the breast with a delivery method to those regions and may be processed with or without photonic programming or an ionic delivery system for greater effectiveness and use against degenerative diseases or cancerous or precancerous diseases, precursors of breast disease, inflammatory breast disease, or accumulation of toxins in the breast tissue.Type: ApplicationFiled: April 12, 2010Publication date: October 13, 2011Inventor: Kevin Buckman
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Patent number: 8034373Abstract: Methods for the reduction or prevention of oxidative stress in an animal comprising administering to the animal an effective amount of a composition comprising astaxanthin and/or Vitamin E are described. Also described are compositions comprising astaxanthin and/or Vitamin E, the compositions being effective for the reduction or prevention of oxidative stress in an animal.Type: GrantFiled: April 15, 2005Date of Patent: October 11, 2011Assignee: Nestec S. A.Inventors: Arleigh J. Reynolds, Janet R. Jackson, Mark K. Waldron
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Patent number: 8022255Abstract: A process for preparing ketones of the general formula (III) where R is an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted alkyl radical or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms, and R1 is an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms, by reacting alpha-oxo carboxylates of the general formula (I) wherein n and m is a number in the range from 1 to 6, M(m+) is a cation, and R has the meaning indicated for formula (III), with aryl bromides of the general formula (II) R1—Br??(II) where R1 has the meaning indicated for formula (III), in the presence of two transition metals or compounds thereof as catalyst, is described.Type: GrantFiled: February 19, 2009Date of Patent: September 20, 2011Assignee: SALTIGO GmbHInventors: Alain Cotte, Matthias Gotta, Lukas Goossen, Felix Rudolphi, Christoph Oppel, Nuria Rodriguez Garrido
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Publication number: 20110224306Abstract: The present invention relates to the use canthaxanthin and/or 25-hydroxy vitamin D3 (25-OH D3) for improving breeder hatchability and fertility and for lowering embryo mortality in poultry. More particularly, the invention relates to the use of Canthaxanthin and/or 25-hydroxy canthaxanthin in the manufacture of a food or veterinary composition for improving hatchability in poultry.Type: ApplicationFiled: November 11, 2009Publication date: September 15, 2011Applicant: DSM IP ASSETS B.V.Inventors: Jose-Maria Hernandez, Gilbert Weber